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Home > Health
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> Uric Acid
Uric Acid
Alternative News:
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Effects of Tart Cherry
Powder on Serum Uric Acid in Hyperuricemia Rat Model - Evid Based Complement
Alternat Med 2020 Jul 22 - "low dose of tart cherry
powder (0.17 g/kg·bw) showed effects on hyperuricemia by slightly decreasing
serum uric acid and improving kidney injury, whereas high dose of tart cherry
powder (0.50 g/kg·bw) could merely alleviate kidney injury. Meanwhile, adenosine
deaminase activity rather than xanthine oxidase activity was affected at low
dose, which reveals low dose of tarty cherry powder may be beneficial to
hyperuricemia through reduction of ADA activity, and its reported potentials on
antioxidation or anti-inflammation provide clues for further study" - See
tart cherry extract at Amazon.com and
iHerb.
- Folic acid
therapy reduces serum uric acid in hypertensive patients: a substudy of the
China Stroke Primary Prevention Trial (CSPPT) - Am J Clin Nutr. 2017 Feb
1 - "A total of 15,364 hypertensive patients were
randomly assigned to a double-blind daily treatment with a single tablet
that contained 10 mg enalapril and 0.8 mg folic acid (n = 7685) or 10 mg
enalapril alone (n = 7679) ... After a median of 4.4 y of treatment, the
mean ± SD UA concentration increased by 34.7 ± 72.5 μmol/L in the enalapril-alone
group and by 30.7 ± 71.8 μmol/L in the enalapril-folic acid group, which
resulted in a mean group difference of -4.0 μmol/L (95% CI: -6.5, -1.6
μmol/L; P = 0.001). Furthermore, compared with enalapril alone, enalapril-folic
acid treatment showed an increase in controlled hyperuricemia (30.3%
compared with 25.6%; OR: 1.31; 95% CI: 1.01, 1.70) and a decrease in
new-onset hyperuricemia (15.0% compared with 16.3%; OR: 0.89; 95% CI: 0.79,
0.99)" - See
folic acid products at Amazon.com
.
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Quercetin lowers plasma uric acid in pre-hyperuricaemic males: a randomised,
double-blinded, placebo-controlled, cross-over trial - Br J Nutr. 2016
Jan 20:1-7 - "The intervention included one tablet
containing 500 mg quercetin daily for 4 weeks, compared with placebo, with a
4-week washout period between treatments ... After quercetin treatment,
plasma uric acid concentrations were significantly lowered by -26·5 µmol/l
(95 % CI, -7·6, -45·5; P=0·008), without affecting fasting glucose, urinary
excretion of uric acid or blood pressure" - See
quercetin at Amazon.com
.
- Effect of Green Tea
Extract on Uric Acid and Urate Clearance - Medscape, 10/29/14 -
"Participants were assigned randomly at the
interventional period to consume GTE at 2 (GTE2), 4 (GTE4), or 6 (GTE6) g/d.
Levels of serum uric acid (SUA), uric acid clearance, and serum antioxidant
power (using trolox equivalent antioxidant capacity assay) were measured at
both ends of each study period ... Serum uric acid reduction was greatest in
GTE2 (from 4.81 ± 0.81 mg/dL to 4.64 ± 0.92 mg/dL, 3.53%). Uric acid
clearance decreased significantly in GTE2 (from 11.37 ± 6.41 mL/min per 1.73
m2 to 7.44 ± 2.74 mL/min per 1.73 m2, 34.56%, P < 0.05) and GTE4 (from 8.36
± 3.41 mL/min per 1.73 m2 to 5.78 ± 2.33 mL/min per 1.73 m2, 30.86%, P <
0.05). Serum antioxidant capacity (TEAC) increased significantly in GTE6
(from 32.77 ± 3.39 mg/mL to 35.41 ± 3.17 mg/mL, 8.06%, P < 0.05)" -
See
green tea extract at Amazon.com
.
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Polyphenols may reduce risk of gout: Study - Nutra USA, 12/13/10 -
"Gout is a painful form of arthritis caused by
disturbances in uric acid metabolism, when an overload of uric acid leads to
the formation of urate crystals in bodily tissues, especially the joints –
leading to recurring attacks of joint inflammation ... Hyperinsulinemia and
insulin resistance can lead to increased uric acid re-absorption in the
kidneys, which in turn can lead to a rise in serum uric acid concentration
... these results suggest that Oligonol lowers serum uric acid through
inhibition of xanthine oxidase, and may be effective for prevention and
treatment of hyperuricemia and/or gout" - See
oligonol at Amazon.com
.
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Vitamin C May Prevent Hyperuricemia, Gout - Medscape, 9/26/08 -
"Hyperuricemia is considered a precursor of gout,
which is the most common inflammatory arthritis in adult men ... An
association was observed between greater vitamin C intake and lower
prevalence of hyperuricemia defined as > 6 mg/dL. The multivariable odds
ratio for hyperuricemia for the highest intake of vitamin C (>1000 mg/d)
compared to the lowest (<90 mg/d) was 0.34 ... These findings support a
potential role of vitamin C in the prevention of hyperuricemia and gout"
- See
vitamin C products at Amazon.com
.
Other News:
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Uric Acid Associates With
Executive Function in Children and Adolescents With Hypertension -
Hypertension 2021 Mar 22 - "Observational studies show
that serum uric acid levels associate with cardiometabolic risk factors and
subclinical target organ damage. The aim of the present study is to investigate
the association of traditional cardiometabolic risk factors and uric acid with
the executive performance in children and adolescents. Ninety-nine children and
adolescents aged 5 to 18 years referred for assessment of primary hypertension
were include ... we found a positive association of serum uric acid with worse
executive performance in children at risk for primary hypertension. Extending
these cross-sectional findings with longitudinal studies may determine whether
high uric acid levels increases the risk of cognitive decline in youth"
-
Serum uric acid is
positively associated with the prevalence of nonalcoholic fatty liver in
non-obese type 2 diabetes patients in a Chinese population - J Diabetes
Complications 2021 Feb 16 - "SUA levels are strongly and
independently associated with the prevalence of NAFLD. SUA may be used as a
useful predictor to stratify the higher risks for NAFLD of non-obese type 2
diabetes patients"
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Sugar, Uric Acid, and
the Etiology of Diabetes and Obesity - Medscape, 10/21/13 -
"fructose-induced uric acid generation causes
mitochondrial oxidative stress that stimulates fat accumulation independent
of excessive caloric intake. These studies challenge the long-standing dogma
that "a calorie is just a calorie" and suggest that the metabolic effects of
food may matter as much as its energy content. The discovery that
fructose-mediated generation of uric acid may have a causal role in diabetes
and obesity provides new insights into pathogenesis and therapies for this
important disease"
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Serum
uric acid and metabolic risk - Curr Med Res Opin. 2013 Apr 24 -
"Key papers for inclusion were identified by a
PubMed search ... An elevated UA is both strongly associated and predictive
of the metabolic syndrome, and increasing evidence suggests that UA may have
a causal role. The classical viewpoint that UA is simply an innocuous marker
of metabolic syndrome that should not even be measured will likely have to
be modified. Lowering UA may be a novel treatment target for preventing
diabetes and justify prospective clinical trials on the possible benefits of
the measurement and lowering of serum UA on multiple chronic disease end
points"
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Uric
Acid Measurement Improves Prediction of Cardiovascular Mortality in Later
Life - J Am Geriatr Soc. 2013 Mar 15 - "In
individuals aged 70 and older without overt CVD, renal dysfunction, or
diuretic use, serum uric acid greater than 7.0 mg/dL was associated with
greater CVD mortality independent of classic CVD risk factors"
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Plasma
Uric Acid Is Associated with Increased Risk of Type 2 Diabetes Independent
of Diet and Metabolic Risk Factors - J Nutr. 2012 Nov 21 -
"case-cohort nested in the European Prospective
Investigation into Cancer and Nutrition-Netherlands study ... After
adjustment for established diabetes risk factors such as age, the HR
(highest vs. lowest quartile of uric acid) for diabetes was 4.36 (95% CI:
3.22, 5.90). Further adjustment for adiposity attenuated the HR to 1.86 (95%
CI: 1.32, 2.62). Additional adjustment for hypertension and biochemical
markers, such as TG, slightly attenuated the association [HR = 1.43 (95% CI:
0.97, 2.10)]. A uric acid-related dietary pattern did not confound the
association. In conclusion, this study supports that high uric acid
concentrations are associated with increased diabetes risk, although a large
part of the association can be explained by the degree of adiposity"
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Friend or Foe? Uric
Acid a 'Probable Cause' of CVD - Medscape, 4/30/12 -
"Using the electronic database of the HMO, Clalit,
starting in 2002, Leiba et al compared a historical cohort of healthy adults
(40–70 years) with low uric-acid levels (<3 mg/dL) with those who had normal
values (3.1–6.8 mg/dL) during 10 years of follow-up ... After 10 years of
follow-up, healthy subjects with normal uric-acid levels had a 53% higher
risk of developing hypertension (HR 1.53; p<0.001) compared with the
hypouricemic group ... the risks of developing new-onset diabetes and
chronic kidney disease were almost doubled (HR 1.84, p<0.001; and HR 1.93,
p=0.055, respectively) in the normal-uric-acid-level group compared with the
hypouricemic group ... "What do you do about it? I can't imagine putting
people with normal uric acid on allopurinol, so it comes back to the usual
kind of lifestyle advice.""
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Uric
acid may increase likelihood of severe osteoarthritis - Science Daily,
1/18/11 - "The researchers looked at 159 people, who
had knee osteoarthritis but no history of gout, a type of arthritis
triggered by uric acid crystals in the joints. The researchers found the
severity of osteoarthritis in their knees to be strongly correlated with the
amount of uric acid in their knees. The results, which are published online
in the Proceedings of the National Academy of Sciences, show, despite the
lack of gout history, above normal uric acid levels in 39 percent of the
study population, and evidence of the form of inflammation in the joints
that is typically triggered by uric acid crystals"
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Uric
acid level and allopurinol use as risk markers of mortality and morbidity in
systolic heart failure - Am Heart J. 2010 Nov;160(5):928-33 -
"The
allopurinol group
and highest uric acid quartile had the highest total mortality (41.7 and
42.4 per 100 person-years, respectively) and combined morbidity/mortality
(45.6 and 51.0 per 100 person-years, respectively). Allopurinol use and
highest uric acid quartile were independently associated with mortality
(hazard ratio [HR] 1.65, 95% CI 1.22-2.23, P = .001 and HR 1.35, 95% CI
1.07-1.72, P = .01, respectively) and combined morbidity/mortality (uric
acid quartile 4 vs 1: HR 1.32, 95% CI 1.06-1.66, P = .02; allopurinol use:
HR 1.48, 95% CI 1.11-1.99, P = .008) ... Elevated uric acid level was
independently associated with mortality in patients with severe systolic HF,
even when accounting for allopurinol use"
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Serum Uric Acid Linked With Development of Type 2 Diabetes - Science
Daily, 10/2/09 - "The pooled crude relative risk
(RR) of a 1 mg/dL increase in serum uric acid was 1.17"
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Gout Drug May Lower Blood Pressure - WebMD, 9/23/09 -
"A new study suggests a direct link between a
high-sugar diet and high blood pressure ... allopurinol could lower high
blood pressure by lowering uric acid" - Note: Kind of a confusing
article. Yeah, high blood sugar probably is a cause of high blood pressure
and high uric acid but the article implies that allopurinol lowers blood
pressure by lowering the uric acid not the blood sugar so why is it
discussing blood sugar? I've written WebMD before about articles like that
and they've agreed and changed it. This one is minor I guess.
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Healthy People With Elevated Levels Of Uric Acid Are At Risk Of Developing
Kidney Disease - Science Daily, 9/17/08 -
"Elevated uric acid levels in the blood indicate an increased risk of
new-onset kidney disease ... it may be appropriate to prescribe uric
acid–lowering drugs, such as allopurinol and probenecid, to these otherwise
healthy individuals ... individuals in the slightly elevated uric acid group
were 1.26 times as likely to develop kidney disease as those in the low uric
acid group. The odds of developing kidney disease among volunteers in the
elevated uric acid group were 1.63 times greater than that of individuals in
the low uric acid group"
-
High
Levels Of Uric Acid May Be Associated With High Blood Pressure - Science
Daily, 8/26/08 - "In the study, half of the 30
teen-agers with newly diagnosed high blood pressure and higher than normal
levels of uric acid in their blood underwent treatment with allopurinol
twice a day for four weeks. The other half received a placebo (an inactive
drug) on the same schedule. They then went without either drug for two weeks
before receiving the opposite treatment for another four weeks ... blood
pressures decreased to normal in 20 of the 30 teens when they were on
allopurinol. By contrast, only 1 of the 30 teens had normal blood pressure
when receiving placebo"
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