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Recent Longevity News for the week ending 2/2/22 YouTube disclaimer: There's a lot of BS on YouTube but that's where the money is. I lose money every month with my website while I see the YouTubers making six figures putting out information that's inaccurate and/or outright bogus. Like the chiropractor or the elderly male Ph.D. nurse with dementia from England who puts out misinformation like promoting ivermectin and gets a million views with a couple days. An example is his recent video implying that vaccines aren't that effective and we should go with natural immunity. I don't agree with everything Dr. Stanfield says such as taking finasteride and estrogen (I think he saw what happened to Opie Taylor on Andy Griffith) but he's one of the better ones. Look at the number of views (Stanfield doesn't get that many). The more views, it seems like the more inaccurate the information is. Just like politics. They feed on peoples' ignorance for money and/or power while throwing America under the bus. An honest politician would never get to first base. There’s an up and coming new doctor pushing things like ivermectin that’s also doing well. Shameful. See Freedom of misinformation: Dr. John Campbell's misuse and manipulation of Covid-19 deaths - "As a (retired) physician with both clinical and medical microbiology training I thought you did a great job not only explaining in one of your other videos the papers that Campbell misinterpreted". According to Wikipedia, Dr. Campbell is 63 or 64 years old. He looks like he's 85. Whatever he's doing isn't working. Recently he's been interviewing people who got sick from the Covid vaccine. Why doesn't he interview the people who lost loved ones because of people who did not get the vaccine and that number is exponentially higher? He's up there with the Joe Rogan's of the world that made their name by feeding on peoples' ignorance at the cost of peoples' lives. The guy is pure evil plus he's senile yet he's a social media darling. What's become of the world? Why do people go gaga over this clown? I actually know people who use the argument that they know someone that got the vaccine and still contracted Covid so why should they get the vaccine. I don’t doubt that that’s true but the chances of dying for Covid are 80 to 100 times higher if you’re not vaccinated compared to being fully vaccinated, including the booster. There’s also transmission. If a fully vaccinated person does contract Covid, chances are that person will have a lower odds of transmission plus if they do transmit it, chances are the person who receives it will not get as sick. It has to do with viral load. A simple way to explain viral load is that if a person receives just one Covid virus cell, for the most part your immune system will be able to keep up with fighting it. If you receive millions of Covid virus cells at one time, there’s the opposite effect. Dr. John Campbell should be explaining that, not feeding on peoples’ ignorance and getting people killed in the process.
I’m a Republican that’s been doing write-ins for the last six years, but Fox
News is another example of how lies and distortions will get you to the top.
He’s some examples: How Murdoch’s Fox
News allowed Trump's propaganda to destabilize democracy ...Fox
and the Big Lie: Trump returns to campaign trail amid 'stolen election' lawsuits
... Fox & Fiends They say shy people can spot con-artists immediately because they have an uncanny ability to read faces which is the reason they're shy but here's my take on why people can't see through the U.K. nurse:
The following graph is from https://www.nytimes.com/2022/01/31/briefing/boosters-cdc-covid-effectiveness.html. So simple that even a Dr. Campbell cult member and/or anti-vaxxer might understand it. I'm just tired of hearing the argument: "Oh, I know someone that got the vaccine and they still contracted Covid, so why get the vaccine" or that I'm judging people because their ignorance kills. They think their discomfort from the vaccine is more important than saving other peoples’ lives.
Fisetin Longevity Benefits | Mayo Clinic Trials - Dr Brad Stanfield, YouTube
SGLT-2 Inhibitors, GLP1-RAs Show Cardiorenal Event Prevention in Meta-analysis - Medscape, 1/31/22 - "Among three classes of newer antidiabetic drugs, sodium glucose cotransporter-2 (SGLT-2) inhibitors were the most effective for reducing cardiovascular deaths, renal events, and hospitalizations for heart failure (HHF) in patients with or without diabetes" Marijuana Use During Pregnancy Raised Risk of Adverse Neonatal Outcomes - Medscape, 1/28/22 - "Overall, the risk for seven adverse neonatal outcomes was significantly increased among women who were exposed to marijuana during pregnancy, compared with those not exposed. The researchers identified increased risk for birth weight less than 2,500 g (relative risk, 2.06; P = .005), small for gestational age (RR, 1.61; P < .001), preterm delivery (RR, 1.28; P < .001), and NICU admission (RR, 1.38; P < .001). In addition, they found significant differences in mean birth weight (mean difference, −112.30 g; P < .001), Apgar score at 1 minute (mean difference, −0.26; P = .002), and infant head circumference (mean difference, −0.34cm; P = .02) between women who used marijuana during pregnancy and those who did not ... The view among many women that prenatal cannabis use is safe and without consequence "is a false narrative perpetuated by a combination of outdated evidence and recent changes to state-level cannabis policies,"" Flavonoids may reduce mortality risk for people with Parkinson’s Disease - Science Daily, 1/26/22 - "Adding a few servings of flavonoid-rich foods to their diets a week could potentially be an easy way for people with PD to help improve their life expectancy ... Greater consumption of berries and red wine, which are rich in the flavonoid anthocyanins, was particularly associated with lower mortality ... the participants in the group of the highest 25 percent of flavonoid consumers had a 70 percent greater chance of survival than the lowest group ... The people in the highest group consumed about 673 milligrams (mg) of flavonoids each day while those in the lowest group consumed about 134 mg ... The researchers also analyzed the effects of individual flavonoids. They found that those in the top 25 percent consumers of anthocyanins -- found in red wine and berries -- had a 66 percent greater survival rate compared to those in the lowest 25 percent. Additionally, the top 25 percent consumers of flavan-3-ols -- found in apples, tea and wine -- had a 69 percent greater survival rate compared to the lowest 25 percent" - See blueberry extract at Amazon.com. UCSD releases study on cannabis consumption, driving ability - 10News, 1/26/22 - "the THC group displayed significantly diminished ability on a composite drive score that assessed key simulated driving variables such as swerving in the lane, responding to divided attention tasks, and following a lead car. The non-placebo participants smoked a cannabis cigarette with either 5.9% or 13.4% THC ... The study authors said driving scores did not differ based on the THC content of the cigarette. Both the 5.9% and 13.4% groups performed similarly, suggesting that users "self-titrated" by smoking in such a way to achieve similar highness levels" Gut Bacteria Linked With Long COVID - Medscape, 1/25/22 - "the researchers enrolled 106 patients with COVID-19 from February to August 2020, and compared them with people who did not have COVID, recruited in 2019. The severity of COVID in the enrolled patients was mostly mild to moderate ... At 3 months, 86 of the COVID patients had post–acute COVID-19 syndrome (PACS) — defined as at least one persistent, otherwise unexplained symptom 4 weeks after clearance of the virus. And 81 patients had PACS at 6 months, most commonly fatigue, poor memory, hair loss, anxiety, and trouble sleeping ... broadly, the diversity of the types of bacteria, and the abundance of these bacteria, were significantly lower at 6 months for those with PACS, compared with those without PACS and with controls (P < .05 and P < .0001, respectively). Among those with PACS, 28 bacteria species were diminished and 14 were enriched, both at baseline and follow-up. Those patients who had COVID but not PACS showed just 25 alterations of bacteria species at the time of hospital admission, and they all normalized by 6 months ... Having respiratory symptoms at 6 months was linked with higher levels of opportunistic pathogens such as Streptococcus anginosus and S. vestibularis. Neuropsychiatric symptoms and fatigue were associated with nosocomial pathogens that are linked to opportunistic infections, such as Clostridium innocuum and Actinomyces naeslundii ... Bacteria known for producing butyrate, a beneficial fatty acid, were significantly depleted in those patients with hair loss. And certain of these bacteria, including Bifidobacterium pseudocatenulatum and Faecalibacterium prausnitzii, had the largest inverse correlations with PACS at 6 months (P < .05), the researchers found ... Her group is conducting trials to look at how modulating the microbiome might prevent long COVID and boost antibodies after vaccination in high-risk people ... Gut microbiota influences the health of the host ... It provides crucial benefits in the form of immune system development, prevention of infections, nutrient acquisition, and brain and nervous system functionality. Considering the millions of people infected during the ongoing pandemic, our findings are a strong impetus for consideration of microbiota modulation to facilitate timely recovery and reduce the burden of post–acute COVID-19 syndrome" - See probiotic supplements at Amazon.com. My Journey With Intermittent Fasting: What Worked, What Proved Challenging - Medscape, 1/21/22 - "I chose the 16:8 regimen, believing it to be best for a nurse working from home. I fast from 8 PM at night until noon the following day. All food intake is restricted to the hours between noon and 8 PM. Although this method has been less effective in studies of weight loss than the other two, this may have more to do with a lack of guidance regarding caloric intake than with the method of fasting. I have a colleague who faithfully followed the time-restricted method, but he also ate healthfully during the hours of food intake. He exercised during the morning and allowed himself light meals, carefully counting calories during the hours he was allowed to eat. He kept to a regimen of 1200 calories per day ... At the conclusion of 6 weeks, he had lost 22 pounds and gained an immense amount of energy. He reported improved sleep and reduced body aches and pains. This follows what researchers have observed regarding the benefits of intermittent fasting ... The human body was designed to go for prolonged periods without food intake. Our ancestors spent hours hunting for food, often going for extended intervals without nutrition. During periods of fasting, the body can jump-start mechanisms related to glucose consumption, healing, and restoration. Human trials have demonstrated the positive effects of intermittent fasting, which include improvement in chronic health conditions such as diabetes, heart disease, obesity, neurologic disease, and even cancer." Groundbreaking study links grandparents' smoking to your body fat - Hill, 1/21/22 - "It’s potentially one of the first pieces of evidence that human exposure to substances can be passed on to descendants, though researchers have said much more work is needed to understand how that may happen" Magnesium is essential for the immune system, including in the fight against cancer - Science Daily, 1/19/22 - "Magnesium deficiency is associated with a variety of diseases, such as infections and cancer. Previous studies have shown that cancerous growths spread faster in the bodies of mice when the animals received a low-magnesium diet -- and that their defense against flu viruses was also impaired ... T cells can eliminate abnormal or infected cells efficiently only in a magnesium-rich environment. Specifically, magnesium is important for the function of a T cell surface protein called LFA-1 ... The fact that magnesium is essential for the functioning of T cells may be a highly significant finding for modern cancer immunotherapies. These therapies aim to mobilize the immune system -- in particular cytotoxic T cells -- to fight cancer cells. In experimental models, the researchers were able to show that the immune response of T cells against cancer cells was strengthened by an increase in the local magnesium concentration in tumors" - See magnesium supplements at Amazon.com. Calcitriol and Levothyroxine Dosing for Patients With Pseudohypoparathyroidism - Medscape, 1/19/22 - "Current practice guidelines for managing PTH resistance in PHP indicate that providers should use active vitamin D metabolites or analogs with or without oral calcium supplementation to maintain serum levels of calcium and phosphorus within the normal range while avoiding hypercalciuria. Oral calcium supplementation may be needed, as calcium is an under-consumed micronutrient in the average USA diet.[14] Treatment with active vitamin D analogs should be considered when PTH is more than 2 times the upper limit of normal to minimize adverse effects on skeletal and growth plate mineralization.[11,12] Nutritional vitamin D deficiency must be excluded before making a diagnosis of PHP" Could Probiotics Reduce 'Chemo Brain' in Breast Cancer Patients? - Medscape, 1/18/22 - "The finding that probiotic treatment given alongside chemotherapy is sufficient to, in part, protect against memory disturbances in these patients suggests that there may be some neuroprotection conferred by the probiotic treatment" - See probiotic supplements at Amazon.com. Abstracts from this week:
Glycemic,
insulinemic and incretin responses after oral trehalose ingestion in healthy
subjects - Nutr J. 2017; 16: 9 - "Trehalose is
hydrolyzed by a specific intestinal brush-border disaccharidase (trehalase) into
two glucose molecules. In animal studies, trehalose has been shown to prevent
adipocyte hypertrophy and mitigate insulin resistance in mice fed a high-fat
diet. Recently, we found that trehalose improved glucose tolerance in human
subjects ... 20 fasted healthy volunteers consumed 25 g trehalose or glucose in
100 mL water. Blood samples were taken frequently over the following 3 h, and
blood glucose, insulin, active gastric inhibitory polypeptide (GIP) and active
glucagon-like peptide-1 (GLP-1) levels were measure ... Trehalose ingestion did
not evoke rapid increases in blood glucose levels, and had a lower stimulatory
potency of insulin and active GIP secretion compared with glucose ingestion.
Conversely, active GLP-1 showed higher levels from 45 to 180 min after trehalose
ingestion as compared with glucose ingestion. Specifically, active GIP
secretion, which induces fat accumulation, was markedly lower after trehalose
ingestion" - Note: It's a 2017 study but I threw it in because from my
ice cream and pumpkin pie recipes, I've been substituting the sugar with a third
inulin, a third trehalose and a third sugar cane. If anything, it improves the
taste. Plus it's good for the liver. See
trehalose at Amazon.com
Whole-body senescent cell clearance alleviates age-related brain inflammation and cognitive impairment in mice - Aging Cell 2021 Feb - "Cellular senescence is characterized by an irreversible cell cycle arrest and a pro-inflammatory senescence-associated secretory phenotype (SASP), which is a major contributor to aging and age-related diseases. Clearance of senescent cells has been shown to improve brain function in mouse models of neurodegenerative diseases. However, it is still unknown whether senescent cell clearance alleviates cognitive dysfunction during the aging process. To investigate this, we first conducted single-nuclei and single-cell RNA-seq in the hippocampus from young and aged mice. We observed an age-dependent increase in p16Ink4a senescent cells, which was more pronounced in microglia and oligodendrocyte progenitor cells and characterized by a SASP. We then aged INK-ATTAC mice, in which p16Ink4a -positive senescent cells can be genetically eliminated upon treatment with the drug AP20187 and treated them either with AP20187 or with the senolytic cocktail Dasatinib and Quercetin. We observed that both strategies resulted in a decrease in p16Ink4a exclusively in the microglial population, resulting in reduced microglial activation and reduced expression of SASP factors. Importantly, both approaches significantly improved cognitive function in aged mice. Our data provide proof-of-concept for senolytic interventions' being a potential therapeutic avenue for alleviating age-associated cognitive impairment" - See quercetin at Amazon.com.
Association between IGF-1 levels ranges and all-cause mortality: A meta-analysis - Aging Cell 2022 Jan 20 - "with respect to the low IGF-1 category, higher IGF-1 was not associated with increased risk of all-cause mortality (HR = 0.84, 95% CI = 0.68-1.05). Dose-response analysis revealed a U-shaped relation between IGF-1 and mortality HR. Pooled results comparing low vs. middle IGF-1 showed a significant increase of all-cause mortality (HR = 1.33, 95% CI = 1.14-1.57), as well as comparing high vs. middle IGF-1 categories (HR = 1.23, 95% CI = 1.06-1.44). Finally, we provide data on the association between IGF-1 levels and the intake of proteins, carbohydrates, certain vitamins/minerals, and specific foods. Both high and low levels of IGF-1 increase mortality risk, with a specific 120-160 ng/ml range being associated with the lowest mortality. These findings can explain the apparent controversy related to the association between IGF-1 levels and mortality" Metformin maintains intrahepatic triglyceride content through increased hepatic de novo lipogenesis - Eur J Endocrinol 2022 Jan 1 - "intrahepatic triglyceride (IHTG) ... hepatic de novo lipogenesis (DNL) and fatty acid (FA) oxidation ... Twelve weeks treatment with metformin resulted in a significant reduction in body weight and improved insulin sensitivity, but IHTG content and FA oxidation remained unchanged. Metformin treatment was associated with a significant decrease in VLDL-triglyceride (TG) concentrations and a significant increase in the relative contribution of DNL-derived FAs to VLDL-TG. There were subtle and relatively few changes in subcutaneous adipose tissue FA metabolism and the plasma metabolome with metformin treatment" - See metformin at ReliableRX. Metformin ameliorates chronic colitis in a mouse model by regulating interferon-γ-producing lamina propria CD4 + T cells through AMPK activation - FASEB J 2022 Feb - "Metformin, a commonly prescribed drug for type 2 diabetes mellitus, has been shown to activate AMP-activated protein kinase (AMPK). Notably, AMPK activation has recently been observed to be associated with anti-inflammatory responses. Metformin is also reported to elicit anti-inflammatory responses in CD4+ T cells, resulting in improvement in experimental chronic inflammatory diseases, such as systemic lupus erythematosus ... metformin suppresses the frequency of interferon (IFN) -γ-producing LP CD4+ T cells in vitro, which were regulated by AMPK activation, a process possibly induced by the inhibition of oxidative phosphorylation. Furthermore, we examined the effects of metformin on an in vivo IBD model. Metformin-treated mice showed AMPK activation in LP CD4+ T cells and ameliorated colitis. Our study demonstrates that metformin-induced AMPK activation in mucosal CD4+ T cells contributes to the improvement of IBD by suppressing IFN-γ production. Moreover, our results indicate that AMPK may be a target molecule for the regulation of mucosal immunity and inflammation. Thus, AMPK-activating drugs such as metformin may be potential therapeutic agents for the treatment of IBD" - See metformin at ReliableRX. Synergistic Effects of Combined Anthocyanin and Metformin Treatment for Hyperglycemia In Vitro and In Vivo - J Agric Food Chem 2022 Jan 19 - "These results suggest that the use of anthocyanins can enhance the efficacy of metformin treatment for hyperglycemia and provide a reference for further clinical research regarding nutrition and supplementary treatment" - See metformin at ReliableRX and anthocyanins at Amazon.com. Hypoglycemic effects of Rhodiola crenulata (HK. f. et. Thoms) H. Ohba in vitro and in vivo and its ingredient identification by UPLC-triple-TOF/MS - Food Funct 2022 Jan 26 - "Rhodiola crenulata (HK. f. et. Thoms) H. Ohba (RC), mainly distributed in the highly cold region of China, has long been used as a medicine/healthy food for eliminating fatigue and increasing blood circulation ... The results demonstrate that the RCRS extract of Rhodiola crenulata could be employed as a healthy food or medicine for controlling postprandial blood glucose levels" - See Rhodiola crenulata at Amazon.com.
Protective effects of chlorogenic acid on trimethyltin chloride-induced neurobehavioral dysfunctions in mice relying on the gut microbiota - Food Funct 2022 Jan 24 - "Trimethyltin chloride (TMT) is acknowledged to have potent neurotoxicity. Chlorogenic acid (CGA), the most abundant polyphenol in the human diet, is well-known for its neuroprotective activity. This investigation was performed to determine the effects and mechanisms of CGA on TMT-induced neurobehavioral dysfunctions. Mice received oral administrations of CGA (30 mg kg-1) for 11 days, in which they were intraperitoneally injected with TMT (2.7 mg kg-1) once on the 8th day. The daily intake of CGA significantly alleviated TMT-induced epilepsy-like seizure and cognition impairment, ameliorating hippocampal neuronal degeneration and neuroinflammation. Oral gavage of CGA potentially exerted neuroprotective effects through JNK/c-Jun and TLR4/NFκB pathways. Microbiome analysis revealed that daily consumption of CGA raised the relative abundance of Lactobacillus in TMT-treated mice. SCFAs, the gut microbial metabolites associated with neuroprotection, were increased in the mouse hippocampus following CGA treatment. TMT-induced neurotransmitter disorders were regulated by oral gavage of CGA, especially DL-kynurenine and acetylcholine chloride. Additionally, neurotransmitters in the mouse hippocampus were found to be highly associated with the gut microbiota. Our findings provided research evidence for the neuroprotective effect of CGA on TMT-induced neurobehavioral dysfunctions" - See chlorogenic acid at Amazon.com. Ellagic acid enhances muscle endurance by affecting the muscle fiber type, mitochondrial biogenesis and function - Food Funct 2022 Jan 21 - "Ellagic acid (EA) is a natural polyphenolic compound, which shows various effects, such as anti-inflammatory and antioxidant effects and inhibition of platelet aggregation. In this study, we investigated the effect of EA on muscle endurance and explored its possible underlying mechanism. Our data showed that EA significantly improved muscle endurance in mice. EA increased the protein level of slow myosin heavy chain (MyHC) I and decreased the protein level of fast MyHC. We also found that the AMP-activated protein kinase (AMPK) signaling pathway was activated by EA. Finally, our data indicated that EA could increase mitochondrial biogenesis and function by increasing the content of mitochondrial DNA (mtDNA), the concentration of ATP, the activities of succinodehydrogenase (SDH) and malate dehydrogenase (MDH), and the mRNA levels of ATP synthase (ATP5G), mtDNA transcription factor A (TFAM), mitochondrial transcription factor b1 (Tfb1m) and citrate synthase (Cs) in mice and C2C12 myotubes. These results proved that EA could enhance muscle endurance via transforming the muscle fiber type and improving mitochondrial biogenesis and function" - See ellagic acid at Amazon.com.
Alleviation effects of grape seed proanthocyanidin extract on inflammation and oxidative stress in a D-galactose-induced aging mouse model by modulating the gut microbiota - Food Funct 2022 Jan 19 - "Grape seed proanthocyanidin extract (GSPE) that prevents and alleviates the degenerative changes associated with aging has been receiving extensive attention. In our present work, the ageing model was induced by injection of 500 mg kg-1D-galactose daily for a period of eight weeks. The D-galactose-induced ageing mice model was used for evaluating the effect of GSPE on oxidative stress, inflammation levels and gut microbiota composition ... Treatment with different doses of GSPE could significantly improve the antioxidant capacity and inflammation levels in the liver and brain, which is accompanied by increased Lachnospiraceae_NK4A136, Lactobacillus, Bifidobacterium, and Akkermansia, as well as decreased Helicobacter and Alistipes. In addition, the high-dose GSPE group exhibited greater potential to delay the ageing process than the low-dose group. Our results also showed that GSPE administration could downregulate the NLRP3 inflammasome signaling pathway for inhibiting inflammation levels in the brain tissue. This study provided a novel strategy to target the gut microbiota with regard to the effect of GSPE administration on alleviating aging-induced alterations via the gut microbiota-liver axis and gut microbiota-brain axis" - See grape seed extract at Amazon.com. Association Between Plasma L-Carnitine and Cognitive Impairment in Patients with Acute Ischemic Stroke - J Alzheimers Dis 2022 Jan 14 - "L-carnitine has been shown to exert neuroprotective effects on cerebral ischemia, mainly by improving mitochondrial function and reducing inflammation. L-carnitine supplementation has also been promoted to enhance cognitive function ... The study sample population was drawn from the China Antihypertensive Trial in Acute Ischemic Stroke. Plasma L-carnitine were measured at baseline in 617 patients with ischemic stroke using ultrahigh-performance liquid chromatography-tandem mass spectrometry ... Plasma L-carnitine were inversely associated with cognitive impairment at 3 months after ischemic stroke, and the adjusted odds ratio (95% CI) for the highest versus lowest quartiles of L-carnitine was 0.60 (0.37, 0.98; p for trend = 0.04). Each 1-SD increase in log-transformed L-carnitine concentration was significantly associated with a 15% (95% CI: 1%, 29%) reduction in the risk of cognitive impairment after stroke. The addition of L-carnitine to the model including conventional risk factors significantly improved the risk reclassification for cognitive impairment (net reclassification improvement: 17.9%, integrated discrimination improvement: 0.8% ; both p < 0.05). Furthermore, joint effects of L-carnitine and inflammation markers were observed, and patients with higher L-carnitine and a lower inflammatory status simultaneously had the lowest risk of poststroke cognitive impairment" - See L-carnitine at Amazon.com. JOTROL, a Novel Formulation of Resveratrol, Shows Beneficial Effects in the 3xTg-AD Mouse Model - J Alzheimers Dis 2022 Jan 11 - "Alzheimer's disease (AD) has minimally effective treatments currently. High concentrations of resveratrol, a polyphenol antioxidant found in plants, have been reported to affect several AD-related and neuroprotective genes. To address the low bioavailability of resveratrol, we investigated a novel oral formulation of resveratrol, JOTROLTM, that has shown increased pharmacokinetic properties compared to non-formulated resveratrol in animals and in humans ... JOTROL displays significantly increased bioavailability over non-formulated resveratrol. Treatment with JOTROL resulted in AD-related gene expression changes (Adam10, Bace1, Bdnf, Psen1) some of which were brain region-dependent and sex-specific, as well as changes in inflammatory gene and cytokine levels ... JOTROL may be effective as a prophylaxis and/or treatment for AD through increased expression and/or activation of neuroprotective genes, suppression of pro-inflammatory genes, and regulation of central and peripheral cytokine levels" - See resveratrol products at Amazon.com. Reduction in Serum LDL Cholesterol Using a Nutrient Compendium in Hyperlipidemic Adults Unable or Unwilling to Use Statin Therapy: A Double-Blind Randomized Crossover Clinical Trial - J Nutr 2022 Jan 26 - "Many hyperlipidemic patients prescribed β-hydroxy-β-methylglutaryl coenzyme A reductase inhibitors (statins) are unable or unwilling to take them ... This multicenter, randomized, double-blind, free-living crossover study was composed of 2 regimented phases of 4 wk each, separated by a 4-wk washout. Eighteen men and 36 women, with a mean ± SD age of 49 ± 12 y and mean ± SD LDL cholesterol of 131 ± 32.1 mg/dL, were instructed to ingest a variety of ready-to-eat snacks twice daily as a substitute for something they were consuming already. Other behavior changes were actively discouraged. Treatment products provided ≥5 g fiber, 1000 mg ω-3 (n-3) fatty acids, 1000 mg phytosterols, and 1800 μmol antioxidants per serving. Control products were calorie-matched like-items drawn from the general grocery marketplace ... Comparing intervention phase endpoints, LDL cholesterol was reduced a mean ± SD of 8.80 ± 1.69% (P < 0.0001), and TC was reduced a mean ± SD of 5.08 ± 1.12% (P < 0.0001) by treatment foods compared with control foods, whereas effects on other analytes did not differ between treatments. SNPs were not significantly related to outcomes (P ≥ 0.230). Compliance with study foods was 95%" Efficacy of sacubitril/valsartan versus olmesartan in Japanese patients with essential hypertension: a randomized, double-blind, multicenter study - Hypertens Res 2022 Jan 21 - "Patients (n = 1161, aged ≥20 years) with mild to moderate hypertension (mean sitting systolic blood pressure [msSBP] ≥150 to <180 mmHg) were randomized to receive sacubitril/valsartan 200 mg (n = 387), sacubitril/valsartan 400 mg (n = 385), or olmesartan 20 mg (n = 389) once daily for 8 weeks. The primary assessment was a reduction in msSBP from baseline with sacubitril/valsartan 200 mg vs. olmesartan 20 mg at Week 8. Secondary assessments included msSBP reduction with sacubitril/valsartan 400 mg vs. olmesartan at Week 8 and reductions in mean sitting diastolic blood pressure (msDBP), mean sitting pulse pressure (msPP), and overall blood pressure (BP) control rate for all treatment groups at Week 8. Sacubitril/valsartan 200 mg provided a significantly greater reduction in msSBP from baseline than olmesartan at Week 8 (between-treatment difference: -5.01 mmHg [95% confidence interval: -6.95 to -3.06 mmHg, P < 0.001 for noninferiority and superiority]). Greater reductions in msSBP with sacubitril/valsartan 400 mg vs. olmesartan, as well as in msDBP and msPP with both doses of sacubitril/valsartan vs. olmesartan (P < 0.05 for all), were also observed. Patients treated with sacubitril/valsartan achieved an overall higher BP control rate. The safety and tolerability profiles of sacubitril/valsartan were generally comparable to those of olmesartan. The adverse event rate with sacubitril/valsartan was not dose-dependent. Treatment with sacubitril/valsartan was effective and provided superior BP reduction, with a higher proportion of patients achieving target BP goals than treatment with olmesartan in Japanese patients with mild to moderate essential hypertension" Association between dietary intake of polyunsaturated fatty acid and prevalence of hypertension in U.S. adults: A cross-sectional study using data from NHANES 2009-2016 - Hypertens Res 2022 Jan 14 - "This study aimed to evaluate the association between dietary polyunsaturated fatty acid (PUFA) intake and the prevalence of hypertension in U.S. adults. Data from the National Health and Nutrition Examination Survey (NHANES) 2009-2016 were used. Total PUFAs and subtypes of PUFAs, including eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA), docosahexaenoic acid (DHA), alpha-linolenic acid (ALA), linoleic acid (LA), and arachidonic acid (AA), were obtained through two 24 h recalls and adjusted by body weight. Hypertension was defined as the average of three measurements of blood pressure above 130/80 mmHg or taking antihypertensive medication ... Dietary intake of PUFAs was significantly associated with a lower prevalence of hypertension for the highest versus lowest quartiles. The weighted ORs with 95% CIs of hypertension for total PUFA, omega-3 fatty acid, fish oil, ALA, omega-6 fatty acid, LA and AA were 0.47(0.40-0.55), 0.61(0.51-0.72), 0.85(0.74-0.97), 0.65(0.55-0.76), 0.49(0.42-0.58), 0.49(0.42-0.57) and 0.75(0.64-0.89), and the ARDs with 95% CIs were -18.06%(-22.54%, -13.58%), -12.06%(-16.68%, -7.44%), -4.13%(-8.25%, -0.01%), -10.54%(-15.31%, -5.78%), -17.03%(-21.49%, -12.58%), -17.23%(-21.76%, -12.69%) and -6.91%(-11.37%, -2.46%), respectively. Our study proposed that the intake of total PUFAs, omega-3 fatty acids, fish oil, ALA, omega-6 fatty acids, LA, and AA was associated with a lower prevalence of hypertension in the U.S. adults" Can sodium-glucose co-transporter-2 (SGLT-2) inhibitor reduce the risk of adverse complications due to COVID-19? - Targeting hyperinflammation - Curr Med Res Opin 2022 Jan 20 - "Sodium-glucose co-transporter-2 (SGLT-2) inhibitors are antidiabetic drugs with numerous pleiotropic and positive clinical effects, particularly regarding a reno-cardiovascular protective effect. More recent studies, including from our laboratory, have highlighted some novel anti-inflammatory activity of SGLT-2 inhibitors. This may confer a theoretical advantage in mitigating excessive cytokine production and inflammatory response associated with serious COVID-19 infection. Specifically, earlier research has demonstrated that SGLT-2 inhibitors are associated with a notable decrease in inflammatory indicators, for example, C-reactive protein, ferritin, and interleukin-6. Furthermore, SGLT-2 inhibitors exhibit a favourable impact on the vascular endothelium function; this could pertinence the prophylaxis of the thrombotic issues that arise in SARS-CoV-2. This review provides an overview of the COVID-19 indirect immune response mechanisms impacting the cardiovascular system and the possible effect of SGLT-2 inhibitors on the management of COVID-19" - See empagliflozin inhousepharmacy.vu. Glucose-Lowering Medications and Post-Dementia Survival in Patients with Diabetes and Dementia - J Alzheimers Dis 2022 Jan 13 - "glucose-lowering drugs (GLDs) ... Insulin and sulfonylurea carried higher mortality risk among dementia patients, while GLP-1a and SGLT-2i were associated with lower risk. GLD-associated mortality varied between dementia and comparable dementia-free subjects" Melatonin epigenetic potential on testicular functions and fertility profile in varicocele rat model is mediated by Silent information regulator1 - Br J Pharmacol 2022 Jan 21 - "Melatonin treatment of varicocele rats displayed antioxidant/anti-apoptotic efficacy, improved reproductive hormones axis, Catsper expression, fertility parameters. MiR-34a/SIRT1/FOXO1 epigenetic axis integrates testicular melatonin mediated intracellular transduction cascades in varicocele" - See melatonin at Amazon.com.
Orange
Pectin with Compact Conformation Effectively Alleviates Acute
Colitis in Mice - J Agric Food Chem 2022 Jan 26 -
"In this study, we compared the
alleviating effects of five orange pectins (200 mg/kg) extracted
using acid (P2), alkali (P10), cellulase (C), acid + cellulase
(P2 + C), and alkali + cellulase (P10 + C) on dextran sodium
sulfate-induced acute colitis. The physiological and
histopathological indicators revealed that the alleviating
effects were most significant for P10 + C, followed by P10, P2 +
C, P2, and C. P10 + C increased the diversity and relative
abundance of Akkermansia, leading to increased generation of
colonic short-chain fatty acids as well as mRNA and protein
expressions of GPR43, GPR109A, claudin-1, ZO-1, and occludin.
Therefore, proinflammatory cytokines were decreased, and
anti-inflammatory cytokines were increased. A compact
conformation of P10 + C contributed to the alleviation effects
on acute colitis. Alkali + cellulase-extracted orange pectin
with a compact conformation has potential as adjuvant treatment
for intestinal inflammation" - See
Akkermansia at Amazon.com
and
pectin supplements at Amazon.com Lactobacillus plantarum DP189 Reduces α-SYN Aggravation in MPTP-Induced Parkinson's Disease Mice via Regulating Oxidative Damage, Inflammation, and Gut Microbiota Disorder - J Agric Food Chem 2022 Jan 24 - "Our results suggested that L. plantarum DP189 could delay the neurodegeneration caused by the accumulation of α-SYN in the SN of PD mice via suppressing oxidative stress, repressing proinflammatory response, and modulating gut microbiota" - See probiotic supplements at Amazon.com. Gut microbiota in patients with Alzheimer's disease spectrum: a systematic review and meta-analysis - Aging (Albany NY) 2022 Jan 14 - "gut microbiota (GM) ... 11 studies consisting of 378 HC and 427 patients with AD spectrum were included in the meta-analysis. Patients with AD, but not MCI, showed significantly reduced GM diversity as compared to HC. We also found more abundance of Proteobacteria, Bifidobacterium and Phascolarctobacterium, but less abundance of Firmicutes, Clostridiaceae, Lachnospiraceae and Rikenellaceae in patients with AD spectrum as compared with HC. The profiles of abundance of Alistipes and Bacteroides in HC and AD spectrum were differentially affected by countries. Finally, when considering clinical stage as a moderator, the comparisons of abundance in Clostridiaceae and Phascolarctobacterium showed large effect sizes, with gradient changes from MCI to AD stage" - See probiotic supplements at Amazon.com. Chili pepper intake and all-cause and disease-specific mortality - Int J Vitam Nutr Res 2022 Jan 18 - "Chili pepper has been used for the treatment and prevention of multiple diseases. This may be due to its abundance of bioactive components, such as carotenoids, which are well known for their antioxidant properties. To date, several prospective cohort studies have examined the association between chili pepper intake and mortality, but the results have not been consistent. This study aimed to clarify the association between chili pepper intake and all-cause and disease-specific mortality using a meta-analysis ... Compared to none or rare consumption of chili pepper, consumption of chili pepper (ever or more than once a week) could significantly reduce the risk of all-cause mortality (summary adjusted HR: 0.87, 95% CI: 0.85, 0.90), CVD-specific mortality (summary adjusted HR: 0.89, 95% CI: 0.85, 0.93), and cancer-specific mortality (summary adjusted HR: 0.92, 95% CI: 0.88, 0.97). There was no significant between-study heterogeneity in the analyses (all-cause mortality: I2=0.7%, P=0.389; CVD-specific mortality: I2=21.8%, P=0.280; cancer-specific mortality: I2=0.0%, P=0.918)" - See capsicum at Amazon.com. Long-term consumption of a mediterranean diet or a low-fat diet on kidney function in coronary heart disease patients: The CORDIOPREV randomized controlled trial - Clin Nutr 2022 Jan 6 - "The long-term consumption of a Mediterranean diet rich in EVOO, when compared to a low-fat diet, may preserve kidney function, as shown by a reduced decline in eGFR in CHD patients with T2DM. Patients with mildly-impaired eGFR may benefit more from the beneficial effect of the consumption of the Mediterranean diet in preserving kidney function. These findings reinforce the clinical benefits of the Mediterranean diet in the context of secondary cardiovascular disease prevention" - See olive leaf extract at Amazon.com but it could be the omega-9 or both. XENOHORMESIS UNDERLYES THE ANTI-AGING AND HEALTHY PROPERTIES OF OLIVE POLYPHENOLS - Mech Ageing Dev 2022 Jan 13 - "This hormetic framework is applied to the assessment of olive polyphenols with respect to their capacity to slow the onset and reduce the magnitude of a wide range of age-related disorders and neurodegenerative diseases, including Alzheimer's Disease and Parkinson's Disease. It is proposed that olive polyphenol-induced anti-inflammatory protective effects are mediated in large part via the activation of AMPK and the upregulation of Nrf2 pathway. Consistently, herein we also review the importance of the modulation of Nrf2-related stress responsive vitagenes by olive polyphenols, which at low concentration according to the hormesis theory activates this neuroprotective cascade to preserve brain health and its potential use in the prevention and therapy against aging and age-related cognitive disorders in humans" - See olive leaf extract at Amazon.com but it could be the omega-9 or both. Consumption of Olive Oil and Risk of Total and Cause-Specific Mortality Among U.S. Adults - J Am Coll Cardiol 2022 Jan 18 - "During 28 years of follow-up, 36,856 deaths occurred. The multivariable-adjusted pooled HR for all-cause mortality among participants who had the highest consumption of olive oil (>0.5 tablespoon/day or >7 g/d) was 0.81 (95% CI: 0.78-0.84) compared with those who never or rarely consumed olive oil. Higher olive oil intake was associated with 19% lower risk of cardiovascular disease mortality (HR: 0.81; 95% CI: 0.75-0.87), 17% lower risk of cancer mortality (HR: 0.83; 95% CI: 0.78-0.89), 29% lower risk of neurodegenerative disease mortality (HR: 0.71; 95% CI: 0.64-0.78), and 18% lower risk of respiratory disease mortality (HR: 0.82; 95% CI: 0.72-0.93). In substitution analyses, replacing 10 g/d of margarine, butter, mayonnaise, and dairy fat with the equivalent amount of olive oil was associated with 8%-34% lower risk of total and cause-specific mortality" - See olive leaf extract at Amazon.com but it could be the omega-9 or both. Dietary polyphenols and the risk of colorectal cancer in the prospective Southern Community Cohort Study - Am J Clin Nutr 2022 Jan 19 - "Among 71,599 participants, median polyphenol intake was lower for Black individuals [452 mg/day; Interquartile Range (IQR) 277-672 mg/day] than White individuals [958 mg/day; IQR 587-1597 mg/day]. A significant inverse non-linear association was observed for total polyphenol intake with CRC risk (HR = 0.57; CI95% = 0.38, 0.86; P = 0.008 comparing 650 mg/day of intake to 0 mg/day). In addition, inverse linear associations were observed for tyrosols and CRC risk (HRQ5vsQ1 = 0.68; CI95% = 0.50, 0.91; P = 0.0014) and for hydroxybenzoic acids and rectal cancer risk (HRQ5vsQ1 = 0.49; CI95% = 0.29, 0.82; P = 0.0007). Associations were consistent by sex, race, income, and BMI ... Increasing intakes of total polyphenols, tyrosols, and hydroxybenzoic acids were associated with decreased CRC or rectal cancer risk, and associations were consistent across subgroups. Differences in polyphenol intakes may contribute to increased CRC incidence among Black US individuals" - See polyphenols supplements at Amazon.com.
Curcumin suppress inflammatory response in traumatic brain injury via p38/MAPK signaling pathway - Phytother Res 2022 Jan 25 - "We found that curcumin remarkably ameliorated secondary brain injury after TBI, including effects on the neurological severity score and inflammation. After injection of curcumin, the neurological function score of mice decreased significantly. Curcumin exhibited antiinflammatory pharmacological effects, as reflected by inhibition of inflammatory factors (e.g., interleukin [IL]-1β, IL-6, and tumor necrosis factor [TNF]-α). Additionally, curcumin notably reduced the expression of p-p38 according to western blotting and immunohistochemical analyses. In conclusion, curcumin remarkably alleviated posttraumatic inflammation and thus shows potential for treating inflammation associated with TBI" - See curcumin at Amazon.com. An overview of the therapeutic effects of curcumin in reproductive disorders with a focus on the antiinflammatory and immunomodulatory activities - Phytother Res 2022 Jan 18 - "Curcumin, the polyphenolic compound obtained from turmeric, has several pharmacological properties. These properties include antioxidant, antimicrobial, anti-angiogenic, anticarcinogenic, antiinflammatory, and immunomodulatory activities ... Curcumin in the female reproductive system attenuates folliculogenesis, promotes apoptosis of oocytes and blastocyst, and decreases embryo implantation and survival. Curcumin at <100 mg concentration shows protective effects against testicular injury. The concentration of >250 mg of curcumin exhibits immobilizing action on sperms, and at 500 mg concentration completely blocks pregnancy. Curcumin inhibits vaginal infections, attenuates the severity of the premenstrual syndrome, ameliorates inflammatory conditions in polycystic ovary syndrome, improves preeclampsia, and prevents ectopic endometrial lesions. Taken together, curcumin, because of the numerous biological activities, low level of toxicity, and lower adverse effects compared to the synthetic drugs, could be considered as a protective agent for preserving the semen quality parameters, a contraceptive, and chemotherapeutic or chemopreventive agent, as well as an appropriate agent for the treatment of female reproductive disorders" - See curcumin at Amazon.com. Effect of nanocurcumin supplementation on the severity of symptoms and length of hospital stay in patients with COVID-19: A randomized double-blind placebo-controlled trial - Phytother Res 2022 Jan 12 - "This study aimed to determine the effects of nanocurcumin on the severity of symptoms and length of hospital stay (LOS) in COVID-19 patients. Forty-eight COVID-19 patients were randomly assigned into nanocurcumin (n = 24) and placebo (n = 24) groups receiving 160 mg/day nanocurcumin or placebo capsules for 6 days. Mean differences of O2 saturation were significantly higher in patients who received nanocurcumin supplements (p = 0.02). Also, nanocurcumin treatment significantly reduced the scores of domains 3 and 4 and the total score of Wisconsin Upper Respiratory System Survey (WURSS-24), indicating milder symptoms in the treatment group (p = 0.01, 0.03, and 0.01 respectively). Besides, the LOS in curcumin groups was lower than in the placebo group, although the difference was not statistically significant (6.31 ± 5.26 vs. 8.87 ± 8.12 days; p = 0.416). CBC/differentiate, hs-CRP level and the pulmonary involvement in CT scan were not different between the two groups. As nanocurcumin can be effective in increasing O2 saturation and reducing the severity of symptoms in COVID-19 patients, it could probably be used as a complementary agent to accelerate the recovery of patients" - See nano-curcumin at Amazon.com. Antiinflammatory potential of nano-curcumin as an alternative therapeutic agent for the treatment of mild-to-moderate hospitalized COVID-19 patients in a placebo-controlled clinical trial - Phytother Res 2022 Jan 17 - "A total of 60 COVID-19 patients were randomly divided into nano-curcumin and control groups, and then they received 240 mg/day nano-curcumin for 7 days ... The evidence demonstrated that nano-curcumin could be implicated as a complementary medication to act as an antiinflammatory agent and inhibit inflammatory complications" - See nano-curcumin at Amazon.com.
The effect
of sesame, canola, and sesame-canola oils on cardiometabolic
risk factors in overweight adults: a three-way randomized
triple-blind crossover clinical trial - Phytother Res 2022
Jan 23 - "77 overweight adults were
randomized to replace their regularly consumed oils with canola
(CO), sesame (SO), and sesame-canola oils (SCO, 40% SO, and 60%
CO) in three 9-week phases ... SO significantly reduced serum
alkaline aminotransferase (ALT) compared to CO (p ≤ 0.05) in all
participants, increased serum urea compared to SCO in males, and
decreased serum alkaline phosphatase compared to other oils in
males, and improved serum high-density lipoprotein cholesterol
(HDL-C) and triglycerides (TG) compared to SCO, and eGFR
compared with CO in females (p ≤ 0.05). Canola oil significantly
improved serum Apo A1 and APO B/A ratio compared with SO, in
males (p ≤ 0.05). Sesame-canola oil significantly reduced serum
urea compared to other oils in all participants (p ≤ 0.05).
Sesame oil and SCO might beneficially affect serum ALT and urea,
respectively. Intervention oils might have different
cardiometabolic effects in each gender" - See
sesame seed oil at Amazon.com Urolithin A alleviates acute kidney injury induced by renal ischemia reperfusion through the p62-Keap1-Nrf2 signaling pathway - Phytother Res 2022 Jan 17 - "Acute kidney injury (AKI) induced by renal ischemia reperfusion (RIR) is typically observed in renal surgeries and is a leading cause of renal failure ... Herein, we report the effect of Urolithin A (UA) in a mouse RIR model, wherein we demonstrated its underlying mechanism both in vitro and in vivo. The expression levels of p62 and Keap1 significantly decreased, while that of nuclear Nrf2 increased in vitro in a hypoxia cell model after UA treatment. Furthermore, the apoptosis of tubular cells was attenuated and the reactive oxygen species (ROS) levels were reduced in the kidneys in a mouse RIR model after UA administration. In this study, we demonstrated that UA can alleviate oxidative stress and promote autophagy by activating the p62-Keap1-Nrf2 signaling pathway, which could protect the kidneys from ischemia reperfusion injury."
Ginseng in vascular dysfunction: A review of therapeutic potentials and molecular mechanisms - Phytother Res 2022 Jan 13 - "Vascular dysfunction can lead to a variety of fatal diseases, including cardiovascular and cerebrovascular diseases, metabolic syndrome, and cancer. Although a large number of studies have reported the therapeutic effects of natural compounds on vascular-related diseases, ginseng is still the focus of research. Ginseng and its active substances have bioactive effects against different diseases with vascular dysfunction. In this review, we summarized the key molecular mechanisms and signaling pathways of ginseng, its different active ingredients or formula in the prevention and treatment of vascular-related diseases, including cardiac-cerebral vascular diseases, hypertension, diabetes complications, and cancer. Moreover, the bidirectional roles of ginseng in promoting or inhibiting angiogenesis have been highlighted" - See ginseng at Amazon.com. Periodontal disease as a risk factor for sporadic colorectal cancer: results from COLDENT study - Cancer Causes Control 2022 Jan 26 - "the rate of new diagnosis of CRC in persons with a positive history of PD was 1.45 times higher than in those with a negative history of PD adjusting for age, sex, BMI, education, income, diabetes, family history of CRC, regular use of non-steroidal anti-inflammatory drugs, lifetime cumulative smoking, lifetime consumption of red meats, processed meats, and alcoholic drinks, and lifetime total physical activity score" Association of zinc intake with risk of impaired physical function and frailty among older adults - J Gerontol A Biol Sci Med Sci 2022 Jan 16 - "Zinc could be a target nutrient in the prevention of physical impairment and frailty in older adults due to its anti-inflammatory/antioxidant properties ... impaired lower-extremity function (ILEF) ... Higher zinc intake was prospectively associated with a lower risk of ILEF and frailty among older adults, suggesting that adequate zinc intake, that can be achieved through a healthy diet, may help preserve physical function and reduce the progression to frailty" - See zinc supplements at Amazon.com.
U-shaped
association between dietary copper intake and new-onset
hypertension - Clin Nutr 2021 Dec 31 -
"A total of 12,245 participants who were
free of hypertension at baseline from the China Health and
Nutrition Survey (CHNS) were included. Dietary intake was
measured by 3 consecutive 24-h dietary recalls combined with a
household food inventory. New-onset hypertension was defined as
systolic blood pressure ≥140 mmHg and/or diastolic blood
pressure ≥90 mmHg or diagnosed by a physician or under
antihypertensive treatment during the follow-up ... During a
median follow-up of 6.1 years, 4304 participants developed
new-onset hypertension. Overall, the associations between
dietary copper intake and new-onset hypertension followed a
U-shape (P for nonlinearity <0.001). The risk of new-onset
hypertension significantly decreased with the increment of
dietary copper intake (per SD increment: HR, 0.71; 95% CI,
0.57-0.88) in participants with copper intake <1.57 mg/day, and
increased with the increment of dietary copper intake (per SD
increment: HR, 1.09; 95% CI: 1.07-1.12) in participants with
copper intake ≥1.57 mg/day ... There was a U-shaped association
between dietary copper intake and new-onset hypertension in
general Chinese adults, with an inflection point at about 1.57
mg/day. Our results emphasized the importance of maintaining
optimal copper intake levels for the primary prevention of
hypertension" - Note: Zinc supplementation can cause a
copper deficiency. See
Jarrow Zinc Balance at Amazon.com Low folate predicts accelerated cognitive decline: 8-year follow-up of 3140 older adults in Ireland - Eur J Clin Nutr 2022 Jan 13 - "In multivariable-adjusted models of those aged ≥50 years at baseline, low folate at baseline (<11.2 nmol/L) was associated with higher proportions of MMSE errors (incidence rate ratio [IRR] = 1.10; 95% confidence interval [CI] (1.00, 1.21), lowest vs. highest quintile) over 8 years. Plasma folate <21.8 nmol/L predicted declines in episodic memory for immediate (beta [β] = -0.26; 95% CI (-0.48, -0.03), β = -0.29; 95% CI (-0.50, 0.08) and β = -0.29; (-0.50, -0.08), for lowest three vs. highest quintile) and delayed recall (β = -0.20; 95% CI (-0.38, -0.01), β = -0.18; 95% CI (-0.37, -0.01) and β = -0.19; (-0.36, -0.01) lowest three vs. highest quintile)" - See folic acid products at Amazon.com. Associations among FT 4 level, FT 3/FT 4 ratio, and non-alcoholic fatty liver disease in Chinese patients with hypopituitarism - Endocr J 2022 Jan 14 - "The NAFLD(+) group had a significantly higher free triiodothyronine/free thyroxine (FT3/FT4) ratio than the NAFLD(-) group (p = 0.003). The NAFLD(+) group showed significantly lower levels of FT4 and the growth hormone (GH) than the NAFLD(-) group (p = 0.003 and 0.016, respectively). We observed an association of the FT4 level and FT3/FT4 ratio with NAFLD in the univariate model, which was non-significant after adjustment for metabolic parameters (BMI, HDL-C, triglycerides, serum uric acid, blood pressure, fasting glucose). To better understand the role of each metabolic parameters, we performed additional models for each of those predictors individually after adjustment for age and gender, the association between FT4 level and FT3/FT4 ratio lost significance after adjustment for HDL-C and TG, but not for other predictors. Our findings suggest that thyroid dysfunction may be crucially involved in NAFLD by regulating whole-body metabolism, especially lipid utilization. Therefore, sufficient thyroid hormone replacement therapy for patients with hypopituitarism is recommended from the early stage" The effects of oral magnesium supplementation on glycemic control in patients with type 2 diabetes: A systematic review and dose-response meta-analysis of controlled clinical trials - Br J Nutr 2022 Jan 20 - "The dose-response testing indicated that the estimated mean difference in HbA1c at 500 mg/day was -0.73% (95% CI: -1.25, -0.22) suggesting modest improvement in HbA1c with strong evidence [P value: 0.004]. And in FBS at 360 mg/day was -7.11 mg/dL (95% CI: -14.03, -0.19) suggesting minimal amelioration in FBS with weak evidence [P value: 0.092] against the model hypothesis at this sample size. The estimated mean difference in FBS and HbA1c at 24 weeks was -15.58 mg/dL (95%CI: -24.67, -6.49) and -0.48 (95%CI: -0.77, -0.19) respectively, suggesting modest improvement in FBS [P value: 0.034] and HbA1c [P value: 0.001] with strong evidence against the model hypothesis at this sample size" - See magnesium supplements at Amazon.com. Vitexin attenuates non-alcoholic fatty liver disease (NAFLD) lipid accumulation in high fat-diet fed mice by activating autophagy and reducing endoplasmic reticulum (ER) stress in liver - Biol Pharm Bull 2022 Jan 15 - "Non-alcoholic fatty liver disease (NAFLD) has become prevalent worldwide, but sufficient pharmaceutical treatments for this condition are lacking. Previous literature suggests that vitexin offers beneficial effects in the treatment of NAFLD, but the underlying mechanisms are not well understood ... Treatment consisted of four weeks of daily administration of vitexin at a dose of 6 mg/kg of body weight. This treatment markedly improved hepatic architecture, attenuated lipid accumulation, and regulated lipid abnormalities. In addition, the treatment reduced endoplasmic reticulum (ER) stress, restored mitochondrial biological proteins, and increased autophagy. Furthermore, the treatment increased PPAR-r protein, which was inhibited by HFD. Thus, it was speculated that vitexin degraded lipids in HFD-induced NAFLD mice liver by inducing autophagy and restoring both ER and mitochondrial biological proteins" - See vitexin at Amazon.com.
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