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Anti-aging Research > Lactoferrin
Lactoferrin
Specific Recommendations:
News & Research:
Abstracts:
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Lactoferrin Attenuates
Intestinal Barrier Dysfunction and Inflammation By Modulating the MAPK Pathway
and Gut Microbes in Mice - J Nutr 2022 Sep 2 - "Deoxynivalenol
(DON) is a major mycotoxin present in staple foods (particularly in cereal
products), which induces intestinal inflammation and disrupts intestinal
integrity. Lactoferrin (LF) is a multifunctional protein that contributes to
maintaining intestinal homeostasis and improving host health. However, the
protective effects of LF on DON-induced intestinal dysfunction remain unclear
... Our study highlights a promising antimycotoxin approach of LF to alleviate
DON-induced intestinal dysfunction via modulating the mitogen-activated protein
kinase (MAPK) pathway and gut microbial community in mice" - See
lactoferrin at Amazon.com.
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Lactotransferrin promotes
intervertebral disc degeneration by regulating Fas and inhibiting human nucleus
pulposus cell apoptosis - Aging (Albany NY) 2022 May 25 -
"In recent years, intervertebral disc (IVD) degeneration
(IDD) has increased in age. There is still a lack of effective treatment in
clinics, which cannot improve the condition of IDD at the level of etiology ...
lactotransferrin (LTF) ... LTF promotes IDD progression by regulating Fas in
NPCs, and it may be an effective gene therapy target" - Note: An article
that easier to understand:
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Lactoferrin - Wikipedia - "Lactoferrin (LF),
also known as lactotransferrin (LTF), is a multifunctional protein of the
transferrin family. Lactoferrin is a globular glycoprotein with a molecular
mass of about 80 kDa that is widely represented in various secretory fluids,
such as milk, saliva, tears, and nasal secretions"
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Lactoferricin’s Role in Preventing Disc Degeneration - The
Rheumatologist, 9/16/13 - “We anticipate a positive
systemic impact that may prevent or decrease further joint deterioration,”
explained Hee-Jeong Im, PhD, corresponding author of the study. “The good
thing about lactoferrin/lactoferricin is that you can take it orally and you
don’t have to inject.”
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Lactoferrin modulates gut
microbiota and Toll-like receptors (TLRs) in mice with dysbiosis induced by
antibiotics - Food Funct 2022 May 1 - "Antibiotic
administration can result in gut microbiota and immune system alterations that
impact health. Bovine lactoferrin is a milk protein with anticancer,
anti-inflammatory, antimicrobial and immune modulatory activities ... In a
situation of intestinal dysbiosis induced by clindamycin, lactoferrin restores
the normal levels of some anti-inflammatory bacteria and TLRs and, therefore,
could be a good ingredient to be added to functional foods" - See
lactoferrin at Amazon.com.
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The effect of lactoferrin in
aging: role and potential - Food Funct 2021 Dec 20 -
"Aging is frequently accompanied by various types of physiological
deterioration, which increases the risk of human pathologies. Global public
health efforts to increase human lifespan have increasingly focused on lowering
the risk of aging-related diseases, such as diabetes, neurodegenerative
diseases, cardiovascular disease, and cancers. Dietary intervention is a
promising approach to maintaining human health during aging. Lactoferrin (LF) is
known for its physiologically pleiotropic properties. Anti-aging interventions
of LF have proven to be safe and effective for various pharmacological
activities, such as anti-oxidation, anti-cellular senescence, anti-inflammation,
and anti-carcinogenic. Moreover, LF has a pivotal role in modulating the major
signaling pathways that influence the longevity of organisms. Thus, LF is
expected to be able to attenuate the process of aging and greatly ameliorate its
effects" - See
lactoferrin at Amazon.com.
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Lactoferrin Alleviates Acute
Alcoholic Liver Injury by Improving Redox-Stress Response Capacity in Female
C57BL/6J Mice - J Agric Food Chem 2021 Dec 15 -
"Lactoferrin (Lf) can attenuate alcoholic liver injury (ALI) in male mice;
however, the effects of Lf on acute ALI in female mice are still unknown ...
low-dose Lf (LLf) and high-dose Lf (HLf) groups ... HLf could prevent acute ALI
in female mice" - See
lactoferrin at Amazon.com.
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Lactoferrin supplementation
for taste and smell abnormalities among patients receiving cancer chemotherapy
- Support Care Cancer 2021 Oct 13 - "Taste and smell
abnormalities (TSA) are common in patients receiving chemotherapy and may lead
to altered nutritional intake, treatment withdrawal, and impaired quality of
life. Lipid peroxidation in the oral cavity is one cause of TSA. Lactoferrin
(LFN), an iron-binding salivary protein, reduces production of lipid oxidation
byproducts and has been shown to reduce perception of unpleasant flavors ... A
total of 26 patients enrolled; 19 remained on study at day 30 and 17 at day 60.
Baseline mean TSQ scores were 6.5 (taste), 3.1 (smell), and 9.6 (composite). By
day 30, mean composite TSQ score improved by 1.7 (p = 0.018); taste and smell
improved by 0.6 (p = 0.062) and 1.1 (p = 0.042), respectively. From baseline to
day 60, mean composite TSQ score improved by 3.8 (p < 0.0001); taste and smell
improved by 1.9 (p = 0.001) and 1.8 (p = 0.003)" - See
lactoferrin at Amazon.com.
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Daily Dose of Bovine
Lactoferrin Prevents Ethanol-Induced Liver Injury and Death in Male Mice by
Regulating Hepatic Alcohol Metabolism and Modulating Gut Microbiota - Mol
Nutr Food Res 2021 Jul 30 - "Lactoferrin (Lf) possess a
protective potential to liver, but whether it can prevent alcoholic liver injury
(ALI) remains unclear ... LLf can ameliorate ALI, which is associated with the
regulation of hepatic alcohol metabolism and the modulation of gut microbiota.
However, excessive Lf intake may result in a diminished benefit" - See
lactoferrin at Amazon.com.
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Lactoferrin Is a Potential
Activator of the Vitamin D Receptor in Its Regulation of Osteogenic Activities
in C57BL/6J Mice and MC3T3-E1 Cells - J Nutr 2021 May 12 -
"Lactoferrin (LF) has been shown to promote bone
anabolism, and the vitamin D receptor (VDR) mediates the effects of vitamin D on
bone. We hypothesized that LF improves bone health by increasing VDR expression
... In vivo and in vitro, LF, a potential activator of VDR, promotes
osteogenesis. This suggests that dairy products, which are rich in LF, may serve
as a functional food to improve bone health"
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Lactoferrin for Mental
Health: Neuro-Redox Regulation and Neuroprotective Effects across the
Blood-Brain Barrier with Special Reference to Neuro-COVID-19 - J Diet Suppl
2021 May 12 - "Overall mental health depends in part on
the blood-brain barrier, which regulates nutrient transfer in-and-out of the
brain and its central nervous system. Lactoferrin, an innate metal-transport
protein, synthesized in the substantia nigra, particularly in dopaminergic
neurons and activated microglia is vital for brain physiology. Lactoferrin
rapidly crosses the blood-brain barrier via receptor-mediated transcytosis and
accumulates in the brain capillary endothelial cells. Lactoferrin receptors are
additionally present on glioma cells, brain micro-vessels, and neurons. As a
regulator of neuro-redox, microglial lactoferrin is critical for
protection/repair of neurons and healthy brain function. Iron imbalance and
oxidative stress are common among patients with neurodegenerative disorders such
as Parkinson's disease, Alzheimer's disease, dementia, depression, and multiple
sclerosis. As an endogenous iron-chelator, lactoferrin prevents iron
accumulation and dopamine depletion in Parkinson's disease patients. Oral
lactoferrin supplementation could modulate the p-Akt/PTEN pathway, reduce Aβ
deposition, and ameliorate cognitive decline in Alzheimer's disease ... Severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections are widely
reported in Parkinson's disease, Alzheimer's disease, dementia, and multiple
sclerosis patients with aggravated clinical outcomes. Lactoferrin, credited with
several neuroprotective benefits in the brain could serve as a potential
adjuvant in the clinical management of Neuro-COVID-19"
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Oral administration of
bovine lactoferrin accelerates the healing of fracture in ovariectomized rats
- J Bone Miner Metab. 2020 Apr 2 - "Three months after
bilateral ovariectomy, all rats underwent unilateral tibial osteotomy and were
then randomly divided into control group and bovine lactoferrin (bLF) group. At
4 and 8 weeks post-fracture, animals were sacrificed, and the fractured tibiae
and serum samples were collected for evaluation ... Our results showed that bLF
treatment not only accelerated the bone growth at an early stage of OPF healing
but also shortened the remolding process of OPF healing. When compared to
control group, bLF treatment induced a significant rise in callus BMD (by 35.0%
at 4 weeks and by 39.7% at 8 weeks; both p < 0.05) consistent with enhanced
biomechanical strength of the callus, with ultimate force increased by 3.39-fold
at 4 weeks (p < 0.05) and 1.95-fold at 8 weeks (p < 0.05). Besides, bLF
administration resulted in a substantial increase in serum levels of BALP and a
significant decrease in serum levels of TRAP 5b and TNF-α. Moreover, both the
RANKL/OPG mRNA ratio and the expression of TNF-α in the callus of bLF-treated
group were markedly lower than those in the control group" - See
bovine lactoferrin at Amazon.com and
bovine lactoferrin at iHerb.
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Dietary Lactoferrin
Supplementation Prevents Memory Impairment and Reduces Amyloid-β Generation in
J20 Mice - J Alzheimers Dis. 2020 Jan 24 - "Lactoferrin
(LF) is present in senile plaques and neurofibrillary tangles in the brains of
Alzheimer's disease (AD) patients and amyloid-β protein precursor transgenic
(AβPP-Tg) mice. LF has anti-inflammatory and antioxidant functions, which exert
neuroprotective effects against AD ... Nine-month-old J20 mice were fed with
control, 2% lactoferrin-containing (LF), and 0.5% pepsin-hydrolyzed lactoferrin-containing
(LF-hyd) diets for 3 months. We found that both the LF and LF-hyd diets
attenuated memory impairment in J20 mice and decreased brain Aβ 40 and Aβ 42
levels through the inhibition of amyloidogenic processing of AβPP, as it
decreased β-site amyloid protein precursor cleaving enzyme 1 (BACE1) levels.
Furthermore, we found for the first time that LF and LF-hyd treatments increased
both ApoE secretion and ATP-binding cassette A1 (ABCA1) protein levels in the
brains of J20 mice and in primary astrocyte cultures. Moreover, LF and LF-hyd
promoted extracellular degradation of Aβ in primary astrocyte cultures. These
findings indicate that the reduction in Aβ levels in the brains of mice fed with
both the LF and LF-hyd diets may also be mediated by increased ApoE secretion
and ABCA1 protein levels, which in turn leads to the enhanced degradation of Aβ
in the brains of J20 mice. Our findings suggest that LF and LF-hyd can be used
for the treatment and/or prevention of the development of AD" - See
lactoferrin at Amazon.com.
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Human trial
of liposomal lactoferrin supplementation for periodontal disease - Biol
Pharm Bull. 2010;33(10):1758-62 - "The PD was
significantly reduced by L-bLF supplementation, but the BOP and GCF volume were
not significantly changed. The MCP-1 level in GCF was significantly reduced,
while levels of other cytokines were not changed. Four-week L-bLF
supplementation also showed significant decreases of LPS-induced cytokine
production from PBMCs. Relative gene expressions of TLR2 and TLR4 did not
change. These results suggest that L-bLF supplementation can be effective in the
treatment of periodontal disease, although prospective controlled large-scale
studies are required"
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