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Home > Anti-aging Research > Cayenne/Capsicum (Capsicum frutescens).

Cayenne/Capsicum (Capsicum frutescens)

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  • Chili pepper extends lifespan in a concentration-dependent manner and confers cold resistance on Drosophila melanogaster cohorts by influencing specific metabolic pathways - Food Funct 2022 Jul 17 - "Recent prospective cohort studies showed that the regular use of chili pepper improves healthspan in humans. Indeed, chili pepper fruits contain phenolic substances which are structurally similar to those that show anti-aging properties ... Chili powder added to food in concentrations of 0.04%-0.12% significantly extended median lifespan in fruit fly cohorts of both genders by 9% to 13%. However, food supplemented with 3% chili powder shortened lifespan of male cohorts by 9%. Lifespan extension was accompanied by a decrease in age-independent mortality (i.e., death in early ages). The metabolic changes caused by consumption of chili-supplemented food had a pronounced dependence on gender. A characteristic of both fruit fly sexes that ate chili-supplemented food was an increased resistance to cold shock. Flies of both sexes had lower levels of hemolymph glucose when they ate food supplemented with low concentrations of chili powder, as compared with controls. However, males fed on food with 3% chili had lower levels of storage lipids and pyruvate reducing activity of lactate dehydrogenase compared with controls. Females fed on this food showed lower activities of hexokinase and pyruvate kinase, as well as lower ADP/O ratios, compared with control flies" - See capsicum at Amazon.com.
  • Anti-invasive and anti-metastatic activity of capsaicin and natural capsaicin-like compounds in lung adenocarcinoma - FASEB J 2022 May - "Lung adenocarcinoma (LAC) accounts for about 65% of all non-small cell lung cancer (NSCLC) cases. A considerable proportion of LAC patients present (in the clinic) with local and distant metastasis at the time of their diagnosis. One of the earliest events of the metastatic pathway is the invasion of malignant cells through the surrounding extracellular basement membrane into the neighboring blood vessels and lymph nodes ... Capsaicin is the pungent ingredient of chili peppers. Published reports have revealed that capsaicin inhibits the invasion and metastasis of several types of human cancers including melanoma, prostate cancer, and cholangiosarcoma ... capsaicin inhibits the invasion of human LAC cells via the TRPV6 receptor and the tyrosine phosphatase activity pathway" - See capsicum at Amazon.com.
  • Capsaicin Attenuates Arterial Calcification Through Promoting SIRT6-Mediated Deacetylation and Degradation of Hif1α (Hypoxic-Inducible Factor-1 Alpha) - Hypertension 2022 Mar 2 - "Sustained Hif1α (hypoxic-inducible factor-1 alpha) accumulation plays a central role in osteogenic transdifferentiation and subsequent calcification. Capsaicin, the potent agonist of TRPV1 (transient receptor potential vanilloid type 1), was found to mitigate hypoxic-related injury and reverse phenotypic switch of vascular smooth muscle cells. However, its role in arterial calcification and the underlying mechanisms remain unexplored ... Capsaicin facilitates deacetylation and degradation of Hif1α by upregulating SIRT6, which inhibits osteogenic transdifferentiation and protects against arterial calcification"
  • Chili pepper intake and all-cause and disease-specific mortality - Int J Vitam Nutr Res 2022 Jan 18 - "Chili pepper has been used for the treatment and prevention of multiple diseases. This may be due to its abundance of bioactive components, such as carotenoids, which are well known for their antioxidant properties. To date, several prospective cohort studies have examined the association between chili pepper intake and mortality, but the results have not been consistent. This study aimed to clarify the association between chili pepper intake and all-cause and disease-specific mortality using a meta-analysis ... Compared to none or rare consumption of chili pepper, consumption of chili pepper (ever or more than once a week) could significantly reduce the risk of all-cause mortality (summary adjusted HR: 0.87, 95% CI: 0.85, 0.90), CVD-specific mortality (summary adjusted HR: 0.89, 95% CI: 0.85, 0.93), and cancer-specific mortality (summary adjusted HR: 0.92, 95% CI: 0.88, 0.97). There was no significant between-study heterogeneity in the analyses (all-cause mortality: I2=0.7%, P=0.389; CVD-specific mortality: I2=21.8%, P=0.280; cancer-specific mortality: I2=0.0%, P=0.918)"
  • Capsaicin and Its Effects on Body Weight - J Am Coll Nutr 2021 Aug 12 - "Capsaicin is a bioactive compound found in the fruits (i.e., peppers) of the plant genus Capsicum, which is widely used in many cultures. Besides many health effects of this compound, it can also be effective in body weight control through various mechanisms such as regulating lipolysis in adipocytes, increasing the feeling of satiety, stimulating energy expenditure, and reducing energy intake ... Capsaicin can decrease hunger through hormones in the gastrointestinal tract ... Capsaicin can increase energy expenditure through brown adipose tissue ... Capsaicin can increase lipolysis in white adipose tissue"
  • Chronic capsiate supplementation increases fat-free mass and upper body strength but not the inflammatory response to resistance exercise in young untrained men: a randomized, placebo-controlled and double-blind study - J Int Soc Sports Nutr 2021 Jun 21 - "Acute capsaicinoid and capsinoid supplementation has endurance and resistance exercise benefits ... Twenty untrained men were randomized to ingest 12 mg Capsiate (CAP) or placebo in a parallel, double-blind design ... Chronic Capsiate supplementation combined with resistance training during short period (6 weeks) increased fat-free mass and upper body strength but not inflammatory response and performance in young untrained men" - See capsicum at Amazon.com and iHerb.
  • The Beneficial Effects of Red Sun-Dried Capsicum annuum L. cv Senise Extract with Antioxidant Properties in Experimental Obesity are Associated with Modulation of the Intestinal Microbiota - Mol Nutr Food Res 2020 Dec 10 - "Mice fed a high fat diet (HFD) were orally treated with an extract from these peppers (CAE) (1, 10 and 25 mg/kg/day). It promoted weight loss and improved plasma markers related to glucose and lipid metabolisms. CAE also ameliorated obesity-associated systemic inflammation reducing the expression of pro-inflammatory cytokines in adipose and hepatic tissues and improving the expression of different markers involved in the gut epithelial barrier function. These effects were associated with a modulation of the intestinal microbiome, which appears altered"
  • Effects of Capsaicin Coadministered with Eicosapentaenoic Acid on Obesity-Related Dysregulation in High-Fat-Fed Mice - Biol Pharm Bull. 2017;40(9):1581-1585 - "Obesity-induced inflammation contributes to the development of metabolic disorders such as insulin resistance, type 2 diabetes, fatty liver disease, and cardiovascular disease. In this study, we investigated whether the combination of eicosapentaenoic acid (EPA) and capsaicin could protect against high-fat diet (HFD)-induced obesity and related metabolic disorders ... our study suggests that the combination of EPA and capsaicin might be beneficial for delaying the progression of obesity-related metabolic dysregulation and subsequent complications"
  • Effects of twelve weeks of capsaicinoid supplementation on body composition, appetite and self-reported caloric intake in overweight individuals - Appetite. 2017 Feb 21 - "These data suggest that H-CAP supplementation reduces self-reported energy intake after 12 weeks of supplementation, and L-CAP supplementation also reduces waist: hip ratio" - [Nutra USA] - See Capsimax® at Amazon.com.
  • Capsaicinoids Supplementation Reduces Appetite and Body Circumferences in Healthy Men and Women A Placebo Controlled Randomized Double Blind Study - The FASEB Journal Mar 2016 - "randomly assigned by fat mass to ingest either CAP (2mg CAP, CX1 or 4mg CAP, CX2 [CX, Capsimax®, OmniActive Health Technologies Ltd.]) or placebo (corn starch, PLA) for 12 weeks ... baseline (T1), 6 weeks (T2) and 12 weeks (T3) ... Waist: hip ratio measurements showed a main effect for time (p = 0.034) with post-hoc tests revealing a significant (p = 0.024) decrease in CX1 from T1 to T2. Appetite questionnaire responses indicated a significant main effect for time from T1 to T2 (p = 0.004) and T1 to T3 (p = 0.001) suggesting supplementation of CAP reduced appetite" - [Nutra USA]
  • Synergistic anti-cancer activity of Capsaicin and 3,3'-Diindolylmethane in human colorectal cancer - J Agric Food Chem. 2015 Apr 15 - "The present study suggests capsaicin and DIM work synergistically to inhibit cell proliferation and induce apoptosis in colorectal cancer through modulating transcriptional activity of NF-κB, p53 and target genes associated with apoptosis" - See capsaicin supplements at Amazon.com and diindolylmethane at Amazon.com.
  • Dietary Capsaicin Ameliorates Pressure Overload-Induced Cardiac Hypertrophy and Fibrosis Through the Transient Receptor Potential Vanilloid Type 1 - Am J Hypertens. 2014 May 23 - "Dietary capsaicin plays a protective role in hypertension, atherosclerosis, obesity, and hyperlipidemia through activating the transient receptor potential vanilloid type 1 (TRPV1), a nonselective cation channel ... Our results suggest that dietary capsaicin protects against cardiac hypertrophy and fibrosis in pressure overload mice through TRPV1"
  • Antitumor Activity of Capsaicin on Human Colon Cancer Cells in Vitro and Colo 205 Tumor Xenografts in Vivo - J Agric Food Chem. 2010 Nov 17 - "capsaicin induced cytotoxic effects in a time- and dose-dependent manner and increased reactive oxygen species (ROS) and Ca(2+) but decreased the level of mitochondrial membrane potential (ΔΨ(m)) in colo 205 cells. Data from Western blotting analysis indicated that the levels of Fas, cytochrome c, and caspases were increased, leading to cell apoptosis. Capsaicin decreased the levels of anti-apoptotic proteins such as Bcl-2 and increased the levels of pro-apoptotic proteins such as Bax. Capsaicin-induced apoptosis in colo 205 cells was also done through the activations of caspase-8, -9 and -3. In vivo studies in immunodeficient nu/nu mice bearing colo 205 tumor xenografts showed that capsaicin effectively inhibited tumor growth. The potent in vitro and in vivo antitumor activities of capsaicin suggest that capsaicin might be developed for the treatment of human colon cancer"