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Anti-aging Research > Zinc
News & Research:
- Why you need to go with a supplement with the right calcium, magnesium,
zinc, copper ratio:
Vitamin Regimen Can Prevent Blindness - Intelihealth, 10/12/01 -
"High doses of zinc can cause anemia, but
participants also took 2 milligrams of copper daily to counter that effect"
Zinc-Induced Copper Deficiency: A Report of Three Cases - Medscape,
2/2/05 - "Excess zinc ingestion is among the causes
of copper deficiency"
Treating Hair Loss Naturally - WebMD -
"taking too much zinc can also cause a copper
deficiency, which in turn can actually cause hair loss"
Magnesium--A Forgotten Mineral - Health & Nutrition Breakthroughs, 9/97
- "Excess calcium and phosphate also interfere with magnesium absorption.
(Thus, taking calcium supplements without adding magnesium could result in
Inhibitory effects of zinc on magnesium balance and magnesium absorption in
man - Medline, 10/94 - "the overall effect of
the high Zn intake of the three groups combined, regardless of the Ca
intake, was a highly significant decrease of Mg absorption and of the Mg
Zinc -- The Immune System's Missing Link? - Health & Nutrition
Breakthroughs, 12/97 -
"Supplementing with zinc is quite safe--its only
significant side effect is lowered copper levels in the body tissues, since
the two minerals compete for absorption. Considering zinc's safety, people
should consider taking zinc supplements, especially as they age--being sure
to include copper in the proper balance. Most practitioners who supplement
their patients' diets with zinc also recommend taking copper at a ratio of
10 mg to 15 mg zinc for each milligram of copper."
Increasing the Good Cholesterol - Health & Nutrition Breakthrough, 1/99
- "Low copper levels, which can be induced by taking
more than 25 mg/day of zinc, may increase triglycerides as well as reduce
HDL levels.25 Zinc/copper ratios should be monitored."
Zinc eaten at levels found in biofortified crops reduces 'wear and tear' on
DNA - Science Daily, 1/3/17 - "a modest 4
milligrams of extra zinc a day in the diet can have a profound, positive
impact on cellular health that helps fight infections and diseases. This
amount of zinc is equivalent to what biofortified crops like zinc rice and
zinc wheat can add to the diet of vulnerable, nutrient deficient populations
... Around much of the world, many households eat polished white rice or
highly refined wheat or maize flours, which provide energy but do not
provide enough essential micronutrients such as zinc. Zinc is an essential
part of nearly 3,000 different proteins, and it impacts how these proteins
regulate every cell in our body. In the absence of sufficient zinc, our
ability to repair everyday wear and tear on our DNA is compromised" -
Jarrow Zinc Balance at Amazon.com.
Zinc acetate lozenges may reduce the duration of the common cold by nearly 3
days, according to a recent analysis - Science Daily, 7/6/16 -
"Zinc acetate lozenges may reduce the duration of
the common cold by nearly 3 days ... Common cold patients should be
encouraged to try zinc acetate lozenges not exceeding 100 mg of elemental
zinc per day for treating their colds" - See
zinc acetate lozenges at Amazon.com.
deficiency linked to immune system response, particularly in older adults
- Science Daily, 3/23/15 - "When you take away zinc,
the cells that control inflammation appear to activate and respond
differently; this causes the cells to promote more inflammation ...
Approximately 12 percent of people in the U.S. do not consume enough zinc in
their diets. Of those 65 and older, closer to 40 percent do not consume
enough zinc ... Older adults tend to eat fewer zinc-rich foods and their
bodies do not appear to use or absorb zinc as well, making them highly
susceptible to zinc deficiency" - See
Jarrow Zinc Balance at Amazon.com.
Eight ways zinc affects the human body - Science Daily, 7/18/14 -
"Brain ... Cardiovascular System ... Liver ...
Pregnancy ... Diabetes ... Endocrine System ... Healing ... Pneumonia"
Jarrow Zinc Balance at Amazon.com.
Top 4 Foods for Thicker, Shinier Hair - ABC News, 4/29/14 -
"Zinc is a powerful nutrient for hair growth—it
helps accelerate the repair of damaged hair follicles, which keeps your hair
healthy through all of its growth phases. Zinc deficiency is also associated
with hair loss"
Deficiency-Associated Dermatitis in Infants - Medscape, 2/19/14 -
"Zinc deficiencies among infants are difficult to
identify for multiple reasons, including nonspecific signs and symptoms. The
most common signs of zinc deficiency disorder include dermatitis and growth
impairment, which can be attributed to multiple causes. Zinc deficiency
disorder–associated dermatitis, which is a physical manifestation, is
present in only the most severe cases. For premature infants, withdrawl of
the amount of blood required to measure the serum zinc level might
compromise the health of the infant; therefore, routine testing is not
performed, which might explain, in part, why no other cases were reported"
Depression Linked to
Low Zinc Levels in Blood - Medscape, 1/2/14 -
"The analysis included 17 studies that measured peripheral blood–zinc
concentrations in 1643 depressed patients and 804 control participants ...
mean peripheral blood–zinc concentrations were lower by approximately 1.85
µmol/L in depressed individuals compared with control participants ... More
severe depression was associated with greater differences in zinc levels
between depressed and control participants ... Zinc has antioxidant
properties, helps to maintain endocrine homeostasis and immune function, and
plays multiple roles in regulating the hippocampal and cortical
glutamatergic circuits that subserve affective regulation and cognitive
function. Thus, changes in zinc homeostasis might compromise neuroplasticity
and contribute to long-term neuropsychological and psychiatric decline"
discovery may shed light on Parkinson's, Alzheimer's - Science Daily,
9/30/13 - "If low zinc supply has the same effect on
human cells as on yeast, zinc deficiency might contribute to human diseases
that are associated with a build-up of "junked" proteins, such as
Parkinson's and Alzheimer's" - See
zinc supplements at Amazon.com.
Zinc Protects Against
Diabetes-Induced Changes in the Aorta - Medscape, 6/4/13 -
"These results suggest that zinc supplementation
provides a significant protection against diabetes-induced pathogenic
changes in the aorta without gender difference in the type 1 diabetic mouse
model. The aortic protection by zinc against diabetes-induced pathogenic
changes is associated with the up-regulation of both MT and Nrf2 expression"
lozenges may shorten common cold duration, Finnish research suggests -
Science Daily, 7/26/11 - "Dr. Harri Hemila of the
University of Helsinki, Finland, carried out a meta-analysis of all the
placebo-controlled trials that have examined the effect of zinc lozenges on
natural common cold infections. Of the 13 trial comparisons identified, five
used a total daily zinc dose of less than 75 mg and uniformly those five
comparisons found no effect of zinc. Three trials used zinc acetate in daily
doses of over 75 mg, with the average indicating a 42% reduction in the
duration of colds. Five trials used zinc salts other than acetate in daily
doses of over 75 mg, with the average indicating a 20% decrease in the
duration of colds"
Denture wearers warned about risk of excess zinc consumption - Science
Daily, 3/4/11 - "Denture wearers are advised to pay
special attention to the amount of zinc they consume ...A single tube should
last three to 10 weeks with daily use, although actual usage depends on the
number of applications per day ... Over time, toxic levels of zinc could
cause a copper deficiency, which has been linked to neurological damage"
reduces the burden of the common cold - Science Daily, 2/15/11 -
"In total, data from 15 trials, involving 1,360
people, were included. According to the results, zinc syrup, lozenges or
tablets taken within a day of the onset of cold symptoms reduce the severity
and length of illness. At seven days, more of the patients who took zinc had
cleared their symptoms compared to those who took placebos. Children who
took zinc syrup or lozenges for five months or longer caught fewer colds and
took less time off school. Zinc also reduced antibiotic use in children,
which is important because overuse has implications for antibiotic
Antioxidant compound reduced incidence of colorectal metachronous adenomas
- Science Daily, 12/7/09 - "The researchers
randomized 411 participants to the placebo group or to receive an
antioxidant compound -- specifically selenomethionnine 200 μg, zinc 30 mg,
vitamin A 6,000 IU, vitamin C 180 mg and vitamin E 30 mg ... individuals who
consumed antioxidants had a 40 percent reduction in the incidence of
metachronous adenomas of the large bowel ... It is noteworthy that the
benefit observed after the conclusion of the trial persisted through 13
years of follow up"
Children With ADHD at Risk for Zinc and Copper Deficiency - Medscape,
11/3/09 - "this patient population is at risk for
low trace mineral status, including deficiencies in zinc and copper —
minerals that may play a crucial role in the production of dopamine,
norepinephrine, and melatonin, which regulates sleep ... Presented here at
the American Academy of Child & Adolescent Psychiatry 56th Annual Meeting, a
study conducted by investigators at the University of British Columbia and
the Children's and Women's Health Centre in Vancouver, Canada, showed among
44 children aged 6 to 12 years with ADHD, rates of zinc and copper
deficiency were 45% and 35%, respectively" - See
Jarrow Zinc Balance at Amazon.com.
Deficiencies A Global Concern - Science Daily, 9/17/09 -
"One new study has found DNA damage in humans caused
by only minor zinc deficiency ... Zinc deficiency is quite common in the
developing world ... studies have shown that zinc is essential to protecting
against oxidative stress and helping DNA repair – meaning that in the face
of zinc deficiency, the body's ability to repair genetic damage may be
decreasing even as the amount of damage is going up ... When prostate glands
become cancerous, their level of zinc drops precipitously, and some studies
have suggested that increasing zinc in the prostate may at least help
prevent prostate cancer and could potentially be a therapeutic strategy.
There are concerns about the relationship of zinc intake to esophageal,
breast, and head and neck cancers. And the reduced zinc status that occurs
with aging may also contribute to a higher incidence of infection and
Zinc? New Zinc Research Suggests Novel Therapeutic Targets - Science
Daily, 7/30/09 - "zinc not only supports healthy
immune function, but increases activation of the cells (T cells) responsible
for destroying viruses and bacteria ... It has been shown that zinc
supplementation significantly reduces the duration and severity of childhood
diarrhea, lower respiratory infections, and incidence of malaria in
zinc-deficient children ... Age-related declines in immune function have
also been related to zinc deficiency in the elderly ... T cells taken from
the zinc-supplemented group had higher activation than those from the
placebo group. Specifically, cell activation stimulated the zinc transporter
in T cells called "ZIP8," which transports stored zinc into the cell
cytoplasm where it then alters the expression of a T cell protein in a way
needed to fight infections" - See
Jarrow Zinc Balance at Amazon.com
(too much zinc can cause a copper deficiency.
Supplements During Pregnancy May Counteract Damage From Early Alcohol
Exposure - Science Daily, 2/2/09 - "Animal
research has shown that binge drinking – even just once – during early
pregnancy can cause numerous problems for the fetus, including early
postnatal death. Fetal zinc deficiency may explain some of the birth defects
and neurodevelopmental abnormalities associated with alcohol exposure. New
rodent findings are the first to show that dietary zinc supplements
throughout pregnancy can reduce some alcohol-related birth defects"
Zinc Reduces Common Cold Symptoms - Medscape, 4/17/08 -
"The participants took one zinc acetate lozenge
containing 13.3 mg of zinc or placebo every 2-3 hours while awake ... The
average duration of cold symptoms (including cough, nasal discharge, and
muscle ache) was significantly shorter in the zinc group (4.0 days) than in
the placebo group (7.1 days) ... By day 4, 56% of the zinc group had
complete resolution of their colds, whereas none of the placebo group was
free of cold symptoms on day 4"
Linked To Macular Degeneration, Study Suggests - Science Daily, 8/27/07
- "In studying eye tissue samples, the researches
found that deposits, that are hallmarks of age-related macular degeneration
(AMD), contain large amounts of zinc ... The double-edged sword is that zinc
has been found to enhance the immune system, but also could play a role in
the advancement of macular degeneration"
Supplementation May Decrease Incidence of Infections in the Elderly -
Medscape, 3/13/07 - "After zinc supplementation, the
incidence of infections was significantly lower, plasma zinc was
significantly higher, and generation of tumor necrosis factor alpha and
oxidative stress markers was significantly lower in the zinc-supplemented
than in the placebo group"
Plays Important Role In Brain Circuitry - Science Daily, 11/27/06 -
"By engineering a mouse with a mutation affecting a
neuronal zinc target ... The resulting mutant mice showed tremors, delayed
ability to right themselves when turned over, abnormal gait, altered
transmission of visual signals, and an enhanced startle response to sudden
Healthy Diet May
Help Seniors' Vision - WebMD, 12/27/05 -
"People with above-average intakes of all four
antioxidants were 35% less likely to develop AMD during the study ...
Vitamin E and zinc stood out"
Zinc May Help Middle School Students' Thinking - WebMD, 4/4/05 -
"The seventh-graders who took 20 milligrams of zinc
fared best. Their reaction times on a visual memory test became 12% quicker,
their scores on a word recognition test improved by 9%, and their results on
a task requiring sustained attention rose by 6%"
Zinc Deficiency Linked to Increased Risk of Less-Common Form of Esophageal
Cancer - Doctor's Guide, 2/16/05 -
"zinc deficiency in humans is associated with an
increased risk of developing esophageal squamous cell carcinoma, an
often-fatal form of esophageal cancer that has about 7,000 cases a year"
Zinc Supplements May Guard Against Oral Cancers - HealthDay, 1/12/05
Efficacy of Zinc Against the Common Cold Virus - Medscape, 11/23/04 -
"Clinical trial data support the value of zinc in
reducing the duration and severity of symptoms of the common cold when
administered within 24 hours of the onset of common cold symptoms"
Zinc May Be Key to Major Cause of Blindness - HealthDay, 8/27/04 -
"if there is not enough zinc in the body or there is a mutation in the zinc
binding site, the protein rhodopsin will misfold and break down, triggering
cell death, degeneration of the retina and eventually blindness"
Ocular Disorders Associated with Increased Risk of Mortality, But Zinc
Therapy Appears to Reduce Mortality - Doctor's Guide, 5/12/04
- Zinc Supplements
Associated With Improved Survival - Medscape, 5/10/04 -
"Various ocular disorders (eg, visual impairment and cataract and those in
persons with diabetes mellitus, severe retinopathy, or visual impairment)
have been reported to be significant predictors of a decreased life span ...
Compared with subjects not taking zinc, those randomized to receive any zinc
(zinc alone or with antioxidants) had 27% lower mortality"
Zinc supplements fail to meet quality standards - Nutra USA, 4/13/04
- Zinc May Boost
Effectiveness of Ritalin - WebMD, 4/8/04 -
"children who took 55 mg of zinc daily along with their Ritalin had better
symptom control than children given Ritalin and a dummy pill"
Zinc to underpin ADHD treatment? - Nutra USA, 4/8/04 -
"Zinc supplements could increase the effectiveness of stimulants used to
treat children with attention deficit hyperactivity disorder"
- Zinc Supplements
(Lozenges, Pills, and Liquids) - ConsumerLab.com, 4/7/04
- Zinc May Increase
Antidepressant Therapy Effectiveness
- Healthwell Exchange Daily News, 3/4/04 -
"the zinc-supplemented group showed a statistically
significant improvement compared with the placebo group at 6 and 12 weeks
... Other natural substances that have been shown to benefit depression
sufferers include folic acid, DHEA, eicosapentaenoic acid (a fatty acid
found in fish oil), and St. John’s wort"
- Zinc May Increase
Stature in Some Growth Hormone-Deficient Children
- Healthwell Exchange Daily News, 10/16/03
Research Explores Zinc in Prostate Cancer - Natural Foods Merchandiser,
9/03 - "A new study has found that men who take
extremely high levels of supplemental zinc double their risk of prostate
cancer. The study found no increased risk for men who take less than 100 mg
of supplemental zinc a day"
The Chromium Connection - Natural Foods Merchandiser, 9/03 -
"The body requires certain nutrients to control
glucose metabolism, especially
chromium, zinc and vitamins B and
- Too Much Zinc
Linked to Prostate Cancer - WebMD, 7/1/03 -
"although taking zinc supplements of up to 100 mg per day did not increase
men's overall risk of
prostate cancer, men who took more than 100 mg
of supplemental zinc per day were more than twice as likely to develop
advanced prostate cancer than nonusers ... they can't rule out the fact that
some other factor may account for the increase in advanced prostate cancer
risk associated with excessive zinc supplementation found by the study"
- Zinc interferes with copper absorption so maybe the cause is low copper.
- Zinc Reduces the
Severity of Tinnitus - New Hope Natural Media, 4/17/03 -
"The current study examined the prevalence of zinc deficiency and the effect
of zinc therapy in people with
tinnitus. Forty-one people with tinnitus
participated in the study, and more than 31% of them were found to have zinc
deficiency. All of the participants were randomly assigned to receive either
50 mg of zinc or placebo daily. At the end of two months, 46% of the people
in the zinc group had clinical improvement, defined as a ten-decibel or
greater decrease in loudness of tinnitus"
- Zinc Spray
Shortens Colds - WebMD, 1/7/03 -
"patients using Zicam, an over-the-counter nasal
spray, cut the length of their colds an average
of 1.5 days compared with those treated with a placebo. However, some
patients slashed their cold duration in half -- from six days to only three"
Zinc Gluconate Reduces Cold Duration And Frequency In Children
- Doctor's Guide, 11/14/02 -
"Subjects taking the zinc gluconate glycine lozenges
showed shorter cold duration than non-users: 7.5 and 9.0 days respectively.
Further, 4.1 percent of those taking the lozenge needed concomitant
antibiotics compared to 36.2 percent of non-users. Prophylaxis with the
lozenge reduced the median annual number of colds from 1.3 in non-users to
0.0 among the lozenge users" - I've got that via my drugstore.com
Now might be a good time to stock up on
so that you can use it at the first symptoms of a cold.
Prenatal Zinc May Impair Infant Mental Development
- Doctor's Guide, 7/25/02
- Nuts May Lower Risk
of Diabetes - Medscape, 6/19/02 -
"In this prospective, double-blind, clinical
interventional study, 56 obese women with normal glucose tolerance were
randomized to treatment with zinc, 30 mg daily, or placebo for four weeks
... Insulin resistance as measured by a homeostasis model assessment did not
change in the placebo group, but it decreased from 5.8 +/- 2.6 to 4.3 +/-
1.7 (P<.05) in the zinc-supplemented group. Insulin decreased from 28.8 +/-
14.1 to 21.2 +/- 8.1 mU/mL (P<.05) in the zinc group but was unchanged in
the placebo group"
Zinc Helps Kids Grow - WebMD, 5/24/02 -
"This new report looked at 33 studies on the effects
of zinc supplementation on children up to 10 years old that were published
between 1976 and 2001 ... Overall, zinc supplementation produced very
significant positive effects on both height and weight measures of the
children. And the effect was even greater among children who already
suffered from stunted growth or were underweight"
Supplements Boost Sperm Count - WebMD, 3/20/02 -
"Researchers found that the men with fertility
problems who took 5 mg of folic acid a day and 66 mg of zinc sulfate a day
for 26 weeks had a 74% increase in total normal sperm count"
Zinc Supplements Cut Infection, Reduce Risk Of Infant Death
- Intelihealth, 12/13/01 -
"zinc supplementation may lower the rate of
childhood death caused by diarrhea, respiratory infections, and other
preventable illnesses in developing nations around the world"
Zinc Boosts Infant Survival Rates - Intelihealth, 12/3/01 -
"After 14 days, the zinc spray "pretty much had no effect at all," ... Don't
think this means Zicam -- a zinc gel spray on store shelves -- will or won't
work, says Belongia. "This is not the same formulation as Zicam""
Zinc, Antioxidants Prevent Some Forms of Vision Loss - WebMD, 10/12/01 -
"people at risk of losing more sight due to a
condition called "age-related macular degeneration" (AMD) could prevent
further vision loss by taking a combination of zinc and antioxidants,
including vitamins C and E and beta-carotene ... The antioxidants were taken
once a day at a dose of 500 mg of vitamin C, 400 IU of vitamin E, and 15 mg
of beta-carotene. Zinc was given as 80 mg of zinc oxide along with 2 mg of
copper in the form of cupric oxide to prevent anemia, which can occur from
too much zinc ... the high levels of dietary supplements that were taken in
this study are very difficult to achieve from diet alone"
Zinc and Magnesium Deficiency Problems - Nutrition Science News, 5/01 -
"zinc and magnesium are poorly absorbed when taken
with calcium-containing foods or supplements"
Natural cures for the common cold? - CNN, 2/13/01 -
"a zinc nasal spray called Zicam, showed very
promising results in a study of 213 patients published in ENT, the Ear, Nose
and Throat journal. Symptoms were reduced by as much as 75 percent."
- Zinc Supplements Important
In Combating Diarrhea - Doctor's Guide, 11/28/00
ADHD A Modern Malady - Nutrition Science News, 8/00 -
"Zinc levels also strongly correlate to ADHD patients. Psychiatry department
researchers at Technical University in Turkey compared 48 ADHD children to
45 non-ADHD children. While free fatty acid levels in blood serum were
nearly four times lower in ADHD children, mean serum zinc levels in ADHD
patients were also less than half the levels of the controls."
Drugs That Deplete- Nutrients That Heal - Life Extension Magazine, 7/00
- "Like magnesium, zinc can be depleted by a variety
of drugs. These include corticosteroids, oral contraceptives, oral estrogens
used in hormone replacement therapy (including the designer estrogen
raloxifene), ACE inhibitors such as Lotensil (benazepril) and Altace
(ramipril), diuretics such as Hydrex (benzthiazide), triamterene, and Bumex
(bumetanide), the cholesterol-lowering drug cholestyramine resin, and the
anti-ulcer drug Cimetidine."
Zinc-rich oysters as well
as zinc yeast- and astaxanthin-enriched food improved sleep efficiency and sleep
onset in a randomized controlled trial of healthy individuals - Mol Nutr
Food Res. 2016 Dec 25 - "These subjects were divided
into 4 groups: placebo, zinc-rich food, zinc- and astaxanthin-rich food, and
placebo supplemented with zinc-enriched yeast and astaxanthin oil. Compared with
the placebo group, the zinc-rich food group efficiently decreased the time
necessary to fall asleep and improved sleep efficiency, whereas the group that
ingested zinc-enriched yeast and astaxanthin oil significantly improved the
sleep onset latency" - See Nutrex Hawaii
BioAstin Hawaiian Astaxanthin, 120 Gel Caps supply, 4mg Astaxanthin per Serving
Jarrow Zinc Balance at Amazon.com.
Cut and paste from my 11/9/16 newsletter:
Clinical Study Shows AstaReal(R) Astaxanthin Effective in Reducing both Mental
and Physical Fatigue - yonhapnews.co.kr, 11/7/16 - "AstaReal®
astaxanthin significantly reduced perceived
symptoms of mental and physical fatigue compared
to the placebo. These included improvements in clarity of thinking,
concentration, motivation, and mood. Irritation and feeling of body heaviness
were reduced. In the calculation test, an increase in errors observed in the
placebo during the second half of the test was almost eliminated in the
astaxanthin group. Supplementation with astaxanthin also significantly reduced
salivary cortisol, a biomarker for stress"
USA] - See astaxanthin at Amazon.com.
Diabetic Rats with Leucine, Zinc, and Chromium: Effects on Function and
Histological Structure of Testes - Int J Vitam Nutr Res. 2016 Jul 5:1-11 -
"Administration of nutritional supplements to the
diabetic rats improved testes morphology and reversed, although not completely,
impairment of spermatogenesis. Treatment with nutritional supplements increased
testicular length, height, width, and volume. All treatments increased the
number of live sperm and the total number of epididymal sperm. Furthermore,
nutritional supplements increased diameter of tubules, height of epithelium, and
the number of cells in seminiferous tubules. These alleviating effects were more
pronounced in animals treated with the leucine-zinc-chromium combination. The
present results demonstrate beneficial effects of zinc, leucine, and chromium
supplements to improve testes morphology and to restore spermatogenesis in type
2 diabetic rats" - See BulkSupplements Pure L-Leucine Powder (1 Kilogram).
Zinc supplementation for
improving glucose handling in pre-diabetes: A double blind randomized placebo
controlled pilot study - Diabetes Res Clin Pract. 2016 May;115:39-46 -
"fasting blood glucose levels, (FBG) ... received either 30mg zinc sulphate
dispersible tablet or placebo, once daily for six months ... After six months,
the intervention group significantly improved their FBG concentration compared
to the placebo group (5.37±0.20mmol/L vs 5.69±0.26, p<0.001) as well as compared
to their own baseline (5.37±0.20mmol/L vs 5.8±0.09, p<0.001). Beta cell
function, insulin sensitivity and insulin resistance all showed a statistically
significant improvement as well" - See
Jarrow Zinc Balance at Amazon.com.
supplementation and the effects on metabolic status in gestational diabetes: A
randomized, double-blind, placebo-controlled trial - J Diabetes
Complications. 2015 Jul 4 - "zinc-supplemented patients
had reduced fasting plasma glucose (FPG) (-6.6±11.2 vs. +0.6±6.7mg/dL, P=0.005),
serum insulin levels (-1.3±6.6 vs. +6.6±12.2μIU/mL, P=0.003), homeostasis model
of assessment-insulin resistance (HOMA-IR) (-0.5±1.6 vs. +1.5±2.7, P=0.001),
homeostatic model assessment-Beta cell function (HOMA-B) (-0.7±25.0 vs.
+26.5±49.5, P=0.01) and increased quantitative insulin sensitivity check index
(QUICKI) (+0.01±0.01 vs. -0.01±0.02, P=0.004) compared with the placebo.
Additionally, significant differences in serum triglycerides (+13.6±61.4 vs.
+45.9±36.5mg/dL, P=0.01) and VLDL-cholesterol concentrations (+2.7±12.3 vs.
+9.2±7.3mg/dL, P=0.01) were observed following the administration of zinc
supplements compared with the placebo"
Iron and Zinc in Pre-Menopausal Women and Its Effects on Mood and Cognition: A
Systematic Review - Nutrients. 2014 Nov 14 - "iron
insufficiency has been associated with impairments in mood and cognition ... Ten
randomized controlled trials and one non-randomized controlled trial were found
to meet the inclusion criteria. Seven studies found improvements in aspects of
mood and cognition after iron supplementation. Iron supplementation appeared to
improve memory and intellectual ability in participants aged between 12 and 55
years in seven studies, regardless of whether the participant was initially iron
insufficient or iron-deficient with anaemia. The review also found three
controlled studies providing evidence to suggest a role for zinc supplementation
as a treatment for depressive symptoms, as both an adjunct to traditional
antidepressant therapy for individuals with a diagnosis of major depressive
disorder and as a therapy in its own right in pre-menopausal women with zinc
deficiency. Overall, the current literature indicates a positive effect of
improving zinc status on enhanced cognitive and emotional functioning" -
iron supplements at Amazon.com
Jarrow Zinc Balance at Amazon.com.
intake of magnesium is associated with increased externalising behaviours in
adolescents - Public Health Nutr. 2014 Nov 6:1-7 -
"Adequate Zn and Mg intakes may be beneficial for the prevention and treatment
of mental health problems, such as depression, anxiety and attention-deficit
hyperactivity disorder ... using a validated FFQ ... Higher dietary intake of Mg
(per sd increase) was significantly associated with reduced externalising
behaviours (β=-1.45; 95 % CI -2.40, -0.50; P=0.003). There was a trend towards
reduced externalising behaviours with higher Zn intake (per sd increase;
β=-0.73" - See
Jarrow Zinc Balance at Amazon.com
Magtein at Amazon.com.
extract and zinc containing nutritional food supplement prevents onset and
progression of age-related cataract in wistar rats - J Nutr Health Aging.
2014;18(5):524-30 - "In the group treated with combined formulation of grape
seed extract and Zincovit tablets, the formation of cataract was significantly
prevented. In the normal and selenite induced senile cataract control group, the
levels of lens oxidative stress markers, G6PD and ATP were substantially lower
than in the grape seed extract with Zincovit tablets treated group"
grape seed extract at Amazon.com
and Health Aid Zincovit - C (Zinc, Vit C & Propolis) - Blister Pack 60 Tablets.
zinc, iron, and other sociodemographic factors associated with behavior problems
in preschoolers - Nutrients. 2014 Jan 27;6(2):530-45 -
"low zinc levels alone (p = 0.024) and combined low zinc
and iron levels (p = 0.022) are significantly associated with increased reports
of total behavior problems" - See
zinc supplements at Amazon.com.
Absorption by Young Adults from Supplemental Zinc Citrate Is Comparable with
That from Zinc Gluconate and Higher than from Zinc Oxide - J Nutr. 2013 Nov
20 - "We used the double-isotope tracer method with 67Zn
and 70Zn to measure zinc absorption from zinc citrate given as supplements
containing 10 mg of zinc to 15 healthy adults without food and compared
absorption with that from zinc gluconate and zinc oxide (insoluble in water)
using a randomized, double-masked, 3-way crossover design. Median (IQR)
fractional absorption of zinc from zinc citrate was 61.3% (56.6-71.0) and was
not different from that from zinc gluconate with 60.9% (50.6-to 71.7).
Absorption from zinc oxide at 49.9% (40.9-57.7) was significantly lower than
from both other supplements"
between zinc intake and risk of digestive tract cancers: A systematic review and
meta-analysis - Clin Nutr. 2013 Oct 10 - "PUBMED and
EMBASE were searched up to April 2013 ... The pooled relative risk (RR) of
overall digestive tract cancers for the highest versus lowest categories of zinc
intake was 0.82 (95% CI: 0.70-0.96; p = 0.013). Comparing the highest with
lowest categories, higher zinc intake was significantly associated with reduced
colorectal cancer risk (pooled RR = 0.80, 95% CI: 0.70-0.92; p = 0.002), while
zinc intake was not statistically associated with gastric cancer risk (pooled RR
= 0.91, 95% CI: 0.64-1.29; p = 0.581) or esophageal cancer risk (pooled RR =
0.72, 95% CI: 0.44-1.17; p = 0.187). However, subgroup analyses showed that zinc
intake was significantly associated with esophageal cancer risk and gastric
cancer risk in Asia, but not in America and Europe"
supplementation in children and adolescents with acute leukemia - Eur J Clin
Nutr. 2013 Aug 21 - "The aim of this study was to
evaluate the effects of oral zinc supplementation on weight gain and infectious
episodes in children and adolescents with acute leukemia ... study included 38
patients ... it has become evident that supplementary zinc exerts a positive
effect on nutritional status as positive weight gain. Moreover, the number of
infection episodes was significantly reduced, possibly because of the immune
stimuli ... zinc supplementation can prevent some of the chemotherapy adverse
effects in children with leukemia, improving their quality of life"
Zinc as a
nutritional approach to bone loss prevention in an ovariectomized rat model
- Menopause. 2013 Apr 8 - "Forty-eight female Wistar
rats were assigned to four groups: control, zinc, ovariectomy (OVX), and OVX +
zinc ... Reduction in zinc and copper levels was observed in the bone tissues
and serum of the OVX group. Zinc administration restored these levels to normal.
Electron microscopic studies revealed a looser structure and resorbed areas in
ovariectomized rat cortical bone. Zinc administration restored bone tissue
morphology ... These findings suggest that changes in cortical bone attributed
to estrogen deficiency are arrested by zinc supplementation, which can be a
sustainable approach to improving bone health"
heme iron and zinc and colorectal cancer incidence: a meta-analysis of
prospective studies - Cancer Causes Control. 2013 Apr 9 -
"Eight studies on heme iron intake and six studies on
zinc intake met the inclusion criteria. The summary RR of CRC for the highest
versus the lowest intake was 1.14 (95 % CI = 1.04-1.24) for heme iron and 0.83
(95 % CI = 0.72-0.94) for zinc, respectively ... This meta-analysis suggests a
significant positive dose-response association of heme iron intake and a
significant inverse dose-response association of zinc intake with risk of CRC"
Supplementation Does Not Alter Sensitive Biomarkers of Copper Status in Healthy
Boys - J Nutr. 2013 Jan - "Traditional (plasma
copper and ceruloplasmin activity) and more sensitive biomarkers of copper
status, including erythrocyte SOD1 activity and the erythrocyte CCS:SOD1 protein
ratio, were unchanged in zinc-supplemented boys, demonstrating that copper
status was not depressed"
Intakes of Zinc and Heme Iron from Red Meat, but Not from Other Sources, Are
Associated with Greater Risk of Metabolic Syndrome and Cardiovascular Disease
- J Nutr. 2012 Jan 18 - "Participants, 45-84 y at
baseline (2000-2002), were followed through 2010 ... Participants, 45-84 y at
baseline (2000-2002), were followed through 2010. Diet was assessed by FFQ.
After adjusting for demographics and behavioral confounders, including BMI,
dietary vitamin E intake was inversely associated with incident MetS and CVD [HR
for extreme quintiles: MetS = 0.78 (95% CI = 0.62, 0.97), P-trend = 0.01; CVD:
HR = 0.69 (95% CI = 0.46, 1.03), P-trend = 0.04]. Intakes of heme iron and Zn
from red meat, but not from other sources, were positively associated with risk
of MetS [heme iron from red meat: HR = 1.25 (95% CI = 0.99,1.56), P-trend =
0.03; Zn from red meat: HR = 1.29 (95% CI = 1.03,1.61), P-trend = 0.04] and CVD
[heme iron from red meat: HR = 1.65 (95% CI = 1.10,2.47), P-trend = 0.01; Zn
from red meat: HR = 1.51 (95% CI = 1.02, 2.24), P-trend = 0.01]. Dietary intakes
of nonheme iron, Mg, vitamin C, and β-carotene were not associated with risk of
MetS, T2D, or CVD"
and prostate cancer survival in a Swedish cohort - Am J Clin Nutr. 2011 Jan
12 - "High dietary zinc intake was associated with a
reduced risk of prostate cancer-specific mortality (HR(Q4 vs Q1): 0.64; 95% CI:
0.44, 0.94; P for trend = 0.05) in the study population. The association was
stronger in men with localized tumors (HR: 0.24; 95% CI: 0.09, 0.66; P for trend
= 0.005). Zinc intake was not associated with mortality from other causes"
Zinc Deficiency in Alzheimer's Disease and Parkinson's Disease - Am J
Alzheimers Dis Other Demen. 2010 Sep 14 - "Results
showed a significantly lower blood zinc in patients with Alzheimer's and
patients with Parkinson's than in controls. Urine zinc excretion, normalized to
urine creatinine excretion, was not significantly different in either patient
group compared to controls. These patients are probably zinc deficient because
of nutritional inadequacy" - Note: Zinc interferes with copper and too
much zinc can cause a deficiency of copper. See
Jarrow Zinc Balance at Amazon.com.
Role of zinc
in the development and treatment of mood disorders - Curr Opin Clin Nutr
Metab Care. 2010 Aug 4 - "Not only has zinc deficiency
been shown to induce depression-like and anxiety-like behaviors, supplementation
has been used as a treatment for major depression. Zinc administration improves
the efficacy of antidepressant drugs in depressed patients and may have a
particular role to play in treatment-resistant patients. Recent investigations
into the molecular mechanisms responsible for these observations suggest a role
for zinc in the regulation of neurotransmitter systems, antioxidant mechanisms,
neurotrophic factors, and neuronal precursor cells"
intake is inversely related to subclinical atherosclerosis measured by carotid
intima-media thickness - Br J Nutr. 2010 May 21:1-10 -
"After adjustment for potential confounders, the mean
carotid IMT in the low Zn intake group was higher than that in the high Zn
intake group. When subclinical atherosclerosis was defined as >80th percentile
value of IMT or >/= 1 mm of carotid IMT, after adjustment for potential
confounders, Zn intake was inversely related to subclinical atherosclerosis (5th
v. 1st quintile, OR 0.64, 95 % CI 0.45, 0.90, P for trend = 0.069; 5th v. 1st
quintile, OR 0.34, 95 % CI 0.16, 0.70, P for trend = 0.005, respectively). In
persons free of clinical CVD, dietary Zn intake was inversely correlated with
subclinical atherosclerosis. The present findings suggest a putative protective
role of dietary Zn intake against the development of atherosclerosis" -
Jarrow Zinc Balance at Amazon.com
(zinc supplementation can cause a copper deficiency.
decreases C-reactive protein, lipid peroxidation, and inflammatory cytokines in
elderly subjects: a potential implication of zinc as an atheroprotective agent
- Am J Clin Nutr. 2010 Apr 28 - "One group was given an
oral dose of 45 mg zinc/d as a gluconate for 6 mo ... These findings suggest
that zinc may have a protective effect in atherosclerosis because of its
antiinflammatory and antioxidant functions"
cancer prevention - Nutr Cancer. 2009 Nov;61(6):879-87 -
"Zinc not only improves cell mediated immune
functions but also functions as an antioxidant and anti-inflammatory agent.
Oxidative stress and chronic inflammation have been implicated in development of
many cancers. In patients with head and neck cancer, we have shown that nearly
65% of these patients were zinc deficient based on their cellular zinc
concentrations. Natural killer (NK) cell activity and IL-2 generation were also
affected adversely ... Zinc status also correlated with number of hospital
admissions and incidences of infections. NF-kappa B is constitutively activated
in many cancer cells, and this results in activation of antiapoptotic genes,
VEGF, cyclin DI, EGFR, MMP-9 and inflammatory cytokines. Zinc inhibits NF-kappa
B via induction of A-20. Thus, zinc supplementation should have beneficial
effects on cancer by decreasing angiogenesis and induction of inflammatory
cytokines while increasing apoptosis in cancer cells. Based on the above, we
recommend further studies and propose that zinc should be utilized in the
management and chemoprevention of cancer"
of zinc supplementation on mood states in young women: a pilot study -
Eur J Clin Nutr. 2010 Jan 20 - "multivitamins (MVs)
... who took MV and Zn showed a significant reduction in anger-hostility
score (P=0.009) and depression-dejection score (P=0.011) in the Profile of
Moods State (POMS) and a significant increase in serum Zn concentration
(P=0.008), whereas women who took only MV did not"
of contraceptive pill on the selenium and zinc status of healthy subjects
- Contraception. 2009 Jul;80(1):40-3 - "Use of OCP
resulted in a significant decrease in serum zinc levels (p</=.009, t=-3.666)
and alteration of selenium levels but not significantly (p=.08, t=0.935)"
Deficiency Reduces Bone Mineral Density in the Spine of Young Adult Rats: A
Pilot Study - Ann Nutr Metab. 2009 Jun 9;54(3):218-226 -
"These findings indicate that severe zinc deficiency
initiated during adolescence may have important implications for future bone
health, especially with regards to bone consolidation in the spine"
intake from supplements and diet and prostate cancer - Nutr Cancer.
2009;61(2):206-15 - "Ten-year average intake of
supplemental zinc was not associated with a reduced prostate cancer risk
overall (adjusted hazard ratio (HR) = 0.82 (95% confidence interval (CI)
0.58-1.14) for >15mg/day vs. nonuse, P for trend = 0.44); however, risk of
advanced prostate cancer (regionally invasive or distant metastatic, n =
123) decreased with greater intake of supplemental zinc (adjusted HR = 0.34,
95% CI = 0.13-1.09 for 10-yr average intake > 15 mg/day vs. nonuse, P for
trend = 0.04). Dietary zinc was not associated with prostate cancer. In this
prospective cohort, long-term supplemental zinc intake was associated with
reduced risk of clinically relevant advanced disease"
and mineral use and risk of prostate cancer: the case-control surveillance
study - Cancer Causes Control. 2008 Dec 18 -
"For use of multivitamins that did not contain zinc, the multivariable odds
ratios of prostate cancer were 0.6 for 1-4 years, 0.8 for 5-9 years, and 1.2
for 10 years or more, respectively (p for trend = 0.70). Men who used zinc
for ten years or more, either in a multivitamin or as a supplement, had an
approximately two-fold (OR = 1.9"
Serum zinc and pneumonia in nursing home elderly - Am J Clin Nutr. 2007
Oct;86(4):1167-1173 - "Normal serum zinc
concentrations in nursing home elderly are associated with a decreased
incidence and duration of pneumonia, a decreased number of new antibiotic
prescriptions, and a decrease in the days of antibiotic use. Zinc
supplementation to maintain normal serum zinc concentrations in the elderly
may help reduce the incidence of pneumonia and associated morbidity"
Effect of Zinc Supplementation on Thyroid Hormone Function. A Case Study of
Two College Females - Ann Nutr Metab. 2007 May 30;51(2):188-194 -
"Zinc supplementation appeared to have a favorable
effect on thyroid hormone levels, particularly total T(3), and RMR"
Zinc and the Liver: An Active Interaction - Dig Dis Sci. 2007 Apr 6 -
"zinc could protect against liver diseases"
Zinc supplementation decreases incidence of infections in the elderly:
effect of zinc on generation of cytokines and oxidative stress - Am J
Clin Nutr. 2007 Mar;85(3):837-44 -
"After zinc supplementation, the incidence of
infections was significantly lower, plasma zinc was significantly higher,
and generation of tumor necrosis factor alpha and oxidative stress markers
was significantly lower in the zinc-supplemented than in the placebo group"
Dietary Zinc and Prostate Cancer Risk: A Case-Control Study from Italy -
Eur Urol. 2007 Feb 5 - "In this large study we found
a direct association between high zinc intake and prostate cancer risk,
particularly for advanced cancers"
The prophylactic and therapeutic effectiveness of zinc sulphate on common
cold in children - Acta Paediatr. 2006 Oct;95(10):1175-81 -
"Compared to the placebo group, the zinc group had
shorter mean duration of cold symptoms and decreased total severity scores
for cold symptoms"
Immune-Enhancing Role of Vitamin C and Zinc and Effect on Clinical
Conditions - Annals of Nutrition and Metabolism 2006;50:85-94 -
"These trials document that adequate intakes of
vitamin C and zinc ameliorate symptoms and shorten the duration of
respiratory tract infections including the common cold"
Zinc intakes and plasma concentrations in men with osteoporosis: the Rancho
Bernardo Study - Am J Clin Nutr. 2004 Sep;80(3):715-21 -
"Dietary zinc intake and plasma zinc each have a positive association with
BMD in men"
Effect of zinc supplementation on antidepressant therapy in unipolar
depression: a preliminary placebo-controlled study
- Pol J Pharmacol. 2003 Nov-Dec;55(6):1143-7 -
"Zinc supplementation significantly reduced scores
in both measures after 6- and 12-week supplementation when compared with
placebo treatment. This preliminary study is the first demonstration of the
benefit of zinc supplementation in antidepressant therapy. The mechanism(s)
may be related to modulation of glutamatergic or immune systems by zinc ion"
Zinc-Altered Immune Function - J. Nutr. 133:1452S-1456S, May 2003 -
"All kinds of
immune cells show decreased function after zinc
depletion ... Impaired immune functions due to zinc deficiency are shown to
be reversed by an adequate zinc supplementation, which must be adapted to
the actual requirements of the patient. High dosages of zinc evoke negative
effects on immune cells and show alterations that are similar to those
observed with zinc deficiency"
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