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Recent Longevity News for the seven days ending 11/23/11.  You should consult your doctor if you are taking any medications.

Your daily cup of coffee may be aging your skin - MSNBC, 11/22/11 - Four minute video on skin health.

FDA Approves Gel Dermal Filler for Facial Wrinkles - Medscape, 11/21/11 - "The product combines a cohesive polydensified matrix technology with a hyaluronic acid base that attracts water to the injected area to fill and plump the wrinkle in natural way ... Potential treatment areas include nasolabial folds, worry lines, crow's feet, lips/chin/cheek augmentation, marionette lines, smile lines, perioral lines, and wrinkles at the décolletage ... According to information on the company Web site, patients are able to see the lines and wrinkles on their face softening and becoming less noticeable immediately after treatment. Results improve during the first week or so and continue for about 6 to 12 months before additional treatments are needed"

Joint Supplements for Aromatase Inhibitor Adverse Effects - Medscape, 11/18/11 - "Aromatase inhibitors are widely used in the treatment of breast cancer but are associated with significant musculoskeletal adverse effects, including joint pain and stiffness ... We know that these symptoms are unresponsive to conventional pain medication and often lead to low adherence to aromatase inhibitor therapy ... The cohort consisted of postmenopausal breast cancer patents with stage I to III disease who had been on aromatase therapy for at least 3 months, who reported a pain rating of 4 or higher on a 10-point visual analog scale, and whose pain worsened after initiating treatment with aromatase inhibitors if they had preexisting osteoarthritis ... Participants took 1500 mg/day of glucosamine and 1200 mg/day of chondroitin, and were evaluated every 6 weeks at the clinic ... There was a drop in pain and stiffness in the hips and knees at 12 and 24 weeks, as well as improvement in function. "This affected about 50% of the women," she explained. "We saw a very similar pattern looking at the hands and the wrist. We saw similar results with the Brief Pain/Stiffness Inventory — with about 35% to 50% of women."" - See glucosamine products at Amazon.com and chondroitin sulfate at Amazon.com.

Probiotics appear to mitigate pancreatitis: Surprising hypothetical mechanism warrants further investigation - Science Daily, 11/16/11 - "The major finding: in the small intestine, higher than normal numbers of the newly discovered bacterium, "commensal rat ileum bacterium" (CRIB) were correlated with reduced severity of acute pancreatitis in animals that had been fed probiotic. These animals had less infection of remote organs, less infection of dying and dead pancreatic tissues, and less severe immune response during acute pancreatitis, as demonstrated by lower plasma levels of proinflammatory cytokines" - See probiotics at Amazon.com.

Probiotic protects intestine from radiation injury - Science Daily, 11/16/11 - "the therapy can kill both cancer cells and healthy ones, leading to severe bouts of diarrhea if the lining of the intestine gets damaged ... For many patients, this means radiation therapy must be discontinued, or the radiation dose reduced, while the intestine heals ... Probiotics may provide a way to protect the lining of the small intestine from some of that damage ... the probiotic bacteria Lactobacillus rhamnosus GG (LGG), among other Lactobacillus probiotic strains, protected the lining of the small intestine in mice receiving radiation ... the probiotic was effective only if given to mice before radiation exposure ... The bacteria we use is similar to what's found in yogurt or in commercially available probiotics ... So theoretically, there shouldn't be risk associated with this preventative treatment strategy any more than there would be in a patient with abdominal cancer eating yogurt" - See probiotics at Amazon.com.

Milk thistle extract stops lung cancer in mice, study shows - Science Daily, 11/15/11 - "Compared to these multi-million dollar drugs, naturally-occurring silibinin blocked not only the expression of COX2 and iNOS, but also the migration of existing lung cancer cells" - See silymarin at Amazon.com.

Low vitamin D levels may be associated with recurrent inflammatory spinal cord disease - Science Daily, 11/14/11 - "The study found that vitamin D levels were significantly lower in patients who developed recurrent spinal cord disease. "Our findings suggest that there may be an association between lower total 25-hydroxyvitamin D levels in patients with recurrent TM/NMO/NMO spectrum disorders as compared with their counterparts with monophasic disease," ... This is consistent with other recurrent autoimmune conditions and points to a common link between low vitamin D levels and immunologic dysregulation" - See vitamin D at Amazon.com.

Abstracts from this week's Doctor's Guide Nutrition/Dietetics plus abstracts from my RSS feeds (Click here for the journals, the PubMed ones at the top):

Effects of coenzyme Q10 on vascular endothelial function in humans: A meta-analysis of randomized controlled trials - Atherosclerosis. 2011 Oct 25 - "Coenzyme Q10 supplementation is associated with significant improvement in endothelial function. The current study supports a role for CoQ10 supplementation in patients with endothelial dysfunction" - See ubiquinol products at Amazon.com.

The association of antihypertensive medication use with risk of cognitive decline and dementia: a meta-analysis of longitudinal studies - Int J Clin Pract. 2011 Dec;65(12):1295-305 - "The association of antihypertensive medication use with cognitive decline (including mild cognitive impairment) or dementia (including Alzheimer's disease (AD), vascular dementia (VD) and any dementia) has still been an area of controversy ... The quantitative meta-analysis showed that there was no significant difference in incidence of AD (RR: 0.90, 95% confidence interval (CI): 0.79-1.03), cognitive decline (RR: 0.97; 95% CI: 0.92-1.03) and cognitive impairment (RR: 0.97; 95% CI: 0.92-1.03). The quantitative meta-analysis showed that the subjects with antihypertensive medication use were lower incidence of VD (RR: 0.67, 95% CI: 0.52-0.87) and any dementia (RR: 0.87; 95% CI: 0.77-0.96) than those without"

LCAT, HDL Cholesterol and Ischemic Cardiovascular Disease: A Mendelian Randomization Study of HDL Cholesterol in 54,500 Individuals - J Clin Endocrinol Metab. 2011 Nov 16 - "Low plasma HDL cholesterol levels robustly associated with increased risk of MI but genetically decreased HDL cholesterol did not. This may suggest that low HDL cholesterol levels per se do not cause MI"

Urinary Bisphenol A (BPA) Concentration Associates with Obesity and Insulin Resistance - J Clin Endocrinol Metab. 2011 Nov 16 - "Bisphenol A (BPA) is one of the world's highest-volume chemicals in use today. Previous studies have suggested BPA disturbs body weight regulation and promotes obesity and insulin resistance. But epidemiological data in humans were limited ... The participants in the highest quartile of BPA had the highest prevalence of generalized obesity [odds ratio (OR) = 1.50; 95% confidence interval (CI) = 1.15-1.97], abdominal obesity (OR = 1.28; 95% CI = 1.03-1.60), and insulin resistance (OR = 1.37; 95% CI = 1.06-1.77). In participants with BMI under 24 kg/m(2), compared with the lowest quartile, the highest quartile of BPA increased the prevalence of insulin resistance by 94% (OR = 1.94; 95% CI = 1.20-3.14), but this association was not observed in those with BMI of 24 kg/m(2) or higher"

Association between serum cholesterol and noncardiovascular mortality in older age - J Am Geriatr Soc. 2011 Oct;59(10):1779-85 - "Participants were evaluated for total cholesterol and subfractions and followed for mortality for a median of 13.9 years ... Age- and sex-adjusted analyses showed that each 1-mmol/L increase in total cholesterol was associated with an approximately 12% lower risk of noncardiovascular mortality (hazard ratio (HR) = 0.88, 95% confidence interval (CI) = 0.84-0.92, P < .001). Age group-specific analyses demonstrated that this association reached significance after the age of 65 and increased in magnitude across each subsequent decade. This was driven largely by non-high-density lipoprotein cholesterol (non-HDL-C) (HR = 0.89, 95% CI 0.85-0.93, P < .001) and was partly attributable to cancer mortality. Conversely, HDL-C was not significantly associated with noncardiovascular mortality (HR = 0.92, 95% CI 0.79-1.07, P = .26)"

Frequency of dairy consumption and functional disability in older persons - J Nutr Health Aging. 2011;15(9):795-800 - "of milk and milk products consumption were obtained using a food frequency questionnaire and functional disability was assessed using the instrumental activities of daily living (IADL) and ADL scales ... In men, dietary intake of dairy products was associated with a significantly reduced risk of IADL disability after controlling for known functional disability risk factors and other dietary factors (p for trend, 0.038). Compared with men who consumed dairy products < 1 time/week, those who consumed ≥ 1 time/day had a reduced risk of IADL disability (odds ratio [OR], 0.35; 95% confidence interval [CI], 0.13-0.91). Meanwhile, milk and milk products consumption was not significantly associated with ADL disability. In women, dairy products consumption was not significantly associated with physical disability"

Plasma 25-Hydroxyvitamin D and Risk of Pancreatic Cancer - Cancer Epidemiol Biomarkers Prev. 2011 Nov 15 - "Mean plasma 25(OH)D was lower in cases versus controls (61.3 vs. 64.5 nmol/L, P=0.005). In logistic regression models, plasma 25(OH)D was inversely associated with odds of pancreatic cancer. Participants in quintiles two through five had multivariable-adjusted odds ratios (OR [95% confidence intervals]) of 0.79 (0.56-1.10), 0.75 (0.53-1.06), 0.68 (0.48-0.97), and 0.67 (0.46-0.97); P-trend=0.03), respectively, compared to the bottom quintile. Compared to those with insufficient levels (25[OH]D<50 nmol/L), ORs were 0.75 (0.58-0.98) for subjects with relative insufficiency (25[OH]D 50-<75 nmol/L) and 0.71 (0.52-0.97) for those with sufficient levels (25[OH]D≥75 nmol/L). No increased risk was noted in subjects with 25(OH)D ≥100 nmol/L, as suggested in a prior study. In subgroup analyses, ORs for the top versus bottom quartile of 25(OH)D were 0.72 (0.48-1.08) for women, 0.73 (0.40-1.31) for men, and 0.73 (0.51-1.03) for Whites ... Low circulating 25(OH)D may predispose individuals to the development of pancreatic cancer" - See vitamin D at Amazon.com.

Effect of folic acid intervention on ALT concentration in hypertensives without known hepatic disease: a randomized, double-blind, controlled trial - Eur J Clin Nutr. 2011 Nov 16 - "A total of 480 participants with mild or moderate essential hypertension and without known hepatic disease were randomly assigned to three treatment groups: (1) enalapril only (10 mg, control group); (2) enalapril-FA tablet (10 mg enalapril combined with 0.4 mg of FA, low FA group); and (3) enalapril-FA tablet (10 mg enalapril combined with 0.8 mg of FA, high FA group), once daily for 8 weeks ... This report included 455 participants in the final analysis according to the principle of intention to treat. We found a significant reduction in ALT level in the high FA group (median (25th percentile, 75th percentile), -0.6 (-6.9, 2.0)IU/l, P=0.0008). Compared with the control group, the high FA group showed a significantly greater ALT-lowering response in men (median ALT ratio (ALT at week 8 to ALT at baseline; 25th percentile, 75th percentile): 0.93 (0.67, 1.06) vs 1.00 (0.91, 1.21), P=0.032), and in participants with elevated ALT (ALT>40 IU/l) at baseline. There was no difference in ALT lowering between the control and the low FA group" - See folic acid products at Amazon.com.

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