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Anti-aging Research > lignans
Lignans
Specific Recommendations:
News & Research:
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Plant Polyphenols Lignans
and Cardiovascular Disease - Medscape, 10/12/21 -
"The evidence is building that there is an association between polyphenol intake
and chronic disease, especially for CVD. Plant polyphenols may be important
components of healthy plant-based diets that contribute to freedom from chronic
diseases such as CVD, diabetes, and possibly cancer and so are associated with a
reduction in all-cause mortality. However, although the associations are
promising, it would be helpful to have trial data, both for total and individual
polyphenols. At the same time, such trials would be difficult to undertake, and
sustained adherence may not be possible to achieve even over short periods of
time, as seen with the difficulty in increasing fruit and vegetable intake,[15]
let alone adherence over the number of years as required to see chronic disease
events. Perhaps an exception to this concern is the PREDIMED trial, in which
foods were provided that are considered highly desirable, as nuts and olive oil,
for the duration of the trial, and adherence was excellent."
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Plant compound reduces breast cancer mortality, study suggests - Science
Daily, 9/13/11 - "The most important type of
phytoestrogens in our Western diet are lignans, which are contained in
seeds, particularly flaxseeds, as well as in wheat and vegetables. In the
bowel, these substances are turned into enterolactone, which is absorbed by
the mucous tissue and which was determined by the Heidelberg researchers as
a biomarker in the patients' blood ... Compared to the study subjects with
the lowest enterolactone levels, the women with the highest blood levels of
this biomarker had an approximately 40 percent lower mortality risk ...
Another observation that may be interpreted in this direction is that Asian
women are less frequently affected by breast cancer. Their soy-rich diet
contains large amounts of another type of phytoestrogens, isoflavones. On
the other hand, scientists fear that isoflavones might imitate the
growth-promoting properties of real hormones and, thus, accelerate
hormone-dependent tumors such as breast cancer and prostate cancer. "It has
not yet been finally determined whether lignans in the body imitate the
hormone effect or, on the contrary, counteract it,""
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Lignans linked to healthier, thinner women: Study - Nutra USA, 2/6/09
- Enterolactone
restricts the proliferation of the LNCaP human prostate cancer cell line in
vitro - Mol Nutr Food Res. 2008 Apr 8;52(5):567-580 -
"The capacity of a pure mammalian lignan,
enterolactone (ENL) ... the antiproliferative activity of ENL is a
consequence of altered expression of cell cycle associated genes and
provides novel molecular evidence for the antiproliferative properties of a
pure lignan in prostate cancer"
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Dietary Lignans Improve Breast Cancer Survival - Medscape, 4/25/08 -
"a high intake of lignans was associated with about
a 50% reduction in mortality from all causes. This included cardiovascular
disease and other cancers"
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Norway spruce lignans cut hot flushes by 53 per cent - study - Nutra
USA, 11/12/07
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The growing science of lignans’ health benefits - Nutra USA, 8/1/06
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Strong evidence for lignans’ breast cancer protection - Nutra USA,
6/14/06 - "A high intake of plant lignans could
reduce the risk of breast cancer for pre-menopausal women by 78 per cent"
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A Natural Approach to Menopause
- Life Extension Magazine, 4/06 -
"For women approaching meno-pause, plant lignans
offer important protection against cancer, cognitive decline, and
hypertension ..."
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Study ‘confirms’ lignan dose for menopause supplements - Nutra USA,
3/27/06
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Lignans may protect against prostate cancer - Nutra USA, 3/8/06 -
"High intake of food items rich in phytoestrogens
(flaxseed, sunflower seeds, berries, peanuts, beans and soy) was associated
with a monotonically decreasing overall risk [26 per cent] of prostate
cancer"
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Lignans linked to better cognitive function - Nutra USA, 5/30/05
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Flax lignans: a cure for hair loss? - Nutra USA, 5/9/05 -
"Ten male sufferers of androgenetic alopecia aged
between 20- and 70- years received a 50mg daily dose of SDG in the form of
one 250 mg capsule of Acatris’ LinumLife Extra ... eight of the participants
reported a modest improvement in their hair loss condition, one reported a
great improvement and one reported no effect at all"
Abstracts:
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Lignan Intake and Risk of
Coronary Heart Disease J Am Coll Cardiol 2021 Aug 17 -
"Increased long-term intake of lignans was associated
with a significantly lower risk of total CHD in both men and women. Possible
synergistic effects may exist between lignan and fiber intake in relation to CHD
risk reduction, possibly through enhancing the production of enterolignans"
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Dietary Phytoestrogen Intake Is Associated with Reduced Colorectal Cancer
Risk - J Nutr. 2006 Dec;136(12):3046-3053 -
"Dietary lignan intake was associated with a significant reduction in
colorectal cancer risk [OR (T3 vs. T1) = 0.73; 95% CI: 0.56, 0.94], as was
isoflavone intake [OR (T3 vs. T1) = 0.71"
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