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Recent Longevity News for the seven days ending 12/22/10.  You should consult your doctor if you are taking any medications.

Component in common dairy foods may cut diabetes risk, study suggests - Science Daily, 12/20/10 - "The compound, trans-palmitoleic acid, is a fatty acid found in milk, cheese, yogurt, and butter ... trans-palmitoleic acid may underlie epidemiological evidence in recent years that diets rich in dairy foods are linked to lower risk of type 2 diabetes and related metabolic abnormalities. Health experts generally advise reducing full-fat dairy products, but trans-palmitoleic acid is found in dairy fat ... At baseline, higher circulating levels of trans-palmitoleic acid were associated with healthier levels of blood cholesterol, inflammatory markers, insulin levels, and insulin sensitivity, after adjustment for other risk factors. During follow-up, individuals with higher circulating levels of trans-palmitoleic acid had a much lower risk of developing diabetes, with about a 60% lower risk among participants in the highest quintile (fifth) of trans-palmitoleic acid levels" - So maybe I can stop feeling guilty about my yoghurt made with 50% full fat powdered milk and 50% skim powdered milk.  I eat a lot of it.  My triglycerides on the last test were 91 and my fasting glucose 83.  Yoghurt is about as low as you can get with 10 AGEs/serving (kU) compared to broccoli at 226 or broiled franks at 10,143.  Click here for the table.

Boosting supply of key brain chemical reduces fatigue in mice - Science Daily, 12/20/10 - "Researchers at Vanderbilt University have "engineered" a mouse that can run on a treadmill twice as long as a normal mouse by increasing its supply of acetylcholine ... could lead to new treatments for neuromuscular disorders such as myasthenia gravis, which occurs when cholinergic nerve signals fail to reach the muscles ... The choline transporter is vital to the capacity for muscle contraction -- including the ability to breathe -- because it regulates the supply of choline, the precursor to acetylcholine. "We reasoned that giving more of this protein might enhance muscle function and reduce nerve-dependent fatigue,"" - See citicholine at Amazon.com.

'Love hormone' may treat daily headaches - MSNBC, 12/20/10 - "Of patients given a dose of oxytocin as a nasal spray, 50 percent reported their headache pain was reduced by half, and an additional 27 percent of these patients reported no pain after four hours. By comparison, 11 percent of patients who were given a placebo spray said their headache pain was cut by half after four hours, and none reported complete pain relief" - See Oxytocin 6x5iu tablets at International Antiaging Systems.

Squeezing maximum health benefits out of the orange in your stocking - Science Daily, 12/20/10 - "We're looking for synergistic effects ... Cases where the effect of two or more antioxidants together was stronger than the sum of them separately ... In conclusion, they identified several combinations of antioxidants that were the most synergistic -- the compounds hesperidin and naringenin, in particular, appeared to contribute the most punch in the combinations" - Note:  I started a web page on synergy years ago.  The links went dead and I removed most of them.  There hasn't been any news on it in the last several years.  It's been the philosophy in my own regiment for years (taking small amounts of several supplements instead of mega doses of any one) plus if they find a negative effect on and one supplement you've only bee taking a small amount instead of mega doses.

Orange juice flavanone may benefit heart health: Study - Nutra USA, 12/17/10 - "The researchers reported that blood pressure was significantly lowered after 4 weeks consumption of orange juice or a hesperidin rich drink when compared to a placebo drink" - [Abstract] - See hesperidin at Amazon.com.

Double Espresso vs Prostate Cancer - Medscape, 12/17/10 - "This wasn't a randomized trial. It was epidemiologic observational research. What they did was they gave people a questionnaire about their coffee drinking habits, and then they correlated that with hospital records on who got advanced prostate cancer and who didn't. Of course, there's a big problem with doing that type of research, which is that people who drink coffee may be different from people who don't drink coffee in all sorts of ways other than their caffeine consumption. Here's the number-one reason I don't actually believe the study. What the investigators reported was a 60% decrease in your risk for advanced prostate cancer if you drank coffee. Finasteride and dutasteride, these are drugs that we know in randomized trials are effective for prostate cancer, and we know that they have a mechanism of action that is pertinent to the prostate. Those 2 drugs reduce the risk for cancer by about 25%. Nothing is going to reduce the risk for advanced prostate cancer by 60%. I doubt if chemotherapy would. This is just a guess, little indication that the results of the study are due to bias ... There's another problem with these sorts of studies. Cancer takes a long time to develop. In fact, in the case of prostate cancer, we know that it takes 30 or more years between initiation of cancer and a clinical diagnosis"

PSA test better predicts cancer in men taking prostate-shrinking drug - Science Daily, 12/16/10 - "Dutasteride lowers PSA levels by about half within six months. But the researchers found that even a slight rise in PSA levels among men taking the drug was a stronger indicator of prostate cancer, particularly aggressive tumors that require early diagnosis and treatment, than rising PSA levels in men who took a placebo ... dutasteride reduced the risk of a prostate cancer diagnosis by 23 percent. Dutasteride appears to keep tumors small or shrink them to the point that they are less likely to be detected by a biopsy ... Over four years, PSA levels increased in 72 percent of men taking a placebo and only 29 percent of men taking dutasteride, the data show" - See dutasteride at OffshoreRx1.com.

Higher HDL-C Levels May Curb Alzheimer's Disease Risk - Medscape, 12/16/10 - "There was a definite threshold effect, the researchers say, with a clear reduction in AD risk for people in the highest HDL-C level quartile (>56 mg/dL) ... these analyses were limited by the small number of cases of vascular dementia (n = 16) ... the current study linking higher HDL-C to a lower risk for incident dementia contrast with a prior study by the same researchers. This earlier study involved 1168 participants recruited from the same community in 1992 – 1994 and showed no association between HDL-C and AD ... Compared with the 1992 – 1994 cohort, the 1999 – 2001 cohort had a higher proportion of subjects receiving lipid-lowering treatment (23.4% vs 14.5%), higher mean HDL-C levels (48.3 vs 47.2 mg/dL), and fewer individuals who smoked (9.4% vs 10.6%) and had heart disease (18.8% vs 34.1%)"

Garlic could protect against hip osteoarthritis - Science Daily, 12/16/10 - "women who consume a diet high in allium vegetables, such as garlic, onions and leeks, have lower levels of hip osteoarthritis ... a compound called diallyl disulphide limits the amount of cartilage-damaging enzymes when introduced to a human cartilage cell-line in the laboratory ... While we don't yet know if eating garlic will lead to high levels of this component in the joint, these findings may point the way towards future treatments and prevention of hip osteoarthritis"

Dannon's Activia, DanActive health claims draw $21M fine - USATODAY.com, 12/15/10 - "Dannon will stop claiming that one daily serving of Activia yogurt relieves irregularity and that DanActive helps people avoid catching colds" - Here's the reason I used Activia to make my own yoghurt (first bullet).  This article doesn't address it.  I never did buy off on the irregularity claim but there might be some support for colds:

  • Dannon Activia | How Activia Helps - Activia.com - "This is where Activia, with Bifidus Regularis®, can help! Activia is shown in several clinical studies to survive passage through the digestive system and arrive in the gut in enough quantities to help have a positive impact on slow intestinal transit"
  • Probiotics show potential against common cold: Study - Nutra USA 9/21/10 - "daily consumption of Lactobacillus plantarum HEAL 9 (DSM 15312) and Lactobacillus paracasei 8700:2 (DSM 13434) reduced the incidence of one or more episodes of the common cold from 67 percent in the placebo group to 55 percent, according to findings published in the European Journal of Nutrition ... Furthermore, the number of days of symptoms for the cold was significantly reduced in people taking the probiotic supplements, from an average of 8.6 to 6.2, compared with placebo ... the total symptom score was reduced during the study period from a mean of 44.4 for the control group to 33.6 for the probiotic group"

Increased BPA exposure linked to reduced egg quality in women - Science Daily, 12/15/10 - "As blood levels of BPA in the women studied doubled, the percentage of eggs that fertilized normally declined by 50 percent ... Given the widespread nature of BPA exposure in the U.S., even a modest effect on reproduction is of substantial concern"

The Benefits of Exercising Before Breakfast - NYTimes.com, 12/15/10 - "One of the groups ate a hefty, carbohydrate-rich breakfast before exercising and continued to ingest carbohydrates, in the form of something like a sports drink, throughout their workouts. The second group worked out without eating first and drank only water during the training. They made up for their abstinence with breakfast later that morning, comparable in calories to the other group’s trencherman portions ... Only the group that exercised before breakfast gained almost no weight and showed no signs of insulin resistance. They also burned the fat they were taking in more efficiently" - That's something  I've been doing since Moby Dick was a minnow.

The key to being attractive (and looking healthy)? A good night's sleep - Science Daily, 12/14/10 - "The observers judged the faces of sleep-deprived participants as less healthy, less attractive and more tired ... The authors conclude that the facial signals of sleep deprived people affect facial appearance and judgments of attractiveness, health and tiredness"

Abstracts from this week's Doctor's Guide Nutrition/Dietetics plus abstracts from my RSS feeds (Click here for the journals, the PubMed ones at the top):

Resveratrol enhances the anti-tumor activity of the mTOR inhibitor rapamycin in multiple breast cancer cell lines mainly by suppressing rapamycin-induced AKT signaling - Cancer Lett. 2010 Dec 16 - "The anti-tumor activity of rapamycin is compromised by the feedback-loop-relevant hyperactive PI3K and ERK-MAPK pathway signaling. In breast cancer cells treated with rapamycin, we observed a moderate increase of AKT phosphorylation (P-AKT) in a rapamycin resistant cell line, MDA-MB-231, as well as a slight increase of P-AKT in a rapamycin sensitive cell line, MCF-7. We found that resveratrol, a natural phytoalexin, suppressed the phosphorylation and activation of the PI3K/AKT pathway in all the three breast cancer cell lines that we tested. It also had a weak inhibitory effect on the activation of the mTOR/p70S6K pathway in two cell lines expressing wildtype PTEN, MCF-7 and MDA-MB-231. The combined use of resveratrol and rapamycin resulted in modest additive inhibitory effects on the growth of breast cancer cells, mainly through suppressing rapamycin-induced AKT activation"

A Heat-Stable Extract From Mucuna Stimulates the Differentiation of Bone Marrow Cells Into Dendritic Cells and Induces Apoptosis in Cancer Cells - Nutr Cancer. 2010 Dec 16:1 - "Pine cone extract is known to induce differentiation of human mononuclear cells into dendritic cells (DCs) and also to induce apoptosis in human cancer cells. In the present study, we screened edible plants that contain components with biological activities similar to or more potent than those of pine cone extract. We found that Mucuna (Mucuna pruviens var. utilis) contains a DC differentiation/maturation-inducing activity and a component that induces apoptosis in human cancer cell lines. Mucuna extract specifically stimulated differentiation of BM cells to immature DCs. Marked production of IL-6 was observed by sequential treatment with at least 10 μg/mL of Mucuna extract followed by LPS. The sequential treatment with Mucuna extract followed by LPS produced a much higher ratio of IL-12 to IL-6 and a lower ratio of TNF-α to IL-6 than that obtained by sequential treatment with a medicinal mushroom Phellinus linteus extract and then LPS. The DC differentiation/maturation activity and the component inducing apoptosis in cancer cells were separable by column chromatography" - See Mucuna pruriens at Amazon.com.

  • Dendritic cell - Wikipedia - "Dendritic cells (DCs) are immune cells that form part of the mammalian immune system. Their main function is to process antigen material and present it on the surface to other cells of the immune system, thus functioning as antigen-presenting cells. They act as messengers between the innate and adaptive immunity"

Chronic intake of red wine polyphenols by young rats prevents aging-induced endothelial dysfunction and decline in physical performance: Role of NADPH oxidase - Biochem Biophys Res Commun. 2010 Dec 15 - "Aging is associated with oxidative stress-mediated endothelial dysfunction and decline in physical performance, which promote cardiovascular diseases. This study examined whether chronic intake of red wine polyphenols (RWPs), a rich source of natural antioxidants, prevents aging-related impairment of vascular function and physical exercise capacity. Vascular reactivity from 12-, 20- and 40-week-old rats was assessed in organ chambers. Rats received from week 16 to 40 either solvent, RWPs or the antioxidant and NADPH oxidase inhibitor, apocynin. Aging was associated with blunted endothelium-dependent relaxations, oxidative stress (dihydroethidine staining), and an upregulation of eNOS, arginase I, NADPH oxidase p22phox and nox1 subunits, and AT1 and AT2 receptors (assessed by immunohistochemistry) in the mesenteric artery. RWPs and apocynin improved the endothelial dysfunction, normalized oxidative stress and the expression of the different proteins. RWPs also improved aging-related decline in physical exercise" - See grape seed extract at Amazon.com.

Dietary patterns and risk of breast cancer - Br J Cancer. 2010 Dec 14 - "only that characterised by high consumption of fruit and salad was associated with a reduced risk, with stronger associations observed for tumours not expressing oestrogen (ER) and progesterone receptors (PR). Compared with women in the lowest quintile of the factor score, the hazard ratio for women in the highest quintile was 0.92 (95% confidence interval (CI)=0.70-1.21; test for trend, P=0.5) for ER-positive or PR-positive tumours and 0.48 (95% CI=0.26-0.86; test for trend, P=0.002) for ER-negative and PR-negative tumours"

'Love hormone' may treat daily headaches - MSNBC, 12/20/10 - "Of patients given a dose of oxytocin as a nasal spray, 50 percent reported their headache pain was reduced by half, and an additional 27 percent of these patients reported no pain after four hours. By comparison, 11 percent of patients who were given a placebo spray said their headache pain was cut by half after four hours, and none reported complete pain relief" - See Oxytocin 6x5iu tablets at International Antiaging Systems.

Protective effect of lycopene on serum cholesterol and blood pressure: Meta-analyses of intervention trials - Maturitas. 2010 Dec 14 - "Lycopene, a carotenoid found in tomatoes ... Meta-analysis of the effect of lycopene on systolic blood pressure of all trials suggested a significant blood pressure reducing effect (mean systolic blood pressure change+/-SE: -5.60+/-5.26mm Hg, p=0.04) ... Our meta-analysis suggests that lycopene taken in doses ≥25mg daily is effective in reducing LDL cholesterol by about 10% which is comparable to the effect of low doses of statins in patient with slightly elevated cholesterol levels" - See Jarrow Lyco-Sorb (contains Lyco-O-Mato) at Amazon.com.

Resveratrol potentiates glucose-stimulated insulin secretion in INS-1E beta-cells and human islets through Sirt1 dependent mechanism - J Biol Chem. 2010 Dec 16 - "Resveratrol, a polyphenol compound, is known for its effects on energy homeostasis. With properties of energy sensors mediating effects of calorie restriction, sirtuins are targets of resveratrol ... Resveratrol markedly enhanced the glucose response of INS-1E cells and human islets, even after removal of the compound from the medium. These effects were mediated by and fully dependent on active Sirt1, defining a new role for Sirt1 in the regulation of insulin secretion" - See resveratrol products at Amazon.com.

Tocotrienols inhibit lipopolysaccharide-induced pro-inflammatory cytokines in macrophages of female mice - Lipids Health Dis. 2010 Dec 16;9(1):143 - "The present results clearly demonstrate that alpha-, gamma-, or delta-tocotrienol treatments inhibit the chymotrypsin-like activity of 20S rabbit muscle proteasomes ... These results represent a novel approach by using natural products, such as tocotrienols as proteasome modulators, which may lead to the development of new dietary supplements of tocotrienols for cardiovascular diseases as well as others that are based on inflammation" - See Jarrow FamilE (contains all eight members of the vitamin E family, includes Tocomin) at Amazon.com.

Citicoline in Vascular Cognitive Impairment and Vascular Dementia After Stroke - Stroke. 2010 Dec 16 - "Stroke doubles the risk of dementia and is a major contributor to vascular cognitive impairment and vascular dementia ... Citicoline has demonstrated neuroprotective effects in acute stroke and has been shown to improve cognition in patients with chronic cerebrovascular disease and in some patients with Alzheimer disease. A recent trial lasting 6 months in patients with first-ever ischemic stroke showed that citicoline prevented cognitive decline after stroke with significant improvement of temporal orientation, attention, and executive function. Experimentally, citicoline exhibits neuroprotective effects and enhances neural repair. Citicoline appears to be a safe and promising alternative to improve stroke recovery and could be indicated in patients with vascular cognitive impairment, vascular dementia, and Alzheimer disease with significant cerebrovascular disease" - See citicholine at Amazon.com.

Neuroprotection and Recovery: Recent Data at the Bench on Citicoline - Stroke. 2010 Dec 16 - "Although the mechanisms of some of these actions remain to be elucidated, so far citicoline appears as a drug with the ability to promote "safe" neuroprotection capable of enhancing endogenous protective pathways at the same time as preparing the scenario for plasticity" - See citicholine at Amazon.com.

The Farther From Town the Lower the Blood Pressure: Report From Rural Yunnan Province - Am J Hypertens. 2010 Dec 16 - "Chinese farmers ... There was a significant (P < 0.001) inverse relationship between BP and distance from populations centers. For every 10 km from the town center, the mean systolic BP (SBP) in the village decreased by 1.2 mm Hg and the mean diastolic by 0.5 mm Hg. After adjustment for age, gender, ethnicity, body mass index, smoking, and drinking, we found that SBP decreased by 1.8 mm Hg (P = 0.03) and diastolic BP by 1.0 mm Hg (P = 0.02) for every 10 km distance from the town center"

Higher Blood Pressure Associated With Higher Cognition and Functionality Among Centenarians in Australia - Am J Hypertens. 2010 Dec 16 - "Average age of participants was 101.1 years. Hypertension was demonstrated in 1% according to the WHO criterion (≥140/90 mm Hg). However, 38% of centenarians were hypertensive, defined as having a medical diagnosis of hypertension, and/or being on antihypertensive medications, and/or having a BP measurement ≥ 140/90 mm Hg. Mean values were: systolic = 130 mm Hg (90-182 mm Hg), diastolic = 70 mm Hg (44-98 mm Hg), and pulse pressure (PP) = 60 mm Hg (20-130 mm Hg). Hypercholesterolaemia was only detected in 8% of participants. Hypertension was not associated with increased risk of hypercholesterolaemia. Low systolic BP (SBP) and narrower PP was associated with lower MMSE scores. High SBP and wider PP was associated with better functional status"

Magnesium supplementation, metabolic and inflammatory markers, and global genomic and proteomic profiling: a randomized, double-blind, controlled, crossover trial in overweight individuals - Am J Clin Nutr. 2010 Dec 15 - "We observed that magnesium treatment significantly decreased fasting C-peptide concentrations (change: -0.4 ng/mL after magnesium treatment compared with +0.05 ng/mL after placebo treatment; P = 0.004) and appeared to decrease fasting insulin concentrations (change: -2.2 μU/mL after magnesium treatment compared with 0.0 μU/mL after placebo treatment; P = 0.25) ... Urine proteomic profiling showed significant differences in the expression amounts of several peptides and proteins after treatment" - See magnesium supplements at Amazon.com.

Dietary omega-3 fatty acid supplementation increases the rate of muscle protein synthesis in older adults: a randomized controlled trial - Am J Clin Nutr. 2010 Dec 15 - "Omega-3 fatty acids stimulate muscle protein synthesis in older adults and may be useful for the prevention and treatment of sarcopenia" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.

Dose-response effects of omega-3 fatty acids on triglycerides, inflammation, and endothelial function in healthy persons with moderate hypertriglyceridemia - Am J Clin Nutr. 2010 Dec 15 - "effects of 0.85 and 3.4 g EPA+DHA/d ... The higher dose of EPA+DHA lowered triglycerides by 27% compared with placebo (173 +/- 17.5 compared with 237 +/- 17.5 mg/dL; P = 0.002), whereas no effect of the lower dose was observed on lipids. No effects on cholesterol (total, LDL, and HDL), endothelial function [as assessed by flow-mediated dilation, peripheral arterial tonometry/EndoPAT (Itamar Medical Ltd, Caesarea, Israel), or Doppler measures of hyperemia], inflammatory markers (interleukin-1β, interleukin-6, tumor necrosis factor-α, and high-sensitivity C-reactive protein), or the expression of inflammatory cytokine genes in isolated lymphocytes were observed" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.

Efficacy and safety of high-dose α-lipoic acid in the treatment of diabetic polyneuropathy - Zhonghua Yi Xue Za Zhi. 2010 Sep;90(35):2473-2476 - "total symptom score (TSS) ... 73.27% patients with symptomatic polyneuropathy improved after treatment with α-lipoic acid for 12 weeks versus 18.27% with placebo. TSS declined by 2.6 +/- 2.3 with α-lipoic acid. And it was more than 0.7 +/- 1.4 versus placebo (P < 0.05). TSS decreased quickly after treatment with α-lipoic acid for 2 weeks (P < 0.05). And it was better than placebo. Individual symptom scores of pain, extremity numbness, burning sensation or resting abnormal sensations were significantly diminished as compared to those before treatment and placebo group (all P < 0.05). Nerve conduction velocity had no change. HbA1c further decreased at the end of trial after α-lipoic acid treatment (P < 0.05). The incidence rates of adverse effects were 25.4% vs 11.8% in the treatment and control groups. The major manifestation was burning sensation from throat to stomach (12.7%)" - See alpha lipoic acid at Amazon.com.

N-acetylcysteine in psychiatry: current therapeutic evidence and potential mechanisms of action - J Psychiatry Neurosci. 2010 Nov 1;35(6):100057 - "This review outlines the current literature regarding the use of NAC in disorders including addiction, compulsive and grooming disorders, schizophrenia and bipolar disorder. N-acetylcysteine has shown promising results in populations with these disorders, including those in whom treatment efficacy has previously been limited. The therapeutic potential of this acetylated amino acid is beginning to emerge in the field of psychiatric research" - See n-acetyl cysteine at Amazon.com.

Epigenetics, an Early Event in the Modulation of Gene Expression by Inositol Hexaphosphate in Ethylnitrosourea Exposed Mouse Lungs - Nutr Cancer. 2010 Dec 13:1-11 - "study indicates the possible role of epigenetics at the early stage of tumor development and in the regulation of gene expression by IP6 before the onset of ENU-induced lung tumors" - See IP-6 products at Amazon.com.

Household contact with pets and birds and risk of lymphoma - Cancer Causes Control. 2010 Dec 14 - "Frequent contact with birds was inversely associated with lymphoma, and particularly B-cell non-Hodgkin lymphoma (odds ratio [OR] = 0.6, 95% confidence interval [95% CI]: 0.4, 0.9). Contact with chickens accounted for this inverse association, which was strongest for first contact occurring at age ≤8 years (OR = 0.4, 95% CI: 0.2, 1.0). No association was observed when first contact occurred at age 9 or older. Contact with any pets was inversely associated with risk of diffuse large B-cell lymphoma (OR = 0.4, 95% CI: 0.2, 1.0), but not other lymphoma subtypes"

The effects of dietary and nutrient interventions on arterial stiffness: a systematic review - Am J Clin Nutr. 2010 Dec 8 - "Of the 75 relevant studies located, we considered 38 studies to be appropriate for review. Results revealed support for intakes of omega-3 (n-3) fish oils (Cohen's d = 0.21-0.81) and soy isoflavones (Cohen's d = 0.35-0.39) in the treatment of arterial stiffness. There was limited but consistent evidence to suggest that salt restriction (Cohen's d = 0.28-0.37) as well as consumption of fermented-milk products (Cohen's d = 0.15-0.33) that contain bioactive peptides improved arterial stiffness. The evidentiary support for intakes of vitamins, micronutrients, and herbal medicines was insufficient. Limited but consistent evidence suggested that caffeine intake acutely increased arterial stiffness (Cohen's d = 0.34-0.51) ... Current evidence from several small studies suggests that omega-3 and soy isoflavone supplementation provides an effective means of reducing arterial stiffness" - See soy isoflavones at Amazon.com and Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.

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