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More support for vitamin D’s colorectal protection - Nutra USA, 8/12/10 -
"In people using NSAIDs, the potential risk
reduction of higher vitamin D levels was increased to 66 per cent" - [Abstract]
vitamin D at Amazon.com.
Blood 25-Hydroxyvitamin D3 Concentrations and Incident Sporadic Colorectal
Adenoma Risk: A Pooled Case-Control Study - Am J Epidemiol. 2010 Jul 22
"In the pooled analysis, higher circulating 25(OH)D(3)
concentrations were statistically significantly associated with decreased
colorectal adenoma risk (highest vs. lowest quartile odds ratio = 0.59, 95%
confidence interval: 0.41, 0.84). The observed inverse association was
stronger among participants who used nonsteroidal antiinflammatory drugs
regularly (highest vs. lowest quartile odds ratio = 0.33, 95% confidence
interval: 0.19, 0.56). Inverse associations between 25(OH)D(3) and
colorectal adenoma did not differ substantially by other risk factors or by
adenoma characteristics. These findings support the hypothesis that greater
vitamin D exposure may reduce the risk of colorectal adenoma and suggest
that it may do so more strongly in combination with antiinflammatory agents"
vitamin D at Amazon.com.
Cod liver oil (n-3
fatty acids) as an non-steroidal anti-inflammatory drug sparing agent in
rheumatoid arthritis - Rheumatology (Oxford). 2008 Mar 24 -
"Out of 49 patients 19 (39%) in the cod liver oil group and out of 48
patients 5 (10%) in the placebo group were able to reduce their daily NSAID
requirement by >30% ... This study suggests that cod liver oil supplements
containing n-3 fatty acids can be used as NSAID-sparing agents in RA
patients" - See
cod liver oil at Amazon.com
Mega Twin EPA at Amazon.com.
Before A CT Scan Or Angiogram, Many People Should Take Inexpensive Drug To
Protect Kidneys - Science Daily, 2/18/08 - "The
inexpensive drug, called N-acetylcysteine, can prevent serious kidney damage
that can be caused by the iodine-containing "dyes" that doctors use to
enhance the quality of such scans ... N-acetylcysteine is already widely
used to clear mucus in cystic fibrosis patients, and to treat overdoses of
acetaminophen" - See
n-acetyl cysteine at Amazon.com.
Short-Course N-Acetylcysteine Effective for Acetaminophen Overdose -
Medscape, 10/4/07 - "A shortened course of as few as
six oral doses of N-acetylcysteine appears to be an effective treatment for
certain patients with acute acetaminophen poisoning" - See
n-acetyl cysteine at Amazon.com.
A Safer Alternative to NSAIDs? - Physician's Weekly, 7/3/06 -
"omega-3 essential fatty acid (EFA) may be as
effective as nonsteroidal anti-inflammatory drugs (NSAIDs) in relieving neck
and lower back pain without the risk of harmful complications"
Patients Seek Natural Alternatives to NSAIDs - Clinical Psychiatry News,
7/05 - "In a double-blind, placebo-controlled trial
of 21 patients who took 240 mg of salicin over a 2-week period, Western
Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain scores
were reduced 40%, compared with a 16% reduction among those on placebo. At 2
weeks, the analgesic effect from willow bark was assessed to be about 40% of
that from high-dose NSAIDs" - See
willow bark products.
Glucosamine Ups Ibuprofen's Pain Relief - WebMD, 1/9/04 -
"While the NSAID administered alone had
glucosamine administered alone produced no pain-relieving effect ... But
when glucosamine was combined with an NSAID, pain relief was more
pronounced" - See ibuprofen at Amazon.com
Drug therapy of activated arthrosis. On the effectiveness of an enzyme
mixture versus diclofenac - Wien Med Wochenschr. 1996;146(3):55-8 (I
thought this study was interesting because it showed that Wobenzym® was as
effective as diclofenac. In
another study, diclofenac was show to be as effective as Vioxx. That
said, it would make sense that Wobenzym should be as effective as Vioxx.)
This popular painkiller also kills kindness - Washington Post, 5/12/16 -
"Acetaminophen, the most common drug ingredient in the
United States, can reduce a person's capacity to empathize with another person's
pain, whether that pain is physical or emotional"
Acetaminophen in pregnancy may lower testosterone in unborn boys - Science
Daily, 5/20/15 - "Testosterone, produced in the
testicles, is crucial for life-long male health. Reduced exposure to the hormone
in the womb has been linked to an increased risk of infertility, testicular
cancer and undescended testicles ... Scientists gave the mice a typical daily
dose of paracetamol -- over a period of either 24 hours or seven days ... After
seven days of exposure, however, the amount of testosterone was reduced by 45
Non-steroidal anti-inflammatory drugs and the risk of head and neck cancer: A
case-control analysis - Int J Cancer. 2015 May 13 -
"Aspirin or NSAID use overall did not significantly change the HNC risk.
However, patients with six or more prescriptions for ibuprofen were at a
statistically significantly reduced risk for HNC (adjusted OR 0.59, 95% CI
Study: Acetaminophen reduces not only pain but pleasure - CNN.com, 4/15/15 -
"acetaminophen, the main ingredient in Tylenol, most
forms of Midol and more than 600 other medicines, reduces not only pain but
pleasure, as well"
of Non-steroidal Anti-inflammatory Drugs with Colorectal Cancer by Subgroups in
the VITamins And Lifestyle (VITAL) Study - Cancer Epidemiol Biomarkers Prev.
2015 Jan 22 - "In stratified analysis, high use of any
type of NSAIDs (4+days/week for 4+ years) was statistically significantly
associated with a lower risk of CRC across all subgroups stratified by sex, BMI,
physical activity, smoking, alcohol intake, screening and dietary factors. There
was a suggestion of stronger associations among men, obese individuals, and
heavier drinkers; however, none of these tests for interaction reached
statistical significance. The associations were almost identical for subjects
with higher overall CRC risk scores (HR: 0.62; 95% CI: 0.49-0.79) and those with
lower risk scores (HR: 0.61; 95% CI: 0.42-0.88)"
Ibuprofen Extends Life In Lab Species, Study Finds (Humans, Too?) - NBC
News.com, 12/18/14 - "The ibuprofen administered to test
subjects was comparable to recommended amounts for humans ... The treatments
gave the organisms roughly 15 percent more life — equal to about 12 human years"
ibuprofen at Amazon.com.
Help Ease Depression - Medscape, 10/21/14 - "Results
of a meta-analysis show that the adjunctive use of NSAIDs was associated with
improved antidepressant treatment response without an increased risk for adverse
effects. In particular, add-on treatment with celecoxib (Celebrex, GD Searle
LLC) improved antidepressant effects, remission, and response"
Ibuprofen no good in treating colds or sore throats - Science Daily, 11/4/13
- "compared with paracetamol, ibuprofen or a combination
of both ibuprofen and paracetamol provide no advantage for patients overall with
respiratory tract infections (otherwise known as colds or sore throats) ...
steam inhalation, another common treatment method, has no clear benefit and
around 2 per cent of people get mild scalding but not bad enough to see a doctor
... The research also showed that patients were more likely to come back within
a month with worsening symptoms or new symptoms if they were prescribed with
ibuprofen or ibuprofen with paracetamol"
prevalence of NSAID prescription in those at risk of heart attack/death in
primary care - Science Daily, 6/14/13 - "These data
demonstrate an immediate increase in the risk of death and MI, challenging the
safety of even short term use"
use linked to reduced hepatocellular carcinoma risk and mortality due to chronic
liver disease - Science Daily, 11/28/12 -
"Hepatocellular carcinoma (HCC), the most common type of primary liver cancer,
occurs mainly among patients with CLD ... performed an observational study of
300,504 men and women aged 50 to 71 years enrolled in the National Institutes of
Health-AARP Diet and Health Study who reported their aspirin and nonaspirin
NSAID use and were followed-up for 10-12 years ... Study participants who used
aspirin had a 41% reduced risk of HCC and a 45% reduced risk of death from CLD,
whereas those who used non-aspirin NSAIDs experienced a 26% reduced risk of CLD
mortality but no reduced risk of HCC"
pain-relieving medicines linked to hearing loss in women - Science Daily,
9/12/12 - "women who took ibuprofen or acetaminophen two
or more days per week had an increased risk of hearing loss. The more often a
woman took either of these medications, the higher her risk for hearing loss.
Also, the link between these medicines and hearing loss tended to be greater in
women younger than 50 years old, especially for those who took ibuprofen six or
more days per week ... Compared with women who used acetaminophen less than once
per week, women who used acetaminophen 2 to 3 days per week had an 11 percent
increased risk for hearing loss, while women taking the medicine 4 to 5 days per
week had a 21 percent increased risk ... Possible mechanisms might be that
NSAIDs may reduce blood flow to the cochlea -- the hearing organ -- and impair
its function ... Acetaminophen may deplete factors that protect the cochlea from
Cardiovascular Risk of NSAID Use According to Time Passed After First-Time
Myocardial Infarction: A Nationwide Cohort Study - Circulation. 2012 Sep 10
- "We identified patients aged 30 years or older
admitted with first-time MI in 1997-2009 and subsequent NSAID use by
individual-level linkage of nationwide registries of hospitalization and drug
dispensing from pharmacies in Denmark. We calculated the incidence rates of
death and a composite endpoint of coronary death or nonfatal recurrent MIs
associated with NSAID use in 1-year time intervals up to 5 years after inclusion
and analyzed risk by using multivariable adjusted time-dependent Cox
proportional-hazard models ... Relative to non-current treatment with NSAIDs,
the use of any NSAID in the years following MI was persistently associated with
an increased risk of death (hazard ratio (HR) 1.59 (95% confidence interval (CI)
1.49-1.69) after 1 year and HR 1.63 (CI 1.52-1.74) after 5 years) and coronary
death or nonfatal recurrent MI (HR 1.30 (CI 1.22-1.39) and HR 1.41 (CI
Analgesics use associated with increased risk for renal cell carcinoma -
Science Daily, 10/24/11 - "conducted a Medline
database search for case-control or cohort studies on acetaminophen, aspirin
and other nonsteroidal anti-inflammatory drugs (NSAIDs), published between
1966 and July 1, 2011...any use of acetaminophen was associated with a 33
percent increased risk for RCC, and use of other NSAIDs was linked with a 26
percent increased risk. No significantly increased risk for RCC was found
with the use of aspirin"
Anti-inflammatory drugs taken in early pregnancy more than double risk of
miscarriage, study finds - Science Daily, 9/6/11 -
"The risk of miscarriage is 2.4 times greater for women who took any type
and dosage of nonaspirin nonsteroidal anti-inflammatory drugs (NSAIDs) in
Non-Steroidal Anti-Inflammatory Drugs Linked to Increased Risk of Erectile
Dysfunction - Science Daily, 3/2/11 - "After
controlling for age, race, ethnicity, smoking status, diabetes,
hypertension, heart disease, high cholesterol and body mass index, the
researchers found that ED was 1.4 times more likely -- a modest risk --
among regular NSAID users compared to men who did not take the drugs
regularly. This association was consistent across all age groups"
Common painkillers linked to increased risk of heart problems - Science
Daily, 1/11/11 - "the absolute risk of
cardiovascular problems among people taking painkillers was low, but the
researchers did find that, relative to placebo, the drugs carried important
risks ... rofecoxib and lumiracoxib were associated with twice the risk of
heart attack, while ibuprofen was associated with more than three times the
risk of stroke. Etoricoxib and diclofenac were associated with the highest
(around four times) risk of cardiovascular death ... Naproxen appeared least
harmful in terms of cardiovascular safety among the seven analysed
preparations" - See the long version at
NSAIDs cause stem cells to self-destruct, preventing colon cancer, study
finds - Science Daily, 11/1/10
Acetaminophen Increases Blood Pressure in Patients With Coronary Artery
Disease - Circulation. 2010 Oct 18 - "Treatment
with acetaminophen resulted in a significant increase in mean systolic (from
122.4+/-11.9 to 125.3+/-12.0 mm Hg P=0.02 versus placebo) and diastolic
(from 73.2+/-6.9 to 75.4+/-7.9 mm Hg P=0.02 versus placebo) ambulatory blood
pressures. On the other hand, heart rate, endothelial function, early
endothelial progenitor cells, and platelet function did not change"
Non-Steroidal Anti-Inflammatory Drugs and Prostate Cancer Risk in the
VITamins And Lifestyle (VITAL) Cohort - Cancer Epidemiol Biomarkers
Prev. 2010 Oct 8 - "NSAID use was not associated
with prostate cancer risk in the VITAL cohort.Impact: Our findings do not
support the use of NSAIDs for chemoprevention of prostate cancer"
very low dose of regular aspirin wards off bowel cancer, study finds -
Science Daily, 9/15/10 - "After a year, taking daily
low dose aspirin was associated with a 22% reduced risk of developing bowel
cancer, and the magnitude of the reduction in risk was cumulative, rising to
30% after five years ... taking NSAIDs of any kind did not influence the
risk of death from any cause nor did it increase bowel cancer survival"
NSAID use associated with future stroke in healthy population -
theheart.org, 9/8/10 - "NSAID use was associated
with an increased risk of stroke. This increased risk ranged from about 30%
with ibuprofen and naproxen to 86% with diclofenac ... there was also a
dose-relationship found, with the increased risk of stroke reaching 90% (HR
1.90) with doses of ibuprofen over 200 mg and 100% (HR 2.0) with diclofenac
doses over 100 mg. He pointed out that the results were particularly
striking, given that this study was conducted in healthy individuals"
Slow-release NSAIDs pose greater risk of GI bleeding - Science Daily,
Regular analgesic use increases hearing loss in men, study finds -
Science Daily, 3/1/10 - "For aspirin, regular users
under 50 and those aged 50-59 years were 33% more likely to have hearing
loss than were nonregular users, but there was no association among men aged
60 years and older. For NSAIDs, regular users aged under 50 were 61% more
likely, those aged 50-59 were 32% more likely, and those aged 60 and older
were 16% more likely to develop hearing loss than nonregular users of
NSAIDs. For acetaminophen, regular users aged under 50 were 99% more likely,
regular users aged 50-59 were 38% more likely, and those aged 60 and older
were 16% more likely to have hearing loss than nonregular users of
Ibuprofen May Reduce Risk of Parkinson's - WebMD, 2/17/10 -
"the pain reliever was the only one in the popular
class of nonsteroidal anti-inflammatory drugs (NSAIDs) studied that had any
effect on risk of Parkinson's disease ... users of ibuprofen were nearly 40%
less likely to develop Parkinson's disease than those who didn't take
Could acetaminophen ease psychological pain? - Science Daily, 12/22/09 -
"These results indicate that acetaminophen use may
decrease self-reported social pain over time, by impacting emotions linked
to hurt feelings" - Note: Keep in mind that too much acetaminophen
can cause permanent liver damage. Some people take Tylenol which is
acetaminophen and top that off with several cold medications that they
didn't know also contained acetaminophen.
NSAIDs Prevent Early Sign Of Alzheimer Disease In Mice Science Daily,
11/12/09 - "If taking nonsteroidal antiinflammatory
drugs (NSAIDs) such as ibuprofen or naproxen is to protect you from
developing Alzheimer disease then you will have to start taking them at a
very early age according to research in a mouse model of the disease"
NSAIDs Prevent Early Sign Of Alzheimer Disease In Mice - Science Daily,
Increased Mortality and Cardiovascular Morbidity Associated With Use of
Nonsteroidal Anti-inflammatory Drugs in Chronic Heart Failure - Arch
Intern Med. 2009 Jan 26;169(2):141-9 - "The hazard
ratio (95% confidence interval) for death was 1.70 (1.58-1.82), 1.75
(1.63-1.88), 1.31 (1.25-1.37), 2.08 (1.95-2.21), 1.22 (1.07-1.39), and 1.28
(1.21-1.35) for rofecoxib, celecoxib, ibuprofen, diclofenac, naproxen, and
other NSAIDs, respectively. Furthermore, there was a dose-dependent increase
in risk of death and increased risk of hospitalization because of myocardial
infarction and HF. Propensity-based risk-stratified analysis and
case-crossover models yielded similar results"
NSAIDs May Cut Prostate Cancer Markers - WebMD, 9/8/08 -
"Men who reported using NSAIDs nearly every day had
PSA levels that were about 10% lower than men who reported no current NSAID
Ibuprofen May Cut Alzheimer's Risk - WebMD, 5/5/08 -
"Use of ibuprofen pain relievers like Advil and
Motrin for more than five years reduced Alzheimer's risk by 44% in a study
reported in the May issue of Neurology"
Ibuprofen, Acetaminophen Help Build Muscle in Older Resistance Trainers
- Medscape, 4/10/08 - "We used 1200 milligrams a day
for ibuprofen and 4000 milligrams per day of acetaminophen, which is the
maximum over-the-counter daily dose ... Muscle volume increased 11% in the
ibuprofen group and 13% in the acetaminophen group, compared with 9% in the
placebo. Muscle strength increased 30% in the ibuprofen group and 28% in the
acetaminophen, compared with 23% in the placebo group"
Statins, NSAIDs vs. Prostate Cancer - WebMD, 2/18/08 -
"Men with prostate cancer who take
cholesterol-lowering statin drugs or anti-inflammatory drugs live longer
than those who don't take the drugs ... men who reported ever taking statins
were 41% to 65% less likely to die during the course of the study than men
who didn't. Men who took NSAIDs were 53% to 61% less likely to die than
those who didn't"
High-dose NSAIDs May Prevent Colon Cancer - oncologystat.com. 2/5/08 -
"people who took more than 2325 mg of aspirin weekly
reduced colon cancer risk by 21%, compared to people who took less aspirin.
Men who took 7 to 14 aspirins a week had a 28% decreased risk, and those who
took more than 14 aspirins weekly had a 70% decrease in their risk of
developing the disease. The advantages were only seen after 5 years of use,
and taking less than 1½ pills weekly did not reduce the risk of developing
the disease. The effect was also seen with the use of other NSAIDs, such as
ibuprofen and naproxen"
Ibuprofen May Aid Cystic Fibrosis Lungs - WebMD, 11/30/07
Over-the-counter Pain Medications May Reduce Risk Of Parkinson's Disease
- Science Daily, 11/5/07 - "regular users of
non-aspirin NSAIDs reduced their risk of Parkinson's disease by as much as
60 percent compared to non-regular users and non-users. Women who were
regular users of aspirin reduced their risk of Parkinson's disease by 40
percent, especially among those who regularly used aspirin for more than two
Breast Cancer Risk May Decrease With Increasing Duration of NSAID Use -
Medscape, 10/1/07 - "Use of NSAIDs was associated
with a lower risk for breast cancer (odds ratio [OR], 0.76"
Why Do Common Anti-inflammatory Drugs Harm Intestines? - Science Daily,
Can Aspirin Help Keep Cancer At Bay? - Science Daily, 4/16/07 -
"those who said they regularly used aspirin had a 16
percent reduced risk of developing cancer more than a decade later, as well
as a 13 percent reduced risk of dying from cancer over this same time
period, compared to women who did not use aspirin. But there was no
statistically significant impact on cancer incidence or mortality among
women who used non-aspirin NSAIDs"
A New Way to Prevent BPH? - Physician's Weekly, 10/16/06 -
"NSAID use was inversely associated with the onset
of moderate-to-severe urinary symptoms, low maximum flow rate, and elevated
prostate-specific antigen levels"
Nonsteroidal Anti-Inflammatory Drugs Use Associated With Higher
Gastrointestinal Complications - Doctor's Guide, 9/21/06
NSAID Use May Prevent or Delay Development of Benign Prostate Hyperplasia
- Medscape, 9/6/06 - "NSAIDs reduced the incidence
rates of moderate-severe urinary symptoms (HR, 0.73), low maximum urinary
flow rate (HR, 0 .51), increased prostate volume (HR, 0.53), elevated serum
PSA level (HR, 0.52), and treatment of BPH (HR, 0.79)"
New Pain Pills:
Not Easier to Stomach? - WebMD, 12/1/05 -
"patients taking Cox-2 inhibitors had no fewer
stomach bleeds or ulcers than those taking traditional NSAIDs"
Long-Term NSAIDs May Not Be Useful for Osteoarthritis - Medscape,
11/329/05 - "Nonsteroidal anti-inflammatory drugs
(NSAIDs) offer only a small, short-term benefit that may not be clinically
significant for people with knee osteoarthritis"
Increasing Role of Acetaminophen in Acute Liver Failure in United States
- Doctor's Guide, 11/29/05 -
"Acetaminophen poisoning has become the most common
cause of acute liver failure in the United States"
NSAIDs Ups Risk of Dying After a Myocardial Infarction - Doctor's Guide,
Vitamin D, NSAIDS Provide Double Whammy Against Prostate Cancer, Stanford
Study Finds - Science Daily, 9/1/05 - "The
growth of prostate cancer cells can be halted by combining a form of vitamin
D, available only by prescription, with low doses of an over-the-counter
painkiller ... The combination reduced prostate cancer cell growth in a
laboratory dish by up to 70 percent, according to the findings"
Common Pain Drugs Up High Blood Pressure Risk - WebMD, 8/15/05 -
"Women who take a lot of acetaminophen (Tylenol)
have nearly twice the risk of high blood pressure as those who don't use the
Aspirin May Cut Prostate Cancer Risk - WebMD, 7/5/05 -
"Those who had taken aspirin regularly for a long
time were 15% less likely to be diagnosed with prostate cancer. Other
anti-inflammatory drugs were associated with an 18% lower risk of prostate
Long-Term Use of Non-Steroidal Anti-Inflammatory Drugs May Cause Severe
Intestinal Damage - Doctor's Guide, 1/3/05 -
"chronic users of non-steroidal anti-inflammatory
drugs (NSAIDs) have an increased risk of bleeding and visible damage to
their small intestine"
- What’s a consumer to do for
pain relief? - MSNBC, 12/21/04
- Aleve Linked to
Heart Attack, Stroke - WebMD, 12/21/04 -
"patients taking Aleve had 50% more heart attacks
- Aspirin May
Delay Prostate Cancer, Extend Life - WebMD, 10/4/04 -
"more than nine in 10 men who took
aspirin or another NSAID were alive 10 years later compared with fewer
than seven in 10 men who didn't take the painkillers ... evidence is
mounting that prostate cancer may develop in
areas with chronic inflammation"
- Painkillers Cut
Aspirin's Heart Benefit - WebMD, 8/25/03 -
"half took 325 mg aspirin
on alternate days; half took a placebo ... The aspirin group had 44% fewer
heart attacks than the placebo group -- 139 heart attacks in the aspirin
group; 239 in the placebo group ... Those who regularly took ibuprofen and
other common anti-inflammatory drugs did not get that protective effect"
aspirin at Amazon.com.
Study Supports Potential of Nonsteroidal Anti-inflammatory Drugs to Protect
Against Alzheimer's - Doctor's Guide, 7/22/03 -
"The pooled combined data from the cohort and
case-control studies showed a relative risk of
Alzheimer's disease was 0.72 among NSAID users ... The analysis specific
to aspirin users included eight studies that showed a pooled relative risk
of 0.87 for developing Alzheimer's disease"
NSAID Use Linked to Lower Rates of Breast Cancer - Doctor's Guide,
"Ten years or more of ibuprofen use reduced a
patient's risk nearly in half (RR=0.51, P<0.04), and just 1 to 4 years of
regular use was associated with a 29% reduction in risk. The effect of
acetylsalicylic acid (Aspirin) was weaker, with 10 years of use of
full-strength Aspirin associated with a 21% risk reduction that did not
achieve significance ... Neither acetaminophen nor low-dose Aspirin was
associated with a reduction in breast-cancer
risk ... he found the evidence of a chemoprotective effect compelling enough
to treat himself with 200 mg of ibuprofen per day" - See
ibuprofen at Amazon.com.
- NSAIDs No Help
as Alzheimer's Treatment - WebMD, 6/3/03 -
"Aisen's team tested the two drugs in 351 patients
with mild-to-moderate Alzheimer's disease. They looked for signs that the
drugs might slow mental decline or improve quality of life ... There was "no
consistent benefit of either treatment,""
NSAIDs May Protect Against Alzheimer's - Clinical Psychiatry News, 6/03
"Long-term use of NSAIDs—24 months or longer—was
associated with a significant protective effect"
NSAIDs Cause Ulcers and Bleeding in Small Intestine - Doctor's Guide,
"Research using video capsule endoscopy (VCE) shows
small intestinal ulcerations, lesions, and
bleeding related to the use of nonsteroidal anti-inflammatory drugs (NSAIDs)
occur 40% more often than previously thought"
More Migraine Relief Seen with Over-the-Counter Combination than with
Sumatriptan - Doctor's Guide, 4/4/03 -
"Patients are more likely to get relief from a
migraine episode if they use an over-the-counter (OTC) treatment that
aspirin, and caffeine at the first sign of
an attack than if they use 50 mg of
... Among the OTC subjects, 87% had responded to treatment at 2 hours,
compared to 75% of sumatriptan subjects (P=0.045). The differences seen 24
hours after treatment showed that 66% of the OTC subjects had sustained
relief, compared to 49% of the sumatriptan group" - See
drugstore.com acetaminophen products.
Non-Steroidal Anti-Inflammatory Drugs Appear To Protect Against Alzheimer's
- Doctor's Guide, 4/1/03 -
"compared with non-users, people who took any type
of NSAID were 28% less likely to develop
Alzheimer's, which was statistically significant. But, among
aspirin-only users, the risk of Alzheimer's was cut by 13%, which was
not significant" - See ibuprofen at Amazon.com
aspirin at Amazon.com.
- NSAIDS May Help
in Alzheimer's Prevention - WebMD, 4/1/03 -
"For those using aspirin,
the reduction in risk was 13%, a finding that was not considered significant
... Those on an NSAID for one to 23 months had a
risk reduction of 17%, and those termed long-term users, beyond 23 months,
reduced the risk of developing Alzheimer's disease by 73%" - See
ibuprofen at Amazon.com
aspirin at Amazon.com.
- NSAIDs May Reduce
Lung Cancer Risk - Medscape, 3/18/03 -
"using NSAIDs at least three times weekly for at
least one year decreased risk of lung carcinoma
by 32%, regardless of histology ... Aspirin had
similar smoking-specific risk estimates to those for all NSAIDs, but the
association of reduced lung cancer risk was found only in men and not in
women ... Although it is unclear why the protective effect of NSAIDs was
limited to smokers, the authors suggest that smoking might induce
cyclooxygenase (COX)-2 expression. Cigarette tar extracts increase COX
activity in rat lung cells, and COX-2 activity is higher in lung cancer
tissue of smokers than in nonsmokers" - [WebMD]
- See ibuprofen at Amazon.com
aspirin at Amazon.com.
NSAID Use Linked to Lower Incidence of Alzheimer's - Clinical Psychiatry
News, 1/03 -
"The largest reduction in risk was among former
users of NSAIDs or aspirin who had taken the
medications for 2 years or more. The incidence of
Alzheimer's disease in that group was 29% of the rate seen in nonusers"
- SSRIs May Increase
Risk of Gastrointestinal Bleeding - Medscape, 1/17/03 -
"Selective serotonin reuptake inhibitors (SSRIs)
are associated with an increased risk of gastrointestinal (GI) bleeding,
especially when combined with nonsteroidal anti-inflammatory drugs (NSAIDs)"
- Examples of SSRIs are Prozac,
- Pain Reliever
[Acetaminophen] Top Liver Failure Cause - WebMD, 12/16/02 -
"Although there is no medical data to suspect it
poses danger at recommended amounts, the active ingredient in Tylenol is so
toxic at high doses that a new study indicates that acetaminophen overdose
has become the leading cause of sudden liver failure"
Nonsteroidal Anti-Inflammatories, Acetaminophen Associated With Increased
Risk For Hypertension Among Women - Doctor's Guide, 11/19/02 -
"A substantial proportion of
hypertension in women may be due to the use of acetaminophen and
nonsteroidal anti-inflammatory drugs (NSAIDs) ... Compared with nonusers,
the relative risk of hypertension for women taking NSAIDs at least 22 days a
month was 1.86 while the relative risk for those taking acetaminophen at
least 22 days a month was 2.00, they reported ... Use of NSAIDs and use of
acetaminophen were significantly associated with increased risk of
aspirin use was not"
Nonsteroidal Anti-Inflammatory Drugs May Protect Against Parkinson's Disease
- Doctor's Guide, 11/14/02 -
"Studies show that NSAIDs can reduce
neuron degeneration in
Non Steroidal Anti-Inflammatories Decrease Risk Of Recurrent Myocardial
Infarction In Patients Taking Aspirin - Doctor's Guide, 10/30/02 -
"Patients taking aspirin
who were also taking NSAIDs were significantly
less likely to experience recurrent AMI
than those who took only aspirin" - I've got that. See
$8.99 for 500 of 200 mg of ibuprofen. and
$2.50 for 120 of the 81 mg aspirin.
Pain Relievers May Have Pressure Link - Intelihealth, 10/28/02
Anti-inflammatory Drugs May Require Two Years' Treatment to Prevent
Colorectal Cancer - Doctor's Guide, 10/22/02 -
aspirin or an NSAID for at least two years
reduced the risk of colorectal cancer by 32
Non-steroidal Anti-inflammatory Drug Use May Slow Breast Cancer Tumour
Growth, Prevent Distant Metastasis - Doctor's Guide, 9/30/02 -
"increasing NSAID use may retard the growth of
breast tumours and may prevent distant metastasis"
- Pain Relievers
May Prevent Alzheimer's - WebMD, 9/23/02 -
"The study found people who took
aspirin or other NSAIDs for more than two years before the study began
were 45% less likely to develop Alzheimer's
than those who didn't. And the longer the participants had taken the drugs,
the more protected they were against the disease ... previous studies have
suggested that aspirin and other NSAIDs might protect against Alzheimer's
disease by reducing inflammation in the
brain ... their findings show that the beneficial effects of NSAIDs in
preventing Alzheimer's take a long time to accumulate and don't become
apparent until years later"
- New Warning Labels
for Acetaminophen - WebMD, 9/20/02 -
"The warnings would urge consumers to take only the
recommended doses because exceeding them could cause serious liver damage
... Another issue is that drugstore shelves are bursting with products that
contain acetaminophen -- more than 200 of them. Each of these remedies is
safe by itself. But people who take more than one product at a time may
unknowingly get an overdose"
Scientists Examine Long-Term Risks And Gains Of Painkillers -
Intelihealth, 1/22/02 -
"The studies reflect scientists' growing interest in
the idea that a common condition, inflammation, may underlie many chronic
and debilitating diseases - like Alzheimer's, heart disease, osteoporosis
and diabetes - and that drugs that fight inflammation may have a role in
preventing or delaying those diseases, or at least slowing them down ...
Originally, the effect was attributed to aspirin's ability to prevent blood
clots, which can cause heart attacks or strokes. But now, researchers think
part of the protective effect may come from aspirin's ability to quell
inflammation in the arteries, helping to prevent blockages"
- An Aspirin a Day
to Keep Prostate Cancer Away? - WebMD, 6/7/01 -
"A growing body of research has suggested that
people who regularly take aspirin and other NSAIDs have a lower risk for
cancers, including breast cancer and colon cancer. And though the definitive
word is not in, new research presented at the annual meeting of the American
Urological Association suggests that regular NSAID use can reduce the risk
of prostate cancer too"
Use as Directed, Health Officials Concerned About Accidental Overdoses -
WebMD, 3/29/01 -
"Lee's database now includes 300 cases of liver
failure, of which he has linked about 38% to acetaminophen-related products"
FDA Probes New Acetaminophen Worry - Intelihealth, 3/27/01 -
"There are warnings not to take it if you consume
more than three alcoholic drinks ... acetaminophen overdoses could be a
bigger cause of liver failure than some prescription drugs recently banned
for liver poisoning, such as the diabetes medicine Rezulin ... He tracked
more than 300 acute liver failure cases at 22 hospitals and linked 38
percent to acetaminophen ... In a second database tracking 307 adults
suffering severe liver injury - not full-fledged failure - at six hospitals,
Lee linked acetaminophen to 35 percent of cases ... initial symptoms are
flu-like and doctors may not promptly test for acetaminophen's hallmark
sky-high liver enzymes"
FDA probes danger of acetaminophen overdose - USA Today, 3/26/01
drugs linked to risk of lung defect - USA Today, 3/7/01 -
"pregnant women who took aspirin, ibuprofen or
naproxen, all non-steroidal anti-inflammatory drugs, or NSAIDs, were far
more likely to deliver newborns with persistent pulmonary hypertension, or
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