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Recent Longevity News for the week ending 10/27/21

Omega-3s Tame Inflammation in Elderly COVID-19 Patients - Medscape, 10/12/21 - "The patients, who had a median age of 81 years, were randomized to receive an intravenous infusion of an omega-3 polyunsaturated fatty acid (PUFA) emulsion containing 10 g of fish oil per 100 mL or a saline placebo ... Those who received the intravenous infusion had significant decreases from baseline to end of treatment in the neutrophil-to-lymphocyte ratio (NLR), indicating marked reductions in systemic inflammation ... In contrast, patients randomized to a saline placebo had no significant improvements in NLR" - See

Plant Polyphenols Lignans and Cardiovascular Disease - Medscape, 10/12/21 - "The evidence is building that there is an association between polyphenol intake and chronic disease, especially for CVD. Plant polyphenols may be important components of healthy plant-based diets that contribute to freedom from chronic diseases such as CVD, diabetes, and possibly cancer and so are associated with a reduction in all-cause mortality. However, although the associations are promising, it would be helpful to have trial data, both for total and individual polyphenols. At the same time, such trials would be difficult to undertake, and sustained adherence may not be possible to achieve even over short periods of time, as seen with the difficulty in increasing fruit and vegetable intake,[15] let alone adherence over the number of years as required to see chronic disease events. Perhaps an exception to this concern is the PREDIMED trial, in which foods were provided that are considered highly desirable, as nuts and olive oil, for the duration of the trial, and adherence was excellent."

Lower Thyroid Hormone Levels a Red Flag for Elevated Suicide Risk? - Medscape, 10/12/21 - "thyroid hormones are known to have a "profound" effect on mood and behavior ... Recent studies show "various degrees of hypothalamic-pituitary-thyroid axis dysregulation are associated with suicidal behavior" in patients with depression ... Fasting blood samples were also tested for free thyroxine (FT4), free triiodothyronine (FT3), and TSH levels ... Suicidal ideation was associated with higher scores on the PHQ-9 (15.5 vs 13.3; P = .085), and with lower TSH levels (1.54 IU/L vs 2.04 IU/L ... There were no significant associations between serum FT4 and FT3 levels and suicidal ideation"

Deaths linked to ‘hormone disruptor’ chemical costs billions in lost US productivity - Science Daily, 10/12/21 - "Daily exposure chemicals called phthalates, used in the manufacture of plastic food containers and many cosmetics, may lead to roughly 100,000 premature deaths among older Americans each year ... the new investigation of more than 5,000 adults between the ages of 55 and 64 showed that those with the highest concentrations of phthalate in their urine were more likely to die of heart disease than those with lesser exposure ... Similarly, Americans in this high-exposure group were more likely to die of any cause than those in low-exposure groups ... Our research suggests that the toll of this chemical on society is much greater than we first thought" - [Hill]

Is low-fat or whole-fat milk better for kids? Science says it makes no difference - Science Daily, 10/12/21 - "For the first time, researchers comprehensively measured the children's obesity, body composition, blood pressure, and blood biomarkers to monitor the effects of their dairy consumption ... Regardless of whether they were consuming whole fat or low-fat dairy, both groups of children took in similar amounts of calories ... Although children consuming low-fat dairy took in less calories and fat from dairy, they naturally turned to other foods and drinks to make up this difference ... Professor O'Sullivan said the findings showed no significant differences between the groups' obesity or cardiovascular health" -

Optimal blood pressure helps our brains age slower - Science Daily, 10/12/21 - "Normal blood pressure is defined by pressure below 120/80, whereas an optimal and healthier blood pressure is closer to 110/70 ... Compared to a person with a high blood pressure of 135/85, someone with an optimal reading of 110/70 was found to have a brain age that appears more than six months younger by the time they reach middle age"

Abstracts from this week:

The cost effectiveness of personalized dietary advice to increase protein intake in older adults with lower habitual protein intake: a randomized controlled trial - Eur J Nutr 2021 Oct 5;1-16 - "Dietary advice to increase protein intake to ≥ 1.2 g/kg aBW/d improved 400-m walk time and leg strength among older adults with a lower habitual protein intake. From a societal perspective, PROT was considered cost-effective compared to CON" - [Nutra USA] - See

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