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On 12/4/07 at 11:30 PM on HDNet (HD TV) there was a segment on medications made in India hosted by Dan Rather. In 1972 India passed a law basically making all medications in India generic (no patent). However, in 2005 they changed the law in order to join the World Trade Organization. The way I understand it, all patents after 2005 will be honored by India. The HDNet segment claimed that the generic medications in India had to pass the same inspections as medications manufactured in the US. They noted an AIDS drug that went for $77 per year in India but sold for $10,000 per year in the US. I've been taking a quarter tablet of letrozole from OffshoreRx1.com in India to prevent aromatization. It's still being sold as generic and I've never given quality a second thought. Recent Longevity News for the seven days ending 12/12/07. You should consult your doctor if you are taking any medications. Another Study Finds Heart Risks in a Diabetes Drug - New York Times, 12/11/07 - "Avandia users had a 60 percent increased risk of heart failure, a 40 percent increased risk of heart attacks and a 30 percent increased risk of death, compared with patients taking other oral diabetes medicines" Waist, Hips May Predict Heart Disease - WebMD, 12/10/07 - "a big waist with comparably big hips does not appear to be as worrisome as a big waist with small hips" Elevated Insulin, Glucose Raise Risk of Polyp Recurrence - Medscape, 12/10/07 - "patients with elevated insulin or glucose at the time of adenoma removal are at increased risk for recurrent adenoma ... Levels of glucose that produced the increased risk in this study were actually not very high, 99 mg/dL, which is right at the border of what we would describe as impaired fasting glucose ... the odds ratio for a recurrent polyp with advanced histology or large size was 2.43 at a fasting glucose level above 99 mg/dL ... These results "fit with the theory that insulin resistance, hyperinsulinemia, and hyperglycemia promote the development of colorectal neoplasia,"" Black Raspberries and Esophageal Cancer - Medscape, 12/10/07 - "Most important, 8-epiprostaglandin F2α (8-isoprostane) declined significantly after berry consumption (P < .05), with dramatic individual level declines occurring in 58% of the study patients" - See raspberry extracts at iHerb. Eating More Red And Processed Meats Linked To Greater Risk For Bowel And Lung Cancer, Findings Suggest - Medscape, 12/10/07 - "people who eat a lot of red and processed meats have greater risk of developing colorectal and lung cancer than people who eat small quantities. They also indicate that a high red meat intake is associated with an increased risk of esophageal and liver cancer and that 1 in 10 colorectal and 1 in 10 lung cancers could be avoided if people reduced their red and processed meat intake to the lowest quintile"
Green
Tea Shown To Possess Antitumor Effect In Breast Cancer - Science Daily,
12/8/07 - "green tea
has antitumor effect in breast cancer cells ...
Dr. Maheshwari’s study observed that green tea can inhibit the invading capacity
of these breast cancer cells and have also identified the mechanisms involved in
death inducing and invasion inhibiting effects of green tea" - See
green tea extract at Amazon.com Patients With Mild Cushing Syndrome May Benefit From Adrenalectomy - Science Daily, 12/8/07 - "Diabetes and hypertension improved considerably in most affected patients after adrenalectomy. In addition, all eight patients who reported easy bruising before surgery noted resolution of the problem, and seven of the nine patients lost weight. Fat accumulation around the neck disappeared and muscle weakness improved, often markedly ... patients with subclinical Cushing syndrome rarely have enough cortisol in their urine to raise concern ... The cutoff values are intentionally set high so that we minimize the false positives" - Also see my cortisol page. Sugar and Alzheimer's: Are They Linked? - WebMD, 12/7/07 - "The brains of the sugar-fed mice had about twice as many plaque deposits as the mice fed regular water" - [Science Daily] Diabetes May Increase Woman's Risk of Colorectal Cancer - oncologystat.com, 12/7/07 - "There was about a 50% increased risk of colorectal cancer in women with diabetes ... The researchers hypothesized that the elevated levels of insulin typically seen in people with type 2 diabetes may play a central role. Insulin stimulates the growth of normal colonic and carcinoma cells"
Folate may reduce depression symptoms for men, says study - Nutra USA,
12/7/07 - "male subjects with the highest average intake
(235 micrograms per 100 kcal) were 50 per cent less likely to have depressive
symptoms than men with the lowest average intake (119 micrograms per 100 kcal)"
- [Abstract]
- See
folic acid at Amazon.com Is There an Anticancer Diet? - WebMD, 12/6/07 - "Raw cruciferous vegetables such as broccoli, broccoli sprouts, cabbage, and cauliflower seem to reduce bladder cancer risk by about 40%"
Chemoprevention, Naturally: Findings On Plant-derived Cancer Medicines -
Science Daily, 12/6/07 - "rats fed a diet containing
Polyphenon E, a standardized green tea
polyphenol preparation, are less than half as likely to develop
colon cancer ... After 34 weeks, rats that
received Polyphenon E developed 55 percent fewer tumors compared to the control
rats that did not receive Polyphenon E. Moreover, the tumors were 45 percent
smaller in rats treated with green tea extract" - See
green tea extract at Amazon.com
Vitamin D Deficiency Highly Prevalent Among Epilepsy Patients - Medscape,
12/6/07 - "the study showed 44.5% of
epilepsy patients — 45.3% of men and 43.7% of
women — were vitamin D deficient, putting these
patients at potential increased risk for a wide variety of conditions, including
osteoporosis, autoimmune disease, cancer, cardiovascular disease, and infectious
disease, among others" - See
vitamin D at Amazon.com The Cataracts Are Gone—and So Is the Need for Glasses - US News and World Report, 12/5/07 - "Unlike the standard single-power lenses doctors have been implanting for 30 years, the newer multifocal intraocular lenses and accommodating lenses allow patients to see near, far, and in between—and even to shed their glasses"
Herbal
Extract Found To Increase Lifespan - Science Daily, 12/5/07 -
"Flies that ate a diet rich with
Rhodiola rosea, an herbal supplement long
used for its purported stress-relief effects, lived on an average of 10 percent
longer than fly groups that didn’t eat the herb ... Although this study does not
present clinical evidence that Rhodiola can extend human life, the finding that
it does extend the lifespan of a model organism, combined with its known health
benefits in humans, make this herb a promising candidate for further anti-aging
research ... Rhodiola rosea ... has been used by Scandinavians and Russians for
centuries for its anti-stress qualities ... patients taking a Rhodiola extract
called SHR-5 reported fewer symptoms of depression than did those who took a
placebo" - See
Rhodiola rosea at Amazon.com Mental Health Treatment Extends Lives Of Older Patients With Diabetes And Depression - Science Daily, 12/5/07 - "Researchers at the University of Pennsylvania School of Medicine report that older adults with diabetes and depression are half as likely to die over a 5-year period when they receive depression care management than depressed patients with diabetes who do not receive depression care management" Vinegar at Bedtime Moderates Waking Glucose Level in Type 2 Diabetics - Medscape, 12/4/07 - "The investigators report that the vinegar treatment was especially effective for subjects with a typical fasting glucose greater than 7.2 mmol/L (n = 6). Fasting glucose in these participants was reduced 6% compared with a reduction of 0.7% in those with a typical fasting glucose less than 7.2 mmol/L" - See Source Naturals, Apple Cider Vinegar. 1 Source Natural 500 mg tablet equals 2 tsb of vinegar. 4.5 tablets equals about 3 tablespoons by my calculations.
Fit Beats Fat for a Longer Life - WebMD, 12/4/07 - "Fitness was found to be a strong predictor of longevity in the study, which involved adults ages 60 and older, while obesity had little influence on death risk" Abstracts from this week's Doctor's Guide Nutrition/Dietetics plus abstracts from my RSS feeds (Click here for the journals, the Medline ones at the top): Childhood dairy intake and adult cancer risk: 65-y follow-up of the Boyd Orr cohort - Am J Clin Nutr. 2007 Dec;86(6):1722-9 - "High childhood total dairy intake was associated with a near-tripling in the odds of colorectal cancer [multivariate odds ratio: 2.90 (95% CI: 1.26, 6.65); 2-sided P for trend = 0.005] compared with low intake, independent of meat, fruit, and vegetable intakes and socioeconomic indicators" Dietary fiber intake and retinal vascular caliber in the Atherosclerosis Risk in Communities Study - Am J Clin Nutr. 2007 Dec;86(6):1626-1632 - "Dietary fiber was related to wider retinal arteriolar caliber and narrower venular caliber, which are associated with a lower risk of cardiovascular disease. These data add to the growing evidence of the benefits of fiber intake on various aspects of cardiovascular pathogenesis"
L-Carnitine treatment reduces severity of physical and mental fatigue and
increases cognitive functions in centenarians: a randomized and controlled
clinical trial - Am J Clin Nutr. 2007 Dec;86(6):1738-44 -
"Our study indicates that oral administration of
levocarnitine produces a reduction of total
fat mass, increases total muscular mass, and facilitates an increased capacity
for physical and cognitive activity by reducing fatigue and improving cognitive
functions" - See
l-carnitine at Amazon.com Vitamin B6 treatment for tardive dyskinesia: a randomized, double-blind, placebo-controlled, crossover study - J Clin Psychiatry. 2007 Nov;68(11):1648-54 - "The mean decrease in ESRS clinical global impression scores from baseline to endpoint was 2.4 points in patients treated with vitamin B(6) and 0.2 points in patients treated with placebo (p < .0001). The mean decrease in the parkinsonism subscale score was 18.5 points and 1.4 points, respectively (p < .00001), and the mean decrease in the dyskinesia subscale score was 5.2 points and -0.8 points, respectively ... Vitamin B(6) appears to be effective in reducing symptoms of TD. The specific mechanisms by which vitamin B(6) attenuates symptoms of TD are not clear" Soy isoflavone intake increases bone mineral density in the spine of menopausal women: Meta-analysis of randomized controlled trials - Clin Nutr. 2007 Dec 4 - "Isoflavone intervention significantly attenuates bone loss of the spine in menopausal women. These favorable effects become more significant when more than 90mg/day of isoflavones are consumed. And soy isoflavone consumption for 6 months can be enough to exert beneficial effects on bone in menopausal women" Coffee consumption and mortality in a 14-year follow-up of an elderly northern Finnish population - Br J Nutr. 2007 Dec 6;:1-8 - "The total mortality rate was inversely related to the number of cups (average volume, 125 ml) of coffee consumed daily. After adjustment for age, sub-period of follow-up, sex, marital status, basic educational level, previous occupational group, current smoking, BMI, history of myocardial infarction, self-rated health and presence of diabetes, cognitive impairment or physical disability, the estimated relative risk reduction of total mortality per an increment of one more cup of coffee per d reported at baseline was 4 (95 % CI 0, 8) % ... The present study provides evidence for daily (caffeine-containing) coffee intake being inversely associated with mortality in the elderly"
Association of folate intake with the occurrence of depressive episodes in
middle-aged French men and women - Br J Nutr. 2007 Dec 6;:1-5 -
"the risk of experiencing recurrent
depressive episodes (two or more) during the
follow-up was strongly reduced in men with high
folate intake (OR 0.25 (95 % CI 0.06, 0.98) for the highest tertile v. the
lowest" - See
folic acid at Amazon.com
Dietary lipoic acid-dependent changes in the activity and mRNA levels of hepatic
lipogenic enzymes in rats - Br J Nutr. 2007 Dec 7;:1-9 -
"Lipoic acid profoundly
decreased serum and liver concentrations of TAG, and also lowered serum
concentrations of phospholipid and NEFA, and the concentration of cholesterol in
the liver. A hypoglycaemic effect of this compound was also observed. Lipoic
acid dose-dependently decreased the activity and mRNA levels of fatty acid
synthase, ATP-citrate lyase, glucose 6-phosphate dehydrogenase, malic enzyme and
pyruvate kinase in the liver despite that reductions were considerably
attenuated in the NADPH-producing enzymes. This compound also dose-dependently
lowered the mRNA levels of spot 14, adiponutrin, stearoyl-CoA desaturase 1, and
Delta5- and Delta6-desaturases. In addition, lipoic acid dose-dependently
lowered serum concentrations of insulin and leptin, but increased those of
adiponectin. Lipoic acid appeared to reduce
hepatic lipogenesis and hence decreases serum and liver lipid levels.
Alterations in serum concentrations of insulin and (or)
adiponectin may trigger this consequence"
- See
alpha lipoic acid at Amazon.com
Dietary intake of folate, other B vitamins, and omega-3 polyunsaturated fatty
acids in relation to depressive symptoms in Japanese adults - Nutrition.
2007 Nov 29 - "The multivariate odds ratios (95%
confidence intervals) for depressive symptoms for men in the first, second,
third, and fourth quartiles of folate intake were 1.00 (reference), 0.78
(0.38-1.63), 0.57 (0.27-1.18), and 0.50 (0.23-1.06), respectively" - See
folic acid at Amazon.com Effects of green tea on insulin sensitivity, lipid profile and expression of PPARalpha and PPARgamma and their target genes in obese dogs - Br J Nutr. 2007 Dec 6;:1-9 - "At 12 weeks in the green tea group, mean insulin sensitivity index was 60 (sem 11) % higher (P < 0.05) and TAG concentration 50 (sem 10) % lower (P < 0.001), than baseline ... These findings show that nutritional doses of green tea extract may improve insulin sensitivity and lipid profile and alter the expression of genes involved in glucose and lipid homeostasis" Effect of the Angiotensin Receptor Blocker Irbesartan on Metabolic Parameters in Clinical Practice: the DO-IT Prospective Observational Study - Cardiovasc Diabetol. 2007 Nov 27;6(1):36 - "Six months of irbesartan therapy decreased systolic blood pressure by 14% (157.4+/-14.7 vs. 135.0+/-10.7 mmHg) and diastolic blood pressure by 13% (92.9+/-9.2 vs. 80.8+/-6.8 mmHg). This was associated with a decrease in body weight (-2.3%), fasting glucose (-9.5%), HbA1c (-4.6%), LDL-cholesterol (-11%), triglycerides (-16%) and gamma-GT (-12%) and an increase in HDL-cholesterol (+5%)" Effects of androgen deprivation on glycaemic control and on cardiovascular biochemical risk factors in men with advanced prostate cancer with diabetes - Aging Male. 2007 Dec;10(4):189-96 - "In men with insulin-dependent diabetes, androgen deprivation therapy may have negative effects on their glycaemic control and may aggravate the biochemical risk profile of cardiovascular disease to which diabetics are predisposed. These observations are in agreement with the emerging role of low levels of testosterone in metabolic syndrome and insulin resistance" Erectile dysfunction is associated with low bioactive testosterone levels and visceral adiposity in men with type 2 diabetes - Int J Androl. 2007 Nov;30(6):500-7 - "ED is associated with low bioavailable and free testosterone levels, age, visceral adiposity and hypertension in type 2 diabetic men" Testosterone, diabetes mellitus, and the metabolic syndrome - Curr Urol Rep. 2007 Nov;8(6):467-71 - "One third of men with type 2 diabetes mellitus are now recognized as testosterone deficient. Emerging evidence suggests that testosterone therapy may be able to reverse some aspects of metabolic syndrome"
Guanidino Compounds After Creatine Supplementation in Renal Failure Patients and
their Relation to Inflammatory Status - Nephrol Dial Transplant. 2007 Nov 29
- "Specific guanidino compounds have been described as
uraemic toxins and their concentrations are increased in
renal failure due to dimished glomerular
filtration, whereas the guanidino compound creatine
is used as a performance-enhancing substance in athletes. The present study
investigates the effects of creatine supplementation on plasma guanidino
compounds in a chronic haemodialysis population ... Patients were treated with
creatine (2 g/day) or placebo during two treatment periods of 4 weeks ... Upon
creatine supplementation, guanidinoacetate concentrations decreased by 15%, due
to inhibition of creatine synthesis. Concentrations of
alpha-keto-delta-guanidinovaleric acid increased three-fold and argininic acid
concentrations doubled" - See
creatine at Amazon.com Renoprotective effect of the addition of losartan to ongoing treatment with an Angiotensin converting enzyme inhibitor in type-2 diabetic patients with nephropathy - Hypertens Res. 2007 Oct;30(10):929-35 - "During the 12-month treatment, addition of losartan or addition of an ACE-I to the treatment protocol reduced systolic blood pressure (SBP) by 10% and 12%, diastolic blood pressure (DBP) by 7% and 4%, and urinary albumin excretion by 38% and 20% of the baseline value, respectively. However, the effects on both BP and urinary albumin were not significantly different between the two therapies. In conclusion, addition of losartan or an ACE-I to an ongoing treatment with an ACE-I, or addition of an ACE-I to ongoing treatment with a conventional antihypertensive were equally effective at reducing the urinary albumin excretion and BP, and provided renal protection in patients with type-2 diabetic nephropathy" Supplement Focus (Alpha Lipoic Acid):
Abstracts:
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