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Home > Health Conditions > Bladder Cancer

Bladder Cancer

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  • Radiosensitizing Effect of Curcumin on Human Bladder Cancer Cell Lines: Impact on DNA Repair Mechanisms - Nutr Cancer 2021 Oct 13 - "Chemo-radiotherapy is one of the promising approaches to treat bladder cancer, but its effectiveness is limited to sensitive patients. Polyphenol curcumin has shown anticancer and radiosensitizing potentials, but the mechanism is not fully understood ... curcumin treatment increased the radiosensitivity by modifying the DNA double-strand breaks repair kinetics of the most radioresistant cells UM-UC6 without affecting the radiosensitive UM-UC5. Moreover, UM-UC6 cell survival and proliferation was significantly decreased after the combination of curcumin with radiation. Bladder cell migration was also inhibited considerably. Curcumin was also shown to reduce the number and the volume of bladder cancer spheres of both cell lines. This study revealed that curcumin was able to radiosensitize resistant bladder cell line without affecting the sensitive one with minimal side effects through enhancing DNA damage signaling and repair pathway" - See curcumin at Amazon.com and iHerb.
  • Grain and dietary fiber intake and bladder cancer risk: a pooled analysis of prospective cohort studies - Am J Clin Nutr 2020 Aug 10 - "Higher intakes of total whole grain and total dietary fiber are associated with reduced risk of BC individually and jointly"
  • Curcumin inhibits bladder cancer stem cells by suppressing Sonic Hedgehog pathway - Biochem Biophys Res Commun. 2017 Sep 4 - "Altogether, these data suggested that curcumin inhibited the activities of BCSCs through suppressing Shh pathway, which might be an effective chemopreventive agent for bladder cancer intervention" - See curcumin products at Amazon.com.
  • Folate intake and risk of bladder cancer: a meta-analysis of epidemiological studies - Int J Food Sci Nutr. 2013 Dec 16 - "a meta-analysis of epidemiological studies published between 1996 and June 2013 on the relationship between folate intake and bladder cancer ... A significantly decreased risk with bladder cancer was observed in overall folate intake group (RE = 0.84; 95% CI, 0.72-0.96) and subgroup of case-control studies (RE = 0.73; 95% CI, 0.57-0.89), but not in cohort studies (RE = 0.96; 95% CI, 0.81-1.10) when comparing the highest with the lowest category of folate intake" - See folic acid products at Amazon.com.
  • Higher intake of fruits and vegetables may reduce the risk of bladder cancer in women - Science Daily, 8/23/13 - "analyzed data collected from 185,885 older adults over a period of 12.5 years, of which 581 invasive bladder cancer cases were diagnosed (152 women and 429 men) ... women who consumed the most fruits and vegetables had the lowest bladder cancer risk. For instance, women consuming the most yellow-orange vegetables were 52% less likely to have bladder cancer than women consuming the least yellow-orange vegetables. The data also suggested that women with the highest intake of vitamins A, C, and E had the lowest risk of bladder cancer. No associations between fruit and vegetable intake and invasive bladder cancer were found in men"
  • High levels of vitamin D in plasma protects against bladder cancer - Science Daily, 10/20/12 - "The authors of the study took blood samples from more than 2,000 individuals -- including patients with bladder cancer and control subjects free from the disease -- in 18 Spanish hospitals, making of this the largest study carried out to-date in this field. "We have seen that those subjects with the highest levels of 25(OH)D3, a stable form of vitamin D in the blood, are those who showed the lowest risk of suffering bladder cancer. These results indicate that high levels of this vitamin are associated with protection from the illness or, similarly, that low levels are associated with a higher risk of suffering from it," says Malats" - See vitamin D at Amazon.com.
  • Milk Consumption and Bladder Cancer Risk: A Meta-Analysis of Published Epidemiological Studies - Nutr Cancer. 2011 Nov 1 - "Studies investigating the association of milk consumption with bladder cancer risk have reported inconsistent findings. We conducted a meta-analysis of published cohort and case-control studies to pool the risk estimates of the association between milk intake and bladder cancer ... High milk intake was significantly associated with decreased risk of bladder cancer (OR, 0.84; 95% CI, 0.71-0.97) when comparing the highest with the lowest category of milk intake. The inverse association was stronger in Asia (OR, 0.60; 95% CI, 0.40-0.81) than North America (OR, 0.89; 95% CI, 0.76-1.03), and no association was observed in Europe (OR, 1.05; 95% CI, 0.85-1.26). This relationship also varied significantly by specific dairy products. Our results suggest that milk may be related to the reduction of bladder cancer risk. Further studies need to clarify the biological mechanisms"
  • Serum Vitamin D and Risk of Bladder Cancer - Cancer Res. 2010 Oct 26 - "lower 25(OH)D was associated with a statistically significantly increased risk of bladder cancer (versus ≥50 nmol/L; <25 nmol/L: OR, 1.73; 95% CI, 1.03-2.91; 25 to <37.5 nmol/L: OR, 1.81; 95% CI, 1.05-3.14; 37.5 to <50 nmol/L: OR, 1.76; 95% CI, 1.02-3.02; P trend = 0.04). Similarly, increased risks for the lowest vitamin D category were observed when season-specific quartiles were used (Q1 versus Q4: OR, 1.63" - See vitamin D at Amazon.com.
  • Selenium and Bladder Cancer Risk: a Meta-analysis - Cancer Epidemiol Biomarkers Prev. 2010 Aug 31 - "Overall, the risk of bladder cancer was inversely associated with elevated levels of selenium according to a random-effects model (mOR = 0.61; 95% CI, 0.42-0.87). The mORs were 0.95 (95% CI, 0.69-1.27) and 0.55 (95% CI, 0.32-0.95) among men and women, respectively"
  • Increasing selenium intake may decrease bladder cancer risk - Science Daily, 8/31/10 - "The lower the levels of selenium, the higher the risk of developing bladder cancer" - See selenium at Amazon.com.
  • Intake of Cruciferous Vegetables Modifies Bladder Cancer Survival - Cancer Epidemiol Biomarkers Prev. 2010 Jun 15 - "After an average of 8 years of follow-up, 179 deaths occurred, with 101 deaths attributable to bladder cancer. After adjustment for other prognostic factors, a strong and significant inverse association was observed between bladder cancer mortality and broccoli intake, in particular raw broccoli intake (>/=1 versus <1 serving per month; HR for overall death, 0.57; 95% CI, 0.39-0.83; HR for disease-specific death, 0.43; 95% CI, 0.25-0.74). There were no significant associations for total vegetables, total fruits, or other individual cruciferous vegetables" - See sulforaphane at Amazon.com.
  • Minerals and vitamins and the risk of bladder cancer: results from the New Hampshire Study - Cancer Causes Control. 2009 Dec 31 - "The ORs (95% CI) for highest quartile versus lowest quartile for total intake of vitamin E was 0.66 (0.36-1.20; p trend = 0.09) and 0.49 (0.21-1.17; p trend = 0.13) for dietary phosphorus. The odds of bladder cancer for heavy smokers with the highest total intake of vitamin E, carotenoids, and niacin were 0.58 (0.34-0.99), 0.62 (0.36-1.09), and 0.66 (0.39-1.14), respectively. Higher total intakes of carotenoids, vitamin D, thiamin, niacin, and vitamin E were inversely related to bladder cancer risk among older individuals"
  • Frankincense Oil -- A Wise Man's Remedy For Bladder Cancer - Science Daily, 3/24/09
  • Selenium May Prevent High Risk-bladder Cancer - Science Daily, 12/8/08
  • Yoghurt can benefit bladder cancer, say researchers - Nutra USA, 10/21/08 - "yoghurt consumption reduced the risk of cancer in men by 36 per cent and in women by 45 per cent. Other dairy products did not reveal such benefits and the researchers suggested this was down to the inherent functionality present in many yoghurts and not just those with boosted probiotic levels ... Cultured milk products, such as yoghurt, contain lactic acid bacteria, which have been shown to suppress bladder cancer in rats" - [Abstract] - See Yogourmet Electric Yogurt Maker and Nestle Nido Instant Milk Powder Mexico 1600g (3.5 Pounds) - Case of 6.  I mix the Nido full fat and Carnation non-fat (50/50).
  • Cultured milk, yogurt, and dairy intake in relation to bladder cancer risk in a prospective study of Swedish women and men - Am J Clin Nutr. 2008 Oct;88(4):1083-7 - "Total dairy intake was not significantly associated with risk of bladder cancer [> or =7.0 servings/d compared with < 3.5 servings/d: multivariate rate ratio (RR) = 0.87; 95% CI: 0.66, 1.15; P for trend = 0.33]. However, a statistically significant inverse association was observed for the intake of cultured milk (sour milk and yogurt). The multivariate RRs for the highest category of cultured milk intake (> or =2 servings/d) compared with the lowest category (0 serving/d) were 0.62 (95% CI: 0.46, 0.85; P for trend = 0.006) in women and men combined, 0.55 (95% CI: 0.25, 1.22; P for trend = 0.06) in women, and 0.64 (95% CI: 0.46, 0.89; P for trend = 0.03) in men. The intake of milk or cheese was not associated with bladder cancer risk ... These findings suggest that a high intake of cultured milk may lower the risk of developing bladder cancer"
  • Consumption of Raw Cruciferous Vegetables is Inversely Associated with Bladder Cancer Risk - Cancer Epidemiol Biomarkers Prev. 2008 Apr;17(4):938-44 - "We observed a strong and statistically significant inverse association between bladder cancer risk and raw cruciferous vegetable intake (adjusted OR for highest versus lowest category = 0.64; 95% CI, 0.42-0.97), with a significant trend (P = 0.003); there were no significant associations for fruit, total vegetables, or total cruciferous vegetables ... These data suggest that cruciferous vegetables, when consumed raw, may reduce the risk of bladder cancer, an effect consistent with the role of dietary isothiocyanates as chemopreventive agents against bladder cancer"
  • Effects of curcumin on bladder cancer cells and development of urothelial tumors in a rat bladder carcinogenesis model - Cancer Lett. 2008 Mar 12 - "Exposure of human bladder cancer cells to curcumin resulted in the induction of apoptotic cell death and caused cells to arrest in the G2/M phase. The anti-apoptotic Bcl-2 and Survivin protein was downregulated by the curcumin treatment together with enhancement of the Bax and p53 expression. The inhibitory activities of curcumin were stronger than those of cisplatin and could not be prevented by catalase pretreatment in T24 cells. Clonal assay indicated large-dose and short-term curcumin was lethal to bladder cancer cells. Moreover, the in vivo study revealed curcumin did induce apoptosis in situ, inhibit and slow the development of bladder cancer. These observations suggest that curcumin could prove an effective chemopreventive and chemotherapy agent for bladder cancer" - curcumin products at Amazon.com.
  • Extract Of Broccoli Sprouts May Protect Against Bladder Cancer - Science Daily, 2/28/08 - "A concentrated extract of freeze dried broccoli sprouts cut development of bladder tumors in an animal model by more than half" - [WebMD] - See indole-3-carbinol at Amazon.com and diindolylmethane at Amazon.com.
  • Is There an Anticancer Diet? - WebMD, 12/6/07 - "Raw cruciferous vegetables such as broccoli, broccoli sprouts, cabbage, and cauliflower seem to reduce bladder cancer risk by about 40%"
  • Green Tea May Protect Bladder From Becoming Inflamed - Science Daily, 5/20/07 - "catechins found in green tea protected both normal and cancerous bladder cells from inflammation when we exposed the cells to hydrogen peroxide ... these results indicate herbal supplements from green tea could be a treatment option for various bladder conditions that are caused by injury or inflammation" - See Green tea products at iHerb.  My favorite is Jarrow green tea.
  • Selenium is inversely associated with bladder cancer risk: A report from the Belgian case-control study on bladder cancer - Int J Urol. 2006 Sep;13(9):1180-4 - "This case-control study suggests an inverse association between serum selenium concentration and bladder cancer risk"
  • Broccoli Ingredient May Fight Bladder Cancer - WebMD, 8/3/05
  • Broccoli Packs Powerful Punch To Bladder Cancer Cells - Science Daily, 7/29/05 - "men who ate two or more half-cup servings of broccoli per week had a 44 percent lower incidence of bladder cancer compared to men who ate less than one serving each week ... The plant's kin, which include cabbage, cauliflower, Brussels sprouts and kale, may all contain similar disease-fighting phytochemicals"
  • Green Tea Extract Shows Potential As An Anti-cancer Agent - Science Daily, 2/23/05 - "green tea extract interrupts a process that is crucial in allowing bladder cancer to become invasive and spread to other areas of the body" - See iHerb or Vitacosticon green tea extracts.  My favorite is Jarrow green tea at iHerb.
  • New insight into green tea's action on bladder cancer - Nutra USA, 2/17/05
  • Green Tea's Record Against Cancer Grows - WebMD, 2/15/05 - "In effect, the green tea extract may keep the cancer cells confined and localized, where they are easier to treat and the prognosis is better ... you should drink four cups a day. Green tea supplements are also available, and at least one study has shown that you may actually get more powerful antioxidants from supplements than from drinking tea" - See iHerb or Vitacosticon green tea extracts.  My favorite is Jarrow green tea at iHerb.
  • Vitamin E Said To Cut Bladder Cancer Risk - Intelihealth, 3/29/04 - "Those whose vitamin E intake was in the top 25 percent had just half as much bladder cancer as those in the lowest quarter"
  • High Selenium Consumption May Protect Ex-Smokers From Bladder Cancer - Intelihealth, 10/31/02

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