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Home > Health Conditions > Pancreatic Cancer

Pancreatic Cancer

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  • Agrimoniin is a dual inhibitor of AKT and ERK pathways that inhibit pancreatic cancer cell proliferation - Phytother Res 2023 May 8 - "Molecular-targeted therapy has shown its effectiveness in pancreatic cancer, while single-targeted drug often cannot provide long-term benefit because of drug resistance. Fortunately, multitarget combination therapy can reverse drug resistance and achieve better efficacy. The typical treatment characteristics of traditional Chinese medicine monomer on tumor are multiple targets, with small side effects, low toxicity, and so forth. Agrimoniin has been reported to be effective on some cancers, while the mechanism still needs to be clarified ... agrimoniin inhibited cell proliferation by simultaneously inhibiting AKT and ERK pathways. Moreover, agrimoniin could significantly increase the inhibitory effect of LY294002 and U0126 on pancreatic cancer cells. Meanwhile, in vivo experiments also supported the above results. In general, agrimoniin is a double-target inhibitor of AKT and ERK pathways in pancreatic cancer cells; it is expected to be used as a resistance reversal agent of targeted drugs or a synergistic drug of the inhibitor of AKT pathway or ERK pathway" - See agrimoniin at Amazon.com (I don't think they sell it).
    • The Therapeutic Effects of Agrimonia eupatoria L - NIH - "Agrimonia eupatoria L. is an herb of the Rosaceae family, widely used in traditional (folk) medicine for its beneficial effects. Its water extracts (infusions and decoctions) are used in the treatment of airway and urinary system diseases, digestive tract diseases, and chronic wounds"
  • Metformin inhibits neutrophil extracellular traps-promoted pancreatic carcinogenesis in obese mice - Cancer Lett 2023 Apr 6 - "Metformin and DNase I significantly reversed the pro-tumorigenic effects of obesity and NETs in vivo and in vitro" - See metformin at ReliableRX.
  • Study of Sirolimus in Patients With Advanced Pancreatic Cancer - clinicaltrials.gov, 9/7/18 - "In preclinical studies, investigators found that rapamycin can effectively inhibit the angiogenesis of liver Cancer led by tumor-associated macrophages (TAM), thereby inhibiting the progression of liver Cancer.In vitro experiments on pancreatic cancer showed that rapamycin can directly inhibit the proliferation of pancreatic cancer cells.After the treatment with rapamycin in the homologous xenograft tumor model of mice, it was found that the tumor growth of mice was significantly inhibited. Further analysis suggested that rapamycin not only directly inhibits tumor proliferation, but also reverses the immune suppressive microenvironment of pancreatic cancer and promotes the T-cell-mediated anti-tumor immune response.Preclinical findings suggest that rapamycin may benefit survival in pancreatic cancer patients, which makes us very interested in the efficacy of rapamycin in patients with advanced pancreatic cancer" - See Siromus (rapamycin) at ReliableRXPharmacy.
  • Pancreatic enzyme supplementation versus placebo for improvement of gastrointestinal symptoms in non-responsive celiac disease: A cross-over randomized controlled trial - Front Med (Lausanne) 2023 Jan 4 - "Pancreatic Exocrine Insufficiency (PEI) is a possible cause of recurrent/persistent symptoms in celiac disease. Although pancreatic enzyme supplementation may be used to treat non-responsive celiac disease (NRCD) in clinical practice, clinical outcomes are variable and there is limited and low quality evidence to support this practice. The aim of this study was to assess the efficacy of pancreatic enzyme supplements (PES) for improvement of gastrointestinal symptoms in NRCD ... In this prospective, cross-over randomized, placebo-controlled study, PES did not improve symptoms in patients with NRCD. It is unclear whether this is a trial effect or related to administration of omeprazole."
  • Survival Benefit of Metformin Adjuvant Treatment For Pancreatic Cancer Patients: a Systematic Review and Meta-Analysis - Cell Physiol Biochem 2018;49:837–847 - "The current systematic review and meta-analysis based on 17 studies involving 36791 patients suggests that pancreatic cancer patients with metformin adjuvant treatment may have a prolonged survival compared with those not receiving metformin, though there is evidence of moderate heterogeneity across studies" - See metformin at ReliableRX..
  • Celastrol Modulates Multiple Signaling Pathways to Inhibit Proliferation of Pancreatic Cancer via DDIT3 and ATF3 Up-Regulation and RRM2 and MCM4 Down-Regulation - Onco Targets Ther. 2021 - "Celastrol, a quinone methide triterpenoid, is a natural product extracted from Tripterygium wilfordii Hook F. (“Thunder of God Vine”) plant and is used widely in TCM (traditional Chinese medications). The biological activities of celastrol have been extensively explored; it has been documented that celastrol has anticancer activity against various tumors, including leukemia, melanoma glioma, and prostate cancer.19–28 The celastrol anticancer activity was owed to its capability to compromise different cellular mechanisms in cancer cells. Celastrol is found to suppress tumor necrotic factor (TNF) induced cancer cells metastasis, nuclear factor (NF)-kB signaling, heat shock protein (HSP) 90, extracellular signal-regulated kinase (ERK), proteasome, and modulates TRAIL-induced apoptosis ... Celastrol inhibited pancreatic cancer proliferation through affecting several signaling pathways. The celastrol’s inhibitory effects on pancreatic cancer was basically attributed to DDIT3 and ATF3 activation and suppression of RRM2 and MCM4 genes" - See Thunder of God Vine at Amazon.com.
  • THE RELATIONSHIP BETWEEN DIABETES MELLITUS AND PANCREATIC CANCER - DIABETES MELLITUS AS A RED FLAG FOR PANCREATIC CANCER - Cancer Epidemiol Biomarkers Prev 2023 Jan 3 - "The relationship between diabetes mellitus (DM) and pancreatic cancer is complex- DM is both a risk factor and early sign of pancreatic cancer. DM is a risk factor for pancreatic cancer because it increases insulin resistance, intrapancreatic concentrations of insulin, and the bioavailability of IGF, subsequently promoting ductal cell proliferation. Accordingly, treatment targeting the insulin/IGF pathway is the focus of many researchers. Antidiabetic drugs modify the risk for pancreatic cancer- metformin's antineoplastic effect being most notable and indicating potential clinical use in pancreatic cancer. New-onset DM can also be the first manifestation of pancreatic cancer. There are several theories for the pathogenesis of DM in pancreatic cancer, the most important being that DM is a paraneoplastic syndrome caused by diabetogenic factors. As a consequence of this intricate relationship, new-onset DM after the age of 50 is considered a red flag for pancreatic cancer, prompting the need for screening in this patient population. Multiple clinical studies are currently underway exploring this matter. A better understanding of the relationship between DM and pancreatic cancer could aid in developing novel screening and treatment strategies for pancreatic cancer. This could ultimately improve the prognosis and quality of life of patients with pancreatic cancer"
  • Dapagliflozin improves pancreatic islet function by attenuating microvascular endothelial dysfunction in type 2 diabetes - Diabetes Metab Res Rev 2022 Dec 24 - "Sodium-glucose co-transporter type 2 (SGLT2) inhibitors, including dapagliflozin, improve β cell function in type 2 diabetic individuals. Whether dapagliflozin can protect islet microvascular endothelial cells (IMECs) and thus contribute to the improvement of β cell function remains unknown ... Dapagliflozin restores islet vascularization and attenuates the inflammation of IMECs in type 2 diabetic mice. The dapagliflozin-induced improvement of β cell function is at least partially accounted for by its beneficial effects on IMECs in a PI3K/Akt-mTOR-dependent manner" - See dapagliflozin at reliablerxpharmacy.com.
  • Impact of cumulative hyperglycemic burden on the pancreatic cancer risk: A nationwide cohort study - Diabetes Res Clin Pract 2022 Dec 10 - "We aimed to investigate how much cumulative hyperglycemia exposure increases pancreatic cancer risk. ... The pancreatic cancer incidence increased significantly according to the hyperglycemic burden, defined as sustained hyperglycemic exposure, including pre-diabetic levels"
  • Association between alcohol consumption and risk of pancreatic cancer: The Japan Public Health Center-based Prospective Study - Cancer Epidemiol Biomarkers Prev 2022 Sep 3 - "When the population was limited to men whose alcohol drinking habit remained unchanged from the baseline survey to the 5-year follow-up survey, a significant association was observed in drinkers with alcohol consumption of 1-299 g/week compared with non/occasional drinkers (multivariable-adjusted HR: 1.73"
  • Molecular Mechanism of Curcumin and Its Analogs as Multifunctional Compounds against Pancreatic Cancer - Nutr Cancer 2022 May 18 - "Research evidence suggests that curcumin can influence PC development through multiple molecular mechanisms. The synthesis of novel curcumin analogs and preparation of curcumin nano-formulations are effective strategies to overcome the low bioavailability of curcumin in the treatment of PC. This review aims to summarize the mechanisms of action of curcumin in preclinical and clinical studies on PC and research progress in enhancing its bioavailability" - See curcumin at Amazon.com.
  • Dietary Vitamin K Intake and the Risk of Pancreatic Cancer: A Prospective Study of 101,695 American Adults - Am J Epidemiol 2021 Oct 1 - "dietary intakes of phylloquinone (for quartile 4 vs. quartile 1, hazard ratio (HR) = 0.57, 95% confidence interval (CI): 0.39, 0.83; P for trend = 0.002) and dihydrophylloquinone (for quartile 4 vs. quartile 1, HR = 0.59; 95% CI: 0.41, 0.85; P for trend = 0.006), but not menaquinones (for quartile 4 vs. quartile 1, HR = 0.93 ... dietary intakes of phylloquinone and dihydrophylloquinone, but not menaquinones, confer a lower risk of pancreatic cancer" - See vitamin K at Amazon.com and vitamin K at iHerb.com.
  • Randomized Phase II Study of Gemcitabine Monotherapy vs. Gemcitabine with an EPA-Enriched Oral Supplement in Advanced Pancreatic Cancer - Nutr Cancer 2021 Jan 13 - "Pancreatic cancer is often associated with cachexia. It had been reported that eicosapentaenoic acid (EPA) improve cachexia. This study aimed to evaluate the efficacy and safety of gemcitabine with an EPA-enriched oral supplement in patients with advanced pancreatic cancer ... The 1-year survival probability of the EPA group was 35% while the gemcitabine group was 19%. The median survival times were 8.2 and 9.7 mo, respectively. The hazard ratio for EPA group was 0.79 [95% CI 0.46-1.37]; (P = 0.40). The toxicities were mild and insignificant in both groups. More beneficial effects of EPA in survival were observed in men, pancreatic body-tail and low C-reactive protein patients" - See omega-3 supplements at Amazon.com.
  • Poultry and Fish Intake and Pancreatic Cancer Risk: A Systematic Review and Meta-Analysis - Nutr Cancer 2021 Jan 12 - "The pooled RR of PC for the highest vs. lowest poultry intake category was 1.14 (95% CI: 1.02-1.26) in cohort studies. There was no appreciable link between fish intake and PC risk (RR: 1.00, 95% CI: 0.93-1.07). Our results suggest that large amount of poultry intake may increase PC risk, while fish intake is unlikely to be linked to PC risk"
  • Whole-Grain Intake and Pancreatic Cancer Risk-The Danish, Diet, Cancer and Health Cohort - J Nutr 2021 Feb 9 - "Total whole-grain product intake was associated with a 7% lower incidence of pancreatic cancer per serving (50 g/d) (HR: 0.93; 95% CI: 0.86, 1.00), and in the sex-specific analyses, an inverse association was found only in men ... Our findings indicate that intake of whole grains is associated with lower risk of pancreatic cancer in middle-aged men. Consuming ample amounts of whole grains may prove beneficial in terms of lowering pancreatic cancer risk"
  • Vitamin B6, vitamin B12 and methionine and risk of pancreatic cancer: a meta-analysis - Nutr J 2020 Oct 4 - "Our study suggests that high intake of vitamin B6 and high concentration of blood PLP levels may be protective against the development of pancreatic cancer" - See vitamin B6 at Amazon.com.
  • A Chirality-Dependent Action of Vitamin C in Suppressing KRAS Mutant Tumor Growth by the Oxidative Combination: Rationale for Cancer Therapeutics - Int J Cancer. 2019 Aug 31 - "Kirsten rat sarcoma (KRAS) mutant cancers, which constitute the vast majority of pancreatic tumors, are characterized by their resistance to established therapies and high mortality rates ... our results demonstrate that the oxidizing combination of arsenic trioxide and D-VC is a promising approach for the treatment of KRAS mutant human cancers" - See vitamin C products at Amazon.com.
  • Vitamin B6 Intake and Pancreatic Carcinoma Risk: A Meta-Analysis - Nutr Cancer. 2019 Jun 21:1-6 - "This meta-analysis suggested that vitamin B6 intake could significantly decrease pancreatic carcinoma risk" - See vitamin B6 at Amazon.com.
  • Oral bacteria in pancreas linked to more aggressive tumors - Science Daily, 3/14/19 - "We were surprised to find oral bacteria in the pancreas, but it wasn't totally unexpected ... The bacteria we identified has already been shown in an earlier, smaller study to be higher in the saliva of patients with pancreatic cancer ... maybe we can reduce the risk of transferring oral bacteria to the pancreas by rinsing the mouth with an antibacterial agent and ensuring good oral hygiene prior to examination"
  • Serum B6 vitamers (pyridoxal 5'-phosphate, pyridoxal, and 4-pyridoxic acid) and pancreatic cancer risk: two nested case-control studies in Asian populations - Cancer Causes Control. 2016 Nov 9 - "high serum PLP was associated with a reduced risk of pancreatic cancer (P for trend = 0.048); the adjusted odds ratio for the highest category of PLP (>52.4 nmol/L) was 0.46 (95% CI 0.23, 0.92) compared to vitamin B6 deficiency (<20 nmol/L) ... Higher concentrations of PLP may protect against the development of pancreatic cancer. The protective effect may be more apparent in populations with low concentrations of circulating vitamin B6" - Note: B6 also helps the body to make melatonin and my be helpful in Alzheimer's disease.  I take 25 mg with 1 mg of melatonin every night.  See Best Naturals Vitamin B-6 25 mg 250 Tablets at Amazon.com.
  • Curcumin AntiCancer Studies in Pancreatic Cancer - Nutrients. 2016 Jul 16;8(7) - "Several preclinical studies have demonstrated that curcumin, a naturally occurring polyphenolic compound, has anticancer effects against different types of cancer, including PC, by modulating many molecular targets. Regarding PC, in vitro studies have shown potent cytotoxic effects of curcumin on different PC cell lines including MiaPaCa-2, Panc-1, AsPC-1, and BxPC-3. In addition, in vivo studies on PC models have shown that the anti-proliferative effects of curcumin are caused by the inhibition of oxidative stress and angiogenesis and are due to the induction of apoptosis" - See curcumin products at Amazon.com.
  • Association between intake of antioxidants and pancreatic cancer risk: a meta-analysis - Int J Food Sci Nutr. 2016 Jun 30 - "Comparing the highest with lowest categories, higher dietary intakes of selenium, vitamin C, vitamin E, β-carotene and β-cryptoxanthin were significantly associated with reduced pancreatic cancer risk (for selenium, pooled OR = 0.47, 95%CI 0.26-0.85; for vitamin C, pooled OR = 0.68, 95%CI 0.57-0.80; for vitamin E, pooled OR = 0.70, 95%CI 0.62-0.81; for β-carotene, pooled OR = 0.74, 95%CI 0.56-0.98; for β-cryptoxanthin, pooled OR = 0.70, 95%CI 0.56-0.88). Lycopene intake was marginally associated with pancreatic cancer risk (pooled OR = 0.85, 95%CI 0.73-1.00), while no significant association was observed for α-carotene, lutein and zeaxanthin"
  • How diabetes drug metformin inhibits progression of pancreatic cancer - Science Daily, 1/14/16 - "metformin decreases the inflammation and fibrosis characteristic of the most common form of pancreatic cancer ... Diabetic patients taking metformin -- a commonly used generic medication for type 2 diabetes -- are known to have a reduced risk of developing pancreatic cancer; and among patients who develop the tumor, those taking the drug may have a reduced risk of death" - See metformin at The Antiaging Store.
  • Magnesium intake may be beneficial in preventing pancreatic cancer - Science Daily, 12/18/15 - "The study found that every 100-milligrams-per-day decrease in magnesium intake was associated with a 24 percent increase in the occurrence of pancreatic cancer. The study also found that the effects of magnesium on pancreatic cancer did not appear to be modified by age, gender, body mass index or non-steroidal anti-inflammatory drug use, but was limited to those taking magnesium supplements either from a multivitamin or individual supplement ... For those at a higher risk of pancreatic cancer, adding a magnesium supplement to their diet may prove beneficial in preventing this disease" - See Jarrow Formulas, MagMind at Amazon.com.
  • Fish, n-3 PUFA consumption, and pancreatic cancer risk in Japanese: a large, population-based, prospective cohort study - Am J Clin Nutr. 2015 Nov 4 - "we found an inverse association of marine n-3 PUFA (EPA+DPA+DHA) and DHA consumption with pancreatic cancer risk: compared with the lowest quartile, multivariate-adjusted HRs in the highest quartile were 0.70 (95% CI: 0.51, 0.95; P-trend = 0.07) and 0.69 (0.51, 0.94; P-trend = 0.03), respectively" - See fish oil supplements at Amazon.com.
  • Vitamin E Intake and Pancreatic Cancer Risk: A Meta-Analysis of Observational Studies - Med Sci Monit. 2015 May 1;21:1249-1255 - "In total, 10 observational studies (6 case-control studies and 4 cohort studies) were included. The overall RR (95% CI) of pancreatic cancer for the highest vs. the lowest level of vitamin E intake was 0.81" - See Jarrow FamilE (contains all eight members of the vitamin E family, includes Tocomin) at Amazon.com.
  • The Consumption of Omega-3 Polyunsaturated Fatty Acids Improves Clinical Outcomes and Prognosis in Pancreatic Cancer Patients: A Systematic Evaluation - Nutr Cancer. 2014 Nov 25:1-7 - "Eleven trials met our inclusion criteria. There was a significant increase in body weight [weighted mean difference (WMD) = 0.62; 95% confidence interval (CI), 0.54-0.69, P < 0.00001) and lean body mass (WMD = 0.96; 95% CI, 0.86-1.06, P < 0.00001), a significant decrease in resting energy expenditure (WMD = -29.74; 95% CI, -55.89-3.59, P = 0.03), and an increase in overall survival (130-259 days vs. 63-130 days) in unresectable pancreatic cancer patients who consumed an oral nutrition supplement enriched with n-3 PUFAs compared to those who consumed conventional nutrition" - See fish oil supplements at Amazon.com.
  • Green tea could reduce pancreatic cancer risk: Study explains how - Science Daily, 5/30/14 - "EGCG, the active biologic constituent in green tea, changed the metabolism of pancreatic cancer cells by suppressing the expression of an enzyme associated with cancer, LDHA" - See green tea extract at Amazon.com.
  • Metformin is associated with reduced risk of pancreatic cancer in patients with type 2 diabetes mellitus: A systematic review and meta-analysis - Diabetes Res Clin Pract. 2014 Apr 18 - "Use of metformin was associated with a significant lower risk of pancreatic cancer [RR 0.63" - See metformin at The Antiaging Store.
  • Fatty acids found in dairy, protein and unsaturated fatty acids are associated with risk of pancreatic cancer in a case-control study - Int J Cancer. 2014 Apr 15;134(8):1935-46 - "Significant inverse association (trend p-value < 0.05) between pancreatic cancer and the groupings (highest vs. lowest consumption quintile OR [95% CI]) was as follows: meat replacement (0.67 [0.43-1.02]), total protein (0.58 [0.39-0.86]), vitamin B12 (0.67 [0.44, 1.01]), zinc (0.48 [0.32, 0.71]), phosphorus (0.62 [0.41, 0.93]), vitamin E (0.51 [0.33, 0.78]), polyunsaturated FAs (0.64 [0.42, 0.98]) and linoleic acid (FA 18:2) (0.62 [0.40-0.95]). Increased risk associations were observed for saturated FAs (1.48 [0.97-2.23]), butyric acid (FA 4:0) (1.77 [1.19-2.64]), caproic acid (FA 6:0) (2.15 [1.42-3.27]), caprylic acid (FA 8:0) (1.87 [1.27-2.76]) and capric acid (FA 10:0) (1.83 [1.23-2.74])"
  • Gallic Acid Is an Active Component for the Anticarcinogenic Action of Grape Seed Procyanidins in Pancreatic Cancer Cells - Nutr Cancer. 2013 Dec 10 - "GSPE inhibits cell proliferation and increases apoptosis in MIA PaCa-2 cells, which is primarily mediated by the downregulation of the antiapoptotic protein Bcl-2 and the depolarization of the mitochondrial membrane. GSPE also reduced the formation of reactive oxygen species. The component of the extract that possesses the highest antiproliferative and proapoptotic activity was gallic acid" - See grape seed extract at Amazon.com.
  • Healthy Eating and Risk for Pancreatic Cancer - Medscape, 10/4/13 - "We calculated the HEI-2005 score for 537 218 men and women in the National Institutes of Health–American Association of Retired Persons Diet and Health Study using responses to food frequency questionnaires returned in 1995 and 1996 ... We identified 2383 incident, exocrine pancreatic cancer cases (median = 10.5 years follow-up). Comparing participants who met the most dietary guidelines (Q5) with those who met the fewest guidelines (Q1), we observed a reduced risk of pancreatic cancer (HR = 0.85, 95% CI = 0.74 to 0.97). Among men there was an interaction by body mass index (P interaction = .03), with a hazard ratio of 0.72 (95% CI = 0.59 to 0.88) comparing Q5 vs Q1 in overweight/obese men (body mass index ≥25kg/m2) but no association among normal weight men"
  • Vitamin E δ-tocotrienol prolongs survival in the LSL-KrasG12D/+;LSL-Trp53R172H/+;Pdx-1-Cre (KPC) transgenic mouse model of pancreatic cancer - Cancer Prev Res (Phila). 2013 Aug 20 - "Previous work has shown that vitamin E δ-tocotrienol (VEDT) prolongs survival and delays progression of pancreatic cancer in the LSL-KrasG12D/+;Pdx-1-Cre mouse model of pancreatic cancer ... KPC mice were randomized into 4 groups: 1) vehicle (olive oil, 1.0 mL/kg PO twice/day and PBS 1.0 mL/kg IP twice/week), 2) gemcitabine (100 mg/kg IP twice/week), 3) VEDT (200 mg/kg PO twice/day), and 4) gemcitabine + VEDT ... At 16 weeks, survival was 10% in the vehicle group, 30% in the gemcitabine group, 70% in the VEDT group (P<0.01), and 90% in the VEDT combined with gemcitabine group (P<0.05). VEDT alone and combined with gemcitabine resulted in reversal of epithelial-to-mesenchymal transition in tumors --- These results strongly support further investigation of VEDT alone and in combination with gemcitabine for pancreatic cancer prevention and treatment" - See Jarrow FamilE (contains all eight members of the vitamin E family, includes Tocomin) at Amazon.com.
  • Celery, artichokes contain flavonoids that kill human pancreatic cancer cells - Science Daily, 8/15/13 - "Apigenin alone induced cell death in two aggressive human pancreatic cancer cell lines. But we received the best results when we pre-treated cancer cells with apigenin for 24 hours, then applied the chemotherapeutic drug gemcitabine for 36 hours ... our study indicated that taking antioxidant supplements on the same day as chemotherapeutic drugs may negate the effect of those drugs ... One of the ways that chemotherapeutic drugs kill cells is based on their pro-oxidant activity, meaning that flavonoids and chemotherapeutic drugs may compete with each other when they're introduced at the same time ... In one of the cancer cell lines, the percentage of cells undergoing apoptosis went from 8.4 percent in cells that had not been treated with the flavonoid to 43.8 percent in cells that had been treated with a 50-micromolar dose. In this case, no chemotherapy drug had been added" - See Garden of Life, Radical Fruits Antioxidant Complex at Amazon.com.
  • Healthy Eating Might Ward Off Pancreatic Cancer - WebMD, 8/15/13 - "it is important to focus on eating an overall healthful diet and not on a single nutrient, supplement or specific food in hopes of preventing cancer or any other disease ... The effect of eating a variety of fruits, vegetables and whole grains, and limiting sugar, unhealthy fats and alcohol, is greater than the sum of its parts when it comes to lowering the risk of chronic disease ... Arem's group assessed the eating habits of more than 500,000 people, aged 50 to 71, who took part in the U.S. National Institutes of Health/AARP Diet and Health Study ... those who followed the diet lowered their chances of pancreatic cancer by 15 percent, compared with those who didn't"
  • Flavonoid apigenin modified gene expression associated with inflammation and cancer and induced apoptosis in human pancreatic cancer cells through inhibition of GSK-3β/NF-κB signaling cascade - Mol Nutr Food Res. 2013 Aug 14 - "Flavonoids have a protective role in pancreatic cancer tumorigenesis" - See Garden of Life, Radical Fruits Antioxidant Complex at Amazon.com.
  • Bitter melon juice prevents pancreatic cancer in mouse models - Science Daily, 3/12/13 - "Three years ago researchers showed the effect of bitter melon extract on breast cancer cells only in a Petri dish. This study goes much, much farther. We used the juice -- people especially in Asian countries are already consuming it in quantity. We show that it affects the glucose metabolism pathway to restrict energy and kill pancreatic cancer cells" - See bitter melon at Amazon.com.
  • In vitro and in vivo anticancer efficacy of silibinin against human pancreatic cancer BxPC-3 and PANC-1 cells - Cancer Lett. 2012 Sep 26 - "Silibinin suppresses the growth of many cancers; however, its efficacy against pancreatic cancer has not been evaluated in established preclinical models. Here, we investigated in vitro and in vivo effects of silibinin against lower and advanced stages of human pancreatic carcinoma cells ... Overall, these findings show both in vitro as well as in vivo anticancer efficacy of silibinin against pancreatic cancer that could involve inhibition of cell proliferation, cell cycle arrest, apoptosis induction and/or decrease in tumor angiogenesis" - See silymarin at Amazon.com.
  • L-Carnitine-supplementation in advanced pancreatic cancer (CARPAN) - a randomized multicentre trial - Nutr J. 2012 Jul 23;11(1):52 - "Cachexia, a >10% loss of body-weight, is one factor determining the poor prognosis of pancreatic cancer. Deficiency of L-Carnitine has been proposed to cause cancer cachexia ... While these data are preliminary and need confirmation they indicate that patients with pancreatic cancer may have a clinically relevant benefit from the inexpensive oral supplementation of L-Carnitine" - See l-carnitine at Amazon.com.
  • High dietary antioxidant intake might cut pancreatic cancer risk - Science Daily, 7/23/12 - "Increasing dietary intake of the antioxidant vitamins C, E, and selenium could help cut the risk of developing pancreatic cancer by up to two thirds ... weekly intake of selenium in the top 25% of consumption roughly halved their risk of developing pancreatic cancer compared with those whose intake was in the bottom 25% ... those whose vitamins C, E, and selenium intake was in the top 25% of consumption were 67% less likely to develop pancreatic cancer than those who were in the bottom 25%"
  • Fiber may boost pancreatic health: Study - Nutra USA, 1/25/12 - "The greatest intakes of soluble fiber were linked to a 60% reduction in pancreatic cancer risk, while insoluble fiber intake was linked to a 50% reduction in risk" - [Abstract] - See Jarrow Formulas, Fiber Perfect, 150 Veggie Caps at iHerb.
  • COFFEE, TEA AND SUGAR-SWEETENED CARBONATED SOFT DRINK INTAKE AND PANCREATIC CANCER RISK: A POOLED ANALYSIS OF 14 COHORT STUDIES - Cancer Epidemiol Biomarkers Prev. 2011 Dec 22 - "Sugar-sweetened carbonated soft drink (abbreviated as SSB) intake has been associated with higher circulating levels of insulin, which may promote carcinogenesis. Few prospective studies have examined SSB intake and pancreatic cancer risk; results have been heterogeneous ... pooled analysis from 14 prospective cohort studies ... No statistically significant associations were observed between pancreatic cancer risk and intake of coffee (MVRR=1.10, 95% CI=0.81-1.48 comparing >900 to <0g/day; 237g≈8oz), tea (MVRR=0.96, 95% CI=0.78-1.16 comparing >400 to 0g/day; 237g≈8oz) or SSB (MVRR=1.19, 95% CI=0.98-1.46 comparing >250 to 0g/day; 355g≈12oz) (p-value, test for between-studies heterogeneity >0.05). These associations were consistent across levels of sex, smoking status and body mass index. When modeled as a continuous variable, a positive association was evident for SSB (MVRR=1.06, 95% CI=1.02-1.12)"
  • Vitamin D may slash pancreatic cancer risk: Harvard study - Nutra USA, 12/14/11 - "Data from over 1,500 people collected over 14 years indicated that people with vitamin D insufficiency were at a 30% increased risk of developing pancreatic cancer, compared with people with adequate levels of the sunshine vitamin ... Pancreatic cancer is the fourth leading causing of cancer death (about 37,500 per year) in the US" - [Abstract] - See vitamin D at Amazon.com.
  • Plasma 25-Hydroxyvitamin D and Risk of Pancreatic Cancer - Cancer Epidemiol Biomarkers Prev. 2011 Nov 15 - "Mean plasma 25(OH)D was lower in cases versus controls (61.3 vs. 64.5 nmol/L, P=0.005). In logistic regression models, plasma 25(OH)D was inversely associated with odds of pancreatic cancer. Participants in quintiles two through five had multivariable-adjusted odds ratios (OR [95% confidence intervals]) of 0.79 (0.56-1.10), 0.75 (0.53-1.06), 0.68 (0.48-0.97), and 0.67 (0.46-0.97); P-trend=0.03), respectively, compared to the bottom quintile. Compared to those with insufficient levels (25[OH]D<50 nmol/L), ORs were 0.75 (0.58-0.98) for subjects with relative insufficiency (25[OH]D 50-<75 nmol/L) and 0.71 (0.52-0.97) for those with sufficient levels (25[OH]D≥75 nmol/L). No increased risk was noted in subjects with 25(OH)D ≥100 nmol/L, as suggested in a prior study. In subgroup analyses, ORs for the top versus bottom quartile of 25(OH)D were 0.72 (0.48-1.08) for women, 0.73 (0.40-1.31) for men, and 0.73 (0.51-1.03) for Whites ... Low circulating 25(OH)D may predispose individuals to the development of pancreatic cancer" - See vitamin D at Amazon.com.
  • Physical activity, energy restriction, and the risk of pancreatic cancer: a prospective study in the Netherlands - Am J Clin Nutr. 2011 Sep 28 - "For past sports activities, we observed a significantly decreased risk of pancreatic cancer (HR: 0.80; 95% CI: 0.64, 0.99). Proxies for energy restriction were not related to pancreatic cancer risk. When the results for energy restriction were stratified by height, a significant multiplicative interaction was observed for the Economic Depression period (P = 0.002). Shorter individuals (height less than the sex-specific median adult height) with an unemployed father during the Economic Depression period had a significantly lower cancer risk (HR: 0.31; 95% CI: 0.14, 0.66) than did taller individuals with an employed father. No significant interactions were observed for exposure to energy restriction during the World War II years and the Hunger winter"
  • Zyflamend suppresses growth and sensitizes human pancreatic tumors to gemcitabine in an orthotopic mouse model through modulation of multiple targets - Int J Cancer. 2011 Sep 20. doi: 10.1002/ijc.26442 - "Zyflamend inhibited the proliferation of pancreatic cancer cell lines regardless of p53 status and also enhanced gemcitabine-induced apoptosis. This finding correlated with inhibition of NF-kB activation by Zyflamend and suppression of cyclin D1, c-myc, COX-2, Bcl-2, IAP, survivin, VEGF, ICAM-1, and CXCR4. In nude mice, oral administration of Zyflamend alone significantly inhibited the growth of orthotopically transplanted human pancreatic tumors, and when combined with gemcitabine, further enhanced the antitumor effects. Immunohistochemical and Western blot analyses of tumor tissue showed that the suppression of pancreatic cancer growth correlated with inhibition of proliferation index marker (Ki-67), COX-2, MMP-9, NF-kB, and VEGF. Overall, these results suggest that the concentrated multiherb product Zyflamend alone can inhibit the growth of human pancreatic tumors and, in addition, can sensitize pancreatic cancers to gemcitabine through the suppression of multiple targets linked to tumorigenesis" - See Zyflamend at Amazon.com.
  • Acetyl-11-keto-β-boswellic acid suppresses invasion of pancreatic cancer cells through the downregulation of CXCR4 chemokine receptor expression - Int J Cancer. 2011 Feb 3 - "Ninety percent of cancer-mediated deaths are due to metastasis of the tumor; however, the mechanisms controlling metastasis remain poorly understood. Thus, no therapy targeting this process has yet been approved. Chemokines and their receptors are mediators of chronic inflammation and have been linked to the metastasis of numerous cancers. More recently, the Cysteine X Cysteine (CXC) chemokine receptor 4 (CXCR4) has emerged as a key mediator of tumor metastasis; therefore, identification of inhibitors of this receptor has the potential to abrogate metastasis. In this report, we demonstrate that acetyl-11-keto-β-boswellic acid (AKBA), a component of the therapeutic plant Boswellia serrata, can downregulate CXCR4 expression in pancreatic cancer cells. The reduction in CXCR4 induced by this terpenoid was found to be cell-type specific, as its expression was also abrogated in leukemia, myeloma and breast cancer cell lines. Neither proteasome inhibitors nor lysosomal stabilization could prevent the AKBA-induced reduction in CXCR4 expression. This downregulation occurred at the transcriptional level. Suppression of CXCR4 by AKBA was accompanied by the inhibition of pancreatic cancer cell invasion, which is induced by CXCL12, the ligand for CXCR4. In addition, abrogation of the expression of chemokine receptor by AKBA was found in human pancreatic tissues from orthotopic animal model. AKBA also abolished breast tumor cell invasion, and this effect correlated with the disappearance of both the CXCR4 messenger RNA and CXCR4 protein. Overall, our results show that AKBA is a novel inhibitor of CXCR4 expression and, thus, has the potential to suppress the invasion and metastasis of cancer cells" - See boswellia at Amazon.com
  • Omega-3, vitamins C and E may boost pancreatic health - Nutra USA, 9/9/10 - "consuming at least 850 milligrams of omega-3 fatty acids per day was associated with a 53 percent reduction in the risk of pancreatic cancer, compared to intakes of between 330 and 580 milligrams per day ... According to findings published in the International Journal of Cancer, benefits were also observed for intakes of vitamin C and E, the highest average intakes associated with 31 and 33 percent reductions, respectively, compared with the lowest average intakes" - [Abstract] - See Jarrow FamilE (contains all eight members of the vitamin E family, includes Tocomin) at Amazon.com and Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
  • Intake of fatty acids and antioxidants and pancreatic cancer in a large population-based case-control study in the San Francisco Bay Area - Int J Cancer. 2010 Oct 15;127(8):1893-904 - "Positive associations were observed for high levels of the 8 individual saturated fatty acids (4th vs. 1st quartile: ORs ranged from 1.6 to 2.6; all p(trend) < 0.01), monounsaturated palmitoleic and oleic fatty acids [OR = 1.6 (95% CI: 1.2-2.1) and 1.4 (95% CI: 1.1-1.9); both p(trend) < 0.01], and polyunsaturated linolenic acid [OR = 1.5 (95% CI: 1.1-2.0); p(trend) = 0.02]. Inverse associations were observed for high levels of gadolic acid [4th vs. 1st quartile: OR = 0.68 (95% CI: 0.50-0.92); p(trend) = 0.007] and omega-3 fatty acids [>or=0.85 g/day vs. 1st quartile: OR = 0.47 (95% CI: 0.25-0.90)]. An inverse association was also observed for high total intake of vitamin C [4th vs. 1st quartile: OR = 0.69 (95% CI: 0.51-0.94); p(trend) = 0.004] and of vitamin E [OR = 0.67 (95% CI: 0.49-0.92); p(trend) = 0.01]" - See Jarrow FamilE (contains all eight members of the vitamin E family, includes Tocomin) at Amazon.com and Mega Twin EPA at Amazon.com and Jarrow Max DHA at iHerb.
  • Pancreatic cancers use fructose, common in the Western diet, to fuel their growth - Science Daily, 8/2/10 - "The bottom line is the modern diet contains a lot of refined sugar including fructose and it's a hidden danger implicated in a lot of modern diseases, such as obesity, diabetes and fatty liver ... the pancreatic cancer cells could easily distinguish between glucose and fructose even though they are very similar structurally, and contrary to conventional wisdom, the cancer cells metabolized the sugars in very different ways. In the case of fructose, the pancreatic cancer cells used the sugar in the transketolase-driven non-oxidative pentose phosphate pathway to generate nucleic acids, the building blocks of RNA and DNA, which the cancer cells need to divide and proliferate"
  • New combination effective against pancreatic cancer: Substance in broccoli supports cancer therapy, study finds - Science Daily, 6/15/10 - "Sorafenib is used for advanced liver and kidney cancer and also appears to be effective against cancer stem cells in pancreatic cancer ... It inhibits resistant tumor stem cells and is also especially effective in combination with sulforaphane, an organic compound found in broccoli ... vegetables from the cruciferous family such as broccoli and cauliflower possess a high content of sulforaphane, an anti-cancer compound. The experiments show that sulforaphane prevents the activation of the NF-kB pathway by sorafenib. The combination treatment reinforces the effect of sorafenib without causing additional side effects" - See sulforaphane at Amazon.com.
  • Soft drink consumption may markedly increase risk of pancreatic cancer - Science Daily, 2/8/10 - "Consuming two or more soft drinks per week increased the risk of developing pancreatic cancer by nearly twofold compared to individuals who did not consume soft drinks" - [Abstract]
  • Curcumin active in pancreatic cancer patients - Nutra USA, 8/22/08
  • Herbal Extract Inhibits Development Of Pancreatic Cancer - Science Daily, 4/19/09
  • Mounting Evidence Shows Red Wine Antioxidant Kills Cancer - Science Daily, 3/25/08 - "Rochester researchers showed for the first time that a natural antioxidant found in grape skins and red wine can help destroy pancreatic cancer cells by reaching to the cell's core energy source, or mitochondria, and crippling its function ... The new study also showed that when the pancreatic cancer cells were doubly assaulted -- pre-treated with the antioxidant, resveratrol, and irradiated -- the combination induced a type of cell death called apoptosis, an important goal of cancer therapy" - [WebMD] - See resveratrol products at Amazon.com.
  • A Fiber-rich Diet May Cut Pancreatic Cancer Risk - oncologystat.com, 11/23/07 - "A diet high in whole grains and fiber may reduce the risk of developing pancreatic cancer by as much as 40%"
  • Dietary glycemic load, added sugars, and carbohydrates as risk factors for pancreatic cancer: the Multiethnic Cohort Study - Am J Clin Nutr. 2007 Nov;86(5):1495-501 - "Glycemic load and added sugars were not significantly associated with pancreatic cancer risk. The risk increased with higher intakes of total sugars, fructose, and sucrose, and the association with fructose was significant when the highest and lowest quartiles were compared (relative risk: 1.35; 95% CI: 1.02, 1.80; P for trend = 0.046). A significant association was found with fruit and juices intake (1.37; 1.02, 1.84; P for trend = 0.04) but not with soda intake. Statistical evidence of a significant interaction with body mass index was present only for sucrose intake (P = 0.04). A comparison of the highest and lowest quartiles of sucrose intake in overweight or obese participants gave a relative risk of 1.46 (0.95-2.25; P for trend = 0.04), but the comparison was not significant in normal-weight participants"
  • Apples and onions may slash pancreatic cancer risk - Nutra USA, 10/1/07 - "Of the three individual flavonols, they report that kaempferol was associated with the largest risk reduction (22 per cent) across all participants"
  • Mistletoe in Supportive Care for Colorectal and Pancreatic Cancers - Doctor's Guide, 7/12/07 - "Use of a fermented mistletoe extract (MEx; Iscador®) in long-term supportive care in hospitals and private practices demonstrated significant survival benefit and improvements in quality of life for patients with surgically treated primary, nonmetastatic colorectal carcinoma and for patients with all-stages pancreatic carcinoma, when combined with adjuvant chemotherapy and/or radiotherapy or passive aftercare in two multicentre, controlled, retrospective, epidemiological, observational, cohort studies"
  • Popular Herbal Supplement Hinders The Growth Of Pancreatic Cancer Cells - Science Daily, 4/17/07 - "an extract of triphala, the dried and powdered fruits of three plants, caused pancreatic cancer cells to die through a process called apoptosis -- the body's normal method of disposing of damaged, unwanted or unneeded cells. This process often is faulty in cancer cells" - See triphala products at iHerb.
  • Flavonol-rich diet may slash pancreatic cancer risk - Nutra USA, 4/16/07
  • Vitamin D May Cut Pancreatic Cancer Risk By Nearly Half - Science Daily, 9/12/06 - "taking the U.S. Recommended Daily Allowance of Vitamin D (400 IU/day) reduced the risk of pancreatic cancer by 43 percent ... Vitamin D has shown strong potential for preventing and treating prostate cancer, and areas with greater sunlight exposure have lower incidence and mortality for prostate, breast, and colon cancers"
  • High-vegetable Diet Linked To Protection Against Pancreatic Cancer - Science Daily, 9/19/05 - "fruits and vegetables -- particularly vegetables -- is associated with about a 50 percent reduction in the risk of developing pancreatic cancer"
  • More Vegetables Lowers Chance of Deadly Cancer - WebMD, 9/16/05
  • Dietary Intake of Lycopene Is Associated with Reduced Pancreatic Cancer Risk - J Nutr. 2005 Mar;135(3):592-597 - "After adjustment for age, province, BMI, smoking, educational attainment, dietary folate, and total energy intake, lycopene, provided mainly by tomatoes, was associated with a 31% reduction in pancreatic cancer risk among men"
  • Regular aspirin use linked to pancreatic cancer - USA Today, 10/28/03 - "women who reported 20 or more years of regular aspirin use, with an average intake of at least two or more tablets a week, had a 58% increased risk of pancreatic cancer, compared to those who did not take aspirin. Among those who took 14 tablets or more a week, the risk was 86% greater"
  • What vitamins or herbs do you suggest taking for cancer of the pancreas? - Dr. Weil, 6/5/03
  • Aspirin May Ward Off Pancreas Cancer - Intelihealth, 8/8/02
  • Aspirin Lowers Pancreatic Cancer Risk - WebMD, 8/6/02 - "A new study shows regular use of aspirin might lower your risk of one of the deadliest forms of cancer ... women who used aspirin cut their risk of developing pancreatic cancer nearly in half ... the more aspirin use a woman reported, the less likely she was to develop pancreatic cancer ... Other NSAIDs did not have the same effect"
  • Report: An Innovative Approach to Cancer Therapy - Life Extension Magazine, 8/01
  • B Vitamins Cut Cancer Risks - Nutrition Science News, 7/01
  • Unusual dietary treatment may fight pancreatic cancer - CNN, 11/29/99
  • A Promising Cancer Therapy - Life Extension Magazine, 7/99

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