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Anti-aging Research > Red Yeast Rice.
Red Yeast Rice
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News & Research:
-
Probiotic, Red Yeast
Rice Extract Combo May Cut Cholesterol - Medscape, 5/5/17 -
"Supplementation with the probiotic Bifidobacterium
longum BB536 added to red yeast rice extract improves lipid profiles in
patients with moderate hypercholesterolemia ... A 26% reduction in LDL was
what was we had in WOSCOPS on pravastatin 40 mg. So it's a very reasonable
reduction ... Overall, compliance was excellent at 97% and no adverse
effects were reported" - See
red yeast rice at Amazon.com
and
probiotic products at Amazon.com.
-
Phytosterols, Red Yeast
Rice, and Lifestyle Change vs Statin - Medscape, 8/13/13 -
"All participants took RYR and had significant
decreases in LDL-C, total cholesterol, triglycerides, high-sensitivity
C-reactive protein, and an increase in high-density lipoprotein cholesterol
for 1 year when compared with baseline"
-
Active ingredient levels vary among red yeast rice supplements - Science
Daily, 10/25/10 - "Across the 12 products, levels of
total monacolins ranged from 0.31 milligrams to 11.15 milligrams per capsule
and levels of monacolin K or lovastatin ranged from 0.10 milligrams to 10.09
milligrams per capsule. Four of the formulations had elevated levels of
citrinin"
-
Red Yeast Rice Comparable to Pravastatin for Statin-Intolerant Patients
- Medscape, 1/21/10 - "After 12 weeks of treatment,
red yeast rice reduced LDL-cholesterol levels 30% from baseline, from 181
mg/dL to 126 mg/dL, while pravastatin reduced LDL-cholesterol levels 27%, a
nonstatistical difference between treatments. Similarly, there were no
significant differences observed in changes in total cholesterol,
triglycerides, or HDL-cholesterol levels ... Regarding the primary end
point, the incidence of treatment discontinuation because of myalgia, both
red yeast rice and pravastatin were equivalent. In the red-yeast-rice arm,
one patient of 21 (5%) withdrew because of muscle pain, while two patients
of 22 (9%) withdrew in the pravastatin arm. Also, there were no reported
differences in the mean pain severity scores with the two treatments"
-
Statins Can Protect Against Alzheimer’s Disease, According To New Study
- Science Daily, 6/22/09 - "They clearly
demonstrated that treatment with a statin called Lovastatin could prevent
the death of nerve cells under these conditions. The statins not only
prevented cells from dying but also prevented the loss of memory capacity
that normally occurs after such cell death. In a previous study Dolga had
showed that these statins stimulate the protective capacity of tumor
necrosis factor, which is a key player in the brain’s immune response"
- [Abstract] -
Note: Lovastatin is in red yeast rice.
-
Red Yeast Rice May Lower Cholesterol - WebMD, 6/17/09 -
"After six months, patients who took the red yeast
rice had lowered their LDL cholesterol by an average of 35 mg/dL, compared
to 15 mg/dL among the placebo group"
-
Supplement may be statin alternative for some - CNN, 6/16/09 -
"Now a new study suggests that an over-the-counter
dietary supplement sold at pharmacies and health-food stores may be a
workable alternative for people who have statin-related muscle pain. It
seems that when combined with diet and lifestyle changes, red yeast rice
supplements can lower LDL, or bad cholesterol, levels by more than 20
percent without a substantial risk of muscle pain (also known as myalgia),
according to a study published Monday in the Annals of Internal Medicine"
- [Medscape]
-
Red Rice Yeast for Cholesterol Control? - Dr. Weil, 1/22/09 -
"Of all the natural supplements available to help
lower cholesterol, red rice yeast extracts are by far the most effective"
-
Fish Oil, Red Yeast Rice Cut Cholesterol - WebMD, 7/23/08 -
"We followed them for a three-month period ... The
LDL declined 42% in the supplement group and 39% in the Zocor group ... The
supplement group also lost an average of 10 pounds in 12 weeks, but there
was no significant weight loss in the medication group. Triglyceride levels,
while on average normal in both groups at the start, decreased by 29% in the
supplement group but just 9.3% in the medication group -- a significant
difference" - See
red yeast rice at Amazon.com
and
Mega Twin EPA at Amazon.com.
-
Lowering Blood Cholesterol With Fish Oil And Red Yeast Rice Instead Of
Statins - Science Daily, 7/8/08 - "The
alternative treatment group participants received daily fish oil and red
yeast rice supplements ... The statin group participants received 40
milligrams (mg) of Zocor (simvastatin) daily ... The researchers noted that
there was a reduction in LDL cholesterol levels in both groups. The
alternative treatment group experienced a 42.4 percent reduction, and the
statin group experienced a 39.6 percent reduction. Members of the
alternative therapy group also had a substantial reduction in triglycerides,
another form of fat found in the blood, and lost more weight" - See
red yeast rice at Amazon.com
and
Mega Twin EPA at Amazon.com.
- Red yeast
extract reduces major coronary events in large, randomized clinical trial
- theheart.org, 6/12/08
-
Chinese Red Yeast Rice Is Good For Your Heart, Study Suggests - Science
Daily, 6/9/08 - "a partially purified extract of
Chinese red yeast rice, Xuezhikang (XZK), reduced the risk of repeat heart
attacks by 45%, revascularization (bypass surgery/angioplasty),
cardiovascular mortality and total mortality by one-third and cancer
mortality by two-thirds"
- Controlling
Cholesterol? - Dr. Weil, 3/16/07 - "Of all the
natural supplements available to help lower cholesterol, red rice yeast
extracts are by far the most effective"
- Are Statins the New
Wonder Drugs? - Dr. Weil, 6/21/04 -
"For moderately elevated cholesterol, I recommend
non-prescription red rice yeast, a natural source of statins with fewer side
effects" - See
red yeast rice at Amazon.com.
-
Cholesterol-Lowering Supplements (Guggulsterones, Policosanol, Sterols)
review - ConsumerLab.com, 8/1/03
-
Controlling Cholesterol Naturally - Natural Foods Merchandiser, 8/03 -
"When you take the recommended amount of red yeast
rice, which is 1,200 mg a day [divided into two doses], it is equivalent to
taking 5 mg of a statin drug"
- Cholesterol
Drugs May Prevent Cancer - WebMD, 6/2/03 -
"Overall, taking
statins reduces risk of developing cancer by
20%, but that protection increases to 36% for people who take statins for
four years or more ... But the benefit stops about six months after the
patient stops taking the drug" - Note:
Red yeast rice is a non-prescription statin. See
red yeast rice at Amazon.com.
-
Statins Appear To Have Favourable Impact On Psychological Conditions
- Doctor's Guide, 4/2/03 - "the longer people are on
the
statins the more their symptoms of
depression, anxiety and hostility decrease
... When people stop taking statins or can not tolerate the medicine, their
depression, anxiety and hostility returns to pre-statin levels" -
Note: Red yeast rice is a non-prescription
statin but you should still check with your physician.
- Chinese Cholesterol
Control? - Dr. Weil, 10/1/02 - "And it contains
seven different statins, not just lovastatin.
In my experience, the natural mixture of compounds is less toxic (to the
liver and muscles) than isolated lovastatin ... Other brands of red rice
yeast extract are still available in the U.S., although they haven’t been
clinically proven as was Cholestin, and may not be as effective"
-
Dr. Julian M. Whitaker Petitions FDA to Include CoQ10 Use Recommendation in
All Statin Drug Labeling - Life Extension Magazine, 8/02 -
"On May 23, 2002, Dr. Julian M. Whitaker filed two
citizens petitions with the Food and Drug Administration. The petitions call
on the Commissioner of Food and Drugs to change the labeling of all HMG CoA
reductase inhibitor drugs (the so-called statin
drugs), and to issue a Medication Guide, warning consumers of the need
to take
coenzyme Q10 (CoQ10) whenever they take a statin drug" - I stuck
this in because red yeast rice is a non-prescription statin. - Ben
-
Statins May Help Prevent Alzheimer's Disease - Doctor's Guide, 4/16/02
- Statin Drugs May
Fight Alzheimer's, Too - WebMD, 4/9/02 - "Statins
block the vasoconstrictive [blood-vessel narrowing] effect of the A-beta
protein -- a critical protein involved in
Alzheimer's disease ... These drugs appear to have
anti-inflammatory properties, independent of their benefit in lowering
cholesterol, that may help protect against dementia" - Note:
Red yeast rice is a non-prescription statin.
- Possible red yeast rice alternative:
A Natural Anti-Cholesterol Dietary Supplement, Policosanol - Life
Extension Magazine, 6/01 - "policosanol lowered LDL
cholesterol 20% in 6 to 12 weeks at 10 mg/day. Total cholesterol was reduced
15%, and HDL increased 7%-28%. Taking 20 mg/day reduced LDL about 28%, total
cholesterol about 20%, and elevated HDL 7%-10%"
- Lovastatin Holds Promise
For Treatment In Head And Neck, Cervical Cancers
- Doctor's Guide, 11/1/01 - "five of 20 patients who
were administered lovastatin after other therapies failed to control their
disease were able to achieve long-term stable disease"
- Note: Lavostatin is the active ingredient in red yeast rice.
- Evaluation of
the Antihyperlipidemic Properties of Dietary Supplements
- Medscape, 4/1/01
-
Statins May Reduce Dementia Risk By 70 Percent - Doctor's Guide,
11/10/00 - "People over the age of 50 who are
prescribed cholesterol-lowering drugs known as statins may reduce by 70
percent their risk of developing dementia."
- Court
Rules FDA Can Regulate Supplement Marketed for Cholesterol
- WebMD, 7/26/03 - "The court then ordered the FDA
to lift its ban on the importation of red yeast rice, from which Cholestin's
active ingredient is derived ... This is not a natural form of red yeast
rice, it is a product modified to achieve the same benefits"
-
Studies: Chemical in some Chinese cuisine can lower cholesterol - CNN,
3/25/99 - "Levels of high-density lipoprotein
cholesterol (HDL), or "good" cholesterol, increased by 15 percent. Levels of
low-density lipoprotein cholesterol (LDL), or "bad" cholesterol, decreased
by 21 percent."
- Court Reverses FDA
Decision to Ban Import of Red Yeast Rice Product Cholestin™
- Herb World News Online, 6/17/98
Abstracts:
-
Red yeast rice dietary
intervention reduces oxidative stress-related inflammation and improves
intestinal microbiota - Food Funct 2022 May 27 -
"Inflammation and oxidative stress play key roles in the aging process, while
red yeast rice (RYR), a traditional Chinese fermented food, has anti-oxidant and
anti-inflammatory effects. To understand the anti-aging function of RYR in vivo,
this study established a D-galactose-induced aging mouse model to verify the
positive effects of RYR dietary intervention on aging and explore the related
underlying mechanism. Eight weeks of RYR dietary intervention was shown to have
a significant inhibitory effect on cognitive decline and hippocampal damage. The
molecular mechanistic studies showed that the anti-aging effects of RYR were
achieved by (i) improving the oxidative stress-related damage (increasing SOD,
CAT, and GSH, and reducing MDA), (ii) regulating the NF-κB inflammation pathway
induced by oxidative stress (decreasing the pro-inflammatory cytokines IL-6,
TNF-α, IFN-γ, iNOs, and IL-1β, increasing the anti-inflammatory cytokine IL-10,
and decreasing the expression of the NF-κB protein), (iii) slowing down
apoptosis caused by oxidative stress (reducing the expression of P21 and P53),
(iv) restoring the abundance of Lactobacillus, Lachnospiraceae and Rikenellaceae
downregulated by D-galactose, and (v) reducing the abundance of Akkermansia and
Helicobacter enriched by D-galactose" - See
red yeast rice at Amazon.com.
-
Statins
may provide protection against depression - Science Daily, 5/17/22 -
"Participants taking statins were less likely to
recognize fearful or angry faces and more likely to report them as positive,
indicating they had reduced negative emotional bias ... taking a statin
medication was associated with significantly lower levels of negative emotional
bias when interpreting facial expressions; this was not seen with other
medications, such as blood pressure medications ... It remains unclear exactly
how statins could protect against mental illness, but one possibility is that
they may work through anti-inflammatory mechanisms, which have also been
implicated in depression"
-
Decreased Risk of Stroke in
People Using Red Yeast Rice Prescriptions (LipoCol Forte®): a Total
Population-Based Retrospective Cohort Study - Evid Based Complement Alternat
Med 2022 Apr 23 - "Compared with the non-RYR cohort,
patients who received RYR prescriptions had a decreased risk of stroke (HR 0.65,
95% CI 0.59-0.71), including hemorrhagic stroke (HR 0.60, 95% CI 0.44-0.83),
ischemic stroke (HR 0.49, 95% CI 0.43-0.57), and other types of strokes (HR
0.53, 95% CI 0.42-0.67). The association between RYR prescription and stroke
risk was significant in both sexes and in people aged more than 40 years, as
well as in those individuals with various medical conditions. The frequency of
RYR prescription (HR 0.57, 95% CI 0.50-0.64) was associated with a decreased
risk of stroke with a dose-response relationship (p for trend<0.0001). This
study showed a potentially positive effect of RYR on the risk of stroke.
However, compliance with medication use should be cautioned" - See
red yeast rice at Amazon.com.
-
Red Yeast Rice for
Hypercholesterolemia: JACC Focus Seminar - J Am Coll Cardiol 2021 Feb 9 -
"The extracts of red yeast rice (RYR) are currently the
most effective cholesterol-lowering nutraceuticals. This activity is mainly due
to monacolin K, a weak reversible inhibitor of
3-hydroxy-3-methyl-glutaryl-coenzyme A reductase, whose daily consumption causes
a reduction in low-density lipoprotein (LDL)-cholesterol plasma levels up to 15%
to 25% within 6 to 8 weeks. The decrease in LDL-cholesterol is accompanied by a
proportional decrease in total and non-high-density lipoprotein cholesterol,
plasma apolipoprotein B, and high-sensitivity C-reactive protein. Some trials
suggest that RYR use is associated with improvement in endothelial function and
arterial stiffness, whereas a long-term study supports its role in the
prevention of cardiovascular events. Despite the statin-like mechanism of
action, the risk related to 3 to 10 mg monacolin K taken per day is minimal
(mild myalgia in previously severely statin-intolerant subjects). RYR could
represent a therapeutic tool to support lifestyle improvement in managing mild
to moderate hypercholesterolemia in low-risk patients, including those who
cannot be treated with statins or other LDL-cholesterol-lowering therapies"
-
Differential effects of
red yeast rice, Berberis aristata and Morus alba extracts on PCSK9 and LDL
uptake - Nutr Metab Cardiovasc Dis. 2019 Jun 14 - "The novel nutraceutical
combination containing red yeast rice (monacolin K 3.3 mg), Berberis aristata
cortex extract (Berberine 531.25 mg) and Morus alba leaves extract
(1-deoxynojirimycin 4 mg) is effective in the management of elevated plasma
low-density lipoprotein cholesterol (LDL-C) levels ... LDL receptor (LDLR)
expression ... B. aristata cortex extract (BCE), red yeast rice (RYR) and M.
alba leaves extract (MLE) ... The positive effect of MLE on PCSK9 supports the
rationale of using the nutraceutical combination of RYR, BCE and MLE to control
hyperlipidemic conditions" - See
red yeast rice at Amazon.com,
berberine at Amazon.com
and
Morus alba at Amazon.com.
-
Middle-Term Dietary Supplementation with Red Yeast Rice Plus Coenzyme Q10
Improves Lipid Pattern, Endothelial Reactivity and Arterial Stiffness in
Moderately Hypercholesterolemic Subjects - Ann Nutr Metab. 2016 Apr 8 -
"The long-term assumption of the tested dietary
supplement is associated with an improvement in LDL-cholesterolemia,
endothelial reactivity and PWV in moderately hypercholesterolemic subjects"
- See
Ubiquinol products at Amazon.com
and
red yeast rice at Amazon.com.
-
Mediterranean Diet and Red Yeast Rice Supplementation for the Management of
Hyperlipidemia in Statin-Intolerant Patients with or without Type 2 Diabetes
- Evid Based Complement Alternat Med. 2013;2013:743473 -
"for 24 weeks ... We studied 171 patients: 46 type 2 diabetic patients treated
with MD alone (Group 1), 44 type 2 diabetic patients treated with MD associated
with RYR (Group 2), 38 dyslipidemic patients treated with MD alone (Group 3),
and 43 dyslipidemic patients treated with MD plus RYR (Group 4). The mean
percentage changes in LDL cholesterol from the baseline were -7.34 ± 3.14% (P <
0.05) for Group 1; -21.02 ± 1.63% (P < 0.001) for Group 2; -12.47 ± 1.75% (P <
0.001) for Group 3; and -22 ± 2.19% (P < 0.001) for Group 4 with significant
intergroup difference (Group 1 versus Group 2, P < 0.001; Group 3 versus Group
4, P > 0.05). No significant increase in AST, ALT, and CPK levels was observed
in all groups. Our results indicate that MD alone is effective in reducing LDL
cholesterol levels in statin-intolerant patients with a presumably low
cardiovascular risk, but associating MD with the administration of RYR improves
patients' LDL cholesterol levels more, and in patients with type 2 diabetes"
- See
red yeast rice at Amazon.com.
| type 2 diabetic patients treated with MD alone (Group 1) |
-7.34 |
| type 2 diabetic patients treated with MD
associated with RYR (Group 2) |
-21.02 |
| dyslipidemic patients treated with MD alone (Group 3) |
-12.47 |
| dyslipidemic patients treated with MD plus RYR (Group 4) |
-22.00 |
-
Phytosterols, red yeast rice, and lifestyle changes instead of statins: A
randomized, double-blinded, placebo-controlled trial - Am Heart J. 2013
Jul;166(1):187-196.e2 - "lifestyle change (LC) ... red
yeast rice (RYR) ... A total of 187 participants (mean low-density lipoprotein
cholesterol [LDL-C], 154 mg/dL) took RYR 1800 mg twice daily and were randomized
to phytosterol tablets 900 mg twice daily or placebo. Participants were also
randomized to a 12-week LC program or usual care (UC) ... All participants took
RYR and had significant decreases in LDL-C, total cholesterol, triglycerides,
high-sensitivity C-reactive protein, and an increase in high-density lipoprotein
cholesterol for 1 year when compared with baseline ... The addition of
phytosterol tablets to RYR did not result in further lowering of LDL-C levels"
- See red yeast rice at Amazon.com.
-
A combined
natural supplement lowers LDL cholesterol in subjects with moderate untreated
hypercholesterolemia: a randomized placebo-controlled trial - Int J Food Sci
Nutr. 2013 Jul 2 -"To investigate the effect of a
natural cholesterol-lowering supplement (NCLS) containing red yeast rice,
policosanols and artichoke leaf extracts on blood lipid concentrations as well
as on safety parameters when given over 16 weeks in 100 volunteers with
untreated moderate hypercholesterolemia ... The NCLS was effective in reducing
low-density lipoprotein cholesterol and apolipoprotein B100 in subjects with
moderate hypercholesterolemia, without modifying safety parameters"
-
Long-term
effects of nutraceuticals (berberine, red yeast rice, policosanol) in elderly
hypercholesterolemic patients - Adv Ther. 2011 Nov 21 -
"containing berberine 500 mg, policosanol 10 mg, red
yeast rice 200 mg, folic acid 0.2 mg, coenzyme Q10 2.0 mg, and astaxanthin 0.5
mg) or placebo ... There was a statistically significant reduction in total
cholesterolemia (-20%), LDL-C (-31%), and insulin resistance (-10%) with
nutraceutical treatment. No significant changes were detected for plasma
high-density lipoprotein cholesterol (HDL-C). Furthermore, no statistical
differences were found between baseline and end-study safety parameters.
Medication compliance and tolerability were high" - Note: I’m been
promoting synergy and talking lower doses of everything proven in specific areas
like this for some time.
-
Lipid-Lowering Efficacy of Red Yeast Rice in a Population Intolerant to Statins
- Am J Cardiol. 2010 Mar 1;105(5):664-666 - "The total
cholesterol decreased 15% (-37 +/- 26 mg/dl, p <0.001) and LDL cholesterol
decreased 21% (-35 +/- 25 mg/dl, p <0.001) during 74 +/- 39 days of treatment.
Most (92%) patients tolerated the treatment, and many (56%) achieved their LDL
cholesterol goal. In patients unable to tolerate daily statin use, the total
cholesterol level decreased 13% (-33 +/- 10 mg/dl, p <0.001) and LDL cholesterol
decreased 19% (-31 +/- 4 mg/dl, p <0.001). In conclusion, red yeast rice
modestly decreased total and LDL cholesterol, was well-tolerated, and was an
acceptable alternative in patients intolerant of other lipid-lowering
medications"
-
Pretreatment with Lovastatin Prevents N-Methyl-D-Aspartate-Induced
Neurodegeneration in the Magnocellular Nucleus Basalis and Behavioral
Dysfunction - J Alzheimers Dis. 2009 Mar 6 -
"From these studies we conclude that treatment with lovastatin may provide
protection against neuronal injury in excitotoxic conditions associated with
neurodegenerative diseases including Alzheimer's disease" - Note:
Lovastatin (that's the
generic name and therefore shouldn't be capitalized) is in
red yeast rice. See
red yeast rice at Amazon.com.
-
An analysis of nine proprietary Chinese red yeast rice dietary supplements:
implications of variability in chemical profile and contents
- J Altern Complement Med 2001 Apr;7(2):133-9
-
Cholesterol-lowering effects of a proprietary Chinese red-yeast-rice dietary
supplement - Am J Clin Nutr. 1999 Feb;69(2):231-6
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