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Return to cortisol page
Effects of Remeron (mirtazapine) on
cortisol
I went to the library and tracked down the data in the "Effects
of mirtazapine on growth hormone, prolactin, and cortisol secretion in healthy
male subjects" study. In brief, they took 18 healthy 20 to 35 year old
males. They drew blood samples one hour prior. At time zero, they
took a blood sample and gave either 15 mg of mirtazapine or a placebo and took
blood samples again every 30 minutes out to 240 minutes. -60 was at 8 AM.
Below is the table and graph of the results.
I felt that cortisol of placebo patient #1 was out of the
norm. The yellow line on the graph represents the results not counting
that patient.
| |
Time (minutes) - (-60 is 8
AM) |
| |
-60 |
0 |
30 |
60 |
90 |
120 |
150 |
180 |
210 |
240 |
Patient
Number |
Cortisol ug/100ml after
mirtazapine (15 mg orally)
|
| 1 |
24.69 |
15.41 |
12.98 |
9.85 |
8.53 |
6.53 |
5.62 |
4.78 |
4.03 |
3.33 |
| 2 |
24.11 |
14.25 |
10.40 |
8.88 |
7.57 |
6.02 |
5.27 |
4.29 |
4.39 |
3.75 |
| 3 |
29.23 |
21.26 |
14.74 |
9.68 |
6.88 |
5.38 |
3.84 |
3.65 |
4.46 |
6.50 |
| 4 |
14.18 |
8.20 |
9.39 |
7.11 |
5.13 |
4.43 |
3.59 |
3.16 |
7.95 |
4.41 |
| 5 |
16.94 |
16.62 |
11.04 |
8.48 |
5.74 |
4.83 |
4.12 |
3.49 |
4.91 |
4.64 |
| 6 |
14.73 |
8.22 |
8.57 |
5.92 |
4.05 |
3.55 |
3.07 |
2.18 |
2.08 |
1.94 |
| 7 |
18.01 |
11.85 |
10.33 |
8.27 |
5.93 |
5.31 |
11.64 |
7.39 |
5.92 |
5.10 |
| 8 |
11.30 |
8.88 |
7.22 |
5.95 |
4.52 |
3.79 |
3.18 |
2.45 |
2.71 |
2.14 |
| Mean |
19.15 |
13.09 |
10.58 |
8.02 |
6.04 |
4.98 |
5.04 |
3.92 |
4.56 |
3.98 |
| |
Cortisol ug/100ml after placebo
|
| 1 |
38.24 |
24.56 |
20.14 |
19.64 |
19.06 |
18.87 |
16.19 |
14.00 |
13.64 |
12.34 |
| 2 |
28.68 |
15.02 |
13.18 |
11.34 |
9.87 |
10.28 |
11.98 |
12.49 |
11.77 |
11.54 |
| 3 |
23.44 |
15.10 |
12.82 |
12.99 |
11.82 |
9.29 |
11.08 |
9.33 |
10.47 |
7.90 |
| 4 |
18.86 |
13.07 |
12.40 |
11.08 |
8.77 |
7.58 |
6.91 |
13.75 |
15.49 |
13.19 |
| 5 |
13.80 |
9.71 |
7.96 |
8.95 |
6.24 |
6.38 |
5.59 |
6.54 |
5.79 |
6.81 |
| 6 |
24.90 |
16.32 |
13.22 |
15.18 |
17.52 |
15.69 |
13.14 |
13.06 |
12.11 |
10.08 |
| 7 |
18.31 |
15.10 |
12.06 |
11.39 |
10.39 |
10.59 |
10.79 |
9.25 |
9.39 |
10.81 |
| 8 |
10.19 |
7.18 |
6.36 |
4.78 |
5.77 |
8.46 |
9.14 |
7.25 |
5.83 |
8.48 |
| Mean |
22.05 |
14.51 |
12.27 |
11.92 |
11.18 |
10.39 |
10.00 |
10.58 |
10.56 |
10.14 |
Cortisol ug/100ml after placebo not
counting placebo patient #1 |
| Mean |
19.74 |
13.07 |
11.14 |
10.82 |
10.05 |
9.75 |
9.80 |
10.10 |
10.12 |
9.83 |
Related Study:
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