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Home > Anti-aging Research > TMG

Trimethylglycine or Dimethylglycine

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News & Research:

  • Supplement treats schizophrenia in mice, restores healthy 'dance' and structure of neurons - Science Daily, 4/20/21 - "The supplement betaine was first isolated from sugar beets and is often associated with sweetness or umami flavor. Healthy levels of betaine come from both external food sources and internal synthesis in the body. Betaine supplements are already used clinically to treat the metabolic disease homocystinuria ... By protecting CRMP2 from damage, betaine treatment allows kif3b mutant neurons to build proper structures. With a structurally sound skeleton to navigate, the remaining functional KIF3B protein can shuttle cargo around the cell. Other test tube experiments revealed that KIF3B and CRMP2 can bind together, but their exact relationship remains unclear ... We know that the amount of betaine decreases in schizophrenia patients' brains, so this study strongly suggests betaine could be therapeutic for at least some kinds of schizophrenia" - See betaine anhydrous (TMG) at Amazon.com.
  • Boosting amino acid derivative may be a treatment for schizophrenia - Science Daily, 6/26/19 - "Betaine comes from a normal diet but is also synthesized in the body where it contributes to metabolism in various ways, including as an anti-inflammatory agent. Levels of betaine (glycine betaine or trimethylglycine) in the blood plasma of patients with schizophrenia has previously been found to be low, which suggested it is a possible therapeutic target ... In the new study, mice missing the Chdh gene, which is involved in making betaine, showed depressive behaviors and greatly reduced betaine levels in both the brain and blood. Betaine levels in the brain recovered when the it was given to the mice as a supplement in drinking water, demonstrating that betaine can pass through the blood-brain barrier" - See trimethylglycine at Amazon.com.
  • Legal Performance Enhancer Discovered in the Nutrient Betaine - Science Daily, 7/5/13 - "betaine -- a nutrient found in shellfish and beets -- boosts athletic performance by nearly six percent when added to a sports drink ... Betaine may contribute to creatine synthesis, which improves, strength, power and short-term performance ... researchers suggest: Dissolve 2.5 grams of betaine (either powder or tablet form) in a 20-ounce sports drink, and drink half in the morning and half in the afternoon"
  • Danisco extends betaine’s sport science - Nutra USA, 8/13/09 - "During various power, muscle endurance and anaerobic power exercise tests over a two week period, subjects given BetaPower showed a significant improvement in lower body muscle endurance and quality of the workout compared to those participants that were not given supplementation" - [Abstract]
  • Startling New Findings About Homocysteine - Life Extension Magazine, 11/03 - "a startling 100% of French elderly hospitalized patients showed higher than desired homocysteine levels, with 45% suffering from severe hyperhomocysteinemia ... Administration of vitamins B6 and B12, and folate, causes a significant decrease of elevated serum homocysteine concentrations in older persons ... More recent studies not only confirm the cardiovascular dangers of homocysteine, but also its toxic effect on the brain. It turns out that high blood levels of homocysteine increase the incidence of depression, memory impairment, and even Alzheimer’s disease"
  • The Benefits of CLA Too Good To Be True? - Life Extension Magazine, 6/99 - "TMG may be one of the most important nutrients to prevent heart disease, stroke, liver disease, slow aging and treat depression. TMG is also called glycine betaine, but the name "trimethylglycine" signifies that it has three methyl groups attached to each molecule of glycine. In the body, TMG donates one of its methyl groups to cellular DNA, which may help protect DNA against damage and its consequences, cancer and premature aging. When a TMG methyl group is donated to a molecule of homocysteine, it is converted first to methionine then to s-adenosyl-methionine (SAM). No "safe" level of homocysteine has been established, suggesting that taking nutrients like TMG could lower everyone's risk of heart attack and stroke, in addition to protecting DNA."
  • SAMe Needs The B's - Nutrition Science News, 7/00 - "users of this wonder pill should be aware that through the natural metabolism of SAMe, the amino acid homocysteine is created--a situation that can lead to artery damage and even heart disease. . . . .others have demonstrated that by simply upping one's intake of the vitamins B6, B12 and folic acid, this potential hazard can be avoided." (Note:  TMG is a precursor to SAM-e and lowers homocysteine instead of raising it.)
  • Diet, Supplements, Exercise and Sauna - Life Extension Magazine, 9/99 - "TMG, on the other hand, is very effective at raising the levels of SAMe and lowering homocysteine."
  • Dimethylglycine , dimethylglycine research, dimethylglycine benefits - Dr. Sahelian