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Home > Health Conditions > Calcification


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  • Attenuating effect of magnesium on pulmonary arterial calcification in rodent models of pulmonary hypertension - J Hypertens 2022 Oct 1 - "Vascular calcification has been considered as a potential therapeutic target in pulmonary hypertension. Mg2+ has a protective role against calcification ... Monocrotaline (MCT)-induced and chronic hypoxia-induced pulmonary hypertension ... Mg2+ supplement is a powerful strategy to treat pulmonary hypertension by mitigating pulmonary arterial calcification as the calcification triggered physiological and pathological changes to PASMCs" - See magnesium supplements at Amazon.com.
  • Capsaicin Attenuates Arterial Calcification Through Promoting SIRT6-Mediated Deacetylation and Degradation of Hif1α (Hypoxic-Inducible Factor-1 Alpha) - Hypertension 2022 Mar 2 - "Sustained Hif1α (hypoxic-inducible factor-1 alpha) accumulation plays a central role in osteogenic transdifferentiation and subsequent calcification. Capsaicin, the potent agonist of TRPV1 (transient receptor potential vanilloid type 1), was found to mitigate hypoxic-related injury and reverse phenotypic switch of vascular smooth muscle cells. However, its role in arterial calcification and the underlying mechanisms remain unexplored ... Capsaicin facilitates deacetylation and degradation of Hif1α by upregulating SIRT6, which inhibits osteogenic transdifferentiation and protects against arterial calcification" - See capsicum at Amazon.com.
  • The impact of vitamin K2 and native vitamin D supplementation on vascular calcification in pediatric patients on regular hemodialysis. A randomized controlled trial - Eur J Clin Nutr 2021 Nov 29 - "Vascular calcification is one of the most prevalent disorders in pediatric hemodialysis patients that eventually lead to cardiovascular morbidity. Vitamin K2 was investigated in adults in previous studies and showed favorable effects on calcification markers ... Vitamin K2 and native vitamin D showed a beneficial effect on calcification regulators in pediatric hemodialysis patients" - See vitamin k2 at Amazon.com and vitamin D at Amazon.com.
  • Vitamin K status, all-cause mortality, and cardiovascular disease in adults with chronic kidney disease: the Chronic Renal Insufficiency Cohort - Am J Clin Nutr 2021 Nov 12 - "Vascular calcification contributes to cardiovascular disease (CVD) and mortality in individuals with chronic kidney disease (CKD). Vitamin K-dependent proteins function as calcification inhibitors in vascular tissue ... All-cause mortality risk was 21-29% lower among participants with plasma (dp)ucMGP <450 pmol/L (n = 2361) compared to those with plasma (dp)ucMGP ≥450 pmol/L [adjusted HRs (95%CIs): < 300 pmol/L = 0.71(0.61, 0.83), 300-449 pmol/L = 0.77(0.66, 0.90)] and 16-19% lower among participants with plasma phylloquinone ≥0.50 nmol/L (n = 2421) compared to those with plasma phylloquinone <0.50 nmol/L [adjusted HRs: 0.50, 0.99 nmol/L = 0.84(0.72, 0.99), ≥1.00 nmol/L = 0.81(0.70, 0.95)]. The risk for atherosclerotic CVD events did not significantly differ across plasma (dp)ucMGP or phylloquinone categories" - See vitamin k2 at Amazon.com.
  • The effect of vitamin K1 on arterial calcification activity in subjects with diabetes mellitus: a post hoc analysis of a double-blind, randomized, placebo-controlled trial - Am J Clin Nutr 2021 Oct 12 - "In individuals with diabetes mellitus, supplementation with 10 mg vitamin K1/d may prevent the development of newly calcifying lesions within the aorta and the coronary arteries as detected using 18F-NaF PET. Further long-term studies are needed to test this hypothesis" - See vitamin K at Amazon.com and vitamin K at iHerb.com.
  • Statins, vascular calcification, and vitamin K-dependent proteins: Is there a relation? - Kaohsiung J Med Sci 2021 Feb 26 - "The present cross-sectional clinical study aimed to examine the connection between statin exposure, coronary artery calcification (CAC), and vitamin K-dependent proteins (VKDPs) in patients with cardiovascular (CV) conditions. Two groups of patients were studied: patients with established CV disease (CVD) and healthy patients at moderate risk for CVD (a control group). The groups were also split into statin users and non-users. The following VKDPs were measured in plasma: uncarboxylated Matrix Gla-protein (ucMGP), undercarboxylated (ucOC), and carboxylated osteocalcin (cOC), Gla-rich protein (GRP). CAC score (CACS) was determined by multislice computed tomography. Among all the participants in the study, CACS was more pronounced in statin users compared to non-users; the same was found also among the CVD patients and among the controls. While the levels of ucMGP and GRP did not differ between statin users and non-users, ucOC and ucOC/cOC were significantly elevated in statin users, indicating vitamin K deficiency. There was a positive correlation between the levels of ucOC and CACS in the entire population and in the group of statin users, but not in statin non-users. No association was found between ucMGP or GRP and CACS. Statins had also an impact on the international normalized ratio and interacted with vitamin K antagonists (VKAs). Our results are in agreement with the existing evidence about positive association between statins and vascular calcification. They enlighten to a certain extent the possible mechanisms through which statins may enhance calcium accumulation in arterial wall, namely, by inhibition of vitamin K dependent proteins and functions involved in vascular protection." -  [Nutra USA] - See vitamin k2 at Amazon.com.
  • Central Hemodynamics in Relation to Circulating Desphospho-Uncarboxylated Matrix Gla Protein: A Population Study - J Am Heart Assoc. 2019 Apr 2 - "Stiffening and calcification of the large arteries are forerunners of cardiovascular complications. MGP (Matrix Gla protein), which requires vitamin K-dependent activation, is a potent locally acting inhibitor of arterial calcification ... In people representative for the general population, higher inactive dp-uc MGP was associated with greater PWV , central pulse pressure, forward pulse wave, and backward pulse wave. These observations highlight new avenues for preserving vascular integrity and preventing cardiovascular complications (eg, by improving a person's vitamin K status)" - [Nutra USA] - See vitamin K at Amazon.com.
  • Serum Long-Chain n-3 Polyunsaturated Fatty Acids and Aortic Calcification in Middle-Aged Men: The Population-Based Cross-sectional ERA-JUMP Study -Nutrition, Metabolism and Cardiovascular Diseases, 05/23/2019 - "This study showed the significant inverse association of LCn-3PUFAs with aortic calcification independent of conventional cardiovascular risk factors among men in the general population. This association appeared to be driven by DHA but not EPA" - {Nutra USA] - See docosahexaenoic acid at Amazon.com.
  • The Bone—Vasculature Axis: Calcium Supplementation and the Role of Vitamin K - Front. Cardiovasc. Med., 05 February 2019 - "Data suggest that supplementing post-menopausal women with high doses of calcium has a detrimental impact on cardiovascular morbidity and mortality. Chronic kidney disease (CKD) patients are prone to vascular calcification in part due to impaired phosphate excretion. Calcium-based phosphate binders further increase risk of vascular calcification progression. In both bone and vascular tissue, vitamin K-dependent processes play an important role in calcium homeostasis and it is tempting to speculate that vitamin K supplementation might protect from the potentially untoward effects of calcium supplementation. This review provides an update on current literature on calcium supplementation among post-menopausal women and CKD patients and discusses underlying molecular mechanisms of vascular calcification. We propose therapeutic strategies with vitamin K2 treatment to prevent or hold progression of vascular calcification as a consequence of excessive calcium intake" - [Nutra USA] - See vitamin K2 at Amazon.com.
  • A need for bananas? Dietary potassium regulates calcification of arteries - Science Daily, 10/5/17 - "Bananas and avocados -- foods that are rich in potassium -- may help protect against pathogenic vascular calcification, also known as hardening of the arteries" - See potassium citrate at Amazon.com.
  • Long-term Metformin May Reduce Coronary Calcium - Medscape, 5/30/17 - "The prevalence and severity of coronary artery calcium (CAC) after 14 years of metformin therapy were significantly lower in men, but not women, who started on the drug for prediabetes ... although it is "hard to be sure" why the metformin effect is lacking in women, previous studies have shown that metformin reduces testosterone levels in women but not in men. "Whether there's a metabolic difference between women and men that might count for a differential effect of metformin is a possibility, but we really don't know the answer."" - See metformin at The Antiaging Store.S
  • erum magnesium is inversely associated with coronary artery calcification in the Genetics of Atherosclerotic Disease (GEA) study - Nutr J. 2016 Mar 1;15(1):22 - "After full adjustment, subjects in the highest quartile of serum magnesium had 48 % lower odds of hypertension (p = 0.028), 69 % lower odds of DM2 (p = 0.003), and 42 % lower odds of CAC score > 0 (p = 0.016) compared to those with the lowest serum magnesium. The analyses also showed that a 0.17 mg/dL (1SD) increment in serum magnesium was independently associated with 16 % lower CAC" - [Nutra USA] - See Jarrow Formulas, MagMind at Amazon.com.
  • Low serum magnesium is associated with coronary artery calcification in a Korean population at low risk for cardiovascular disease - Nutr Metab Cardiovasc Dis. 2015 Aug 13 - "low < 1.9 mg/dL (n = 931), normal = 1.9-2.3 mg/dL (n = 32,341), and high > 2.3 mg/dL ... The odds ratio for CAC in the low serum magnesium group compared to the normal group was 2.10 (1.40-3.15, P < 0.001) ... CONCLUSION: Low serum magnesium level is associated with CAC in a Korean population at low risk for cardiovascular disease. Further studies are needed to generalize this finding and to verify the causal relationship between low serum magnesium and CAC" - See magnesium supplements at Amazon.com.
  • High-Dose Menaquinone-7 Supplementation Reduces Cardiovascular Calcification in a Murine Model of Extraosseous Calcification - Nutrients. 2015 Aug 18 - "MK-7 supplementation inhibited cardiovascular calcification and decreased aortic alkaline phosphatase tissue concentrations. Furthermore, MK-7 supplementation increased aortic MGP messenger ribonucleic acid (mRNA) expression (10-fold; p < 0.05). CKD-induced arterial hypertension with secondary myocardial hypertrophy and increased elastic fiber breaking points in the arterial tunica media did not change with MK-7 supplementation. Our results show that high-dose MK-7 supplementation inhibits the development of cardiovascular calcification. The protective effect of MK-7 may be related to the inhibition of secondary mineralization of damaged vascular structures" - See MK-7 at Amazon.com.
  • Dietary Vitamin D Inadequacy Accelerates Calcification and Osteoblast-Like Cell Formation in the Vascular System of LDL Receptor Knockout and Wild-Type Mice - J Nutr. 2014 Mar 19 - "Vitamin D insufficiency is highly associated with cardiovascular morbidity and mortality. We have demonstrated enhanced vascular calcification in LDL receptor knockout (LDLR-/-) mice fed a diet low in vitamin D ... Collectively, the findings imply low vitamin D status as a causal factor for vascular calcification and atherosclerosis" - See vitamin D at Amazon.com.
  • Lower concentrations of serum phosphorus within the normal range could be associated with less calcification of the coronary artery in Koreans with normal renal function - Am J Clin Nutr. 2011 Oct 26 - "Serum phosphorus concentrations are associated with an increased risk of cardiovascular disease (CVD) and mortality in patients with renal insufficiency. This association has also been reported in Western individuals without chronic kidney disease (CKD) ... Compared with the group with a serum phosphorus concentration ≤3.3 mg/dL, the OR of an Agatston score >100 in individuals with a serum phosphorus concentration >3.6 to ≤3.9 mg/dL was 3.89 (95% CI: 1.43, 10.63; P = 0.008) and in those with a serum phosphorus concentration >3.9 mg/dL was 3.17 (95% CI: 1.19, 8.41; P = 0.021) ... A lower concentration of serum phosphorus within the normal range could be associated with less calcification of the coronary artery in Koreans with normal renal function"
  • Vitamin D Deficiency and Coronary Artery Calcification in Subjects with Type 1 Diabetes - Diabetes Care. 2010 Oct 26 - "Vitamin D deficiency independently predicts prevalence and development of coronary calcification, a marker of coronary artery plaque burden, in individuals with type 1 diabetes" - See vitamin D at Amazon.com.
  • Long-Term Marathon Running Linked With Increased Coronary Calcification - Medscape, 3/22/10 - "Compared with controls, marathoners had significantly more calcified plaque volume--274 mm3 for the marathoners and 169 mm3 for the controls--and higher calcium scores and noncalcified plaque volumes, although the latter two measures did not reach statistical significance"
  • Study strengthens Vitamin K1's heart benefits - Nutra USA, 5/26/09 - "Subjects receiving a daily vitamin K1 plus multivitamin supplement experienced 6 per cent less progression of coronary artery calcification (CAC), or hardening of the arteries that leads to atherosclerosis and cardiovascular disease" - [Abstract] - See vitamin K at Amazon.com.
  • Go ahead, sleep in — it’s good for the heart - msnbc.com, 12/23/08 - "About 12 percent of the people in the study developed artery calcification during the five-year study period. Among those who had slept less than five hours a night, 27 percent had developed artery calcification ... That dropped to 11 percent among those who slept five to seven hours, and to 6 percent among those who slept more than seven hours a night"
  • Vitamin K2 linked to better heart health - NutraUSA, 9/10/08 - "When the intakes of K1 and K2 were divided into four groups from the lowest to highest, no association was found between K1 intakes and calcification. However, high consumption of K2 (about 45 micrograms per day) was associated with 20 per cent decreased coronary calcification, compared with low consumption of K2 (about 18micrograms per day)" - See vitamin K at Amazon.com.
  • Vitamin K may reverse arterial calcification - Nutra USA, 4/3/07 - "using 10-week old male Wistar Kyoto rats ... high-vitamin K intake (both K1 and K2) not only blocked the progress of further calcium accumulation but also lead to a greater than 37 per cent reduction of previously accumulated arterial calcium precipitates within six weeks"

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