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Home > Anti-aging Research > Pectin

Pectin

Specific Recommendations:

News & Research:

  • Apple fibres may boost immune health: Study - Nutra USA, 3/3/10 - "fed low-fat diets supplemented with either soluble (pectin, 10 per cent of the diet) or insoluble fibre (cellulose, 5 or 10 per cent of the diet) for six weeks. At the end of this period the mice were challenged with an endotoxin to induce sickness ... Two hours after [entotoxin] injection, the mice fed soluble fibre were only half as sick as the other group, and they recovered 50 per cent sooner. And the differences between the groups continued to be pronounced all the way out to 24 hours" - [Abstract] [Science Daily]
  • Pectin Power: Why Fruits And Vegetables May Protect Against Cancer's Spread - Science Daily, 10/13/08 - "They have shown that a fragment released from pectin, found in all fruits and vegetables, binds to and is believed to inhibit galectin 3 (Gal3), a protein that plays a role in all stages of cancer progression"
  • Pectin shows potential against prostate cancer - Nutra USA, 8/22/07 - "The new study looked at the effect of different forms of pectin - commercially available fractionated pectin powder (FPP), citrus pectin (CP), and pH-modified CP (PectaSol) - on hormone- (androgen) responsive and androgen-independent human prostate cancer cells ... the FPP induced apoptosis (programmed cell death) by about 40 fold, compared to non-treated cells, for both types of cancer cell"  - [Abstract]
  • Citrus Nutrient Helps Slow Prostate Cancer - WebMD, 12/16/03 - "Every day, patients took 18 capsules of pectin: Each contained 14 grams of pectin, equaling 800 mg a day ... Fourteen months later, 70% of the men had significant increases in the time it took to produce PSA -- it took longer for prostate cells to produce a doubling of blood PSA levels"

Abstracts:

  • Pectins that Structurally Differ in the Distribution of Methyl-esters Attenuate Citrobacter rodentium-Induced Colitis - Mol Nutr Food Res 2021 Aug 9 - "Pectins have anti-inflammatory properties on intestinal immunity through direct interactions on Toll-like receptors (TLRs) in the small intestine or via stimulating microbiota-dependent effects in the large intestine. Both the degree of methyl-esterification (DM) and the distribution of methyl-esters (degree of blockiness; DB) of pectins contribute to this influence on immunity but whether and how the DB impacts immunity through microbiota-dependent effects in the large intestine is unknown ... Pectins prevent C. rodentium-induced colonic inflammation by lowering the C. rodentium load in the caecum independently of the DB" - See pectin supplements at Amazon.com.
  • Pectic Oligogalacturonide Facilitates the Synthesis and Activation of Adiponectin to Improve Hepatic Lipid Oxidation - Mol Nutr Food Res 2021 Jul 15 - "Adiponectin (ADPN), a kind of adipokines, plays an important role in the regulation of lipid metabolism ... POS can act as an ADPN activator to improve lipid metabolism, leading it to the applications of biomedical and functional foods for ameliorating chronic liver diseases resulted from a high-energy diet"
  • Dietary Pectin Regulates the Levels of Inflammatory Cytokines and Immunoglobulins in Interleukin-10 Knockout Mice - J Agric Food Chem. 2010 Oct 14 - "Pectin has protective, anti-inflammatory effects on inflammatory bowel disease (IBD), but the exact mechanism is unknown ... Pectin treatment reduced expression of TNF-α and GATA-3, an important transcription factor for the Th2 immune response. These mice also expressed lower levels of IgE in the spleen and Peyer's patches (PP) and lower IgG and IgM expression in PP. Interestingly, IL-10 deficiency resulted in lower CD4(+) and CD8(+) populations in the spleen, mesenteric lymph node (MLN), and PP; however, pectin counteracted these declines in the MLN and PP. Therefore, dietary pectin downregulates the inflammatory response in the colon by moderating the production of proinflammatory cytokines and immunoglobulins"
  • Sickness behavior induced by endotoxin can be mitigated by the dietary soluble fiber, pectin, through up-regulation of IL-4 and Th2 polarization - Brain Behav Immun. 2010 Feb 6 - "We show that a diet rich in soluble fiber protects mice from endotoxin-induced sickness behavior by polarizing mice Th2 when compared to a diet containing only insoluble fiber. Mice fed soluble fiber became less sick and recovered faster from endotoxin-induced sickness behaviors than mice fed insoluble fiber ... These data show that a diet rich in soluble fiber protects against endotoxin-induced sickness behavior by polarizing mice Th2 and promoting alternative activation of macrophages" - See pectin supplements at Amazon.com.