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Anti-aging Research > N-acetyl-L-cysteine (NAC)
News & Research:
Fresh faced: Looking younger for longer - Science Daily, 1/10/14 -
"While UVB radiation easily causes sunburn, UVA
radiation penetrates deeper, damaging our DNA by generating free radicals
which degrades the collagen that gives skin its elastic quality ... the most
potent anti-oxidants were those that targeted the batteries of the skin
cells, known as the mitochondria. They compared these mitochondrial-targeted
anti-oxidants to other non-specific antioxidants such as resveratrol, found
in red wine, and curcumin found in curries, that target the entire cell.
They found that the most potent mitochondrial targeted anti-oxidant was
Tiron which provided 100%, protection of the skin cell against UVA sun
damage and the release of damaging enzymes causing stress-induced damage ...
Tiron is not a naturally occurring compound and has not yet been tested for
toxicity in humans although there have been a few studies on rats ...
Antioxidants in our diets from green tea, resveratrol which is found in red
wine, turmeric which is used in curries and lycopene found in tomatoes, as
well as some components in cosmetic creams, are known to neutralise this
damage within the cells. They can slow down the damage and the rate of aging
and potentially lower the rate of other sun-induced skin lesions ...
Resveratrol, the antioxidant found in red wine, was found to protect against
22% of both the ultraviolet A radiation and stress-induced damage. NAC, a
frequently used laboratory-based anti-oxidant, offered 20% protection
against oxidative stress and 8% against UVA and curcumin offered 16%
protection against oxidative stress and 8% against UVA" - See
resveratrol products at Amazon.com
n-acetyl cysteine at Amazon.com.
Amino acid offers potential therapeutic alternative in psychiatric disorders
- Science Daily, 10/8/13 - "drug discovery is at a
near standstill for treating psychiatric disorders such as schizophrenia,
bipolar disorder, depression and common forms of autism ... According to
Professor Berk, there is now an incontrovertible evidence base that these
disorders share inflammation and oxidative stress as part of their disease
physiology ... The amino acid, NAC, seems to have multiple effects on all
these pathways: it boosts glutathione, which is the body’s major antioxidant
defence; has anti-inflammatory properties; enhances levels of nerve cell
growth proteins and the growth of new neurons; and reduces cell death
pathways. It also appears to reduce dysfunction of mitochondria ... NAC
reduces the core symptoms of schizophrenia including negative symptoms such
as improved apathy, social interaction and motivation. It also appears to
reduce depression in people with bipolar disorder and at this meeting ...
there is intriguing evidence that it reduces cravings in a number of
addictions including cocaine, cannabis and cigarette smoking"
Neuron loss in schizophrenia and depression could be prevented, study
suggests - Science Daily, 3/13/13 - "It now
appears that parvalbumin neurons are particularly vulnerable to oxidative
stress, a factor that may emerge commonly in development, particularly in
the context of psychiatric disorders like schizophrenia or bipolar disorder,
where compromised mitochondrial function plays a role. Parvalbumin neurons
may be protected from this effect by N-acetylcysteine, also known as
Mucomyst, a medication commonly prescribed to protect the liver against the
toxic effects of acetaminophen (Tylenol) overdose ... This study raises the
possibility that GABA neuronal deficits in psychiatric disorder may be
preventable using a drug, N-acetylcysteine, which is quite safe to
administer to humans"
Antioxidant improves donated liver survival rate to more than 90% -
Science Daily, 2/25/13 - "Results indicate that
graft survival rates at 3 and 12 months were 93% and 90%, respectively, for
patients receiving NAC infused livers; rates were 82% and 70% in the control
group. Post-transplant complication rates were 23% for the NAC group and 51%
in the control group. Analysis of the 61 patients receiving suboptimal
livers the incidence of organ dysfunction was lower in the NAC group
compared to controls at 15% and 32%, respectively"
Natural antioxidant can protect against cardiovascular disease - Science
Daily, 6/16/12 - "The enzyme -- glutathione
peroxidase, or GPx3 -- is a natural antioxidant that helps protect organisms
from oxidant injury and helps the body naturally repair itself. Researchers
have found that patients with high levels of good cholesterol, the GPx3
enzyme does not make a significant difference. However, those patients with
low levels of good cholesterol, the GPx3 enzyme could potentially be a big
benefit ... The new research, published June 16 by PLoS One, supports the
view that natural antioxidants may offer the human body profound benefits
... people with high levels of the GPx3 enzyme and low levels of good
cholesterol were six times less likely to develop cardiovascular disease
than people with low levels of both"
supplements pills benefit and side effects - raysahelian.com -
"This antioxidant, made from the combination of
three amino acids cysteine, glutamate, and glycine, forms part of the
powerful natural antioxidant glutathione peroxidase which is found in
our cells ... Supplements that help make glutathione ... Acetylcysteine
... ALA ... Pycnogenol ... The frequent use of acetaminophen (Tylenol)
depletes glutathione peroxidase levels" - See
n-acetyl cysteine at Amazon.com.
N-Acetylcysteine Mucolysis in the Management of COPD : Abstract and
Introduction - Medscape, 6/14/12 - "NAC may
exert its mucolytic and mucoregulatory action via several mechanisms (Figure
3). First, it works through depolymerization of the mucin glycoprotein
oligomers by hydrolyzing the disulfide bonds that link the mucin monomers.
This is possible because of the presence of free thiols (sulfhydryl groups).
Therefore, NAC decreases the sputum viscosity in vitro [Sheffner, 1963;
Davis et al. 1975] and acts as a mucolytic. Second, it plays a
mucoregulatory role as it can decrease sputum hypersecretion in experimental
rat models [Rogers et al. 1989]. Moreover, it has been demonstrated to
inhibit the mucus secretory cell hyperplasia and enhanced expression of the
MUC5AC gene in bleomycin-induced lung fibrosis in rats [Mata et al. 2003]"
Antioxidant shows promise as treatment for certain features of autism -
Science Daily, 5/29/12 - "The antioxidant, called
N-Acetylcysteine, or NAC, lowered irritability in children with autism as
well as reducing the children's repetitive behaviors"
N-Acetyl Cysteine Effective for Bipolar Depression - Medscape, 6/10/11 -
"oxidative stress and inflammation play a role in
the pathophysiology of bipolar disorder ... NAC is a cysteine analogue shown
to effectively raise plasma levels of the primary antioxidant, glutathione.
NAC also modulates cytokines, glutamates neurotransmission, and enhances
neurogenesis ... significant differences (P < .001) were found between
baseline and week 8 for all study measures. Minimal side effects occurred"
- Note: That seems like a high dose but I would think most would take a
lower lower dose over a longer period of time which may be as effective.
Antioxidant Study Suggests Possibility of "Sunburn Pill" - Medscape,
12/11/09 - "The researchers theorize that people at
increased risk for melanoma could take NAC as a "sunburn pill" before
exposure to large amounts of sunlight. Such an approach, they add, could
theoretically reduce a person's lifetime risk of melanoma and also minimize
the problems associated with taking a daily medication"
Amino Acid May Help Reduce Cocaine Cravings - Science Daily, 10/23/09 -
"N-acetylcysteine (NAC), a commonly available and
generally nontoxic amino acid derivative, reverses changes in the brain's
circuitry associated with cocaine addiction. The reversal appears to lessen
the cravings associated with cocaine, thus providing protection against
relapse" - See
n-acetyl cysteine at Amazon.com.
Medication Effective For Acute Liver Failure In Early Stages Of Disease,
Study Suggests - Science Daily, 10/8/09 -
"Researchers found that 52 percent of acute liver failure patients in mild
to moderate comas survived when treated with NAC, compared to just 30
percent of those treated with only a placebo. In patients experiencing more
severe coma, treatment with NAC did not result in a significant difference
in survival rates" - See
n-acetyl cysteine at Amazon.com.
High-Dose N-Acetylcysteine Reduces Contrast Nephropathy - Medscape,
9/14/09 - "the odds of contrast-induced nephropathy
were 54% lower in patients randomized to high-dose N-acetylcysteine,
compared to those randomized to a control group"
Health Food Supplement May Curb Compulsive Hair Pulling - Science Daily,
7/6/09 - "Patients were given 1,200 mg of
N-Acetylcysteine every day for six weeks. For the following six weeks, the
dosage was increased to 2,400 mg per day. After nine weeks, those on
supplement had significantly reduced hair-pulling. By the end of the 12 week
study, 56 percent reported feeling much or very much improved, while only 16
percent on the placebo reported less pulling"
Therapeutic Properties Of N-acetyl-L-cysteine Discovered - Science
Daily, 1/19/09 - "N-acetyl-L-cysteine (NAC) combined
with mesalamine produces a significant improvement in patients suffering
from ulcerative colitis ... N-acetyl-L-cysteine, is a drug normally used for
the treatment of chronic obstructive pulmonary disease (COPD) and to
minimize the effects of cold and flu. Its hepatic protective properties also
make this drug a useful tool in paracetamol intoxications ...
N-acetyl-L-cysteine reduced the negative effects caused by azathioprine, a
immunosuppressant of clinical use, on the liver"
Add-On Therapy Improves Depressive Symptoms In Bipolar Disorder -
Science Daily, 9/2/08 - "sought to evaluate whether
N-acetyl cysteine (NAC), an over-the-counter supplement that increases brain
glutathione, might help alleviate depressive symptoms ... Glutathione is the
brain’s primary antioxidant defense, and there is evidence of increased
oxidative stress in bipolar disorder. Therefore, we studied the potential
benefit of NAC treatment in bipolar disorder and found that it impressively
remedied residual depressive symptoms" - See
n-acetyl cysteine at Amazon.com.
Before A CT Scan Or Angiogram, Many People Should Take Inexpensive Drug To
Protect Kidneys - Science Daily, 2/18/08 - "The
inexpensive drug, called N-acetylcysteine, can prevent serious kidney damage
that can be caused by the iodine-containing "dyes" that doctors use to
enhance the quality of such scans ... N-acetylcysteine is already widely
used to clear mucus in cystic fibrosis patients, and to treat overdoses of
Treatment With NAC Is Associated With Better Outcomes For Children With
Liver Failure, Study Suggests - Science Daily, 1/3/08 -
"The children who received NAC spent fewer days in
intensive care, and in the hospital overall. 43 percent survived with their
native liver, compared to 22 percent of children who did not receive NAC.
And death rates while awaiting transplant, after transplant, and after ten
years were notably lower in children who had received NAC"
N-acetyl Cysteine May Aid in Treatment of Schizophrenia - Doctor's
Guide, 10/16/07 - "The study showed that NAC
improves certain symptoms of schizophrenia, and therefore implicated
glutathione deficiency in the pathogenesis"
Short-Course N-Acetylcysteine Effective for Acetaminophen Overdose -
Medscape, 10/4/07 - "A shortened course of as few as
six oral doses of N-acetylcysteine appears to be an effective treatment for
certain patients with acute acetaminophen poisoning"
Health Food Supplement May Curb Addiction Of Pathological Gamblers -
Science Daily, 9/11/07
Vitamin C Stops Cancer - Science Daily, 9/10/07 -
"Both of these cancers produce high levels of free radicals that can be
suppressed by feeding the mice supplements of antioxidants, either vitamin C
or N-acetylcysteine (NAC) ... Some rapidly growing tumors consume enough
energy to easily suck out the available oxygen in their vicinity, making
HIF-1 absolutely critical for their continued survival. But HIF-1 can only
operate if it has a supply of free radicals. Antioxidants remove these free
radicals and stop HIF-1, and the tumor, in its tracks" - See
vitamin C products at Amazon.com.
One Type Of Antioxidant May Not Be As Safe As Once Thought - Science
Daily, 9/4/07 - "The research team administered both
NAC and nitrosothiols to mice for three weeks. The NAC was converted by red
blood cells into the nitrosothiol, S-nitroso-N-acetylcysteine (SNOAC). The
normal mice that received NAC and SNOAC developed PAH. Mice missing an
enzyme known as endothelial nitric oxide synthase did not convert NAC to
SNOAC, and were protected from the adverse effects of NAC, but not SNOAC.
This suggests that NAC must be converted to SNOAC to cause PAH ... Could
regular use of NAC produce the same effects in humans? The next step is to
determine a threshold past which antioxidant use becomes detrimental to
heart or lung function"
Antioxidant, B vitamin Combo to slow dementia? - Nutra USA, 12/6/04 -
"the glutathione precursor N-acetylcysteine (NAC) is not only a potent
antioxidant but also a source of cysteine. Cysteine is required to generate
hydrogen sulphide - an important neuromodulator and vasorelaxant. Levels of
hydrogen sulphide levels are severely decreased in the brains of Alzheimer’s
No Difference between N-Acetylcysteine and Fenoldopam for Thwarting
Contrast-Induced Nephropathy - Doctor's Guide, 11/8/04 -
"A randomized study failed to show a significant difference in the ability
of oral N-acetylcysteine (NAC) and intravenous fenoldopam (FEN) to prevent
the deterioration in renal function"
NAC supplement for brain damage in boys - Nutra USA, 5/4/04 -
"Because it enhances the production of the enzyme
glutathione, NAC is thought to both stave off disease and play an important
role in boosting the immune system"
Thiol-Containing Antioxidant Shows Promise in Preventing Contrast
Nephropathy - Doctor's Guide, 8/25/03 -
"Treatment with acetylcysteine, a thiol-containing
antioxidant, shows promise in preventing contrast nephropathy in patients
with chronic renal insufficiency"
High Cysteine Levels Linked to Lower Rates of Breast Cancer
- Doctor's Guide, 7/15/03 - "Women in the highest
quintile for measured cysteine levels in this study had a 56% lower risk of
invasive or in situ breast cancer
than women in the lowest quintile ... The findings were more pronounced when
only invasive cancer was considered ... Cysteine or its precursors might
have the potential to be chemoprotective against breast cancer"
- N-Acetyl Cysteine
Prevents Kidney Damage from Coronary Procedure
- New Hope Natural Media, 5/1/03 -
"Up to 15% of people undergoing coronary angiography
kidney damage from the contrast dye ...
randomly assigned to receive either 600 mg of oral NAC twice a day on the
day before and the day of the procedure or a similar looking placebo ...
Only 4% of those taking NAC, compared with 12% of those taking the placebo,
experienced a 25% increase in blood creatinine within 48 hours of receiving
the contrast dye"
Cardiovascular End Points Reduced With Antioxidant Acetylcysteine In
Haemodialysis Patients - Doctor's Guide, 2/28/03 -
"They were assigned to receive either
600 mg twice daily or a placebo ... Primary end point was a composite
variable composed of cardiac events that included fatal and non-fatal
myocardial infarction, death from cardiovascular disease, necessity for
either coronary angioplasty or by-pass surgery, ischaemic stroke, peripheral
vascular disease requiring amputation or need for angioplasty ... A primary
end point was established in 18 of the 64 [28%] haemodialysed patients who
received acetylcysteine, and 33 of 70 [47%] patients undergoing
haemodialysis assigned to the control group"
- N-Acetyl Cysteine
Improves Insulin Resistance in Women with Polycystic Ovary Syndrome -
New Hope Natural Media, 12/12/02 -
"PCOS ... affects up to 10% of all women of
reproductive age ... characterized by enlargement of the ovaries, irregular
menstrual cycle, failure to ovulate, obesity, high levels of insulin in the
blood and insulin resistance, excessive hair growth (due to increased
testosterone) and infertility. More than 50% of all women with PCOS have
high insulin levels, which may be a risk factor for diabetes, high blood
pressure, blood clots and heart disease ... Women with high initial insulin
levels who took NAC had a significant reduction in insulin levels following
the glucose tolerance test and also showed improved insulin sensitivity"
Acetylcysteine Can Reduce Cardiovascular Events in Patients with Endstage
Renal Disease - Doctor's Guide, 10/1/02 -
"therapy with acetylcysteine appears to
significantly reduce cardiovascular events among
haemodialysis patients" - See
n-acetyl cysteine at Amazon.com.
- Getting More Glutathione?
- Dr. Weil, 8/29/02 -
"To my knowledge, the only supplement that
glutathione levels in the body is
N-acetyl-L-cysteine (NAC). My colleague Kathleen Johnson, a dietician here
at the Program in Integrative Medicine, tells me that other glutathione
supplements are ineffective because they’re digested before they can get
into the bloodstream"
Putting Antioxidants To Use In Functional Formulas - Functional Foods &
Nutraceuticals, 5/02 - "N-acetylcysteine (NAC), like
alpha-lipoic acid, is a potential antioxidant and precursor to glutathione.
However, NAC is also a powerful immune stimulant. For example, an Italian
study of 262 elderly subjects found that 600mg NAC, taken twice daily,
reduced flu symptoms by two-thirds.18 Large dosages of NAC—up to several
grams daily—can extend the life expectancy of patients with AIDS,19 and some
research suggests that it may also reduce the risk of cancer"
Acetylcysteine Prevents Renal Problems After Angiography
- Doctor's Guide, 3/18/02 - "Changes in creatinine
mean values after 48 hours were -0.4 (+/-0.3) and +0.1 (+/-0.3) mg/dL for
treatment and control groups, respectively (p<0.001). The benefit was larger
in patients with baseline creatinine levels higher than 2 mg/dL, at -0.4
(+/-0.4) compared to +0.5 (+/-0.3) mg/dL (p<0.001)"
Antioxidant Boosts Cognitive Function In Alzheimer's Patients
- Intelihealth, 11/15/01 - "the antioxidant
N-acetylcysteine (NAC) may improve certain cognitive skills in people with
Alzheimer's disease ... Although participants in the NAC group did not
outperform placebo patients in day-to-day activities, they did fare
significantly better than the placebo group on certain cognitive tests"
N-acetylcysteine Improves Blood Vessels - Nutrition Science News, 5/01 -
"Researchers suspect this is because NAC enhances
the bioavailability of the relaxing substance nitric oxide, but because
nitric oxide has a short half-life and cannot be measured by current
methodology, they were unable to determine this directly. In addition, NAC
may act as an antioxidant that protects nitric oxide destruction"
Glutathione: The Eye Healer Within - Nutrition Science News, 4/01 -
"Supplementing with glutathione to boost glutathione levels is not well
understood. Glutathione is a large molecule that is not easily absorbed, but
it is a tripeptide with cysteine—a sulfur-bearing amino acid—in the middle.
As cysteine is broken down in the digestive tract, its sulfur is absorbed
and utilized to make more glutathione"
'Medical Food' May Slow
Brain Atrophy in Patients With Alzheimer's and Related Disorders - Medscape,
10/31/16 - "In a study of 67 participants, those
with both HHcy and ADRD who took the L-methylfolate, methylcobalamin, and
N-acetyl-cysteine product for 2 years had an adjusted hippocampal atrophy rate
more than 4 times slower than that in the participants with ADRD and no HHcy who
did not take the prescription medical food. The rate of cortical atrophy was
more than 11 times slower in the treatment group ... the reductions in rate of
brain tissue loss "were quite dramatic" and he especially didn't expect the
cortical finding ... The take-away message…is that elevated homocysteine is
common and should be regularly checked for in all persons over 50 years old, and
it should be treated when found ... HHcy has a worldwide prevalence of 5.1% to
29% in individuals who are older than 65 years. "Furthermore, the odds of brain
atrophy are up to 10 times higher in HHcy patients than in those with normal
homocysteine levels,"" - See L-methylfolate,
N-acetyl-cysteine at Amazon.com.
Reduces Infarct Size - Medscape, 8/28/16 - "Cardiac magnetic resonance (CMR)
imaging performed within 1 week and again 3 months post-MI showed that patients
who received NAC had reductions in infarct size of 33% and 50%, respectively,
compared with placebo ... Over 2 years of follow-up, the combination of cardiac
readmissions and deaths was less frequent in NAC-treated (three vs 16 patients"
n-acetyl cysteine at Amazon.com.
N-acetylcysteine reduces plasma homocysteine concentrations regardless of lipid
or smoking status - Am J Clin Nutr. 2015 Oct 7 - "hyperlipidemic
group (HYL ... Four weeks of oral NAC treatment significantly decreased plasma
tHcy concentrations, irrespective of lipid or smoking status, and lowered
systolic blood pressure in both normolipidemic and hyperlipidemic men, with
significant diastolic blood pressure reductions in the HYL group only. Increased
oral intake of cysteine may therefore be considered for primary or secondary
prevention of vascular events with regard to the 2 independent risk factors of
hyperhomocysteinemia and arterial hypertension"
treatment ameliorates experimental diabetes-induced depressive-like behavior and
reduces oxidative stress in brain and pancreas - Diabetes Metab Res Rev.
2015 Oct 3 - "This study aimed to evaluate the effects
of antioxidants n-acetylcysteine (NAC) and deferoxamine (DFX) on behavior and
oxidative stress parameters in diabetic rats. To this aim, after induction of
diabetes by a single dose of alloxan, Wistar rats were treated with NAC or DFX
for 14 days and then depressive-like behavior was evaluated ... Diabetic rats
displayed depressive-like behavior and treatment with NAC reversed this
alteration. Carbonyl protein levels were increased in the PFC, hippocampus, and
pancreas of diabetic rats, and both NAC and DFX reversed these alterations.
Lipid damage was increased in the PFC, hippocampus, amygdala, and pancreas,
however treatment with NAC or DFX reversed lipid damage only in the hippocampus
oxidative status in major abdominal surgery patients after N-acetyl cystein
supplementation - Nutr J. 2015 Jan 6;14(1):4 -
"Increased levels of reactive oxygen species during and after surgery may affect
inflammatory response, post-operative adhesion molecule formation, and
hemodynamic stability. The glutathione redox cycle is an important regulator in
oxidative stress and its reduced forms scavenge free radicals. N-acetyl
cysteine, a precursor of reduced glutathione, is considered as a potentially
therapeutic wide spectrum agent in clinical practice ... Thirty-three patients
diagnosed with pancreas, stomach, rectum, colon malignancies, and undergoing
major abdominal surgery ... The study demonstrated the clinical importance of
N-acetyl cysteine supplementation on antioxidant parameters in abdominal surgery
patients. In these patients N-acetyl cysteine and vitamin administration can be
considered as an effective method for improvement of oxidative status"
redox imbalance in brain disorders - Curr Opin Clin Nutr Metab Care. 2014
Nov 15 - "we summarize current evidence on how GSH
depletion and GSH-related enzyme deficit are involved in the pathology of brain
disorders such as autism, schizophrenia, bipolar disorder, Alzheimer's disease,
and Parkinson's disease ... The potential therapeutic agents for brain disorders
include N-acetylcysteine, liposomes encapsulated with GSH, and whey protein
supplement, which can increase the GSH levels in the brain and alleviate
oxidative stress-associated damage and may improve the behavior of individuals
with brain diseases ... GSH plays an important role during the onset and
progression of neuropsychiatric and neurodegenerative diseases. GSH redox
imbalance may be a primary cause of these brain disorders and may be used as a
biomarker for diagnosis of these diseases. N-acetylcysteine and other agents
that can increase the concentration of GSH in the brain are promising approaches
for the treatment of these brain disorders"
N-acetylcysteine prevents endoplasmic reticulum stress elicited in macrophages
by serum albumin drawn from chronic kidney disease rats and selectively affects
lipid transporters, ABCA-1 and ABCG-1 - Atherosclerosis. 2014 Sep
30;237(1):343-352 - "NAC may contribute to attenuate the
deleterious effects of CKD-albumin on lipid accumulation in macrophages helping
to prevent atherogenesis in CKD"
N-Acetylcysteine administration prevents nonthyroidal illness syndrome in
patients with acute myocardial infarction: a randomized clinical trial - J
Clin Endocrinol Metab. 2014 Aug 22 - "The acute phase of
the non-thyroidal syndrome (NTIS) is characterized by low triiodothyronine (T3)
and high reverse T3 (rT3) levels, affecting up to 75% of critically ill
patients. Oxidative stress has been implicated as a causative factor of the
disturbed peripheral thyroid hormone metabolism ... NAC administration prevents
the derangement in thyroid hormone concentrations commonly occurring in the
acute phase of acute myocardial infarction, indicating that oxidative stress is
involved in the NTIS pathophysiology"
N-Acetylcysteine Supplementation Decreases Osteoclast Differentiation and
Increases Bone Mass in Mice Fed a High-Fat Diet - J Nutr. 2013 Dec 31 -
"Obesity induced by high-fat (HF) diets increases bone
resorption, decreases trabecular bone mass, and reduces bone strength in various
animal models ... Forty-eight 6-wk-old male C57BL/6 mice were randomly assigned
to 4 treatment groups (n = 12 per group) and fed either a normal-fat [NF (10%
energy as fat)] or an HF (45% energy as fat) diet ad libitum with or without NAC
supplementation at 1 g/kg diet for 17 wk ... These results show that NAC
supplementation increases the bone mass of obese mice induced by an HF diet
through elevating glutathione status and decreasing bone resorption"
Double-Blind Randomized Controlled Trial of N-Acetylcysteine in
Cannabis-Dependent Adolescents - Am J Psychiatry. 2012 Jun 15 -
"Participants receiving NAC had more than twice the
odds, compared with those receiving placebo, of having negative urine
cannabinoid test results during treatment (odds ratio=2.4, 95% CI=1.1-5.2) ...
Findings support NAC as a pharmacotherapy to complement psychosocial treatment
for cannabis dependence in adolescents"
synthesis of glutathione underlies oxidative stress in aging and can be
corrected by dietary cysteine and glycine supplementation - Am J Clin Nutr.
2011 Jul 27 - "Compared with younger control subjects,
elderly subjects had markedly lower RBC concentrations of glycine (486.7 +/-
28.3 compared with 218.0 +/- 23.7 μmol/L; P < 0.01), cysteine (26.2 +/- 1.4
compared with 19.8 +/- 1.3 μmol/L; P < 0.05), and glutathione (2.08 +/- 0.12
compared with 1.12 +/- 0.18 mmol/L RBCs; P < 0.05); lower glutathione fractional
(83.14 +/- 6.43% compared with 45.80 +/- 5.69%/d; P < 0.01) and absolute (1.73
+/- 0.16 compared with 0.55 +/- 0.12 mmol/L RBCs per day; P < 0.01) synthesis
rates; and higher plasma oxidative stress (304 +/- 16 compared with 346 +/- 20
Carratelli units; P < 0.05) and plasma F(2)-isoprostanes (97.7 +/- 8.3 compared
with 136.3 +/- 11.3 pg/mL; P < 0.05). Precursor supplementation in elderly
subjects led to a 94.6% higher glutathione concentration, a 78.8% higher
fractional synthesis rate, a 230.9% higher absolute synthesis rate, and
significantly lower plasma oxidative stress and F(2)-isoprostanes. No
differences in these measures were observed between younger subjects and
supplemented elderly subjects ... Glutathione deficiency in elderly humans
occurs because of a marked reduction in synthesis. Dietary supplementation with
the glutathione precursors cysteine and glycine fully restores glutathione
synthesis and concentrations and lowers levels of oxidative stress and oxidant
damages. These findings suggest a practical and effective approach to decreasing
oxidative stress in aging" - See
l-glycine at Amazon.com
n-acetyl cysteine at Amazon.com.
dietary antioxidant cocktail supplementation effectively reduces renal
inflammation in diabetic mice - Br J Nutr. 2011 Jun 3:1-8 -
"Diabetic nephropathy is a serious complication for
diabetic patients, yet the precise mechanism that underlies the development of
diabetic complications remains unknown. We hypothesised that dietary antioxidant
supplementation with single N-acetylcysteine (NAC) or vitamin C combined with
either vitamin E or vitamin E and NAC improves diabetic renal inflammation
through the modulation of blood glucose levels, oxidative stress and
inflammatory response. Experimental animals were treated with alloxan
monohydrate to induce diabetes. Mice were divided into five groups and
supplemented with single or a combination of antioxidants. Body weights and
blood glucose levels were measured once a week. After 8 weeks of dietary
antioxidant supplementation, mice were killed and blood urea N (BUN) and plasma
creatinine levels were measured to evaluate renal function. NF-κB protein was
indirectly demonstrated by the phosphorylated IκBα (pIκBα) level, and the
expressions of oxidative stress- and inflammatory response-related proteins were
also determined. We demonstrated that dietary antioxidant supplementation
decreased lipid peroxidation levels demonstrated by thiobarbituric acid-reacting
substances, BUN and plasma creatinine levels in diabetic kidneys. Moreover,
dietary antioxidant cocktail supplementation improved blood glucose levels and
selectively regulated the expressions of Cu-Zn superoxide dismutase, haeme
oxygenase-1, pIκBα, inducible NO synthase, cyclo-oxygenase-2 and C-reactive
protein in diabetic kidneys effectively. These findings demonstrated that
diabetic renal failure was associated with inflammatory responses induced by
hyperglycaemia. In addition, results in the study suggest that antioxidant
cocktail supplementation may have beneficial effects on diabetic nephropathy
through selective reduction of blood glucose levels and inflammatory response"
N-acetylcysteine in psychiatry: current therapeutic evidence and potential
mechanisms of action - J Psychiatry Neurosci. 2010 Nov 1;35(6):100057 -
"This review outlines the current literature regarding
the use of NAC in disorders including addiction, compulsive and grooming
disorders, schizophrenia and bipolar disorder. N-acetylcysteine has shown
promising results in populations with these disorders, including those in whom
treatment efficacy has previously been limited. The therapeutic potential of
this acetylated amino acid is beginning to emerge in the field of psychiatric
N-Acetylcysteine interacts with copper to generate hydrogen peroxide and
selectively induce cancer cell death - Cancer Lett. 2010 Jul 26 -
"NAC/Cu(II) significantly alters growth and induces apoptosis in human cancer
lines, yet NAC/Zn(II) and NAC/Fe(III) do not. We further confirmed that this
cytotoxicity of NAC/Cu(II) is attributed to reactive oxygen species (ROS). These
findings indicate that the combination of Cu(II) and thiols generates cytotoxic
ROS that induce apoptosis in cancer cells. They also indicate a fourth class of
anti-neoplastic metal-binding compounds, the "ROS generators""
of N-acetylcysteine on Semen Parameters and Oxidative/Antioxidant Status
- Urology. 2009 May 8 - "To examine whether a
beneficial effect of N-acetylcysteine (NAC) on semen parameters and
oxidative/antioxidant status in idiopathic male infertility exists ... NAC
had significant improving effects on the volume, motility, and viscosity of
semen" - See
n-acetyl cysteine at Amazon.com.
N-acetylcysteine versus AScorbic acid for Preventing contrast-Induced
nephropathy in patients with renal insufficiency undergoing coronary
angiography NASPI study-a prospective randomized controlled trial - Am
Heart J. 2009 Mar;157(3):576-583 - "High-dose NAC
seems more beneficial than ascorbic acid in preventing contrast-induced
deterioration in patients, especially
diabetic patients, with renal insufficiency undergoing coronary angiography"
of alpha-tocopherol, N-acetylcysteine and omeprazole on esophageal
adenocarcinoma formation in a rat surgical model - Int J Cancer. 2008
Oct 20 - "oxidative stress subsequent to
gastroesophageal reflux is an important driving force of esophageal
adenocarcinoma (EAC) formation in the esophagogastroduodenal anastomosis
(EGDA) rat model. This study investigated the possible tumor inhibitory
effects of 2 antioxidants, alpha-tocopherol (389 and 778 ppm),
N-acetylcysteine (NAC, 500 and 1,000 ppm), and their combination (389 and
500 ppm, respectively), as well as an antacid therapeutic agent, omeprazole
(1,400 ppm) ... alpha-Tocopherol dose-dependently decreased the incidence of
EAC (p = 0.03), with 778 ppm alpha-tocopherol reducing the incidence of EAC
to 59% (16/27) in comparison with 84% (26/31) in the control group (p =
0.04). Supplementation of alpha-tocopherol also increased the serum
concentration of alpha-tocopherol. NAC at 500 and 1,000 ppm did not
significantly decrease EAC incidence; however, the combination of
alpha-tocopherol 389 ppm and NAC 500 ppm significantly reduced the incidence
of EAC to 55% (15/27) (p = 0.02). alpha-Tocopherol alone or in combination
with NAC significantly reduced the number of infiltrating cells positively
stained for 4-hydroxynonenal. Omeprazole showed only a slight nonsignificant
inhibitory effect at the dose given"
of a Vitamin/Nutriceutical Formulation for Early-stage Alzheimer's Disease:
A 1-Year, Open-Label Pilot Study With an 16-Month Caregiver Extension -
Am J Alzheimers Dis Other Demen. 2008 Dec 1 - "We
examined the efficacy of a vitamin/nutriceutical formulation (folate,
vitamin B6, alpha-tocopherol, S-adenosyl methionine, N-acetyl cysteine, and
acetyl-L-carnitine) in a 12-month, open-label trial with 14
community-dwelling individuals with early-stage Alzheimer's disease.
Participants improved in the Dementia Rating Scale and Clock-drawing tests
(Clox 1 and 2). Family caregivers reported improvement in multiple domains
of the Neuropsychiatric Inventory (NPI) and maintenance of performance in
the Alzheimer's Disease Cooperative Study-Activities of Daily Living (ADL).
Sustained performance was reported by caregivers for those participants who
continued in an 16-month extension. Performance on the NPI was equivalent to
published findings at 3 to 6 months for donepezil and exceeded that of
galantamine and their historical placebos. Participants demonstrated
superior performance for more than 12 months in NPI and ADL versus those
receiving naproxen and rofecoxib or their placebo group. This formulation
holds promise for treatment of early-stage Alzheimer's disease prior to
and/or as a supplement for pharmacological approaches"
N-Acetylcysteine prevents ifosfamide-induced nephrotoxicity in rats - Br
J Pharmacol. 2008 Feb 18 - "NAC markedly reduces the
severity of renal dysfunction induced by ifosfamide with a significant
decrease in elevations of serum creatinine (57.8+/-2.3 vs 45.25+/-2.1 mumol
l(-1)) as well as a reduced elevation of beta(2)-microglobulin excretion
(25.44+/-3.3 vs 8.83+/-1.3 nmol l(-1)) and magnesium excretion (19.5+/-1.5
vs 11.16+/-1.5 mmol l(-1)). Moreover, NAC significantly improved the
ifosfamide-induced glutathione depletion and the decrease of glutathione
S-transferase activity, lowered the elevation of lipid peroxides and
prevented typical morphological damages in renal tubules and glomeruli"
n-acetyl cysteine at Amazon.com.
Long Term N-Acetylcysteine and L-Arginine Administration Reduces Endothelial
Activation and Systolic Blood Pressure in Hypertensive Patients with Type 2
Diabetes Mellitus - Diabetes Care. 2008 Feb 11 -
"The NAC+ARG administration seems to be a potential well-tolerated
antiatherogenic therapy since it improves the endothelial function in
hypertensive patients with type 2 diabetes by improving NO bioavailability
via reduction of the oxidative stress and increase of NO production. Our
study's results give prominence to its potential use in the primary and
secondary cardiovascular prevention in these patients"
N-acetylcysteine for the prevention of postoperative atrial fibrillation: a
prospective, randomized, placebo-controlled pilot study - Eur Heart J.
2008 Feb 8 - "The result of this study indicates
that NAC treatment decreases the incidence of postoperative AF" - See
n-acetyl cysteine at Amazon.com.
Effects of folic acid
and N-acetylcysteine on plasma homocysteine levels and endothelial function
in patients with coronary artery disease - Acta Cardiol. 2007
Dec;62(6):579-85 - "either folic acid 5 mg or NAC
600 mg or placebo daily for eight weeks ... endothelium-dependent dilation
(EDD) ... Folic acid and NAC therapies decreased plasma homocysteine (from
21.7 +/- 8.7 micromol/l to 12.5 +/- 2.5 micromol/l, P < 0.001; from 20.9 +/-
7.6 micromol/l to 15.6 +/- 4.3 micromol/l, P = 0.03, respectively), and
increased EDD (6.7 +/- 6.1% P = 0.002, 4.4 +/- 2.6% P < 0.001, respectively)
compared with placebo. There was no significant difference in improving EDD
between the folic acid and the NAC group"
Telmisartan, an Angiotensin II Type 1 Receptor Blocker, Inhibits Advanced
Glycation End-product (AGE)-induced Monocyte Chemoattractant Protein-1
Expression in Mesangial Cells Through Downregulation of Receptor for AGEs
via Peroxisome Proliferator-activated Receptor-gamma Activation - J Int
Med Res. 2007 Jul-Aug;35(4):482-9 - "Candesartan, an
Ang II type 1 receptor blocker, did not suppress AGEs-induced superoxide
generation. Telmisartan and the antioxidant, N-acetylcysteine, completely
inhibited AGEs-induced MCP-1 overproduction by mesangial cells"
Acetylcysteine for Prevention of Acute Deterioration of Renal Function
Following Elective Coronary Angiography and Intervention: A Randomized
Controlled Trial - JAMA, 2/5/03 -
protects patients with moderate chronic
renal insufficiency from contrast-induced
deterioration in renal function after coronary angiographic procedures, with
minimal adverse effects and at a low cost" - See
n-acetyl cysteine at Amazon.com.
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