Recent Longevity News for the seven days ending 6/17/09.  You should consult your doctor if you are taking any medications.

CoQ10 may boost sperm quality: Study - Nutra USA, 6/16/09 - "randomly assigned them to receive a daily CoQ10 supplement (300 mg, Kaneka, Japan) or placebo for 26 weeks. This was followed by 30 weeks with no intervention ... The Tehran-based researchers reported a significant improvement in both sperm density and motility following supplements of the coenzyme. A positive association was also found with regards to sperm count. Further analysis showed an increase in the percent of normal forms of sperm" - [Abstract] - See ubiquinol products at Amazon.com.

Omega-3 plus AREDS supplement works for eye health: Study - Nutra USA, 6/16/09 - "Increased intake of DHA was associated with a 27 per cent reduction in the progression to advanced age-related macular degeneration (AMD), while EPA was linked to a 26 per cent reduction" - [Abstract] - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.

Supplement may be statin alternative for some - CNN, 6/16/09 - "Now a new study suggests that an over-the-counter dietary supplement [red yeast rice] sold at pharmacies and health-food stores may be a workable alternative for people who have statin-related muscle pain. It seems that when combined with diet and lifestyle changes, red yeast rice supplements can lower LDL, or bad cholesterol, levels by more than 20 percent without a substantial risk of muscle pain (also known as myalgia), according to a study published Monday in the Annals of Internal Medicine" - [Medscape] - See red yeast rice at Amazon.com.

Topical Fluorouracil Reduces Number of Actinic Keratoses, Improves Skin Damage - Doctor's Guide, 6/15/09 - "The number of actinic keratoses was significantly reduced following treatment, from an average of 11.6 lesions to an average of 1.5. Clinical evaluations also identified overall improvements in aging-related damage, including decreases in fine and course wrinkling, lentigines, hyperpigmentation, and sallowness" - [WebMD] - Not only that but if you get a prescription for it it only costs $250 per tube at drugstore.com.  Here's a cut and paste from my 6/3/09 newsletter that explains actinic keratoses:

• Skin Lesion Leads To More Cancer Types Than Once Believed - Science Daily, 6/2/09 - "Two-thirds of the patients who had developed squamous-cell carcinomas, a form of treatable skin cancer, could trace their cancer to actinic keratoses. One-third of patients who ended up with basal cell carcinoma, the most common form of skin cancer in the United States, could trace their cancers to actinic keratoses" - I do a lot of swimming and just had three of these frozen by a dermatologist even though I wear a sun block shirt (coolibar.com) and plaster both a high number sun block plus zinc oxide on my face.

Skip Breakfast, Get Fat - WebMD, 6/15/09 - "Forgoing the first meal of the day actually tricks your brain into thinking you want higher-calorie foods -- foods that can make you fat, or at least increase your risk for weight gain"

Treating Gum Disease May Help Rheumatoid Arthritis - WebMD, 6/12/09 - "It was exciting to find that if we eliminated the infection and inflammation in the gums, then patients with a severe kind of active rheumatoid arthritis reported improvement on the signs and symptoms of that disease"

Successful Weight Loss With Dieting Is Linked To Vitamin D Levels - Science Daily, 6/11/09 - "the authors found that baseline, or pre-diet, vitamin D levels predicted weight loss in a linear relationship. For every increase of 1 ng/mL in level of 25-hydroxycholecalciferol—the precursor form of vitamin D and a commonly used indicator of vitamin D status—subjects ended up losing almost a half pound (0.196 kg) more on their calorie-restricted diet. For each 1-ng/mL increase in the active or "hormonal" form of vitamin D (1,25-dihydroxycholecalciferol), subjects lost nearly one-quarter pound (0.107 kg) more ... Additionally, higher baseline vitamin D levels (both the precursor and active forms) predicted greater loss of abdominal fat" - See vitamin D at Amazon.com.

Symptoms Of Depression In Obese Children Linked To Elevated Cortisol - Science Daily, 6/11/09 - "There is evidence in adults that abnormal regulation of cortisol plays a role in both obesity and depression ... Cortisol levels in the saliva in the afternoon and evening correlated positively with symptoms of depression ... The more depressive symptoms that subjects reported, the higher the cortisol levels at those times"

Red-wine Polyphenol Called Resveratrol Demonstrates Significant Health Benefits - Science Daily, 6/11/09 - "The breadth of benefits is remarkable – cancer prevention, protection of the heart and brain from damage, reducing age-related diseases such as inflammation, reversing diabetes and obesity, and many more ... Resveratrol exhibits therapeutic potential for cancer chemoprevention as well as cardioprotection ... The simplest explanation is that resveratrol turns on the cell's own survival pathways, preventing damage to individual cells ... Further mechanisms help, including removing very reactive oxidants in the body and improving blood supply to cells ... Low doses of resveratrol improve cell survival as a mechanism of cardio- and neuro-protection, while high doses increase cell death" - See resveratrol products at Amazon.com.

Stress Makes Your Hair Go Gray - Science Daily, 6/11/09 - "Those pesky graying hairs that tend to crop up with age really are signs of stress, reveals a new report in the journal Cell"

Less Sleep Associated With High, Worsening Blood Pressure In Middle Age - Science Daily, 6/11/09 - "After excluding patients taking medication for high blood pressure and controlling for age, race and sex, the researchers found that individuals who slept fewer hours were significantly more likely to have higher systolic (top number) and diastolic (bottom number) blood pressure ... Each hour of reduction in sleep duration was associated with a 37 percent increase in the odds of developing high blood pressure"

Hormone Therapy Plus Physical Activity Reduce Belly Fat, Body Fat Percentage After Menopause - Science Daily, 6/10/09 - "Older women who take hormone therapy to relieve menopausal symptoms may get the added benefit of reduced body fat if they are physically active"

Stopping Diabetes Damage With Vitamin C - Science Daily, 6/10/09 - "While neither therapy produced desired results when used alone, the combination of insulin to control blood sugar together with the use of Vitamin C, stopped blood vessel damage caused by the disease in patients with poor glucose control" - See vitamin C products at Amazon.com.

Abstracts from this week's Doctor's Guide Nutrition/Dietetics plus abstracts from my RSS feeds (Click here for the journals, the PubMed ones at the top):

Efficacy of coenzyme Q10 on semen parameters, sperm function and reproductive hormones in infertile men - J Urol. 2009 Jul;182(1):237-48 - "were randomly assigned to receive 300 mg coenzyme Q10 (Kaneka, Osaka, Japan) orally daily (106 in group 1) or a similar placebo regimen (106 in group 2) during a 26-week period, followed by a 30-week treatment-free phase ... Coenzyme Q10 supplementation resulted in a statistically significant improvement in certain semen parameters" - See ubiquinol products at Amazon.com.

Does eating particular diets alter risk of age-related macular degeneration in users of the age-related eye disease study supplements? - Br J Ophthalmol. 2009 Jun 12 - "Independent of AREDS supplementation, higher intakes of DHA (>/= 64.0 vs. < 26.0 mg/d) (hazard ratio [HR] = 0.73, 95% confidence interval [CI], 0.57, 0.94), EPA (>/= 42.3 vs. < 12.7 mg/d) (HR = 0.74, 95% CI, 0.59, 0.94), and lower dGI (dGI, < 75.2 vs. >/= 81.5) (HR = 0.76, 95% CI, 0.60, 0.96) were associated with lower risk for progression to advanced AMD. Participants consuming lower dGI and higher DHA or EPA had the lowest risk (P for synergistic interaction < 0.001) ... Our findings show an association of consuming a diet rich in DHA with lower progression of early AMD" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.

Fish-oil supplementation induces antiinflammatory gene expression profiles in human blood mononuclear cells - Am J Clin Nutr. 2009 Jun 10 - "A high EPA+DHA intake changed the expression of 1040 genes, whereas HOSF intake changed the expression of only 298 genes. EPA+DHA intake resulted in a decreased expression of genes involved in inflammatory- and atherogenic-related pathways, such as nuclear transcription factor kappaB signaling, eicosanoid synthesis, scavenger receptor activity, adipogenesis, and hypoxia signaling. CONCLUSION: These results are the first to show that intake of EPA+DHA for 26 wk can alter the gene expression profiles of PBMCs to a more antiinflammatory and antiatherogenic status" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.

Serum 25-hydroxyvitamin D is related to indicators of overall physical fitness in healthy postmenopausal women - Menopause. 2009 Jun 6 - "Serum 25(OH)D was the common contributor to physical fitness indices (androidal fat mass, lean mass, balance, handgrip strength) in healthy postmenopausal women" - See vitamin D at Amazon.com.

Quercetin inhibits fatty acid and triacylglycerol synthesis in rat-liver cells - Eur J Clin Invest. 2009 Jun 8 - "In hepatocytes from normal rats, the quercetin-induced decrease in both de novo fatty acid and TAG synthesis, with a consequent reduction in VLDL-TAG formation, may represent a potential mechanism contributing to the reported hypotriacylglycerolemic effect of quercetin" - See quercetin at Amazon.com.

Low HDL-cholesterol is associated with the risk of stroke in elderly diabetic individuals: Changes in the risk for atherosclerotic diseases at various ages - Diabetes Care. 2009 Jun 9 - "IHD and CVD occurred in 1.59% and 1.43% of participants over 2-year period. The relation of lower HDL-cholesterol and/or higher LDL-cholesterol to occurrence of IHD in subjects<65 y.o. was significant. Lower HDL-cholesterol was also significantly related to CVD in subjects >=65y.o. and especially those>=75 y.o. (n=1016; odds ratio, 0.511*; 95%CI, 0.239- 0.918, *P<0.05). Stepwise multiple regression analysis with onset of CVD as a dependent variable showed same result. Conclusion: Lower HDL-cholesterol is an important risk factor for not only IHD but also CVD, especially in the diabetic elderly" - See niacin at Amazon.com (niacin increases HDL).

Combination of vitamin K(2) and angiotensin-converting enzyme inhibitor ameliorates cumulative recurrence of hepatocellular carcinoma - J Hepatol. 2009 May 15 - "A 48-month follow-up revealed that the combination treatment with VK and ACE-I markedly inhibited the cumulative recurrence of HCC in association with suppression of the serum level of the vascular endothelial growth factor (VEGF); a central angiogenic factor. The serum level of lectin-reactive alpha-fetoprotein was also suppressed almost in parallel with VEGF. These beneficial effects were not observed with single treatment using VK or ACE-I" - See vitamin K at Amazon.com.

Effect of contraceptive pill on the selenium and zinc status of healthy subjects - Contraception. 2009 Jul;80(1):40-3 - "Use of OCP resulted in a significant decrease in serum zinc levels (p</=.009, t=-3.666) and alteration of selenium levels but not significantly (p=.08, t=0.935)"

Effect of Coffee and Green Tea Consumption on the Risk of Liver Cancer: Cohort Analysis by Hepatitis Virus Infection Status - Cancer Epidemiol Biomarkers Prev. 2009 Jun;18(6):1746-1753 - "Compared with almost never drinkers, increased coffee consumption was associated with a reduced risk of liver cancer in all subjects (hazard ratio for <1, 1-2, and >/=3 cups/d; P(trend) = 0.67, 0.49, 0.54, and 0.025). A similar risk tendency was observed in those with either or both HCV and HBV infection. In contrast, no association was observed between green tea consumption and the risk of liver cancer in all subjects"

Pioglitazone Improves Endothelial Function with Increased Adiponectin and High-density Lipoprotein Cholesterol Levels in Type 2 Diabetes - Endocr J. 2009 Jun 9 - "After treatment, HbA1c levels equally decreased in both groups, but PIO-treated group had significantly increased high-density lipoprotein cholesterol (HDL-C) levels, and decreased triglyceride, fasting insulin levels and HOMA-R. After treatment, increases in %FMD, plasma HDL-C and adiponectin (APN) levels were significantly greater in PIO-treated group than those in control group. Changes of %FMD showed significant positive correlations with those of plasma APN and HDL-C levels. In conclusion, the present study showed that treatment of T2DM improved endothelial function with greater increases in %FMD, APN and HDL-C levels in PIO-treated group than those in control group, suggesting the beneficial effect of PIO on endothelial function in T2DM" - See pioglitazone at OffshoreRx1.com.  Some may think I'm crazy but I still take pioglitazone for antiaging (decreasing advanced glycation end products, decrease chances of diabetes in addition to above).

Zinc Deficiency Reduces Bone Mineral Density in the Spine of Young Adult Rats: A Pilot Study - Ann Nutr Metab. 2009 Jun 9;54(3):218-226 - "These findings indicate that severe zinc deficiency initiated during adolescence may have important implications for future bone health, especially with regards to bone consolidation in the spine"

Neat Tech Stuff :

• Does Microsoft's Bing have Google running scared? -  CNET News, 6/14/09 - "In a story headlined "Fear grips Google," the New York Post reports that the launch of Microsoft's Bing search engine has so upset Google co-founder Sergey Brin that he has top engineers working on "urgent upgrades" to Google's service" - See Bing.com.  I made a web page (click here) with both a Google and Bing search block of my website and did a search of "ginkgo" and the Google returned much better results.

Supplement Focus (Co-enzyme Q10):

News & Research:

• ubiquinol products at Amazon.com
• Coenzyme Q10 - The Natural Pharmacist
• Coenzyme Q10 for Energy and Heart Support - Dr. Murray (.pdf)
• Neurological Health—CoQ10 - natmedonline.com
• CoQ10 - Heart disease - natmedonline.com
• Coenzyme Q10 Summary - U. of Texas Alternative Medicine
• Coenzyme Q10 - U. of Texas Alternative Medicine
• There seems to be a lot of hype about the benefits of CoQ10. Can you separate out the hype and tell me if I really need this supplement? - Dr. Murray
• I am taking the drug Lipitor to lower my cholesterol. I have heard that I need to take CoQ10 to offset a side effect of the drug - Dr. Murray
• Coenzyme Q10 - thenutritionreporter.com
• CoQ10 Improves Endothelial Dysfunction in Statin-Treated Type 2 Diabetics - Medscape, 5/29/09 - "Study subjects were randomized to receive either 200 mg/day of oral CoQ10 or placebo for 12 weeks ... Our absolute improvement in FMD of 1% with CoQ10 supplementation may potentially translate to a 10-25% reduction in residual cardiovascular risk in these patients"
• Taking Statins? Five Ways to Boost Your Energy - ABC News, 4/14/09 - "It's a cruel irony that if statins make patients more lethargic, it could impair their ability to exercise or make dietary changes that would help them address their high cholesterol ... some studies have found that patients' energy levels increased while using CoQ10 and statins together ... Try pomegranate juice or a small chunk of dark chocolate, both of which have beneficial antioxidants ... Skimping on sleep has been found to increase calcium deposit build-up in your arteries"
• Statin study: Lower cholesterol, diminished joy of sex linked - USA Today, 3/5/09 - "In the study, sexual pleasure sank along with LDL levels ... Some studies have found that statins improve sexual function, probably because the pills can improve blood flow to the genital area, Golomb says. But she says the drugs also may reduce Coenzyme Q10, a nutrient that helps cells convert oxygen, blood and glucose into energy. "Orgasm is a high-energy activity," so losing the nutrient could weaken sexual pleasure, she says" - See ubiquinol products at Amazon.com.
• Statins' Adverse Effects Documented - Science Daily, 1/29/09 - "Coenzyme Q10 ("Q10") is a compound central to the process of making energy within mitochondria and quenching free radicals. However, statins lower Q10 levels because they work by blocking the pathway involved in cholesterol production – the same pathway by which Q10 is produced. Statins also reduce the blood cholesterol that transports Q10 and other fat-soluble antioxidants ... "The loss of Q10 leads to loss of cell energy and increased free radicals which, in turn, can further damage mitochondrial DNA," said Golomb, who explained that loss of Q10 may lead to a greater likelihood of symptoms arising from statins in patients with existing mitochondrial damage – since these people especially rely on ample Q10 to help bypass this damage" - My favorite is QH-Absorb by Jarrow.
• Reduced CoQ10 shows superior bioavailability: SGTI study - Nutra USA, 1/21/09
• Product Review: CoQ10 and Ubiquinol Supplements - consumerlab.com, 1/13/09
• Wrinkle creams: Your guide to younger looking skin - CNN - "Coenzyme Q10 is a nutrient that helps regulate energy production in cells. Some studies have shown reduction in fine wrinkles around the eyes with no side effects"
• CoQ10 bioavailability boost from soft gels: Study - Nutra USA, 1/12/09 - "Researchers from Canada’s KGK Synergize compared CoQ10 formulations from hard and soft gel capsules, and found the reduced form from the latter resulted in a 3.3-fold higher blood level of CoQ10 than the former ... formulated by Soft Gel Technologies" - See iHerb search of "Soft Gel Technologies".  I'm sticking with QH-Absorb by Jarrow because I don't trust the NOW brand.  I feel that it probably just hasn't been studied yet.
• Coenzyme Q-10 Depletion Linked to Worse Heart Failure Outcomes - Medscape, 10/22/08 - "Low plasma concentration of coenzyme Q-10 is an independent predictor of reduced survival in patients with chronic heart failure"
• New Health Drink? Chemist Goes Nano With CoQ10 - Science Daily, 7/24/08
• CoQ10 may cut muscle injuries for athletes - Nutra USA, 5/5/08 - "The volunteers had daily training sessions of five and a half hours per day for six days during the intervention period. At day three and five of the six day training period, the researchers report that both groups experienced increased in serum creatine kinase activity and the concentration of myoglobin, but these increases were significantly lower in the group receiving the CoQ10 supplements ... Elevated levels of the enzyme are indicative of muscle damage and injury ... levels of lipid peroxide, a marker of oxidative stress, were also lower in the CoQ10 group after three and five days of training" - [Abstract]
• Migraine Patients May Benefit From Magnesium or CoQ10 - Clinical Psychiatry News, 8/07 - "The most important supplement, according to Dr. Mauskop, is magnesium. “It's known that up to 50% of people with acute migraine have a magnesium deficiency. … It is much more effective to treat them with a product they're deficient in rather than using drugs,” ... Research has found that, for migraine, CoQ10 at 300 mg/day is effective, and that for Parkinson's disease 1,200 mg/day is effective"
• Report: Has Your Coq10 Become Obsolete? - Life Extension Magazine, 1/07 - "scientists have demonstrated that the ubiquinol form of CoQ10 provides anti-aging effects that are far superior to those associated with the conventional ubiquinone form used by millions of Americans each day" - See ubiquinol products at Amazon.com.
• Novel Form Of Coq10 - Life Extension Magazine, 12/06
• Coenzyme Q10 review - ConsumerLab.com, 10/16/06
• More support for CoQ10’s benefits for heart health - Nutra USA, 9/12/06 - "the heart's functional capacity improved significantly by nine per cent, as measured by the peak volume of oxygen consumed (VO2), for the CoQ10 compared to placebo"
• Report: Coq10'S New Benefits - Life Extension Magazine, 8/06
• CoQ10 may protect against Alzheimer’s - Nutra USA, 4/24/06
• Coenzyme Q10 for Migraine Prophylaxis - Clinical Psychiatry News, 3/06 - "150 mg of coenzyme Q10 each day ... The study's primary outcome measure was the percentage of patients who achieved a greater than 50% reduction in the number of days with migraine. A total of 61.3% of patients met that outcome measure by 3 months, and 93.5% had at least a 25% reduction"
• CoQ10’s “Other” Health Benefits - Life Extension Magazine, 2/06 - "The latest findings suggest that, along with its heart-protective effects, CoQ10 may slow or improve some degenerative diseases, support cancer remission, counteract the toxic effects of chemotherapy, and decrease the incidence of migraine headaches. Additionally, recent findings indicate that coenzyme Q10 may have applications in promoting fertility, protecting auditory function, supporting longevity, boosting learning capability, sustaining muscle health and much more"
• Coenzyme Q10 New Applications for Cancer Therapy - Life Extension Magazine, 10/05
• Four powerhouse nutrients - Functional Foods and Nutraceuticals, 4/05 - "L-carnitine shuttles fuel into cells to be burned as energy; coenzyme Q10 sparks the energy within the cells; ribose is a component of adenosine triphosphate (ATP); and alpha-lipoic acid increases ATP levels"
• Coenzyme Q10 Lessens Muscle-Related Side Effects in Patients on Statins - Doctor's Guide, 3/7/05 - "Patients with significant myopathy who are taking statin therapy have a significant decrease in myopathic pain after 30 days of supplementation with coenzyme Q10" - See iHerb or Vitacost coenzyme Q10 products.
• The high five for hypertension - Functional Foods & Nutraceuticals, 12/04 - "Co-enzyme Q10 ... Omega-3 fatty acids ... Garlic ... L-arginine ... Calcium"
• Innovative Research and Applications for CoQ10 - Life Extension Magazine, 8/04 - "biomedical researchers are discovering that CoQ10 shows promising effects against disorders as far-ranging as kidney failure, heart disease, muscular dystrophy, and macular degeneration"
• Proprietary CoQ10 formulation demonstrates superior absorption - Nutra USA, 6/30/04
• Atorvastatin Reduces Blood CoQ10 Levels - Medscape, 6/22/04 - "Even brief exposure to atorvastatin causes a marked decrease in blood CoQ10 concentration ... Widespread inhibition of CoQ10 synthesis could explain the most commonly reported adverse effects of statins, especially exercise intolerance, myalgia, and myoglobinuria"
• Coenzyme Q10 May Ward Off Migraine Attacks - Medscape, 4/29/04 - "migraine may be caused by a decrease in mitochondrial energy reserve ... 100 mg of CoQ10 three times a day ... Approximately 48% of those who took CoQ10 had a 50% response rate during the three-month study, while this occurred in about 14% of those taking a placebo"
• Coenzyme Q10 & Fertility - Physician's Weekly, 4/5/04
• Cardiologists Overlook Lifesaving Discovery - Life Extension Magazine, 2/04
• Coenzyme Q10 May Play Positive Role in Treatment of Male Infertility - Medscape, 1/30/04 - "Patients underwent oral administration of CoQ10, 200 mg/day twice daily for six months ... After treatment, CoQ10 levels increased in seminal plasma; the mean value rising significantly from 42.0 +/- 5.1 ng/mL at baseline to 127.1 +/- 1.9 ng/mL after six months of CoQ10 administration"
• Coenzyme Q10 review - ConsumerLab.com, 1/13/03 - "There was no detectable CoQ10 in one product, another had only 71% of its claimed amount, and a third exceeded its claimed amount by 75%"
• Coenzyme Q10 Helps Sperm Movement - WebMD, 1/12/04 - "Researchers say coenzyme Q10 is known to be active in the testes and is an antioxidant that plays an important role in forming the membranes and other structures within cells by fighting the effects of oxidative stress ... researchers looked at the effects of daily oral supplementation with 200 mg of coenzyme Q10"
• Reason for concern? - Wellness Insider, 11/25/03 - "Dr. Golomb feels the potential side effects of statins, which include liver dysfunction, muscle pain (rhabdomyolysis), and potentially, muscle breakdown, have been significantly downplayed. She also feels that statins, especially at higher doses, contribute to memory loss and to the depletion of coenzyme Q10, a naturally occurring antioxidant-like nutrient vital to the production of energy"
• Water Soluble Form of Coenzyme Q10 Suggested for Migraine Prophylaxis - Doctor's Guide, 9/30/03 - "researchers used a new water-soluble form of coenzyme Q10 at 100 mg three times daily for migraine prophylaxis ... Of the Q10 group, 47.6% of the patients had a 50% response for attack frequency, compared to 14.3% for the placebo group, resulting in a therapeutic gain of about 33.3%"
• Coenzyme Q10 Beneficial for People with Kidney Failure - New Hope Natural Media, 7/17/03
• Guarding Your Gums? - Dr. Weil, 6/16/03 - "Periodontal disease is a chronic gum infection caused by bacteria in plaque ... Coenzyme Q10: Take 120 mg per day of a soft-gel form with meals ... young women who get less than 800 mg of calcium a day have double the risk of periodontal disease" - See iHerbor Vitacost"At least two randomized trials of the effects of coenzyme Q10 (another antioxidant) on blood pressure have been reported. In the first,[20] 59 treated hypertensives were randomized to either coenzyme Q10 (60 mg twice daily) or vitamin B (placebo); after 8 weeks, clinic blood pressure was 14/7 mm Hg lower in the treated group. In the second,[21] 83 patients with isolated systolic hypertension were treated with coenzyme Q10 (using the same dose as the earlier study) for 12 weeks. The mean reduction of blood pressure was 17.8/7.3 mm Hg"
• Coenzyme Q10 Deficiency Associated with Genetic Coordination Disorder - New Hope Natural Media, 6/12/03
• How To Prevent Breast Cancer Anti-Cancer Power of Coenzyme Q10 - Life Extension Magazine, 1/96
• Coenzyme Q10 Improves High Blood Pressure - New Hope Natural Media, 1/9/03 - "recruited 83 people with a condition called isolated systolic hypertension (ISH), in which the higher blood pressure ... These people were assigned to take either 60 mg of CoQ10 twice daily or a placebo for 12 weeks ... The people taking CoQ10 had an 18-point (18 mm Hg) reduction in systolic blood pressure (from 165 to 147 mm Hg), compared with only a 2-point decline in the placebo group ... ISH is the most common type of high blood pressure in the United States"
• The First Therapy Shown To Slow Progression of Parkinson's Disease - Life Extension Magazine, 1/03
• Coenzyme Q10 Appears To Slow Parkinson's Disease Progression - Doctor's Guide, 11/6/02
• Study Suggests Coenzyme Q10 Slows Functional Decline In Parkinson's Disease - Doctor's Guide, 10/15/02
• Coenzyme Q10 May Slow Parkinson's - WebMD, 10/14/02 - "High doses of the popular supplement coenzyme Q10 helps slow the progression of Parkinson's disease in some patients by as much as half ... Their study, published in the Oct. 15 issue of Archives of Neurology, is the latest to examine the possible benefits of coenzyme Q10, a vitamin-like compound naturally produced in the body and used by cells to make energy and protect against cellular damage"
• MEDLINE Abstracts: Antioxidants and the Aging Brain - Medscape, 9/27/02 - "Combinations of antioxidants might be of even greater potential benefit for AD, especially if the agents worked in different cellular compartments or had complementary activity (e.g. vitamins E, C and ubiquinone). Naturally-occurring compounds with antioxidant capacity are available and widely marketed (e.g. vitamin C, ubiquinone, lipoic acid, beta-carotene, creatine, melatonin, curcumin) and synthetic compounds are under development by industry" - Again, a broad spectrum of anti-oxidants, not just one or two.
• CoQ10, the Wonder Nutrient - Vitacost, 9/6/02 - "It was found that the concentrations of CoQ10 were significantly decreased in both plasma and whole blood of asthmatic sufferers compared with that of the healthy volunteers. The researchers speculated that sub-optimal concentrations of CoQ10 may play a possible contribution in patients with asthma"
• Dr. Julian M. Whitaker Petitions FDA to Include CoQ10 Use Recommendation in All Statin Drug Labeling - Life Extension Magazine, 8/02 - "On May 23, 2002, Dr. Julian M. Whitaker filed two citizens petitions with the Food and Drug Administration. The petitions call on the Commissioner of Food and Drugs to change the labeling of all HMG CoA reductase inhibitor drugs (the so-called statin drugs), and to issue a Medication Guide, warning consumers of the need to take coenzyme Q10 (CoQ10) whenever they take a statin drug"
• Coenzyme Q10 Effective for Migraine Prevention - New Hope Natural Media, 7/18/02 - "In the new study, 31 migraine sufferers were given 150 mg of CoQ10 per day for three months. The average number of days per month on which participants experienced headaches was 60% lower during the last two months of CoQ10 treatment than during the month prior to treatment. In addition, the average number of migraine attacks per month decreased by 42% with CoQ10 ... Two other nutrients that play a role in intracellular energy production (magnesium and riboflavin) have also been shown to reduce the recurrence rate of migraines"
• How CoQ10 Protects Brain Cells - Life Extension Magazine, 10/01 - "Newly published research suggests that CoQ10 can protect brain cells from neurotoxicity and excitotoxicity, while even powerful antioxidants cannot. CoQ10 proved highly effective, while simple antioxidants were ineffective, in protecting PC-12 cells (neuron-like rat adrenal cells commonly used in neurobiological research) from the excitotoxic effects of glutamate and from the Parkinson’s disease-like effects of the neurotoxin MPP+. L-deprenyl (the drug selegilene) also proved effective, though not as effective as CoQ10"
• ACSM Conference Unveils Performance Enhancers - Nutrition Science News, 9/01 - "Researchers have found that coenzyme Q10 (Co-Q10 or ubiquinone) can lower blood pressure in hypertensive people"
• CoQ10 Shows Promise In Slowing Progression Of Huntington's Disease - Intelihealth, 8/23/01
• Coenzyme Q10 Improves Cardiac Function in Children with Dilated Cardiomyopathy - Doctor's Guide, 5/30/01
• Bioenergetic Therapy for Aging - Life Extension Magazine, 2/01
• Staying Young Forever, Putting new research findings into practice - Life Extension Foundation, 12/99
• Patients With Hereditary Ataxia Show Improvement With CoQ10 (Ubiquinone) - Doctor's Guide, 4/10/01
• Trial of Coenzyme Q10 in Isolated Systolic Hypertension - Medscape, South Med J 94(11):1112-1117, 2001 - "The mechanisms underlying essential hypertension remain uncertain. A causal role for insulin resistance has been suggested,[35] and high levels of plasma insulin have frequently been found in patients with high blood pressure"
• How CoQ10 Protects Your Cardiovascular System - Life Extension Magazine, 4/00
• Drugs That Deplete- Nutrients That Heal - Life Extension Magazine, 7/00 - "A large number of drugs deplete Coenzyme Q10. These include such widely used tricyclic antidepressants as Elavil (amitriptyline) and Tofranil (imipramine), the anti-psychotic drug Haloperidol, cholesterol-lowering statin drugs such as Lovastatin and Pravastatin, beta-blockers, anti-diabetic sulfonylurea drugs such as Glucotrol (glipizide) and Micronase (glyburide), and the anti-hypertension drug Clonidine."
• Cellular Nutrition for Vitality and Longevity - Life Extension Magazine, 4/00
• How CoQ10 Protects Your Cardiovascular System - Life Extension Magazine, 4/00
• Staying Young Forever, Putting new research findings into practice - Life Extension Foundation, 12/99
• Nutrient Depletion Checklist - Nutrition Science News, 8/99
• Co-Q10 Energizes the Heart and Brain - Nutrition Science News, 7/99
• Co-Q10 and Cancer - Nutrition Science News, 4/99

Abstracts:

• Coenzyme Q(10) An Independent Predictor of Mortality in Chronic Heart Failure - J Am Coll Cardiol. 2008 Oct 28;52(18):1435-1441 - "Plasma CoQ(10) concentration was an independent predictor of mortality in this cohort. The CoQ(10) deficiency might be detrimental to the long-term prognosis of CHF, and there is a rationale for controlled intervention studies with CoQ(10)"
• Reducing exercise-induced muscular injury in kendo athletes with supplementation of coenzyme Q10 - Br J Nutr. 2008 Feb 20;:1-7 - "Subjects in the CoQ10 group took 300 mg CoQ10 per d for 20 d ... These results indicate that CoQ10 supplementation reduced exercise-induced muscular injury in athletes"
• Effect of Coenzyme Q(10), Riboflavin and Niacin on Tamoxifen treated postmenopausal breast cancer women with special reference to blood chemistry profiles - Breast Cancer Res Treat. 2008 Apr 22 - "Tamoxifen (TAM) ... TAM also has estrogenic activity on liver and endometrium causing severe oxidative stress with various biochemical derangements. Coenzyme Q(10), Riboflavin and Niacin (CoRN) are well-known potent antioxidants and protective agents against many diseases including cancer ... A statistically significant alteration in various blood chemistry parameters, such as serum total bilirubin (S. BIL), serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), gamma glutamyl transpeptidase (gamma-GT), uric acid (UA), lipoprotein lipase (LPL), lecithin: cholesterol acyl transferases (LCAT), potassium, calcium and Na(+), K(+)-ATPase in sole TAM-treated group, was favorably reverted back to near normal levels on combinatorial therapy with CoRN"
• Reducing exercise-induced muscular injury in kendo athletes with supplementation of coenzyme Q10 - Br J Nutr. 2008 Feb 20;:1-7 - "These results indicate that CoQ10 supplementation reduced exercise-induced muscular injury in athletes"
• Effect of Co-enzyme Q10 and Alpha-Lipoic Acid on Response of Rabbit Urinary Bladder to Repetitive Stimulation and In Vitro Ischemia - Urology. 2008 Feb 15 - "CoQ10 showed no protective effect. alpha-LA resulted in increased contractile responses of the control bladder and showed a moderate protective effect for all forms of stimulation. The combination, however, showed a significantly greater increase in the contraction of the control bladder and a greater protective effect than alpha-LA alone"
• Effects of CoQ10 supplementation on plasma lipoprotein lipid, CoQ10 and liver and muscle enzyme levels in hypercholesterolemic patients treated with atorvastatin: A randomized double-blind study - Atherosclerosis. 2007 Aug 4 - "All patients showed definite reductions of plasma CoQ10 levels in the placebo group, by 42%. All patients supplemented with CoQ10 showed striking increases in plasma CoQ10 by 127%. In conclusion atorvastatin definitely decreased plasma CoQ10 levels and supplementation with CoQ10 increased their levels"
• Effect of coenzyme Q10 administration on endothelial function and extracellular superoxide dismutase in patients with ischaemic heart disease: a double-blind, randomized controlled study - Eur Heart J. 2007 Jul 19 - "endothelium-dependent (ED) vasodilation ... improvements elicited by CoQ(10) supplementation were remarkable in subjects presenting low initial endothelium-bound ecSOD and thus more prone to oxidative stress ... The enhancement of peak VO(2) and of O(2) pulse is likely due to the bioenergetic effect of CoQ(10); on the other end, the improved VO(2) could also depend on the observed enhanced peripheral endothelial function"
• Coenzyme Q(10) in the treatment of hypertension: a meta-analysis of the clinical trials - J Hum Hypertens. 2007 Feb 8 - "We conclude that coenzyme Q(10) has the potential in hypertensive patients to lower systolic blood pressure by up to 17 mm Hg and diastolic blood pressure by up to 10 mm Hg without significant side effects"
• Effect of coenzyme q10 on myopathic symptoms in patients treated with statins - Am J Cardiol. 2007 May 15;99(10):1409-12 - "coenzyme Q10 supplementation may decrease muscle pain associated with statin treatment. Thus, coenzyme Q10 supplementation may offer an alternative to stopping treatment with these vital drugs"
• Coenzyme Q10 in the treatment of hypertension: a meta-analysis of the clinical trials - J Hum Hypertens. 2007 Apr;21(4):297-306 - "coenzyme Q10 has the potential in hypertensive patients to lower systolic blood pressure by up to 17 mm Hg and diastolic blood pressure by up to 10 mm Hg without significant side effects" - See ubiquinol at Amazon.com.
• Coenzyme Q10 and exercise training in chronic heart failure - Eur Heart J. 2006 Aug 1 - "CoQ10 main effect was: peak VO2+9%, EDDBA +38%, systolic wall thickening score index (SWTI) - 12%"
• Myocardial dysfunction in mitochondrial diabetes treated with Coenzyme Q10 - Diabetes Res Clin Pract. 2006 Apr;72(1):100-3 - "In our patient, after the introduction of Coenzyme Q10 150 mg/day, there was a gradual improvement on left ventricular function evaluated by echocardiography. The fractional shortening (FS) and ejection fraction (EF) increased from 26 to 34% and from 49 to 64%, respectively. No side effects were noted. Three months after CoQ10 discontinuation, the parameters of systolic function evaluated by echocardiography decreased, suggesting that CoQ10 had a beneficial effect"
• Clinical aspects of coenzyme Q10: an update - Curr Opin Clin Nutr Metab Care. 2005 Nov;8(6):641-6 - "A 4-year follow-up on 10 Friedreich's Ataxia patients treated with coenzyme Q10 and vitamin E showed a substantial improvement in cardiac and skeletal muscle bioenergetics and heart function"
• Atorvastatin Decreases the Coenzyme Q10 Level in the Blood of Patients at Risk for Cardiovascular Disease and Stroke - Arch Neurol. 2004;61:889-892 - "Even brief exposure to atorvastatin causes a marked decrease in blood CoQ10 concentration. Widespread inhibition of CoQ10 synthesis could explain the most commonly reported adverse effects of statins, especially exercise intolerance, myalgia, and myoglobinuria"
• Combined effect of coenzyme Q(10) and fenofibrate on forearm microcirculatory function in type 2 diabetes - Atherosclerosis 2003 May;168(1):169-79 - "CoQ did not change plasma isoprostanes, but significantly lowered systolic blood pressure and HbA(1c)"
• Effects of Coenzyme Q10 in Early Parkinson Disease: Evidence of Slowing of the Functional Decline - Archives of Neurology, 10/02 - "Less disability developed in subjects assigned to coenzyme Q10 than in those assigned to placebo, and the benefit was greatest in subjects receiving the highest dosage"
• Randomized, double-blind placebo-controlled trial of coenzyme Q10 in patients with acute myocardial infarction - Cardiovasc Drugs Ther. 1998 Sep;12(4):347-53
• Progress on therapy of breast cancer with vitamin Q10 and the regression of metastases - Biochem Biophys Res Commun 1995 Jul 6;212(1):172-7 - "The numerous metastases in the liver of a 44-year-old patient "disappeared," and no signs of metastases were found elsewhere. A 49-year-old patient, on a dosage of 390 mg of vitamin Q10, revealed no signs of tumor in the pleural cavity after six months, and her condition was excellent. A 75-year-old patient with carcinoma in one breast, after lumpectomy and 390 mg of CoQ10, showed no cancer in the tumor bed or metastases"
• Randomized, double-blind, placebo-controlled trial of coenzyme Q10 in isolated systolic hypertension - South Med J 2001 Nov;94(11):1112-7 - "conducted a 12-week randomized, double-blind, placebo-controlled trial with twice daily administration of 60 mg of oral CoQ ... The mean reduction in systolic blood pressure of the CoQ-treated group was 17.8"
• Effect of hydrosoluble coenzyme Q10 on blood pressures and insulin resistance in hypertensive patients with coronary artery disease - J Hum Hypertens. 1999 Mar;13(3):203-8 - "the following indices were reduced in the coenzyme Q10 group: systolic and diastolic blood pressure, fasting and 2-h plasma insulin, glucose, triglycerides, lipid peroxides, malondialdehyde and diene conjugates. The following indices were increased: HDL-cholesterol, vitamins A, C, E and beta-carotene ... treatment with coenzyme Q10 decreases blood pressure possibly by decreasing oxidative stress and insulin response in patients with known hypertension receiving conventional antihypertensive drugs"
• Partial and complete regression of breast cancer in patients in relation to dosage of coenzyme Q10 -  Biochem Biophys Res Commun 1994 Mar 30;199(3):1504-8 - "Six of the 32 patients showed partial tumor regression. In one of these 6 cases, the dosage of CoQ10 was increased to 390 mg. In one month, the tumor was no longer palpable and in another month, mammography confirmed the absence of tumor. Encouraged, another case having a verified breast tumor, after non-radical surgery and with verified residual tumor in the tumor bed was then treated with 300 mg. CoQ10. After 3 months, the patient was in excellent clinical condition and there was no residual tumor tissue"

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