Home > Anti-aging Research > Soy

Soy

Related Topics:

• isoflavones / phytoestrogens / hormone replacement therapy

Specific Recommendations:

• Soy products at iHerb
• soy isoflavones at Amazon.com
• Revival Soy Products

News & Research:

• Researchers use soy to improve bone cancer treatment - Science Daily, 9/15/20 - "Soybeans contain isoflavones, plant-derived estrogens that have been shown to impede cancer cell growth for many types of cancer without being toxic to normal cells. Isoflavones have also been shown to improve bone health and possibly prevent osteoporosis ... One of the soybean compounds caused a 90% reduction in bone cancer cell viability in their samples after 11 days. Two other soy compounds, meanwhile, significantly improved the growth of healthy bone cells. Furthermore, using the soy compounds in animal models also reduced inflammation, which could benefit bone health as well as overall recovery."
• Soy's Heart Benefits Hold Steady Over Time - WebMD, 7/1/19 - "Canadian researchers pored over the results of 46 separate trials. Their conclusion: "These data strongly support the rationale behind the original FDA heart health claim for soy," said study lead author David Jenkins, a professor of nutritional sciences and of medicine at the University of Toronto ... Co-author John Sievenpiper, also a professor of nutritional sciences at the university, stressed that the overall benefit of soy for heart health wasn't major -- just an average 5% reduction in cholesterol levels ... However, "if you put that together with other plant-based foods in a portfolio you get a much stronger effect," he said in a university news release ... The team's findings come as the FDA mulls possibly removing the right to a labeling claim that soy "may reduce the risk of heart disease," first approved by the agency in 1999"
• Soy formula feeding during infancy associated with severe menstrual pain in adulthood - Science Daily, 11/9/18 - "women who had ever been fed soy formula as babies were 50 percent more likely to have experienced moderate or severe menstrual discomfort between the ages of 18 and 22, and 40 percent more likely to have used hormonal contraception to help alleviate menstrual pain"
• Female Babies on Soy Formula Show Estrogenic Effects - Medscape, 3/13/18 - "Exposure to endocrine-disrupting compounds (EDCs) early in life may affect reproductive development ... In our observational study, when compared to infants who were fed cow’s milk formula, infants who were fed soy formula exclusively since birth demonstrated differences in uterine volume and urogenital epithelial cell characteristics over the first 7 to 9 months of life, consistent with an estrogen response ... These differences were not of clinical concern, and the potential long-term clinical consequences of these changes are unknown ... For mothers who prefer giving formula, AAP does not recommend soy formula for preterm infants, and cites very few indications for use among term infants, including galactosemia, hereditary lactase deficiency, or family preference for a vegetarian diet. Our study provides additional evidence in support of the AAP limited use recommendations"
• Soy supplements appear to be safe, beneficial in diabetic men - Science Daily, 6/23/14 - "Their study included 210 men ages 55 to 70 who had Type 2 diabetes and a borderline-low total testosterone level: less than or equal to 12 nanomoles per liter (nmol/L) or 345.8 nanograms per deciliter. For three months, the men ate two cereal bars a day, each containing 30 grams of soy protein. The bars in one group of 100 men contained 66 milligrams of soy phytoestrogens, which is equivalent to the amount in soy supplements or in a typical Southeast Asian diet. The second group of 100 men received soy protein bars in which phytoestrogens were removed ... On average, testosterone level increased from 9.8 to 11.3 nmol/L in the soy protein-phytoestrogen group and from 9.2 to 10.3 nmol/L in the group receiving only soy protein ... Soy protein with phytoestrogens also improved diabetes control much better than did soy protein alone. Specifically, the first group significantly lowered their fasting blood glucose (sugar) levels and hemoglobin A1c, a measure of blood sugar control over the past three months, as well as fasting insulin levels and estimated insulin resistance, which showed an improved use of the hormone insulin"
• Effects of Soy, Whey Protein Supplementation Post-Exercise - Science Daily, 10/12/13 - "Our main findings demonstrate that 14 days of supplementation with soy protein does appear to partially blunt serum testosterone. In addition, whey influences the response of cortisol following an acute bout of resistance exercise by blunting its increase during recovery"
• Soy and tomato may be effective in preventing prostate cancer - Science Daily, 5/8/13 - "From the time they were 4 to 18 weeks old, the animals were fed one of four diets: (1) 10 percent whole tomato powder; (2) 2 percent soy germ; (3) tomato powder plus soy germ; and (4) a control group that ate neither tomato nor soy ... Eating tomato, soy, and the combination all significantly reduced prostate cancer incidence. But the combination gave us the best results. Only 45 percent of mice fed both foods developed the disease compared to 61 percent in the tomato group, and 66 percent in the soy group ... The results of the mouse study suggest that three to four servings of tomato products per week and one to two servings of soy foods daily could protect against prostate cancer" - See Jarrow Lyco-Sorb (contains Lyco-O-Mato) at Amazon.com.
• Soy-based formula? Neonatal plant estrogen exposure leads to adult infertility in female mice - Science Daily, 5/2/12 - "A paper published May 2 in Biology of Reproduction describes the effects of brief prenatal exposure to plant estrogens on the mouse oviduct, modeling the effects of soy-based baby formula on human infants. The results suggest that exposure to estrogenic chemicals in the womb or during childhood has the potential to affect a woman's fertility as an adult, possibly providing the mechanistic basis for some cases of unexplained female infertility ... part of the National Institutes of Health, previously demonstrated that neonatal exposure to the plant estrogen genistein results in complete infertility in female adult mice. Causes of infertility included failure to ovulate, reduced ability of the oviduct to support embryo development before implantation, and failure of the uterus to support effective implantation of blastocyst-stage embryos ... The team now reports that neonatal exposure to genistein changes the level of immune response in the mouse oviduct, known as mucosal immune response. Some of the immune response genes were altered beginning from the time of genistein treatment, while others were altered much later, when the mouse was in early pregnancy. Together, those changes led to harmfully altered immune responses and to compromised oviduct support for preimplantation embryo development, both of which would likely contribute to infertility ... estrogenic chemical exposure to the female fetus, infant, child, and adolescent all have potential impacts on mucosal immunity in the reproductive tract and, therefore, on adult fertility. The authors present the view that limiting such exposures, including minimizing use of soy-based baby formula, is a step toward maintaining female reproductive health"
• Soy protein alleviates symptoms of fatty liver disease, study suggests - Science Daily, 4/22/12 - "Almost a third of American adults have fatty liver disease, many of them without symptoms ... Obesity is a key risk factor for this condition, which can lead to liver failure ... When fat accumulates in an organ that's not supposed to store fat -- like the liver, that organ's vital function can be dangerously compromised ... Chen compared fat accumulation in the livers of lean and obese rats, which were assigned to either a diet containing casein, a milk-based protein, or a diet containing soy protein, for 17 weeks after weaning ... While diet had no effect on the liver profiles of lean animals, the obese rats that were fed soy showed a 20 percent reduction in triglycerides and overall fat accumulation in the liver"
• Soy beats milk protein for cholesterol improvements: RCT - Nutra USA, 10/22/11 - "Results showed that, compared with carbohydrates, the soy protein was associated with a 3.97 mg/dl reduction in total cholesterol levels, and a 0.12 mg/dl reduction in the ratio of total:HDL cholesterol ... In addition, compared to milk protein, the soy protein was associated with a 1.54 mg/dl increase in HDL cholesterol levels and a 0.14 mg/dl decrease in the ratio of total:HDL cholesterol ... On the other hand, milk protein supplementation was significantly associated with a 1.13 mg/dL decrease in HDL levels, compared to carb supplement ... The effect of milk protein did not confer a significant favorable effect on any lipid measures compared with carbohydrate" - Note:  In addition to homemade yogurt, I been using Silk plus DHA Omega-3 on my cereal.  If you read the ingredients, it's probably not the best for you but it sure tastes good.  The soy adds variety over the milk used to make the yogurt.
• Soy isoflavones not a risk for breast cancer survivors, study finds - Science Daily, 4/5/11
• Soy isoflavones may modify risk of breast cancer - Science Daily, 11/8/10 - "Those women with the highest isoflavone intake had an approximately 30 percent decreased risk of having an invasive breast tumor, and an approximately 60 percent decreased risk of having a grade 1 tumor ... Among premenopausal women, the highest intake of isoflavones had a 30 percent decreased risk of stage I disease, a 70 percent decreased risk of having a tumor larger than 2 cm, and a 60 percent decreased risk of having stage 2 breast cancer. These connections were not seen among postmenopausal women" - See soy isoflavones at Amazon.com.
• Soy intake associated with lower recurrence of breast cancer in hormone-sensitive cancers - Science Daily, 10/18/10 - "The recurrence rate of estrogen- and progesterone- positive breast cancer was 12.9% lower among patients in the highest quartile of soy isoflavone intake than among those in the lowest quartile and was 18.7% lower for patients receiving anastrozole therapy in the highest quartile"
• Prebiotic-soy combination may boost heart health: Study - Nutra USA, 2/11/10
• Soy Appears Safe for Breast Cancer Survivors - WebMD, 12/8/09
• How Soy Reduces Diabetes Risk - Science Daily, 10/6/09 - "They found that daidzein and equol enhanced adipocyte differentiation, or the formation of fat cells, through activation of a key transcription regulator, the same receptor that mediates the insulin-sensitizing effects of anti-diabetes drugs. Thus, daidzein and equol daidzein and equol seem to work in a similar manner as anti-diabetic drugs currently in the market"
• Eat Soybeans To Prevent Diseases, New Research Suggests - Science Daily, 9/29/09
• Soy may help men remember anniversaries: Study - Nutra USA, 7/9/09 - "men receiving the isoflavones required 18 per cent fewer attempts to correctly complete the tasks, committed 23 per cent fewer errors, and achieved the tasks in 17 per cent less time than they did during the placebo phase" - [Abstract] - See soy isoflavones at Amazon.com.
• Superfood Soy Linked To Reduction In Smoker's Lung Damage Risk - Science Daily, 6/28/09 - "Soy consumption was found to be positively correlated with lung function and inversely associated with the risk of COPD. It has been suggested that flavonoids from soy foods act as an anti-inflammatory agent in the lung, and can protect against tobacco carcinogens for smokers"
• Teen soy intake linked to lower breast cancer risk - Nutra USA, 6/1/09 - "Adolescent intakes of soy foods were associated with a 43 per cent reduction in pre-menopausal breast cancer risk, while high intakes of soy protein and isoflavones were associated with 59 and 56 per cent reductions in the risk of breast cancer before the menopause" - [Abstract]
• Soybean Product Fights Abnormal Protein Involved In Alzheimer’s Disease - Science Daily, 2/20/09
• Soy: Bad for Sperm? - Dr. Weil, 12/15/08
• Soybean Component Reduces Menopause Effects - Science Daily, 4/11/09
• Soy Consumption Linked to Colorectal Cancer Risk in Postmenopausal Women - Medscape, 1/29/09 - "For each 5-g/day increment in dietary intake of soy as measured by dry weight (equivalent to approximately 1 oz [28.35 g] tofu/day), there was an 8% reduction in risk ... Compared with women in the lowest tertile of soy intake, those in the highest tertile had a multivariate relative risk (RR) of 0.67 ... were similar for soy protein and isoflavone intakes"
• Soy foods 'reduce sperm numbers' - BBC News, 7/23/08 - "A regular diet of even modest amounts of food containing soy may halve sperm concentrations" - [WebMD][Science Daily]
• Soy Compound May Halt Spread Of Prostate Cancer - Science Daily, 3/14/08 - "the amount of the chemical, an antioxidant known as genistein, used in the experiments was no higher than what a human would eat in a soybean-rich diet ... genistein decreased metastasis of prostate cancer to the lungs by 96 percent compared with mice that did not eat the compound in their chow" - See soy isoflavones at Amazon.com.
• Soy linked to less belly fat in postmenopausal women - Nutra USA, 1/14/08 - "At the end of the trial there were no differences in the weight of women in both groups ... However, measures of subcutaneous abdominal fat were significantly different between the groups, with women in the soy group experiencing a 14.7 sq. cm reduction compared to a 22.9 sq. cm increase in the placebo group" - [Abstract]
• A Different Side of Estrogen - Science News Online, 1/508 - "estrogen-like compounds called phytoestrogens are found in foods including soy and coffee. Some scientists have speculated that phytoestrogens played a key role in the lower incidence of prostate and breast cancers found for many years in Asian populations with soy-based diets"
• Is Soy Milk Safe? - Dr. Weil, 11/15/07
• How Does Soy Promote Weight Loss? - Science Daily, 5/1/07 - "when soy consumption goes up, weight goes down"
• Dietary Soy May Improve Features of Metabolic Syndrome in Postmenopausal Women - Medscape, 3/19/07 - "Fasting plasma glucose level decreased more on soy-nut diet vs soy-protein diet (-5.3%; P < .01) vs control ... LDL cholesterol level decreased more on soy-nut diet vs soy-protein diet (-5.0%; P < .01) vs control (-9.5%"
• Soy Found Protective Against Localized Prostate Cancer - Science Daily, 3/15/07 - "intake of genistein, daidzein, miso soup and soy food had no overall link to diagnosis of prostate cancer. However, they calculated that the risk of developing localized prostate cancer was 50 percent lower in men who ate the most isoflavones compared to men who ate the least meaning that men in the top category ate between two and three times as much isoflavone-rich food"
• Soy is making kids 'gay' - WorldNetDaily, 12/12/06
• Soy, Fish May Cut Cancer Risk - WebMD, 11/14/06 - "Women who ate the most soy as teens or adults were about 25% less likely to have breast cancer than those who skimped on it"
• Soy-rich diet cuts prostate cancer marker - Nutra USA, 6/22/06 - "Two servings of soy a day reduced levels of the prostate cancer marker PSA in free-living men by 14 percent, but didn’t affect testosterone levels"
• Concern over soy's effect on babies 'negligible' - USA Today, 3/19/06
• Soy protein, not isoflavones, lower blood lipids - Nutra USA, 3/2/06
• The New Low-Cholesterol Diet: Soy - WebMD, 2/13/06
• More support for soy's protection against prostate cancer - Nutra USA, 2/13/06 - "High intake of food items rich in phytoestrogens was associated with a decreased risk of prostate cancer. The odds ratio (OR) [the risk compared to a standard of 1.00] comparing the highest to the lowest quartile of intake was 0.74"
• Soy's Heart Benefits Questioned - WebMD, 1/23/06
• Study casts doubt on soy's heart benefits - MSNBC, 1/23/06 - "casting doubt on the health claim that soy-based foods and supplements significantly lower cholesterol ... neither soy nor the soy component isoflavone reduced symptoms of menopause, such as “hot flashes,” and that isoflavones don’t help prevent breast, uterine or prostate cancer. Results were mixed on whether soy prevented postmenopausal bone loss"
• Soy Phytoestrogens May Block Estrogen Effects - Science Daily, 1/16/06 - "the addition of high levels of dietary soy isoflavones tended to block estrogen effects in breast tissue. This finding suggests that postmenopausal women with higher levels of estrogen may derive the greatest benefit from soy"
• Soy Diet Worsens Heart Disease In Mice, Says University Of Colorado At Boulder Study - Science Daily, 1/9/06 - "the health of mice carrying a genetic mutation for a disease that is the leading cause of sudden cardiac death in people under 30 worsened considerably when the animals were fed a soy-based diet ... The research team hypothesized that heart deterioration in male mice was due at least in part to plant-based estrogens in the soy food diet that triggered a cascade of biochemical reactions and ultimately increased apoptosis, or programmed cell death, in the heart"
• Soy Is Still a Puzzle - MSNBC, 11/25/05
• Studies Find No Evidence That Estrogens In Soy Increase Uterine Cancer Risk - Science Daily, 11/4/05
• After Menopause: Eating Soy May Help Bones - WebMD, 9/12/05 - "Within 10 years of menopause, the 20% who ate the most soy foods reported half as many fractures as the 20% who ate the least soy ... The highest level of consumption among Chinese women was about 13 grams of soy protein a day. A cup of soy milk contains about 6.6 grams"
• Jury Still Out on Soy and Health - WebMD, 8/25/05
• Soybean Protein Supplementation May Reduce Systolic, Diastolic BP - Medscape, 7/5/05 - "randomized to receive 40 g of isolated soybean protein supplements daily ... the net blood pressure changes in the soy group after the intervention were -4.31 mm Hg systolic ... and -2.76 mm Hg diastolic"
• Soy Appears To Lower Cholesterol And Blood Sugar Levels, Aid Weight Loss - Science Daily, 6/10/05 - "The soy-based group lost slightly more weight in any given week, and displayed lower serum cholesterol and LDL cholesterol levels. Soy intake also produced small but significant reductions in serum glucose values"
• Soy protein could protect against breast cancer, say researchers - Nutra USA, 4/13/05 - "Eating soy protein on a regular basis may reduce a woman’s chance of developing breast cancer by up to 22 percent"
• Research Studies Effects Of Soy Baby Formula On Intestinal Development - Science Daily, 12/27/04 - "Two studies by University of Illinois food science and human nutrition professor Sharon Donovan show that the soy isoflavone genistein, in amounts present in commercial soy infant formulas, may inhibit intestinal cell growth in babies"
• Soy formula may inhibit intestinal development in babies - Nutra USA, 12/22/04 - "in newborn piglets fed a formula supplemented with genistein at the level found in soy formula, the number of proliferating cells in the intestine was 50 per cent lower than in piglets fed cow's milk formula alone"
• Soy to the Rescue? - Physician's Weekly, 11/22/04 - "isolated soy protein consumption significantly lowered urinary albumin excretion by 9.5%, total-to-HDL-C ratio by 0.45, LDL-C to HDL-C ratio by 0.20, and it raised HDL-C by 4.3%"
• Small daily soy intake cuts cholesterol - Nutra USA, 11/15/04
• Soy: Good for Men’s Health, Too - Healthwell, 11/11/04 - "There was a significant PSA-level drop in the men eating the soy bread compared with the control group"
• Soy Unlikely to Affect Women's Fertility - WebMD, 10/19/04
• Soy May Help Women Before Menopause - WebMD, 10/8/04 - "Soy seems to provide potent protection in monkeys, in terms of cholesterol levels. We presume the benefit would apply to premenopausal women as well"
• Eating More Soy-rich Foods Could Reduce Spread Of Breast Cancer - Science Daily, 9/29/04 - "eating a soy rich products such as soy milk, soy drinks and desserts, could have an important role in preventing the spread of cancer cells in the body"
• Soy Improves Prostate Cancer Outlook - WebMD, 9/24/04 - "adding about 2 ounces of soy each day for one month results in a 13% drop in total PSA and a 27% increase in the free-to-total PSA ratio in men with prostate cancer"
• Do Soy Foods Cause Cancer? - Dr. Weil, 8/12/04
• Soy Benefits Type 2 Diabetes - WebMD, 8/3/04 - "Diabetes is the leading cause of kidney failure.  The earliest sign of this complication is small amounts of protein in urine ... Those who added the soy protein powder to their diets had a 10% reduction in protein found in urine ... the soy protein supplement boosted "good" HDL cholesterol by 4%" - [Abstract]
• Isolated soy protein may help diabetes sufferers - Nutra USA, 8/2/04
• Soy Benefits May Have Age Cutoff - WebMD, 7/6/04 - "If supplementation begins a decade of so after menopause, it may be too late"
• Animal Research Suggests Plant Estrogens In Soy Do Not Increase Breast Cancer Risk - Science Daily, 7/6/04
• Lots of Soy Lessens Endometrial Cancer Risk - WebMD, 5/27/04 - "Regular intake of soya foods is associated with a reduced risk of endometrial cancer"
• New findings on soy and cancer prevention - Nutra USA, 5/13/04
• Soy Processing Influences Estrogen-dependent Breast Cancer Growth In Mice - Science Daily, 5/7/04
• Soy impact on heart health explained - Nutra USA, 4/6/04
• Soy: Prevent Prostate Cancer, Male Baldness? - WebMD, 3/30/04 - "A little-known molecule called equol ... is showing promise as a powerful blocker of a potent male hormone involved in prostate cancer, male baldness, even acne ... Actually, the protective effects occur when two chemicals in soy protein -- genistin and daidzin -- reach the digestive system, Setchell explains. There, they are metabolized to form genistein and daidzein. Daidzein is metabolized once again, to form equol"
• Can soy fight cancer? - MSNBC, 3/15/04 - "Soy contains several natural phytochemicals that act as antioxidants and possess structural similarities to estrogen. These substances can bind to estrogen receptors in many tissues, including the breast, uterus, bones and blood vessels. In some tissues, recent research shows that soy’s isoflavones may block the effects of estrogen, thus reducing cancer risk"
• Rethinking Soy? - Dr. Weil, 3/12/04
• Soy Protein Benefits Adult-Onset Diabetics - Healthwell Exchange Daily News, 1/8/04
• Soy Science - Natural Foods Merchandiser, 11/03
• Can Soy Feminize a Boy? - Dr. Weil, 11/10/03
• Crunch Soy Nuts for Good Health? - Dr. Weil, 10/3/03
• Soy For Prevention of Memory Decline Still Under Investigation - Doctor's Guide, 9/23/03
• Soy May Cut Endometrial Cancer Risk - WebMD, 8/5/03 - "consumption of isoflavones and lignans, but not coumestans, were associated with a reduced risk of endometrial cancer, particularly among postmenopausal women" - See Revival Soy Products.
• Soy Lowers PSA Levels in Some Men - WebMD, 5/1/03
• Soy Protein May Be Better Than Supplements for Menopause - WebMD, 4/24/03
• Soy Beneficial for Postmenopausal Women with Type 2 Diabetes - New Hope Natural Media, 11/14/02
• Soy Doesn't Improve Bones in Young Women - WebMD, 10/25/02
• Soy Helps Hearts for Some Diabetics - WebMD, 10/4/02
• Eating Lots of Tofu May Prevent Breast Cancer - WebMD, 10/2/02
• Got Milk - WebMD, 9/27/02 - "A combination of soy and cow's milk could have some beneficial, anti-cancer nutrients ... He says he thinks the most potent cancer-fighting component of soy is a compound called genistein ... He demonstrated that by feeding rats a diet containing genistein before exposing them to a cancer-causing drug. The number of breast tumors was reduced by 50%"
• Diet Rich In Soy Protein Lowers Estrogens Associated With Breast Cancer - Intelihealth, 9/24/02 - "Consuming tofu and other soy-based foods significantly lowers levels of a class of estrogens normally associated with breast cancer risk in postmenopausal women ... The study found a link between soy-rich diets consumed by Asian women in Singapore and reduced levels of an estrogen called estrone, the predominant form of estrogen in women following menopause ... estrone levels did not decline in a linear manner with increasing soy intake; an apparent reduction was only seen among those in the top 25 percent of soy protein consumers ... The study also showed that hormone levels remained unaffected by other dietary and lifestyle choices. These included consumption of alcohol, coffee, tea, fat, fiber and various micronutrients, including vitamins A, C and E, along with calcium and carotenoids ... There is a suggestion that weight change (particularly weight increase) has a profound influence on breast cancer rates in Asian-American women"
• Seeking soy as alternative to hormones - USA Today, 9/3/02
• Soy Milk Lowers Blood Pressure - New Hope Natural Media, 8/30/02 - "After three months, the average systolic blood pressure (the higher number) had decreased by 18.4 mm Hg and the diastolic blood pressure (the lower number) had fallen by 15.9 mm Hg in the soy group. This reduction is comparable to that seen with many prescription blood pressure-lowering drugs"
• Soy Protein In The Diet Produces Health Benefits, Regardless Of Isoflavone Content - Intelihealth, 7/25/02 - "After each soy diet, total cholesterol, the ratio of low-density lipoprotein (LDL) to high-density lipoprotein (HDL) cholesterol, homocysteine concentrations, and estimated overall cardiovascular risk were lower than they were after the control diet. Additionally, serum concentrations of LDL were lower after the high-isoflavone diet. The only significant difference between the sexes was a tendency toward reduced blood pressure in men after the high-soy isoflavone diet ... the soy diets continued to improve the subjects' blood lipid profiles even after dietary saturated fat consumption was maximally reduced"
• Women's Health & Soy? - Dr. Weil, 7/20/02
• Phytoestrogen review - ConsumerLab.com, 7/16/02
• Soy Comparable to Some Diabetes Drugs - WebMD, 6/20/02 - "Soy may help people with diabetes control their blood sugar as well as some prescription drugs ... One group sprinkled their food daily with a white powder containing 30 grams of soy protein and 132 milligrams of soy isoflavones for 12 weeks ... The soy products lowered the women's blood sugar as much as some prescription diabetes drugs"
• Soy Supplements May Help Control Blood Sugar - Intelihealth, 6/17/02 - "After 12 weeks, the women taking the soy supplement showed significantly better control over their blood sugar, according to several standard tests, and their levels of total cholesterol and low-density lipoprotein (so-called "bad cholesterol") dropped"
• Lab Study: Problem With Soy Chemical - Intelihealth, 5/21/02
• Soy Formulas May Weaken Immune System - WebMD, 5/20/02 - "the researchers examined immune system effects in mice fed diets high in the isoflavone. At levels similar to those found in soy-fed infants, genistein appeared to produce a large decrease in thymus size and immune cell function ... The study appears to contradict recently published research, sponsored by a soy formula manufacturer, suggesting that infants fed soy-based diets have normal immune development as measured by response to routine childhood immunizations. Infants fed soy-based formulas also demonstrated immune status similar to infants who were breastfed ... But a Danish study assessing soy supplementation in postmenopausal women did find evidence of immune suppression"
• Tofupill Phytoestrogen Preparation Relieves Menopausal Symptoms without Unwanted Estrogenic Effects - Doctor's Guide, 5/6/02
• New Evidence That Dietary Soy And Flaxseed Have Positive Effect On Obesity And Diabetes - Intelihealth, 4/22/02 - "Earlier studies in obese animals and humans have suggested that soy, as a source of dietary protein, has significant anti-obesity effects. A study conducted in genetically obese mice found that soy protein and its hydrolsate were more effective than whey protein in weight reduction. This effect may be due to an active tetrapeptide present in soy. Several studies reported increased insulin sensitivity in rats fed isolated soy proteins compared with rats fed casein. A 37-kDa protein in soy appears to modulate insulin action on fat decomposition ... These data suggest that diets rich in soy protein and flaxseed have beneficial effects on many aspects of obesity and diabetes"
• Hot Flash Relief - WebMD, 4/10/02 - "Soy may give hot-flash relief ... Flaxseed is another option ... Flaxseed oil won't work, because oil does not contain phytoestrogens, the plant form of estrogen. You must grind the flaxseeds; if you don't, the whole seeds will just pass through your digestive system"
• Eating Away At High Cholesterol Levels - Functional Foods & Nutraceuticals, 4/02
• Soy Fights Pain - WebMD, 3/15/02
• Long-Term Soy Consumption Does Not Effect Hormones In Postmenopausal Women - Intelihealth, 12/21/01 - "Though small hormonal fluctuations occurred in all three groups over time, the researchers found no significant changes in serum estrogen, cortisol, dehydroepiandrosterone sulfate, or follicle stimulating hormone in any of the subject groups. Circulating thyroid hormone levels were modestly increased in women taking the highest dose of soy isoflavones for more than 6 months. Other effects of soy isoflavones observed in the study, such as increased bone mineral density and higher HDL concentrations in women who took the highest dose for 6 months, suggest that soy may possess estrogen effects that are better reflected in these end-points rather than in serum hormone concentrations"
• New study shows soy products may be harmful to some - Healthscout, 9/26/01 - "New research shows soy-based products could increase the risk of developing this painful urinary tract condition [kidney stones] ... The culprit is oxalate, a compound in plants that recently was discovered to be abundant in the soybean ... patients with calcium oxalate kidney stones limit oxalate levels to no more than 10 milligrams per serving ... Other high-oxalate foods include legumes like refried beans, lentils and peanuts, each containing between 100 and 200 milligrams of oxalate per serving ... For most folks oxalate, which has no nutritive value of its own, is not a problem"
• Soy Infant Formulas Get Clean Bill of Reproductive Health - WebMD, 8/15/01
• Is Soy Better Than Estrogen for Heart Health After Menopause? - WebMD, 7/2/01 - "This research is interesting as it suggests soy can favorably affect cholesterol without adversely affecting blood clotting, which is a potential concern with estrogen replacement ... benefits were seen equally in men and women, [and] soy treatment did not affect male sexuality"
• Soy Does Not Activate Blood Clotting Mechanisms - Doctor's Guide, 6/22/01 - "We know that soy reduces cholesterol and blood pressure, so it appears to be a healthy intervention, and it does not appear to increase the risk of blood clotting, so it continues to be a safe dietary recommendation for patients"
• Soy Isoflavones May Protect Postmenopausal Women From Alzheimer's - WebMD, 4/3/01
• Not for Ladies Only: Soy May Also Help Men at Risk for Osteoporosis - WebMD, 4/2/01 - "research suggests that a diet enriched with soy protein, which some research has shown can help preserve women's bones, may be able to do the same thing for men ... The group consuming soy protein had significantly more of this growth factor"
• Topically Applied Soy May Benefit Acne - Doctor's Guide, 3/5/01
• Soy Story: Can Supplements Help Diabetics Avoid Heart Disease? - WebMD, 2/21/01 - "patients' cholesterol levels were significantly lower after the six weeks of soy supplements than it was when measured after taking the inactive placebo drug. Among their findings: LDL or "bad cholesterol" levels decreased significantly with the soy"
• Soy and Health: What's the Scoop? Most Recent Addition to Soy Research Shows Lower Breast Cancer Risk - WebMD, 12/21/00
• Heart Association recommends eating more soy - CNN, 11/14/00
• Research Reveals Soy, Niacin, and Tea Offer Protection From Heart Attack and Stroke - WebMD, 11/13/00
• Bone Up on Osteoporosis - Nutrition Science News, 11/00
• Calcium Less Available from Soy Milk - Nutrition Science News, 10/00
• Soy Isoflavones Reduce Bone Loss In Perimenopausal Women - Doctor's Guide, 9/1/00
• Easing Into Menopause, Hot Flashes and Irregular Periods Can Last a Decade - WebMD, 8/30/00
• Isoflavone Concentrations Of Different Soy Foods - Nutrition Science News, 8/00
• Any Soy Has Isoflavones - Nutrition Science News, 8/00
• Hot Flash for Women at Menopause - Try a Little Tofu - WebMD, 7/7/00
• How good is soy? - CNN, 6/26/00
• Thirty-Eight Studies Find Soy Products Lower Cholesterol - Medscape, 6/23/00
• Study Shows Soy Lowers Cholesterol, Doesn't Contribute to Cancer - WebMD, 4/12/00
• Natto: The Newest Soy - Nutrition Science News, 4/00
• Study Disproves Soy as Aid in Fighting Hot Flashes - Medscape, 2/29/00
• And FDA Said: Let Them Eat Soy - Nutrition Science News, 1/00
• Jury Still Out On Plant Estrogens - Doctor's Guide, 12/9/99
• Anti-Cancer Agent Sought In Soybean - Intelihealth, 9/20/99
• Cholesterol-Lowering Drugs, Soy Milk And Tomato Extract All Reduce Cancer Risk - Doctor's Guide, 4/16/99
• Isoflavone Concentration in Soyfoods - Indiana Soybean Board
• Soy Phytoestrogens Prevent Stroke As Much As Premarin - Doctor's Guide, 3/20/98
• Key Ingredient In Soy Is What Lowers Cholesterol - Doctor's Guide, 3/20/98
• Diet Can Reduce Risk Of Breast Cancer - Doctor's Guide, 10/3/97
• Soy Intake May Reduce Risk of Uterine Cancer -- New Cancer Research Study in Hawaii - Doctor's Guide, 8/29/97
• Studies Show Soy Protein May Prevent, Treat Bone Loss, Doctor's Guide, 6/30/97 - "Dr. John W. Erdman, Jr., author of the study, found that "results indicated significant increases in both bone mineral content and bone density in the lumbar spine" for women with a high soy diet."
• "Miracle Bean" Plays Major Role in Foods, Medicine, Industry - Doctor's Guide, 3/25/97
• Soy Intake May Reduce Risk of Uterine Cancer -- New Cancer Research Study - Doctor's Guide, 8/29/97
• High Levels Of Plant Estrogen Found Soy-Based Baby Milk- Doctor's Guide, 7/4/97
• Studies Show Soy Protein May Prevent, Treat Bone Loss - Doctor's Guide, 6/30/97

• Dietary soybeans worsen dextran sodium sulfate-induced colitis by disrupting intestinal ecology - Food Funct 2022 May 18 - "the intake of soybeans and soybean carbohydrates is not conducive to recovery from IBDs based on changes in gut microbiota and metabolites affecting the activities of macrophages."
• Soya and isoflavone intakes associated with reduced risk of oesophageal cancer in north-west China - Public Health Nutr. 2014 Mar 27:1-5 - "The oesophageal cancer patients consumed significantly less (P < 0.001) total soya foods (mean 57.2 (sd 119.0) g/d) and soya milk (mean 18.8 (sd 51.7) ml/d) than the controls (mean 93.3 (sd 121.5) g/d and mean 35.7 (sd 73.0) ml/d). Logistic regression analyses showed an inverse association between intake of soya products and the risk of oesophageal cancer. The adjusted odds were OR = 0.33 (95 % CI 0.22, 0.49) and OR = 0.48 (95 % CI 0.31, 0.74) for consuming at least 97 g of soya foods and 60 ml of soya milk daily (the highest tertiles of consumption), respectively, relative to the lowest tertiles of consumption. Similarly, inverse associations with apparent dose-response relationships were found between isoflavone intakes and oesophageal cancer risk"
• The effects of soy and whey protein supplementation on acute hormonal reponses to resistance exercise in men - J Am Coll Nutr. 2013 Feb;32(1):66-74 - "For many resistance-trained men concerns exist regarding the production of estrogen with the consumption of soy protein when training for muscle strength and size. Thus, the purpose of this investigation was to examine the effects of soy and whey protein supplementation on sex hormones following an acute bout of heavy resistance exercise in resistance trained men ... Ten resistance-trained men (age 21.7 +/- 2.8 [SD] years; height 175.0 +/- 5.4 cm; weight 84.2 +/- 9.1 kg) volunteered to participate in an investigation ... all subjects completed 3 experimental treatment conditions supplementing with whey protein isolate (WPI), soy protein isolate (SPI), and maltodextrin placebo control for 14 days with participants ingesting 20 g of their assigned supplement each morning at approximately the same time each day ... This investigation observed lower testosterone responses following supplementation with soy protein in addition to a positive blunted cortisol response with the use of whey protein at some recovery time points. Although sex hormone binding globulin (SHBG) was proposed as a possible mechanism for understanding changes in androgen content, SHBG did not differ between experimental treatments. Importantly, there were no significant differences between groups in changes in estradiol concentrations" - See whey protein at Amazon.com.
• Whey protein supplementation during resistance training augments lean body mass - J Am Coll Nutr. 2013 Apr;32(2):122-35 - "Compared to soy, whey protein is higher in leucine, absorbed quicker and results in a more pronounced increase in muscle protein synthesis ... randomized non-resistance-trained men and women into groups who consumed daily isocaloric supplements containing carbohydrate (carb; n = 22), whey protein (whey; n = 19), or soy protein (soy; n = 22) ... Lean body mass gains were significantly (p < 0.05) greater in whey (3.3 +/- 1.5 kg) than carb (2.3 +/- 1.7 kg) and soy (1.8 +/- 1.6 kg). Fat mass decreased slightly but there were no differences between groups. Fasting concentrations of leucine were significantly elevated (20%) and postexercise plasma leucine increased more than 2-fold in whey. Fasting leucine concentrations were positively correlated with lean body mass responses"
• Soy Milk Consumption and Blood Pressure Among Type 2 Diabetic Patients With Nephropathy - J Ren Nutr. 2013 Mar 13 - "randomized, crossover, controlled clinical trial was conducted in 29 type 2 diabetic patients with nephropathy. Participants were randomly assigned to consume a diet containing soy milk, or a diet containing cow's milk, each for 4 weeks ... Consumption of soy milk resulted in a significant reduction in systolic blood pressure compared with consumption of cow's milk (percent change: -4.50 vs. 5.89%; P = .03). Serum triglyceride levels decreased significantly after soy milk consumption (percent change: -15.22 vs. 2.37%; P = .02). After adjustment for carbohydrate intake, the effect of soy milk on triglyceride level was not significant. There were no significant differences between soy milk and cow's milk consumption in terms of their effect on cardiovascular risks and markers of kidney function"
• Soy isoflavone intake and breast cancer risk in Japan: From the takayama study - Int J Cancer. 2013 Feb 6 - "We assessed the associations of soy and isoflavone intake with breast cancer incidence in a population-based prospective cohort study in Japan. Participants were members from the Takayama study, aged 35 years or older in 1992 ... Soy and isoflavone intakes were assessed with a validated food-frequency questionnaire ... The relative risks of postmenopausal breast cancer were lower among women with higher intakes of soy (trend p=0.023) and isoflavone (trend p=0.046), although the relative risks of premenopausal breast cancer were not associated with intakes of soy and isoflavone. Decreased risks of breast cancer were found even among women with a moderate intake of soy and isoflavone. These results suggested that soy and isoflavone intake have a protective effect on postmenopausal breast cancer"
• Soya isoflavone consumption in relation to carotid intima-media thickness in Chinese equol excretors aged 40-65 years - Br J Nutr. 2012 Feb 29:1-7 - "Previous studies have suggested that the daidzein metabolite equol rather than daidzein itself contributes to the beneficial effect of soya foods in the prevention of CVD. The aim of the present study is to examine the proportion of equol excretion in Chinese adults and compare plasma lipids and carotid artery intima-media thickness (IMT) between equol excretors and non-excretors, and to evaluate the effect of soya isoflavone intakes on serum lipids and IMT in either equol excretors or non-excretors ... Compared with non-excretors, equol excretors showed significantly lower serum TAG ( - 38.2 (95 % CI - 70.4, - 5.9) %, P = 0.012) and CCA-IMT ( - 4.9 (95 % CI - 9.7, - 0.3) %, P = 0.033). Equol excretors with higher daily isoflavone intakes ( - 5.4 mg/d) had significantly lower IMT ( - 16.2 %, P = 0.035) and tended to have higher HDL-cholesterol (P = 0.055) than did those with lower daily isoflavone intakes (1.5 mg/d), while no association was observed between soya isoflavone intakes and serum lipids or IMT in non-excretors. In conclusion, the benefits of soya isoflavones in preventing CVD may be apparent among equol excretors only"
• Differential Influence of Dietary Soy Intake on the Risk of Breast Cancer Recurrence Related to HER2 Status - Nutr Cancer. 2012 Jan 2 - "Legume intake (mostly from black soybeans) was inversely associated with the risk of breast cancer recurrence in HER2 negative cancer patients (HR: 0.27, 95% CI: 0.13-0.57, P for trend < 0.01), whereas legume intake was positively associated in HER2 positive cancer patients (P for trend = 0.02). In HER2 negative cancer patients, isoflavone was inversely associated with breast cancer recurrence (HR: 0.23, 95% CI: 0.06-0.89; P for trend = 0.01). Total soy intake was not associated with an increased risk of cancer recurrence. In conclusion, overall soy food intake might not affect the risk of cancer recurrence, but high intake of soy isoflavones increased the risk of cancer recurrence in HER2-positive breast cancer patients. However, further research is needed to confirm these results due to the small number of cancer recurrence events"
• Soy intake is associated with lower lung cancer risk: results from a meta-analysis of epidemiologic studies - Am J Clin Nutr. 2011 Nov 9 - "A total of 11 epidemiologic studies that consisted of 8 case-control and 3 prospective cohort studies were included. A significantly inverse association was shown between soy intake and lung cancer with an overall RR of 0.77 (95% CI: 0.65, 0.92). Findings were slightly different when analyses were restricted to 5 high-quality studies (RR: 0.70; 95% CI: 0.45, 0.99). In a subgroup meta-analysis, a statistically significant protective effect of soy consumption was observed in women (RR: 0.79; 95% CI: 0.67, 0.93), never smokers (RR: 0.62; 95% CI: 0.51, 0.76), and Asian populations (RR: 0.86; 95% CI: 0.74, 0.98)"
• Effect of soy and milk protein supplementation on serum lipid levels: a randomized controlled trial - Eur J Clin Nutr. 2011 Sep 28 - "Previous clinical trials have documented that soy protein reduces low-density lipoprotein cholesterol and increases high-density lipoprotein (HDL) cholesterol compared with milk protein ... Compared with carbohydrate, soy protein supplementation was significantly associated with a net change (95% confidence interval (CI)) in total cholesterol and total/HDL cholesterol ratio of -3.97 mg/dl (-7.63 to -0.31, P=0.03) and -0.12 (-0.23 to -0.01, P=0.03), respectively. Compared with milk protein, soy protein supplementation was significantly associated with a net change (95% CI) in HDL and total/HDL cholesterol ratio of 1.54 mg/dl (0.63 to 2.44, P=0.0009) and -0.14 (-0.22 to -0.05, P=0.001), respectively. Compared with carbohydrate, milk protein supplementation was significantly associated with a net change (95% CI) in HDL of -1.13 mg/dl (-2.05 to -0.22, P=0.02). Conclusions: This randomized controlled trial indicates that soy protein, but not milk protein, supplementation improves the lipid profile among healthy individuals"
• Effect of Dietary Protein Supplementation on Blood Pressure: A Randomized, Controlled Trial - Circulation. 2011 Jul 18 - "The trial participants were assigned to take 40 g/d soy protein, milk protein, or carbohydrate supplementation each for 8 weeks in a random order. A 3-week washout period was implemented between the interventions. Three BPs were measured at 2 baseline and 2 termination visits during each of 3 intervention phases with a random-zero sphygmomanometer. Compared with carbohydrate controls, soy protein and milk protein supplementations were significantly associated with -2.0 mm Hg (95% confidence interval -3.2 to -0.7 mm Hg, P=0.002) and -2.3 mm Hg (-3.7 to -1.0 mm Hg, P=0.0007) net changes in systolic BP, respectively. Diastolic BP was also reduced, but this change did not reach statistical significance. There was no significant difference in the BP reductions achieved between soy or milk protein supplementation"
• Alternative Healthy Eating Index and mortality over 18 y of follow-up: results from the Whitehall II cohort - Am J Clin Nutr. 2011 May 25 - "Indexes of diet quality have been shown to be associated with decreased risk of mortality in several countries. It remains unclear if the Alternative Healthy Eating Index (AHEI), designed to provide dietary guidelines to combat major chronic diseases, is related to mortality risk. OBJECTIVE: We aimed to examine the association between adherence to the AHEI and cause-specific mortality over 18 y of follow-up in a British working population. Design: Analyses are based on 7319 participants (mean age: 49.5 y; range: 39-63 y; 30.3% women) from the Whitehall II Study. Cox proportional hazards regression models were performed to analyze associations of the AHEI (scored on the basis of intake of 9 components: vegetables, fruit, nuts and soy, white or red meat, trans fat, polyunsaturated or saturated fat, fiber, multivitamin use, and alcohol) with mortality risk. Results: After potential confounders were controlled for, participants in the top compared with the bottom third of the AHEI score showed 25% lower all-cause mortality [hazard ratio (HR): 0.76; 95% CI: 0.61, 0.95] and >40% lower mortality from cardiovascular disease (CVD; HR: 0.58; 95% CI: 0.37, 0.91). Consumption of nuts and soy and moderate alcohol intake appeared to be the most important independent contributors to decreased mortality risk. The AHEI was not associated with cancer mortality or noncancer/non-CVD mortality. Conclusion: Our findings suggest that the encouragement of adherence to the AHEI dietary recommendations constitutes a valid and clear public health recommendation that would decrease the risk of premature death from CVD"
• Effect of soya protein on blood pressure: a meta-analysis of randomised controlled trials - Br J Nutr. 2011 Feb 23:1-10 - "Meta-analyses of twenty-seven RCT showed a mean decrease of 2.21 mmHg (95 % CI - 4.10, - 0.33; P = 0.021) for systolic BP (SBP) and 1.44 mmHg (95 % CI - 2.56, - 0.31; P = 0.012) for diastolic BP (DBP), comparing the participants in the soya protein group with those in the control group. Soya protein consumption significantly reduced SBP and DBP in both hypertensive and normotensive subjects, and the reductions were markedly greater in hypertensive subjects. Significant and greater BP reductions were also observed in trials using carbohydrate, but not milk products, as the control diet. Meta-regression analyses further revealed a significantly inverse association between pre-treatment BP and the level of BP reductions. In conclusion, soya protein intake, compared with a control diet, significantly reduces both SBP and DBP, but the BP reductions are related to pre-treatment BP levels of subjects and the type of control diet used as comparison"
• Soy food and isoflavone intake and colorectal cancer risk: the Fukuoka Colorectal Cancer Study - Scand J Gastroenterol. 2010 Oct 24 - "Energy-adjusted intakes of soy foods (dry weight) and isoflavones were inversely associated with colorectal cancer risk in men and postmenopausal women, but not in premenopausal women. The multivariate-adjusted OR for the highest versus lowest quintile was 0.65 (95% CI 0.41-1.03, p for trend = 0.03) for soy foods and 0.68 (95% CI 0.42-1.10, p for trend = 0.051) for isoflavones in men. The corresponding values for postmenopausal women were 0.60 (95% CI 0.29-1.25, p for trend = 0.053) and 0.68 (95% CI 0.33-1.40, p for trend = 0.049)"
• Soy isoflavones in conjunction with radiation therapy in patients with prostate cancer - Nutr Cancer. 2010 Oct;62(7):996-1000 - "Soy isoflavones sensitize prostate cancer cells to radiation therapy by inhibiting cell survival pathways activated by radiation. At the same time, soy isoflavones have significant antioxidant and anti-inflammatory activity, which may help prevent the side effects of radiation ... Adverse effects of radiation therapy on bladder, bowel, and sexual function were assessed by a self-administered quality of life questionnaire at 3 and 6 mo. Only 26 and 27 patients returned completed questionnaires at 3 and 6 mo, respectively. At each time point, urinary, bowel, and sexual adverse symptoms induced by radiation therapy were decreased in the soy isoflavone group compared to placebo group. At 3 mo, soy-treated patients had less urinary incontinence, less urgency, and better erectile function as compared to the placebo group. At 6 mo, the symptoms in soy-treated patients were further improved as compared to the placebo group. These patients had less dripping/leakage of urine (7.7% in Group 1 vs. 28.4% in Group 2), less rectal cramping/diarrhea (7.7% vs. 21.4%), and less pain with bowel movements (0% vs. 14.8%) than placebo-treated patients. There was also a higher overall ability to have erections (77% vs. 57.1%). The results suggest that soy isoflavones taken in conjunction with radiation therapy could reduce the urinary, intestinal, and sexual adverse effects in patients with prostate cancer" - See soy isoflavones at Amazon.com.
• Soy food intake and breast cancer survival - JAMA. 2009 Dec 9;302(22):2437-43 - "Soy food intake, as measured by either soy protein or soy isoflavone intake, was inversely associated with mortality and recurrence. The hazard ratio associated with the highest quartile of soy protein intake was 0.71 (95% confidence interval [CI], 0.54-0.92) for total mortality and 0.68 (95% CI, 0.54-0.87) for recurrence compared with the lowest quartile of intake. The multivariate-adjusted 4-year mortality rates were 10.3% and 7.4%, and the 4-year recurrence rates were 11.2% and 8.0%, respectively, for women in the lowest and highest quartiles of soy protein intake. The inverse association was evident among women with either estrogen receptor-positive or -negative breast cancer and was present in both users and nonusers of tamoxifen. CONCLUSION: Among women with breast cancer, soy food consumption was significantly associated with decreased risk of death and recurrence"
• Soya isoflavone supplementation enhances spatial working memory in men - Br J Nutr. 2009 Jun 1:1-7 - "Compared with placebo supplementation, there were 18 % fewer attempts (P = 0.01), 23 % fewer errors (P = 0.02) and 17 % less time (P = 0.03) required to correctly identify the requisite information" - See soy isoflavones at Amazon.com.
• Clinical studies show no effects of soy protein or isoflavones on reproductive hormones in men: results of a meta-analysis - Fertil Steril. 2009 Jun 11 - "No significant effects of soy protein or isoflavone intake on T, SHBG, free T, or FAI were detected regardless of statistical model"
• Adolescent and adult soy food intake and breast cancer risk: results from the Shanghai Women's Health Study - Am J Clin Nutr. 2009 Jun;89(6):1920-6 - "Adult soy food consumption, measured either by soy protein or isoflavone intake, was inversely associated with the risk of premenopausal breast cancer, and the association was highly statistically significant (P for trend < 0.001). The multivariate-adjusted relative risks (RRs) for the upper intake quintile compared with the lowest quintile were 0.41 (95% CI: 0.25, 0.70) for soy protein intake and 0.44 (95% CI: 0.26, 0.73) for isoflavone intake. High intake of soy foods during adolescence was also associated with a reduced risk of premenopausal breast cancer (RR: 0.57; 95% CI: 0.34, 0.97). Women who consumed a high amount of soy foods consistently during adolescence and adulthood had a substantially reduced risk of breast cancer. No significant association with soy food consumption was found for postmenopausal breast cancer"
• Early soy intake may slash breast cancer risk later in life - Nutra USA, 3/30/09 - "By comparing the highest and lowest soy intake values for soy-based foods such as tofu, miso and natto, Korde and co-workers calculated that women with the highest soy intake during childhood (ages 5 to 11) had a 58 per cent lower risk of breast cancer as adults as the women with the lowest soy intake as children" - [Abstract]
• Childhood Soy Intake and Breast Cancer Risk in Asian American Women - Cancer Epidemiol Biomarkers Prev. 2009 Mar 24 - "Comparing highest with lowest tertiles, the multivariate relative risks (95% confidence interval) for childhood, adolescent, and adult soy intake were 0.40 (0.18-0.83; Ptrend = 0.03), 0.80 (0.59-1.08; Ptrend = 0.12), and 0.76 (0.56-1.02; Ptrend = 0.04), respectively"
• Soy consumption and prostate cancer risk in men: a revisit of a meta-analysis - Am J Clin Nutr. 2009 Feb 11 - "Our analysis of studies on soy intake yielded a combined RR/OR of 0.74"
• Soy phytochemicals decrease nonsmall cell lung cancer growth in female athymic mice - J Nutr. 2008 Jul;138(7):1360-4 - "soy phytochemicals slow the in vivo growth of NSCLC xenografts; the modulation of the Akt-signaling pathway observed in tumors of SSE-treated mice may have a role in the activity observed. Our research provides further support for the concept that consumption of phytoestrogens may be effective in delaying lung cancer progression"
• Breast development in the first 2 years of life: an association with soy-based infant formulas - J Pediatr Gastroenterol Nutr. 2008 Feb;46(2):191-5 - "We suggest that phytoestrogens impose a preserving effect on breast tissue that is evolved in early infancy, leading eventually to a slower waning of infantile breast tissue"
• Effect of a daily supplement of soy protein on body composition and insulin secretion in postmenopausal women - Fertil Steril. 2007 Dec;88(6):1609-17 - "A daily supplement of soy protein prevents the increase in subcutaneous and total abdominal fat observed with an isocaloric casein placebo in postmenopausal women"
• Legume and soy food intake and the incidence of type 2 diabetes in the Shanghai Women's Health Study - Am J Clin Nutr. 2008 Jan;87(1):162-7 - "The multivariate-adjusted relative risk of type 2 DM for the upper quintile compared with the lower quintile was 0.62 (95% CI: 0.51, 0.74) for total legumes and 0.53 (95% CI: 0.45, 0.62) for soybeans"
• Soy Consumption, Markers of Inflammation, and Endothelial Function: A cross-over study in postmenopausal women with the metabolic syndrome - Diabetes Care. 2007 Apr;30(4):967-73 - "Short-term soy nut consumption reduced some markers of inflammation and increased plasma nitric oxide levels in postmenopausal women with the metabolic syndrome"
• Soy inclusion in the diet improves features of the metabolic syndrome: a randomized crossover study in postmenopausal women - Am J Clin Nutr. 2007 Mar;85(3):735-41 - "Short-term soy-nut consumption improved glycemic control and lipid profiles in postmenopausal women with the metabolic syndrome"
• Dose effect of soy supplementation in prostate cancer: A pilot study - Oncol Rep. 2006 Dec;16(6):1221-4 - "With soy supplementation, serum testosterone levels decreased in 9 of 11 patients and estrogen levels decreased in 8 of 10 patients in a dose-dependent manner"
• Randomized, Double-Blind, Placebo-Controlled Crossover Study in Men with Prostate Cancer and Rising PSA: Effectiveness of a Dietary Supplement - Eur Urol. 2005 Oct 17 - "The supplement consisted of soy, isoflavones, lycopene, silymarin and antioxidants as main ingredients ... The soy-based dietary supplement utilised in this study was shown to delay PSA progression after potentially curative treatment in a significant fashion"
• Lipid-lowering effect of 2 dosages of a soy protein supplement in hypercholesterolemia - Adv Ther. 2005 Mar-Apr;22(2):175-86 - "either 15 or 25 g/d ... In the active treatment groups low-density lipoprotein cholesterol levels decreased significantly"
• Effects of a diet rich in phytoestrogens on prostate-specific antigen and sex hormones in men diagnosed with prostate cancer - Urology. 2004 Sep;64(3):510-5 - "Statistically significant differences were detected between the HT [heat-treated] soy grits group and the control wheat group for the percentage of change in total PSA (-12.7% versus 40% ... The data from this study indicate that a daily diet containing four slices of a bread rich in HT soy grits favorably influences the PSA level and the free/total PSA ratio in patients with prostate cancer"
• Isolated soy protein consumption reduces urinary albumin excretion and improves the serum lipid profile in men with type 2 diabetes mellitus and nephropathy - J Nutr. 2004 Aug;134(8):1874-80 - "isolated soy protein ... consumption led to changes of -9.5% in urinary albumin excretion (P < 0.0001), -0.45 in the total-to-HDL-cholesterol ratio (P < 0.05), -0.20 in the LDL-to-HDL cholesterol ratio (P < 0.05), and +4.3% in HDL cholesterol"
• Soy protein reduces triglyceride levels and triglyceride fatty acid fractional synthesis rate in hypercholesterolemic subjects - Atherosclerosis. 2004 Apr;173(2):269-75 - "Soy protein reduced TG by 12.4% ( [Formula: see text] ), total cholesterol by 4.4% ( [Formula: see text] ), and LDL cholesterol by 5.7% ( [Formula: see text] ) compared to animal protein"
• Inverse association of soy product intake with serum androgen and estrogen concentrations in Japanese men - Nutr Cancer 2000;36(1):14-8