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Anti-aging Research >
Antidepressants & Psychotropics > Duloxetine
Cymbalta (duloxetine)
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Alternative News:
News & Research:
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Cymbalta (duloxetine Hcl) - rxlist.com
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Depression drug may relieve pain from breast cancer treatment - Science
Daily, 12/11/10
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Antidepressant Cymbalta Eases Back Pain - WebMD, 2/5/20
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Duloxetine Treatment and Rate of Sexual Dysfunction in Patients With
Depression - Doctor's Guide, 5/26/09
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Duloxetine Effective for Knee Osteoarthritis Pain - Doctor's Guide,
1/31/09
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Analysis Shows Sertraline, Escitalopram More Effective Than 10 Other
New-Generation Antidepressants - Doctor's Guide, 1/29/09 -
"Sertraline and escitalopram were found to be the
best antidepressants overall in terms of efficacy and acceptability.
Sertraline was more efficacious than duloxetine (by 30%); than both
duloxetine and fluvoxamine (by 27% for both); 25% fluoxetine (by 25%);
paroxetine (by 22%); and reboxetine (by 85%) ... Escitalopram was more
efficacious than duloxetine (by 33%); fluoxetine (by 32%); fluvoxamine (by
35%); paroxetine (by 30%); and reboxetine (by 95%). As with sertraline and
escitalopram, mirtazapine and venlafaxine were also more efficacious than
these other drugs ... However, escitalopram and sertraline showed the best
profile of acceptability, leading to significantly fewer discontinuations of
treatment than did duloxetine, fluvoxamine, paroxetine, reboxetine, and
venlafaxine"
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Study: Cymbalta May Cut Chronic Low Back Pain - WebMD, 8/26/08
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Cymbalta Approved for
Fibromyalgia - Medscape, 6/20/08
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Duloxetine Does Not Relieve Painful Physical Symptoms In Depression,
According To Current Analysis - Science Daily, 1/21/08
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FDA Approves Cymbalta® for Maintenance Treatment of Major Depressive
Disorder - Doctor's Guide, 11/30/07
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Recent Trials in Generalised Anxiety Disorder Highlight Escitalopram,
Duloxetine, and Anticonvulsants - Doctor's Guide, 11/21/07
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Duloxetine May Improve Patients' Sleep Quality - Clinical Psychiatry
News, 11/07
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Duloxetine Improves Functioning and Quality of Life in Patients with Anxiety
Disorder - Doctor's Guide, 4/3/07
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Duloxetine is Effective for Anxiety - Doctor's Guide, 4/2/07
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FDA Approves Duloxetine for Anxiety - Clinical Psychiatry News, 3/07
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Duloxetine May Alleviate Both Pain and General Anxiety Disorder -
Doctor's Guide, 2/12/07
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Duloxetine Treatment of Neuropathic Pain May Affect Glycemic Control -
Medscape, 1/3/07
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Duloxetine Safe for Long-Term Management of Diabetic Peripheral Neuropathic
Pain - Doctor's Guide, 6/28/06
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Duloxetine May Impair Metabolic Control in Patients With Diabetic
Neuropathic Pain - Doctor's Guide, 6/12/06
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Sexual Functioning in Long-term Treatment of MDD: Duloxetine, Escitalopram,
and Placebo - Doctor's Guide, 5/23/06 -
"the study found a statistically significant
worsening of sexual functioning as measured by the Changes in Sexual
Functioning Questionnaire (CSFQ) for escitalopram versus placebo at 4 weeks
(P </=.01) while duloxetine was not statistically different from placebo"
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Lilly Submits Supplemental New Drug Application for Generalized Anxiety
Disorder - Doctor's Guide, 5/9/06
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Patients Taking Cymbalta Also Reported Reduced Painful Physical Symptoms and
Improved Functioning - Doctor's Guide, 3/24/06
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Duloxetine Improves Functional Outcomes in Diabetic Neuropathic Pain -
Doctor's Guide, 3/2/06
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Duloxetine Reduces Fibromyalgia Pain - Doctor's Guide, 2/27/06
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Study Finds Cymbalta as Safe and Well-Tolerated as Routine Drug Treatments
for Diabetic Nerve Pain - Doctor's Guide, 2/14/06
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Duloxetine Lifts Arthritis Pain, Aids Cognition - Clinical Psychiatry
News, 1/06
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Duloxetine: A Balanced and Selective Norepinephrine and Serotonin-Reuptake
Inhibitor - Medscape, 12/14/05
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New Study Suggests Cymbalta (Duloxetine Hydrochloride) Reduced Depression
Symptoms at Least as Fast As a Leading Competitor - Doctor's Guide,
12/13/05
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Duloxetine Improves Cognition in Elderly Patients with Major Depressive
Disorder - Doctor's Guide, 11/10/05
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Liver Damage Data Prompt New Alert on Duloxetine Label - Clinical
Psychiatry News, 11/05
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FDA Issues Liver Warning for Cymbalta - WebMD, 10/17/05
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Duloxetine (Cymbalta) Treatment for Diabetic Peripheral Neuropathic Pain
Shows Efficacy at Week 1: Presented at ADA - Doctor's Guide, 6/15/05
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Duloxetine (Cymbalta) Improves Depression and Cognition Measures in
Depressed Elderly - Doctor's Guide, 5/31/05
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Duloxetine (Cymbalta) Effective for Women With Fibromyalgia, With or Without
Comorbid Depression - Doctor's Guide, 5/30/05
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Duloxetine (Cymbalta) Appears Effective for Comorbid Anxiety in Geriatric
Depression - Doctor's Guide, 5/26/05
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Duloxetine Appears Safe for Hypertensive Patients With Diabetic Neuropathic
Pain - Doctor's Guide, 5/18/05
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Duloxetine Reduces Diabetic Neuropathic Pain, Even Without Comorbid
Depression - Doctor's Guide, 2/28/05
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FDA Approves Duloxetine in Speedy Review - Clinical Psychiatry News,
11/04
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Yentreve (Duloxetine) Appears to Reduce Frequency of Urinary Incontinence
Episodes in Women - Doctor's Guide, 9/24/04
- Duloxetine Effective
in Fibromyalgia - Medscape, 9/10/04
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Antidepressant Duloxetine Aids in Improving Symptoms, Relieving Pain in
Fibromyalgia - Doctor's Guide, 9/9/04
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FDA Grants Priority Approval to Antidepressant Cymbalta (Duloxetine) to
Treat Diabetic Peripheral Neuropathic Pain - Doctor's Guide, 9/7/04
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Duloxetine Gains FDA Approval for Major Depression - Clinical Psychiatry
News, 9/04
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Duloxetine (Yentreve) Significantly Improves Stress Urinary Incontinence
- Doctor's Guide, 8/26/04
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Cymbalta (Duloxetine), Treatment for Major Depression, Now Available in US
- Doctor's Guide, 8/26/04 -
"Cymbalta® (duloxetine HCl; pronounced SIM-BALL-TA),
a new treatment for major depression, is now available by prescription in
pharmacies across the United States"
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New Antidepressant Cymbalta (Duloxetine) Launched in US - Doctor's
Guide, 8/24/04
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FDA Approves Cymbalta (Duloxetine) for Treatment of Depression -
Doctor's Guide, 8/4/04 - "Cymbalta, a balanced and potent reuptake
inhibitor of serotonin and
norepinephrine"
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Duloxetine Appears to Improve Stress Urinary Incontinence in Women -
Doctor's Guide, 7/29/04
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Duloxetine Effective for Diabetic Neuropathic Pain - Clinical Psychiatry
News, 6/04
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Duloxetine Benefits Women With Fibromyalgia - Clinical Psychiatry News,
6/04
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Duloxetine May Be Effective for Treatment of Fibromyalgia Symptoms -
Doctor's Guide, 3/5/04
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Duloxetine May Be Effective for Treatment of Pain Associated With Diabetic
Neuropathy - Doctor's Guide, 3/5/04
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Cymbalta (Duloxetine) Demonstrates High Tolerability, Safety In Long-Term
Study - Doctor's Guide, 11/20/03
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New Global Study of Duloxetine Effect on Stress Incontinence Supports
Earlier Studies' Efficacy Findings - Doctor's Guide, 10/14/03
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Higher Depression Remission Rates With Duloxetine Than Selective Serotonin
Reuptake Inhibitors - Doctor's Guide, 10/13/03
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Duloxetine Appears to Ease Pain of Diabetic Neuropathy - Clinical
Psychiatry News, 10/03
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Duloxetine Treatment Causes Women with Severe Stress Urinary Incontinence to
Reconsider Surgery - Doctor's Guide, 9/16/03
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Duloxetine Achieves Short- and Long-Term Improvement of Stress Urinary
Incontinence - Doctor's Guide, 9/15/03
- Duloxetine Safe,
Effective in Stress Urinary Incontinence - Medscape, 9/12/03
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Duloxetine Shows Promise in Depression, Pain Management - Clinical
Psychiatry News, 9/03
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Duloxetine Relieves Pain Associated With Diabetic Neuropathy - Doctor's
Guide, 8/26/03
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Higher Rates Of Remission, Lower Incidence Of Sexual Dysfunction
Demonstrated In Patients Taking Cymbalta (Duloxetine) - Doctor's Guide,
6/3/04
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Venlafaxine Beats Selective Serotonin-Reuptake Inhibitors in Remission of
Depression - Doctor's Guide, 5/22/03 -
"The results of this largest-of-all comparative
study of venlafaxine and
other agents supports the conclusions of other investigators that,
compared to other SSRIs, venlafaxine helps patients achieve remission of
symptoms at relatively higher rates" - Note: Venlafaxine increases
both serotonin and
norepinephrine, as does mirtazapine
and the investigational drug duloxetine.
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Duloxetine Appears to Relieve Pain In Patients With Depression -
Clinical Psychiatry News, 5/03
- New
Antidepressants Target Aches and Pains, Too - Psychiatric News, 4/18/03
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Investigative Duloxetine Helps Physical Pain in Depression, Ups Remission
Rate - Doctor's Guide, 2/20/03
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Duloxetine Resolves Pain in Depressed Patients - Doctor's Guide, 2/21/03
- Duloxetine
Antidepressant Action Begins in One Week - Medscape, 11/12/02
- New
Antidepressant [Cymbalta] Works Faster - WebMD, 11/11/02 -
"Cymbalta affects two different brain chemical
messengers -- serotonin and norepinephrine"
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Duloxetine Effective and Safe in Treatment of Major Depression in Elderly
- Doctor's Guide, 11/4/02
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Antidepressant Duloxetine Considered ‘Approvable’ by FDA - Clinical
Psychiatry News, 10/02
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Novel Antidepressant Therapies Near Approval - Clinical Psychiatry News,
10/02
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Meta-Analysis Shows Duloxetine Safe and Tolerable for Major Depression -
Doctor's Guide, 9/25/02
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Duloxetine 60mg Once Daily Efficacious For Emotional and Physical Symptoms
of Depression - Doctor's Guide, 9/24/02
- Duloxetine Controls
Symptoms of Stress Urinary Incontinence - Medscape, 7/23/02
- Drug Shows
Promise for Bladder Problems - WebMD, 7/22/02
- Duloxetine Has Little
Effect on Body Weight - Doctor's Guide, 5/24/02
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Duloxetine Effective Against Emotional and Physical Symptoms of Depression
- Doctor's Guide, 5/21/02
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Duloxetine Dampens Depression, Comorbid Pain - Clinical Psychiatry News,
2/02
- Duloxetine Shown to
Significantly Reduce Symptoms of Depression, Including Physical Symptoms
- Doctor's Guide, 11/19/01
- Duloxetine Shows Efficacy
for Stress Urinary Incontinence - Doctor's Guide, 10/29/01
Abstracts:
-
A
Markov cost-utility analysis of escitalopram and duloxetine for the
treatment of major depressive disorder - Curr Med Res Opin. 2008 Mar 7 -
"quality adjusted life weeks (QALWs) ... This
analysis suggests that escitalopram was more effective in terms of QALWs and
less costly than duloxetine for treatment of depression" - See
escitalopram at
OffshoreRx1.com.
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Evidence for the efficacy of duloxetine in treating mild, moderate, and
severe depression - Int Clin Psychopharmacol. 2007 Nov;22(6):348-55
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Which antidepressants have demonstrated superior efficacy? A review of the
evidence - Int Clin Psychopharmacol. 2007 Nov;22(6):323-329 -
"Criteria were defined to judge the strength of
evidence. Two pivotal studies in moderate-to-severe major depressive
disorder that demonstrate superiority on the primary efficacy measure, or
alternatively one pivotal study supported by consistent results from
meta-analyses, was considered to constitute evidence for definite
superiority. Three antidepressants met these criteria: clomipramine,
venlafaxine, and escitalopram. Three antidepressants were found to have
probable superiority: milnacipran, duloxetine, and mirtazapine. Only
escitalopram was found to have definite superiority in the treatment of
severe depression; probable superiority was identified for venlafaxine and
possible superiority for milnacipran and clomipra"
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A randomized, double-blind comparison of duloxetine and venlafaxine in the
treatment of patients with major depressive disorder - J Psychiatr Res.
2007 Apr 17 - "were no significant differences
between duloxetine 60mg/day and venlafaxine 150mg/day as measured by GBR
assessment at the end of 6 weeks (-1.418 vs. -1.079, P=0.217) or 12 weeks
... Nausea was the most common treatment-emergent adverse event (TEAE) for
both drugs, and was significantly higher with duloxetine 60mg/day compared
to venlafaxine 150mg/day during the first 6 weeks of treatment"
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Duloxetine in the treatment of depression: a double-blind placebo-controlled
comparison with paroxetine - J Clin Psychopharmacol. 2004
Aug;24(4):389-99 -
"Duloxetine 80 mg/d was superior to placebo for most
other measures, including overall pain severity, and was superior to
paroxetine on 17-item Hamilton Depression Rating Scale improvement (by 2.39
points; 95% CI 0.14, 4.65; P = 0.037) and estimated probability of
remission"
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