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Home > Health Conditions > Contraception.


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  • Vitamin B6 Supplementation Reduces Symptoms of Depression in College Women Taking Oral Contraceptives: A Randomized, Double-Blind Crossover Trial - J Diet Suppl 2022 Feb 2 - "Oral contraceptive (OC) users have a heightened risk of low plasma concentrations of vitamin B6, a cofactor in the tryptophan-serotonin pathway critical to mood regulation ... During the 12-week, randomized, double-blind crossover trial (4-week treatment periods [100 mg vitamin B6 daily or placebo] separated by a 4-week washout) participants (n = 8) maintained normal exercise and eating patterns and recorded tablet consumption daily. The Beck Depression Inventory-II (BDI-II) and Profile of Mood States (POMS) were used to assess mental health before and after each 4-week treatment period. Average dietary vitamin B6 intakes did not vary during the trial (1.2-1.4 mg/d), whereas vitamin B6 status rose significantly following the B6 supplementation period compared to the other three time points. BDI-II scores were reduced 20% by vitamin B6 supplementation in comparison to an 11% rise with placebo ingestion (p = 0.046). POMS scores were not significantly impacted by vitamin B6 supplementation. These preliminary data support a growing literature suggesting the benefits of B6 supplementation for reducing symptoms of depression in young women using OC" - See vitamin B6 at Amazon.com.
  • Supplementation with Vitamin B6 Reduces Side Effects in Cambodian Women Using Oral Contraception - Nutrients. 2014 Aug 26;6(9):3353-3362 - "1011 women obtaining oral contraception through the public health system in rural Cambodia were allocated to either intervention or control groups, receiving either daily Vitamin B6 supplement or care as usual (without placebo). Results: The intervention participants (n = 577) reported fewer side effects in three categories: nausea/no appetite, headache, and depression compared with control group participants (n = 434)"
  • Effect of contraceptive pill on the selenium and zinc status of healthy subjects - Contraception. 2009 Jul;80(1):40-3 - "Use of OCP resulted in a significant decrease in serum zinc levels (p</=.009, t=-3.666) and alteration of selenium levels but not significantly (p=.08, t=0.935)"
  • Trends Of Vitamin B6 Status In US Population Sample Identified - Science Daily, 5/20/08 - "Across the study population, we noticed participants with inadequate vitamin B6 status even though they reported consuming more than the Recommended Daily Allowance of vitamin B6, which is less than 2 milligrams per day ... Three quarters of the women who reported using oral contraceptives, but not vitamin B6 supplements, were vitamin B6 deficient"

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