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> Clozaril (clozapine)
Clozaril (clozapine)
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News & Research:
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Clozaril (clozapine) - rxlist.com
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Comparison Of Antipsychotic Treatments In Adolescents With Schizophrenia
- Science Daily, 2/28/08 - "The researchers
discovered that clozapine was approximately twice as likely to produce a
treatment response as olanzapine"
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Using Clozapine in Agitated Dementia Patients - Clinical Psychiatry
News, 11/07
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Most
Effective Antipsychotic Drug Has Serious Health Consequences - Science
Daily, 7/16/06
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Schizophrenia drug 'health risk' - BBC News, 7/1/06
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Ziprasidone as Effective as Clozapine in Study of Difficult-to-Treat
Patients With Schizophrenia - Doctor's Guide, 5/30/06
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Comparative Efficacy and Safety of Ziprasidone and Clozapine in
Treatment-Refractory Schizophrenia - Doctor's Guide, 5/26/06
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FDA Approves Two Monitoring Changes For Clozapine Patients - Clinical
Psychiatry News, 10/05
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Two Atypical Anti-psychotic Drugs May Be Associated With An Increased Risk
Of Diabetes For Patients With Schizophrenia - Science Daily, 1/5/05
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Clozapine, Olanzapine May be Associated with Increased Risk of Diabetes for
Patients with Schizophrenia - Doctor's Guide, 1/3/05
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Reducing Clozapine's Metabolic Side Effects - Clinical Psychiatry News,
11/04
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Some Anti-Psychotic Medications May Trigger Diabetes - Science Daily,
10/8/04 -
"The rate is five to 10 times higher than the
estimated rate of 6.3 cases per 1,000 in the general U.S. population"
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FazaClo (Clozapine) Orally Disintegrating Tablets Available in US for
Patients Unresponsive to Standard Schizophrenia Treatments - Doctor's
Guide, 7/21/04
- Clozapine Effective
in Drug-Induced Psychosis in Parkinson's Disease - Medscape, 5/14/04
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Clozapine Still Stands Out in Schizophrenia Tx - Clinical Psychiatry
News, 5/04
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Mirtazapine Plus Clozapine Appears to Improve Negative Symptoms of
Schizophrenia - Doctor's Guide, 4/21/04
- Clozapine Associated
With Risk of Hyperglycemia and Diabetes - Medscape, 4/8/04
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Clozapine May Impair Glucose Control in Patients With Schizophrenia -
Doctor's Guide, 3/2/04
- Clozapine May Improve
Levodopa-Induced Dyskinesias in Parkinson's Disease - Doctor's Guide,
2/12/04
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Clozapine Effective for Controlling Dyskinesias in People with Severe
Parkinson's - Doctor's Guide, 2/10/04
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Clozapine Treatment Difficult to Maintain Long Term But Highly Effective
When Maintained - Doctor's Guide, 11/3/03
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Antipsychotic-Induced Metabolic Syndrome Proves Costly - Clinical
Psychiatry News, 9/03
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Case Study Highlights Risk of Dilated Cardiomyopathy with Clozapine Use
- Doctor's Guide, 9/10/03
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Fewer WBC Checks Urged in Clozapine Cases - Clinical Psychiatry News,
7/03
- Schizophrenia
Drugs Linked to Diabetes - WebMD, 6/3/03 -
"close to 25% of them developed high blood sugar
levels while taking Clozaril, the first of these newer schizophrenia
medications -- called "atypical
antipsychotics." ... people with
schizophrenia have a four- to six-fold risk of
diabetes compared with the general population ... One possible
explanation: Those with schizophrenia typically have higher levels of
cortisol, known as the "stress hormone," because the body releases it
during times of agitation. And high cortisol levels can cause problems in
the way blood sugar is metabolized" - See my
cortisol page
for possible ways to reduce it.
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Patients Can Switch Safely from Clozaril to Generic Clozapine - Doctor's
Guide, 5/22/03
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Antipsychotics Effective for Elderly Patients With Dementia -
Psychiatric News, 4/18/03 -
"atypical
antipsychotics have been used to alleviate deteriorating behavioral
symptoms in dementia patients, such as agitation and aggression. New
research that she cited shows some atypical antipsychotics can actually
improve cognition through activating the release of acetylcholine in the
cortex. Clozapine, olanzapine, and
risperidone, she reported, robustly increased acetylcholine release in
the cortex, while ziprasidone only
moderately increased levels, compared with
haloperidol and thioridazine, which did not elevate acetylcholine levels
at all ... atypical antipsychotics increase cortical dopamine and
cholinesterase inhibitors at the very least increase cortical
acetylcholine action, leading to an improvement in memory and thinking, as
well as improvement in psychosis and behavior"
- Antipsychotics and
Glucose Dysregulation: Their Relationship to Treatment Decisions -
Psychiatric Times, 3/03
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Smoking-Related Anti-psychotic Dose Adjustment Could Improve Response -
Doctor's Guide, 3/10/03 -
"Clozapine was largely metabolised by the
cytochrome P450 enzyme CYP1A2. Smoking powerfully induced this enzyme's
activity"
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Antipsychotics Raise Glucose, Cholesterol Levels In Schizophrenics -
Doctor's Guide, 2/25/03 -
"Clozapine, olanzapine and haloperidol are
associated with increased plasma glucose level, and clozapine and olanzapine
with raised cholesterol"
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Clozapine Monitoring Recommended In Schizophrenia Maintenance Therapy -
Doctor's Guide, 2/17/03
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Clozapine Appears Better Therapy For Patients With Parkinson's Disease And
Psychosis - Doctor's Guide, 2/17/03
- Clozapine Reduces
Suicide Attempts in Schizophrenic Patients - Medscape, 1/16/03
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Clozapine Can Reduce Suicide Risk, FDA Says - Clinical Psychiatry News,
1/03
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Some Antipsychotics May Be Tied To Increased Type 2 Diabetes Risk -
Clinical Psychiatry News, 1/03 -
"the risk was increased by 3.1 among those on
olanzapine (Zyprexa), 7.44 times among those on clozapine, 2.13 among those
on high-potency conventional antipsychotics such as haloperidol and
fluphenazine, and by 3.46 times among those on low-potency conventional
antipsychotics such as chlorpromazine and thioridazine"
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Clozaril (Clozapine) Reduces Risk Of Suicidal Behavior Among Patients With
Schizophrenia, Schizoaffective Disorder - Doctor's Guide, 1/14/03
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FDA Approves Clozaril (Clozapine) To Reduce The Risk Of Suicidal Behavior
- Doctor's Guide, 12/19/02
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FDA Committee Recommends Approval for Clozaril to Treat Suicidal Behavior --
Drug Could Be First Ever With Indication - Doctor's Guide, 11/5/02
- Clozapine Reduces
Suicidality in Schizophrenia - Doctor's Guide, 6/26/02
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Possible Genetic Linkage Cited in Antipsychotic Drug Weight Gain -
Doctor's Guide, 6/13/02
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Quetiapine, Clozapine May Benefit Patients with Parkinson's Disease and
Hallucinations - Doctor's Guide, 4/19/02
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Acute Tryptophan Depletion in Schizophrenic Patients Treated With Clozapine
- Archives of General Psychiatry, 3/02
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New Clozapine Labeling Warns of Myocarditis Risk - Clinical Psychiatry
News, 3/02
- Focus on Clozapine
- Medscape, 2/02
- Significant Risk of
Cardiovascular Toxicity Associated with Schizophrenia Drug Clozaril
(Clozapine) - Doctor's Guide, 1/18/02
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Olanzapine's And Clozapine's Effect On Weight Gain Related To Insulin And
Leptin - Doctor's Guide, 3/26/01 -
"the median insulin level was significantly higher
in olanzapine patients ... In the clozapine group, insulin levels were
positively correlated to the drug serum concentration"
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Risperidone, Clozapine Seem Equally Effective In Refractory Schizophrenia
- Doctor's Guide, 10/25/00
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