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Recent Longevity News for the seven days ending 9/16/09.  You should consult your doctor if you are taking any medications.

FDA approves swine flu vaccine - USATODAY.com, 9/15/09 - "The bulk of vaccine will start arriving Oct. 15"

Swine Flu: How Long Are You Infectious? - WebMD, 9/15/09 - "On the eighth day after symptoms struck, 8% to 19% were still shedding live H1N1 virus ... The second study ... showed that 80% were still shedding virus after five days of illness, 40% at seven days, and 10% at 10 days"

Antioxidant Ingredient Proven To Relieve Stress - Science Daily, 9/14/09 - "The 35 people in our study who received capsules containing superoxide dismutase showed improvement in several signs and symptoms of perceived stress and fatigue" - See SOD products at iHerb.

On-the-job Pesticide Exposure Associated With Parkinson's Disease - Science Daily, 9/14/09 - "Among the patients with Parkinson's disease, 44 (8.5 percent) reported pesticide exposure compared with 27 (5.3 percent) of controls, such that occupational pesticide exposure was associated with an increased risk of the disease"

Diabetes Drug Fights Breast Cancer - WebMD, 9/14/09 - "And in mice carrying human breast cancers, metformin made standard chemotherapy vastly more effective. Mice treated with the combination remain cancer-free for four months, unlike mice treated with either drug alone ... A lot of data shows lower cancer risk -- not just breast cancer -- in people taking metformin for diabetes ... This drug at low doses can be considered a very good candidate for cancer prevention before a person has any cancer at all" - Note:  I've been taking metformin for years for anti-aging.  See my Insulin and Aging page.  See metformin at IAS.

High-Dose N-Acetylcysteine Reduces Contrast Nephropathy - Medscape, 9/14/09 - "the odds of contrast-induced nephropathy were 54% lower in patients randomized to high-dose N-acetylcysteine, compared to those randomized to a control group" - See n-acetyl cysteine at Amazon.com.

Daily Bathroom Showers May Deliver Face Full Of Pathogens, Says Study - Science Daily, 9/14/09 - "increases in pulmonary infections in the United States in recent decades from so-called "non-tuberculosis" mycobacteria species like M. avium may be linked to people taking more showers and fewer baths ... Water spurting from showerheads can distribute pathogen-filled droplets that suspend themselves in the air and can easily be inhaled into the deepest parts of the lungs ... Symptoms of pulmonary disease caused by M. avium can include tiredness, a persistent, dry cough, shortness of breath, weakness and "generally feeling bad," ... mmune-compromised people like pregnant women, the elderly and those who are fighting off other diseases are more prone to experience such symptoms ... plastic showerheads appear to "load up" with more pathogen-enriched biofilms, metal showerheads may be a good alternative"

Popular Stomach Acid Reducer Triples Risk Of Developing Pneumonia, Study Suggests - Science Daily, 9/14/09 - "hospitalized cardiothoracic surgery patients treated with pantoprazole were three times more likely to develop pneumonia"

The Many Causes Of Immune Deficiency - Science Daily, 9/14/09 - "Defects of the immune system lead to increased susceptibility to infection, autoimmune diseases (e.g. inflammatory rheumatism), allergies and sometimes even cancer ... The most common causes worldwide include malnutrition, poor sanitary conditions and human immune deficiency virus (HIV) infection. Other causes of temporary or permanent damage to the immune system include old age, medications (e.g. cortisone, cytostatic drugs), radiotherapy, stress after surgery and malignant tumors of the bone marrow and the lymph nodes"

Vaccine Expert Advises: Immunization Should Be Given As Early In Life As Possible - Science Daily, 9/14/09 - "Many parents would prefer to postpone the vaccination of their babies until these are older, by fear that their young immune system would be too weak or overwhelmed by the vaccines. In contrast, pediatricians insist that babies should be immunized as rapidly as possible after birth against the most dreadful microbes causing bacterial meningitis or whooping cough. These infections can cause irreversible damage or even kill the children"

Fish Intake in Maternal Diet, Mercury Exposure May Affect Fetal Growth - Medscape, 9/14/09 - "small for gestational age (SGA) ... Compared with mothers who consumed less than 1 portion of canned tuna per month, those consuming 2 or more portions per week had newborns who weighed more (P for trend = .03) and had a lower risk of having infants who were SGA for weight"

Early Data Show H1N1 Vaccine Is Highly Effective - Time, 9/10/09 - "The researchers calculate that every person infected by the virus will go onto infect another 1.3 to 1.7 people on average ... Preliminary data from the Australian trial showed that 21 days after getting one shot, 96% of the 240 trial volunteers aged 18 to 64 years generated an impressive amount of antibodies to the virus. The results were "unanticipated," according to the authors; health officials had expected that people would need two doses of the vaccine for full protection, because H1N1 is a new flu virus to most of the population ... The virus will be with us for many years to come in many forms ... It's important to start building up resistance now"

Vaccination Of 70 Percent Of US Population Could Control Swine Flu Pandemic - Science Daily, 9/10/09 - "An aggressive vaccination program that first targets children and ultimately reaches 70 percent of the U.S. population would mitigate pandemic influenza H1N1 that is expected this fall"

Note:  That’s something to think about. If you don’t get the flu shot you also hurting others by not containing the pandemic.  I’m not a doctor but here’s the way I understand it.  When you get the flu shot, what you are getting are dead viruses and your body builds immunity against that specific virus and a partial immunity against some similar viruses.  I’m sure that immunity decreases over the years but not completely.  Elderly that were exposed to the Swine virus as far back as 1918 are still partially immune (click here for the video).  A flu virus is most likely to be life threatening if it’s a virus totally different than anything you immune system has seen before.  So by getting the shot ever year, you decrease the chances of that happening.  Also, I read several years ago that the flu can cause permanent damage to organs such as the heart that can catch up to you later in life.

For people concerned about the mercury, some flu shots do have as much mercury as a small 6 ounce can of tuna.  Some argue that the form in the vaccine (ethylmercury in the thimerosal in vaccines) may be more lethal than the form in fish (methylmercury).   I don’t believe there have been any studies to prove or disprove that.  The form in the vaccine is eliminated from the body faster so it seems that it would have to be much more toxic to make up for that. There are flu vaccines with no or trace amounts of thimerosal.  There are vaccines that are mercury free (thimerosal, which is 49% 49% ethylmercury) free.  Thimerosal free vaccines are more expensive because they need to be packaged differently such as in single vials.  Click here for the list.  Click here for my web page on mercury in vaccines.

NNii : Immunization Science - National Network for Immunization Information - "Ethylmercury is much more rapidly excreted than methylmercury. Based upon the prevaccination blood levels in 6-months old infants, ethylmercury does not appear to accumulate after routine immunizations. Because samples also contained methylmercury, the measured blood levels may have overestimated the amount of ethylmercury present—but the levels were low in any case. Because 24-hour collections of stool were not tested, how much and how fast all of the administered ethylmercury is eliminated can not yet be estimated; it appears likely that most of the dose is rapidly excreted, however ... Because injected ethylmercury is much more rapidly excreted than methylmercury, exposure guidelines developed for the oral consumption of methylmercury were and are not accurate for the assessment of risk for infants who receive thimerosal-containing vaccines"

Back in the 50’s there were people who would not install seat belts because they heard of someone dying because they wore them even though the odds of dying by not wearing one was much greater, not even close. I see vaccines the same way. 36,000 people die each year of the flu. Last year was high at 57,000. That’s as much as the entire 10 years of the Vietnam War.

FDA Panel OKs HPV Vaccine Gardasil for Boys - WebMD, 9/9/09 - "An FDA advisory committee voted to recommend approval of the vaccine Gardasil for males ages 9 to 26 to prevent genital warts" - Note:  If I were younger I would use that as an excuse to use it off label as a precaution against head and neck cancer.  See:

  • Low Prevalence Of HPV Infection May Be Tied To Poor Prognosis For Blacks With Head And Neck Cancer - Science Daily, 7/29/09 - "Only 4 percent of black patients with squamous cell carcinoma in the study were HPV-positive, compared with 34 percent of white patients. The median overall survival was more than three-fold higher for whites (70.6 months) than for blacks (20.9 months) who were treated with chemotherapy and radiation. Dr. Cullen says the survival rate at five years for HPV-positive patients was about 85 percent, compared to 35 percent for HPV-negative patients. Survival was similar for HPV-negative patients, regardless of race. The study's findings confirm that HPV infection relates specifically to a type of head and neck cancer -- cancer of the oropharynx, which include the tonsils, soft palate and base of the tongue ... Overall, about 25 percent of head and neck cancers are tied to HPV infection"
  • Sharp Increase In HPV-positive Tonsil Cancer Found - Science Daily, 4/2/09 - "Because the tumours produce so few symptoms, patients seek medical care when the disease is relatively advanced, often after the tumours have spread to the lymph glands of the throat, possibly making the prognosis much worse ... More recent studies, however, have demonstrated a link between HPV and tonsil cancer, so that today an HPV infection is also one of the established risk factors ... Since 1970, the cumulative incidence of HPV-positive tonsil cancer has increased from 23 to 93 per cent"
  • ABC News: The Oral Sex Cancer Connection -  ABC News, 10/15/08 - "These are patients that are young. They are in their 30s and 40s. They are nonsmokers, and they don't drink alcohol ex ... There is absolutely a link between oral sex and oral cancer" - Click here for the 7 minute video.  I says that boys may want to get the HPV vaccine.
  • HPV-related oral cancers rise among younger men - baltimoresun.com, 4/14/08 - "They're men in their 40s, and even 30s, whose cancer is brought on by the increasingly common human papillomavirus (HPV) ... researchers now believe that the increase in certain oral cancers can be traced to the spread of the virus through oral sex ... New studies suggest that HPV-related oral cancer cases are on pace to eventually surpass cases of cervical cancer in the United States ... many doctors do not realize that they should be on the lookout for oral cancer in younger patients ... The public is unaware of this"
  • Incidence trends for human papillomavirus-related and -unrelated oral squamous cell carcinomas in the United States - J Clin Oncol. 2008 Feb 1;26(4):612-9 - "oral squamous cell carcinomas (OSCCs) ... Life-table analyses were used to compare 2-year overall survival for HPV-related and HPV-unrelated OSCCs. RESULTS: HPV-related OSCCs were diagnosed at younger ages than HPV-unrelated OSCCs (mean ages at diagnosis, 61.0 and 63.8 years, respectively; P < .001). Incidence increased significantly for HPV-related OSCC from 1973 to 2004 (annual percentage change [APC] = 0.80; P < .001), particularly among white men and at younger ages. By contrast, incidence for HPV-unrelated OSCC was stable through 1982 (APC = 0.82; P = .186) and declined significantly during 1983 to 2004 (APC = -1.85; P < .001). When treated with radiation, improvements in 2-year survival across calendar periods were more pronounced for HPV-related OSCCs (absolute increase in survival from 1973 through 1982 to 1993 through 2004 for localized, regional, and distant stages = 9.9%, 23.1%, and 18.6%, respectively) than HPV-unrelated OSCCs (5.6%, 3.1%, and 9.9%, respectively). During 1993 to 2004, for all stages treated with radiation, patients with HPV-related OSCCs had significantly higher survival rates than those with HPV-unrelated OSCCs"
  • Oral sex-related cancer at 30-year high - New Scientist, 2/28/08 - "The incidence of oral cancer due to a virus transmitted during oral sex has increased steeply over the last 30 years ... The rise was largest among young white males, suggesting this group is more likely to have oral sex at a younger age now than it was 20 years ago ... What is not in doubt, says Gillison, is the need to consider giving boys the HPV vaccine, to protect them from the disease ... These strains are also thought to cause oral cancer, as well as penile and anal cancer"
  • HPV-Related Oral Cancers on the Rise in Men - oncologystat.com, 2/2/08 - "The virus usually associated with cervical cancer has been linked to oral cancer in men, and is responsible for as many cases of the disease as tobacco and alcohol"
  • Human Papillomavirus in Cervical and Head-and-Neck Cancer - Medscape, 12/17/07 - "mounting epidemiological, molecular and clinical evidence indicates that high-risk HPVs (especially HPV.16) account for the development of headand-neck carcinoma in some individuals who do not have the classical risk factors for this disease (i.e. a history of tobacco use and/or alcohol consumption)"
  • Loud and clear on oral cancer - USATODAY.com, 11/25/07 - "The most likely culprit, he says: the same strains of human papillomavirus (HPV) that cause most cases of cervical cancer. A likely mode of transmission is oral sex"
  • Human Papilloma Virus Vaccines May Decrease Chances Of Oral Cancer - Science Daily, 8/30/07 - "oral and oropharyngeal squamous cell carcinoma (OOSCC) have been linked to high-risk HPV strains, the same strains that cause cervical cancer ... It's possible that oral and oropharyngeal cancers could be reduced if vaccination were more widespread; however, additional research is needed"
  • Oral Sex Implicated in Some Throat and Neck Cancers - washingtonpost.com, 8/27/07 - "Human papillomavirus (HPV), which is believed to be responsible for most cervical cancers, may also be at the root of many cancers of the mouth and throat ... Previous research has found that up to 50 percent of nonsmokers with throat and mouth cancers were infected with HPV"

Report Stirs Debate on Cell Phone Safety - WebMD, 9/9/09 - "studies are showing a 50% to 90% increased risk for two types of brain tumors -- gliomas and acoustic neuromas -- among people who have used cell phones for at least 10 years" - Click here to see how you cell phone rates.  The iPhone ranged from 0.52 to 1.19 W/kg, the lowest rated cell phone ranged 0.15 - 0.35 W/kg and the highest was 1.55 W/kg

New Role Of Vitamin C In Skin Protection; Relevance To The Cosmetics Industry - Science Daily, 9/8/09 - "a form of Vitamin C helped to promote wound healing and also helped protect the DNA damage of skin cells ... Previously, the group has published evidence that DNA repair is upregulated in people consuming vitamin C supplements ... The results demonstrated that vitamin C may improve wound healing by stimulating quiescent fibroblasts to divide and by promoting their migration into the wounded area. Vitamin C could also protect the skin by increasing the capacity of fibroblasts to repair potentially mutagenic DNA lesions ... Free radicals are associated with premature skin aging, and antioxidants, such as vitamin C, are known to counter these highly damaging compounds. This new evidence suggest that, in addition to ‘mopping up’ free radicals, vitamin C can help remove the DNA damage they form, if they get past the cell’s defences"

Abstracts from this week's Doctor's Guide Nutrition/Dietetics plus abstracts from my RSS feeds (Click here for the journals, the PubMed ones at the top):

Chronic periodontitis and the incidence of head and neck squamous cell carcinoma - Cancer Epidemiol Biomarkers Prev. 2009 Sep;18(9):2406-12 - "Patients with periodontitis were more likely to have poorly differentiated oral cavity SCC than those without periodontitis (32.8% versus 11.5%"

The pharmacodynamic equivalence of levothyroxine and liothyronine. A randomized, double blind, cross-over study in thyroidectomized patients - Clin Endocrinol (Oxf). 2009 Sep 10 - "The therapeutic substitution of L-T3 for L-T4 was achieved at approximately 1:3 ratio" - See T3 at International Anti-aging Systems.

A high normal TSH is associated with the metabolic syndrome - Clin Endocrinol (Oxf). 2009 Sep 10 - "Subjects with a TSH in the upper normal range (2.5 to 4.5 mU/l, n = 119) had a significantly higher BMI (30.47 +/- 0.57 vs. 28.74 +/- 0.18 kg/m(2), p = 0.001) and higher fasting triglycerides (1.583 +/- 0.082 vs. 1.422 +/- 0.024 mmol/l, p = 0.023), and their likeliness for fulfilling the criteria of the MS was 1.7-fold increased"

Iodine supplementation improves cognition in mildly iodine-deficient children - Am J Clin Nutr. 2009 Sep 2 - "The overall cognitive score of the iodine-supplemented group was 0.19 SDs higher than that of the placebo group ... Iodine supplementation improved perceptual reasoning in mildly iodine deficient children and suggests that mild iodine deficiency could prevent children from attaining their full intellectual potential"

Coffee and tea consumption and risk of type 2 diabetes - Diabetologia. 2009 Sep 1 - "After adjustment for potential confounders, coffee and tea consumption were both inversely associated with type 2 diabetes, with hazard ratios of 0.77 (95% CI 0.63-0.95) for 4.1-6.0 cups of coffee per day (p for trend = 0.033) and 0.63 (95% CI: 0.47-0.86) for >5.0 cups of tea per day (p for trend = 0.002). Total daily consumption of at least three cups of coffee and/or tea reduced the risk of type 2 diabetes by approximately 42%"

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