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Welcome to the Quality Counts. For those health conscious consumers and medical professionals that are looking to purchase nutritional supplements, vitamins, herbs, learning about medications, losing weight, health food, low carbs, high protein nutrition, and exercise, you have come to the right place. Quality Counts serves both the medical practitioner and consumer interested in nutritional therapy and alternative medicine.
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Anti-aging Research > Zinc
Zinc
Specific Recommendations:
News & Research:
- Why you need to go with a supplement with the right
calcium, magnesium, zinc, copper ratio such as Body Wise
Essential Calcium:
- Vitamin Regimen Can Prevent Blindness -
Intelihealth, 10/12/01 -
"High doses of zinc can cause anemia, but participants also took 2
milligrams of copper daily to counter that effect"
-
Zinc-Induced Copper Deficiency: A Report of Three Cases - Medscape,
2/2/05 - "Excess zinc ingestion is
among the causes of copper deficiency"
-
Treating Hair Loss Naturally - WebMD -
"taking too much zinc can also cause
a copper deficiency, which in turn can actually cause hair loss"
-
Magnesium--A Forgotten Mineral - Health &
Nutrition Breakthroughs, 9/97 -
"Excess calcium and phosphate also interfere with magnesium absorption.
(Thus, taking calcium supplements without adding magnesium could result in
magnesium deficiency.)"
-
Inhibitory effects of zinc on magnesium balance and magnesium absorption in
man - Medline, 10/94 - "the
overall effect of the high Zn intake of the three groups combined,
regardless of the Ca intake, was a highly significant decrease of Mg
absorption and of the Mg balance"
-
Zinc -- The Immune System's Missing Link? - Health & Nutrition
Breakthroughs, 12/97 -
"Supplementing with zinc is quite safe--its only significant side effect is
lowered copper levels in the body tissues, since the two minerals compete
for absorption. Considering zinc's safety, people should consider taking
zinc supplements, especially as they age--being sure to include copper in
the proper balance. Most practitioners who supplement their patients' diets
with zinc also recommend taking copper at a ratio of 10 mg to 15 mg zinc for
each milligram of copper."
-
Increasing the Good Cholesterol - Health & Nutrition Breakthrough, 1/99
- "Low copper levels, which can be
induced by taking more than 25 mg/day of zinc, may increase triglycerides as
well as reduce HDL levels.25 Zinc/copper ratios should be monitored."
-
Zinc
lozenges may shorten common cold duration, Finnish research suggests -
Science Daily, 7/26/11 - "Dr. Harri Hemila of the
University of Helsinki, Finland, carried out a meta-analysis of all the
placebo-controlled trials that have examined the effect of zinc lozenges on
natural common cold infections. Of the 13 trial comparisons identified, five
used a total daily zinc dose of less than 75 mg and uniformly those five
comparisons found no effect of zinc. Three trials used zinc acetate in daily
doses of over 75 mg, with the average indicating a 42% reduction in the
duration of colds. Five trials used zinc salts other than acetate in daily
doses of over 75 mg, with the average indicating a 20% decrease in the
duration of colds"
-
Denture wearers warned about risk of excess zinc consumption - Science
Daily, 3/4/11 - "Denture wearers are advised to pay
special attention to the amount of zinc they consume ...A single tube should
last three to 10 weeks with daily use, although actual usage depends on the
number of applications per day ... Over time, toxic levels of zinc could
cause a copper deficiency, which has been linked to neurological damage"
-
Zinc
reduces the burden of the common cold - Science Daily, 2/15/11 -
"In total, data from 15 trials, involving 1,360
people, were included. According to the results, zinc syrup, lozenges or
tablets taken within a day of the onset of cold symptoms reduce the severity
and length of illness. At seven days, more of the patients who took zinc had
cleared their symptoms compared to those who took placebos. Children who
took zinc syrup or lozenges for five months or longer caught fewer colds and
took less time off school. Zinc also reduced antibiotic use in children,
which is important because overuse has implications for antibiotic
resistance"
-
Antioxidant compound reduced incidence of colorectal metachronous adenomas
- Science Daily, 12/7/09 - "The researchers
randomized 411 participants to the placebo group or to receive an
antioxidant compound -- specifically selenomethionnine 200 μg, zinc 30 mg,
vitamin A 6,000 IU, vitamin C 180 mg and vitamin E 30 mg ... individuals who
consumed antioxidants had a 40 percent reduction in the incidence of
metachronous adenomas of the large bowel ... It is noteworthy that the
benefit observed after the conclusion of the trial persisted through 13
years of follow up"
-
Children With ADHD at Risk for Zinc and Copper Deficiency - Medscape,
11/3/09 - "this patient population is at risk for
low trace mineral status, including deficiencies in zinc and copper —
minerals that may play a crucial role in the production of dopamine,
norepinephrine, and melatonin, which regulates sleep ... Presented here at
the American Academy of Child & Adolescent Psychiatry 56th Annual Meeting, a
study conducted by investigators at the University of British Columbia and
the Children's and Women's Health Centre in Vancouver, Canada, showed among
44 children aged 6 to 12 years with ADHD, rates of zinc and copper
deficiency were 45% and 35%, respectively" - See
Jarrow Zinc Balance at iHerb
 .
-
Zinc
Deficiencies A Global Concern - Science Daily, 9/17/09 -
"One new study has found DNA damage in humans caused
by only minor zinc deficiency ... Zinc deficiency is quite common in the
developing world ... studies have shown that zinc is essential to protecting
against oxidative stress and helping DNA repair – meaning that in the face
of zinc deficiency, the body's ability to repair genetic damage may be
decreasing even as the amount of damage is going up ... When prostate glands
become cancerous, their level of zinc drops precipitously, and some studies
have suggested that increasing zinc in the prostate may at least help
prevent prostate cancer and could potentially be a therapeutic strategy.
There are concerns about the relationship of zinc intake to esophageal,
breast, and head and neck cancers. And the reduced zinc status that occurs
with aging may also contribute to a higher incidence of infection and
autoimmune diseases"
-
Got
Zinc? New Zinc Research Suggests Novel Therapeutic Targets - Science
Daily, 7/30/09 - "zinc not only supports healthy
immune function, but increases activation of the cells (T cells) responsible
for destroying viruses and bacteria ... It has been shown that zinc
supplementation significantly reduces the duration and severity of childhood
diarrhea, lower respiratory infections, and incidence of malaria in
zinc-deficient children ... Age-related declines in immune function have
also been related to zinc deficiency in the elderly ... T cells taken from
the zinc-supplemented group had higher activation than those from the
placebo group. Specifically, cell activation stimulated the zinc transporter
in T cells called "ZIP8," which transports stored zinc into the cell
cytoplasm where it then alters the expression of a T cell protein in a way
needed to fight infections" - See
Jarrow Zinc Balance at iHerb
(too much zinc can cause a copper deficiency.
-
Zinc
Supplements During Pregnancy May Counteract Damage From Early Alcohol
Exposure - Science Daily, 2/2/09 - "Animal
research has shown that binge drinking – even just once – during early
pregnancy can cause numerous problems for the fetus, including early
postnatal death. Fetal zinc deficiency may explain some of the birth defects
and neurodevelopmental abnormalities associated with alcohol exposure. New
rodent findings are the first to show that dietary zinc supplements
throughout pregnancy can reduce some alcohol-related birth defects"
-
Zinc
Reduces Common Cold Symptoms - Medscape, 4/17/08 -
"The participants took one zinc acetate lozenge
containing 13.3 mg of zinc or placebo every 2-3 hours while awake ... The
average duration of cold symptoms (including cough, nasal discharge, and
muscle ache) was significantly shorter in the zinc group (4.0 days) than in
the placebo group (7.1 days) ... By day 4, 56% of the zinc group had
complete resolution of their colds, whereas none of the placebo group was
free of cold symptoms on day 4"
-
Zinc
Linked To Macular Degeneration, Study Suggests - Science Daily, 8/27/07
- "In studying eye tissue samples, the researches
found that deposits, that are hallmarks of age-related macular degeneration
(AMD), contain large amounts of zinc ... The double-edged sword is that zinc
has been found to enhance the immune system, but also could play a role in
the advancement of macular degeneration"
- Zinc
Supplementation May Decrease Incidence of Infections in the Elderly -
Medscape, 3/13/07 - "After zinc
supplementation, the incidence of infections was significantly lower, plasma
zinc was significantly higher, and generation of tumor necrosis factor alpha
and oxidative stress markers was significantly lower in the
zinc-supplemented than in the placebo group"
-
Zinc
Plays Important Role In Brain Circuitry - Science Daily, 11/27/06 -
"By engineering a mouse with a
mutation affecting a neuronal zinc target ... The resulting mutant mice
showed tremors, delayed ability to right themselves when turned over,
abnormal gait, altered transmission of visual signals, and an enhanced
startle response to sudden noise"
-
Healthy Diet May
Help Seniors' Vision - WebMD, 12/27/05 -
"People with above-average intakes of
all four antioxidants were 35% less likely to develop AMD during the study
... Vitamin E and zinc stood out"
-
Zinc May Help Middle School Students' Thinking - WebMD, 4/4/05 -
"The seventh-graders who took 20
milligrams of zinc fared best. Their reaction times on a visual memory test
became 12% quicker, their scores on a word recognition test improved by 9%,
and their results on a task requiring sustained attention rose by 6%"
- Zinc Deficiency Linked to Increased Risk of Less-Common Form of Esophageal
Cancer - Doctor's Guide, 2/16/05 -
"zinc deficiency in humans is
associated with an increased risk of developing esophageal squamous
cell carcinoma, an often-fatal form of esophageal cancer that has about
7,000 cases a year"
-
Zinc Supplements May Guard Against Oral Cancers - HealthDay, 1/12/05
-
Efficacy of Zinc Against the Common Cold Virus - Medscape, 11/23/04 -
"Clinical trial data support the value of zinc in reducing the duration and
severity of symptoms of the common cold when administered within 24 hours of
the onset of common cold symptoms"
- Zinc May Be Key to Major Cause of Blindness -
HealthDay, 8/27/04 - "if there is
not enough zinc in the body or there is a mutation in the zinc binding site,
the protein rhodopsin
will misfold
and break down, triggering cell death, degeneration of the retina and
eventually blindness"
- Ocular Disorders Associated with Increased Risk of Mortality, But Zinc
Therapy Appears to Reduce Mortality - Doctor's
Guide, 5/12/04
- Zinc
Supplements Associated With Improved Survival -
Medscape, 5/10/04 - "Various ocular
disorders (eg,
visual impairment and cataract and those in persons with diabetes mellitus,
severe retinopathy, or visual impairment) have been reported to be
significant predictors of a decreased life span ... Compared with subjects
not taking zinc, those randomized to receive any zinc (zinc alone or with
antioxidants) had 27% lower mortality"
- Zinc supplements fail to meet quality standards -
Nutra USA, 4/13/04
- Zinc May Boost Effectiveness of Ritalin - WebMD,
4/8/04 - "children who took 55 mg of
zinc daily along with their Ritalin had better symptom control than children
given Ritalin and a dummy pill"
- Zinc to underpin ADHD treatment? - Nutra USA,
4/8/04 - "Zinc
supplements could increase the effectiveness of stimulants used to treat
children with attention deficit hyperactivity disorder"
- Zinc
Supplements (Lozenges, Pills, and Liquids) -
ConsumerLab.com, 4/7/04
- Zinc
May Increase Antidepressant Therapy Effectiveness
- Healthwell Exchange Daily News, 3/4/04 -
"the zinc-supplemented group showed a statistically significant improvement
compared with the placebo group at 6 and 12 weeks ... Other natural
substances that have been shown to benefit depression sufferers include
folic acid, DHEA, eicosapentaenoic acid (a fatty acid found in fish oil),
and St. John’s wort"
- Zinc
May Increase Stature in Some Growth Hormone-Deficient Children
- Healthwell Exchange Daily News, 10/16/03
-
Research Explores Zinc in Prostate Cancer - Natural Foods Merchandiser,
9/03 - "A new
study has found that men who take extremely high levels of supplemental zinc
double their risk of prostate cancer. The study found no increased risk for
men who take less than 100 mg of supplemental zinc a day"
-
The Chromium Connection - Natural Foods Merchandiser, 9/03 -
"The body requires certain nutrients to control glucose metabolism,
especially
chromium, zinc and vitamins B and
C"
- Too Much Zinc Linked to Prostate Cancer - WebMD,
7/1/03 - "although taking zinc
supplements of up to 100 mg per day did not increase men's overall risk of
prostate cancer, men who took more than 100 mg
of supplemental zinc per day were more than twice as likely to develop
advanced prostate cancer than nonusers ... they can't rule out the fact that
some other factor may account for the increase in advanced prostate cancer
risk associated with excessive zinc supplementation found by the study"
- Zinc interferes with copper absorption so maybe the cause is low copper.
- Zinc
Nasal Gel Reduces Duration and Severity of the Common Cold
- New Hope Natural Media, 5/22/03
- Zinc
Reduces the Severity of Tinnitus - New Hope
Natural Media, 4/17/03 - "The
current study examined the prevalence of zinc deficiency and the effect of
zinc therapy in people with
tinnitus. Forty-one people with tinnitus
participated in the study, and more than 31% of them were found to have zinc
deficiency. All of the participants were randomly assigned to receive either
50 mg of zinc or placebo daily. At the end of two months, 46% of the people
in the zinc group had clinical improvement, defined as a ten-decibel or
greater decrease in loudness of tinnitus"
- Copper-Zinc Superoxide Dismutase Helps Premature Infants
- Medscape, 3/7/03
- Zinc Spray Shortens Colds - WebMD, 1/7/03 -
"patients using Zicam, an over-the-counter nasal spray, cut the length of
their colds an average of 1.5 days compared with
those treated with a placebo. However, some patients slashed their cold
duration in half -- from six days to only three" - See
Zicam at drugstore.com
 .
- Zinc Gluconate Reduces Cold Duration And Frequency In Children
- Doctor's Guide, 11/14/02 -
"Subjects taking the zinc gluconate glycine lozenges [Cold-Eeze]
showed shorter cold duration than non-users: 7.5 and 9.0 days respectively.
Further, 4.1 percent of those taking the lozenge needed concomitant
antibiotics compared to 36.2 percent of non-users. Prophylaxis with the
lozenge reduced the median annual number of colds from 1.3 in non-users to
0.0 among the lozenge users" - I've got that via my drugstore.com
affiliate. See
Cold-Eeze
 .
Now might be a good time to stock up on
Zicam
so that you can use it at the first symptoms of a cold.
- Prenatal Zinc May Impair Infant Mental Development
- Doctor's Guide, 7/25/02
- Nuts
May Lower Risk of Diabetes - Medscape, 6/19/02 -
"In this prospective, double-blind, clinical interventional study, 56 obese
women with normal glucose tolerance were randomized to treatment with zinc,
30 mg daily, or placebo for four weeks ... Insulin resistance as measured by
a homeostasis model assessment did not change in the placebo group, but it
decreased from 5.8 ± 2.6 to 4.3 ± 1.7 (P<.05) in the zinc-supplemented
group. Insulin decreased from 28.8 ± 14.1 to 21.2 ± 8.1 mU/mL
(P<.05) in the zinc group but was unchanged in the placebo group"
-
Zinc Helps Kids Grow - WebMD, 5/24/02 -
"This new report looked at 33 studies on the effects of zinc supplementation
on children up to 10 years old that were published between 1976 and 2001 ...
Overall, zinc supplementation produced very significant positive effects on
both height and weight measures of the children. And the effect was even
greater among children who already suffered from stunted growth or were
underweight"
-
Supplements Boost Sperm Count - WebMD, 3/20/02 -
"Researchers found that the men with fertility problems who took 5 mg of
folic acid a day and 66 mg of zinc sulfate a day for 26 weeks had a 74%
increase in total normal sperm count"
-
Zinc Helps Sickle Cell Kids Grow - WebMD, 1/24/02
- Zinc Plays
Significant Role in Growth of Children with Sickle Cell Disease
- Doctor's Guide, 1/22/02
- Growth Benefits Of Zinc In Children With Sickle Cell Disease
- Intelihealth, 1/22/02
- Zinc Supplements Cut Infection, Reduce Risk Of Infant Death
- Intelihealth, 12/13/01 -
"zinc supplementation may lower the rate of childhood death caused by
diarrhea, respiratory infections, and other preventable illnesses in
developing nations around the world"
- Zinc Boosts Infant Survival Rates - Intelihealth,
12/3/01 - "After 14 days, the zinc
spray "pretty much had no effect at all," ... Don't think this means Zicam
-- a zinc gel spray on store shelves -- will or won't work, says Belongia.
"This is not the same formulation as Zicam""
-
Pour Your Zinc Down the Sink? - WebMD, 11/16/01
- Dietary
Supplements Reduce Risk of Vision Loss From Age-Related Macular Degeneration
- Doctor's Guide, 10/12/01
-
Zinc, Antioxidants Prevent Some Forms of Vision Loss - WebMD, 10/12/01 -
"people at risk of losing more sight due to a condition called "age-related
macular degeneration" (AMD) could prevent further vision loss by taking a
combination of zinc and antioxidants, including vitamins C and E and
beta-carotene ... The antioxidants were taken once a day at a dose of 500 mg
of vitamin C, 400 IU
of vitamin E, and 15 mg of beta-carotene. Zinc was given as 80 mg of zinc
oxide along with 2 mg of copper in the form of cupric oxide to prevent
anemia, which can occur from too much zinc ... the high levels of dietary
supplements that were taken in this study are very difficult to achieve from
diet alone"
-
Staying Young Forever, Putting new research findings into practice -
Life Extension Foundation, 12/99
- New Zinc Research Reveals More Applications -
Nutrition Science News, 7/01
- Mining Mineral Supplements - Nutrition Science
News, 7/01
- Zinc and Magnesium Deficiency Problems - Nutrition
Science News, 5/01 -
"zinc and magnesium are poorly absorbed when taken with calcium-containing
foods or supplements"
- ZMA: Is This Prohormone Alternative Worth it? -
Nutrition Science News, 5/01
-
Natural cures for the common cold? - CNN, 2/13/01 -
"a zinc nasal spray called Zicam, showed very promising results in a study
of 213 patients published in ENT, the Ear, Nose and Throat journal. Symptoms
were reduced by as much as 75 percent."
- Zinc
Supplements Important In Combating Diarrhea -
Doctor's Guide, 11/28/00
- Zinc Halts Colds - Nutrition Science News, 11/00
-
Bone Up on Osteoporosis - Nutrition Science News, 11/00
- ADHD A Modern Malady - Nutrition Science News,
8/00 - "Zinc levels also strongly
correlate to ADHD patients. Psychiatry department researchers at Technical
University in Turkey compared 48 ADHD children to 45 non-ADHD children.
While free fatty acid levels in blood serum were nearly four times lower in
ADHD children, mean serum zinc levels in ADHD patients were also less than
half the levels of the controls."
-
Drugs That Deplete- Nutrients That Heal - Life Extension Magazine, 7/00
- "Like magnesium, zinc can be
depleted by a variety of drugs. These include corticosteroids, oral
contraceptives, oral estrogens used in hormone replacement therapy
(including the designer estrogen raloxifene), ACE inhibitors such as Lotensil (benazepril) and Altace (ramipril), diuretics such as Hydrex
(benzthiazide), triamterene, and Bumex (bumetanide), the
cholesterol-lowering drug cholestyramine resin, and the anti-ulcer drug
Cimetidine."
-
Zinc Lozenges Cut Cold Duration in Half, Study Shows - WebMD, 8/14/00
-
Staying Young Forever, Putting new research findings into practice -
Life Extension Foundation, 12/99
-
Zinc, Not Iron, May Be the Answer to Anemia - Nutrition Science News,
11/99
- A Shield of Immunity - Nutrition Science News,
9/99
-
Essential Nutrients for Endurance Athletes - Nutrition Science News,
5/99
-
Zinc Found to Reduce Infant Mortality Risk - Intelihealth, 4/26/99
-
Second Sight - Nutrition Science News, 4/99
- Zinc
Supplementation Reduces Infectious Disease Morbidity - Doctor's Guide,
7/30/98
Abstracts:
-
Dietary
Intakes of Zinc and Heme Iron from Red Meat, but Not from Other Sources, Are
Associated with Greater Risk of Metabolic Syndrome and Cardiovascular Disease
- J Nutr. 2012 Jan 18 - "Participants, 45-84 y at
baseline (2000-2002), were followed through 2010 ... Participants, 45-84 y at
baseline (2000-2002), were followed through 2010. Diet was assessed by FFQ.
After adjusting for demographics and behavioral confounders, including BMI,
dietary vitamin E intake was inversely associated with incident MetS and CVD [HR
for extreme quintiles: MetS = 0.78 (95% CI = 0.62, 0.97), P-trend = 0.01; CVD:
HR = 0.69 (95% CI = 0.46, 1.03), P-trend = 0.04]. Intakes of heme iron and Zn
from red meat, but not from other sources, were positively associated with risk
of MetS [heme iron from red meat: HR = 1.25 (95% CI = 0.99,1.56), P-trend =
0.03; Zn from red meat: HR = 1.29 (95% CI = 1.03,1.61), P-trend = 0.04] and CVD
[heme iron from red meat: HR = 1.65 (95% CI = 1.10,2.47), P-trend = 0.01; Zn
from red meat: HR = 1.51 (95% CI = 1.02, 2.24), P-trend = 0.01]. Dietary intakes
of nonheme iron, Mg, vitamin C, and β-carotene were not associated with risk of
MetS, T2D, or CVD"
-
Dietary zinc
and prostate cancer survival in a Swedish cohort - Am J Clin Nutr. 2011 Jan
12 - "High dietary zinc intake was associated with a reduced risk of prostate
cancer-specific mortality (HR(Q4 vs Q1): 0.64; 95% CI: 0.44, 0.94; P for trend =
0.05) in the study population. The association was stronger in men with
localized tumors (HR: 0.24; 95% CI: 0.09, 0.66; P for trend = 0.005). Zinc
intake was not associated with mortality from other causes"
-
Subclinical
Zinc Deficiency in Alzheimer's Disease and Parkinson's Disease - Am J
Alzheimers Dis Other Demen. 2010 Sep 14 - "Results showed a significantly lower
blood zinc in patients with Alzheimer's and patients with Parkinson's than in
controls. Urine zinc excretion, normalized to urine creatinine excretion, was
not significantly different in either patient group compared to controls. These
patients are probably zinc deficient because of nutritional inadequacy" - Note:
Zinc interferes with copper and too much zinc can cause a deficiency of copper.
See
Jarrow Zinc Balance at iHerb.
-
Role of zinc
in the development and treatment of mood disorders - Curr Opin Clin Nutr
Metab Care. 2010 Aug 4 - "Not only has zinc deficiency
been shown to induce depression-like and anxiety-like behaviors, supplementation
has been used as a treatment for major depression. Zinc administration improves
the efficacy of antidepressant drugs in depressed patients and may have a
particular role to play in treatment-resistant patients. Recent investigations
into the molecular mechanisms responsible for these observations suggest a role
for zinc in the regulation of neurotransmitter systems, antioxidant mechanisms,
neurotrophic factors, and neuronal precursor cells"
-
Dietary zinc
intake is inversely related to subclinical atherosclerosis measured by carotid
intima-media thickness - Br J Nutr. 2010 May 21:1-10 -
"After adjustment for
potential confounders, the mean carotid IMT in the low Zn intake group was
higher than that in the high Zn intake group. When subclinical atherosclerosis
was defined as >80th percentile value of IMT or >/= 1 mm of carotid IMT, after
adjustment for potential confounders, Zn intake was inversely related to
subclinical atherosclerosis (5th v. 1st quintile, OR 0.64, 95 % CI 0.45, 0.90, P
for trend = 0.069; 5th v. 1st quintile, OR 0.34, 95 % CI 0.16, 0.70, P for trend
= 0.005, respectively). In persons free of clinical CVD, dietary Zn intake was
inversely correlated with subclinical atherosclerosis. The present findings
suggest a putative protective role of dietary Zn intake against the development
of atherosclerosis" - See
Jarrow Zinc Balance at iHerb
(zinc supplementation can cause a copper deficiency.
-
Zinc
decreases C-reactive protein, lipid peroxidation, and inflammatory cytokines in
elderly subjects: a potential implication of zinc as an atheroprotective agent
- Am J Clin Nutr. 2010 Apr 28 - "One group was given an
oral dose of 45 mg zinc/d as a gluconate for 6 mo ... These findings suggest
that zinc may have a protective effect in atherosclerosis because of its
antiinflammatory and antioxidant functions"
-
Zinc in
cancer prevention - Nutr Cancer. 2009 Nov;61(6):879-87 -
"Zinc not only
improves cell mediated immune functions but also functions as an antioxidant and
anti-inflammatory agent. Oxidative stress and chronic inflammation have been
implicated in development of many cancers. In patients with head and neck
cancer, we have shown that nearly 65% of these patients were zinc deficient
based on their cellular zinc concentrations. Natural killer (NK) cell activity
and IL-2 generation were also affected adversely ... Zinc status also correlated
with number of hospital admissions and incidences of infections. NF-kappa B is
constitutively activated in many cancer cells, and this results in activation of antiapoptotic genes, VEGF, cyclin DI, EGFR, MMP-9 and inflammatory cytokines.
Zinc inhibits NF-kappa B via induction of A-20. Thus, zinc supplementation
should have beneficial effects on cancer by decreasing angiogenesis and
induction of inflammatory cytokines while increasing apoptosis in cancer cells.
Based on the above, we recommend further studies and propose that zinc should be
utilized in the management and chemoprevention of cancer"
-
Effect
of zinc supplementation on mood states in young women: a pilot study -
Eur J Clin Nutr. 2010 Jan 20 - "multivitamins (MVs)
... who took MV and Zn showed a significant reduction in anger-hostility
score (P=0.009) and depression-dejection score (P=0.011) in the Profile of
Moods State (POMS) and a significant increase in serum Zn concentration
(P=0.008), whereas women who took only MV did not"
-
Effect
of contraceptive pill on the selenium and zinc status of healthy subjects
- Contraception. 2009 Jul;80(1):40-3 - "Use of OCP
resulted in a significant decrease in serum zinc levels (p</=.009, t=-3.666)
and alteration of selenium levels but not significantly (p=.08, t=0.935)"
-
Zinc
Deficiency Reduces Bone Mineral Density in the Spine of Young Adult Rats: A
Pilot Study - Ann Nutr Metab. 2009 Jun 9;54(3):218-226 -
"These findings indicate that severe zinc deficiency
initiated during adolescence may have important implications for future bone
health, especially with regards to bone consolidation in the spine"
-
Zinc
intake from supplements and diet and prostate cancer - Nutr Cancer.
2009;61(2):206-15 - "Ten-year average intake of
supplemental zinc was not associated with a reduced prostate cancer risk
overall (adjusted hazard ratio (HR) = 0.82 (95% confidence interval (CI)
0.58-1.14) for >15mg/day vs. nonuse, P for trend = 0.44); however, risk of
advanced prostate cancer (regionally invasive or distant metastatic, n =
123) decreased with greater intake of supplemental zinc (adjusted HR = 0.34,
95% CI = 0.13-1.09 for 10-yr average intake > 15 mg/day vs. nonuse, P for
trend = 0.04). Dietary zinc was not associated with prostate cancer. In this
prospective cohort, long-term supplemental zinc intake was associated with
reduced risk of clinically relevant advanced disease"
-
Vitamin
and mineral use and risk of prostate cancer: the case-control surveillance
study - Cancer Causes Control. 2008 Dec 18 -
"For use of multivitamins that did not contain zinc, the multivariable odds
ratios of prostate cancer were 0.6 for 1-4 years, 0.8 for 5-9 years, and 1.2
for 10 years or more, respectively (p for trend = 0.70). Men who used zinc
for ten years or more, either in a multivitamin or as a supplement, had an
approximately two-fold (OR = 1.9"
-
Serum zinc and pneumonia in nursing home elderly - Am J Clin Nutr. 2007
Oct;86(4):1167-1173 - "Normal serum zinc
concentrations in nursing home elderly are associated with a decreased
incidence and duration of pneumonia, a decreased number of new antibiotic
prescriptions, and a decrease in the days of antibiotic use. Zinc
supplementation to maintain normal serum zinc concentrations in the elderly
may help reduce the incidence of pneumonia and associated morbidity"
-
Effect of Zinc Supplementation on Thyroid Hormone Function. A Case Study of
Two College Females - Ann Nutr Metab. 2007 May 30;51(2):188-194 -
"Zinc supplementation appeared to
have a favorable effect on thyroid hormone levels, particularly total T(3),
and RMR"
-
Zinc and the Liver: An Active Interaction - Dig Dis Sci. 2007 Apr 6 -
"zinc could protect against liver
diseases"
-
Zinc supplementation decreases incidence of infections in the elderly:
effect of zinc on generation of cytokines and oxidative stress - Am J
Clin Nutr. 2007 Mar;85(3):837-44 -
"After zinc supplementation, the incidence of infections was significantly
lower, plasma zinc was significantly higher, and generation of tumor
necrosis factor alpha and oxidative stress markers was significantly lower
in the zinc-supplemented than in the placebo group"
-
Dietary Zinc and Prostate Cancer Risk: A Case-Control Study from Italy -
Eur Urol. 2007 Feb 5 - "In this
large study we found a direct association between high zinc intake and
prostate cancer risk, particularly for advanced cancers"
-
The prophylactic and therapeutic effectiveness of zinc sulphate on common
cold in children - Acta Paediatr. 2006 Oct;95(10):1175-81 -
"Compared to the placebo group, the
zinc group had shorter mean duration of cold symptoms and decreased total
severity scores for cold symptoms"
-
Immune-Enhancing Role of Vitamin C and Zinc and Effect on Clinical
Conditions - Annals of Nutrition and Metabolism 2006;50:85-94 -
"These trials document that adequate
intakes of vitamin C and zinc ameliorate symptoms and shorten the duration
of respiratory tract infections including the common cold"
-
Zinc intakes and plasma concentrations in men with
osteoporosis: the Rancho Bernardo Study - Am J
Clin Nutr. 2004 Sep;80(3):715-21 - "Dietary zinc intake
and plasma zinc each have a positive association with BMD in men"
-
Effect of zinc supplementation on antidepressant therapy in unipolar
depression: a preliminary placebo-controlled study
- Pol J Pharmacol. 2003 Nov-Dec;55(6):1143-7 -
"Zinc supplementation significantly reduced scores in both measures after 6-
and 12-week supplementation when compared with placebo treatment. This
preliminary study is the first demonstration of the benefit of zinc
supplementation in antidepressant therapy. The mechanism(s) may be related
to modulation of glutamatergic
or immune systems by zinc ion"
-
Zinc-Altered Immune Function - J. Nutr. 133:1452S-1456S, May 2003 -
"All kinds of
immune cells show decreased function after zinc
depletion ... Impaired immune functions due to zinc deficiency are shown to
be reversed by an adequate zinc supplementation, which must be adapted to
the actual requirements of the patient. High dosages of zinc evoke negative
effects on immune cells and show alterations that are similar to those
observed with zinc deficiency"
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