Recent Longevity News for the seven days ending 3/25/09.  You should consult your doctor if you are taking any medications.

Fatty Fish May Cut Prostate Cancer Risk - WebMD, 3/24/09 - "Men in the study who ate one or more servings of fatty fish a week were found to have a 63% lower risk for developing aggressive prostate cancer than men who reported never eating fish" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.

Increasing Number Of Americans Have Insufficient Levels Of Vitamin D - Science Daily, 3/24/09 - "Average blood levels of vitamin D appear to have decreased in the United States between 1994 and 2004 ... Overall, the mean [average] serum 25(OH)D level in the U.S. population was 30 nanograms per milliliter during the 1988-1994 collection and decreased to 24 nanograms per milliliter during the 2001-2004 collection ... These findings have important implications for health disparities and public health" - See vitamin D at Amazon.com.

Diabetics On High-fiber Diets Might Need Extra Calcium - Science Daily, 3/24/09 - "Our new findings suggest that dietary fiber reduces the body's capacity to absorb calcium"

Heart Disease: Combined Treatment Is Best - WebMD, 3/23/09 - "Heart disease patients who achieve normal blood pressure and very low cholesterol levels with aggressive drug therapy do better than patients who achieve only one of these goals ... Patients who achieved LDL levels below 70 and systolic blood pressures of below 120 had the slowest progression, as measured by increase in plaque volume"

Vitamin D Supplements Associated With Reduced Fracture Risk in Older Adults - Doctor's Guide, 3/23/09 - "The authors then pooled the results of only the 9 trials in which participants received doses of more than 400 international units per day. At this dosage, vitamin D supplements reduced non-vertebral fractures by 20% and hip fractures by 18% ... A greater reduction in risk was also seen among trial participants whose blood levels of 25-hydroxyvitamin D achieved a greater increase" - [Science Daily] - See vitamin D at Amazon.com.

'Miracle Dog' Beats Aggressive Cancer - WebMD, 3/23/09 - "the drug is made of a cancer-killing substance called nitric oxide, which is attached to vitamin B12. Substances called receptors on a cell's surface attract the vitamin and help it enter the cell. Cancer cells grow abnormally fast with extra B12 receptors. NO-Cbl spots these receptors, sneaks into cancer cells, and releases the nitric oxide, which kills the cancer cells from within"

Tadalafil Response in Patients With Erectile Dysfunction Is Androgen Dependent - Doctor's Guide, 3/23/09 - "Testosterone gel therapy significantly improves the response to tadalafil in nonresponding patients with erectile dysfunction (ED) -- but only if they have total testosterone levels of less than 3 ng/mL or bioavailable testosterone levels of less than 0.6 ng/mL"

Eating Red, Processed Meat Associated With Increased Risk of Death From All Causes - Doctor's Guide, 3/23/09 - "When comparing the one-fifth of participants who ate the most white meat to the one-fifth who ate the least white meat, those with high white meat intake had a slightly lower risk for total death, death from cancer and death from causes other than heart disease or cancer ... For overall mortality, 11% of deaths in men and 16% of deaths in women could be prevented if people decreased their red meat consumption to the level of intake in the first quintile ... The impact on cardiovascular disease mortality was an 11% decrease in men and a 21% decrease in women if the red meat consumption was decreased to the amount consumed by individuals in the first quintile. For women eating processed meat at the first quintile level, the decrease in cardiovascular disease mortality was approximately 20%" - [Science Daily]

Really? - The Claim - Fish Oil Supplements Can Contain Mercury - NYTimes.com, 3/23/09 - "The concern is a common one, but studies have found that most of the widely available supplements contain little or no mercury, dioxins or PCBs. For one thing, most companies use species of fish that are lower on the food chain, like cod and sardines, which accumulate less mercury. And many companies distill their oils to help remove contaminants"

New Yogurt Fights Stomach Ulcers - WebMD, 3/22/09 - "H. pylori uses an enzyme called urease to attach to and infect the inside of the stomach. This latest yogurt, designed to fight stomach ulcers, contains an antibody called IgY-urease. The yogurt is marketed as Dr. Piro in Japan and as Gut in Korea. Researchers are hopeful that their clinical trial will pave the way for approval in the United States ... For the trial, scientists recruited 42 people who tested positive for H. pylori. Some participants ate the yogurt with the antibody three times a day for four weeks. Some participants ate the same amount of regular yogurt that didn't contain the antibody. H. pylori activity was significantly reduced in the antibody yogurt group"

Probiotics May Relieve Symptoms of Irritable Bowel Syndrome - Medscape, 3/20/09 - "In patients with IBS, probiotics showed a modest improvement in overall symptoms, using both dichotomous and continuous data"

Inadequate Vitamin D Levels Linked To High Use Of Narcotic Medication By Patients In Chronic Pain - Science Daily, 3/20/09 - "Mayo Clinic research shows a correlation between inadequate vitamin D levels and the amount of narcotic medication taken by patients who have chronic pain ... Physicians who care for patients with chronic, diffuse pain that seems musculoskeletal — and involves many areas of tenderness to palpation — should strongly consider checking a vitamin D level ... many patients who have been labeled with fibromyalgia are, in fact, suffering from symptomatic vitamin D inadequacy" - See vitamin D at Amazon.com.

Moderate Obesity Takes Years Off Life Expectancy - Science Daily, 3/19/09 - "moderate obesity, which is now common, reduces life expectancy by about 3 years, and that severe obesity, which is still uncommon, can shorten a person’s life by 10 years. This 10 year loss is equal to the effects of lifelong smoking"

Grape polyphenols may protect against obesity: Study - Nutra USA, 3/18/09 - "animals fed a high-fat diet but supplemented with the grape seed extract had adiponectin levels 61 per cent higher than animals only fed the high fat diet. Adiponectin is a protein hormone linked to various metabolic processes, and levels are inversely related to body fat levels" - [Abstract] - See grape seed extract at Amazon.com.

Abstracts from this week's Doctor's Guide Nutrition/Dietetics plus abstracts from my RSS feeds (Click here for the journals, the PubMed ones at the top):

Red blood cell membrane alpha-linolenic acid and the risk of sudden cardiac arrest - Metabolism. 2009 Apr;58(4):534-40 - "Higher levels of long-chain n-3 polyunsaturated fatty acids in red blood cell membranes are associated with lower risk of sudden cardiac arrest. Whether membrane levels of alpha-linolenic acid, a medium-chain n-3 polyunsaturated fatty acid, show a similar association is unclear ... Higher membrane alpha-linolenic acid was associated with a higher risk of sudden cardiac arrest: after adjustment for matching factors and smoking, diabetes, hypertension, education, physical activity, weight, height, and total fat intake, the odds ratios corresponding to increasing quartiles of alpha-linolenic acid were 1.7 (95% confidence interval [CI], 1.0-3.0), 1.9 (95% CI, 1.1-3.3), and 2.5 (95% CI, 1.3-4.8) compared with the lowest quartile. The association was independent of red blood cell levels of long-chain n-3 fatty acids, trans-fatty acids, and linoleic acid. Higher membrane levels of alpha-linolenic acid are associated with higher risk of sudden cardiac arrest" - Note:  Alpha-linolenic acid (a medium-chain n-3 polyunsaturated fatty acid) is the omega-3 found in vegetable sources such as flaxseed as opposed to the eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) forms (long-chain n-3 polyunsaturated fatty acids) found in fish oils.

The response of gamma vitamin E to varying dosages of alpha vitamin E plus vitamin C - Metabolism. 2009 Apr;58(4):469-78 - "vitamin E has several isomers, with the alpha form being available via dietary supplements and the gamma form being available via dietary foodstuffs. The gamma form of vitamin E demonstrates several superior properties (such as trapping reactive nitrogen species and detoxifying nitrogen dioxide) compared with alpha vitamin E. All clinical trials have used the alpha isomer, with little concern that this isomer of vitamin E may actually suppress the gamma isomer of vitamin E ... The results demonstrate that alpha vitamin E levels increased in proportion to the dose administered. However, at every dose of alpha vitamin E, gamma vitamin E concentration was significantly suppressed ... Our results suggest that all prospective cardiovascular clinical trials that used vitamin E supplementation actually suppressed the beneficial antioxidant gamma isomer of vitamin E" - Dah!!  I've been saying that for years.  They're finally catching on.  See Jarrow FamilE (contains all eight members of the vitamin E family, includes Tocomin) at Amazon.com.

Fruit and vegetable consumption and risk factors for cardiovascular disease - Metabolism. 2009 Apr;58(4):460-8 - "Consumption of fruits and vegetables is associated with lower concentrations of total and low-density lipoprotein cholesterol and with the risk of CVD per se in a dose-response manner"

Trans-10, cis-12-conjugated linoleic acid reduces the hepatic triacylglycerol content and the leptin mRNA level in adipose tissue in obese Zucker fa/fa rats - Br J Nutr. 2009 Mar 19:1-13 - "Conjugated linoleic acid (CLA) isomers have been reported to reduce body weight and beneficially affect glucose metabolism in animals, but the results are inconsistent and seem to depend on animal model and type of CLA isomer. In the present study, feeding male Zucker fa/fa rats diets supplemented with 1 % trans-10, cis-12-CLA for 10 d reduced the liver TAG content without improving the overall adiposity, and enhanced hepatic mitochondrial and peroxisomal beta-oxidation ... The present results suggest that dietary supplementation with trans-10, cis-12-CLA may increase the catabolism of lipids in liver and adipose tissue. Moreover, we provide new data suggesting that trans-10, cis-12-CLA modulates the expression of resistin and adiponectin inversely in adipose tissue. Hence, the present results suggest that trans-10, cis-12-CLA may have some beneficial effects on lipid metabolism and adiposity but possibly reduces insulin sensitivity" - See conjugated linoleic acid at Amazon.com.

Conjugated Linoleic Acid Supplementation Enhances Antihypertensive Effect of Ramipril in Chinese Patients With Obesity-Related Hypertension - Am J Hypertens. 2009 Mar 19 - "Participants were randomized to a daily dose of 4.5 g/day CLA (nine 0.5-g capsules; a 50:50 isomer blend of c 9,t 11 and t 10,c 12 CLA) with 37.5 mg/day ramipril (group 1) or placebo with 37.5 mg/day ramipril (group 2) for 8 weeks ... Treatment with CLA significantly enhanced the reduction effect of ramipril on systolic BP and diastolic BP (P < 0.05). It also increased plasma adiponectin concentration (P < 0.05) and decreased plasma concentrations of leptin and angiotensinogen (P < 0.05); however, significant change was not observed in ACE activity" - See conjugated linoleic acid at Amazon.com.

Gamma-linolenic acid inhibits both tumour cell cycle progression and angiogenesis in the orthotopic C6 glioma model through changes in VEGF, Flt1, ERK1/2, MMP2, cyclin D1, pRb, p53 and p27 protein expression - Lipids Health Dis. 2009 Mar 17;8(1):8 - "Gamma-linolenic acid is a known inhibitor of tumour cell proliferation and migration in both in vitro and in vivo conditions ... Combination therapy using drugs with other, complementary targets and GLA could lead to gains in treatment efficacy in this notoriously difficult to treat tumour" - See borage oil at Amazon.com.

Chardonnay grape seed procyanidin extract supplementation prevents high-fat diet-induced obesity in hamsters by improving adipokine imbalance and oxidative stress markers - Mol Nutr Food Res. 2008 Nov 26 - "GSE prevented in part these effects, reducing insulinemia and leptinemia by 16.5 and 45%, respectively, whereas adiponectin level increased by 61% compared with obese controls. GSE lowered glycemia and HOMA-IR and strongly prevented cardiac production of superoxide by 74% and NAD(P)H oxidase expression by 30%. This is the first time that chronic consumption of grape phenolics is shown to reduce obesity development and related metabolic pathways including adipokine secretion and oxidative stress" - See grape seed extract at Amazon.com.

Resveratrol Prevents the Prohypertrophic Effects of Oxidative Stress on LKB1 - Circulation. 2009 Mar 16 - "Our data identify a molecular mechanism in the cardiomyocyte involving the oxidative stress-derived lipid peroxidation byproduct HNE and the LKB1/AMPK signaling pathway that contributes to the development of left ventricular hypertrophy. We also suggest that resveratrol may be a potential therapy for patients at risk for developing pathological cardiac hypertrophy by preventing this prohypertrophic process" - See resveratrol products at Amazon.com.

Health Focus (chronic pain):

Related Topics:

• NSAIDS / migraines / arthritis / neuropathic pain / COX-2 inhibitors / Neurontin / Lamictal / substance P / acupuncture / magnetic therapy / chiropractic / fibromyalgia

Popular Supplements:

• Vitamin D / enzymes / Wobenzym / D,L-phenylalanine / tumeric / chondroitin / SAM-e / willow bark / cayenne / devil's claw / MSM

Alternative News:

• Pain (Chronic) - Life Extension Foundation
• MSM and DMSO - thenutritionreporter.com
• Inadequate Vitamin D Levels Linked To High Use Of Narcotic Medication By Patients In Chronic Pain - Science Daily, 3/20/09 - "Mayo Clinic research shows a correlation between inadequate vitamin D levels and the amount of narcotic medication taken by patients who have chronic pain ... Physicians who care for patients with chronic, diffuse pain that seems musculoskeletal — and involves many areas of tenderness to palpation — should strongly consider checking a vitamin D level ... many patients who have been labeled with fibromyalgia are, in fact, suffering from symptomatic vitamin D inadequacy" - See vitamin D at Amazon.com.
• Only Exercise Effective In Preventing Low-back Problems, Review Suggests - Science Daily, 3/1/09 - "Strong and consistent evidence finds many popular prevention methods to fail while exercise has a significant impact, both in terms of preventing symptoms and reducing back pain-related work loss"
• Study: Cymbalta May Cut Chronic Low Back Pain - WebMD, 8/26/08
• Pain 'linked with low vitamin D' - BBC News, 8/11/08 - "Low levels of the sunshine vitamin, vitamin D, may contribute to chronic pain among women ... If I had chronic pain I would certainly check I was getting enough vitamin D" - See vitamin D at Amazon.com.
• Associations Between Vitamin D Status and Pain in Older Adults: The Invecchiare in Chianti Study - J Am Geriatr Soc. 2008 Mar 5 - "Lower concentrations of 25(OH)D are associated with significant back pain in older women but not men. Because vitamin D deficiency and chronic pain are fairly prevalent in older adults, these findings suggest it may be worthwhile to query older adults about their pain and screen older women with significant back pain for vitamin D deficiency" - See vitamin D at Amazon.com.
• Vitamin D deficiency linked to greater pain - Nutra USA, 10/15/07 - "Of these patients, 26 per cent had vitamin D inadequacy and needed almost twice the dose of morphine of the group with adequate vitamin D levels" - See vitamin D at Amazon.com.
• More Than A Pill: Complementary Medicine Can Help With Chronic Pain - Science Daily, 10/9/07
• 5 fixes to help you stand up to back pain - CNN, 4/17/07
• Herbal Medicine May Be Effective for Low Back Pain - Medscape, 1/16/07 - "Short-term treatments with certain herbal medicines (including Devil's claw and willow bark) are effective for relief of acute low back pain" - See Devil's claw products and White willow bark products at iHerb.
• Antioxidants: New Kid On The Block For Pain Relief? - Science Daily, 11/8/06
• 3 Herbal Medicines May Ease Back Pain - WebMD, 4/18/06 - "A 60-milligram daily dose of devil's claw also appeared to cut back pain as much as a 12.5-milligram daily dose of Vioxx, a painkiller no longer on the market due to a rise in the risk of cardiovascular events -- such as heart attackheart attack and strokestroke -- in some patients"
• omega-3 Fatty acids (fish oil) as an anti-inflammatory: an alternative to nonsteroidal anti-inflammatory drugs for discogenic pain - Surg Neurol. 2006 Apr;65(4):326-31 - "were asked to take a total of 1200 mg per day of omega-3 EFAs (eicosapentaenoic acid and decosahexaenoic acid) found in fish oil supplements ... Our results mirror other controlled studies that compared ibuprofen and omega-3 EFAs demonstrating equivalent effect in reducing arthritic pain. omega-3 EFA fish oil supplements appear to be a safer alternative to NSAIDs for treatment of nonsurgical neck or back pain in this selective group" - See Mega Twin EPA at iHerb or Vitacost.
• Herbal Therapies to Relieve Pain: Efficacy and Adverse Effects - Medscape, 1/13/06
• High-Dose Omega-3 Oils Used to Treat Non-Surgical Neck and Back Pain - Doctor's Guide, 4/20/05 - "this could be the answer to the adverse effects seen with nonsteroidal anti-inflammatory drugs (NSAIDs), including cyclooxygenase (COX)-2 inhibitors, which have been associated with potentially catastrophic adverse effects ... 88% percent said they were pleased enough with the outcomes that they planned to continue using the fish oils" - See Mega Twin EPA at Amazon.com or Vitacost.
• Glucosamine Ups Ibuprofen's Pain Relief - WebMD, 1/9/04 - "While the NSAID administered alone had pain-relieving effects, glucosamine administered alone produced no pain-relieving effect ... But when glucosamine was combined with an NSAID, pain relief was more pronounced" - See ibuprofen at Amazon.com and iHerb or Vitacost glucosamine products.
• Lack of Vitamin D Linked to Pain - WebMD, 12/10/03
• People with Undetermined Muscle/Bone Pain May be Vitamin D Deficient - Doctor's Guide, 12/10/03 - "Research conducted at the University of Minnesota found that 93 percent of all subjects with non-specific musculoskeletal pain were vitamin D deficient"
• Vitamin D Effective Treatment for Chronic Low Back Pain - New Hope Natural Media, 5/1/03 - "new study in Spine (2003;28:177–9) ... All participants with vitamin D deficiency reported improvement in their back pain after taking vitamin D, whereas 69% of those with normal vitamin D levels improved"
• B-Vitamins Prove Effective In Relieving Chronic Pain - Intelihealth, 4/10/03 - "B-vitamins, such as thiamin (B1), pyridoxine (B6), and cyanocobalamin (B12), have been proven to be clinically effective in treating various painful conditions such as lumbago, sciatica, trigeminal neuralgia, facial paralysis and optic neuritis as acting as an analgesia (pain reliever)"
• Magnet Therapy Effective for Chronic Pelvic Pain - New Hope Natural Media, 3/28/03 - "The authors point out that successful treatment depends on using magnets with proper intensity and polarity. In the studies that showed no benefit with magnets, the intensity of the magnets used was too weak to have any meaningful effect on the body"
• Soothing Sciatica? - Dr. Weil, 7/23/02
• Soy Fights Pain - WebMD, 3/15/02
• Willow Bark Cheap Alternative To Pain Killers For Low Back Pain - Intelihealth, 1/31/02 - "Noting that willow bark is roughly 40% less expensive than rofecoxib [Vioxx], the researchers conclude that willow bark and rofecoxib are equally safe and effective in the treatment of low back pain, but that willow bark extract "has the current advantage of being cheaper than rofecoxib.""
• Can Laughter Relieve Pain And Help Us Heal? Researchers Seek An Answer - Intelihealth, 9/5/01
• Enzymes Can Hasten Pain Relief - Nutrition Science News, 2/01 - "Enzymes work not by stopping or blocking inflammation, but by supporting and quickening the process . . . By the third day after the operation, levels of C-reactive protein—a measure of inflammation—were threefold higher in the control group"
• The Chemistry of Pain - Nutrition Science News, 2/01
• Natural COX-2 Inhibitors: The Future of Pain Relief - Nutrition Science News, 8/00
• Persistent Pain - Nutrition Science News, 10/99
• Chronic Joint Pain - Nutrition Science News, 1/99

CME:

• Medscape pain CME courses
• Doctor's Guide back pain CME courses
• The Cost of Pain - PowerPak.com, exp. 5/30/05

General Information:

• Pain - American Academy of Family Physicians
• Pain - emedicine.com
• Pain - FamilyDoctor.org
• Managing Chronic Pain - Physician's Weekly, 10/25/04
• Prescription Drugs and Pain Medications - WebMD, 10/13/03
• Chronic Pain - Veritas Medicine
• Treatments for chronic pain - Medifocus.com

Other News:

• Aching Back? Cholesterol Medication Might Help - Science Daily, 3/3/09 - "A new study finds that using statins may be useful in treatment for degenerative discA new study finds that using statins may be useful in treatment for degenerative disc ... Lovastatin increased the synthesis of collagen II, a protein that makes up moveable joints, and decreased the synthesis of collagen I, a protein that is related to fibrosis (the formation or development of excess fibrous connective tissue)" - Note:  Lovastatin is the one that red yeast rice is high in.
• Motor Control Exercises Reduce Persistent Low-back Pain, Study Shows - Science Daily, 1/28/09
• New Minimally Invasive Back Surgery Shows Promising Results, Physicians Report - Science Daily, 1/2/08
• Acute Back Pain: Spine Therapy No Help - WebMD, 11/7/07
• ACP And APS Issue Comprehensive Guidelines For Treating Low-back Pain - Science Daily, 10/1/07
• Low Back Pain: Many Options for Relief - WebMD, 10/1/07
• New Shoulder Pain Treatment Is Effective, Study Suggests - Science Daily, 9/24/07
• Two Fixes for Bad Backs - Time Magazine, 6/21/07
• The best new pain cures, with a focus on women - CNN, 6/21/07
• Back Surgery Better For Spinal Stenosis And Slipped Vertebra, According to Second SPORT Study - Science Daily, 5/30/07
• New Treatment Offers Relief From Chronic Back Pain - Science Daily, 5/18/07
• New Procedure Allows Diagnosis Of Lower Back Pain Cause - Science Daily, 5/4/07
• Morphine Makes Lasting -- And Surprising -- Change In The Brain - Science Daily, 4/24/07
• Alpharma Receives FDA Approval for Kadian(R) (Morphine Sulfate) 80mg Capsules - Doctor's Guide, 10/31/06
• FDA OKs New Cancer Pain Drug - WebMD, 9/27/06
• Cephalon Receives Approvable Letter for Fentora(TM) (fentanyl buccal tablet) for Management of Breakthrough Pain in Patients with Cancer - Doctor's Guide, 6/30/06
• Penwest Announces That Endo Reports Receiving Final FDA Approval for Oxymorphone ER - Pain Relief Product Expected to Be Commercially Available in the U.S. in the Coming Weeks Under Trade Name Opana(R) ER - Doctor's Guide, 6/23/06
• Synera, a New Topical Anesthetic Patch Developed by ZARS Pharma, is Launched - Doctor's Guide, 6/20/06
• ALZA Corporation Receives FDA Approval for Ionsys (Fentanyl Iontophoretic Transdermal System) - Doctor's Guide, 5/23/06
• Some Anti-Depressants Ease Pain as Well as Opioids, Review Shows - Doctor's Guide, 5/23/06
• Once Daily Ultram ER Extended-Release Tablets Now Available in the United States - Doctor's Guide, 2/21/06
• Comorbid Addiction and Chronic Pain - Clinical Psychiatry News, 10/05
• Biovail's Tramadol ER Receives FDA Approval - Doctor's Guide, 9/9/05
• New Research Suggests Oxycodone May be More Effective Than Morphine in Treatment of Visceral Pain - Doctor's Guide, 8/25/05
• Surgery No Better Than Rehabilitation For Low Back Pain - Doctor's Guide, 5/23/05
• FDA Issues Approval Letter For Tramadol ODT, for Moderate to Severe Pain - Doctor's Guide, 5/6/05
• Pregabalin Cuts Pain in Tough-To-Treat Patients With Neuropathic Pain and Fibromyalgia Syndrome - Doctor's Guide, 4/13/05
• FDA Approves New Pain Reliever - WebMD, 1/3/05
• FDA Approves New Drug for Severe Pain - WebMD, 12/29/04
• FDA Approves Prialt (Ziconotide Intrathecal Infusion) for Severe Chronic Pain - Doctor's Guide, 12/29/04
• FDA approves new drug for severe pain - MSNBC, 12/28/04
• Single-Shot Epidural DepoDur (Morphine Sulfate Extended-Release Liposome Injection) Now Available in US - Doctor's Guide, 12/6/04
• FDA Approves Combunox (Oxycodone HCl and Ibuprofen) Tablets for Short-Term Treatment Of Acute, Moderate to Severe Pain - Doctor's Guide, 11/29/04
• Chronic Back Pain May Shrink the Brain - WebMD, 11/22/04
• Low-Dose Oxymorphone Effective for Pain Relief - Doctor's Guide, 10/19/04
• Kadian (Morphine Sulfate) Pain Medication Safe, Effective for the Elderly - Doctor's Guide, 3/5/04
• Issues in Perioperative Pain Management - Physician's Weekly, 1/19/04
• Anti-Epileptic Drug Levetiracetam May Relieve Pain With Minimal Side Effects - Doctor's Guide, 12/30/03
• New Treatment Guide Provides Simplified, Diagnostic Approach To Acute Low Back Pain Treatment - Doctor's Guide, 10/22/03
• The Face of Untreated Pain - Physician's Weekly, 10/20/03
• Warding Off Ulcers Due to Painkillers - WebMD, 10/15/03
• FDA Approves Darvocet A500 (Propoxyphene Napsylate And Acetaminophen) For Mild To Moderate Pain - Doctor's Guide, 9/11/03
• Amitriptyline Supplementation Offers Added Benefit to Corticosteroid Injections in Patients with Low Back Pain - Doctor's Guide, 9/10/03
• New Data Confirms Expanded Role for Fentanyl Transdermal System in Treatment of Osteoarthritis, Rheumatoid Arthritis and Lower Back Pain - Doctor's Guide, 9/4/03
• Available Treatment Options for Pain in Elderly Cancer Patients - Doctor's Guide, 9/3/03
• New Oxycodone/Acetaminophen Dosage Effective in Low Back Pain Treatment - Doctor's Guide, 8/14/03
• New Formulation Of Actiq (Oral Transmucosal Fentanyl Citrate) Approved By FDA - Doctor's Guide, 8/7/03
• Lidocaine 5% Patch Safe, Effective for Low Back Pain - Doctor's Guide, 7/4/03
• Intradiscal Injection Has Potential In Treatment Of Low Back Pain - Doctor's Guide, 7/4/03
• Conversion From Transdermal To Intravenous Fentanyl Safely, Effectively Treats Acute Cancer Pain - Doctor's Guide, 7/3/03
• MRI Shows People Feel Pain Differently - WebMD, 6/23/03
• Radiographs as Good as MRI for Most Patients With Low Back Pain - Medscape, 6/3/03
• Spinal Manipulation Better Than Sham Therapies for Low Back Pain - Medscape, 6/3/03
• Body Pain Linked to Higher Cancer Rates - WebMD, 6/2/03
• Aceclofenac More Tolerable, Similar Efficacy to Diclofenac for Acute Back Pain - Doctor's Guide, 6/2/03
• Resistance Training Best for Neck Pain - WebMD, 5/20/03
• Tramadol/Acetaminophen Effective in Elderly Patients with Chronic Back Pain - Doctor's Guide, 5/20/03
• Add Lidocaine Patch to Gabapentin for Pain Relief - Clinical Psychiatry News, 5/03
• Computed Tomography-Guided Interventional Procedures Promising In Treating Back Pain - Doctor's Guide, 5/6/03
• New Antidepressants Target Aches and Pains, Too - Psychiatric News, 4/18/03
• Lower Dose Flexeril (Cyclobenzaprine) Relieves Acute Painful Muscle Spasm With Less Sedation Than Higher Dose - Doctor's Guide, 4/14/03
• Opioid Use Suggested for Pain Management - Doctor's Guide, 4/7/03
• New Electrical Therapy May Relieve Low Back Pain - Clinical Psychiatry News, 4/03
• Painkillers Work Best on Redheads - WebMD, 3/28/03
• Oral Opioid Treatment Curbs Chronic Neuropathic Pain - Doctor's Guide, 3/27/03
• Chronic Pain: Opioids Effective for Nerve Pain - WebMD, 3/26/03
• Gabapentin Plus Valacyclovir Effective for Management of Acute Zoster Pain - Medscape, 3/25/03
• Lower Back Pain: New Treatments Coming Soon - WebMD, 3/24/03
• Continuous Heat Effectively Reduces Lower Back Pain - WebMD, 3/21/03
• Keppra (Levetiracetam) Helps Alleviate Pain, Reduce Narcotic Use In Cancer Patients - Doctor's Guide, 3/20/03
• Keppra (Levetriacetam) Relieves Pain From Variety Of Pain Syndromes - Doctor's Guide, 3/20/03
• Widely Used Questionnaire Spots Depression in Chronic Pain Patients - Doctor's Guide, 2/25/03
• Lidocaine Patch Enhances Chronic Pain Therapy - Doctor's Guide, 2/25/03
• Extended Release Morphine Formulations Improve Sleep in Osteoarthritis - Doctor's Guide, 2/25/03
• Constipation Appears Common in Chronic Pain Patients on Controlled-Release Oxycodone - Doctor's Guide, 2/21/03
• Chronic Painful Physical Conditions [CPPCs] Strongly Associated With Major Depression - Doctor's Guide, 2/19/03 - "A diagnosis of major depressive disorder was made in 4% of participants, and 43.4% of those with major depression had at least one CPPC. The researchers point out this was four times the rate in people without major depressive disorder"
• Bupivacaine With Epinephrine Relieves Children's Post-Surgical Pain - Doctor's Guide, 2/14/03
• FDA Approves Lower Dose Flexeril (Cyclobenzaprine) For Treatment Of Muscle Spasm - Doctor's Guide, 2/4/03
• Depression And Chronic Pain Linked, May Influence Diagnosis, Treatment - Doctor's Guide, 1/16/03 - "A new study finds that people who have major depression are more than twice as likely to have chronic pain when compared to people who have no symptoms of depression" - See substance P.
• Leave Spouse Alone During Back Pain - Intelihealth, 11/4/02
• Functional Improvement in Chronic Low Back Pain Seen With Etoricoxib Study - Doctor's Guide, 10/29/02
• Lower-Back and Fibromyalgia Pain Linked, Possible Source Identified - Doctor's Guide, 10/28/02
• 'No-Cause' Back Pain Really Hurts - WebMD, 10/28/02
• Preoperative Ketorolac More Effective Post-Operatively, Vioxx (Rofecoxib) More Effective After Patient Discharge - Doctor's Guide, 10/15/02
• Pamidronate May Help Improve Back Pain - Doctor's Guide, 10/14/02
• Opioids Should Be Considered For Relief Of Chronic Lower Back Pain - Doctor's Guide, 10/3/02
• Opioids Recommended for Back Pain - WebMD, 10/3/02
• Is Pain Misunderstood? - WebMD, 9/20/02
• Single Dose of Dexketoprofen Trometamol Effectively Controls Pain Associated with Renal Colic - Doctor's Guide, 8/23/02
• Buprenorphine Transdermal System Effective for Cancer/Non-Cancer Pain with Minimal Side Effects - Doctor's Guide, 8/23/02
• Oral Methadone Effective as First-line Opioid Treatment for Chronic Non-Cancer Pain - Doctor's Guide, 8/23/02
• Oral Contraceptives May Reduce Pain in Women with Temporomandibular Disorder - Doctor's Guide, 8/22/02
• Long-term Opioid Use for Non-Cancer Pain Not Associated with Cognitive Decline - Doctor's Guide, 8/22/02
• Long Term Use of Transdermal Fentanyl by Non-Cancer Pain Patients Does Not Impair Driving Ability - Doctor's Guide, 8/22/02
• Single Pre Surgery Dose of Parecoxib Followed by Valdecoxib for Seven Days Post Surgery Effective for Laparoscopic Cholescystectomy Pain - Doctor's Guide, 8/22/02
• Gabapentine Effective for Severe Back Pain and Restless Leg Syndrome Associated with Rapid Opioid Detoxification - Doctor's Guide, 8/21/02
• Lamotrigine Effective in Refractory Neuropathic Pain - Doctor's Guide, 8/21/02
• Patient Controlled Analgesia with IV Morphine Safe and Effective in Elderly Patients - Doctor's Guide, 8/21/02
• Acetylsalicylic Acid (ASA) Effective for Pain Associated with Common Cold - Doctor's Guide, 8/21/02
• Etoricoxib Superior to Oxycodone/Acetaminophen for Acute Pain - Doctor's Guide, 8/21/02
• Intrathecal Clonidine Effective for Treatment of Intractable Non-Malignant Pain - Doctor's Guide, 8/21/02
• Alvimopan is Well Tolerated and Effective for Reversal of Opioid-Induced Bowel Dysfunction - Doctor's Guide, 8/21/02
• Gabitril (Tiagabine) Demonstrates Efficacy as Augmenting Agent for Treatment of Chronic Pain with Comorbid Anxiety Disorders - Doctor's Guide, 8/21/02
• Subarachnoid Chromaffin Cell Allograft is Effective Analgesic in Patients with Terminal Cancer Pain - Doctor's Guide, 8/20/02
• Buprenorphine TDS Demonstrates Long Term Pain Relief and Good Tolerability in Cancer and Chronic Pain - Doctor's Guide, 8/20/02
• Novel Parenteral Opioid CJC-1008 Demonstrates Safety and Staying Power in Preliminary Studies - Doctor's Guide, 8/20/02
• Strontium 89 Offers Effective Pain Relief for Patients with Bony Metastases - Doctor's Guide, 8/16/02
• Shedding Light on Pain Management - Healthscout.com, 8/13/02
• Normal Activity Can Be As Good As Bed Rest In Acute Low Back Pain Patients - Doctor's Guide, 7/29/02
• Intrathecal Clonidine Effective, Tolerable in Long-Term Treatment of Pain - Doctor's Guide, 7/11/02
• Shock Wave Helps Tennis Elbow - WebMD, 7/3/02
• Cancer Pain Relief - WebMD, 5/29/02
• Low-Level Heat Wrap More Effective Than Oral Analgesics For Acute Low Back Pain - Doctor's Guide, 5/28/02
• Pioneering Durogesic (Transdermal Fenatyl) Skin Patch: A Clear Choice In Chronic Pain Which Is Difficult To Treat - Doctor's Guide, 5/27/02
• Heat Wraps Beat Low-Back Pain - WebMD, 5/22/02
• Implantable Drug Delivery Systems Improve Survival, Reduce Pain and Drug Toxicity in Cancer Patients with Refractory Pain - Doctor's Guide, 5/22/02
• Implantable Pain Pumps Improve Cancer Patients' Quality Of Life, May Increase Survival Rate - Doctor's Guide, 5/21/02
• Hands-on Approach Best for Neck Pain - WebMD, 5/20/02
• Electrothermal Therapy Significantly Reduces Chronic Low Back Pain - Doctor's Guide, 5/15/02
• New Guidelines for Pain Control in Older Patients - Medscape, 5/14/02
• 'Pain Relief Ball' Cuts Opioid Use After Gynecologic Surgery - Medscape, 5/9/02
• Study Finds New Pain Relief Treatment Cuts Morphine Use After Surgery By More Than 40 Percent In Women Undergoing Cesarean Sections - Doctor's Guide, 5/8/02
• Low-dose Morphine Does not Cause Neurological Injury in Preterm Infants - Doctor's Guide, 5/7/02
• Intradiscal Electrothermal Therapy Benefits Low Back Pain - Medscape, 5/6/02
• Heat Treatment Soothes Chronic Back Pain - WebMD, 5/1/02
• Easing Back Pain After Fracture - WebMD, 4/12/02
• Pain Perception By Older People Is Affected By Age, Sex And Cognitive Function - Doctor's Guide, 4/11/02
• Dexketoprofen May Improve Pain, Reduce Morphine Use After Hip Arthroplasty - Doctor's Guide, 4/3/02
• FDA Approves Once-Daily Avinza (Extended Release Morphine) For Chronic, Moderate-To-Severe Pain - Doctor's Guide, 3/21/02
• JCAHO Standard for Pain Scoring Lacks Power in ED - Doctor's Guide, 3/18/02
• Cancer Patients with Breakthrough Pain Prefer Actiq Treatment - Doctor's Guide, 3/18/02
• Chronic Low-Back Pain Responds to Etoricoxib - Doctor's Guide, 3/15/02
• Tramadol and Acetaminophen Combination Relieves Back Pain - Doctor's Guide, 3/15/02
• Actiq (Oral Transmucosal Fentanyl Citrate) Provides Option for Breakthrough Cancer Pain - Doctor's Guide, 3/15/02
• Study Suggests that Ultracet (tramadol/ acetaminophen) Provides Rapid Relief of Oral Surgery Pain - Doctor's Guide, 3/11/02
• Pethidine Should Be Used For Acute But Not Chronic Pain - Doctor's Guide, 3/6/02
• Managing Pain: What's Next, What Works - WebMD, 2/22/02
• The Pitfalls of Opioids for Chronic Nonmalignant Pain - Medscape, 2/02
• Bextra (Valdecoxib) Offers Effective, Morphine-Sparing Pain Relief After Knee Surgery - Doctor's Guide, 2/12/02
• New Drug Fights Osteoarthritis Flare-Ups - WebMD, 11/27/01
• FDA Approves New Percocet Strengths With Lower Acetaminophen Doses - Doctor's Guide, 11/26/01
• New Drug Relieves Troubling Side Effect of Cancer Painkillers - WebMD, 10/31/01
• Transdermal Administration of Fentanyl Effective in Postsurgical Pain - Doctor's Guide, 10/17/01
• FDA Approves Ultracet (Tramadol/Acetominophen) For Acute Pain - Doctor's Guide, 8/20/01
• Massage May Be Best Approach for Back Pain, Combination of Treatments Often Necessary - WebMD, 5/31/01
• Botulinum Toxin Injections May Ease Low Back Pain - Doctor's Guide, 5/22/01
• Botox could help back pain - CNN, 5/22/01
• Wonder-Poison Spells Relief for Low Back Pain, Researchers Find Yet Another Use for Botox - WebMD, 4/21/01
• Lidoderm (Lidocaine Patch) Relieves Post-Herpetic Neuralgia Pain - Doctor's Guide, 5/15/01
• Electrical Spine Stimulation Relieves Pain Even When Cause Is Unknown - WebMD, 4/26/01
• Once Daily Vioxx (Rofecoxib) Significantly Reduces Chronic Low Back Pain - Doctor's Guide, 4/23/01
• Two-Step Titration Helps Switch Cancer Pain Patients From Intravenous To Transdermal Fentanyl - Doctor's Guide, 4/22/01 - "Slowly switching cancer patients from intravenous to transdermal fentanyl in a two-step approach prevents pain crises"
• Rofecoxib Better Than Combination Acetaminophen/Codeine For Acute Pain Control - Doctor's Guide, 4/22/01 - "Rofecoxib [Vioxx] was superior to the narcotic combination in total pain relief over six hours, in peak pain relief, in the patient's own assessment of pain relief and in the time required to take rescue medication"
• Parecoxib Appears As Effective As Ketorolac, Morphine In Reducing Knee Surgery Pain - Doctor's Guide, 4/22/01 - "40 mg of intravenous parecoxib provides equivalent pain relief for up to 24 hours as did ketorolac, the only available intravenous (IV) non-steroidal anti-inflammatory drug ... In addition, parecoxib, an investigational cyclooxygenase (COX-2) inhibitor, was statistically significantly more effective in controlling pain than 4 mg of morphine, 20 mg of parecoxib and placebo"
• Lamotrigine Reduces Pain For Stroke Patients - Doctor's Guide, 1/23/01
• Health Focus:The Proper Use Of Analgesics - Intelihealth, 12/20/00
• Artificial discs offer new hope for bad backs - CNN, 12/18/00
• No Support in Study for Back Belts as Injury Preventers - WebMD, 12/6/00
• Study: Back belts don't prevent back injury - CNN, 12/5/00
• No Support in Study for Back Belts as Injury Preventers - WebMD, 12/5/00
• Study: Steroid Eases Shingles Pain - Intelihealth, 11/24/00
• New Treatment 'Impressive' for Pain Following Shingles - WebMD, 11/22/00
• Better Pain Management Needed To Speed Up Recovery Times And Decrease Stress - Doctor's Guide, 11/6/00
• Vioxx (Rofecoxib) Significantly Reduces Pain After Dental Surgery - Doctor's Guide, 11/3/00
• Chronic Pain Requires Special Attention In Children - Doctor's Guide, 11/3/00
• Cluster Headaches May Occur Without Pain - Doctor's Guide, 8/8/00
• Patients Encouraged To Work With Their Doctors To Reduce Arthritis Pain - Doctor's Guide, 4/6/00
• Higher Dose Of Duraclon (Clonidine) Now Available For Severe Neuropathic Pain - Doctor's Guide, 3/2/00
• Risk Of Addiction To Pain Relief Is Small, Expert Says - Doctor's Guide, 2/21/00
• Oral Fentanyl Offers Superior Management Of Breakthrough Cancer Pain - Doctor's Guide, 10/25/99
• Osteoarthritis Drug, Vioxx, Relieves Menstrual Pain - Doctor's Guide, 10/19/99
• Older, Disabled Women Have Trouble Managing Pain - Doctor's Guide, 6/15/99
• Actiq Now Available In The U.S. For Breakthrough Cancer Pain - Doctor's Guide, 3/31/99
• FDA Approves Actiq For Breakthrough Cancer Pain - Doctor's Guide, 11/5/98
• Quadramet Is Effective In Relieving Pain Of Spreading Cancer - Doctor's Guide, 3/30/98
• Back Pain Can Be A Long-Term Problem For Some Women - Doctor's Guide, 2/9/98
• High-Dose Caffeine May Be Effective Pain Reliever - Doctor's Guide, 11/7/97
• Many Americans With Chronic Pain Misdiagnosed - Doctor's Guide, 7/17/97
• Poor Communication A Barrier To Good Pain Management - Doctor's Guide, 7/17/97
• New Treatment Relieves Bone Pain Caused By Advanced Cancer - Doctor's Guide, 5/21/97
• Actiq Proven Effective For Breakthrough Pain In Cancer Patients - Doctor's Guide, 5/20/97
• Waterbase Pillow Effective For Reducing Neck Pain, Headaches - Doctor's Guide, 2/6/97
• Doctors' Good Intentions May Prolong Low Back Pain - Doctor's Guide, 11/15/96

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