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Cipralex®/Lexapro (escitalopram)

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• Anafranil (clomipramine) / Auroix (moclobemide) / Buspar (buspirone) / Celexa (citalopram) / Cymbalta (duloxetine) / ECT / Edronax (reboxetine) / Effexor (venlafaxine) / gepirone / Lexapro (escitalopram) / Luvox (fluvoxamine) / Paxil (paroxetine) / Pristiq (desvenlafaxine) / Prozac (fluoxetine) / Remeron (mirtazapine) / RU-486 (mifepristone) / Serzone (nefazodone) / tianeptine / tricyclics / Wellbutrin (bupropion) / Zoloft (sertraline)

• St. John's wort / 5-HTP / SAMe / NADH / Omega-3 / tyrosine / acetyl-l-carnitine / DHEA / phenylalanine / ginkgo / phosphatidylserine / folate / antidepressants

Where to purchase:

• SuperSaverMeds.com
• Escitalopram 5mg (Generic Equivalent of Lexapro 5mg) - OffshoreRx1.com
• Escitalopram 10mg (Generic Equivalent of Lexapro 10mg) - OffshoreRx1.com
• Escitalopram 20mg (Generic Equivalent of Lexapro 20mg) - OffshoreRx1.com
• OffshoreRx1.com- Free shipping on orders over $250.
• Escitalopram at drugstore.com

News & Research:

• Lexapro (escitalopram oxalate) - rxlist.com
• Outmuscling major depression with creatine - Science Daily, 8/7/12 - "women with major depressive disorder (MDD) who augmented their daily antidepressant with 5 grams of creatine responded twice as fast and experienced remission of the illness at twice the rate of women who took the antidepressant alone ... Creatine is an amino acid made in the human liver, kidneys, and pancreas. It also is found in meat and fish. Inside the body it is converted into phosphocreatine and stored in muscle. During high-intensity exercise, phosphocreatine is converted into ATP, an important energy source for cells. For this reason, creatine has become a popular supplement among bodybuilders and athletes who are trying to add muscle mass or improve athletic ability ... The group that received creatine showed significantly higher improvement rates on the HDRS at two and four weeks (32 percent and 68 percent) compared to the placebo group (3.7 percent and 29 percent). At the end of eight weeks, half of those in the creatine group showed no signs of depression compared with one-quarter in the placebo group. There were no significant adverse side effects associated with creatine" - See creatine at Amazon.com.
• A Randomized, Double-Blind Placebo-Controlled Trial of Oral Creatine Monohydrate Augmentation for Enhanced Response to a Selective Serotonin Reuptake Inhibitor in Women With Major Depressive Disorder - Am J Psychiatry. 2012 Aug 1 - "Fifty-two women with major depressive disorder were enrolled in an 8-week double-blind placebo-controlled clinical trial and randomly assigned to receive escitalopram in addition to either creatine (5 g/day, N=25) or placebo (N=27) ... In comparison to the placebo augmentation group, patients receiving creatine augmentation showed significantly greater improvements in HAM-D score, as early as week 2 of treatment. This differential improvement favoring creatine was maintained at weeks 4 and 8" - See creatine at Amazon.com.
• Use of antidepressant associated with reduction in menopausal hot flashes - Science Daily, 1/18/11 - "In the escitalopram group, average hot flash frequency at week 8 decreased to 5.26 hot flashes per day (47 percent decrease or an average of 4.6 fewer hot flashes per day than at the beginning of the study). In the placebo group, hot flash frequency decreased to 6.43 hot flashes per day (33 percent decrease or an average of 3.2 fewer hot flashes per day)" - Note:  A significant placebo effect.  Some argue on trials like this that that the people receiving the real deal know because of the side effects of the medication therefore they have a greater placebo effect.
• Analysis Shows Sertraline, Escitalopram More Effective Than 10 Other New-Generation Antidepressants - Doctor's Guide, 1/29/09 - "Sertraline and escitalopram were found to be the best antidepressants overall in terms of efficacy and acceptability. Sertraline was more efficacious than duloxetine (by 30%); than both duloxetine and fluvoxamine (by 27% for both); 25% fluoxetine (by 25%); paroxetine (by 22%); and reboxetine (by 85%) ... Escitalopram was more efficacious than duloxetine (by 33%); fluoxetine (by 32%); fluvoxamine (by 35%); paroxetine (by 30%); and reboxetine (by 95%). As with sertraline and escitalopram, mirtazapine and venlafaxine were also more efficacious than these other drugs ... However, escitalopram and sertraline showed the best profile of acceptability, leading to significantly fewer discontinuations of treatment than did duloxetine, fluvoxamine, paroxetine, reboxetine, and venlafaxine"
• Superior Effectiveness and Tolerability of Escitalopram Over Paroxetine in Long-Term Treatment of Major Depressive Disorder - Doctor's Guide, 9/2/08 - "escitalopram resulted in a significantly greater reduction in the MADRS score from baseline compared with paroxetine, with a mean difference of 2.0 points ... Escitalopram-treated patients showed a greater overall response rate at the end of the study compared with paroxetine-treated participants (83.0% vs 76.8%)"
• Bupropion XL vs. Escitalopram in Generalized Anxiety Disorder - Medscape, 3/11/08 - "Response rates were significantly greater for bupropion XL (100%) than for escitalopram (62%)" - That surprised me because all the studies I've read had escitalopram beating just about everything for depression.
• Recent Trials in Generalised Anxiety Disorder Highlight Escitalopram, Duloxetine, and Anticonvulsants - Doctor's Guide, 11/21/07
• Data Presented Indicates Escitalopram may be a Promising Future Treatment Option in Obsessive Compulsive Disorder - Doctor's Guide, 9/19/06
• Escitalopram Helps Prevents Relapses of Obsessive-Compulsive Disorder - Doctor's Guide, 9/18/06
• Escitalopram Helps Prevent Relapse of Obsessive-Compulsive Disorder Symptoms - Doctor's Guide, 5/25/06
• Double-blind Data Show No Effect With Escitalopram in Compulsive Shopping Disorder - Doctor's Guide, 5/23/06
• Sexual Functioning in Long-term Treatment of MDD: Duloxetine, Escitalopram, and Placebo - Doctor's Guide, 5/23/06 - "the study found a statistically significant worsening of sexual functioning as measured by the Changes in Sexual Functioning Questionnaire (CSFQ) for escitalopram versus placebo at 4 weeks (P </=.01) while duloxetine was not statistically different from placebo"
• FDA OKs Generic Depression Drug - WebMD, 5/23/06
• Review Shows Escitalopram Prevents Relapse of Anxiety, Depression - Doctor's Guide, 3/27/06
• Bupropion and Escitalopram Provide Similar Relief in Depressed Patients - Medscape, 10/28/05
• For Major Depression, Escitalopram (Lexapro) Achieves Better Risk/Benefit Profile Than Venlafaxine XR (Effexor XR) - Doctor's Guide, 5/31/05
• Escitalopram Shows Efficacy in Depressed Patients With Comorbid Anxiety - Doctor's Guide, 5/27/05
• Escitalopram Effective in Comorbid Social Anxiety Disorder and Major Depression - Doctor's Guide, 3/23/05
• Escitalopram in Adolescent Major Depression - Medscape, 1/31/05
• Cipralex (Escitalopram) Appears to be at Least as Effective, Faster Acting and Better Tolerated Than is Venlafaxine in Treating Major Depressive Disorder - Doctor's Guide, 10/11/04
• Cipralex (Escitalopram) Appears to be Superior to Both Placebo and Paroxetine in Treatment of General Anxiety Disorder - Doctor's Guide, 10/11/04
• Escitalopram Effective for Long-Term Treatment of GAD - Clinical Psychiatry News, 9/04
• Continuation Treatment with Escitalopram Effective in Preventing Relapse Into An Episode Of Major Depressive Disorder - Doctor's Guide, 2/25/04
• FDA Approves Treatment for GAD - Physician's Weekly, 1/26/04
• Lexapro (Escitalopram Oxalate) Receives FDA Approval FOR Treatment OF Generalized Anxiety Disorder - Doctor's Guide, 12/18/03
• Lexapro (Escitalopram Oxalate) Starting Dose Appears As Effective As Optimally Dosed Zoloft (Sertraline) In Treatment Of Major Depressive Disorder - Doctor's Guide, 12/15/03
• Faster Onset, Higher Response Rate With Escitalopram Than Racaemic Counterpart - Doctor's Guide, 10/13/03
• FDA Grants Approvable Letter for Lexapro (Escitalopram Oxalate), Treatment of Generalized Anxiety Disorder - Doctor's Guide, 9/29/03
• Try Mirtazapine or Escitalopram for Speedy Onset - Clinical Psychiatry News, 8/03 - "When you need the quickest possible antidepressant effect, consider choosing mirtazapine or escitalopram for treatment or combining a selective serotonin reuptake inhibitor with pindolol or olanzapine"
• Significant Quality Of Life Improvements Seen In Patients With Generalised Anxiety Disorder Treated With Escitalopram - Doctor's Guide, 4/1/03
• Consider Escitalopram First For Severe Major Depression - Clinical Psychiatry News, 4/03
• Escitalopram Tx Leads to Remission in GAD - Clinical Psychiatry News, 4/03
• Escitalopram Effective, Well Tolerated Depression Tx in Primary Care Setting - Clinical Psychiatry News, 4/03
• Escitalopram Effective in Social Anxiety Disorder for Up to 36 Weeks - Doctor's Guide, 3/31/03
• Escitalopram Beneficial for Treating Various Anxiety Disorders - Doctor's Guide, 3/31/03
• Lexapro (Escitalopram Oxalate) Oral Solution Formulation Provides New Option for Depressed Patients - Doctor's Guide, 12/02/02
• Escitalopram Works for Anxiety Disorders, Panic - Clinical Psychiatry News, 11/02
• Escitalopram Shows "Strong and Early Efficacy" for Major Depression in Acute Phase - Doctor's Guide, 10/10/02
• Lexapro Bests Effexor in Depression Study - WebMD, 10/9/02
• Escitalopram Remission Reaches 86 Percent at One Year For Responders With Moderate or Severe Depression - Doctor's Guide, 10/9/02
• Escitalopram Achieves Earlier Response and Better Tolerability than Venlafaxine XR in First Head-to-Head Study - Doctor's Guide, 10/8/02
• Lexapro (Escitalopram Oxalate) Is Now Available In Pharmacies Nationwide For The Treatment Of Major Depressive Disorder - Doctor's Guide, 9/5/02
• Escitalopram Effective as First-Line Treatment of Severe Depression - Doctor's Guide, 9/2/02
• FDA Approves Escitalopram for Major Depression - Clinical Psychiatry News, 9/02
• Lexapro (Escitalopram Oxalate) Approved As Maintenance Treatment For Major Depressive Disorder - Doctor's Guide, 8/29/02
• Lower Depression Relapse, Continued Improvement Seen With Continued Escitalopram - Doctor's Guide, 8/29/02
• Escitalopram Safe and Effective for Patients Switched from Citalopram to Escitalopram - Doctor's Guide, 8/29/02
• Escitalopram Safe, Effective in the Treatment of Generalized Anxiety Disorder - Doctor's Guide, 8/29/02
• New Antidepressant Awaited, But Little Proof It's Much Better - Intelihealth, 8/27/02
• New Antidepressant [Lexapro] Approved - WebMD, 8/16/02
• Researchers laud new antidepressant - CNN, 8/15/02
• Lexapro(TM), The Single-Isomer of Celexa(TM), Receives FDA Approval For the Treatment of Major Depression - Doctor's Guide, 8/15/02
• Escitalopram Shows Promise for Treatment of Panic Disorder - Doctor's Guide, 6/28/02
• Escitalopram Superior to Citalopram for Severe Depression - Doctor's Guide, 6/27/02
• Escitalopram Improves Depression In Patients Treated In Primary Care - Doctor's Guide, 5/30/02
• Escitalopram Is a Well Tolerated Selective Serotonin Reuptake Inhibitor - Doctor's Guide, 5/23/02
• Study Results Published In International Clinical Psychopharmacology Show Escitalopram Effectively Treats Depression In Primary Care Settings - Doctor's Guide, 4/27/02
• The Journal Of Clinical Psychiatry Reports Escitalopram Effective And Well Tolerated - Doctor's Guide, 4/26/02
• Lexapro (Escitalopram) Significantly More Effective Than Placebo in Social/Generalized Anxiety and Panic Disorders - Doctor's Guide, 3/22/02
• FDA Issues Approvable Letter for Lexapro (Escitalopram) for Major Depressive Disorder - Doctor's Guide, 1/24/02
• Escitalopram and Citalopram Appear Safe, Effective for Depression - Doctor's Guide, 7/5/01
• Escitalopram Shows Promise For Treatment of Major Depressive Disorder - Doctor's Guide, 5/9/01 - "a single isomer of citalopram and a more potent and selective serotonin reuptake inhibitor (SSRI)"
• Escitalopram, New Generation Selective Serotonin Reuptake Inhibitor, Promising In Major Depressive Disorder - Doctor's Guide, 12/13/00

Abstracts:

• A Markov cost-utility analysis of escitalopram and duloxetine for the treatment of major depressive disorder - Curr Med Res Opin. 2008 Mar 7 - "quality adjusted life weeks (QALWs) ... This analysis suggests that escitalopram was more effective in terms of QALWs and less costly than duloxetine for treatment of depression" - See escitalopram at OffshoreRx1.com.
• Which antidepressants have demonstrated superior efficacy? A review of the evidence - Int Clin Psychopharmacol. 2007 Nov;22(6):323-329 - "Criteria were defined to judge the strength of evidence. Two pivotal studies in moderate-to-severe major depressive disorder that demonstrate superiority on the primary efficacy measure, or alternatively one pivotal study supported by consistent results from meta-analyses, was considered to constitute evidence for definite superiority. Three antidepressants met these criteria: clomipramine, venlafaxine, and escitalopram. Three antidepressants were found to have probable superiority: milnacipran, duloxetine, and mirtazapine. Only escitalopram was found to have definite superiority in the treatment of severe depression; probable superiority was identified for venlafaxine and possible superiority for milnacipran and clomipra"
• Escitalopram versus venlafaxine XR in the treatment of depression - Int Clin Psychopharmacol. 2006 Sep;21(5):297-309 - "treatment with 20 mg/day escitalopram resulted in a statistically significantly (P<0.05) higher remission rate at week 8 (47%) than treatment with venlafaxine XR (29%) ... The relative benefit of escitalopram versus venlafaxine XR was 1.46, indicating that a patient was more likely to benefit from treatment with escitalopram. The proportions of patients who withdrew owing to adverse events were 7.5% in the escitalopram group and 11.2% in the venlafaxine XR group" - See Escitalopram 20mg (Generic Equivalent of Lexapro 20mg) - OffshoreRx1.com.
• A comparative study of the efficacy of long-term treatment with escitalopram and paroxetine in severely depressed patients - Curr Med Res Opin. 2006 Jul;22(7):1331-41 - "Escitalopram is significantly more effective than paroxetine in the long-term treatment of severely depressed patients"
• Comparison of the Effects of Citalopram and Escitalopram on 5-Ht-Mediated Neuroendocrine Responses - Neuropsychopharmacology. 2004 May 5 - "both citalopram and escitalopram increased salivary and plasma cortisol levels with no evidence of consistent differences between them"