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Home > Health Conditions > Hip

Hip Fracture/Replacement

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  • Can Metformin Reduce Need for Total Joint Replacement in Diabetes? - Medscape, 12/20/22 - "Compared with nonusers, metformin users had had a 30% lower risk of total knee or hip replacement (adjusted hazard ratio [HR], 0.70). The incidence of total knee replacement among metformin nonusers and users was 4.15 per 10,000 person-months and 2.96 per 10,000 person-months, respectively. The incidence of total hip replacement was 0.83 per 10,000 person-months in nonusers and 0.44 per 10,000 person-months in users ... By joint type, the adjusted HR was 0.71 for total knee replacement and 0.61 for total hip replacement among metformin users ... The effect was observed at daily doses of less than 1 g, as well as daily doses of 1 g or more. "This suggests that metformin at a lower dosage could have effects on osteoarthritis,"" - See metformin at ReliableRX.
  • Relationship between serum vitamin D and hip fracture in the elderly: a systematic review and meta-analysis - J Bone Miner Metab 2022 May 31 - "Low serum vitamin D levels in the elderly are associated with an increase in the odds of hip fracture" - See vitamin D at Amazon.com.
  • Relationship Amongst Vitamin K Status, Vitamin K Antagonist Use and Osteoarthritis: A Review - Drugs Aging 2022 May 30 - "vitamin K antagonists (VKAs) ... in limited retrospective and prospective studies, the use of VKAs is associated positively with OA occurrence and knee/hip replacement" - See vitamin k2 at Amazon.com.
  • Vitamin D deficiency is associated with reduced mobility after hip fracture surgery: a prospective study - Am J Clin Nutr. 2020 Feb 19 - "Compared with patients with <12 ng/mL, those with higher 25(OH)D concentrations had higher rates of walking at 30 d (P = 0.031): 12 to <20 ng/mL (adjusted OR: 2.61; 95% CI: 1.13, 5.99); 20 to <30 ng/mL (3.48; 1.53, 7.95); ≥30 ng/mL (2.84; 1.12, 7.20). In addition, there was also greater mobility at 60 d (P = 0.028) in patients with higher 25(OH)D compared with the reference group (<12 ng/mL)" - [Nutra USA] - See vitamin D at Amazon.com.
  • Magnesium could prevent fractures, say researchers - Science Daily, 4/12/17 - "Bone fractures are one of the leading causes of disability and ill health especially among the aging population and this increases the burden on the health care system. It is well-known that calcium and vitamin D play an important role in bone health. Magnesium is an essential nutrient and is an important component of the bone ... The risk of having a fracture was reduced by 44 per cent in men with higher blood levels of magnesium. None of the 22 men who had very high magnesium levels (> 2.3 mg/dl) in the study population experienced a fracture during the follow-up period" - See Magtein at Amazon.com.  I take two with each meal.
  • Impact of 3-Monthly Vitamin D Supplementation Plus Exercise on Survival after Surgery for Osteoporotic Hip Fracture in Adult Patients over 50 Years: A Pragmatic Randomized, Partially Blinded, Controlled Trial - J Nutr Health Aging. 2017;21(4):413-420 - "Patients were randomized to receive either 3-monthly oral doses of 3 mg calcifediol (Hidroferol Choque®) or placebo in the 12 months postsurgery. Patients who received calcifediol were also given an exercise programme. The placebo group received standard health recommendations only ... At 4 years after surgery, 20 (22.7%) had died, 3 (3.4%) from the intervention group and 17 (19.3%) from the non-intervention group ... 3-monthly, oral supplements of 3 mg calcifediol plus daily exercise improved survival at one-year and four-year follow up after surgery for an osteoporotic hip fracture" - See vitamin D at Amazon.com.
  • Micronutrients and the risk of hip fracture: Case-control study - Clin Nutr. 2015 Dec 23 - "Vitamin D, and possibly vitamin K, has an established association to fracture risk. Other vitamins are, however, less studied ... Low vitamin A, C, and E concentrations are associated with an increased risk of hip fracture, possibly mediated through bone turnover mechanisms"
  • Associations between the dietary intake of antioxidant nutrients and the risk of hip fracture in elderly Chinese: a case-control study - Br J Nutr. 2014 Oct 7:1-9 - "The role of oxidative stress in skeletal health is unclear. The present study investigated whether a high dietary intake of antioxidant nutrients (vitamins C and E, β-carotene, animal-derived vitamin A, retinol equivalents, Zn and Se) is associated with a reduced risk of hip fracture in elderly Chinese ... The OR of hip fracture for the highest (v. lowest) quartile of intake were 0·39 (95 % CI 0·28, 0·56) for vitamin C, 0·23 (95 % CI 0·16, 0·33) for vitamin E, 0·51 (95 % CI 0·36, 0·73) for β-carotene, 0·43 (95 % CI 0·26, 0·70) for Se and 0·24 (95 % CI 0·17, 0·36) for the antioxidant score. A moderate-to-high dietary intake of retinol equivalents in quartiles 2-4 (v. 1) was found to be associated with a lower risk of hip fracture (OR range: 0·51-0·63, P< 0·05)"
  • More Fractures Seen When Vitamin D Is Consistently Low - Medscape, 4/15/14 - "Adequate levels of vitamin D help increase calcium absorption from the gut, and both calcium and vitamin D are important in terms of bone health ... The remaining question, said Dr. Judge, is "Would intervening with the women with the lowest 25OHD levels decrease their risk of fractures?" He continued, "I believe the evidence suggests that the answer is yes. The working hypothesis is that vitamin D reduces fractures in elderly people by improving balance and reducing the risk of falls, rather than through its effect on bone density."" - See Vvitamin D at Amazon.com.
  • Impact of long-term vitamin D insufficiency on fracture risk - Science Daily, 4/4/14 - "Study participants at baseline were 1044 Swedish women, all aged 75, with 715 attending at the 5-year follow up. Serum 25-hydroxyvitamin D (25OHD) levels (nmol/l) were classified as low (<50), intermediate (50 ) and high (>75) ... the incidence of hip fractures within 10 years was significantly lower in those women who were vitamin D sufficient (≥50 nmol/l) at baseline and maintained this level at 5 years. The proportion of women sustaining FRAX fractures was 26.2% and 30% in the group which had consistently high or intermediate 25OHD levels compared to 45.6 % in the group with consistently low levels" - See vitamin D at Amazon.com.
  • Vitamin K1 and 25(OH)D are independently and synergistically associated with a risk for hip fracture in an elderly population: A case control study - Clin Nutr. 2014 Jan 29 - "Vitamin K1 and 25(OH)D are independently and synergistically associated with the risk of hip fracture when adjusting for confounders" - See vitamin K at Amazon.com.
  • Calcium + Vitamin D: Surprises From Long-term Follow-up - Medscape, 12/11/13 - "the analyses that were limited to adherent women who were taking at least 80% of their study pills compared with the women who were taking at least 80% of their placebo pills showed a statistically significant 29% reduction in the risk for hip fracture ... Also shown in the new report is that with longer-term follow-up, a statistically significant reduction in in situ breast cancer emerged -- a 13% reduction overall ... In terms of all cancers, among the women who had low baseline intake of vitamin D, there was a statistically significant 9% reduction in total cancer with supplementation, and also a marginally significant 9% reduction in all-cause mortality" - See vitamin D at Amazon.com.
  • Intake and serum concentrations of α-tocopherol in relation to fractures in elderly women and men: 2 cohort studies - Am J Clin Nutr. 2013 Nov 13 - "Two cohort studies, the Swedish Mammography Cohort (SMC; n = 61,433 women) and the Uppsala Longitudinal Study of Adult Men (ULSAM; n = 1138 men), were used ... A higher hip fracture rate was observed with lower intakes of α-tocopherol. Compared with the highest quintile of intake, the lowest quintile had a multivariable-adjusted HR of 1.86 (95% CI: 1.67, 2.06). The HR of any fracture was 1.20 (95% CI: 1.14, 1.28). α-Tocopherol-containing supplement use was associated with a reduced rate of hip fracture (HR: 0.78; 95% CI: 0.65, 0.93) and any fracture (HR: 0.86; 95% CI: 0.78, 0.94). Compared with the highest quintile of α-tocopherol intake in ULSAM (follow-up: 12 y), lower intakes (quintiles 1-4) were associated with a higher rate of hip fracture (HR: 3.33; 95% CI: 1.43, 7.76) and any fracture (HR: 1.84; 95% CI: 1.18, 2.88). The HR for hip fracture in men for each 1-SD decrease in serum α-tocopherol was 1.58 (95% CI: 1.13, 2.22) and for any fracture was 1.23 (95% CI: 1.02, 1.48)" - See Jarrow FamilE (contains all eight members of the vitamin E family, includes Tocomin) at Amazon.com.
  • Protective effects of dietary carotenoids on risk of hip fracture in men: The Singapore Chinese Health Study - J Bone Miner Res. 2013 Jul 16 - "used data from the Singapore Chinese Health Study, a prospective cohort of 63,257 men and women who were of ages 45-74 years between 1993 and 1998 ... validated food frequency questionnaire. During a mean follow-up of 9.9 years, we identified 1,630 hip fracture incident cases. Among men, consumption of vegetables was associated with lower hip fracture risk. Similarly, dietary total carotenoids and specific carotenoids, α-, β-carotene and lutein/zeaxanthin were inversely associated with hip fracture risk. Compared to men in the lowest quartile of nutrient density, men in the highest quartile had statistically significant 26% to 39% risk reduction ... There was no association between dietary carotenoids or vegetables/fruits and hip fracture risk among women. This study suggests that adequate intake of vegetables may reduce risk of osteoporotic fractures among elderly men and that the antioxidant effects of carotenoids may counteract the mechanism of osteoporosis related to leanness" - See Jarrow Formulas, CarotenALL at Amazon.com.
  • Could a Diet High in Fish and Flax Help Prevent Broken Hips? - Science Daily, 6/27/13 - "The study showed that higher levels of omega-3 fatty acids from both plant and fish sources in those blood cells were associated with a lower likelihood of having fractured a hip ... The study also showed that as the ratio of omega-6 fatty acids to omega-3s increased, so did the risk for hip fracture ... Inflammation is associated with an increased risk of bone loss and fractures, and omega-3 fatty acids are believed to reduce inflammation ... omega-3 fatty acids have anti-inflammatory properties and omega-6 fatty acids seem to have both anti- and pro-inflammatory effects ... women who had the highest ratio of omega-6 to omega-3 fatty acids had nearly twice the risk of hip fractures compared to women with the lowest ratios. The current typical American diet contains between 15 and 17 times more omega-6 than omega-3, a ratio that previous research has suggested should be lowered to 4-to-1, or even 2-to-1, by increasing omega-3s, to improve overall health. The primary omega-6 fatty acid in the diet is linoleic acid, which composes about 99 percent of Americans' omega-6 intake and is found in corn, soybean, safflower and sunflower oils" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
  • Low serum levels of 25-hydroxyvitamin D predict hip fracture in the elderly. A NOREPOS study - J Clin Endocrinol Metab. 2013 May 15 - "risk of hip fracture in Norway, a high-latitude country that has among the highest hip fracture rates worldwide ... We observed an inverse association between s-25(OH)D and hip fracture; those with s-25(OH)D in the lowest quartile (<42.2 nmol/l) had a 38% (95% CI 9-74%) increased risk of hip fracture compared with the highest quartile ... In this prospective case-cohort study of hip fractures, the largest ever reported, we found an increased risk of hip fracture in subjects in the lowest compared to the highest quartile of serum 25-hydroxyvitamin D" - See vitamin D at Amazon.com.
  • Hip bone loss is attenuated with 1000 IU but not 400 IU daily vitamin D3: a 1 year double-blind RCT in postmenopausal women - J Bone Miner Res. 2013 Apr 13 - "Caucasian women aged 60-70 y (n = 305) were randomized to one of two doses of vitamin D or placebo ... Mean BMD loss at the hip was significantly less for the 1000 IU vitamin D group (0.05 +/- 1.46%), compared to the 400 IU vitamin D or placebo groups (0.57 +/- 1.33% and 0.60 +/- 1.67%, respectively) (p < 0.05). Mean(+/- SD) baseline 25(OH)D was 33.8 +/- 14.6 nmol/L; comparative 25(OH)D change for the placebo, 400 IU and 1000 IU vitamin D groups was: -4.1 +/- 11.5 nmol/L, +31. 6 +/- 19.8 nmol/L and +42.6 +/- 18.9 nmol/L respectively" - See vitamin D at Amazon.com.
  • Dietary patterns and the risk of hip fractures in elderly Chinese: A matched case-control study - J Clin Endocrinol Metab. 2013 Apr 12 - "Face-to-face interviews were conducted to assess dietary intake using a 79-item food frequency questionnaire ... We identified four dietary patterns: healthy, prudent, traditional, and high fat. Dose-dependent lower risks of hip fracture were observed in relation to higher scores in the healthy dietary pattern related to high fruit and vegetable intake, and in the prudent pattern typified by a higher intake of nuts, mushrooms, algae, and seafood but lower in grains, whereas the same were associated with lower scores in the high fat dietary pattern (all P trend <0.05). The adjusted ORs (95% CIs) for hip fractures, comparing the extreme tertiles of the three patterns, were 0.42 (0.24-0.73) for healthy, 0.51 (0.28-0.90) for prudent, and 2.25 (1.38-3.69) for high fat"
  • Cartenoids found to reduce hip fracture risk in lean men - Science Daily, 12/16/12 - "Elderly who are lean (BMI <20 kg/m2) are at higher risk of hip fracture compared to those with higher BMI ... researchers examined the association between dietary antioxidant carotenoids and hip fracture risk across a range of BMI in elderly Chinese men and women using data from the Singapore Chinese Health Study ... low BMI is a stronger risk factor for hip fracture risk among elderly men compared to women ... Also, in men, hip fracture risk decreased with increasing intakes of total vegetables and of total carotenoids, particularly β-carotene" - See Jarrow Formulas, CarotenALL at Amazon.com.
  • High physical fitness in young adulthood reduces the risk of fractures later in life in men: A nationwide cohort study - J Bone Miner Res. 2012 Nov 26 - "Aerobic capacity and isometric muscle strength were measured in 435445 Swedish men that conscripted for military service from 1969-1978 ... When comparing men in the lowest and highest decile of physical fitness, the risk of a fracture was 1.8 times higher (95% CI = 1.6-2.1) and that of hip fracture was 2.7 times higher (95% CI = 1.6-4.7). The risk of fracture was also 1.4-1.5 times higher when comparing the extreme deciles of muscle strength (p < 0.001 for all). In a subcohort of 1009 twin pairs, up to 22% of the variation in physical fitness and 27-39% of the variation in muscle strength was attributable to environmental factors unique to one twin, e.g. physical activity. In conclusion, low aerobic capacity and muscle strength in young adulthood are associated with an increased risk of low-energy fractures later in life, while a low-energy fracture is associated with an increased risk of death already in middle-aged men"
  • Joint failures potentially linked to oral bacteria - Science Daily, 4/18/12 - "The culprit behind a failed hip or knee replacements might be found in the mouth. DNA testing of bacteria from the fluid that lubricates hip and knee joints had bacteria with the same DNA as the plaque from patients with gum disease and in need of a joint replacement ... it might be the reason why aseptic loosening or prosthetic wear of the artificial joints fail within 10 years when no infection appears to be present ... For a long time, we've suspected that these bacteria were causing problems in arthritis patients, but never had the scientific evidence to support it" - See Xlear Spry Peppermint Gum, 600-Count (Made with 100% xylitol) at Amazon.com.
  • A Randomized Controlled Trial of Vitamin D Dosing Strategies After Acute Hip Fracture - Medscape, 9/12/11 - "Our findings reveal that a simple daily 1,000 IU vitamin D3 dosing regimen may be as effective as a regimen that adds a loading dose of vitamin D2 to daily vitamin D3 for increasing 25-OHD levels as early as 4-weeks. However, more than 25% of all study patients taking 1,000 IU vitamin D3 (with or without the loading dose) still did not achieve the target 25-OHD level of at least 75 nmol/L. Future studies should examine higher daily doses of vitamin D3 (i.e. 2,000 IU) as well as the benefits of an additional loading dose in patients who are severely deficient" - See vitamin D at Amazon.com.
  • Before you start bone-building meds, try dietary calcium and supplements, experts urge - Science Daily, 5/2/11 - "For many people, prescription bone-building medicines should be a last resort ... adults who increase their intake of calcium and vitamin D usually increase bone mineral density and reduce the risk for hip fracture significantly ... I suspect that many doctors reach for their prescription pads because they believe it's unlikely that people will change their diets ... prescription bone-building medications are expensive, and many have side effects, including ironically an increase in hip fractures and jaw necrosis. They should be used only if diet and supplements don't do the trick ... For bone health, the researchers also encourage consuming adequate protein, less sodium, and more magnesium and potassium"
  • Dietary Intakes of Arachidonic Acid and {alpha}-Linolenic Acid Are Associated with Reduced Risk of Hip Fracture in Older Adults - J Nutr. 2011 Apr 20 - "arachidonic acid (AA) ... Participants in the highest quartile of ALA intake had a 54% lower risk of hip fracture than those in the lowest quartile (Q4 vs. Q1: HR = 0.46; 95% CI = 0.26-0.83). Men in the highest quartile of AA intake had an 80% lower risk of hip fracture than those in the lowest quartile (Q4 vs. Q1: HR = 0.20; 95% CI = 0.04-0.96). No significant associations were observed among intakes of EPA, DHA, EPA+DHA, or fish. These findings suggest dietary ALA may reduce hip fracture risk in women and men and dietary AA may reduce hip fracture risk in men" - See alpha lipoic acid products at Amazon.com. Note that arachidonic acid is in the omega-6 category.
    • Arachidonic acid - Wikipedia - "Arachidonic acid in the human body usually comes from dietary animal sources—meat, eggs, dairy—or is synthesized from linoleic acid"
  • Three-quarters of hip fracture patients are vitamin D deficient, Indian study reveals - Science Daily, 12/12/10 - "Of the patients who had suffered hip fractures, 76.7% were shown to be vitamin D deficient as measured by serum 25(OH)D levels of less than 20 ng/ml" - See vitamin D at Amazon.com.
  • Vitamin D Treatment for the Prevention of Falls in Older Adults - Medscape, 9/30/10 - "In summary, vitamin D supplementation is an effective strategy for reducing falls in older adults and should probably be incorporated into the clinical practice of providers caring for older adults, especially those at risk for falling. Although the effect appears to be modest, possibly because of inadequate dosing, vitamin D is inexpensive and well tolerated; a slight reduction in falls with vitamin D supplementation might lead to a significant decrease in the costs associated with fall morbidity and mortality" - See vitamin D at Amazon.com.
  • Dietary protein may reduce hip fractures in the elderly - Science Daily, 5/5/10 - "individuals who were in the lowest 25 percent of dietary protein intake had approximately 50 percent more hip fractures than those who consumed greater amounts of dietary protein (all within normal intakes). Those who suffered hip fractures consumed less than the 46 grams of dietary protein per day recommended for adults"
  • Vitamin D May Help Prevent Falls - WebMD, 10/2/09 - "Taking vitamin D supplements, at a dose of 700-1,000 international units per day, may make falling 19% less likely for people aged 65 and older" - See vitamin D at Amazon.com.
  • High-Dose Vitamin D Supplement May Reduce Risk of Falling Among Older People - Medscape, 10/1/09 - "Supplemental vitamin D in a dose of 700-1000 IU a day reduced the risk of falling among older individuals by 19% and to a similar degree as active forms of vitamin D" - See vitamin D at Amazon.com.
  • Carotenoids linked to fewer hip fractures - Nutra USA, 3/26/09 - "higher lycopene intake was associated with a lower risk of hip fracture, and non-vertebral fracture ... a weak but statistically un-significant protective trend was recorded total beta-carotene, but only for hip fractures ... No protective effects were observed for the other carotenoids" - [Abstract] - See lycopene at Amazon.com.
  • Protective Effect of Total Carotenoid and Lycopene Intake on the Risk of Hip Fracture: A 17-Year Follow-Up From the Framingham Osteoporosis Study - J Bone Miner Res. 2009 Jan 12 - "Subjects with higher lycopene intake had lower risk of hip fracture (P trend=0.01), and non-vertebral fracture (P trend=0.02). A weak protective trend was observed for total beta-carotene for hip fracture alone but associations did not reach statistical significance (P trend=0.10). No significant associations were observed with alpha-carotene, beta-cryptoxanthin or lutein plus zeaxanthin. These results suggest a protective role of several carotenoids for bone health in older adults" - See lycopene at Amazon.com.
  • Vitamin D Supplements Associated With Reduced Fracture Risk in Older Adults - Doctor's Guide, 3/23/09 - "The authors then pooled the results of only the 9 trials in which participants received doses of more than 400 international units per day. At this dosage, vitamin D supplements reduced non-vertebral fractures by 20% and hip fractures by 18% ... A greater reduction in risk was also seen among trial participants whose blood levels of 25-hydroxyvitamin D achieved a greater increase" - [Science Daily] - See vitamin D at Amazon.com.
  • Tea Drinking May Help Preserve Hip Structure in Elderly Women - Medscape, 10/29/08 - "The cross-sectional analysis revealed that mean total hip aBMD was 2.8% greater in tea drinkers ... Compared with non–tea drinkers, tea drinkers had a significantly higher aBMD at the total hip and trochanter sites but not at the femoral neck and intertrochanter sites" - See green tea extract at Amazon.com.
  • Vitamin C Intake May Reduce Fracture Risk - Medscape, 9/15/08 - "Basically, people who had higher levels of vitamin C intake had half the rate of hip fractures as people who had the lowest vitamin C [levels]"
  • Vitamin D deficiency increases hip fracture risk: researchers - Nutra USA, 8/20/08 - "women with the lowest 25(OH) vitamin D concentrations (47.6 nmol/L) at study entry had a significantly greater increased risk for subsequent hip fracture during the next seven years than did women with the highest concentrations (70.7 nmol/L)" - [Abstract] - See vitamin D at Amazon.com.
  • Serum 25-hydroxyvitamin D concentrations and risk for hip fractures - Ann Intern Med. 2008 Aug 19;149(4):242-50 - "Low serum 25(OH) vitamin D concentrations are associated with a higher risk for hip fracture" - [Nutra USA] - See vitamin D at Amazon.com.
  • Low Vitamin D Linked To Higher Risk Of Hip Fracture - Science Daily, 9/20/07 - "The risk of hip fractures was 77 percent higher among women whose 25 hydroxyvitamin D levels were at the lowest concentrations ... most experts think that people need at least 800 to 1,000 international units a day" - See vitamin D at Amazon.com.
  • Physical Fitness More Important Than Nutrition to Prevent Hip Fracture - Medscape, 9/27/05 - "women who lacked mobility and strength were more apt to fall and fracture their hips"
  • Folate and Vitamin B12 Prevent Hip Fracture in Stroke Patients - Medscape, 3/25/05 - "The magnitude of benefit is similar to that found in trials of alendronate and raloxifene, with considerably less potential risk. The fact that BMD did not change suggests the benefit derives from quality, rather than quantity, of bone"
  • Folic Acid and Vitamin B12 Decrease Risk of Hip Fracture in Stroke Patients - Doctor's Guide, 3/1/05 - "Patients who took folic acid and vitamin B12 after their stroke had a reduced risk of hip fracture compared to patients who took placebo"
  • Vitamin A Levels Affect Hip Fracture Risk - Physician's Weekly, 10/4/04 - "women with the lowest concentrations of vitamin A had a 90% higher risk of hip fracture. Those with the highest concentrations were twice as likely as those with normal levels to sustain a hip fracture"
  • Carpeted Wood Floors Reduce Hip Fracture Risk - WebMD, 4/30/04
  • Vitamin D and Calcium Increase Bone Density and Reduce Falls After Hip Fracture - Healthwell Exchange Daily News, 2/19/04
  • Hoping to Avoid Hip Replacement? - Dr. Weil, 12/4/03
  • Prevalence of hypovitaminosis D in elderly women in Italy: clinical consequences and risk factors - Osteoporos Int. 2003 Jul 11 - "Vitamin D deficiency is extremely common among elderly Italian women ... Hypovitaminosis D is associated with worsening of the ability to perform activities of daily living and higher hip fracture prevalence. This finding should lead to an urgent population-based strategy to remedy this condition"

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