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Home > Anti-aging Research > Sesame

Sesame Seed

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News & Research:

  • Sesame & Rice Bran Oil, Yogurt Help Blood Pressure - WebMD, 9/19/12 - "The first study showed a sesame and rice bran oil blend reduced blood pressure almost as well as a commonly used medication. And the second study found that people who routinely eat yogurt are less likely to develop high blood pressure ... In the yogurt study, about 2,000 adults without high blood pressure were followed for 14 years. The researchers found that participants were 31% less likely to develop high blood pressure if more than 2% of their daily calories came from yogurt" - See sesame seed oil at Amazon.com and rice bran oil at Amazon.com.
  • Sesame lignan may help control blood pressure - Nutra USA, 3/31/05 - "sesamin, one of the lignans most abundant in sesame seed and oil, helps to control high blood pressure"


  • Sesamolin Attenuates Kidney Injury, Intestinal Barrier Dysfunction, and Gut Microbiota Imbalance in High-Fat and High-Fructose Diet-Fed Mice - J Agric Food Chem 2023 Jan 11 - "This study investigated the effects of sesamolin on kidney injury, intestinal barrier dysfunction, and gut microbiota imbalance in high-fat and high-fructose (HF-HF) diet-fed mice and explored the underlying correlations among them. The results indicated that sesamolin suppressed metabolic disorders and increased renal function parameters. Histological evaluation showed that sesamolin mitigated renal epithelial cell degeneration and brush border damage ... Thus, sesamolin may be a potential dietary supplement for protection against obesity-associated kidney injury" - See sesame seed oil at Amazon.com.
  • Sesamol Augments Paclitaxel-Induced Apoptosis in Human Cervical Cancer Cell Lines - Nutr Cancer 2022 May 31 - "Sesamol treatment before paclitaxel exposure enhanced the apoptotic cell death in the HeLa cell lines. The results of the present study were in support of the usage of natural medicinal compounds for clinical chemotherapy after systematic animal experimentations"
    • Sesamol - Wikipedia - "Sesamol is a natural organic compound which is a component of sesame seeds and sesame oil. It is a white crystalline solid that is a derivative of phenol" - See sesame seed oil at Amazon.com.
  • The effect of sesame, canola, and sesame-canola oils on cardiometabolic risk factors in overweight adults: a three-way randomized triple-blind crossover clinical trial - Phytother Res 2022 Jan 23 - "77 overweight adults were randomized to replace their regularly consumed oils with canola (CO), sesame (SO), and sesame-canola oils (SCO, 40% SO, and 60% CO) in three 9-week phases ... SO significantly reduced serum alkaline aminotransferase (ALT) compared to CO (p ≤ 0.05) in all participants, increased serum urea compared to SCO in males, and decreased serum alkaline phosphatase compared to other oils in males, and improved serum high-density lipoprotein cholesterol (HDL-C) and triglycerides (TG) compared to SCO, and eGFR compared with CO in females (p ≤ 0.05). Canola oil significantly improved serum Apo A1 and APO B/A ratio compared with SO, in males (p ≤ 0.05). Sesame-canola oil significantly reduced serum urea compared to other oils in all participants (p ≤ 0.05). Sesame oil and SCO might beneficially affect serum ALT and urea, respectively. Intervention oils might have different cardiometabolic effects in each gender"
  • Effects of Dietary Supplementation of Astaxanthin and Sesamin on Daily Fatigue: A Randomized, Double-Blind, Placebo-Controlled, Two-Way Crossover Study - Nutrients. 2018 Feb 28;10(3) - "astaxanthin and sesamin (AS) ... Secondary outcomes included other subjective feelings, work efficiency, autonomic nerve activity, levels of an oxidative stress marker (plasma phosphatidylcholine hydroperoxide (PCOOH)) and safety. AS supplementation was associated with significantly improved recovery from mental fatigue compared with placebo. Increased PCOOH levels during mental and physical tasks were attenuated by AS supplementation. No differences between AS and placebo were detected in secondary outcomes, and no adverse effects of AS supplementation were observed. In conclusion, AS supplementation may be a candidate to promote recovery from mental fatigue which is experienced by many healthy people" - [Nutra USA] - See astaxanthin at Amazon.comand sesamin at Amazon.com.
  • Antihypertensive and antioxidant effects of dietary black sesame meal in pre-hypertensive humans - Nutr J. 2011 Aug 9;10(1):82 - "Twenty-two women and eight men (aged 49.8 +/- 6.6 years) with prehypertension were randomly divided into two groups, 15 subjects per group. They ingested 2.52 g black sesame meal capsules or placebo capsules each day for 4 weeks ... malondialdehyde (MDA) ... The results showed that 4-week administration of black sesame meal significantly decreased systolic BP (129.3 +/- 6.8 vs. 121.0 +/- 9.0 mmHg, P < 0.05) and MDA level (1.8 +/- 0.6 vs. 1.2 +/- 0.6 micromol/L, P < 0.05), and increased vitamin E level (29.4 +/- 6.0 vs. 38.2 +/- 7.8 micromol/L, P < 0.01). In the black sesame meal group, the change in systolic BP tended to be positively related to the change in MDA (R = 0.50, P = 0.05), while the change in diastolic BP was negatively related to the change in vitamin E (R = -0.55, P <0.05)" -  Note:  An 8.3 point drop in systolic seems impressive.  That's about what you get from medication plus it's systolic that most have a problem with.
  • Sesame ingestion affects sex hormones, antioxidant status, and blood lipids in postmenopausal women - J Nutr. 2006 May;136(5):1270-5 - "sesame ingestion benefits postmenopausal women by improving blood lipids, antioxidant status, and possibly sex hormone status"
  • Impact of sesame oil on nifedipine in modulating oxidative stress and electrolytes in hypertensive patients - Asia Pac J Clin Nutr. 2004;13(Suppl):S107 - "The consumption of sesame oil remarkably reduced the (systolic and diastolic blood pressure from 166 +/- 4.2 and 101 +/- 3.1 to 134.2 +/- 3.4 and 84.6 +/- 3.0 respectively) blood pressure"