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Cialis (tadalafil)

Tadalafil at reliablerxpharmacy.com

Related Topics:

• Viagra (sildenafil) / Uprima® (apomorphine) / Levitra (vardenafil) / Cialis (tadalafil) / Stendra (avanafil) / Alprox-TD (alprostadil) / Trimix (alprostadil plus papaverine plus phentolamine) / Zydena (udenafil) / impotence / testosterone / Melanotan / Bremelanotide

News & Research:

• Erectile Dysfunction Drug Tadalafil Exerts Modest Glucose Control - Medscape, 12/9/21 - "International Index of Erectile Function (IIEF-5) score and the International Prostate Symptom Score (IPSS) ... At the end of the study, A1c levels declined compared with baseline by an average of 0.137% in the tadalafil group and rose by an average of 0.196% in the placebo group ... After 6 months, average fasting plasma glucose was 6.40 mg/dL lower than baseline in the tadalafil group and was 5.35 mg/dL higher than baseline in the placebo group ... Improvement in the IIEF-5 score was significantly greater in the tadalafil group than in the placebo group at 6 months, with an average score of 6.56 with tadalafil and 2.22 with placebo ... The IPSS showed a numerical improvement among patients taking tadalafil compared with those taking placebo, which was not significant" - See tadalafil at ReliableRXPharmacy.
• An Open-Label, Single-Arm Pilot Study to Evaluate the Efficacy of Daily Low Dose Tadalafil on Depression in Patients With Erectile Dysfunction - Medscape, 12/11/19 - "Patient Health Questionnaire (PHQ)-9 ... Analyses of the mean changes in the PHQ-9 scores revealed that the depressive symptoms of the subjects were significantly improved after administration of eight weeks of tadalafil ... Serum levels of BDNF were higher after tadalafil treatment compared to before treatment; however, this difference was not statistically significant"
• Erectile dysfunction drug 'effective' as heart failure treatment - Science Daily, 5/1/19 - "The study of Tadalafil -- which is in the same class as Viagra -- proves that the drug is biologically effective as a treatment for heart failure in sheep ... When the animals had heart failure -- induced by pace makers -- which was sufficiently advanced to need treatment, the team administered the drug. Within a short period the progressive worsening of the heart failure was stopped and, importantly the drug reversed the effects of heart failure ... And the biological cause of breathlessness in heart failure- the inability of the heart to respond to adrenaline was almost completely reversed"
• Evaluation of arterial stiffness and cardiac function in patients with vascular erectile dysfunction: acute effects of phosphodiesterase-5 inhibitor tadalafil - Int J Impot Res. 2016 Dec 8 - "Treatment with tadalafil reduced pulse pressure (P=0.0179), systolic blood pressure (P=0.001) and diastolic blood pressure (P=0.054) and increased aortic distensibility (P=0.001) and aortic strain (P=0.003) in the ED group. Tadalafil administration also increased large artery and small artery elasticity indices that were reduced in the ED group at baseline (P=0.02 and 0.003, respectively)"
• Psychosocial Outcomes After Tadalafil or Sildenafil for ED: Conclusions - Medscape, 2/16/15 - "Patients initiating ED treatment with tadalafil OaD or tadalafil PRN reported greater improvement in Sexual Self-Confidence and Spontaneity (PAIRS) compared with patients starting with sildenafil PRN. Patients on sildenafil or tadalafil PRN treatment showed larger improvements in the IIEF sexual intercourse satisfaction domain, possibly due to a higher number of intercourse attempts. There were no significant treatment differences regarding improvement of IIEF-EF, orgasmic function, overall satisfaction domains, SEAR or EDITS in all three treatment groups. When initiating ED treatment, the different treatment options should be offered for participative decision-making, to optimize psychological benefit and treatment satisfaction for each patient"
• Tadalafil Approved for Benign Prostatic Hyperplasia - Medscape, 10/6/11 - "The US Food and Drug Administration (FDA) today approved tadalafil (Cialis, Eli Lilly), a phosphodiesterase-5 inhibitor, to also treat the signs and symptoms of benign prostatic hyperplasia (BPH) as well as a combination of BPH and erectile dysfunction (ED) when the conditions coincide ... Tadalafil joins a long list of other FDA-approved drugs for BPH symptoms: finasteride (Proscar), dutasteride (Avodart), dusasteride plus tamsulosin (Jalyn), and alpha-blockers terazosin (Hytrin), doxazosin (Cardura), tamsulosin (Flomax), alfuzosin (Uroxatral), and silodosin (Rapaflo)"
• Patients' preference in the treatment of erectile dysfunction: a critical review of the literature - Int J Impot Res. 2010 Dec 30 - "the majority of the patients preferred tadalafil versus either vardenafil or sildenafil"
• FDA Approves Tadalafil Tablets for Pulmonary Arterial Hypertension - Doctor's Guide, 5/26/09
• Tadalafil May Effectively Treat Symptoms Of BPH-LUTS In Addition To Erectile Dysfunction - Science Daily, 4/26/09 - "After 12 weeks of treatment, the men taking tadalafil experienced improved detrusor pressure at urinary flow rate, peak flow rate (Qmax), bladder capacity, post-void residual volume and bladder voiding efficiency. Relative symptom improvement in the IPSS also was significantly better in the tadalafil group" - See tadalafil at OffshoreRx1.com.
• Study: No Vision Loss From ED Drugs - WebMD, 4/13/09 - "researchers randomly assigned 244 healthy men age 30 to 65, some with mild erectile dysfunction, to take a daily dose of 5 milligrams of Cialis, 50 milligrams of Viagra, or a placebo for six months ... The results showed no significant differences between those who took the erectile dysfunction drugs or the placebo on ERG, vision function tests, pressure within the eyeball, or assessments of the anatomy of the eye"
• Tadalafil Response in Patients With Erectile Dysfunction Is Androgen Dependent - Doctor's Guide, 3/23/09 - "Testosterone gel therapy significantly improves the response to tadalafil in nonresponding patients with erectile dysfunction (ED) -- but only if they have total testosterone levels of less than 3 ng/mL or bioavailable testosterone levels of less than 0.6 ng/mL"
• Tadalafil Most Effective Treatment for Severe Erectile Dysfunction, Preferred by Patients - Doctor's Guide, 12/9/08 - "Tadalafil is slightly more effective than sildenafil and vardenafil in treating men with severe erectile dysfunction (ED), and more ED patients preferred tadalafil for erection quality, according to a prospective, randomised study presented at the Joint Congress of the European and International Societies for Sexual Medicine"
• Erectile Dysfunction Drug Shows Promise For Relief Of Lower Urinary Tract Symptoms Associated With Benign Prostate Disease - Science Daily, 8/19/08
• ED Drugs May Treat Urinary Problems - WebMD, 5/23/07 - "Sexual performance in men seems to decline as their prostate enlargement becomes more severe, experts have begun to notice ... A once-a-day dose of Cialis helped men with erectile dysfunction and moderate to severe urinary tract symptoms due to an enlarged prostate improve sexual functioning"
• Tadalafil May Be Helpful for Erectile Dysfunction in Men With Prostatic Carcinoma - Medscape, 10/5/06
• Cialis Improves Sexual Function For Prostate Cancer Survivors - Science Daily, 10/3/06
• Tadalafil Improves Sexual Function for Prostate Cancer Survivors - Doctor's Guide, 10/2/06
• Phosphodiesterase Type 5 (PDE5) Inhibitors in Erectile Dysfunction - Medscape, 8/24/06 - "29% (n = 85) of men chose to continue with sildenafil and 71% (n = 206) of men chose to continue with tadalafil (p < 0.001) for the 8-week extension phase"
• New Data Show Tadalafil Effective in Treating Erectile Dysfunction Caused by Traumatic Spinal Cord Injury - Doctor's Guide, 4/6/06
• In Recent Study, Canadian Men with Erectile Dysfunction and their Partners Prefer Cialis (Tadalafil) over Another Leading Treatment - Doctor's Guide, 12/5/05 - "Cialis® (tadalafil) was preferred over Viagra® (sildenafil)"
• Tadalafil Shows Benefits in Men on Antidepressants - Doctor's Guide, 10/21/04
• Tadalafil (Cialis) Can Significantly Improve Erections for Up to 36 Hours - Doctor's Guide, 6/23/04
• Cialis (Tadalafil) European Label Changed to Include Effectiveness up to 36 Hours - Doctor's Guide, 2/24/04
• Tadalifil Appears Safe in Patients Taking One or More Antihypertensive Drugs - Doctor's Guide, 12/12/03
• 'Le Weekend' Pill Newest Option for ED - HealthDay, 11/24/03
• Longer-Lasting Erection Drug Approved - WebMD, 11/21/03 - "Which one do men like best? In a recent head-to-head-to-head study of all three drugs taken at the recommended starting dose by men with erectile dysfunction: ... 47% preferred Levitra ... 34% preferred Viagra ... 19% preferred Cialis"
• FDA Approves 3rd Impotence Drug - HealthDay, 11/21/03
• Impotence Drugs Duke It Out - WebMD, 11/17/03
• Patients with Erectile Dysfunction Prefer Treatment with Levitra (Vardenafil HCl) - Doctor's Guide, 11/17/03 - "In terms of overall preference, most men rated vardenafil as the preferred option (47%) compared with tadalafil (19%) or sildenafil (34%) at the recommended starting dose. Vardenafil was also the preferred option at the maximum dose (43% compared to 40% taldalafil, 17% sildenafil)"
• Tadalafil Effective for Up to 36 Hours in Half of Patients With ED - Medscape, 7/11/03
• Two erectile dysfunction medications, touted to last longer, await FDA nod - HealthDay, 2/27/03 - "All three work by inhibiting an enzyme known as phosphodiesterase 5 (PDE-5) ... the big difference is how long they remain active in the bloodstream ... Cialis remains active for a full 24 hours, with 59 percent of men reporting effects for up to 36 hours. Levitra has a similar time profile"
• Cialis (Tadalafil), Treatment For Erectile Dysfunction, Now Available In Europe, New Zealand, And Australia - Doctor's Guide, 2/4/03
• Tadalafil, Vardenafil Target Erectile Dysfunction - Clinical Psychiatry News, 10/02
• Erectile Dysfunction Drug Tadalafil Appears Effective in Men with Mild to Moderate Disease - Doctor's Guide, 9/3/02
• Viagra: Are the Competitors Better? - Dr. Weil, 8/16/02
• Tadalafil Treats Erectile Dysfunction; Low Cardiovascular Risk - Medscape, 5/31/02
• New Impotence Drugs Nearing Approval - WebMD, 5/28/02
• New Erectile Drug [Cialis] Lasts Longer Than Viagra, Companies Say As Study Is Released - Intelihealth, 5/28/02
• Patients on Tadalafil See Relief of Erectile Dysfunction for 36 Hours - Doctor's Guide, 5/27/02
• New Erection Drugs on the Way - WebMD, 2/8/02
• Cialis (Tadalafil) Shows Consistent Effect in Men With Erectile Dysfunction - Doctor's Guide, 10/2/01
• FDA Asked to Approve Once-a-Day Erectile Dysfunction Drug - WebMD, 7/6/01
• CIALIS (IC351) Restores Natural Sexual Function For 24-Hour Period - Doctor's Guide, 6/25/01
• Investigative Drug, Cialis, Outperforms Placebo For Erectile Dysfunction - Doctor's Guide, 6/6/01
• Cialis (IC351) Provides Extended Period of Responsiveness In Men With Erectile Dysfunction - Doctor's Guide, 5/1/01
• Cialis (IC351) Improves Sexual Function In Diabetic Men With Erectile Dysfunction - Doctor's Guide, 4/6/01
• Investigational Drug, Cialis (IC351), May Improve Mild-To-Severe Erectile Dysfunction - Doctor's Guide, 3/19/01 - "improved erections in 81 percent of men (relative to placebo - 17 percent), regardless of severity ... up to 80 percent of patients with severe ED and up to 90 percent of patients with moderate ED reported significant improvement in their ability to attain and maintain an erection ... the only three treatment-related adverse events reported by greater than three percent of men were headache, back pain and dyspepsia (stomach upset following meals). These effects were generally mild to moderate and tended to decrease with time ... The condition is associated with a range of behavioural risk factors, such as cigarette smoking and excessive alcohol consumption, as well as numerous other medical conditions, notably diabetes and cardiovascular disease"
• Investigational Drug, Cialis (IC351), Reported To Improve Erections - Doctor's Guide, 11/28/00

Abstracts:

• Efficacy and Safety of Tadalafil vs Tamsulosin in Lower Urinary Tract Symptoms (LUTS) as a Result of Benign Prostate Hyperplasia (BPH)-open Label Randomised Controlled Study - Int J Clin Pract 2020 Jun 15;e13530 - "100 patients of BPH with an IPSS score of more than 7, without any complications of the disease were computer randomised to receive therapy with either tamsulosin 0.4 mg or tadalafil 5 mg once daily for a period of 2 months ... once daily monotherapy with tadalafil 5 mg or tamsulosin 0.4 mg was equally efficacious in the management of moderate to severely bothersome LUTS in majority of patients as a result of BPH. The role of Tadalafil monotherapy in BPH patients with predominant storage LUTS merits further evaluation with larger trials" - ReliableRXPharmacy carries tadalafil.
• Effects of taking tadalafil 5 mg once daily on erectile function and total testosterone levels in patients with metabolic syndrome - Andrologia. 2017 Mar 15 - "All the patients received 5 mg tadalafil once a day for 3 months ... International Index of Erectile Function (IIEF) questionnaire ... At the end of 3 months, mean testosterone values and IIEF scores showed an improvement from baseline values (from 3.6 ± 0.5 to 5.2 ± 0.3, from 11.3 ± 1.9 to 19 ± 0.8 respectively). After the treatment, serum LH levels were decreased (from 5.6 ± 0.6 to 4.6 ± 0.5). There was significantly difference in terms of baseline testosterone and luteinising hormone values and IIEF scores (p < .05). Based on our findings, we recommend tadalafil 5 mg once daily in those men with erectile dysfunction especially low testosterone levels accompanied by metabolic syndrome" - Note: That's a 44% increase in testosterone by my calculations.
• Tadalafil - a therapeutic option in the management of BPH-LUTS - Int J Clin Pract. 2014 Jan;68(1):94-103 - "While tadalafil is most frequently recognised as a standard treatment option for men with ED, it also represents a well-tolerated and effective treatment option in men with moderate to severe BPH-LUTS"
• Efficacy and Safety of Tadalafil 5 mg Once Daily for Lower Urinary Tract Symptoms Suggestive of Benign Prostatic Hyperplasia: Subgroup Analyses of Pooled Data From 4 Multinational, Randomized, Placebo-controlled Clinical Studies - Urology. 2013 Jul 19 - "The safety database included 1500 men randomized to tadalafil 5 mg once daily or placebo for 12 weeks ... In these pooled data analyses, tadalafil 5 mg improved LUTS/BPH across subgroups of age, LUTS severity, testosterone levels, and prostate volume"
• Tadalafil : In the Treatment of Signs and Symptoms of Benign Prostatic Hyperplasia with or without Erectile Dysfunction - Drugs Aging. 2012 Sep;29(9):771-81 - "Once-daily tadalafil 5 mg was effective in treating the signs and symptoms of benign prostatic hyperplasia (BPH). In phase III trials in men with BPH, the mean change from baseline to week 12 in the total International Prostate Symptom Score (IPSS; primary endpoint) was significantly greater in those treated with once-daily tadalafil 5 mg than with placebo. Improvements in total IPSS that occurred over the initial 12 weeks of tadalafil treatment were maintained with continued treatment over a 1-year period in an open-label extension study. Moreover, tadalafil was effective in treating both erectile dysfunction (ED) and the signs and symptoms of BPH in a phase III trial that specifically enrolled men with both indications. Both the International Index of Erectile Function-Erectile Function domain score and the total IPSS (co-primary endpoints) were significantly improved from baseline to week 12 after treatment with once-daily tadalafil 5 mg compared with placebo"
• Losartan improves erectile dysfunction in diabetic patients: a clinical trial - Int J Impot Res. 2012 Aug 30 - "A total of 124 diabetic patients with ED were included in this study and treated with losartan or tadalafil or losartan plus tadalafil or watch for waiting as control for 12 weeks ... Losartan or tadalafil or losartan plus tadalafil significantly improved the mean IIEF-5 scores ... The combination of losartan and tadalafil is more effective than the single-use of losartan or tadalafil" - See losartan and tadalafil at OffshoreRx1.com.
• Influence of a single dose of 20 mg tadalafil, a phosphodiesterase 5 inhibitor, on ambulatory blood pressure in subjects with hypertension - Br J Clin Pharmacol. 2006 Sep;62(3):280-7 - "Overall tadalafil reduced mean ambulatory blood pressure monitor systolic and diastolic blood pressure by 4.8 mmHg [95% confidence interval (Cl) 3.7, 5.9; P < 0.01] and 2.9 mmHg (95% CI 1.9, 3.6; P < 0.01), respectively, compared with placebo. In hypertensive subjects with uncontrolled blood pressure on two to four classes of antihypertensive agents (n = 36) tadalafil reduced mean ABPM systolic and diastolic blood pressure by 7.5 mmHg (95% CI 5.4, 9.6; P < 0.01) and 4.3 mmHg (95% CI 6.1, 8.9; P < 0.01) compared with placebo"
• Tadalafil vs sildenafil patient preference in Spanish men with erectile dysfunction: results from an International Multicentric Study - Actas Urol Esp. 2006 Jan;30(1):67-79 - "7 out of 10 patients preferred tadalafil and its dosing instructions to sildenafil, for the treatment of their ED"
• Testosterone and erectile function in hypogonadal men unresponsive to tadalafil: results from an open-label uncontrolled study - Andrologia. 2006 Apr;38(2):61-8 - "These data suggest that combination therapy with testosterone and tadalafil is an effective means in a subset of hypogonadal patients who did not respond to tadalafil alone"