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Home > Anti-aging Research > Chondroitin.


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  • Scientists reverse age-related memory loss in mice - Science Daily, 7/22/21 - "Recent evidence has emerged of the role of perineuronal nets (PNNs) in neuroplasticity -- the ability of the brain to learn and adapt -- and to make memories. PNNs are cartilage-like structures that mostly surround inhibitory neurons in the brain. Their main function is to control the level of plasticity in the brain. They appear at around five years old in humans, and turn off the period of enhanced plasticity during which the connections in the brain are optimised. Then, plasticity is partially turned off, making the brain more efficient but less plastic ... PNNs contain compounds known as chondroitin sulphates. Some of these, such as chondroitin 4-sulphate, inhibit the action of the networks, inhibiting neuroplasticity; others, such as chondroitin 6-sulphate, promote neuroplasticity. As we age, the balance of these compounds changes, and as levels of chondroitin 6-sulphate decrease, so our ability to learn and form new memories changes, leading to age-related memory decline"
  • Chondroitin sulfate as good as widely used anti-inflammatory for knee osteoarthritis - Science Daily, 5/23/17 - "They conclude that a daily dose of 800 mg of pharmaceutical-grade chondroitin sulfate is better than a dummy product and as good as celecoxib in reducing pain and improving joint function in symptomatic knee osteoarthritis" - See chondroitin sulfate at Amazon.com.
  • Chrondroitin outperforms celecoxib in knee osteoarthritis study - Science Daily, 11/7/15 - "studied 194 people with knee OA and inflammation of the synovial membrane in the knee. The participants were followed for two years and were divided into two groups. The first group took 1200mg (pharmacological preparation) of chondroitin daily, and the second group took 200mg of celecoxib daily ... At both one and two years, the researchers found a better reduction of cartilage loss in the whole knee, and more particularly in the inner half, of the participants on chondroitin when compared to those on celecoxib. Additionally, there was a decrease in synovial membrane thickness in some of the participants on chondroitin, showing far better results for this group ... This study demonstrates that both chondroitin sulfate and celecoxib are equally effective at reducing the symptoms of knee OA patients. However, only chondroitin sulfate was found to be capable of slowing down the progression of the disease by reducing the loss of cartilage"
  • Chondroitin/Glucosamine Reduced Pain in Knee Arthritis in RCT - Medscape, 1/30/15 - "a combination glucosamine/chondroitin sulfate product produced a 50.1% decrease in Western Ontario and McMaster OA index (WOMAC) pain, which is comparable to the 50.2% decrease seen in patients randomly assigned to receive celecoxib ... Patients received either chondroitin sulfate 400 mg plus glucosamine hydrochloride 500 mg (CS+GH; Droglican, Bioibérica SA) three times a day or celecoxib 200 mg every day for 6 months"
  • Association Between use of Specialty Dietary Supplements and C-Reactive Protein Concentrations - Medscape, 12/28/12 - "In summary, this study adds support to laboratory research and to some human studies which suggest that glucosamine, chondroitin, and fish oil may reduce systemic inflammation. In doing so, this study adds biologic plausibility to previous studies which have shown beneficial effects of these supplements on chronic diseases. Given the number of diseases with which inflammation is associated, such as cancer and cardiovascular disease, there is a need to find safe and effective ways to reduce inflammation. Research suggests that these 3 supplements have excellent safety profiles, [88–92] supporting their potential role in disease prevention" - See glucosamine products at Amazon.com, chondroitin sulfate at Amazon.com, Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
  • Glucosamine, Chondroitin, Fish Oil May Reduce Inflammation - Medscape, 11/27/12 - "Inflammation is now recognized as a factor in cancer and cardiovascular disease as well as many rheumatoid diseases ... the researchers found hs-CRP reductions of 17% (95% confidence interval [CI], 7% - 26%) with glucosamine, 22% (95% CI, 8% - 33%) with chondroitin, and 16% (95% CI, 0.3% - 29%) with fish oil compared with participants who did not take the supplements"
  • In People with Hand Osteoarthritis, Chondroitin Sulphate Therapy for 6 Months Improves Pain and Function Compared With Placebo - Medscape, 11/20/12 - "Osteoarthritis of the finger joints is present in about 10% of individuals aged 40 to 49, rising to 92% in individuals over 70 years of age ... Patients were of either sex, aged 40 years and older and given 800 mg of chondroitin sulphate as a single tablet each day or placebo for a total period of 6 months. The chondroitin preparation contained highly purified chondroitins 4 and 6 sulphate of fish origin ... Improvement in the patient's assessment of global hand pain on the VAS was significantly more pronounced in the chondroitin sulphate group than in the placebo group. The decrease in the FIHOA score demonstrated similar pattern. The relative benefit of chondroitin sulphate on both primary end points became evident only after 3 months of treatment. No serious adverse reaction occurred in any study patients"
  • Joint Supplements for Aromatase Inhibitor Adverse Effects - Medscape, 11/18/11 - "Aromatase inhibitors are widely used in the treatment of breast cancer but are associated with significant musculoskeletal adverse effects, including joint pain and stiffness ... We know that these symptoms are unresponsive to conventional pain medication and often lead to low adherence to aromatase inhibitor therapy ... The cohort consisted of postmenopausal breast cancer patents with stage I to III disease who had been on aromatase therapy for at least 3 months, who reported a pain rating of 4 or higher on a 10-point visual analog scale, and whose pain worsened after initiating treatment with aromatase inhibitors if they had preexisting osteoarthritis ... Participants took 1500 mg/day of glucosamine and 1200 mg/day of chondroitin, and were evaluated every 6 weeks at the clinic ... There was a drop in pain and stiffness in the hips and knees at 12 and 24 weeks, as well as improvement in function. "This affected about 50% of the women," she explained. "We saw a very similar pattern looking at the hands and the wrist. We saw similar results with the Brief Pain/Stiffness Inventory — with about 35% to 50% of women.""
  • Chondroitin sulfate improves hand function, relieves morning stiffness caused by osteoarthritis, study finds - Science Daily, 9/6/11 - "OA -- the most common form of arthritis -- affects more than 27 million adults in the U.S., causing joint pain and stiffness ... 20% to 30% of adults have OA of the hand, with the prevalence rising to more than 50% after 60 years of age ... Participants received either 800 mg of chondroitin sulfate (80 patients) or placebo (82 patients) once daily for 6 months ... patients in the chondroitin sulfate group had significant decrease in global hand pain compared with the placebo group, reflecting an 8.7 decrease on the VAS. Hand function also improved significantly for those taking chondroitin sulfate, decreasing more than 2 points on the FIHOA. Researchers also reported significantly improved hand function and reduction in morning stiffness for participants taking chondroitin sulfate versus placebo ... Alternative therapies, such as nonsteroidal anti-inflammatory drugs (NSAIDs), provide similar pain reducing effects, but with considerably more long-term toxicities"
  • Chondroitin Slows Progression And Relieves Symptoms Of Knee Osteoarthritis - Science Daily, 1/29/09 - "long-term administration of CS over 2 years can prevent joint structure degradation in patients with knee OA ... Joint space loss was significantly reduced in the CS group, fewer patients had progression of joint space width, and CS reduced pain in those taking it compared to the placebo group. CS was well-tolerated and there were no significant differences in the frequency of adverse events between the two groups"
  • Chondroitin No Help for Arthritis Pain - WebMD, 4/16/07
  • Joint Supplements (Glucosamine, Chondroitin, and MSM) review - ConsumerLab.com, 4/12/07 - "eight supplements for osteoarthritis failed ConsumerLab's testing. Four of had less than 8% of their listed amounts of key ingredients, including a "maximum strength" product that contained no chondroitin at all. Three others had only 52% to 75% of listed ingredients. One failed because it would not properly break apart to release its glucosamine and chondroitin"
  • Arthritis supplements often come up short - MSNBC, 4/11/07 - "All the problems popped up among products that claimed to contain chondroitin, a key — and pricey — ingredient. Of 11 such brands, eight came up short on the substance, which is purported to inhibit enzymes that break down the cartilage in joints"
  • Efficacy of Glucosamine and Chondroitin Sulfate May Depend on Level of Osteoarthritis Pain - Doctor's Guide, 2/24/06
  • Efficacy Of Glucosamine, Chondroitin Sulfate May Depend On Level Of Osteoarthritis Pain - Science Daily, 2/23/06 - "The popular dietary supplements glucosamine and chondroitin sulfate proved no better than a placebo in relieving osteoarthritis knee pain in most participants of a major national trial. But the study, published in the Feb. 23 issue of the New England Journal of Medicine, also showed a smaller subgroup of trial patients with moderate to severe osteoarthritis knee pain taking the combination of the two supplements experienced significant pain relief"
  • Arthritis Supplements in Question - WebMD, 2/22/06 - "Osteoarthritis patients with mild pain treated for six months with the glucosamine and chondroitin sulfate, either alone or in combination, experienced no greater pain relief than patients randomly assigned to take a placebo ... Those with moderate to severe knee pain who took a combination of the two supplements did report significantly greater pain relief than patients with the same degree of pain who took a placebo"
  • Popular supplements fail to ease arthritis pain - MSNBC, 2/22/06 - "The popular supplements, glucosamine and chondroitin sulfate — once used even by President Bush — were no better than dummy pills at pain relief ... At the same time, the supplements did seem to help people with more severe arthritis"
  • New NIH Study Confirms that Chondroitin and Glucosamine Are Effective Against Osteoarthritis - Doctor's Guide, 11/16/05 - "the combination of chondroitin sulfate and glucosamine is effective in treating moderate to severe knee pain due to ostearthritis"
  • Supplements May Help Knee Arthritis - WebMD, 11/14/05 - "patients with more severe arthritis pain got significant relief from the glucosamine-chondroitin combination"
  • Treating and Beating Arthritis - US News, 6/27/05 - "One popular supplement, called glucosamine-chondroitin, really seems to work"
  • Good News for People with Osteoarthritis - Healthwell, 5/20/04 - "People who experience pain and poor joint function in the knees due to osteoarthritis (OA) may reduce symptoms by intermittently taking oral chondroitin sulfate"
  • Oral Chondroitin Sulfate Appears Safe, Effective in Reducing Pain, Improving Knee Function In Knee Osteoarthritis - Doctor's Guide, 4/2/04
  • Chondroitin Sulfate Decreases Pain and Improves Knee Function in Patients with Knee Osteoarthritis - Doctor's Guide, 3/31/04 - "Oral chondroitin sulfate (CS) appears to decrease pain and improve knee function in patients with knee osteoarthritis (OA), say researchers. In addition, CS may inhibit medial femoro-tibial joint space narrowing, suggesting that the treatment has structure-modifying properties"
  • Glucosamine, Chondroitin Seem to Work - WebMD, 7/17/03
  • Glucosamine Has Structural/Symptomatic Efficacy while Chondroitin Has Symptomatic Efficacy in Knee Osteoarthritis - Doctor's Guide, 7/17/03 - "Glucosamine has structural efficacy and both glucosamine and chondroitin have indistinguishable symptomatic efficacies in knee osteoarthritis"
  • Topical Glucosamine/Chondroitin Cream Relieves Knee Osteoarthritic Pain - Doctor's Guide, 4/14/03
  • Natural Remedies for Osteoarthritis: Now, More than Ever - New Hope Natural Media, 8/15/02 - "The most widely used product is glucosamine sulfate. Numerous studies have shown that this substance, which helps rebuild damaged cartilage, relieves pain at least as effectively as NSAIDs, and is relatively free of side effects ... Chondroitin sulfate, a component of the connective tissue that makes up joint cartilage, has also been studied extensively ... Some doctors recommend niacinamide (vitamin B3) ... Other natural substances that have been reported to relieve the symptoms of OA include vitamin E (600 to 1,200 IU per day), Devil's claw, cat's claw and ginger root"
  • New Concepts Of Osteoarthritis Pathogenesis And Management Guidelines - Doctor's Guide, 6/14/01 - "Nutraceuticals, such as glucosamine and chondroitin sulfate, have been shown to relieve pain in a number of studies and modify the pathophysiology of the disease"
  • Chondroitin Eases Pain, Too - Nutrition Science News, 4/01
  • Chondroitin Sulfate a Big Hit - Nutrition Science News, 7/00
  • Glucosamine vs. Chondroitin - Nutrition Science News, 7/00
  • NIH conducts large study into promising reports of glucosamine easing arthritis pain - CNN, 4/7/00
  • Joint Remedies Face Off - Nutrition Science News, 4/00
  • Chondroitin & Glucosamine: New Forms Stand Up to Arthritis - Life Enhancement Magazine, 5/99