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Glucosamine Sulfate

Related Topics:

• chondroitin / arthritis

Specific Recommendations:

• Glucosamine hydrochloride at Amazon.com and iHerb
• Glucosamine chondroitin formulas at Amazon.com

News & Research:

• Researchers discover fundamental roles of glucosamine in brain - Science Daily, 5/26/21 - "Using biochemical approaches, the researchers determined the sugar composition of glycogen in the muscle, liver, and brain of mice. Unlike muscle glycogen, which had only 1% glucosamine, and liver glycogen, which had less than 1% glucosamine, brain glycogen contained 25% glucosamine" - See glucosamine hydrochloride at Amazon.com.
• Glucosamine may reduce overall death rates as effectively as regular exercise, study suggests - Science Daily, 12/1/20 - "taking glucosamine/chondroitin every day for a year or longer was associated with a 39 percent reduction in all-cause mortality ... It was also linked to a 65 percent reduction in cardiovascular-related deaths" - See glucosamine chondroitin formulas at Amazon.com and iHerb.
• Glucosamine Supplements Linked to Lower CVD Event Risks - Medscape, 5/14/19 - "Glucosamine use was associated with a 15% lower risk for total CVD events and a 9% to 22% lower risk for stroke, coronary heart disease (CHD), and CVD death after adjustment for age, sex, body mass index, race, lifestyle factors, diet, medications, and other supplements ... A few other cohort studies have raised this question including the Vitamins and Lifestyle (VITAL) cohort study, in which high glucosamine use (at least 4 days per week for at least 3 years) was associated with a 17% lower adjusted total mortality risk ... the associations may be driven by the anti-inflammatory properties of glucosamine or that the popular supplement may mimic a low carbohydrate diet by decreasing glycolysis and increasing amino acid catabolism"
• Chondroitin/Glucosamine Reduced Pain in Knee Arthritis in RCT - Medscape, 1/30/15 - "a combination glucosamine/chondroitin sulfate product produced a 50.1% decrease in Western Ontario and McMaster OA index (WOMAC) pain, which is comparable to the 50.2% decrease seen in patients randomly assigned to receive celecoxib ... Patients received either chondroitin sulfate 400 mg plus glucosamine hydrochloride 500 mg (CS+GH; Droglican, Bioibérica SA) three times a day or celecoxib 200 mg every day for 6 months"
• Association Between use of Specialty Dietary Supplements and C-Reactive Protein Concentrations - Medscape, 12/28/12 - "In summary, this study adds support to laboratory research and to some human studies which suggest that glucosamine, chondroitin, and fish oil may reduce systemic inflammation. In doing so, this study adds biologic plausibility to previous studies which have shown beneficial effects of these supplements on chronic diseases. Given the number of diseases with which inflammation is associated, such as cancer and cardiovascular disease, there is a need to find safe and effective ways to reduce inflammation. Research suggests that these 3 supplements have excellent safety profiles, [88–92] supporting their potential role in disease prevention" - See glucosamine products at Amazon.com, chondroitin sulfate at Amazon.com, Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
• Glucosamine, Chondroitin, Fish Oil May Reduce Inflammation - Medscape, 11/27/12 - "Inflammation is now recognized as a factor in cancer and cardiovascular disease as well as many rheumatoid diseases ... the researchers found hs-CRP reductions of 17% (95% confidence interval [CI], 7% - 26%) with glucosamine, 22% (95% CI, 8% - 33%) with chondroitin, and 16% (95% CI, 0.3% - 29%) with fish oil compared with participants who did not take the supplements"
• Joint Supplements for Aromatase Inhibitor Adverse Effects - Medscape, 11/18/11 - "Aromatase inhibitors are widely used in the treatment of breast cancer but are associated with significant musculoskeletal adverse effects, including joint pain and stiffness ... We know that these symptoms are unresponsive to conventional pain medication and often lead to low adherence to aromatase inhibitor therapy ... The cohort consisted of postmenopausal breast cancer patents with stage I to III disease who had been on aromatase therapy for at least 3 months, who reported a pain rating of 4 or higher on a 10-point visual analog scale, and whose pain worsened after initiating treatment with aromatase inhibitors if they had preexisting osteoarthritis ... Participants took 1500 mg/day of glucosamine and 1200 mg/day of chondroitin, and were evaluated every 6 weeks at the clinic ... There was a drop in pain and stiffness in the hips and knees at 12 and 24 weeks, as well as improvement in function. "This affected about 50% of the women," she explained. "We saw a very similar pattern looking at the hands and the wrist. We saw similar results with the Brief Pain/Stiffness Inventory — with about 35% to 50% of women.""
• Omega-3 plus glucosamine ‘superior’ for joint health: Study - Nutra USA, 11/30/09
• Current Role of Glucosamine in the Treatment of Osteoarthritis - Medscape, 6/5/07 - "These results suggest that patients with a less severe radiographic knee OA will be particularly responsive to GS as a structure-modifying drug"
• Joint Supplements (Glucosamine, Chondroitin, and MSM) review - ConsumerLab.com, 4/12/07 - "eight supplements for osteoarthritis failed ConsumerLab's testing. Four of had less than 8% of their listed amounts of key ingredients, including a "maximum strength" product that contained no chondroitin at all. Three others had only 52% to 75% of listed ingredients. One failed because it would not properly break apart to release its glucosamine and chondroitin"
• Efficacy of Glucosamine and Chondroitin Sulfate May Depend on Level of Osteoarthritis Pain - Doctor's Guide, 2/24/06
• Efficacy Of Glucosamine, Chondroitin Sulfate May Depend On Level Of Osteoarthritis Pain - Science Daily, 2/23/06 - "The popular dietary supplements glucosamine and chondroitin sulfate proved no better than a placebo in relieving osteoarthritis knee pain in most participants of a major national trial. But the study, published in the Feb. 23 issue of the New England Journal of Medicine, also showed a smaller subgroup of trial patients with moderate to severe osteoarthritis knee pain taking the combination of the two supplements experienced significant pain relief"
• Arthritis Supplements in Question - WebMD, 2/22/06 - "Osteoarthritis patients with mild pain treated for six months with the glucosamine and chondroitin sulfate, either alone or in combination, experienced no greater pain relief than patients randomly assigned to take a placebo ... Those with moderate to severe knee pain who took a combination of the two supplements did report significantly greater pain relief than patients with the same degree of pain who took a placebo"
• Popular supplements fail to ease arthritis pain - MSNBC, 2/22/06 - "The popular supplements, glucosamine and chondroitin sulfate — once used even by President Bush — were no better than dummy pills at pain relief ... At the same time, the supplements did seem to help people with more severe arthritis"
• New NIH Study Confirms that Chondroitin and Glucosamine Are Effective Against Osteoarthritis - Doctor's Guide, 11/16/05 - "the combination of chondroitin sulfate and glucosamine is effective in treating moderate to severe knee pain due to ostearthritis"
• Supplements May Help Knee Arthritis - WebMD, 11/14/05 - "patients with more severe arthritis pain got significant relief from the glucosamine-chondroitin combination"
• Glucosamine better than common painkiller for knee arthritis - Nutra USA, 10/3/05
• Treating and Beating Arthritis - US News, 6/27/05 - "One popular supplement, called glucosamine-chondroitin, really seems to work"
• Use of Glucosamine Sulphate for Osteoarthritis Appears to Have Disease-Modifying Effect in Postmenopausal Women - Doctor's Guide, 3/24/04 - "After 3 years, postmenopausal participants in the glucosamine sulphate group showed no joint space narrowing (joint space change of +0.003 mm), whereas participants in the placebo group experienced a narrowing of -0.33 mm"
• Glucosamine Stops Knee Arthritis in Women - WebMD, 3/15/04 - "The popular supplement glucosamine could do more than just ease arthritis knee pain. New research indicates that it may actually stop disease progression -- and possibly reverse it"
• Glucosamine Ups Ibuprofen's Pain Relief - WebMD, 1/9/04 - "While the NSAID administered alone had pain-relieving effects, glucosamine administered alone produced no pain-relieving effect ... But when glucosamine was combined with an NSAID, pain relief was more pronounced" - See ibuprofen at Amazon.com and iHerb glucosamine products.
• Cirque choreographer promotes new twist on joint health - USA Today, 9/9/03
• Glucosamine, Chondroitin Seem to Work - WebMD, 7/17/03
• Glucosamine Has Structural/Symptomatic Efficacy while Chondroitin Has Symptomatic Efficacy in Knee Osteoarthritis - Doctor's Guide, 7/17/03 - "Glucosamine has structural efficacy and both glucosamine and chondroitin have indistinguishable symptomatic efficacies in knee osteoarthritis"
• Topical Glucosamine/Chondroitin Cream Relieves Knee Osteoarthritic Pain - Doctor's Guide, 4/14/03
• New Study Suggests Expanded Benefits of Glucosamine - New Hope Natural Media, 4/3/03
• Glucosamine for Knees -- Evidence Builds - WebMD, 1/27/03 - "the biggest benefits of glucosamine seemed to be in reducing the amount of perceived pain. By the end of the study, 88% of the glucosamine group said their knee pain had improved compared to only 17% in the placebo group ... After four weeks of treatment, only 36% of users reported some pain relief, but that number grew to 68% at week eight and 88% by week 12"
• Natural Remedies for Osteoarthritis: Now, More than Ever - New Hope Natural Media, 8/15/02 - "The most widely used product is glucosamine sulfate. Numerous studies have shown that this substance, which helps rebuild damaged cartilage, relieves pain at least as effectively as NSAIDs, and is relatively free of side effects ... Chondroitin sulfate, a component of the connective tissue that makes up joint cartilage, has also been studied extensively ... Some doctors recommend niacinamide (vitamin B3) ... Other natural substances that have been reported to relieve the symptoms of OA include vitamin E (600 to 1,200 IU per day), Devil's claw, cat's claw and ginger root"
• Glucosamine Sulfate for Joint Relief - Nutrition Science News, 3/01 - "until last year the long-term effects of GS remained anecdotal ... Two separate three-year studies involving once-daily supplementation of 1,500 mg of a specific brand of glucosamine sulfate, DONA, produced significant symptomatic relief and a reduced progression of knee OA. Additional studies show six weeks of the same product and dosage offers relief for spinal OA, with effects persisting up to four weeks after stopping GS"
• Glucosamine Might Have A Role In Arthritis - Doctor's Guide, 3/1/01 - "Glucosamine might actually be as beneficial as many widely used non-steroidal anti-inflammatory drugs in the treatment of osteoarthritis"
• Scientific Findings Emphasize Glucosamine Value - Council for Responsible Nutrition, 1/26/01
• Supplement Slows Knee Arthritis, Relieves Pain, But Unregulated Glucosamine Products Vary in Quality, Experts Warn - WebMD, 1/25/01
• Dona (Glucosamine Sulfate) Decreases Progression Of Knee Osteoarthritis - Doctor's Guide, 11/2/00
• Glucosamine Sulfate Treats Osteoarthritis - Nutrition Science News, 7/00
• Glucosamine vs. Chondroitin - Nutrition Science News, 7/00
• Glucosamine a New Concern for Diabetes - Nutrition Science News, 6/00
• NIH conducts large study into promising reports of glucosamine easing arthritis pain - CNN, 4/7/00
• Popular supplement may fight osteoarthritis - CNN, 11/15/99
• Allergy-free Glucosamine - Nutrition Science News, 10/99
• Glucosamine - Ray Sahelian, M.D.
• Chronic Joint Pain - Nutrition Science News, 1/99

Abstracts:

• Role of Glucosamine and Chondroitin in the Prevention of Cancer: A Meta-Analysis - Nutr Cancer 2023 Jan 30 - "The anti-inflammatory properties of glucosamine and chondroitin suggest that they may have potential effects in cancer prevention ... Overall, chondroitin and/or glucosamine intake was associated with a lower risk of colorectal cancer (OR = 0.91, 95% CI, 0.87-0.94) and lung cancer (OR = 0.84"  - See glucosamine chondroitin formulas at Amazon.com.
• Comprehensive Rehabilitation Therapy Plus Glucosamine Hydrochloride for Exercise-Induced Knee Injuries and the Effect on Knee Function of Patients - Evid Based Complement Alternat Med 2022 Jun 27 - "To assess the application value of comprehensive rehabilitation therapy plus glucosamine hydrochloride for exercise-induced knee injuries and its effect on knee function ... Comprehensive rehabilitation therapy plus glucosamine hydrochloride effectively improves the clinical efficacy of exercise-induced knee joint injuries and enhances the knee joint rehabilitation of the patients" - See glucosamine hydrochloride at Amazon.com.
• Influence of a low-dose supplementation of curcumagalactomannoside complex (CurQfen) in knee osteoarthritis: A randomized, open-labeled, active-controlled clinical trial - Phytother Res 2020 Nov 18 - "A 6-week, randomized, open-label, active-controlled clinical trial was conducted to evaluate the influence of a low-dose curcumagalactomannosides (CGM) (400 mg once daily) in OA subjects. The treatment was compared with a standard combination of 500 mg glucosamine hydrochloride (GLN) and 415 mg chondroitin sulphate (CHN), supplied as a single oral dose twice a day. Out of 84 subjects randomized, 72 subjects who have completed the study were evaluated for the safety and efficacy of the treatments at baseline and subsequent visits (day 28 and 42), by measuring walking performance, VAS, KPS, and WOMAC scores. CGM exhibited 47.02, 21.43, and 206% improvement in VAS, KPS, and walking performance, respectively, compared to the baseline. Similarly, there was 31.17, 32.93, 36.44, and 35% improvement in the pain, stiffness, physical function, and total WOMAC scores. CGM also caused a substantial reduction in the serum inflammatory marker levels. The results indicate that a short-term supplementation of a low dosage CGM exerted superior beneficial effects than a high-dosage CHN-GLN combination in alleviating the pain and symptoms of OA subjects" - [Nutra USA] - See CurQfen at Amazon.com, curcumin at Amazon.com and iHerb and fenugreek at Amazon.com and iHerb.
• Glucosamine and chondroitin supplements and risk of colorectal adenoma and serrated polyp - Cancer Epidemiol Biomarkers Prev 2020 Oct 14 - "Analyses include 43,163 persons from the Nurses' Health Study (NHS), Health Professionals Follow-up Study (HPFS), and NHS2 who reported on glucosamine/chondroitin use in 2002 and who subsequently underwent ≥1 lower gastrointestinal endoscopy ... Glucosamine/chondroitin use was inversely associated with high-risk and any conventional adenoma in NHS and HPFS: in the pooled multivariable-adjusted model, glucosamine+chondroitin use at baseline was associated with a 26% (OR=0.74, 95% CI=0.60-0.90, P-heterogeneity=0.23) and a 10% (OR=0.90, 95% CI=0.81-0.99, P-heterogeneity=0.36) lower risk of high-risk adenoma and overall conventional adenoma, respectively. However, no association was observed in NHS2, a study of younger women (high-risk adenoma: OR=1.09, 95% CI=0.82-1.45; overall conventional adenoma: OR=1.00, 95% CI=0.86-1.17), and effect estimates pooled across all three studies were not significant (high-risk: OR=0.83; 95% CI=0.63-1.10, P-heterogeneity=0.03; overall conventional adenoma: OR=0.93" - See glucosamine hydrochloride at Amazon.com and iHerb and chondroitin sulfate at Amazon.com and iHerb.
• Curcumagalactomannoside/Glucosamine Combination Improved Joint Health Among Osteoarthritic Subjects as Compared to Chondroitin Sulfate/Glucosamine: Double-Blinded, Randomized Controlled Study - J Altern Complement Med 2020 Jul 14 - "A combination of curcumagalactomannosides (CGM) (400 mg) with glucosamine hydrochloride (GLN) (500 mg) was evaluated against a standard dietary supplement combination chondroitin sulfate (CHN) (415 mg)/GLN (500 mg) for their effectiveness in alleviating the pain and symptoms among osteoarthritic subjects ... CGM-GLN was found to offer significant beneficial effects to pain, stiffness, and physical function of OA subjects compared with CHN-GLN, which was evident from the improvement in walking performance, VAS score, KPS score, and WOMAC score. The efficiency of CGM-GLN was almost double compared with the CHN-GLN by the end of the study (84th day). A significant reduction of inflammatory serum marker levels was observed among CGM-GLN subjects compared with CHN-GLN subjects. Compared with the baseline, CGM-GLN produced 54.52%, 59.08%, and 22.03% reduction in IL-1β, IL-6, and sVCAM levels, respectively. Whereas CHN-GLN group of subjects expressed only 23.17%, 21.38%, and 6.82% reduction in IL-1β, IL-6, and sVCAM levels, respectively" - [Nutra USA] - See curcumin at Amazon.com and iHerb and glucosamine hydrochloride at Amazon.com and iHerb.
• Associations Between Glucosamine and Chondroitin Supplement Use and Biomarkers of Systemic Inflammation - J Altern Complement Med. 2014 Apr 16 - "high-sensitivity C-reactive protein (hsCRP) ... urinary prostaglandin E2-metabolite (PGE-M) ... High users (14 or more pills/week) of chondroitin had 36% lower hsCRP (ratio, 0.64; 95% confidence interval [CI], 0.39-1.04; p for trend=.03) and 27% lower PGE-M (ratio, 0.73; 95% CI, 0.5-0.98; p for trend=.07) than nonusers. Compared with nonusers, high users of glucosamine had 28% lower hsCRP (ratio, 0.72; 95% CI, 0.47-1.08; p for trend=.09) and 24% lower PGE-M (ratio, 0.76; 95% CI, 0.59-0.97; p for trend=0.10)" - See chondroitin sulfate at Amazon.com and glucosamine products at Amazon.com.
• Use of glucosamine and chondroitin supplements and risk of colorectal cancer - Cancer Causes Control. 2013 Mar 26 - "Participants include 75,137 western Washington residents aged 50-76 who completed the mailed VITAL questionnaire between 2000 and 2002. Use of glucosamine and chondroitin was ascertained by questions about supplement use during the 10-year period prior to baseline, and participants were followed for CRC through 2008 ... Persons reporting use of glucosamine + chondroitin on 4+ days/week for 3+ years had a non-statistically significant 45 % lower CRC risk than non-users" - See glucosamine products at Amazon.com and chondroitin sulfate at Amazon.com.
• Glucosamine sulphate in the treatment of knee osteoarthritis: cost-effectiveness comparison with paracetamol - Int J Clin Pract. 2010 May;64(6):756-62 - "The results of the present cost-effectiveness analysis suggested that GS is a highly cost-effective therapy alternative compared with paracetamol and PBO to treat patients diagnosed with primary knee OA"
• Effect of glucosamine sulfate with or without omega-3 fatty acids in patients with osteoarthritis - Adv Ther. 2009 Sep 4 - "The aim was to see if a combination of glucosamine sulfate (1500 mg/day) and the omega-3 polyunsaturated fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) (group A), showed equivalence (noninferiority) or superiority as opposed to glucosamine sulfate alone (group B) ... OA symptoms (morning stiffness, pain in hips and knees) were reduced at the end of the study: by 48.5%-55.6% in group A and by 41.7%-55.3% in group B" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com and glucosamine products at Amazon.com.
• Glucosamine and chondroitin sulfate as therapeutic agents for knee and hip osteoarthritis - Drugs Aging. 2007;24(7):573-80 - "glucosamine sulfate (but not glucosamine hydrochloride) and chondroitin sulfate have small-to-moderate symptomatic efficacy in OA ... glucosamine sulfate and chondroitin sulfate may interfere with progression of OA"
• Oral Glucosamine in Doses Used to Treat Osteoarthritis Worsens Insulin Resistance - Am J Med Sci. 2007 Jun;333(6):333-339 - "We found a rise in HOMA-IR after 6 weeks of glucosamine (2.8 versus 3.2 ... persons with underlying poorer insulin sensitivity are at risk for worsening insulin resistance and vascular function with the use of glucosamine in doses used to treat osteoarthritis"
• Do glucosamine and chondroitin worsen blood sugar control in diabetes? - J Fam Pract. 2006 Dec;55(12):1091-3 - "Despite theoretical risks based on animal models given high intravenous doses, glucosamine/chondroitin (1500 mg/1200 mg daily) does not adversely affect short-term glycemic control for patients whose diabetes is well-controlled, or for those without diabetes or glucose intolerance"
• Oral glucosamine for 6 weeks at standard doses does not cause or worsen insulin resistance or endothelial dysfunction in lean or obese subjects - Diabetes. 2006 Nov;55(11):3142-50
• Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis - N Engl J Med. 2006 Feb 23;354(8):795-808
• The Effect of Glucosamine-Chondroitin Supplementation on Glycosylated Hemoglobin Levels in Patients With Type 2 Diabetes Mellitus - Arch Intern Med. 2003;163:1587-1590 - "oral glucosamine supplementation does not result in clinically significant alterations in glucose metabolism in patients with type 2 diabetes mellitus"
• Glucosamine Sulfate Use and Delay of Progression of Knee Osteoarthritis: A 3-Year, Randomized, Placebo-Controlled, Double-blind Study - Archives of Internal Medicine, 10/14/02 - "Symptoms improved modestly with placebo use but as much as 20% to 25% with glucosamine sulfate use, with significant final differences on the Lequesne index and the WOMAC total index and pain, function, and stiffness subscales"