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Recent Longevity News for the seven days ending 3/28/12.  You should consult your doctor if you are taking any medications.

Salivary Testing for Periodontal Disease - Medscape, 3/26/12 - "Salivary samples were sent to the laboratory for a DNA-polymerase chain reaction (PCR) test (My Perio Path®; OralDNA Labs; Brentwood, Tennessee) to test for the presence of high-risk pathogens and a periodontal susceptibility test (PST®, OralDNA Labs, Brentwood, Tennessee) for the probability of more severe periodontal disease. The DNA bacteria test identifies the type and concentration of pathogenic bacteria that are known to cause periodontal disease. The PST detects variations in the genes for interleukin 1A and 1B that suggest a predisposition for overexpression of inflammation and risk for periodontal disease. These tests permit appropriate treatment of the patient's periodontal disease, without overtreating or undertreating, and take the level of risk for future disease and complications into consideration ... All of these pathogens are associated with periodontal disease. Aa leukotoxin kills white blood cells in a variety of ways, allowing pathogenic bacteria to survive the immune response and releasing compounds that are essential for bacteria survival and growth. Aa leukotoxin is involved in attachment loss in adolescents, indicating that it plays a role in the pathogenesis of aggressive periodontitis ... Specific home care instructions: Use a power toothbrush ... Use a water irrigator ... Use antibacterial tooth paste ... Use antibacterial mouth rinse ... Eat a balanced diet high in antioxidants ... Take high-quality nutritional supplementation ... Get adequate rest and exercise ... adjunct to treatment based on the patient's bacterial profile: amoxicillin 500 mg 3 times daily for 8 days and metronidazole 500 mg twice daily for 8 days beginning on the last day of periodontal therapy ... Taking into consideration the transmissible nature of Aa, the odds that his wife has a similar periodontal pathogen profile are substantial"

Packing on the Pounds - The Daily, 3/26/12 - "The claims by leading BPA critic Frederick vom Saal come as the Food and Drug Administration is expected to rule this week — after four years of study — on whether to ban the plastic additive from use in food packaging ... Vom Saal told The Daily he will soon release a new study showing that mothers who expose their fetuses to the bisphenol A run the risk of having obese children ... BPA turns out to be a major factor in the number of fat cells that a person will have later in life ... over the past few months, a slew of new research has focused on the BPA-obesity link. Vom Saal’s findings are just the latest new evidence that BPA may be playing a role in the global obesity epidemic. Another study released in February by a Spanish research team showed that even small amounts of BPA cause human adult islet cells to produce more fat in the body ... It takes 90 days under the Toxic Substances Control Act to get a chemical approved for sale on the market ... Getting a product off the market that has been shown to be unsafe, on the other hand, takes somewhere between 25 and 50 years, because industry says we need definitive science"

Metformin Associated With Lower Cancer Risk - Medscape, 3/26/12 - "During up to 10 years of follow-up, metformin users were less likely to receive cancer diagnoses than sulfonylurea users (hazard ratio, 0.9; 95% confidence interval, 0.88–0.91) after adjustment for age, sex, and several other variables. This 10% reduction was modest in relative terms but highly statistically significant. Metformin-associated lower risks were noted for cancers of the esophagus, stomach, colon, liver, pancreas, lung, breast, and prostate ... If hyperinsulinemia really does promote cancer, metformin theoretically could lower cancer risk in type 2 diabetic patients because it lowers circulating glucose and insulin levels in patients with insulin resistance and hyperinsulinemia"

Diabetes drug can prevent heart disease, new study suggests - Science Daily, 3/25/12 - "one of the most common diabetes drugs, metformin, also has a protective effect on the heart ... metformin helps increase pumping capacity, improve energy balance, reduce the accumulation of fat, and limit the loss of heart cells through programmed cell death" - See metformin at The Antiaging Store.

Low Levels of LDL Cholesterol Predate Cancer Cases - Medscape, 3/25/12 - "there is nothing here to suggest that statins would be unsafe"

Brain insulin resistance contributes to cognitive decline in Alzheimer's disease - Science Daily, 3/23/12 - "This is the first study to directly demonstrate that insulin resistance occurs in the brains of people with Alzheimer's disease ... Our research clearly shows that the brain's ability to respond to insulin, which is important for normal brain function, is going offline at some point ... We believe that brain insulin resistance may be an important contributor to the cognitive decline associated with Alzheimer's disease ... The risk of developing Alzheimer's disease is increased by 50 percent in people with diabetes ... insulin resistance of the brain occurs in Alzheimer's disease independent of whether someone has diabetes ... The investigators used samples of postmortem brain tissue from non-diabetics who had died with Alzheimer's disease, stimulated the tissue with insulin, and measured how much the insulin activated various proteins in the insulin-signaling pathways ... three insulin-sensitizing medicines are already approved by the FDA for treatment of diabetes. These drugs readily cross the blood-brain barrier and may have therapeutic potential to correct insulin resistance in Alzheimer's disease and MCI" - Note:  I suspected this for a long time.  It doesn't say what those three drugs are but I'm guessing metformin and Actos are two of them.  I don't have diabetes but I take low doses of both.  My doc says I'm crazy.  See metformin and pioglitazone (Actos) at OffshoreRx1.com.

More Evidence That ARBs Have Cognitive Benefits - Medscape, 3/23/12 - "After stopping their antihypertensive medications, the patients were randomly assigned to the ARB candesartan (n = 20), the angiotensin-converting enzyme inhibitor (ACEI) lisinopril (n = 18), or the diuretic hydrochlorothiazide (n = 15) ... After adjustment for age and baseline score on the Mini-Mental State Examination, patients taking candesartan showed the greatest improvements on tests assessing executive function ... Our findings further support observational data showing that ARB use is associated with lower risk of dementia and Alzheimer disease compared with the use of ACEIs or other antihypertensives ... As reported previously by Medscape Medical News, Dr. Kehoe and colleagues recently published a study showing a 53% lower risk for Alzheimer's disease in older adults prescribed an ARB compared with those prescribed other antihypertensive agents"

Bald-breaker! - The Daily, 3/22/12 - "the protein prostaglandin D2 was found at triple the level in the bald patches of skin in both men and male mice ... when added to a single hair in a lab dish, the protein bound itself to the hair’s cells and stunted its growth ... Over the next two years, there’ll very likely be a product based on prostaglandins to treat hair loss"

Asthma: Low Vitamin D Linked to High IgE, Need for Steroids - Medscape, 3/22/12 - "We suggest that supplementation with vitamin D should be done in patients with asthma, both adults and children, to lower steroid requirement and improve steroid response" - See vitamin D at Amazon.com.

Bottled water may boost kids' tooth decay, dentists say - MSNBC, 3/20/12 - "the practice of skipping tap water in favor of bottled water may be contributing to rising rates of tooth decay in young children ... You should brush twice a day with a fluoride toothpaste ... bottled water may not have a sufficient amount of fluoride, which is important for preventing tooth decay and promoting oral health" - See 1.1% sodium fluoride toothpaste at Amazon.com.

Daily Aspirin May Help Prevent and Treat Cancer - WebMD, 3/20/12 - "analyzed data from 51 trials originally designed to examine the impact of daily aspirin on heart attack and stroke risk ... taking a low-dose aspirin every day reduced the risk of death from cancer by 37% after at least five years of use ... In a second study, the researchers examined the impact of daily aspirin therapy on cancer metastasis, or spread, by analyzing newly published data from five other large trials ... Over an average follow-up of six-and-a-half years, daily aspirin use was associated with a 36% reduced risk of cancer with distant spread"

Feeding your baby on demand 'may contribute to higher IQ' - Science Daily, 3/20/12 - "demand-feeding is associated with higher IQ scores at age eight, and this difference is also evident in the results of SATs tests at ages five, seven, 11 and 14 ... The difference in IQ levels of around four to five points, though statistically highly significant, would not make a child at the bottom of the class move to the top, but it would be noticeable"

Bisphenol A (BPA) could affect reproductive capabilities, cause infection of the uterus - Science Daily, 3/20/12 - "in addition to affecting the heart, brain and nervous system, bisphenol A (BPA), could affect a mammal's ability to reproduce by altering the structure of the uterus in ways that can progress to a potentially fatal infection ... These results suggest that BPA enhances the immune responsiveness of the uterus and that the heightened responsiveness in the C57BL/6 strain of females is related to increased susceptibility to pyometra"

Abstracts from this week's Doctor's Guide Nutrition/Dietetics plus abstracts from my RSS feeds (Click here for the journals, the PubMed ones at the top):

Protection of LDL from oxidation by olive oil polyphenols is associated with a downregulation of CD40-ligand expression and its downstream products in vivo in humans - Am J Clin Nutr. 2012 Mar 21 - "Polyphenols could exert health benefits not only by scavenging free radicals but also by modulating gene expression ... a randomized, crossover, controlled trial, 18 healthy European volunteers daily received 25 mL olive oil with a low polyphenol content (LPC: 2.7 mg/kg) or a high polyphenol content (HPC: 366 mg/kg) in intervention periods of 3 wk separated by 2-wk washout periods ... In addition to reducing LDL oxidation, the intake of polyphenol-rich olive oil reduces CD40L gene expression, its downstream products, and related genes involved in atherogenic and inflammatory processes in vivo in humans. These findings provide evidence that polyphenol-rich olive oil can act through molecular mechanisms to provide cardiovascular health benefits" - See olive leaf extract at Amazon.com.

Low Serum 25-Hydroxyvitamin D Is Associated with Increased Risk of the Development of the Metabolic Syndrome at Five Years: Results from a National, Population-Based Prospective Study - J Clin Endocrinol Metab. 2012 Mar 22 - "metabolic syndrome (MetS) ... waist circumference (WC) ... Compared with those in the highest quintile of 25(OH)D (≥34 ng/ml), MetS risk was significantly higher in people with 25(OH)D in the first (<18 ng/ml) and second (18-23 ng/ml) quintiles; odds ratio (95% confidence interval) = 1.41 (1.02-1.95) and 1.74 (1.28-2.37), respectively. Serum 25(OH)D was inversely associated with 5-yr WC (P < 0.001), triglycerides (P < 0.01), fasting glucose (P < 0.01), and homeostasis model assessment for insulin resistance (P < 0.001) but not with 2-h plasma glucose (P = 0.29), high-density lipoprotein cholesterol (P = 0.70), or blood pressure (P = 0.46).Conclusions:In Australian adults, lower 25(OH)D concentrations were associated with increased MetS risk and higher WC, serum triglyceride, fasting glucose, and insulin resistance at 5 yr" - See vitamin D at Amazon.com.

A Combination of High-dose Vitamin C Plus Zinc for the Common Cold - J Int Med Res. 2012;40(1):28-42 - "Vitamin C and zinc play important roles in nutrition, immune defence and maintenance of health. Intake of both is often inadequate, even in affluent populations ... After an overview of the literature on the effects of the separate administration of either vitamin C or zinc against the common cold, this article presents data from two preliminary, double-blind, randomized, placebo-controlled trials, conducted with a combination of 1000 mg vitamin C plus 10 mg zinc in patients with the common cold. In both studies, a nonsignificant reduction of rhinorrhoea duration (range 9 - 27%) was seen. In pooled analyses of both studies (n = 94), vitamin C plus zinc was significantly more efficient than placebo at reducing rhinorrhoea over 5 days of treatment. Furthermore, symptom relief was quicker and the product was well tolerated"

Health Focus (Alzheimer's Disease):

Popular Supplements:

Alternative News:

  • Scientists pinpoint how vitamin D may help clear amyloid plaques found in Alzheimer's - Science Daily, 3/6/12 - "vitamin D3 may activate key genes and cellular signaling networks to help stimulate the immune system to clear the amyloid-beta protein ... in both Type I and Type II macrophages, the added 1a,25-dihydroxyvitamin D3 played a key role in opening a specific chloride channel called "chloride channel 3 (CLC3)," which is important in supporting the uptake of amyloid beta through the process known as phagocytosis. Curcuminoids activated this chloride channel only in Type I macrophages ... The scientists also found that 1a,25-dihydroxyvitamin D3 strongly helped trigger the genetic transcription of the chloride channel and the receptor for 1a,25-dihydroxyvitamin D3 in Type II macrophages" - See vitamin D at Amazon.com.
  • Omega-3 Fatty Acids Help Brain Age Better - WebMD, 2/27/12 - "the results suggest diets lacking in omega-3 fatty acids may cause the brain to age faster ... people whose DHA levels were in the bottom 25% of the group had lower brain volumes compared with people with higher DHA levels ... In addition, people with both low DHA and all the other omega-3 fatty acid levels scored lower on tests of visual memory, processing, and abstract thinking ... Researchers say the results suggest that low DHA and other omega-3 fatty acid levels are associated with a pattern of memory and brain function problems even in people free of dementia" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
  • Mediterranean Diet May Protect Brain - WebMD, 2/13/12 - "white matter hyperintensity volume (WMHV) ... WMHV is an indicator of small blood vessel damage in the brain and is detected by magnetic resonance screening (MRI) ... researchers compared the brain scans and diets of 966 adults with an average age of 72 ... those who most closely followed a Mediterranean diet had a lower measure of WMHV than those who did not. Each increase in the Mediterranean diet score was associated with a corresponding decrease in white matter hyperintensity volume score ... the aspect of the Mediterranean diet that seemed to matter most was the ratio of monounsaturated fat to saturated fat"
  • More vitamin E linked to better mental function: Study - Nutra USA, 1/11/12 - "Alzheimer patients were 85% less likely to have the highest levels of vitamin E, compared with people with normal cognitive function ... There are eight forms of vitamin E: four tocopherols (alpha, beta, gamma, delta) and four tocotrienols (alpha, beta, gamma, delta) ... the new study is said to be the first to evaluate all the forms of vitamin E in relation to Alzheimer’s disease ... Consumers should be taking a full spectrum vitamin E especially for improving/ preserving cognitive health and performance" - [Abstract] - See Jarrow FamilE (contains all eight members of the vitamin E family, includes Tocomin) at Amazon.com.
  • Alzheimer's: Diet patterns may keep brain from shrinking - Science Daily, 12/29/11 - "People with diets high in several vitamins or in omega 3 fatty acids are less likely to have the brain shrinkage associated with Alzheimer's disease than people whose diets are not high in those nutrients ... Those with diets high in omega 3 fatty acids and in vitamins C, D, E and the B vitamins also had higher scores on mental thinking tests than people with diets low in those nutrients ... people with diets high in trans fats were more likely to have brain shrinkage and lower scores on the thinking and memory tests than people with diets low in trans fats" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
  • Antioxidant has potential in the Alzheimer's fight - Science Daily, 12/14/11 - "When you cut an apple and leave it out, it turns brown. Squeeze the apple with lemon juice, an antioxidant, and the process slows down ... Simply put, that same "browning" process-known as oxidative stress-happens in the brain as Alzheimer's disease sets in ... an antioxidant can delay the onset of all the indicators of Alzheimer's disease, including cognitive decline. The researchers administered an antioxidant compound called MitoQ to mice genetically engineered to develop Alzheimer's. The results of their study were published in the Nov. 2 issue of the Journal of Neuroscience ... Oxidative stress is believed to cause neurons in the brain to die, resulting in Alzheimer's ... The brain consumes 20 percent of the oxygen in the body even though it only makes up 5 percent of the volume, so it's particularly susceptible to oxidative stress ... MitoQ selectively accumulates in the mitochondria" - Note:  I couldn't find the ingredients but it sounds like a form of co-enzyme Q10.  Here's the form I take: ubiquinol products at Amazon.com
  • Eating fish reduces risk of Alzheimer's disease - Science Daily, 11/30/11 - "This is the first study to establish a direct relationship between fish consumption, brain structure and Alzheimer's risk ... people who consumed baked or broiled fish at least one time per week had better preservation of gray matter volume on MRI in brain areas at risk for Alzheimer's disease ... Each patient underwent 3-D volumetric MRI of the brain. Voxel-based morphometry, a brain mapping technique that measures gray matter volume, was used to model the relationship between weekly fish consumption at baseline and brain structure 10 years later ... consumption of baked or broiled fish on a weekly basis was positively associated with gray matter volumes in several areas of the brain. Greater hippocampal, posterior cingulate and orbital frontal cortex volumes in relation to fish consumption reduced the risk for five-year decline to MCI or Alzheimer's by almost five-fold ... Consuming baked or broiled fish promotes stronger neurons in the brain's gray matter by making them larger and health"
  • B vitamins may slow cognitive decline: Oxford University study - Nutra USA, 10/25/11 - "A daily combination of folic acid, and vitamins B6 and B12 was associated with a 30% reduction in levels of the amino acid homocysteine, and improvements in a range of mental tests, including global cognition and episodic memory ... One interpretation [of the data] is that lowering homocysteine concentrations by administering B vitamins slows brain atrophy, which in turn slows both cognitive and clinical decline ... The Vitacog study involved 266 people over the age of 70 with diagnosed mild cognitive impairment. Participants were randomly assigned to receive either placebo or a B vitamin supplement providing 0.8 mg per day of folic acid, 0.5 mg of vitamin B12 and 20 mg of vitamin B6" - [Abstract]
  • Vitamin B12, cognition, and brain MRI measures: A cross-sectional examination - Neurology. 2011 Sep 27;77(13):1276-82 - "Concentrations of all vitamin B12-related markers, but not serum vitamin B12 itself, were associated with global cognitive function and with total brain volume. Methylmalonate levels were associated with poorer episodic memory and perceptual speed, and cystathionine and 2-methylcitrate with poorer episodic and semantic memory. Homocysteine concentrations were associated with decreased total brain volume. The homocysteine-global cognition effect was modified and no longer statistically significant with adjustment for white matter volume or cerebral infarcts. The methylmalonate-global cognition effect was modified and no longer significant with adjustment for total brain volume ... Methylmalonate, a specific marker of B12 deficiency, may affect cognition by reducing total brain volume whereas the effect of homocysteine (nonspecific to vitamin B12 deficiency) on cognitive performance may be mediated through increased white matter hyperintensity and cerebral infarcts. Vitamin B12 status may affect the brain through multiple mechanisms" - See vitamin B12 at Amazon.com.
  • Low vitamin B12 levels may lead to brain shrinkage, cognitive problems - Science Daily, 9/26/11 - "Older people with low blood levels of vitamin B12 markers may be more likely to have lower brain volumes and have problems with their thinking skills ... An average of four-and-a-half years later, MRI scans of the participants' brains were taken to measure total brain volume and look for other signs of brain damage ... Having high levels of four of five markers for vitamin B12 deficiency was associated with having lower scores on the cognitive tests and smaller total brain volume ... On the cognitive tests, the scores ranged from -2.18 to 1.42, with an average of 0.23. For each increase of one micromole per liter of homocysteine -- one of the markers of B12 deficiency -- the cognitive scores decreasedby 0.03 standardized units or points" - See vitamin B12 at Amazon.com.
  • Omega-3 may ease depression symptoms, slash dementia risk: RCT - Nutra USA, 9/23/11 - "recruited 50 people over the age of 65 to participate in their six-month double-blind, randomized controlled trial ... Participants received daily supplements of EPA- or DHA-rich fish oil, or the omega-6 linoleic acid (LA, 2.2 grams per day). The EPA-rich supplement provided 1.67 grams of EPA and 0.16 grams of DHA, while the DHA-rich supplement provided 1.55 grams of DHA and 0.40 grams of EPA ... compared with the group receiving the LA supplements, the EPA-rich supplement group displayed higher scores on the Geriatric Depression Scale ... On the other hand, the DHA group displayed improvements in verbal fluency ... These results indicate that DHA-rich and EPA-rich fish oils may be effective for depressive symptoms and health parameters, exerting variable effects on cognitive and physical outcomes" - [Abstract] - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
  • Aerobic exercise may reduce the risk of dementia, researchers say - Science Daily, 9/7/11 - "Researchers examined the role of aerobic exercise in preserving cognitive abilities and concluded that it should not be overlooked as an important therapy against dementia ... Examples include walking, gym workouts and activities at home such as shoveling snow or raking leaves ... We culled through all the scientific literature we could find on the subject of exercise and cognition, including animal studies and observational studies, reviewing over 1,600 papers, with 130 bearing directly on this issue ... brain imaging studies have consistently revealed objective evidence of favorable effects of exercise on human brain integrity"
  • Natural Alzheimer's-fighting compound created inexpensively in lab - Science Daily, 8/25/11 - "Until now, researchers have only been able to derive small amounts of the compound directly from the Huperzia serrata plant, or had to resort to lengthy and cumbersome methods to synthesize it in the lab ... Now researchers at Yale have developed a practical and cost-effective method to synthesize huperzine A in the lab. The process requires just eight steps and produces a yield of 40 percent. Previously, the best synthetic techniques had required twice as many steps and achieved yields of only two percent ... In addition, the Herzon lab and the firm are working with the U.S. Army, which is interested in huperzine A's potential in blocking the effects of chemical warfare agents ... Other Alzheimer's treatments based on enzyme inhibitors are currently prescribed in the U.S., but huperzine A binds better, is more easily absorbed by the body and last longer in the body than other treatments ... We believe huperzine A has the potential to treat a range of neurologic disorders more effectively than the current options available" - See huperzine at Amazon.com.
  • Treatment with vitamin C dissolves toxic protein aggregates in Alzheimer's disease - Science Daily, 8/18/11 - "The brains of people with Alzheimer's disease contain lumps of so-called amyloid plaques which consist of misfolded protein aggregates. They cause nerve cell death in the brain and the first nerves to be attacked are the ones in the brain's memory centre ... When we treated brain tissue from mice suffering from Alzheimer's disease with vitamin C, we could see that the toxic protein aggregates were dissolved ... The notion that vitamin C can have a positive effect on Alzheimer's disease is controversial, but our results open up new opportunities for research into Alzheimer's and the possibilities offered by vitamin C" - See Garden of Life, Vitamin Code, Raw Vitamin C, 60 UltraZorbe Veggie Caps at iHerb.
  • Fish oil's impact on cognition and brain structure identified in new study - Science Daily, 8/17/11 - "Researchers at Rhode Island Hospital's Alzheimer's Disease and Memory Disorders Center have found positive associations between fish oil supplements and cognitive functioning as well as differences in brain structure between users and non-users of fish oil supplements ... compared to non-users, use of fish oil supplements was associated with better cognitive functioning during the study. However, this association was significant only in those individuals who had a normal baseline cognitive function and in individuals who tested negative for a genetic risk factor for Alzheimer's Disease known as APOE4. This is consistent with previous research ... The unique finding, however, is that there was a clear association between fish oil supplements and brain volume ... In other words, fish oil use was associated with less brain shrinkage in patients taking these supplements during the ADNI study compared to those who didn't report using them" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
  • Natural chemical found in grapes may protect against Alzheimer's disease - Science Daily, 7/16/11 - "grape seed polyphenols -- a natural antioxidant -- may help prevent the development or delay the progression of Alzheimer's disease ... This is the first study to evaluate the ability of grape-derived polyphenols to prevent the generation of a specific form of β-amyloid (Aβ) peptide, a substance in the brain long known to cause the neurotoxicity associated with Alzheimer disease ... administered grape seed polyphenolic extracts to mice genetically determined to develop memory deficits and Aβ neurotoxins similar to those found in Alzheimer's disease. They found that the brain content of the Aβ*56, a specific form of Aβ previously implicated in the promotion of Alzheimer's disease memory loss, was substantially reduced after treatment" - See grape seed extract at Amazon.com.
  • The Body Odd - Coffee buzz protects brain from Alzheimer's - MSNBC, 6/29/11 - "the equivalent of four to five cups of caffeinated coffee every few days led to much improved memories in the Alzheimer’s mice ... Earlier research by Arendash and his colleagues showed that caffeine could at least partially block the production of beta amyloid, the sticky protein that clogs the brains of Alzheimer’s patients. They also found that a substance called granulocyte-colony stimulating factor, or GCSF, sparked the production of new axons, the communication cables that link nerve cells together, as well as new nerve cells themselves"
  • Lithium profoundly prevents brain damage associated with Parkinson's disease, mouse study suggests - Science Daily, 6/24/11 - "lithium has recently been suggested to be neuroprotective in relation to several neurodegenerative conditions including Alzheimer's disease, Huntington's disease and amyotrophic lateral sclerosis and has been touted for its anti-aging properties in simple animals" - See lithium supplements at Amazon.com.
  • Nutritional Supplement Boosts Cognition in Healthy Women - Medscape, 6/21/11 - "Citicoline, a naturally occurring substance found in the brain and liver and marketed as a nutritional supplement, enhanced aspects of cognition in healthy women and may have a role in mitigating the cognitive decline associated with normal aging ... It may also improve the attention deficits associated with psychiatric disorders ... The women were divided into 3 groups of 20 and randomly assigned to receive a daily oral citicoline dose of 250 mg (low dose) or 500 mg (high dose) or placebo for 28 days ... participants who received low- or high-dose citicoline showed improved attention, demonstrating fewer commission and omission errors on the CPT-II compared with the placebo group" - See citicholine at Amazon.com.
  • Mystery ingredient in coffee boosts protection against Alzheimer's disease - Science Daily, 6/21/11 - "A yet unidentified component of coffee interacts with the beverage's caffeine, which could be a surprising reason why daily coffee intake protects against Alzheimer's disease. A new Alzheimer's mouse study by researchers at the University of South Florida found that this interaction boosts blood levels of a critical growth factor that seems to fight off the Alzheimer's disease process ... The new study does not diminish the importance of caffeine to protect against Alzheimer's. Rather it shows that caffeinated coffee induces an increase in blood levels of a growth factor called GCSF (granulocyte colony stimulating factor). GCSF is a substance greatly decreased in patients with Alzheimer's disease and demonstrated to improve memory in Alzheimer's mice ... The boost in GCSF levels is important, because the researchers also reported that long-term treatment with coffee (but not decaffeinated coffee) enhances memory in Alzheimer's mice. Higher blood GCSF levels due to coffee intake were associated with better memory ... First, GCSF recruits stem cells from bone marrow to enter the brain and remove the harmful beta-amyloid protein that initiates the disease. GCSF also creates new connections between brain cells and increases the birth of new neurons in the brain ... An increasing body of scientific literature indicates that moderate consumption of coffee decreases the risk of several diseases of aging, including Parkinson's disease, Type II diabetes and stroke"
  • Fatty Acids and Cognitive Decline in Women - Medscape, 6/13/11 - "In this cohort of older women, greater MUFA intake was associated with less cognitive decline over a 3-year period. Previous studies generally but not invariably support this association. One previous prospective study found greater dietary MUFA intake to be associated with less cognitive decline,[10] a second found a trend in the same direction,[9] a third found a trend in the same direction in restricted analyses,[6] and three others were null.[7,8,11] None of the null studies had multiple measures of diet; one assessed diet using a measure of fatty acid composition of erythrocyte membranes,[7] but that study assessed cognitive decline exclusively using the Mini-Mental State Examination, which is probably not as sensitive as the neuropsychological test battery used in this study ... MUFA is thought to be one of the major protective components of the traditional Mediterranean diet, in which it is derived primarily from olive oil (median 46 g/d).[10] Two recent prospective studies of the Mediterranean diet have found greater adherence to be associated with less cognitive decline and lower incidence of Alzheimer's disease (AD).[31,32] One of these studies found an effect of the Mediterranean diet on an individual cognitive domain, namely memory.[31] This finding is consistent with the observed protective effect of MUFA on memory in the WHI CCW. In addition, the current study found an association between MUFA and less decline in visual–spatial abilities (copying and matching), a finding not previously made to the knowledge of the authors of the current study. Decline in visuospatial function has been associated with driving errors in older adults[33] and has also been suggested as a potential predictor (along with amnestic impairment) of transition from mild cognitive impairment to AD ... Several pathways may explain the apparent relationship between MUFA intake and cognitive function. MUFA and MUFA derivatives have antiinflammatory effects in vivo,[35,36] which may be important because chronic inflammation appears to be a precursor of symptomatic AD.[37–39] Oxidative stress has also been demonstrated in patients with mild cognitive impairment and AD,[40] and derivatives from MUFA, including low-molecular-weight phenols, have been found to have antioxidant effects.[41] MUFA may also exert their potentially beneficial effects on cognition indirectly by decreasing cardiovascular risk by reducing macrophage uptake of plasma oxidized low-density lipoprotein, apolipoprotein B, and f triglycerides" - Click here for my olive oil mayonnaise recipe.
  • Naturally occurring plant alkaloids could slow down Alzheimer's disease, study suggests - Science Daily, 5/26/11 - "Beta-carboline alkaloids could potentially be used in therapeutic drugs to stop, or at least slow down, the progressively debilitating effects of Alzheimer's ... Beta-carboline alkaloids are found in a number of medicinal plants. They have antioxidant properties, and have been shown to protect brain cells from excessive stimulation of neurotransmitters. "(They) are natural occurring compounds in some plant species that affect multiple central nervous system targets,""
  • Moderate exercise dramatically improves brain blood flow in elderly women - Science Daily, 4/12/11 - "it's never too late for women to reap the benefits of moderate aerobic exercise. In a 3-month study of 16 women age 60 and older, brisk walking for 30-50 minutes three or four times per week improved blood flow through to the brain as much as 15% ... At study's end, the team measured blood flow in the women's carotid arteries again and found that cerebral blood flow increased an average of 15% and 11% in the women's left and right internal carotid arteries, respectively. The women's VO2 max increased roughly 13%, their blood pressure dropped an average of 4%, and their heart rates decreased approximately 5% ... A steady, healthy flow of blood to the brain achieves two things. First, the blood brings oxygen, glucose and other nutrients to the brain, which are vital for the brain's health. Second, the blood washes away brain metabolic wastes such as amyloid-beta protein released into the brain's blood vessels. Amyloid-beta protein has been implicated in the development of Alzheimer's disease"
  • Docosahexaenoic Acid reduces amyloid {beta} production via multiple, pleiotropic mechanism - J Biol Chem. 2011 Feb 15 - "Alzheimer's disease (AD) is characterized by accumulation of the amyloidogenic peptide Aβ generated by β- and γ-secretase processing of the amyloid precursor protein (APP). The intake of the polyunsaturated fatty acid (PUFA) docosahexaenoic acid (DHA) has been associated with decreased amyloid deposition and a reduced risk in AD in several epidemiological trials; however the exact underlying molecular mechanism remains to be elucidated ... DHA reduces amyloidogenic processing by decreasing β- and γ-secretase activity, whereas the expression and protein levels of BACE1 and Presenilin1 remain unchanged. In addition, DHA increases protein stability of α-secretase resulting in increased non-amyloidogenic processing. Beside the known effect of DHA to decrease cholesterol de novo synthesis, we found cholesterol distribution in plasma membrane to be altered. In presence of DHA, cholesterol shifts from raft to non-raft domains, which is accompanied by a shift in γ-secretase activity and Presenilin1 protein level. Taken together, DHA directs amyloidogenic processing of APP towards non-amyloidogenic processing, effectively reducing Aβ release. DHA has a typical pleiotropic effect; DHA-mediated Aβ reduction is not the consequence of a single major mechanism, but the result of combined multiple effects" - See Jarrow Max DHA at Amazon.com.
  • Good diets fight bad Alzheimer's genes: Diets high in fish oil have a beneficial effect in patients at risk, researcher says - Science Daily, 2/15/11 - "APOE comes in two forms, a "good" APOE gene and a "bad" APOE gene, called APOE4. He has developed animal models to investigate the effects of diet and environment on carriers of APOE4, the presence of which is a known risk factor for Alzheimer's. It appears in 50% of all Alzheimer's patients, and in 15% of the general population which due to APOE4 is the population which is at risk of getting the disease ... The good news? In preliminary results, the researchers are exhilarated to find that a diet high in Omega 3 oils and low in cholesterol appears to significantly reduce the negative effects of the APOE4 gene in mouse models" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
  • Protective properties of green tea uncovered - Science Daily, 1/5/11 - "Regularly drinking green tea could protect the brain against developing Alzheimer's and other forms of dementia" - See green tea extract at Amazon.com.
  • Higher HDL-C Levels May Curb Alzheimer's Disease Risk - Medscape, 12/16/10 - "There was a definite threshold effect, the researchers say, with a clear reduction in AD risk for people in the highest HDL-C level quartile (>56 mg/dL) ... these analyses were limited by the small number of cases of vascular dementia (n = 16) ... the current study linking higher HDL-C to a lower risk for incident dementia contrast with a prior study by the same researchers. This earlier study involved 1168 participants recruited from the same community in 1992 – 1994 and showed no association between HDL-C and AD ... Compared with the 1992 – 1994 cohort, the 1999 – 2001 cohort had a higher proportion of subjects receiving lipid-lowering treatment (23.4% vs 14.5%), higher mean HDL-C levels (48.3 vs 47.2 mg/dL), and fewer individuals who smoked (9.4% vs 10.6%) and had heart disease (18.8% vs 34.1%)"
  • High levels of 'good' cholesterol may be associated with lower risk of Alzheimer's disease - Science Daily, 12/13/10 - "The researchers defined higher levels of HDL cholesterol as 55 milligrams per deciliter or more ... higher levels of HDL cholesterol were associated with a decreased risk of both probable and possible Alzheimer's disease"
  • Blueberries and other purple fruits to ward off Alzheimer's, Multiple Sclerosis and Parkinson's - Science Daily, 12/7/10 - "Eating purple fruits such as blueberries and drinking green tea can help ward off diseases including Alzheimer's, Multiple Sclerosis and Parkinson's ... the majority of debilitating illnesses are in part caused by poorly-bound iron which causes the production of dangerous toxins that can react with the components of living systems ... These toxins, called hydroxyl radicals, cause degenerative diseases of many kinds in different parts of the body ... In order to protect the body from these dangerous varieties of poorly-bound iron, it is vital to take on nutrients, known as iron chelators, which can bind the iron tightly" - See blueberry extract at Amazon.com and green tea extract at Amazon.com.
  • Chronic high cholesterol diet produces brain damage - Science Daily, 11/24/10 - "chronic high fat cholesterol diet in rats exhibited pathologies similar to Alzheimer's disease ... A third hypothesis suggests that chronic long-lasting mild cerebrovascular damage, including inflammatory processes and oxidative stress, may cause Alzheimer's disease ... chronic hypercholesterolemia [in rats] caused memory impairment, cholinergic dysfunction, inflammation, enhanced cortical beta-amyloid and tau and induced microbleedings, all indications, which resemble an Alzheimer's disease-like pathology"
  • Homocysteine and holotranscobalamin and the risk of Alzheimer disease: A longitudinal study - Neurology. 2010 Oct 19;75(16):1408-14 - "homocysteine (tHcy) and holotranscobalamin (holoTC), the active fraction of vitamin B12 ... The odds ratios (ORs) (95% confidence interval [CI]) for AD were 1.16 (1.04-1.31) per increase of 1 μmol/L of tHcy at baseline and 0.980 (0.965-0.995) for each increase of 1 pmol/L baseline holoTC ... This study suggests that both tHcy and holoTC may be involved in the development of AD. The tHcy-AD link may be partly explained by serum holoTC. The role of holoTC in AD should be further investigated"
  • Vitamin B12 May Curb Risk for Alzheimer's Disease - Medscape, 10/18/10 - "holotranscobalamin (holoTC), the biologically active fraction of vitamin B12 ... for each 1-µmol/L increase in the baseline concentration of tHcy, the risk for AD increased by 16% (odds ratio [OR], 1.16; 95% confidence interval [CI], 1.04 – 1.31). On the other hand, for each 1-pmol/L increase in baseline holoTC, the risk for AD was reduced by 2% (OR, 0.980; 95% CI, 0.965 – 0.995)" - [Science Daily] - See vitamin B12 at Amazon.com.
  • Subclinical Zinc Deficiency in Alzheimer's Disease and Parkinson's Disease - Am J Alzheimers Dis Other Demen. 2010 Sep 14 - "Results showed a significantly lower blood zinc in patients with Alzheimer's and patients with Parkinson's than in controls. Urine zinc excretion, normalized to urine creatinine excretion, was not significantly different in either patient group compared to controls. These patients are probably zinc deficient because of nutritional inadequacy" - Note:  Zinc interferes with copper and too much zinc can cause a deficiency of copper.  See Jarrow Zinc Balance at Amazon.com.
  • B vitamins slow brain atrophy in people with memory problems - Science Daily, 9/12/10 - "on average the brains of those taking the folic acid, vitamin B6 and B12 treatment shrank at a rate of 0.76% a year, while those in the placebo group had a mean brain shrinkage rate of 1.08%. People with the highest levels of homocysteine benefited most, showing atrophy rates on treatment that were half of those on placebo"
  • Vitamin B is revolutionary new weapon against Alzheimer's Disease telegraph.co.uk, 9/9/10 - "Mild Cognitive Impairment (MCI) – a kind of memory loss and forgetfulness – and Alzheimer's ... On average, taking B vitamins slowed the rate of brain atrophy by 30 per cent, and in many cases reductions was as high as 53 per cent were seen"
  • Vitamin B may help prevent Alzheimer’s - Nutra USA, 9/9/10 - "The authors concluded that an accelerated rate of brain atrophy in elderly people with mild cognitive impairment could be slowed via dietary supplementation with homocysteine-lowering B vitamins"
  • Vitamin D status and measures of cognitive function in healthy older European adults - Eur J Clin Nutr. 2010 Aug 11 - "Serum 25(OH)D was significantly and inversely correlated with four assessments within the spatial working memory (SWM) test parameter (SWM between errors (r=-0.166; P=0.003); SWM between errors 8 boxes (r=-0.134; P=0.038); SWM strategy (r=-0.246; P<0.0001); and SWM total errors (r=-0.174; P<0.003)). When subjects were stratified on the basis of tertiles (T) of serum 25(OH)D (<47.6 (T(1)); 47.6-85.8 (T(2)); and >85.8 (T(3)) nmol/l), fewer errors in SWM test scores occurred in subjects in the third T when compared with the first T (P<0.05-0.084). Stratification by sex showed that these differences between tertiles strengthened (P<0.001-0.043) in the females, but the differences were not significant (P>0.6) in males.Conclusions:Vitamin D insufficiency, but not deficiency, is widespread in the older population of several European countries. Low vitamin D status was associated with a reduced capacity for SWM, particularly in women" - See vitamin D at Amazon.com.
  • Natural substance NT-020 aids aging brains in rats, study finds - Science Daily, 7/20/10 - "Aging has been linked to oxidative stress, and we have previously shown that natural compounds made from blueberries, green tea, and amino acids, such as carnosine, are high in antioxidants and have anti-inflammatory and anti-oxidative activity .... The combination of these nutrients, called NT-020, creates a synergistic effect that promotes the proliferation of stem cells in the aged animals ... NT-020 may have not only a positive effect on the stem cell niche ... NT-020 may have far-reaching effects on organ function beyond the replacement of injured cells, as demonstrated by cognitive improvement in the NT-020 group"
  • Low vitamin D levels associated with cognitive decline - Science Daily, 7/12/10 - "An estimated 40 percent to 100 percent of older adults in the United States and Europe are deficient in vitamin D ... Participants who were severely deficient in vitamin D (having blood levels of 25-hydroxyvitamin D of less than 25 nanomoles per liter) were 60 percent more likely to have substantial cognitive decline in general over the six-year period and 31 percent more likely to experience declines on the test measuring executive function than those with sufficient vitamin D levels" - See vitamin D at Amazon.com.
  • Sirtuin1 may boost memory and learning ability; Discovery could lead to new drugs to fight Alzheimer's, other neurological diseases - Science Daily, 7/11/10 - "Resveratrol, found in wine, has been touted as a life-span enhancer because it activates a group of enzymes known as sirtuins, which have gained fame in recent years for their ability to slow the aging process. Now MIT researchers report that Sirtuin1 -- a protein that in humans is encoded by the SIRT1 gene -- also promotes memory and brain flexibility ... We have now found that SIRT1 activity also promotes plasticity and memory" - See resveratrol products at Amazon.com.
  • High blood levels of vitamin E reduces risk of Alzheimer's, Swedish study finds - Science Daily, 7/7/10 - "High levels of several vitamin E components in the blood are associated with a decreased risk for Alzheimer's disease (AD) in advanced age, suggesting that vitamin E may help prevent cognitive deterioration in elderly people. This is the conclusion reached in a Swedish study ... Vitamin E is a family of eight natural components, but most studies related to Alzheimer's disease investigate only one of these components, +/--tocopherol ... We hypothesized that all the vitamin E family members could be important in protecting against AD ... subjects with higher blood levels of all the vitamin E family forms had a reduced risk of developing AD, compared to subjects with lower levels. After adjusting for various confounders, the risk was reduced by 45-54%, depending on the vitamin E component" - See Jarrow FamilE (contains all eight members of the vitamin E family, includes Tocomin) at Amazon.com
  • Compound found in red wine neutralizes toxicity of proteins related to Alzheimer's - Science Daily, 6/22/10 - "An organic compound found in red wine -- resveratrol -- has the ability to neutralize the toxic effects of proteins linked to Alzheimer's disease ... this molecule can target some of these packing arrangements that are toxic and rearrange them into packing arrangements that are not toxic. For those forms that are non-toxic, it doesn't change them" - See resveratrol products at Amazon.com.
  • Alcohol consumption may protect against risk of Alzheimer's disease, particularly in female nonsmokers, study finds 0 Science Daily, 5/24/10
  • Caffeine may slow Alzheimer's disease and other dementias, restore cognitive function, according to new evidence - Science Daily, 5/17/10 - "Key findings ... Multiple beneficial effects of caffeine to normalize brain function and prevent its degeneration ... Caffeine's neuroprotective profile and its ability to reduce amyloid-beta production ... Caffeine as a candidate disease-modifying agent for Alzheimer's disease ... Positive impact of caffeine on cognition and memory performance ... Identification of adenosine A2A receptors as the main target for neuroprotection afforded by caffeine consumption ... Confirmation of data through valuable meta-analyses presented ... Epidemiological studies corroborated by meta-analysis suggesting that caffeine may be protective against Parkinson's disease"
  • Low Vitamin D Level Tied to Cognitive Decline - WebMD, 4/16/10 - "Two new studies add to evidence that older people with low levels of vitamin D may be more likely to suffer from cognitive impairment. ... Results showed that the lower their score on the test, the lower their vitamin D levels" - See vitamin D at Amazon.com.
  • Exercise Plays a Preventive Role Against Alzheimer's Disease - J Alzheimers Dis. 2010 Feb 24 - "Regular physical activity increases the endurance of cells and tissues to oxidative stress, vascularization, energy metabolism, and neurotrophin synthesis, all important in neurogenesis, memory improvement, and brain plasticity. Although extensive studies are required to understand the mechanism, it is clear that physical exercise is beneficial in the prevention of AD and other age-associated neurodegenerative disorders"
  • Caffeine Intake is Associated with a Lower Risk of Cognitive Decline: A Cohort Study from Portugal - J Alzheimers Dis. 2010 Feb 24 - "Caffeine intake (> 62 mg/day [3rd third] vs. < 22 mg/day [1st third]) was associated with a lower risk of cognitive decline in women (RR=0.49, 95%CI 0.24-0.97), but not significantly in men (RR=0.65, 95%CI 0.27-1.54)" - Note:  I don't know how they determine that 0.65 isn't significant.
  • Caffeine as a Protective Factor in Dementia and Alzheimer's Disease - J Alzheimers Dis. 2010 Feb 24 - "In the CAIDE study, coffee drinking of 3-5 cups per day at midlife was associated with a decreased risk of dementia/AD by about 65% at late-life. In conclusion, coffee drinking may be associated with a decreased risk of dementia/AD. This may be mediated by caffeine and/or other mechanisms like antioxidant capacity and increased insulin sensitivity. This finding might open possibilities for prevention or postponing the onset of dementia/AD"
  • DHA May Prevent Age-Related Dementia - J Nutr. 2010 Feb 24 - "DHA is pleiotropic, acting at multiple steps to reduce the production of the beta-amyloid peptide, widely believed to initiate AD. DHA moderates some of the kinases that hyperphosphorylate the tau-protein, a component of the neurofibrillary tangle. DHA may help suppress insulin/neurotrophic factor signaling deficits, neuroinflammation, and oxidative damage that contribute to synaptic loss and neuronal dysfunction in dementia. Finally, DHA increases brain levels of neuroprotective brain-derived neurotrophic factor and reduces the (n-6) fatty acid arachidonate and its prostaglandin metabolites that have been implicated in promoting AD. Clinical trials suggest that DHA or fish oil alone can slow early stages of progression, but these effects may be apolipoprotein E genotype specific, and larger trials with very early stages are required to prove efficacy. We advocate early intervention in a prodromal period with nutrigenomically defined subjects with an appropriately designed nutritional supplement, including DHA and antioxidants" - See Jarrow Max DHA at Amazon.com.
  • Docosahexaenoic Acid Deficiency and Prefrontal Cortex Neuropathology in Recurrent Affective Disorders - J Nutr. 2010 Feb 10 - "Increasing evidence suggests that docosahexaenoic acid [DHA, 22:6(n-3)], the principal (n-3) fatty acid in brain gray matter, has neurotrophic and neuroprotective properties. Preliminary clinical evidence also suggests that the perinatal accrual, and the subsequent dietary maintenance of, cortical DHA is positively associated with cortical gray matter volumes. The pathophysiology of recurrent affective disorders, including unipolar and bipolar depression, is associated with (n-3) fatty acid deficiency, DHA deficits, impaired astrocyte mediated vascular coupling, neuronal shrinkage, and reductions in gray matter volume in the prefrontal cortex (PFC). Preclinical studies have also observed neuronal shrinkage and indices of astrocyte pathology in the DHA-deficient rat brain. Together, this body of evidence supports the proposition that DHA deficiency increases vulnerability to neuronal atrophy in the PFC of patients with affective disorders" - See Jarrow Max DHA at Amazon.com.
  • Omega-3 may reduce risk of Alzheimer’s: Rat study - Nutra USA, 2/1/10 - "This study, for the first time, reported […] a clear correlation between the decrease in acetylcholine release and memory deficit, [and] E-EPA improves memory by attenuating the reduction of acetylcholine release and nerve growth factor expression ... In this study, our findings add further evidence that E-EPA may improve memory by the modulation of acetylcholineand neurotrophin functions" - See Mega Twin EPA at Amazon.com.
  • Reductions of acetylcholine release and nerve growth factor expression are correlated with memory impairment induced by interleukin-1beta administrations: effects of omega-3 fatty acid EPA treatment - J Neurochem. 2009 Dec 3 - "E-EPA treatment significantly improved the memory, which was correlated with normalizing ACh release, and expressions of NGF and IL-1beta" - See Mega Twin EPA at Amazon.com.
  • Flavonoid intake and disability-adjusted life years due to Alzheimer's and related dementias: a population-based study involving twenty-three developed countries - Public Health Nutr. 2010 Jan 11:1-7 - "Flavonols and combined flavonoids (all five combined) intakes were the only two parameters with significant (P < 0.05) negative dementia correlations. Multiple linear regression models confirmed this relationship, and excluded confounding from some other dietary and non-dietary factors. Similar analyses with non-dementia, neurological/psychiatric diseases did not yield significant correlations. CONCLUSIONS: At a global level, and in the context of different genetic backgrounds, our results suggest that higher consumption of dietary flavonoids, especially flavonols, is associated with lower population rates of dementia in these countries"
  • Green tea chemical combined with another may hold promise for treatment of brain disorders - Science Daily, 12/3/09 - "Scientists at Boston Biomedical Research Institute (BBRI) and the University of Pennsylvania have found that combining two chemicals, one of which is the green tea component EGCG, can prevent and destroy a variety of protein structures known as amyloids. Amyloids are the primary culprits in fatal brain disorders such as Alzheimer's, Huntington's, and Parkinson's diseases" - See green tea extract at Amazon.com.
  • 25-Hydroxyvitamin D, dementia, and cerebrovascular pathology in elders receiving home services - Neurology. 2009 Nov 25 - "Vitamin D insufficiency and deficiency was associated with all-cause dementia, Alzheimer disease, stroke (with and without dementia symptoms), and MRI indicators of cerebrovascular disease. These findings suggest a potential vasculoprotective role of vitamin D" - See vitamin D at Amazon.com.
  • Polyphenols and polyunsaturated fatty acids boost the birth of new neurons, study finds - Science Daily, 11/24/09 - "a diet rich in polyphenols and polyunsaturated fatty acids, patented as an LMN diet, helps boost the production of the brain's stem cells -neurogenesis- and strengthens their differentiation in different types of neuron cells ... mice fed an LMN diet, when compared to those fed a control diet, have more cell proliferation in the two areas of the brain where neurogenesis is produced, the olfactory bulb and the hippocampus, both of which are greatly damaged in patients with Alzheimer's disease ... Polyphenols can be found in tea, beer, grapes, wine, olive oil, cocoa, nuts and other fruits and vegetables. Polyunsaturated fatty acids can be found in blue fish and vegetables such as corn, soya beans, sunflowers and pumpkins"
  • NSAIDs Prevent Early Sign Of Alzheimer Disease In Mice Science Daily, 11/12/09 - "If taking nonsteroidal antiinflammatory drugs (NSAIDs) such as ibuprofen or naproxen is to protect you from developing Alzheimer disease then you will have to start taking them at a very early age according to research in a mouse model of the disease"
  • Olive oil component could avert Alzheimer’s - Nutra USA, 10/20/09 - "ADDLs bind within the neural synapses of the brains of Alzheimer's patients and are believed to directly disrupt nerve cell function, eventually leading to memory loss, cell death and global disruption of brain function ... incubation with oleocanthal changed the structure of ADDLs by increasing the protein's size" - [Abstract] - See olive leaf extract at Amazon.com.
  • Alzheimer's-associated Abeta oligomers show altered structure, immunoreactivity and synaptotoxicity with low doses of oleocanthal - Toxicol Appl Pharmacol. 2009 Oct 15;240(2):189-97 - "results indicate oleocanthal is capable of altering the oligomerization state of ADDLs while protecting neurons from the synaptopathological effects of ADDLs and suggest OC as a lead compound for development in AD therapeutics" - See olive leaf extract at Amazon.com.
  • Nuts, Vegetables, Fish Cut Alzheimer's Risk - WebMD, 10/14/09 - "we discovered an Alzheimer's-disease-protective dietary pattern that was characterized by a high consumption of nuts, fish, salad dressing, poultry, tomatoes, cruciferous, dark, and green leafy vegetables and fruits, and low in high-fat dairy, red meat, organ meat, and butter"
  • Protective Role For Copper In Alzheimer’s Disease - Science Daily, 10/8/09 - "Two articles in a forthcoming issue of the Journal of Alzheimer’s Disease -- by Dr Chris Exley, Reader in Bioinorganic Chemistry in the Research Institute for the Environment, Physical Sciences and Applied Mathematics at Keele University, UK, and Dr Zhao-Feng Jiang, of Beijing Union University, Beijing, China -- have confirmed a potentially protective role for copper in Alzheimer’s disease" - See Jarrow Zinc Balance at Amazon.com. Note: High quantities of zinc can lower copper.
  • Natural Compound In Extra-virgin Olive Oil -- Oleocanthal -- May Help Prevent, Treat Alzheimer's - Science Daily, 9/29/09 - "Measuring ADDL binding with and without oleocanthal, they discovered that small amounts of oleocanthal effectively reduced binding of ADDLs to hippocampal synapses. Additional studies revealed that oleocanthal can protect synapses from structural damage caused by ADDLs ... An unexpected finding was that oleocanthal makes ADDLs into stronger targets for antibodies. This action establishes an opportunity for creating more effective immunotherapy treatments, which use antibodies to bind to and attack ADDLs" - See olive leaf extract at Amazon.com.
  • Sleep Loss Linked To Increase In Alzheimer's Plaques - Science Daily, 9/24/09 - "Chronic sleep deprivation in a mouse model of Alzheimer's disease makes Alzheimer's brain plaques appear earlier and more often"
  • How To Boost Value Of Alzheimer's-fighting Compounds - Science Daily, 9/7/09 - "Connie Weaver, Purdue's head of foods and nutrition; and Elsa Janle, a Purdue associate professor of foods and nutrition, found that the amount of polyphenols from grapeseed extract that can reach a rat's brain is as much as 200 percent higher on the 10th consecutive day of feeding as compared to the first. Many previous experiments, in which absorption was measured after single or sporadic doses, often found very little, if any, of the bioactive polyphenols reaching brain tissues. However, more chronic exposure appears to improve absorption ... This shows that reasonable and chronic consumption of these products may be the way to go, rather than single, high doses" - See grape seed extract at Amazon.com.
  • More Obesity Blues: Obese People Are At Greater Risk For Developing Alzheimer's, Study Finds - Science Daily, 8/25/09 - "They found that obese people had 8 percent less brain tissue than people with normal weight, while overweight people had 4 percent less tissue. According to Thompson, who is also a member of UCLA's Laboratory of Neuro Imaging, this is the first time anyone has established a link between being overweight and having what he describes as "severe brain degeneration.""
  • Green Tea (-)-Epigallocatechin-3-Gallate Inhibits {beta}-Amyloid-Induced Cognitive Dysfunction through Modification of Secretase Activity via Inhibition of ERK and NF-{kappa}B Pathways in Mice - J Nutr. 2009 Aug 5 - "Compared with untreated mutant PS2 AD mice, treatment with EGCG enhanced memory function and brain alpha-secretase activity but reduced brain beta- and gamma-secretase activities as well as Abeta levels. Moreover, EGCG inhibited the fibrillization of Abeta in vitro with a half maximal inhibitory concentration of 7.5 mg/L. These studies suggest that EGCG may be a beneficial agent in the prevention of development or progression of AD" - See green tea extract at Amazon.com.
  • 'Brain Exercises' May Delay Memory Decline In Dementia - Science Daily, 8/4/09 - "People who engage in activities that exercise the brain, such as reading, writing, and playing card games, may delay the rapid memory decline that occurs if they later develop dementia"
  • Vit D-curcumin combo offers brain health potential - Nutra USA, 7/27/09 - "The curcuminoids were found to enhance binding of beta-amyloid to macrophages, and that vitamin D could strongly stimulate the uptake and absorption of beta-amyloid in macrophages in most of the patients ... Since vitamin D and curcumin work differently with the immune system, we may find that a combination of the two or each used alone may be more effective — depending on the individual patient" - [Abstract] - See vitamin D at Amazon.comand curcumin products at Amazon.com.
  • 1α,25-dihydroxyvitamin D_{3} Interacts with Curcuminoids to Stimulate Amyloid-β Clearance by Macrophages of Alzheimer's Disease Patient - J Alzheimers Dis. 2009 May 11 - "1,25D3 strongly stimulated Abeta phagocytosis and clearance while protecting against apoptosis. Certain synthetic curcuminoids in combination with 1,25D3 had additive effects on phagocytosis in Type I but not Type II macrophages. In addition, we investigated the mechanisms of 1,25D3 and curcuminoids in macrophages. The 1,25D3 genomic antagonist analog MK inhibited 1,25D3 but not curcuminoid effects, suggesting that 1,25D3 acts through the genomic pathway. In silico, 1,25D3 showed preferential binding to the genomic pocket of the vitamin D receptor, whereas bisdemethoxycurcumin showed preference for the non-genomic pocket. 1,25D3 is a promising hormone for AD immunoprophylaxis because in Type I macrophages combined treatment with 1,25D3 and curcuminoids has additive effects, and in Type II macrophages 1,25D3 treatment is effective alone. Human macrophages are a new paradigm for testing immune therapies for AD" - See vitamin D at Amazon.comand curcumin products at Amazon.com.
  • Antioxidant effect of lutein towards phospholipid hydroperoxidation in human erythrocytes - Br J Nutr. 2009 Jul 22:1-5 - "These results suggest that lutein has the potential to act as an important antioxidant molecule in erythrocytes, and it thereby may contribute to the prevention of dementia" - See lutein at Amazon.com.
  • Chemicals Found In Fruit And Vegetables Offer Dementia Hope - Science Daily, 7/19/09 - "a new concept is emerging that suggests flavonoids do not act simply as antioxidants but exert their biological effects through other mechanisms. A small number of recent studies carried out in models of Alzheimer’s disease have found that oral administration of green tea flavonoids or grape flavonoids reduces brain pathology and, in some cases, improves cognition. Dr Williams and colleagues have focused their own cellular studies on a flavonoid called epicatechin, which is abundant in a number of foodstuffs, including cocoa ... epicatechin protects brain cells from damage but through a mechanism unrelated to its antioxidant activity and shown in laboratory tests that it can also reduce some aspects of Alzheimer’s disease pathology" - See Jarrow Formulas, OPCs + 95 at Amazon.com at iHerb.
  • Vitamin D, Curcumin May Help Clear Amyloid Plaques Found In Alzheimer's Disease - Science Daily, 7/15/09 - "The team discovered that curcuminoids enhanced the surface binding of amyloid beta to macrophages and that vitamin D strongly stimulated the uptake and absorption of amyloid beta in macrophages in a majority of patients ... Since vitamin D and curcumin work differently with the immune system, we may find that a combination of the two or each used alone may be more effective — depending on the individual patient" - See curcumin products at Amazon.com and vitamin D at Amazon.com.
  • Oily fish may reduce dementia risk: Transcontinental study - Nutra USA, 7/8/09 - "Almost 15,000 people aged 65 or over were surveyed. After adjusting for various confounders and pooling the data from all the sites, the researchers report that they observed a dose-dependent inverse association between dementia and fish consumption" - [Abstract] - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
  • Dietary fish and meat intake and dementia in Latin America, China, and India: a 10/66 Dementia Research Group population-based study - Am J Clin Nutr. 2009 Jun 24 - "We found a dose-dependent inverse association between fish consumption and dementia (PR: 0.81; 95% CI: 0.72, 0.91) that was consistent across all sites except India and a less-consistent, dose-dependent, direct association between meat consumption and prevalence of dementia (PR: 1.19; 95% CI: 1.07, 1.31)" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
  • Caffeine Reverses Memory Impairment In Mice With Alzheimer's Symptoms - Science Daily, 7/6/09 - "Coffee drinkers may have another reason to pour that extra cup. When aged mice bred to develop symptoms of Alzheimer's disease were given caffeine – the equivalent of five cups of coffee a day – their memory impairment was reversed"
  • Silibinin prevents amyloid beta peptide-induced memory impairment and oxidative stress in mice - Br J Pharmacol. 2009 Jun 22 - "Silibinin (silybin), a flavonoid derived from the herb milk thistle (Silybum marianum), has been shown to have antioxidative properties; however, it remains unclear whether silibinin improves Abeta-induced neurotoxicity ... Silibinin prevented the memory impairment induced by Abeta(25-35) in the Y-maze and novel object recognition tests. Repeated treatment with silibinin attenuated the Abeta(25-35)-induced accumulation of malondialdehyde and depletion of glutathione in the hippocampus ... Silibinin prevents memory impairment and oxidative damage induced by Abeta(25-35) and may be a potential therapeutic agent for Alzheimer's disease" - See silymarin at Amazon.com.
  • Alcohol consumption as a risk factor for dementia and cognitive decline: meta-analysis of prospective studies - Am J Geriatr Psychiatry. 2009 Jul;17(7):542-55 - "Alzheimer disease (AD) ... vascular dementia (VaD) ... The pooled relative risks (RRs) of AD, VaD, and Any dementia for light to moderate drinkers compared with nondrinkers were 0.72 (95% CI = 0.61-0.86), 0.75 (95% CI = 0.57-0.98), and 0.74 (95% CI = 0.61-0.91), respectively. When the more generally classified "drinkers," were compared with "nondrinkers," they had a reduced risk of AD (RR = 0.66, 95% CI = 0.47-0.94) and Any dementia (RR = 0.53, 95% CI = 0.53-0.82) but not cognitive decline. There were not enough data to examine VaD risk among "drinkers." Those classified as heavy drinkers did not have an increased risk of Any dementia compared with nondrinkers, but this may reflect sampling bias. Our results suggest that alcohol drinkers in late life have reduced risk of dementia. It is unclear whether this reflects selection effects in cohort studies commencing in late life, a protective effect of alcohol consumption throughout adulthood, or a specific benefit of alcohol in late life"
  • Statins Can Protect Against Alzheimer’s Disease, According To New Study - Science Daily, 6/22/09 - "They clearly demonstrated that treatment with a statin called Lovastatin could prevent the death of nerve cells under these conditions. The statins not only prevented cells from dying but also prevented the loss of memory capacity that normally occurs after such cell death. In a previous study Dolga had showed that these statins stimulate the protective capacity of tumor necrosis factor, which is a key player in the brain’s immune response" - [Abstract] - Note:  Lovastatin is in red yeast rice.  See red yeast rice at Amazon.com.
  • Pretreatment with Lovastatin Prevents N-Methyl-D-Aspartate-Induced Neurodegeneration in the Magnocellular Nucleus Basalis and Behavioral Dysfunction - J Alzheimers Dis. 2009 Mar 6 - "From these studies we conclude that treatment with lovastatin may provide protection against neuronal injury in excitotoxic conditions associated with neurodegenerative diseases including Alzheimer's disease" - Note:  Lovastatin (that's the generic name and therefore shouldn't be capitalized) is in red yeast rice.  See red yeast rice at Amazon.com.
  • Is Vitamin D Deficiency Linked To Alzheimer's Disease And Vascular Dementia? - Science Daily, 5/26/09 - "Several studies have correlated tooth loss with development of cognitive impairment and Alzheimer's disease or vascular dementia. There are two primary ways that people lose teeth: dental caries and periodontal disease. Both conditions are linked to low vitamin D levels, with induction of human cathelicidin by 1,25-dihydroxyvitamin D being the mechanism ... There is also laboratory evidence for the role of vitamin D in neuroprotection and reducing inflammation, and ample biological evidence to suggest an important role for vitamin D in brain development and function ... those over the age of 60 years should consider having their serum 25(OH)D tested, looking for a level of at least 30 ng/mL but preferably over 40 ng/mL, and supplementing with 1000-2000 IU/day of vitamin D3 or increased time in the sun spring, summer, and fall if below those values" - See vitamin D at Amazon.com.
  • High-Dose Vitamin E Slows Functional Decline in Alzheimer's Disease - Medscape, 5/4/09 - "The clinical-effectiveness study enrolled 540 patients with probable Alzheimer's disease (324 women) who had a mean age of nearly 74 years. All were receiving 1 of the following cholinesterase inhibitors: donepezil, rivastigmine, or galantamine (800 to 1000 U twice daily). In addition, 208 patients received vitamin E (800 to 2000 IU/day) ... Vitamin E treatment showed small to medium effect sizes in slowing functional decline, the abstract reports. For vitamin E, the ADL Cohen's d significantly increased, from 0.20 in year 1 (P = .02) to 0.42 by year 5 (P < .001)"
  • Cholinesterase Inhibition Combined With Antioxidants May Help Alzheimer's Disease Outcomes - Doctor's Guide, 3/17/09 - "Addition of a defined antioxidants formulation (Formula F) to donepezil treatment of patients with mild Alzheimer's disease (AD) substantially reduces oxidative stress and provides significant benefits over treatment with donepezil alone"
  • Folate Deficiency May Triple Dementia Risk in the Elderly - Medscape, 3/3/09 - "individuals who were folate deficient at study outset were 3.5 times more likely to develop dementia" - See folic acid products at Amazon.com.
  • Role of Huperzine A in the Treatment of Alzheimer's Disease - Ann Pharmacother. 2009 Feb 24 - "AD is a progressive neurodegenerative brain disorder for which there is no cure; available therapies only decrease cognitive decline. Huperzine A, an alkaloid derived from Chinese club moss (H. serrata), acts as a selective inhibitor of acetylcholinesterase and may also display neuroprotective properties. Preliminary data suggest that huperzine A may improve cognition; studies ranging from 8 to 12 weeks have found improvements in the Mini-Mental State Examination score of 1-5 points ... Although use of huperzine A has shown promising results in patients with AD, data supporting its use are limited by weak study design" - See huperzine at Amazon.com.
  • Mediterranean Diet May Preserve Memory - WebMD, 2/9/09 - "The Mediterranean diet consists of larger doses of fish, vegetables, legumes, fruits, cereals, and unsaturated fatty acids; low amounts of dairy products, meat, and saturated fats; and a moderate amount of alcohol ... average 4.5 year follow-up period. Those in the top one-third of Mediterranean diet scores had a 28% lower risk (compared to those in the bottom third) of developing a cognitive impairment"
  • Coffee lovers face lower dementia risk - MSNBC, 2/3/09 - "among 1,400 Finnish adults followed for 20 years, those who drank three to five cups of coffee per day in middle-age were two-thirds less likely than non-drinkers to develop dementia, including Alzheimer's disease"
  • Apple Juice Can Delay Onset Of Alzheimer's Disease, Study Suggests - Science Daily, 1/22/09 - "drinking apple juice helped mice perform better than normal in maze trials, and prevented the decline in performance that was otherwise observed as these mice aged ... mice receiving the human equivalent of 2 glasses of apple juice per day for 1 month produced less of a small protein fragment, called "beta-amyloid" that is responsible for forming the "senile plaques" that are commonly found in brains of individuals suffering from Alzheimer's disease"
  • Low Levels Of Vitamin D Link To Cognitive Problems In Older People - Science Daily, 1/22/09 - "Researchers from the Peninsula Medical School, the University of Cambridge and the University of Michigan, have for the first time identified a relationship between Vitamin D, the "sunshine vitamin", and cognitive impairment in a large-scale study of older people ... as levels of Vitamin D went down, levels of cognitive impairment went up. Compared to those with optimum levels of Vitamin D, those with the lowest levels were more than twice as likely to be cognitively impaired" - See vitamin D at Amazon.com.
  • Midlife Coffee And Tea Drinking May Protect Against Late-life Dementia - Science Daily, 1/14/09 - "coffee drinkers at midlife had lower risk for dementia and AD later in life compared to those drinking no or only little coffee. The lowest risk (65% decreased) was found among moderate coffee drinkers (drinking 3-5 cups of coffee/day). Adjustments for various confounders did not change the results. Tea drinking was relatively uncommon and was not associated with dementia/AD"
  • Neuroprotective Effects of (-)-Epigallocatechin-3-gallate on Aging Mice Induced by D-Galactose - Biol Pharm Bull. 2009 Jan;32(1):55-60 - "aim of the present study was to investigate the protective effects of (-)-epigallocatechin-3-gallate (EGCG), the main polyphenolic constituent of green tea ... Oral administration of EGCG (2 mg/kg or 6 mg/kg) for 4 weeks significantly improved the cognitive deficits in mice and elevated T-SOD and GSH-Px activities, decreased MDA contents in the hippocampus, and reduced the cell apoptosis index and expression of cleaved caspase-3 in the mouse hippocampus. The results suggest that EGCG has potent neuroprotective effects on aging mice induced by D-gal through antioxidative and antiapoptotic mechanisms, indicating that EGCG is worthy of further study in aging" - See green tea extract at Amazon.com.
  • Blood Sugar Linked To Normal Cognitive Aging - Science Daily, 12/30/08 - "Beyond the obvious conclusion that preventing late-life disease would benefit the aging hippocampus, our findings suggest that maintaining blood sugar levels, even in the absence of diabetes, could help maintain aspects of cognitive health. More specifically, our findings predict that any intervention that causes a decrease in blood glucose should increase dentate gyrus function and would therefore be cognitively beneficial" - [WebMD]
  • Moderate Drinking Can Reduce Risks Of Alzheimer's Dementia And Cognitive Decline - Science Daily, 12/29/08 - "Alcohol is a two-edged sword ... Too much is bad. But a little might actually be helpful"
  • Berry Compound Reduces Aging Effect - Science Daily, 12/28/08 - "in aging rats, pterostilbene was effective in reversing cognitive decline and that improved working memory was linked to pterostilbene levels in the hippocampus region of the brain"
  • Berry extracts may ease age-related mental decline: Study - Nutra USA, 12/12/08 - "The results indicated that in aging rats, pterostilbene was effective in reversing the decline in cognitive function that occurs with naturally with age, and that precedes diseases such as Alzheimer's" - [Abstract]
  • Efficacy of a Vitamin/Nutriceutical Formulation for Early-stage Alzheimer's Disease: A 1-Year, Open-Label Pilot Study With an 16-Month Caregiver Extension - Am J Alzheimers Dis Other Demen. 2008 Dec 1 - "We examined the efficacy of a vitamin/nutriceutical formulation (folate, vitamin B6, alpha-tocopherol, S-adenosyl methionine, N-acetyl cysteine, and acetyl-L-carnitine) in a 12-month, open-label trial with 14 community-dwelling individuals with early-stage Alzheimer's disease. Participants improved in the Dementia Rating Scale and Clock-drawing tests (Clox 1 and 2). Family caregivers reported improvement in multiple domains of the Neuropsychiatric Inventory (NPI) and maintenance of performance in the Alzheimer's Disease Cooperative Study-Activities of Daily Living (ADL). Sustained performance was reported by caregivers for those participants who continued in an 16-month extension. Performance on the NPI was equivalent to published findings at 3 to 6 months for donepezil and exceeded that of galantamine and their historical placebos. Participants demonstrated superior performance for more than 12 months in NPI and ADL versus those receiving naproxen and rofecoxib or their placebo group. This formulation holds promise for treatment of early-stage Alzheimer's disease prior to and/or as a supplement for pharmacological approaches"
  • Exercise Increases Brain Growth Factor And Receptors, Prevents Stem Cell Drop In Middle Age - Science Daily, 11/27/08 - "exercise significantly slows down the loss of new nerve cells in the middle-aged mice. They found that production of neural stem cells improved by approximately 200% compared to the middle-aged mice that did not exercise. In addition, the survival of new nerve cells increased by 170% and growth by 190% compared to the sedentary middle-aged mice. Exercise also significantly enhanced stem cell production and maturation in the young mice. In fact, exercise produced a stronger effect in younger mice compared to the older mice"
  • How Red Wine Compounds Fight Alzheimer's Disease - Science Daily, 11/23/08 - "Teplow's lab has been studying how amyloid beta (Aß) is involved in causing Alzheimer's. In this work, researchers monitored how Aß40 and Aß42 proteins folded up and stuck to each other to produce aggregates that killed nerve cells in mice. They then treated the proteins with a polyphenol compound extracted from grape seeds. They discovered that polyphenols carried a one-two punch: They blocked the formation of the toxic aggregates of Aß and also decreased toxicity when they were combined with Aß before it was added to brain cells" - See grape seed extract at Amazon.com.
  • Docosahexaenoic Acid and the Aging Brain - J Nutr. 2008 Dec;138(12):2510-2514 - "Deficits in DHA or its peroxidation appear to contribute to inflammatory signaling, apoptosis, and neuronal dysfunction in Alzheimer disease (AD), a common and progressive age-related neurological disorder unique to structures and processes of the human brain" - See Jarrow Max DHA at Amazon.com.
  • Ginkgo biloba has no benefits against dementia: Study - Nutra USA, 11/19/08 - "The GEM Study involved 3,069 community volunteers with an average age of 79.1 ... Commenting on the study, Dr Fabricant said the study had two major limitations: “One, it looks exclusively at people almost 80 years old who are far more likely to have Alzheimer’s, while ignoring those in middle ages, where the risk for developing the disease rises quickly and prevention could best be analyzed,” ... Two, it excludes completely any consideration of the strong and established role that family history plays with Alzheimer’s. You can’t do a study on the weather without looking at wind and rain.”"
  • Most ginkgo products fail quality testing - Nutra USA, 11/18/08 - "Some companies put less of it in their products than they claim or use ingredient that has been adulterated with inexpensive material that can fool non-specific tests ... companies continued to make products with little to no ginkgo in them, leading Consumerlab to suggest “ginkgo is among the most adulterated herbs.”" - That's why I stay with the top brand names.  They have more to loose with bad  press.  I also think that's why some studies show benefits with certain supplement while other studies don't.  I've been taking Nature's Way, Ginkgold.  I get the paid version of Consumerlab and I thought it was strange that they didn't test that brand. - Ben
  • Ginkgo Biloba Does Not Reduce Dementia Risk, Study Shows - Science Daily, 11/18/08 - "The researchers found no statistical difference in dementia or Alzheimer's disease rates between the groups. Among those taking G. biloba, 277 developed dementia. Among those in the placebo group, 246 developed dementia. Mortality rates also were similar" - I read this after the above article and comments but like I said.
  • Form of Vitamin B3 May Help Alzheimer's - WebMD, 11/4/08 - "Researchers from the University of California, Irvine dissolved nicotinamide in drinking water and fed it to mice with Alzheimer's. The researchers found that nicotinamide prevented mental deficits in mice with Alzheimer's. It also seemed to improve short-term memory of mice without Alzheimer's" - [Science Daily} - See nicotinamide adenine dinucleotide at Amazon.com.
  • High-fat Diet Could Promote Development Of Alzheimer's Disease - Science Daily, 10/28/08 - "the main neurological markers for Alzheimer's disease are exacerbated in the brains of mice fed a diet rich in animal fat and poor in omega-3s"
  • Effects of grape seed-derived polyphenols on amyloid beta -protein self-assembly and cytotoxicity - J Biol Chem. 2008 Sep 24 - "Alzheimer's disease (AD) ... studies showed that a commercially-available grape seed polyphenolic extract, MegaNatural-AZ (MN), significantly attenuated AD-type cognitive deterioration and reduced cerebral amyloid deposition" - See grape seed extract at Amazon.com.
  • Low plasma eicosapentaenoic acid and depressive symptomatology are independent predictors of dementia risk - Am J Clin Nutr. 2008 Sep;88(3):714-21 - "A high plasma EPA concentration may decrease the risk of dementia, whereas high ratios of n-6 to n-3 fatty acids and of AA to DHA may increase the risk of dementia, especially in depressed older persons. The role of EPA in dementia warrants further research" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
  • Walking Boosts Brainpower - WebMD, 9/2/08 - "Those in the exercise group scored higher on cognitive tests and had better delayed recall. For example, they could more accurately remember a list of words after a certain amount of time had passed than those in the other group ... Unlike medication, which was found to have no significant effect on mild cognitive impairment at 36 months, physical activity has the advantage of health benefits that are not confined to cognitive function alone, as suggested by findings on depression, quality of life, falls, cardiovascular function, and disability"
  • Eating Fish May Reduce the Risk for Subclinical Brain Abnormalities - Medscape, 8/7/08 - "Dietary intake of tuna and other fish appear to lower the prevalence of subclinical infarcts and white-matter abnormalities ... We also found that broiled and baked fish appeared to be beneficial, while fried fish was not ... The findings add to prior evidence suggesting fish with higher eicosapentaenoic and docosahexaenoic acid content appear to have clinically important health benefits" - See Mega Twin EPA at Amazon.com.
  • Exercise May Prevent Brain Shrinkage In Early Alzheimer's Disease - Science Daily, 7/14/08 - "People with early Alzheimer's disease who were less physically fit had four times more brain shrinkage when compared to normal older adults than those who were more physically fit"
  • Nutrient cocktail may boost memory and learning: study - Nutra USA, 7/10/08 - "It may be possible to use this [combination] to partially restore brain function in people with diseases that decrease the number of brain neurons, including, for example, Alzheimer's disease, Parkinson's, strokes and brain injuries. Of course, such speculations have to be tested in double-blind, placebo-controlled clinical trials ... supplemented the diets of gerbils with uridine (in its monophosphate form, 0.5 per cent) and choline (0.1 per cent), and docosahexaenoic acid (DHA, 300 mg/kg/day) for four weeks ... At the end of the study, significant increases in phospholipid levels in the brain were observed when the compounds were given together, while administration of only DHA or UMP or UMP plus choline produced smaller increases" - [Abstract] - See citicholine at Amazon.com and Jarrow Max DHA at Amazon.com.
  • Dietary uridine enhances the improvement in learning and memory produced by administering DHA to gerbils - FASEB J. 2008 Jul 7 - "These findings demonstrate that a treatment that increases synaptic membrane content can enhance cognitive functions in normal animals" - See citicholine at Amazon.com and Jarrow Max DHA at Amazon.com.
  • Panax Ginseng Enhances Cognitive Performance in Alzheimer Disease - Alzheimer Dis Assoc Disord. 2008 Jun 17 - "ginseng group was treated with Panax ginseng powder (4.5 g/d) for 12 weeks ... After ginseng treatment, the cognitive subscale of ADAS and the MMSE score began to show improvements and continued up to 12 weeks (P=0.029 and P=0.009 vs. baseline, respectively). After discontinuing ginseng, the improved ADAS and MMSE scores declined to the levels of the control group. These results suggest that Panax ginseng is clinically effective in the cognitive performance of AD patients" - See ginseng at Amazon.com.
  • Grape Seed Extract May Reduce Cognitive Decline Associated With Alzheimer's Disease - Science Daily, 6/17/08 - "Chemical analysis showed that the major polyphenol components in the study's grape seed extract product are catechin and epicatechin, which are also abundant in tea and cocoa. These components differ from resveratrol, a polyphenol that has been reported to reduce amyloid beta secretion in cells and generally increase lifespan by mimicking calorie restriction. Resveratrol appears to be effective only at extremely high doses, which may limit its use in people. In contrast, the catechins in the extract product studied appear to be effective at much lower doses" - My favorite is the Jarrow OPC + 95 at Amazon.com.
  • Exercise May Cut Risk of Dementia - WebMD, 6/3/08 - "In a study of more than 1,400 adults, those who were physically active in their free time during middle age were 52% less likely to develop dementia 21 years later than their sedentary counterparts. Their chance of developing Alzheimer's disease was slashed even more, by 62%"
  • DHA and Dementia: Preserving Cognition in the Aging Patient (Slides With Audio) - Medscape, 5/22/08 - Good slide show on DHA omega-3 for prevention of dementia and Alzheimer's.  It's 58 minutes though an a bit difficult to get quotes from it.
  • Plant Flavonoid In Celery And Green Peppers Found To Reduce Inflammatory Response In The Brain - Science Daily, 5/20/08 - "The new study looked at luteolin (LOO-tee-OH-lin), a plant flavonoid known to impede the inflammatory response in several types of cells outside the central nervous system ... Those cells that were also exposed to luteolin showed a significantly diminished inflammatory response. Jang showed that luteolin was shutting down production of a key cytokine in the inflammatory pathway, interleukin-6 (IL-6). The effects of luteolin exposure were dramatic, resulting in as much as a 90 percent drop in IL-6 production in the LPS-treated cells ... Inflammatory cytokines such as interleukin-6 are very well known to inhibit certain types of learning and memory that are under the control of the hippocampus, and the hippocampus is also very vulnerable to the insults of aging ... If you had the potential to decrease the production of inflammatory cytokines in the brain you could potentially limit the cognitive deficits that result" - See luteolin at Amazon.com.
  • Plants' Flavonoids Have Beneficial Effect On Alzheimer's Disease, Study In Mice Suggests - Science Daily, 5/7/08 - "Researchers administered molecules called flavonoids, which are found in certain fruits and vegetables, to a mouse model genetically programmed to develop Alzheimer's disease. Using two of these molecules, luteolin and diosmin, they were able to reduce the levels of a protein called amyloid-beta, which forms the sticky deposits that build up in the brains of patients with Alzheimer's" - See bioflavonoids at Amazon.com.
  • Ibuprofen May Cut Alzheimer's Risk - WebMD, 5/5/08 - "Use of ibuprofen pain relievers like Advil and Motrin for more than five years reduced Alzheimer's risk by 44% in a study reported in the May issue of Neurology"
  • Green tea's Alzheimer protection gets more support - Nutra USA, 4/25/08 - "Polyphenon E (PE) ... The animals receiving the green tea extract should significantly decreased beta-amyloid-induced changes to the reference and working memory, while levels of reactive oxygen species (ROS) were 42 per cent less than the controls animals infused with the protein ... a person (with a body weight of 50 kg) would have to drink about three litres of PE per day to get similar effects ... However, humans consume antioxidants (including vitamins A, B, C and E as well as polyphenols, etc.) from various food sources everyday. Therefore, a lower amount (less than three litres) of 0.5 per cent PE-mixed water volume intake may be effective in humans to ensure the similar effects" - [Abstract] - See green tea extract at Amazon.com.
  • Green tea catechins prevent cognitive deficits caused by Abeta(1-40) in rats - J Nutr Biochem. 2008 Feb 14 - "Polyphenon E (PE) .. PE administration for 26 weeks significantly decreased the Abeta-induced increase in the number of reference and working memory errors, with a concomitant reduction of hippocampal lipid peroxide (LPO; 40%) and cortico-hippocampal reactive oxygen species (ROS; 42% and 50%, respectively). Significantly reduced levels of LPO in the plasma (24%) and hippocampus (25%) as well as those of ROS in the hippocampus (23%) and cortex (41%) were found in the PE+Vehicle group as compared with the Vehicle group ... long-term administration of green tea catechins provides effective prophylactic benefits against Abeta-induced cognitive impairment" - [Nutra USA] - See green tea extract at Amazon.com.
  • Chinese Club Moss Extract (Huperzine A) May Improve Cognition In Alzheimer's Disease - Science Daily, 4/17/08 - "Existing evidence suggests that patients with Alzheimer's disease who have taken Huperzine A have improved general cognitive function, global clinical status, functional performance and reduced behavioural disturbance compared to patients taking placebos" - See huperzine at Amazon.com.
  • Vitamin E May Help Alzheimer's Patients Live Longer, Study Suggests - Science Daily, 4/15/08 - "people who took vitamin E, with or without a cholinesterase inhibitor, were 26 percent less likely to die than people who didn't take vitamin E"
  • Wine May Protect Against Dementia, Study Suggests - Science Daily, 4/10/08 - "among those women who reported that they drank wine a considerably lower proportion suffered from dementia, whereas this correlation was not found among those who had reported that they regularly drank beer or liquor"
  • Cup Of Coffee A Day Could Help Protect Against Alzheimer's Disease, Study Suggests - Science Daily, 4/2/08 - "Caffeine appears to block several of the disruptive effects of cholesterol that make the blood-brain barrier leaky ... High levels of cholesterol are a risk factor for Alzheimer's disease, perhaps by compromising the protective nature of the blood-brain barrier. For the first time we have shown that chronic ingestion of caffeine protects the BBB from cholesterol-induced leakage"
  • Vitamin C can keep you healthy, looking younger - CNN.com, 2/27/08 - "Pairing vitamins C and E is smart for another reason: It may lessen your Alzheimer's risks by as much as 64 percent ..." - See vitamin C products at Amazon.com and and Jarrow FamilE (contains all eight members of the vitamin E family, includes Tocomin) at Amazon.com.
  • Folate Deficiency Associated With Tripling Of Dementia Risk, Study Shows - Science Daily, 2/5/08 - "Folate deficiency is associated with a tripling in the risk of developing dementia among elderly people" - See folic acid at Amazon.com.
  • Late-onset Alzheimer's slowed by DHA omega-3 - Nutra USA, 1/25/08 - "In this study, we report that DHA significantly increases LR11 in multiple systems ... DHA may be most useful for early intervention and prevention of late-onset Alzheimer's disease (LOAD) ... Because reduced LR11 is known to increase beta-amyloid production and may be a significant genetic cause of LOAD, our results indicate that DHA increases in [LR11] levels may play an important role in preventing LOAD" - [Abstract] - See Jarrow Max DHA at Amazon.com.
  • Omega-3 fatty acid docosahexaenoic acid increases SorLA/LR11, a sorting protein with reduced expression in sporadic Alzheimer's disease (AD): relevance to AD prevention - J Neurosci. 2007 Dec 26;27(52):14299-307 - "late-onset Alzheimer's disease (LOAD) ... DHA significantly increases LR11 in multiple systems ... Because reduced LR11 is known to increase Abeta production and may be a significant genetic cause of LOAD, our results indicate that DHA increases in SorLA/LR11 levels may play an important role in preventing LOAD" - See Jarrow Max DHA at Amazon.com.
  • Citrus flavanones show neuroprotection potential - Nutra USA, 1/21/08 - "These results first demonstrate that the citrus flavanones hesperidin, hesperetin, and neohesperidin, even at physiological concentrations, have neuroprotective effects against H2O2-induced cytotoxicity in PC12 cells ... These dietary antioxidants are potential candidates for use in the intervention for neurodegenerative diseases ... One such disease that is mentioned Alzheimer's disease" - [Abstract] - See hesperidin at Amazon.com.
  • Anti-Alzheimer's Mechanism In Omega-3 Fatty Acids Found - Science Daily, 1/2/08 - "the omega-3 fatty acid docosahexaenoic acid (DHA) found in fish oil increases the production of LR11, a protein that is found at reduced levels in Alzheimer's patients and which is known to destroy the protein that forms the "plaques" associated with the disease" - See Jarrow Max DHA at Amazon.com.
  • Fish Oil Prevents Alzheimer's Plaques - WebMD, 12/26/07 - "the fish-oil compound DHA causes brain cells to make lots more LR11 ... Because reduced LR11 is known to increase beta amyloid production and may be a significant genetic cause of late-onset Alzheimer's disease, our results indicate that DHA increases in LR11 levels may play an important role in preventing late-onset Alzheimer's disease" - See Jarrow Max DHA at Amazon.com.
  • Moderate Exercise May Cut Dementia Risk - WebMD,12/19/07- "Moderate physical activity (such as walking and climbing stairs) may help prevent dementia in people aged 65 and older"
  • Moderate beer intake may cut Alzheimer's risk: study - Nutra USA, 12/17/07 - "After three months the researchers report that animals receiving the supplementary silicon, whether from beer or the silicic acid, had significantly lower blood aluminium levels, and higher faecal excretion of aluminium ... The lower blood levels resulted in slower accumulation of aluminium in the tissue, including the brain, which could have benefits for the prevention of Alzheimer's" - See Jarrow BioSil at Amazon.com.  I've been taking about 9 drops of this per day for years.  I stir it with my orange juice every morning.
  • Sugar and Alzheimer's: Are They Linked? - WebMD, 12/7/07 - "The brains of the sugar-fed mice had about twice as many plaque deposits as the mice fed regular water" - [Science Daily]
  • Increased B12 levels could ward off dementia - Nutra USA, 11/16/07 - "The longitudinal cohort study followed 1648 participants for 10 years, and found a doubling in holotranscobalamin (holoTC) concentrations was associated with a 30 per cent slower rate of cognitive decline ... increased levels of the amino acid homocysteine doubled the risk of dementia or cognitive impairment" - [Abstract] - See vitamin B12 at Amazon.com.
  • Low vitamin B-12 status and risk of cognitive decline in older adults - Am J Clin Nutr. 2007 Nov;86(5):1384-91 - "concentrations of holoTC (a marker of reduced vitamin B-12 status), tHcy, and MMA predicted cognitive decline, but folate did not. A doubling in holoTC concentrations (from 50 to 100 pmol/L) was associated with a 30% slower rate of cognitive decline (-0.137 to -0.083), whereas a doubling in tHcy (from 10 to 20 mumol/L) or MMA (from 0.25 to 0.50 mumol/L) was associated with >50% more rapid cognitive decline (-0.090 to -0.169) and (-0.104 to -0.169), respectively" - See vitamin B12 at Amazon.com.
  • Fish for brain health supported by trio of studies - Nutra USA, 11/14/07 - "These recent reports are novel in that they address the association of n-3 fatty acid intake and cognitive function in non-demented individuals and, thus, present a shift in the attention to earlier stages of cognitive decline with the hope of preventing progression to states of dementia and disability before they become irreversible" - See Mega Twin EPA at Amazon.com.
  • Eating Fish, Omega-3 Oils, Fruits And Veggies Lowers Risk Of Memory Problems - Science Daily, 11/13/07 - "people who regularly consumed omega-3 rich oils, such as canola oil, flaxseed oil and walnut oil, reduced their risk of dementia by 60 percent compared to people who did not regularly consume such oils. People who ate fruits and vegetables daily also reduced their risk of dementia by 30 percent compared to those who didn't regularly eat fruits and vegetables ... people who ate fish at least once a week had a 35-percent lower risk of Alzheimer's disease and 40-percent lower risk of dementia, but only if they did not carry the gene that increases the risk of Alzheimer's, called apolipoprotein E4, or ApoE4 ... Given that most people do not carry the ApoE4 gene, these results could have considerable implications in terms of public health" - See Mega Twin EPA at Amazon.com.
  • Low vitamin B-12 status and risk of cognitive decline in older adults - Am J Clin Nutr. 2007 Nov;86(5):1384-91 - "Low vitamin B-12 status was associated with more rapid cognitive decline" - See vitamin B12 at Amazon.com.
  • Cognitive performance among the elderly and dietary fish intake: the Hordaland Health Study - Am J Clin Nutr. 2007 Nov;86(5):1470-8 - "In the elderly, a diet high in fish and fish products is associated with better cognitive performance in a dose-dependent manner" - See Mega Twin EPA at Amazon.com.
  • n 3 Fatty acid proportions in plasma and cognitive performance in older adults - Am J Clin Nutr. 2007 Nov;86(5):1479-85 - "In this population, plasma n-3 PUFA proportions were associated with less decline in the speed-related cognitive domains over 3 y" - See Mega Twin EPA at Amazon.com.
  • Staving Off Alzheimer's Disease With The Right Diet, Prescriptions - Science Daily, 11/7/07 - "Fish oil elevated the level of a protein that prevents the formation of amyloid, the tell-tale protein found in Alzheimer's. Caffeine reversed memory impairment in animal models of the disease. In addition, environmental copper reduced the clearance of amyloid, from the brain to blood ... scientists have identified ways that essential omega-3 fatty acid -- docosahexaenoic acid (DHA) or fish oil -- can help prevent Alzheimer's ... DHA also reduced pro-inflammatory arachidonic acid in brains of Alzheimer's model mice, consistent with the anti-inflammatory effects of non-steroidal anti-inflammatory drugs (NSAIDs) that are associated with reduced Alzheimer's in people" - See Jarrow Max DHA at Amazon.com.
  • Intake of sucrose-sweetened water induces insulin resistance and exacerbates memory deficits and amyloidosis in a transgenic mouse model of Alzheimer's disease - J Biol Chem. 2007 Oct 17 - "controlling the consumption of sugar-sweetened beverages may be an effective way to curtail the risk of developing AD"
  • Mediterranean Diet May Help Alzheimer's Patients Live Longer - Science Daily, 9/10/07 - "Alzheimer's patients who adhered to the diet to a moderate degree lived an average 1.3 years longer than those people who least adhered to the diet. And those Alzheimer's patients who followed the diet very religiously lived an average four years longer"
  • Curry Spice May Counter Alzheimer's - WebMD, 7/16/07 - "In preliminary lab tests, the chemical helped rid the blood of a key ingredient in Alzheimer's brain plaque"
  • Omega-3 Supplements Can Help With Alzheimer's Symptoms, Study Suggests - Science Daily, 6/21/07 - "There was no observable difference in therapeutic effect between the patients receiving the omega-3 and the placebo group. However, when the researchers took into account which of the patients carried the susceptibility gene APOE4 and which did not, an appreciable difference appeared. Carriers of the gene who had received active treatment responded positively to the omega-3 as regards agitation symptoms, while non-bearers of the gene showed an improvement in depressive symptoms" - See Twinlab Mega Twin EPA at Amazon.com or Jarrow Max DHA at Amazon.com.
  • Omega-3 Fatty Acid Slows Alzheimer’s - WebMD, 4/18/07 - "One received supplemental DHA only, and the other two groups received DHA plus additional omega-6 fatty acids ... After three months, all of the mice on the DHA diets had lower levels of beta-amyloid and tau proteins than those in the control group. But at nine months, only those on the DHA-only diet had lower levels of both proteins" - See Jarrow Max DHA at Amazon.com.
  • Omega-3 Fatty Acid May Help Prevent Alzheimer's Brain Lesions - Science Daily, 4/17/07 - "One of these groups received supplemental DHA only, and two groups received DHA plus additional omega-6 fatty acids. After three months, mice in all of the test groups had lower levels of beta amyloid and tau than mice in the control group, but at nine months, only mice on the DHA diet had lower levels of both proteins" - See Jarrow Max DHA at Amazon.com.
  • High Folate Intake May Lower AD Risk - Clinical Psychiatry News, 2/07 - "The risk of AD decreased with increasing intake of folate but not of vitamins B6 or B12"
  • Little Proof That Brain Exercises Slow Mental Decline - Intelihealth, 1/9/07 - "there is little evidence that the brain training programs are worth the time and price"
  • Higher Folate Levels Linked To Reduced Risk For Alzheimer's Disease - Science Daily, 1/9/07 - "Folate, vitamin B12 and vitamin B6, are important in the body's processing of homocysteine--therefore, deficiencies in these nutrients increase homocysteine levels and may contribute to cardiovascular disease, stroke and dementia ... When the individuals were divided into four groups based on the total level of folate they took in through food and supplements and the analysis was adjusted for patient characteristics, comorbid diseases and B12 and B6 intake, the risk of Alzheimer's disease was lower in the groups with higher intake" - See iHerb or Vitacosticon folic acid products.
  • Can Fish Intake Predict Chances Of Developing Dementia? - Science Daily, 1/3/07 - "the participants who reported consuming an average of about three servings of oily fish a week--equivalent to blood levels of DHA at 180 milligrams daily--were associated with a significantly reduced risk of developing dementia of all types, including Alzheimer's disease. No other fatty acid blood level was independently linked to the risk of dementia" - See Jarrow Max DHA at Amazon.com.
  • There's Hope in the Drug Pipeline [for Alzheimer's] - US News, 12/11/06 - "A compound called huperzine A seems to combine some memory-saving effects of drugs like Aricept and Namenda with an ability to protect neurons from beta amyloid. It's currently being tested for safety and effectiveness in people" - See iHerb or Vitacost huperzine A products.
  • Higher Level Of Certain Fatty Acid Associated With Lower Dementia Risk - Science Daily, 11/28/06 - "men and women in the quartile with the highest DHA levels had a 47 percent lower risk of developing dementia and 39 percent lower risk of developing Alzheimer's disease than the other three quartiles with lower DHA levels ... those in the top quartile of blood DHA levels reported that they ate an average of .18 grams of DHA a day and an average of three fish servings a week. Participants in the other quartiles ate substantially less fish" - See iHerb or Vitacosticon DHA products.  My favorite is Jarrow Max DHA at Amazon.com.
  • B-vitamins reduce plasma levels of beta amyloid - Neurobiol Aging. 2006 Nov 17 - "Elevated plasma homocysteine (tHcy) is a risk factor for Alzheimer's disease (AD), and thus B vitamins may have a role in the prevention of AD. The objective of this study was to determine if tHcy lowering vitamins decrease the circulating levels of A-beta protein 1-40 (Abeta40). We randomized 299 older men to treatment with 2mg of folate, plus 25mg of B6 and 400mug of B12, or placebo. After 2 years of treatment the mean (S.E.) increase of Abeta40 was 7.0pg/ml (8.4) in the vitamin group (4.9%), and 26.8pg/ml (7.7) (18.5%) in the placebo group. We conclude that B vitamins may decrease the plasma level of Abeta40 and have a role in the prevention of AD"
  • Fat in Fish May Help Prevent Dementia - WebMD, 11/13/06 - "participants with the highest DHA levels at the beginning of the study were 47% less likely to get dementia and 39% less likely to get Alzheimer's disease during the study than the rest of the group" - See iHerb or Vitacosticon DHA products.  My favorite is Jarrow Max DHA at Amazon.com.
  • Plasma Phosphatidylcholine Docosahexaenoic Acid Content and Risk of Dementia and Alzheimer Disease: The Framingham Heart Study - Arch Neurol 2006;63 1545-1550 - "Subjects in the upper quartile of plasma PC DHA levels had a mean DHA intake of 0.18 g/d and a mean fish intake of 3.0 servings per week ... The top quartile of plasma PC DHA level was associated with a significant 47% reduction in the risk of developing all-cause dementia"
  • Can caffeine protect against Alzheimer's? - USA Today, 11/5/06 - "Lesko and others are betting on research suggesting that caffeine will offer protection not just against Alzheimer's, but also against Parkinson's ... Alzheimer-stricken mice that had guzzled caffeine could easily find their way through a maze. Mice that got just water had more signs of brain disease and got confused in the maze"
  • {omega}-3 Fatty Acid Treatment in 174 Patients With Mild to Moderate Alzheimer Disease: OmegAD Study: A Randomized Double-blind Trial - Arch Neurol. 2006 Oct;63(10):1402-8 - "Administration of omega-3 fatty acid in patients with mild to moderate AD did not delay the rate of cognitive decline according to the MMSE or the cognitive portion of the Alzheimer Disease Assessment Scale. However, positive effects were observed in a small group of patients with very mild AD (MMSE >27 points)"
  • Omega-3 Fatty Acids May Slow Cognitive Decline In Some Patients With Very Mild Alzheimer's Disease - Science Daily, 10/11/06 - "For six months, 89 patients (51 women and 38 men) took 1.7 grams of docosahexaenoic acid (DHA) and .6 grams of eicosapentaenoic acid (EPA), while 85 patients (39 women and 46 men) took placebo ... among a subgroup of 32 patients with very mild cognitive impairment at the beginning of the study, those who took the fatty acids experienced less decline in six months compared with those who took placebo" - See Mega Twin EPA at Vitacosticon or iHerb.
  • Diet May Influence Alzheimer's Risk - WebMD, 10/9/06 - "Long suspected of lowering the risk of heart disease and diabetes, the Mediterranean diet consists of large amounts of fruits, vegetables, beans, grains, and nuts. Red meats are eaten only rarely and poultry, eggs, and dairy products are eaten in moderation. Olive oil and fatty fish are the main sources of fat in the diet ... People who most closely adhered to the diet had an Alzheimer's risk that was 40% to 65% lower than people who were least likely to follow the diet"
  • Chemical Found In Curry May Help Immune System Clear Amyloid Plaques Found In Alzheimer's Disease - Science Daily, 10/3/06 - "curcumin -- a chemical found in curry and turmeric -- may help the immune system clear the brain of amyloid beta, which form the plaques found in Alzheimer's disease" - See iHerbor Vitacosticon curcumin products.
  • Red Wine May Prevent Alzheimer's - WebMD, 9/20/06 - "After seven months of sipping their designated drinks, the mice individually were placed in a maze and challenged to find their way out ... Those in the red wine group performed best. The mice in the ethanol group weren't better at mastering the maze than the teetotalers ... The mice in the red wine group were quicker to adapt to that change"
  • Drinking Juice May Stall Alzheimer's - WebMD, 8/31/06 - "people who drank fruit and vegetable juices more than three times a week were 76% less likely to develop Alzheimer's disease than those who drank juices less than once a week"
  • Calorie Restriction May Prevent Alzheimer's Through Promotion Of Longevity Program In The Brain - Science Daily, 6/14/06 - "a high caloric intake based on saturated fat promotes AD type beta-amyloidosis, while caloric restriction based on reduced carbohydrate intake is able to prevent it"
  • Novel Strategy to Restore Brain Cell Function - Life Extension Magazine, 5/06 - "Alzheimer’s patients taking 300 mg of phosphatidylserine daily performed significantly better on standardized memory tests at the end of the 12-week trial period than did the study participants who received placebo. Importantly, those patients who were the least afflicted by dementia demonstrated the greatest benefit from phosphatidylserine therapy. These results suggest that beginning supplementation very early on, or perhaps even before the appearance of symptoms, can help prevent age-related loss of memory and other cognitive impairments"
  • Mediterranean Diet May Cut Alzheimer's - WebMD, 4/18/06 - "Scores ranged from 0-9, with higher scores showing greater adherence to a Mediterranean diet ... those with middle scores were 15% less likely to have been found to have developed Alzheimer's disease, and those with the highest scores were 40% less likely to have been found to have Alzheimer's disease"
  • Can Exercise Protect Against Alzheimer’s? - Physician's Weekly, 4/17/06 - "the rate of dementia development was significantly lower for those who exercised at least three days a week"
  • Regular Exercise May Delay Alzheimer's - WebMD, 1/17/06
  • Staying active helps keep the mind sharp - MSNBC, 1/16/06 - "healthy people who reported exercising regularly had a 30 to 40 percent lower risk of dementia"
  • Does Green Tea Ingredient Protect Against Alzheimer’s? - Physician's Weekly, 11/28/05 - "The results suggest that an EGCG dietary supplement may help in preventing the disease in the future"
  • High-Fat, Low-Carb Diet May Help Alzheimer's - WebMD, 10/18/05
  • Low Vitamin E Serum Levels Correlate With Dementia Risk - Clinical Psychiatry News, 10/05 - "those individuals in the bottom tertile of vitamin E plasma levels were at significantly higher risk not only of being demented (OR 2.6, 95% CI) but also of having impaired cognitive function (OR 2.2, 95% CI), compared with the highest vitamin E tertile"
  • Fish Fights Aging in the Brain - WebMD, 10/10/05 - "eating fish at least once a week slowed the rate of mental or cognitive decline in elderly people by 10%-13% per year ... Researchers attribute the protective effects of fish on the brain to omega-3 fatty acids" - See Mega Twin EPA at Vitacosticon or iHerb.
  • Obesity at Midlife Raises Dementia Risk Later - WebMD, 10/10/05 - "people who were obese at midlife were nearly 2.5 times more likely to develop dementia more than 20 years later than those who were normal weight ... high blood pressure and total cholesterol levels at midlife also doubled the risk of dementia in later life ... when a person had all three of these risk factors at midlife, the risk of dementia or Alzheimer's disease was six times higher"
  • Preserving and Restoring Brain Function - Life Extension Magazine, 10/05 - "Clinical trials using small groups of patients with cognitive decline demonstrated significant improvements with phosphatidylserine supplementation, especially among patients in the early stages"
  • Antioxidant in Green Tea May Fight Alzheimer's - WebMD, 9/20/05 - "high doses of the green tea ingredient -- known as epigallocatechin-3-gallate (EGCG) -- significantly reduced the formation of beta-amyloid proteins in the brains of mice that were altered to develop Alzheimer's disease" - See iHerb or Vitacosticon green tea products.
  • Fatty Acids: Good For The Brain, Good For Alzheimer Disease - Science Daily, 9/11/05 - "DHA can decrease levels of the pathogenic Abeta peptides that are associated with Alzheimer disease pathology in human brain cells"
  • Scientists Discover How Fish Oil Protects the Brain - Intelihealth, 9/9/05 - "docosahexaenoic acid, an omega-3 fatty acid found in coldwater fish such as mackerel, sardines and salmon, reduces levels of a protein known to cause damaging plaques in the brains of Alzheimer's patients"
  • Fish Fat May Help Fight Alzheimer's Disease - WebMD, 9/8/05 - "DHA helped brain cells in two ways: ... Curbing production of beta-amyloid proteins, which are seen in Alzheimer's brain plaque ... Boosting production of another protein called NPD1 that helps brain cells stay alive" - See iHerb or Vitacosticon DHA products.  My favorite is Jarrow Max DHA at Amazon.com.
  • Folates More Effective In Limiting Alzheimer's Disease Risk Than Antioxidants, Other Nutrients - Science Daily, 8/17/05 - "folates appear to have more impact on reducing Alzheimer's risk than vitamin E, a noted antioxidant, and other nutrients considered for their effect as a brain-aging deterrent" - See iHerb or Vitacosticon folic acid products.
  • Folate May Reduce Risk of Alzheimer's Disease - WebMD, 8/15/05 - "older adults whose total folate intake (diet and supplement) equaled or exceeded the 400 microgram RDA reduced their chances of developing Alzheimer's disease by 55%" - See iHerb or Vitacosticon folic acid products.
  • Complementary and Integrative Approaches to Dementia - Medscape, 7/5/05 - "Ginkgo biloba, an herbal product long used in traditional Chinese medicine, has been studied extensively and found to be well tolerated with mild benefit, approximating that of the 2nd generation cholinesterase inhibitors ... Huperzine A is a potent plant-based alkaloid with reversible acetylcholinesterase-inhibitory ... There have been several controlled clinical trials suggesting that ALc slows the progression of AD" - See acetyl l-carnitine at Amazon.com, ginkgo biloba at Amazon.com and huperzine A at Amazon.com.
  • Alzheimer's Risk May Be Cut - washingtonpost.com, 6/20/05 - "Middle-aged sons and daughters of people with Alzheimer's disease may be able to reduce their risk of getting the disorder through lifestyle measures such as exercise, avoiding gum disease, moderate alcohol consumption and drinking fruit and vegetable juice"
  • Fish Oil Holds Promise In Alzheimer's Fight - Science Daily, 5/29/05 - "one group of the mice DHA-fortified chow ... After three to five months--the equivalent of several years in human biology--the high-DHA group had 70-percent less buildup of amyloid protein in the brain" - See iHerb or Vitacosticon DHA products.  My favorite is Jarrow Max DHA at Amazon.com.
  • Preventing Age-Related Cognitive Decline - Life Extension Magazine, 4/05 - "Free radicals are a significant culprit, interfering with energy metabolism, blood flow, and nerve structure and function. Mitochondrial energy boosters, vitamins, hormones, and other antioxidants are effective weapons in the war against oxidative stress, safely enhancing energy production and blood flow, suppressing inflammation, maintaining the structural integrity of nerve cell components, and facilitating neuronal activity"
  • Vitamin E From Food Sources May Reduce Risk of AD - Medscape, 2/11/05 - "High intake of vitamin E from food (tocopherol), but not from supplements (which usually contain α-tocopherol), is inversely associated with Alzheimer disease ... various tocopherol forms rather than α-tocopherol alone may be important in the vitamin E protective association with Alzheimer disease"
  • Do Carbs, Calories Affect Alzheimer's Risk? - WebMD, 1/13/05 - "mice eating fewer calories and carbohydrates than those allowed to eat all they wanted showed no signs of Alzheimer's-like disease, even though they had been bred to have the condition"
  • Curry Spice May Fight Alzheimer's Disease - WebMD, 1/5/04 - "the curry pigment curcumin slows the formation of, and even destroys, accumulated plaque deposits in mouse brains"
  • DHA Protects Against Alzheimer’s Disease? - Physician's Weekly, 1/3/05 - "DHA intake should be considered as a potential neuroprotective strategy for AD" - See iHerb or Vitacosticon DHA products.  My favorite is Jarrow Max DHA at Amazon.com.
  • Fewer Calories Could Slow Alzheimer’s - Science Daily, 12/24/04 - "Restricting the diets of mice reduces the build-up of plaques in the brain that are linked to Alzheimer’s disease"
  • Low-Fat Diet May Protect Against Alzheimer's - WebMD, 12/7/04 - "mice fed a low-fat diet rich in the omega-3 fatty acids found in fish and soy, produced more of a protein that helps eliminate the amyloid peptides that cause plaque in the brain"
  • Food for thought: Can diet protect memory? - MSNBC, 12/6/04 - "research increasingly suggests that diet may be important in preventing Alzheimer's ... older dogs fed a diet rich in antioxidants over several years were able to perform tasks — and learn new tricks — far better than fellow canines fed a normal diet ... scientists believe that curcumin, a spice used in India and known for its anti-inflammatory effects, may prevent memory loss"
  • Good for the heart, good for the brain - MSNBC, 12/6/04 - "While diets high in cholesterol are bad for the brain, getting plenty of omega 3 fatty acids, found primarily in fish, is vital for a healthy noggin ... In particular, a component of omega 3 fatty acids known as DHA, or docosahexaenoic acid, is key"
  • Can Curcumin Prevent Alzheimer's Disease? - Life Extension Magazine, 12/04
  • Apples May Ward Off Alzheimer's Disease - WebMD, 11/18/04 - "The results suggest that quercetin "contributes significantly" to the protection of brain cells from free radicals in conditions like Alzheimer's disease" - See iHerb or Vitacosticon quercetin products.
  • Mental Exercises Slow Alzheimer's Disease - WebMD, 10/27/04
  • Black, Green Tea May Slow Alzheimer's Disease - WebMD, 10/27/04
  • A Pill to Prevent Alzheimer's? - Dr. Weil, 9/30/04
  • Testosterone Loss May Raise Alzheimer's Risk - WebMD, 9/24/04 [Science Daily] - "testosterone levels were significantly lower in the men with Alzheimer's disease compared with the men who did not have the disease ... the findings are significant because only testosterone levels appeared related to Alzheimer's risk ... It protects neurons from injury, and it reduces levels of beta-amyloid, the protein widely implicated as a causal factor in the disease"
  • Physical Activity, Including Walking, Associated With Better Mental Functioning in Older Women - Doctor's Guide, 9/22/04 - "higher levels of physical activity, including walking, are associated with better cognitive function and less cognitive decline"
  • Walking May Protect Elderly Men From Dementia, New Study By U. Va. Researcher Shows - Science Daily, 9/22/04 - "Elderly men who are sedentary or walk less than a quarter of a mile per day are nearly twice as likely to develop dementia and Alzheimer's disease compared to men who walk more than two miles per day"
  • Long-Term Use of Beta Carotene Beneficial - Clinical Psychiatry News, 9/04 - "there was a highly significant improvement in cognitive scores—particularly in verbal memory—among the 2,029 men with long-term exposure to the supplements, compared with the 2,020 who had been taking placebo for nearly two decades"
  • Lifestyle Changes Could Cut Alzheimer's Cases - HealthDay, 9/9/04 - "he put 10 people on a lifestyle program that includes mental exercise, physical exercise, stress reduction, and a "healthy brain" diet, including such foods as fish that are rich in healthy fats ... In just two weeks, 75 percent of those on the program had a 20 to 30 percent improvement in memory scores"
  • Why Fish Seems to Prevent Alzheimer's Damage - WebMD, 9/1/04 - "DHA may prevent or slow Alzheimer's progression by protecting against damage to the area where brain cells communicate" - See iHerb or Vitacosticon DHA products.  My favorite is Jarrow Max DHA at Amazon.com.
  • Diet, Activity May Help Prevent Alzheimer's - WebMD, 7/19/04 - "eating vegetables (especially broccoli or spinach), staying active mentally and socially, and keeping a trim waistline can all help prevent or delay Alzheimer's disease"
  • Curry May Protect Aging Brain - WebMD, 4/19/04 - "Small doses of curry could help protect the brain against Alzheimer's disease -- at least that's the effect in rats" - See iHerbor Vitacosticon curry products.
  • Memory enhancer named best new ingredient - Functional Foods and Nutraceuticals, 4/04 - "Citicoline is a form of choline that helps replenish the brain with phosphatidylserine ... In a double-blind trial of 84 elderly patients with mild to moderate memory loss, subjects who took 1000mg of citicoline daily for six weeks showed improvement in the acquisition of new information and its recall and improvement in global memory efficiency" - See Vitacosticon citicoline products.
  • Vitamins to Prevent Alzheimer’s? - Dr. Weil, 3/15/04
  • Health Benefits of Folic Acid - PowerPak.com (CME), exp. 11/15/05 - "there is growing evidence to suggest that folic acid supplementation may be beneficial in patients with depression, as well as those with dementia and Alzheimer's disease"
  • High DHA Intake Linked to Less Alzheimer's, Other Dementia - Clinical Psychiatry News, 3/04 - "People who ate an average of 180 mg or more a day of docosahexaenoic acid (DHA), a fatty acid found in fish oil, had about 40% less Alzheimer's disease and other dementia, compared with people who consumed less DHA" - See iHerb or Vitacosticon DHA products.  My favorite is Jarrow Max DHA at Amazon.com.
  • Vitamin Supplement Use May Reduce Effects Of Alzheimer's Disease - Doctor's Guide, 1/20/04
  • Vitamins C and E May Lower Alzheimer's Risk - WebMD, 1/20/04
  • Reduced Risk of Alzheimer Disease in Users of Antioxidant Vitamin Supplements - Arch Neurol. 2004;61:82-88 - "Conclusions Use of vitamin E and vitamin C supplements in combination is associated with reduced prevalence and incidence of AD. Antioxidant supplements merit further study as agents for the primary prevention of AD"
  • Chelation Therapy May Ease Alzheimer's - WebMD, 12/15/03
  • Eat Your B's - Wellness Insider, 11/25/03 - "In the elderly population, B12 deficiencies are not uncommon and can result in an impaired cognitive state that closely mimics Alzheimer's disease" - See iHerb or Vitacosticon Vitamin B12 products.
  • Fish And N-3 Fatty Acids Reduce Risk Of Alzheimer’s Disease - Life Extension Foundation, 11/03 - "A new study, from the Rush-Presbyterian, St. Lukes Medical Center, in Chicago, shows that people who consumed at least one serving of fish a week dramatically reduced their risk of Alzheimer’s disease, compared to those who rarely or never ate fish. Dietary intake of omega-3 fatty acids had a similar risk-lowering effect" - See Mega Twin EPA at Vitacosticon or  iHerb.
  • Leisure Activity May Prevent Alzheimer's - WebMD, 10/2/02
  • Antioxidants May Protect Women From Alzheimer's - Clinical Psychiatry News, 10/03 - "Compared with women in the lowest quartile of overall antioxidant consumption, those in the highest quartile had an OR of 0.39 for Alzheimer's disease ... When their diets were analyzed for specific antioxidants, women who consumed the most vitamin C and lycopene also had a significantly lower risk of cognitive decline"
  • Prevent Alzheimer's With Healthy Living - WebMD, 9/12/03 - "The same risk factors linked to heart disease and stroke -- high blood pressure, high cholesterol, sedentary lifestyle, smoking, and diabetes -- also increase the risk of Alzheimer's disease ... statins, and in particular, Lipitor, help destroy the other telltale sign of Alzheimer's disease -- increased levels of amyloid, a sticky substance not unlike cholesterol that forms plaques in the brain ... Deal with depression, now ... Try to limit "free radical" damage"  - Note:  Red yeast rice is a non-prescription statin.  See iHerb or Vitacosticon red yeast rice products.
  • Herb Sage Improves Memory - WebMD, 8/28/03 - "44 healthy, young adults took either sage oil capsules or a placebo. The participants then took a series of word recall tests ... The people who had taken the sage oil consistently had better word recall -- a sign that sage may help improve memory ... sage's antioxidant and anti-inflammatory properties could be valuable in Alzheimer's treatment" - See iHerb or Vitacosticon sage products.
  • Study Supports Potential of Nonsteroidal Anti-inflammatory Drugs to Protect Against Alzheimer's - Doctor's Guide, 7/22/03 - "The pooled combined data from the cohort and case-control studies showed a relative risk of Alzheimer's disease was 0.72 among NSAID users ... The analysis specific to aspirin users included eight studies that showed a pooled relative risk of 0.87 for developing Alzheimer's disease"
  • Fish Once a Week Cuts Alzheimer's Risk - WebMD, 7/21/03 - "Weekly fish eaters had a 60% lower risk of Alzheimer's than people who rarely or never ate fish ... The beneficial effects of [fatty acids] from fish may be counterbalanced by toxins ... A high antioxidant/low saturated fat diet pattern with a greater amount of fish, chicken, fruits, and vegetables and less red meat and dairy products is likely to lower the risk of AD, as well as that for heart disease and stroke ... Furthermore, B vitamin supplements, containing vitamins B12 and B6 and folic acid, lower plasma total homocysteine levels, possibly decreasing the risk of stroke, heart disease and perhaps Alzheimer's disease" - See Mega Twin EPA at Vitacosticon or  iHerb.
  • Disappointing Data Confound Claims For DHEA Effectiveness [against Alzheimer's] - Psychiatric News, 6/6/03 - "Twenty-eight patients were blindly chosen to receive 50 mg of DHEA twice a day for six months ... The dose of DHEA, Wolkowtiz said, was targeted to achieve blood levels of the hormone at or slightly above the top of the normal range of DHEA levels found in healthy young adults ... numerically, DHEA did have a benefit on cognitive ratings, but overall, on the CIBIC-Plus, there was no significant benefit shown ... at three months, the DHEA group, compared with placebo, showed a trend toward improvement on the ADAS-Cog, but the improvement only narrowly missed being statistically significant ... DHEA has been reported to reduce cortisol, the so-called "stress hormone," which in response to stress is released in large quantities that have been linked to neuronal stress and damage" -  Does anyone detect bias in that title?  I don't know if DHEA helps Alzheimer's or not but I feel the title should have been something like "Alzheimer's Shows Trend Toward Improvement with DHEA at 3 Months".  Their attitude seems to be that nothing works except what we write prescriptions for.  The way I understand it, Alzheimer's usually gets worse, not better and cholinesterase inhibitors slow the disease, they don't reverse it and three months is a short time to determine if it is working.  For example, see the following  in the same issue of Clinical Psychiatry News.  See iHerb or Vitacosticon DHEA products. - Ben
  • NSAIDs May Protect Against Alzheimer's - Clinical Psychiatry News, 6/03 - "Long-term use of NSAIDs—24 months or longer—was associated with a significant protective effect"
  • NSAIDs No Help as Alzheimer's Treatment - WebMD, 6/3/03 - "Aisen's team tested the two drugs in 351 patients with mild-to-moderate Alzheimer's disease. They looked for signs that the drugs might slow mental decline or improve quality of life ... There was "no consistent benefit of either treatment,""
  • Novelty Seeking Tied to Lower Alzheimer's Risk - Clinical Psychiatry News, 6/03
  • Hyperhomocysteinemia and Vitamin Score: Correlations with Silent Brain Ischemic Lesions and Brain Atrophy - Dementia and Geriatric Cognitive Disorders 2003;16:39-45 - "In subjects with minor brain ischemic lesions (n = 21), tHcy was higher by 5.6 µM, whereas vitamin score and cognitive function were lower than in controls"
  • NSAIDs and Amyloid Plaques Have Close Relationship - Psychiatric News, 5/2/03
  • Plasma vitamin C, cholesterol and homocysteine are associated with grey matter volume determined by MRI in non-demented old people - Neurosci Lett 2003 May 8;341(3):173-6 - "We found that lower grey matter volume was associated with lower plasma vitamin C and higher homocysteine, cholesterol and LDL. Lower blood cell folate was also associated with lower grey matter volume ... These data are consistent with the putative benefits of dietary vitamin C and folate intake and the role of cholesterol in age related neurodegeneration"
  • Non-Steroidal Anti-Inflammatory Drugs Appear To Protect Against Alzheimer's - Doctor's Guide, 4/1/03 - "compared with non-users, people who took any type of NSAID were 28% less likely to develop Alzheimer's, which was statistically significant. But, among aspirin-only users, the risk of Alzheimer's was cut by 13%, which was not significant" - See ibuprofen at Amazon.com and aspirin at Amazon.com.
  • NSAIDS May Help in Alzheimer's Prevention - WebMD, 4/1/03 - "For those using aspirin, the reduction in risk was 13%, a finding that was not considered significant ... Those on an NSAID for one to 23 months had a risk reduction of 17%, and those termed long-term users, beyond 23 months, reduced the risk of developing Alzheimer's disease by 73%" - See ibuprofen at Amazon.com and aspirin at Amazon.com.
  • High-dose antioxidant supplements and cognitive function in community-dwelling elderly women - Am. J. of Clin. Nutr., 4/03 - "Long-term, current users of vitamin E with vitamin C had significantly better mean performance, as judged by a global score that combined individual test scores, than did women who had never used vitamin E or C (P = 0.03); there was a trend for increasingly higher mean scores with increasing durations of use (P = 0.04). These associations were strongest among women with low dietary intakes of alpha-tocopherol. Benefits were less consistent for women taking vitamin E alone, with no evidence of higher scores with longer durations of use. Use of specific vitamin C supplements alone had little relation to performance on our cognitive tests"
  • Cognitive decline and fatty acid composition of erythrocyte membranes - Am. J. of Clinical Nutr., 4/03 - "studied the relation between erythrocyte membrane fatty acid composition and cognitive decline in free-living volunteers ... Higher proportions of both stearic acid (saturated, 18:0) and total n-6 polyunsaturated fatty acids were associated with greater risk of cognitive decline ... Conversely, a higher proportion of total n-3 fatty acids was associated with a lower risk of cognitive decline"
  • Alzheimer's Disease and Dementia: Vitamins Can Help Prevent - WebMD, 2/28/03 - "High levels of a substance in the blood called homocysteine tops the list of potentially new risk factors for heart disease, stroke, and now dementia. A new study suggests that high homocysteine levels are linked with mental declines associated with Alzheimer's disease in elderly people ... High homocysteine levels can be treated very easily with vitamins, including folate, niacin, and B-12"
  • Dietary Fats and the Risk of Incident Alzheimer Disease - Archives of Neurology, 2/03 - "Intakes of saturated fat and trans-unsaturated fat were positively associated with risk of Alzheimer disease, whereas intakes of -6 polyunsaturated fat and monounsaturated fat were inversely associated. Persons in the upper fifth of saturated-fat intake had 2.2 times the risk of incident Alzheimer disease compared with persons in the lowest fifth" - See the tables on my fatty acids page.  For example, palm oil is 51% saturated fat while canola oil is 8% saturated.
  • NSAID Use Linked to Lower Incidence of Alzheimer's - Clinical Psychiatry News, 1/03 - "The largest reduction in risk was among former users of NSAIDs or aspirin who had taken the medications for 2 years or more. The incidence of Alzheimer's disease in that group was 29% of the rate seen in nonusers"
  • Eating Fish May Prevent Dementia and Alzheimer’s Disease - New Hope Natural Media, 12/12/02 - "People who consumed fish or seafood at least once a week reduced their risk of developing dementia and Alzheimer’s disease by 34% and 31%, respectively, compared with those who never ate fish ... Nutritional supplements that may help slow the progression of dementia or AD include acetyl-L-carnitine, vitamin E, thiamine (vitamin B1), melatonin, Ginkgo biloba and Huperzine A"
  • Ginkgo for Alzheimer's Disease - Clinical Psychiatry News, 12/02 - "A 4-point gain on the ADAS-Cog is roughly equivalent to a 6-month delay in disease progression. “It is noteworthy that 29% of the patients with Alzheimer's disease treated with EGb for at least 26 weeks improved by 4 or more points, compared with 13% treated with the placebo,” ... In a German multicenter study, 156 patients with Alzheimer's or multi-infarct dementia were randomized to 240 mg/day of EGb 761 or placebo; efficacy was assessed by three validated scales. By the end of the 24-week study, 28% of patients in the ginkgo group were classified as responders, compared with 10% in the placebo group, a significant difference" - I've got that, see ginkgo biloba at Amazon.com.
  • Bright Light, Aromatherapy Ease Dementia - WebMD, 12/5/02
  • Iron Deficiency Harms Brain - WebMD, 11/8/02 - "Too little iron may be the cause of at least some cases of Alzheimer's disease ... As people age, their red blood cells have less of the stuff that makes them red. It's called heme, a cellular form of iron ... It's fairly common for people to get too little iron or vitamin B6 in their diets. Exposure to aluminum or other toxic metals is also quite common. All these things block heme in brain cells" - See iHerb and Vitacosticon iron products.
  • Eating Fish Cuts Risk of Dementia - WebMD, 10/24/02 - "Those who ate fish or seafood at least once a week had a significantly lower risk of being diagnosed with dementia during the seven-year study period ... The fatty acids in fish oils provide protection for arteries, which could improve blood flow to the brain. In addition, the fatty acids may reduce inflammation in the brain. They may also have a specific role in brain development and regeneration of nerve cells, the authors suggest" - See Twinlab Mega Twin EPA at Amazon.com  or Vitacosticon.
  • Further Evidence Of Fish Consumption Link To Lower Alzheimer Risk - Doctor's Guide, 10/24/02
  • Antioxidants May Reduce Alzheimer's Disease Risk - Clinical Psychiatry News, 10/02 - "Use of vitamins E and C together—which is what most subjects did—was associated with an eightfold reduction in prevalence and a fivefold lower incidence of Alzheimer's disease"
  • More Antioxidants, Less Fat May Reduce Alzheimer's Risk - Clinical Psychiatry News, 10/02 - "Data are now strong enough to recommend a dietary strategy for reducing Alzheimer's disease (AD) risk that includes low fat intake and high consumption of fish and antioxidants, along with vitamin E, folic acid, and vitamins B6 and B12 supplements"
  • MEDLINE Abstracts: Antioxidants and the Aging Brain - Medscape, 9/27/02 - "Combinations of antioxidants might be of even greater potential benefit for AD, especially if the agents worked in different cellular compartments or had complementary activity (e.g. vitamins E, C and ubiquinone). Naturally-occurring compounds with antioxidant capacity are available and widely marketed (e.g. vitamin C, ubiquinone, lipoic acid, beta-carotene, creatine, melatonin, curcumin) and synthetic compounds are under development by industry" - Again, a broad spectrum of anti-oxidants, not just one or two.
  • Exercise, Eating to Enhance Memory? - Dr. Weil, 9/26/02 - "We know that the incidence of Alzheimer’s is higher than normal among people whose diets are high in saturated fat, which causes free radical damage leading to inflammation of the brain. On the other hand, omega-3 fatty acids found in salmon, sardines and flax seeds appear to be protective. Blueberries are another food that seems to help ... Dr. Khalsa explains that in addition to age, chronic stress can harm the hippocampus via the release of high levels of the hormone cortisol from the adrenal gland"
  • Pain Relievers May Prevent Alzheimer's - WebMD, 9/23/02 - "The study found people who took aspirin or other NSAIDs for more than two years before the study began were 45% less likely to develop Alzheimer's than those who didn't. And the longer the participants had taken the drugs, the more protected they were against the disease ... previous studies have suggested that aspirin and other NSAIDs might protect against Alzheimer's disease by reducing inflammation in the brain ... their findings show that the beneficial effects of NSAIDs in preventing Alzheimer's take a long time to accumulate and don't become apparent until years later"

Other News:

  • Flu may boost Alzheimer's risk, research suggests - MSNBC, 2/16/12 - "Viruses such as influenza and herpes may leave brain cells vulnerable to degeneration later in life, and increase the risk of developing diseases such as Alzheimer's and Parkinson's, research suggests. That's because these the viruses can enter the brain and trigger an immune response — inflammation — which can damage brain cells"
  • Diabetes linked to cognitive impairment in older adults, study suggests - Science Daily, 11/8/11 - "in older patients with diabetes, two adhesion molecules -- sVCAM and sICAM -- cause inflammation in the brain, triggering a series of events that affect blood vessels and, eventually, cause brain tissue to atrophy. Importantly, they found that the gray matter in the brain's frontal and temporal regions -- responsible for such critical functions as decision-making, language, verbal memory and complex tasks -- is the area most affected by these events ... at the age of 65, the average person's brain shrinks about one percent a year, but in a diabetic patient, brain volume can be lowered by as much as 15 percent ... Diabetes develops when glucose builds up in the blood instead of entering the body's cells to be used as energy. Known as hyperglycemia, this condition often goes hand-in-hand with inflammation ... Once chronic inflammation sets in, blood vessels constrict, blood flow is reduced, and brain tissue is damaged"
  • Mood, cognition and sleep patterns improve in Alzheimer's patients after cataract surgery, study finds - Science Daily, 10/25/11
  • Diabetes may significantly increase the risk of dementia - Science Daily, 9/19/11 - "people with diabetes were twice as likely to develop dementia as people with normal blood sugar levels ... the risk of developing dementia significantly increased when blood sugar was still high two hours after a meal"
  • Link between high cholesterol and Alzheimer's disease revealed in new study - Science Daily, 9/12/11 - "high cholesterol levels were significantly related to brain plaques associated with Alzheimer's disease ... the cholesterol levels were tested for 2,587 people age 40 to 79 who had no signs of Alzheimer's disease. Then they examined 147 autopsied people who died after a long observation period (10 to 15 years) ... People with high cholesterol levels, defined by a reading of more than 5.8 mmol/L, had significantly more brain plaques when compared to those with normal or lower cholesterol levels. A total of 86 percent of people with high cholesterol had brain plaques, compared with only 62 percent of people with low cholesterol levels ... insulin resistance, a sign of diabetes, may be another risk factor for brain plaques associated with Alzheimer's disease"
  • Humans Alone See Brains Shrink With Age, Researchers Find - WSJ, 7/26/11 - "they found the human brains lost significant volume over time, while the chimpanzees didn't ... Stress can affect brain size. So can depression, research shows. Diet can be a factor, too. More broadly, though, humanity's unusual shrinking brain just may be the price our species pays for living so much longer than other primates ... During those extra decades of life, natural cell-repair mechanisms may wear out and neural circuits wither, the researchers said. As the brain normally ages, it acquires the neural equivalent of sore knees and stiff fingers. Natural grooves in the brain widen. Healthy swellings subside. And tangles of damaged neurons become dense thickets of dysfunctional synapses"
  • Hemoglobin level in older persons and incident Alzheimer disease: Prospective cohort analysis - Neurology. 2011 Jul 13 - "When compared to participants with clinically normal hemoglobin (n = 717), participants with anemia (n = 154) had a 60% increased hazard for developing AD (95% CI 1.02-2.52), as did participants with clinically high hemoglobin (n = 10, HR 3.39, 95% CI 1.25-9.20). Linear mixed-effects models showed that lower and higher hemoglobin levels were associated with a greater rate of global cognitive decline (parameter estimate for quadratic of hemoglobin = -0.008, SE -0.002, p < 0.001). Compared to participants with clinically normal hemoglobin, participants with anemia had a -0.061 z score unit annual decline in global cognitive function (SE 0.012, p < 0.001), as did participants with clinically high hemoglobin (-0.090 unit/year, SE 0.038, p = 0.018) ... In older persons without dementia, both lower and higher hemoglobin levels are associated with an increased hazard for developing AD and more rapid cognitive decline"
  • Stress may increase risk for Alzheimer's disease - Science Daily, 5/26/11 - "Fewer than ten percent of Alzheimer cases have a genetic basis. The factors that contribute to the rest of the cases are largely unknown ... life events (stress) may be one trigger ... stress, and the hormones released during stress, can accelerate the development of Alzheimer disease-like biochemical and behavioural pathology"
  • Plasma homocysteine and cognitive decline in older hypertensive subjects - Int Psychogeriatr. 2011 May 6:1-9 - "Higher homocysteine showed an independent association with greater cognitive decline in three domains: speed of cognition (β = -27.33, p = 0.001), episodic memory (β = -1.25, p = 0.02) and executive function (β = -0.05, p = 0.04). The association with executive function was no longer significant after inclusion of folate in the regression model (β = -0.032, p = 0.22). Change in working memory and attention were not associated with plasma homocysteine, folate or B12. High homocysteine was associated with greater decline with a Cohen's d effect size of approximately 0.7 compared to low homocysteine. Conclusions: In a population of older hypertensive patients, higher plasma homocysteine was associated with cognitive decline"
  • Midlife and Late-Life Blood Pressure and Dementia in Japanese Elderly: The Hisayama Study - Hypertension. 2011 May 9 - "We followed up a total of 668 community-dwelling Japanese individuals without dementia, aged 65 to 79 years, for 17 years and examined the associations of late-life and midlife hypertension with the risk of vascular dementia and Alzheimer disease using the Cox proportional hazards model ... The age- and sex-adjusted incidence of vascular dementia significantly increased with elevated late-life blood pressure levels (normal: 2.3, prehypertension: 8.4, stage 1 hypertension: 12.6, and stage 2 hypertension: 18.9 per 1000 person-years; P(trend)<0.001), whereas no such association was observed for Alzheimer disease (P(trend)=0.88). After adjusting for potential confounding factors, subjects with prehypertension and stage 1 or stage 2 hypertension had 3.0-fold, 4.5-fold, and 5.6-fold greater risk of vascular dementia, respectively, compared with subjects with normal blood pressure. Likewise, there was a positive association of midlife blood pressure levels with the risk of vascular dementia but not with the risk of Alzheimer disease. Compared with those without hypertension in both midlife and late life, subjects with midlife hypertension had an ≈5-fold greater risk of vascular dementia, regardless of late-life blood pressure levels. Our findings suggest that midlife hypertension and late-life hypertension are significant risk factors for the late-life onset of vascular dementia but not for that of Alzheimer disease in a general Japanese population. Midlife hypertension is especially strongly associated with a greater risk of vascular dementia, regardless of late-life blood pressure levels"
  • Packing on the pounds in middle age linked to dementia - Science Daily, 5/2/11 - "people who were overweight or obese at midlife had an 80 percent higher risk of developing dementia, Alzheimer's disease or vascular dementia in late life compared to people with normal BMI"
  • Treating high blood pressure, cholesterol, diabetes may lower risk of Alzheimer's disease - Science Daily, 4/13/11 - "After five years, 298 people developed Alzheimer's disease. The others still had mild cognitive impairment. People with risk factors such as high blood pressure, diabetes, cerebrovascular disease and high cholesterol were two times more likely to develop Alzheimer's disease than those without vascular risk factors. A total of 52 percent of those with risk factors developed Alzheimer's disease, compared to 36 percent of those with no risk factors ... Of those with vascular risk factors, people who were receiving full treatment were 39 percent less likely to develop Alzheimer's disease than those receiving no treatment. Those receiving some treatments were 26 percent less likely to develop the disease compared to people who did not receive any treatment ... Although this was not a controlled trial, patients who were treated for their high blood pressure, high cholesterol, heart disease and diabetes had less progression of their memory or thinking impairment and were less likely to develop dementia"
  • Study links inflammation in brain to some memory decline - Science Daily, 4/13/11 - "adults with measureable levels of C reactive protein recalled fewer words and had smaller medial temporal lobes ... Scientists don't know if the inflammation indicated by the C reactive protein is the cause of the memory loss, if it reflects a response to some other disease process or if the two factors are unrelated. But if inflammation causes the cognitive decline, relatively simple treatments could help"
  • Indications of Alzheimer's disease may be evident decades before first signs of cognitive impairment - Science Daily, 3/28/11
  • Hearing loss associated with development of dementia - Science Daily, 2/14/11 - "follow-up of 11.9 years ... for every 10 decibels of hearing loss, the extra risk increased by 20 percent ... "A number of mechanisms may be theoretically implicated in the observed association between hearing loss and incident dementia," the authors write. Dementia may be overdiagnosed in individuals with hearing loss, or those with cognitive impairment may be overdiagnosed with hearing loss. The two conditions may share an underlying neuropathologic process. "Finally, hearing loss may be causually related to dementia, possibly through exhaustion of cognitive reserve, social isolation, environmental deafferentation [elimination of sensory nerve fibers] or a combination of these pathways.""
  • Insulin metabolism and the risk of Alzheimer disease: The Rotterdam Study - Neurology. 2010 Nov 30;75(22):1982-7 - "Diabetes mellitus has been associated with an increased risk of Alzheimer disease (AD), but how it exerts its effect remains controversial ... Levels of insulin and insulin resistance were associated with a higher risk of AD within 3 years of baseline. After 3 years, the risk was no longer increased. Glucose was not associated with a higher risk of AD"
  • Bilingualism delays onset of Alzheimer's symptoms - Science Daily, 11/8/10
  • New findings pull back curtain on relationship between iron and Alzheimer's disease - Science Daily, 10/6/10 - "there is a very close link between elevated levels of iron in the brain and the enhanced production of the amyloid precursor protein, which in Alzheimer's disease breaks down into a peptide that makes up the destructive plaques ... it had been known that an abundance of iron in brain cells somehow results in an abundance of amyloid precursor protein, or APP, and its destructive peptide offspring"
  • Low testosterone linked to Alzheimer's disease - Science Daily, 10/5/10 - "Low levels of the male sex hormone, testosterone, in older men is associated with the onset of Alzheimer's disease"
  • Mild memory loss is not a part of normal aging, new research finds - Science Daily, 9/15/10 - "Simply getting older is not the cause of mild memory lapses often called senior moments ... even the very early mild changes in memory that are much more common in old age than dementia are caused by the same brain lesions associated with Alzheimer's disease and other dementias ... The very early mild cognitive changes once thought to be normal aging are really the first signs of progressive dementia"
  • Insulin resistance, type 2 diabetes linked to plaques associated with Alzheimer's disease - Science Daily, 8/25/10 - "People with insulin resistance and type 2 diabetes appear to be at an increased risk of developing plaques in the brain that are associated with Alzheimer's disease ... people who had abnormal results on three tests of blood sugar control had an increased risk of developing plaques. Plaques were found in 72 percent of people with insulin resistance and 62 percent of people with no indication of insulin resistance" -  [Abstract]
  • Gum inflammation linked to Alzheimer's disease - Science Daily, 8/3/10 - "cognitively normal subjects with periodontal inflammation are at an increased risk of lower cognitive function compared to cognitively normal subjects with little or no periodontal inflammation ... subjects with Alzheimer's disease had a significantly higher level of antibodies and inflammatory molecules associated with periodontal disease in their plasma compared to healthy people ... the Digit Symbol Test, or DST, a part of the standard measurement of adult IQ ... periodontal inflammation at age 70 was strongly associated with lower DST scores at age 70. Subjects with periodontal inflammation were nine times more likely to test in the lower range of the DST compared to subjects with little or no periodontal inflammation" - Note:  See my dental page.  Gum disease has been linked to several other heath conditions including diabetes and heart disease.  Over the years I've tried several methods for gum disease including floss, Periostat and Arestin and here is the only method that worked:
  • Abdominal fat at middle age associated with greater risk of dementia: Obesity linked to lower total brain volume - Science Daily, 5/20/10 - "excess abdominal fat places otherwise healthy, middle-aged people at risk for dementia later in life ... 24.3 million people have some form of dementia, with 4.6 million new cases annually"
  • Lowering Systolic BP in Midlife Reduces the Risk of Late-Life Dementia - Medscape, 5/17/10 - "17.7% of cases could be attributed to prehypertension (systolic BP 120 to <140 mm Hg), regardless of treatment status, or 11 excess cases per 1000"
  • Homocysteine is associated with hippocampal and white matter atrophy in older subjects with mild hypertension - Int Psychogeriatr. 2010 Apr 7:1-8 - "In older hypertensives, plasma homocysteine levels are associated with increased rates of progressive white matter and hippocampal atrophy"
  • Severe Hypoglycemia Raises Dementia Risk in Type 2 Elderly - Clinical Psychiatry News, 3/10 - "compared with patients who had no severe hypoglycemic episodes were 1.7 for those with at least one episode, 2.2 for two or more, and 2.6 for three or more episodes. Further adjustment for diabetes-related comorbidity, HbA1c level, diabetes treatment, and years of insulin use modestly attenuated the effect but it remained “statistically significant and clinically relevant” with hazard ratios of 1.3, 1.8, and 1.9, respectively"
  • Diabetes Accelerates Conversion of Mild Cognitive Impairment to Dementia - Medscape, 1/11/10 - "Our study demonstrates that individuals with mild cognitive impairment and diabetes are at increased risk of developing dementia"
  • Hypertension Drugs May Cut Alzheimer's Risk - WebMD, 1/12/10 - "The patients taking an angiotensin receptor blocker had a 19% lower risk of developing dementia compared to those taking lisinopril and a 24% lower risk compared to use of other blood pressure/heart medications. People taking both an ACE inhibitor and an angiotensin receptor blocker, which both target the angiotensin system, had a 46% lower risk of dementia compared with those taking other medications"
  • Dementia linked to high blood pressure years earlier - Science Daily, 1/12/10 - "Women who, at the start of the study, were hypertensive, meaning a blood pressure of 140/90 or higher, had significantly more white matter lesions on their MRI scans eight years later than participants with normal blood pressure. Lesions were more common in the frontal lobe, the brain's emotional control center and home to personality, than in the occipital, parietal or temporal lobes"
  • Hypertension Linked to White-Matter Disease Progression: Study - Medscape, 1/7/10 - "Long-standing hypertension is strongly associated with progression of white-matter hyperintensity (WMH), which is known to be associated with new or worsening cognitive impairment and dementia"
  • Cell phone exposure may protect against and reverse Alzheimer's disease - Science Daily, 1/6/10
  • Alzheimer's Disease: Amyloid Precursor Protein -- Good, Bad Or Both? - Science Daily, 12/29/09
  • Delaying the aging process protects against Alzheimer's disease - Science Daily, 12/10/09 - "Aging is the single greatest risk factor for Alzheimer's disease. In their latest study, researchers at the Salk Institute for Biological Studies found that simply slowing the aging process in mice prone to develop Alzheimer's disease prevented their brains from turning into a neuronal wasteland ... he slowed the aging process in a mouse model for Alzheimer's by lowering the activity of the IGF-1 signaling pathway ... mice with reduced IGF-1 signaling live up to 35 percent longer than normal mice ... Although long-lived mice didn't show any of the cognitive or behavioral impairments typical of Alzheimer's disease till very late in life, their brains were riddled with highly compacted plaques"
  • Alzheimer's: Destructive amyloid-beta protein may also be essential for normal brain function - Science Daily, 11/23/09 - "Alzheimer's disease is thought to be caused by the build-up of a brain peptide called amyloid-beta. That's why eliminating the protein has been the focus of almost all drug research pursuing a cure for the devastating neurodegenerative condition ... amyloid-beta is also necessary to maintain proper brain functioning"
  • NSAIDs Prevent Early Sign Of Alzheimer Disease In Mice - Science Daily, 11/9/09
  • Statins Show Dramatic Drug And Cell Dependent Effects In The Brain - Science Daily, 10/28/09 - "Besides their tremendous value in treating high cholesterol and lowering the risk of heart disease, statins have also been reported to potentially lower the risks of other diseases, such as dementia ... statin drugs can have profoundly different effects on brain cells -both beneficial and detrimental ... simvastatin reduced the expression of the cholesterol transporter ABCA1 by approximately 80% in astrocytes, while pravastatin lowered expression by only around 50%. Another interesting difference was that while both statins decreased expression of the Tau protein -associated with Alzheimer's disease -- in astrocytes, they increased Tau expression in neurons; pravastatin also increased the expression of another Alzheimer's hallmark, amyloid precursor protein (APP)"
  • Risk Of Abnormally Slow Heart Rate Twice As High In Those Taking Drugs To Slow Alzheimer's - Science Daily, 10/1/09
  • Antihypertensive Therapy Slows Cognitive Decline in Alzheimer Disease - Medscape, 9/29/09 - "patients using antihypertensive treatments had significantly higher MMSE scores at 1, 2, and 3 years, compared with patients not taking antihypertensive treatments"
  • High Cholesterol Linked to Alzheimer's - WebMD, 8/4/09 - "Adults with even moderately elevated cholesterol in their early to mid-40s appear to have an increased risk for Alzheimer's disease and related dementias decades later ... Total cholesterol in the high range at study entry was associated with a 66% increase in Alzheimer's risk, while having borderline high cholesterol raised the risk for vascular dementia by 52% ... total cholesterol of 240 or higher is considered high, and a cholesterol of 200 to 239 is considered borderline high" - Maybe that's why most studies on statins show that statins reduce the odds of having Alzheimer's. - Ben
  • Cognitive Deficit in Amyloid-{beta}-Injected Mice Was Improved by Pretreatment With a Low Dose of Telmisartan Partly Because of Peroxisome Proliferator-Activated Receptor-{gamma} Activation - Hypertension. 2009 Jul 27 - "Taken together, our findings suggest that even a low dose of telmisartan had a preventive effect on cognitive decline in an Alzheimer disease mouse model, partly because of PPAR-gamma activation"
  • Promising New Treatment For Alzheimer’s Disease - Science Daily, 7/20/09
  • Statin Drugs May Cut Dementia Risk - WebMD, 7/14/09 - "people who took statin drugs were 58% less likely to develop dementia than those who did not ... So what is going on? A risk factor for dementia is high insulin; one theory is that statins may lower the high insulin levels in the brain. Statins have also been shown to reduce levels of C-reactive protein (CRP), a marker of inflammation that has been linked to the pathology that can lead to dementia"
  • Inflammation May Trigger Alzheimer's Disease - Science Daily, 7/8/09 - "Inflammation, which is part of the body's natural immune response, occurs when the body activates white blood cells and produces chemicals to fight infection and invading foreign substances ... We induced inflammation in mice and found that it turned off the LRP pump that lets amyloid beta protein exit the brain into the bloodstream. It also revved up an entrance pump that transports amyloid beta into the brain. Both of these actions would increase the amount of amyloid beta protein in the brain"
  • Dementia Drugs May Put Some Patients At Risk - Science Daily, 5/27/09
  • Delirium Rapidly Accelerates Memory Decline In Alzheimer's Patients - Science Daily, 5/4/09
  • Memory Grows Less Efficient Very Early In Alzheimer's Disease - Science Daily, 5/4/09
  • Very Low Blood Sugar Linked to Dementia - WebMD, 4/17/09 - "Compared to patients with no history of low blood sugar requiring treatment, patients with a single episode of hospital-treated hypoglycemia were found to have a 26% increase in dementia risk ... Patients treated three or more times for hypoglycemia had nearly double the dementia risk of patients who had never been treated"
  • Alzheimer's Disease Linked To Mitochondrial Damage - Science Daily, 4/2/09
  • Diabetes Linked To Cognitive Deterioration - Science Daily, 3/5/09 - "people with diabetes were 1.5 more likely to experience cognitive decline, and 1.6 more likely to suffer from dementia than people without diabetes ... suggests that higher-than-average levels of blood glucose (blood sugar) may have a role in this relationship ... in people with type 2 diabetes, higher levels of haemoglobin A1C (a measure of average blood glucose) are significantly associated with poorer performance on three cognitive tasks which require memory, speed and ability to manage multiple tasks at the same time. A higher A1C level was also associated with a lower score on a test of global cognitive function ... lowering A1C levels could slow the accelerated rate of cognitive decline experienced by people with diabetes"
  • Higher Education, Lower Alzheimer’s Risk - WebMD, 2/2/09
  • Drug Found That Could Reduce Risk Of Alzheimer's - Science Daily, 2/2/09 - "daily injections of hydroxyfasudil ... Both dosed groups performed significantly better than control-group rats given saline solution. On this same test, the high-dose group showed the best learning (fewest total errors) and best working memory (measured two different ways)"
  • Getting Diabetes Before 65 More Than Doubles Risk For Alzheimer's Disease - WebMD, 1/28/09 - "getting diabetes before the age of 65 corresponds to a 125 percent increased risk for Alzheimer's disease"
  • Antipsychotic Drugs Double Risk Of Death Among Alzheimer's Patients - Science Daily, 1/8/09 - "New research into the effects of antipsychotic drugs commonly prescribed to Alzheimer’s patients concludes that the medication nearly doubles risk of death over three years"
  • Old Gastrointestinal Drug Slows Aging, Researchers Say - Science Daily, 1/6/08 - "Recent animal studies have shown that clioquinol – an 80-year old drug once used to treat diarrhea and other gastrointestinal disorders – can reverse the progression of Alzheimer's, Parkinson's and Huntington's diseases ... clioquinol acts directly on a protein called CLK-1, often informally called "clock-1," and might slow down the aging process ... Because clock-1 affects longevity in invertebrates and mice, and because we're talking about three age-dependent neurodegenerative diseases, we hypothesize that clioquinol affects them by slowing down the rate of aging ... clioquinol was withdrawn from the market after being blamed for a devastating outbreak of subacute myelo-optic neuropathy (SMON) in Japan in the 1960s. However, because no rigorous scientific study was conducted at the time, and because clioquinol was used safely by millions before and after the Japanese outbreak, some researchers think its connection to SMON has yet to be proven" - I Googled clioquinol and I don't think it's available anywhere.
  • Rosiglitazone reverses memory decline and hippocampal glucocorticoid receptor down-regulation in an Alzheimer's disease mouse model - Biochem Biophys Res Commun. 2008 Dec 22 - "An early down-regulation of GR, not related to elevated plasma corticosterone levels, was found in different hippocampal subfields of the transgenic mice and this decrease was prevented by rosiglitazone. In parallel with behavioural studies, rosiglitazone also normalized GR levels in older animals. This effect may contribute to explain the attenuation of memory decline by PPARgamma activation in an AD mouse model" - Note:  That's another reason I take rosiglitazone's competitor, pioglitazone which has less chance of causing heart problems.
  • Drug Reduces Aggression, Wandering And Paranoia In Alzheimer's Patients - Science Daily, 12/9/08
  • Epilepsy Drug Shows Potential For Alzheimer’s Treatment - Science Daily, 12/8/08 - "Sodium valproate - which is marketed as the anti-seizure drug Epilim - has been shown by scientists at the University of Leeds to reactivate the body’s own defences against a small protein called amyloid beta peptide, which is the main component of the brain plaques characteristic in Alzheimer’s"
  • Does Growth Hormone Drug Slow Alzheimer's Disease? - Science Daily, 11/17/08 - "A new study shows that a drug that increases the release of growth hormone failed to slow the rate of progression of Alzheimer's disease in humans"
  • Valproic Acid May Treat Alzheimer's - WebMD, 10/27/08
  • Statins Reduce Dementia & Cognitive Impairment Risk - Physician's Weekly Article, 10/13/08 - "Patients who had used statins were about half as likely as those who did not use the drugs to develop dementia or CIND"
  • Possibilities -- But No Proof -- To Prevent Alzheimer’s - Science Daily, 10/8/08 - "Physical activity and healthy living ... Diet ... Alzheimer’s vaccine ... Cardiovascular therapies ... Nonsteroidal anti-inflammatory drugs (NSAIDs) ... Estrogen ... Mental fitness"
  • Alzheimer’s: Two Drugs Better Than One - WebMD, 9/25/08
  • Benefit Of Combination Therapy For Alzheimer's Disease Confirmed - Science Daily, 9/22/08
  • Is There Hope For The Prevention Of Dementia? Summary Of Recent Findings - Science Daily, 9/2/08
  • Physical Frailty May Be Linked To Alzheimer's Disease - Science Daily, 8/12/08
  • Signs Of Alzheimer's Disease May Be Present Decades Before Diagnosis - Science Daily, 8/11/08
  • Statins May Prevent Dementia in Older Adults - Doctor's Guide, 7/29/08 - "People at high risk for dementia who took statins were half as likely to develop dementia as those who do not take statins"
  • Angiotensin Receptor Blockers Are Lower Incidence, Progression Of Alzheimer's Disease - Science Daily, 7/27/08 - "Researchers at Boston University School of Medicine (BUSM) have, for the first time, found that angiotensin receptor blockers (ARBs)—a particular class of anti-hypertensive medicines—are associated with a striking decrease in the occurrence and progression of dementia" - Note:  Telmisartan, which I've been saying should be a first line treatment, is an ARB.  See telmisartan at OffshoreRx1.com.
  • New Drug Reverses Alzheimer's Disease Within Days In Mouse Models - Science Daily, 7/9/08
  • To Avoid Dementia, Watch Your Weight - WebMD, 5/8/08 - "obese people have an 80% increased risk for Alzheimer's disease compared to those with normal weight"
  • Using Anti-cholinergic Drugs May Increase Cognitive Decline In Older People - Science Daily, 4/17/08 - "Anticholinergic drugs, such as medicines for stomach cramps, ulcers, motion sickness, and urinary incontinence, may cause older people to experience greater decline in their thinking skills than people not taking the drugs"
  • High Cholesterol In Your 40s Increases Risk Of Alzheimer's Disease - Science Daily, 4/16/08 - "people with total cholesterol levels between 249 and 500 milligrams were one-and-a-half times more likely to develop Alzheimer's disease than those people with cholesterol levels of less than 198 milligrams. People with total cholesterol levels of 221 to 248 milligrams were more than one-and-a-quarter times more likely to develop Alzheimer's disease"
  • Alzheimer's Starts Earlier For Heavy Drinkers, Smokers - Science Daily, 4/16/08 - "the combination of heavy drinking and heavy smoking reduced the age of onset of Alzheimer's disease by six to seven years, making these two factors among the most important preventable risk factors for Alzheimer's disease"
  • Insulin Trouble Tied to Alzheimer's - WebMD, 4/9/08 - "the men took fasting glucose tests to show how well their body used insulin, a hormone that controls blood sugar ... Men who had a weaker insulin response to that test were 31% more likely to be diagnosed with Alzheimer's disease later in life" - See my Insulin and Aging page.
  • Big Bellies Linked to Alzheimer's Disease - washingtonpost.com, 3/26/08 - "People who have big bellies in their 40s are much more likely to get Alzheimer's disease and other forms of dementia in their 70s" - [Science Daily]
  • One In Six Women, One In Ten Men At Risk For Alzheimer's Disease In Their Lifetime - Science Daily, 3/18/08
  • Childhood Lead Exposure Linked To Alzheimer's Disease, Study Suggests - Science Daily, 2/17/08
  • More Brain Research Suggests 'Use It Or Lose It' - Science Daily, 2/7/08 - "It appears that if a cell is not appropriately stimulated by other cells, it self-destructs ... This self-destruct process is also known to be an important factor in stroke, Alzheimer's and motor neuron diseases, leading to the loss of essential nerve cells from the adult brain"
  • Telomere length in white blood cells, buccal cells and brain tissue and its variation with ageing and Alzheimer's disease - Mech Ageing Dev. 2008 Jan 31 - "We observed a significantly lower telomere length in white blood cells (P<0.0001) and buccal cells (P<0.01) in Alzheimer's patients relative to healthy age-matched controls (31.4% and 32.3%, respectively)"
  • Rosiglitazone increases dendritic spine density and rescues spine loss caused by apolipoprotein E4 in primary cortical neurons - Proc Natl Acad Sci U S A. 2008 Jan 22 - "rosiglitazone significantly increased dendritic spine density in a dose-dependent manner in cultured primary cortical rat neurons. This effect was abolished by the PPAR-gamma-specific antagonist, GW9662, suggesting that rosiglitazone exerts this effect by activating the PPAR-gamma pathway. Furthermore, the C-terminal-truncated fragment of apoE4 significantly decreased dendritic spine density. Rosiglitazone rescued this detrimental effect. Thus, rosiglitazone might improve cognition in AD patients by increasing dendritic spine density"
  • People With Dementia Survive On Average Four And A Half Years After Diagnosis - Science Daily, 1/11/08
  • Reversal Of Alzheimer's Symptoms Within Minutes In Human Study - Science Daily, 1/9/08
  • Lead Link to Alzheimer's Disease? - WebMD, 1/2/08
  • High Blood Pressure Associated With Risk For Mild Cognitive Impairment - Science Daily, 12/12/07 - "Hypertension (high blood pressure) was associated with an increased risk of all types of mild cognitive impairment that was mostly driven by an increased risk of non-amnestic mild cognitive impairment ... Preventing and treating hypertension may have an important impact in lowering the risk of cognitive impairment"
  • Lipids In The Brain An Important Factor For Alzheimer's Disease? - WebMD, 12/10/07
  • High Blood Pressure May Heighten Effects Of Alzheimer's Disease - Science Daily, 11/28/07 - "Having hypertension, or high blood pressure, reduces blood flow in the brains of adults with Alzheimer's disease"
  • Copper Damages Protein That Defends Against Alzheimer's - Science Daily, 11/7/07 - "Copper can damage a molecule that escorts out of the brain a substance called amyloid beta that builds up in toxic quantities in the brains of people with Alzheimer's disease ... having appropriate levels of copper in our body is crucial for our health. Copper helps keep our bones our strong and our skin toned, and it helps our nerves fire crisply and our cells to generate the energy we need to live. It helps keep our blood healthy so we can get the oxygen we need to all our organs. And it plays a role in keeping our immune system strong"
  • Maternal Link to Alzheimer's Disease Found - Doctor's Guide, 11/6/07 - "People who have a mother with Alzheimer's disease appear to be at higher risk for getting the disease than those individuals whose fathers are afflicted ... People with an affected parent have a 4- to 10-fold higher risk compared to individuals with no family history. It isn't known why people with a family history are more susceptible to the disease"
  • High Blood Pressure Or Irregular Heartbeat Linked To Alzheimer's Disease Progression - Science Daily, 11/5/07 - "10 with high blood pressure (systolic pressure over 160) at the time of AD diagnosis showed a rate of memory loss roughly 100 percent faster than those with normal blood pressure ... 10 with atrial fibrillation at the time of the diagnosis showed a rate of memory decline that was 75 percent faster than those with normal heartbeats"
  • Pet Scan Helps Distinguish Alzheimer's from Other Dementia - Doctor's Guide, 11/2/07
  • Drugs For Hypertension May Help Prevent And Treat Alzheimer's Disease - Science Daily, 10/26/07 - "mice genetically determined to develop Alzheimer's disease beta-amyloid production and subsequent cognitive deterioration, significantly benefit from the treatment with the anti-hypertensive agent Valsartan, found to pharmacologically prevent beta-amyloid production in the brain even when delivered to Alzheimer's disease mice at doses 3-4 fold lower than the minimal equivalent dose prescribed for the treatment of hypertension in humans. Other anti-hypertension drugs with beneficial results included Propranolol HCI, Carvedilol, Losartan, Nicardipine HCI, Amiloride HCI and Hydralazine HCI" - Note:  I'm big on Micardis (telmisartan).  Valsartan and losartan (generic names so they shouldn't have been capitalized) are also ARBs.  I'm wondering if telmisartan was in the study.
  • Alzheimer's Disease: Injectable Antibody May Attack Source Of Problem - Science Daily, 10/8/07
  • Cholesterol Metabolism Links Early- And Late-onset Alzheimer's Disease - Science Daily, 10/4/07
  • Low Education Level Linked To Alzheimer's, Study Shows - Science Daily, 10/2/07
  • Does Conscience Curb Alzheimer's? - WebMD, 10/1/07
  • Alzheimer's Disease Could Be A Third Form Of Diabetes - Science Daily, 9/26/07
  • Statins May Help Alzheimer's Patients - washingtonpost.com, 9/11/07 - "Those patients who had taken statins before they died showed significantly lower levels of tangles in their brains ... Our data says these drugs appear to be doing something in the human brain ... Whether this will translate into behavioral changes, we can't say ... subjects had taken statins for only five years or less. It may be that longer use of statins would offer more protection" - See atorvastatin at OffshoreRx1.com.
  • New Alzheimer's findings: High stress and genetic risk factor lead to increased memory decline - Doctor's Guide, 8/27/07 - "High stress levels may contribute to memory loss among people at risk for developing Alzheimer's disease"
  • Statins May Cut Alzheimer's Disease - WebMD, 8/27/07 - "participants who had taken statins were 80% less likely to have brain changes typical of Alzheimer's disease than those who hadn't taken statins"
  • Weight Loss: Early Sign of Dementia? - WebMD, 8/20/07
  • Alzheimer's Disease Linked To Glaucoma - Science Daily, 8/6/07
  • Should Antipsychotic Drugs Be Taken For Dementia? - Science Daily, 7/27/07
  • Zocor vs. Alzheimer's and Parkinson's - WebMD, 7/18/07 - "In patients over age 64, those who took Zocor were 54% less likely to get Alzheimer's disease and 49% less likely to get Parkinson's disease than were matched patients not taking statin drugs ... Those who took Lipitor were 9% less likely to get Alzheimer's disease" - See simvastatin at OffshoreRx1.com.
  • Blood Inflammation Plays Role in Alzheimer's Disease - Doctor's Guide, 5/29/07 - "The participants' blood was tested for levels of cytokines, which are protein messengers that trigger inflammation. Those with the highest amount of cytokines in their blood were more than twice as likely to develop Alzheimer's disease as those with the lowest amount of cytokines"
  • Some Hypertension Drugs May Help Reduce Dementia Risk - Science Daily, 5/5/07 - "Centrally acting drugs include captropril (Capoten®), fosinopril (Monopril®), lisinopril (Prinivil® or Zestri®), perindopril (Aceon®), ramipril (Altace®) and trandolapril (Mavik®) ... The study found a link between taking centrally active ACE inhibitors and lower rates of mental decline as measured by the Modified Mini-Mental State Exam, a test that evaluates memory, language, abstract reasoning and other cognitive functions"
  • Estrogen Use Before 65 Linked To Reduced Risk Of Alzheimer's Disease - Science Daily, 5/2/07 - "women who used any form of estrogen hormone therapy before the age of 65 were nearly 50 percent less likely to develop Alzheimer's disease or dementia"
  • Testosterone May Slow Alzheimer's - WebMD, 12/19/06 - "The mice that couldn't make testosterone developed more brain plaque, a hallmark of Alzheimer's disease. Those mice also had more trouble in a maze test"
  • High Cholesterol Linked to Increased AD Risk - Medscape, 11/6/06 - "With a 3- to 4-fold increase in the number of memory errors, normal mice on the high-fat diet had significantly poorer memory performance than controls ... This finding indicates it may not be increased cholesterol levels per se that adversely affect memory but the associated inflammation"
  • Antipsychotic Drugs for Alzheimer's? - WebMD, 10/11/06
  • Weight Loss Tied to Early Alzheimer's - WebMD, 9/11/06
  • Antidiabetic Agents Show Some Promise in Treating Alzheimer's Disease - Medscape, 7/27/06 - "The findings in these studies clearly support the growing paradigm shift regarding the pathogenesis of AD, ie, that AD is caused by insulin resistance and insulin deficiency in the brain"
  • Benefits of Cholinesterase Inhibitors Extend for Almost 3 Years - Doctor's Guide, 7/23/06
  • Prediabetes May Raise Risk for Alzheimer's - Intelihealth, 7/17/06 - "people who had prediabetes at the beginning of the study had a 70% increased risk of developing dementia, including Alzheimer's ... doctors tend to ignore the slightly high sugar levels until the levels reach the stage of full-blown diabetes"
  • Addition of Leuprolide Acetate to Standard Therapy Preserves Functioning in Women with Alzheimer's Disease - Doctor's Guide, 7/17/06
  • Diabetes Drug Shows Promise in Treating Alzheimer's - Doctor's Guide, 7/17/06 - "Treatment of high blood sugar may have a scientific connection to memory loss that could, one day, benefit millions of people with Alzheimer's Disease ... The drug, called pioglitazone HCl"
  • Antihypertensive Agents May Be Linked to Decreased Risk for Alzheimer Disease - Medscape, 5/9/06 - "The use of any antihypertensive medications significantly reduced the risk of developing AD (adjusted HR, 0.64). This result did not vary by sex, APOE status, subjects' blood pressure values, or the duration of antihypertensive use ... potassium-sparing diuretics had the most significant affect on the risk of AD ... this effect was almost entirely due to the effects of potassium-sparing agents"
  • Alzheimer's patients put diabetes pill [Avandia] to the test - MSNBC, 5/1/06 - "The new theory: The metabolism of neurons’ internal power factors, called mitochondria, go awry so that those cells don’t use enough sugar. That eventually leads to impaired brain cell function, including the buildup of that gunky beta-amyloid. It also means that neurons in youth and middle age don’t sprout enough communication connections, providing less “cognitive reserve” once their neurons start dying off" - See my Avandia page.
  • Leuprolide Acetate Stabilises Cognitive Decline in Women With Alzheimer's Disease - Doctor's Guide, 4/24/06
  • Is Long-Term Treatment With Cholinesterase Inhibitors Justified? - Doctor's Guide, 4/21/06
  • Sustained Blood Pressure Treatment Lowers Dementia Risk In Elderly - Science Daily, 4/10/06 - "each year of treatment reduced the risk of developing dementia during the follow-up period by about 3 percent. Compared with men who were never treated for hypertension, the risk of developing dementia during the follow-up period was: ... 60 percent lower in those treated more than 12 years -- similar to the risk in a control group of 446 men with normal blood pressure"
  • Insulin Sensitizers Cut Cognitive Decline in AD - Clinical Psychiatry News, 4/06 - "There is a critical relationship between insulin resistance and key aspects of brain function ... patients taking rosiglitazone performed significantly better than those taking placebo on a delayed memory task (the Buschke Selective Reminding Test)" - See OffshoreRx1.com.
  • Use of Potassium-Sparing Diuretics Cuts AD Risks - Clinical Psychiatry News, 4/06 - "The risk of developing AD was significantly smaller in those who took antihypertensive medications than in those who did not (adjusted hazard ratio [aHR] 0.64). When the results were broken down by drug class, diuretics showed the greatest protective effect against AD"
  • Anxiety in Alzheimer's Disease Patients is Not Being Recognized - Doctor's Guide, 3/29/06
  • Hypertension Drugs May Cut Alzheimer's - WebMD, 3/13/06 - "People taking drugs for high blood pressure -- especially certain diuretics -- were less likely to have developed Alzheimer's"


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