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Anti-aging Research >
Antidepressants & Psychotropics > Zoloft®
(sertraline hydrochloride)
Zoloft® (sertraline Hydrochloride)
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News & Research:
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Zoloft (sertraline Hcl) - rxlist.com
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Zoloft - Reuters
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Analysis Shows Sertraline, Escitalopram More Effective Than 10 Other
New-Generation Antidepressants - Doctor's Guide, 1/29/09 -
"Sertraline and escitalopram were found to be the
best antidepressants overall in terms of efficacy and acceptability.
Sertraline was more efficacious than duloxetine (by 30%); than both
duloxetine and fluvoxamine (by 27% for both); 25% fluoxetine (by 25%);
paroxetine (by 22%); and reboxetine (by 85%) ... Escitalopram was more
efficacious than duloxetine (by 33%); fluoxetine (by 32%); fluvoxamine (by
35%); paroxetine (by 30%); and reboxetine (by 95%). As with sertraline and
escitalopram, mirtazapine and venlafaxine were also more efficacious than
these other drugs ... However, escitalopram and sertraline showed the best
profile of acceptability, leading to significantly fewer discontinuations of
treatment than did duloxetine, fluvoxamine, paroxetine, reboxetine, and
venlafaxine"
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FDA Approves Generic Zoloft - WebMD, 6/30/06
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Mirtazapine Betters Major SSRIs for Treatment of Depression - Doctor's
Guide, 5/27/05 - "A meta-analysis of clinical trials
involving more than 2,500 subjects suggests that treatment of depression
with mirtazapine (Remeron) results in a more rapid onset of clinical
improvement compared to treatment with fluoxetine, paroxetine, and
sertraline (all SSRIs)" - See Remeron (mirtazapine) at
OffshoreRx1.com.
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Sertraline HCl and Venlafaxine-XR Show Comparable Efficacy in Major
Depression - Doctor's Guide, 6/23/04
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Mirtazapine More Effective Than Sertraline On Veterans' Post-Traumatic
Stress Disorder - Doctor's Guide, 10/14/03
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Sertraline Shows Short-Term Safety, Efficacy for Major Depressive Disorder
in Children and Adolescents - Doctor's Guide, 8/26/03
- Zoloft
Effective in Childhood Depression - WebMD, 8/26/03
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Sertraline May Enhance Antiplatelet Activity in Patients With Acute Coronary
Syndromes - Doctor's Guide, 8/19/03
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Long-Term Sertraline Effective in Treating Obsessive-Compulsive Disorder in
Children and Adolescents - Doctor's Guide, 8/11/03
- Antidepressant
May Prevent Blood Clots - WebMD, 8/11/03
- Zoloft Safely
Treats Depression in People with Alzheimer's Disease - WebMD, 7/29/03
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Sertraline Is Effective in Treatment of Depression of Older Adults -
Doctor's Guide, 7/21/03
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Sertraline: Less Postpartum Depression Recurrence - Clinical Psychiatry
News, 6/03
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Sertraline Associated with Cognitive and Behavioural Improvements in Mild
Alzheimer's Disease - Doctor's Guide, 5/17/03
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Patients with Non-melancholic Depression Might Respond Better to Sertraline
than Imipramine - Doctor's Guide, 4/17/03
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Combining Prolonged Exposure With Sertraline Enhances Drug Benefits of Post
Traumatic Stress Disorder - Doctor's Guide, 4/1/03
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Sertraline Equally Effective In Men And Women With Generalized Anxiety
Disorder - Doctor's Guide, 4/1/03
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Sertraline Treats Psychic Anxiety Symptoms Associated with a Range of
Depressive and Anxiety Disorders - Doctor's Guide, 4/1/03
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Sertraline Improves Quality of Life in Patients With Generalized Anxiety
Disorder - Doctor's Guide, 4/1/03
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Sertraline Effective for Treating Social Anxiety Disorder - Doctor's
Guide, 3/31/03
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Sertraline Better Tolerated than Paroxetine in Panic Disorder - Doctor's
Guide, 3/30/03
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Sertraline May Not Reduce Cognitive Deficits in Elderly Patients with
Depression and Cognitive Impairment - Doctor's Guide, 3/4/03
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FDA Approves Zoloft (Sertraline) For Treatment Of Social Anxiety Disorder
- Doctor's Guide, 2/11/03
- SSRIs May Increase
Risk of Gastrointestinal Bleeding - Medscape, 1/17/03 -
"Selective serotonin reuptake inhibitors (SSRIs)
are associated with an increased risk of gastrointestinal (GI) bleeding,
especially when combined with nonsteroidal anti-inflammatory drugs (NSAIDs)"
- Examples of SSRIs are
Prozac,
Paxil and Zoloft.
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Pfizer Issues Warning on Sertraline + Pimozide - Clinical Psychiatry
News, 1/03
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Long-Term Sertraline Effective, Safe in Children - Clinical Psychiatry
News, 1/03
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Luteal Phase Sertraline Curbs Premenstrual Dysphoric Disorder - Doctor's
Guide, 12/23/02
- Sertraline Helpful in
Premenstrual Dysphoric Disorder - Medscape, 12/9/02
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Mirtazapine May Be Superior to Sertraline in Onset Time, Symptom Reduction
among Patients with Major Depression - Doctor's Guide, 11/4/02
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Twice A Day Sertraline Effective In Adolescents - Doctor's Guide,
10/22/02
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Setraline Effective, Safe for Major Depression in Children - Doctor's
Guide, 10/11/02
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Sertraline Effective, Well-Tolerated in Geriatric Patients With and Without
Comorbidity - Doctor's Guide, 10/9/02
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Sertraline Effective For Premature Ejaculation In Some Men - Doctor's
Guide, 9/30/02
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Sertraline Effective for Major Depression in Patients with Acute Myocardial
Infarction or Unstable Angina - Doctor's Guide, 8/14/02
- Sertraline Safe,
Effective in Patients With Recent MI, Angina - Medscape, 8/14/02
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Study Suggests Anti-Depressant Is Safe In Some Heart Patients -
Intelihealth, 8/13/02
- High-Dose Sertraline
Effective for Obsessive-Compulsive Disorder when Lower Doses Fail -
Doctor's Guide, 6/28/02
- Sertraline May Prevent
Depression and Improve Cognitive Function within One Year of Stroke -
Doctor's Guide, 6/27/02
- Sertraline Improves
Symptoms and Quality of Life in Patients with Moderate to Severe Social
Phobia - Doctor's Guide, 6/26/02
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Sertraline May Be Safe and Effective for Moderate to Severe PMS -
Doctor's Guide, 6/26/02
- St. John's Wort as
Effective as Zoloft® against Depression - New Hope Natural Media Online,
6/13/02 -
"St. John's wort (SJW),
a popular herbal remedy, is at least as effective as the prescription drug
sertraline (Zoloft®) in the treatment of
depression and causes fewer side effects, according to a new study
published in Canadian Family Physician (2002;48:905–8). This report confirms
dozens of other studies demonstrating SJW is an effective treatment for
mild-to-moderate depression, and contradicts two controversial studies
suggesting the herb is of little or no benefit ... After 12 weeks, the
severity of depression had decreased by an average of 50.2% in the SJW group
and by 41.6% in the sertraline group"
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Sertraline Effects Differ in Depressed Women - Doctor's Guide, 6/6/02 -
"The investigators say four-week sertraline therapy
increased plasma cortisol levels in the
depressed patients"
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Sertraline Effective for Generalized Anxiety Disorder - Doctor's Guide,
5/22/02
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Sertraline Beats Fluoxetine for Severe Depression - Doctor's Guide,
5/22/02
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Results From A New Study Show Zoloft (Sertraline) Effective In Treatment Of
Social Anxiety Disorder - Doctor's Guide, 5/21/02
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Zoloft (Sertraline HCl) Receives FDA Approval For Treatment Of Premenstrual
Dysphoric Mood Disorder - Doctor's Guide, 5/21/02
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St. John's Wort: Effective, with Caveats - Nutrition Science News, 3/02
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"Using the Hamilton Rating Scale for Depression, 47
percent of those taking
St. John's wort improved compared with 40
percent of those taking the sertraline
... Hyperforin increases the effectiveness of
norepinephrine, dopamine, L-glutamate,
and gamma-amino butyric acid (GABA), as well as
serotonin. Researchers in the Department of Pharmacology at the
University of Frankfurt in Germany concluded, "no other antidepressant
compound exhibits a similar broad uptake-inhibiting profile.""
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Sertraline Impact on Platelets Appears to Explain Reduction of
Cardiovascular Events - Doctor's Guide, 3/18/02
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Long-Term Sertraline Improves Pediatric OCD - Clinical Psychiatry News,
2/02
- Research Fails to Uncover
Factors to Predict Response to Sertraline for Social Phobia - Doctor's
Guide, 11/18/01
- Depression After an Acute
Coronary Syndrome Improves with Sertraline - Doctor's Guide, 11/12/01
- FDA Approves Zoloft
(Sertraline) For Long-Term Use in Post-Traumatic Stress Disorder -
Doctor's Guide, 8/16/01
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Sertraline And Imipramine Reduce Anxiety In Depressed Patients -
Doctor's Guide, 3/15/01
- Zoloft (Sertraline)
Significantly Reduces Posttraumatic Stress Disorder Symptoms - Doctor's
Guide, 4/12/00
- Sertraline Effective For
Adolescent Anxiety Disorders - Doctor's Guide, 10/22/99
Abstracts:
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Comparing Perika St.
John's Wort and Sertraline for Treatment of Posttraumatic Stress Disorder in
Mice - J Diet Suppl. 2019 Feb 18:1-9 - "exaggerated
acoustic startle response (ASR) ... Thirty-six mice were tested for baseline
ASR, then they were exposed to rats in a predator exposure paradigm known to
induce PTSD-like symptoms. Mice were randomly divided into three groups for
treatment (control, sertraline, SJW), and ASR was retested one week later.
One-way ANOVAs found no significant group differences in ASR amplitude at
baseline but a significant effect of Treatment Group after predator exposure,
F(2, 33) = 5.645, p = .008, n2 = .225, when SJW-treated mice had ASR amplitudes
that were significantly lower than sertraline-treated mice (by 27%) and controls
(by 26%). Fecal boli counts showed a similar pattern, with lowest counts in
SJW-treated mice. These results suggest SJW could be considered for studies of
PTSD treatment in humans as well" - See
Perika St. John's Wort at Amazon.com.
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Double-blind Switch Study of Imipramine or Sertraline Treatment of
Antidepressant-Resistant Chronic Depression - Archives of General
Psychiatry, 3/02
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Comparison of an extract of hypericum (LI 160) and sertraline in the
treatment of depression: a double-blind, randomized pilot study -
Medline/Clin Ther 2000 Apr;22(4):411-9, 4/00 -
"Clinical response (defined as a > or =50% reduction
in HAM-D scores) was noted in 47% of patients receiving hypericum and 40% of
those receiving sertraline ... The [LI 160]
hypericum extract was at least as effective as sertraline in the treatment
of mild to moderate depression in a small group of outpatients"
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