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Anti-aging Research > Ellagic Acid
Ellagic Acid
Where to purchase:
News & Research:
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Ellagic Acid - ScienceDirect.com - "Ellagic
acid, a polyphenol found in fruits and vegetables including blackberries,
raspberries, strawberries, cranberries, walnuts, pecans, pomegranates,
wolfberry, and other plant foods, is one of the well-studied phytochemical
... Plants form ellagic acids through hydrolysis of tannins (ellagitannin),
and urolithins are microbial metabolites of ellagic acids in humans"
Abstracts:
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Ellagic acid
enhances muscle endurance by affecting the muscle fiber type,
mitochondrial biogenesis and function - Food Funct 2022 Jan
21 - "Ellagic acid (EA) is a natural
polyphenolic compound, which shows various effects, such as
anti-inflammatory and antioxidant effects and inhibition of
platelet aggregation. In this study, we investigated the effect
of EA on muscle endurance and explored its possible underlying
mechanism. Our data showed that EA significantly improved muscle
endurance in mice. EA increased the protein level of slow myosin
heavy chain (MyHC) I and decreased the protein level of fast
MyHC. We also found that the AMP-activated protein kinase (AMPK)
signaling pathway was activated by EA. Finally, our data
indicated that EA could increase mitochondrial biogenesis and
function by increasing the content of mitochondrial DNA (mtDNA),
the concentration of ATP, the activities of succinodehydrogenase
(SDH) and malate dehydrogenase (MDH), and the mRNA levels of ATP
synthase (ATP5G), mtDNA transcription factor A (TFAM),
mitochondrial transcription factor b1 (Tfb1m) and citrate
synthase (Cs) in mice and C2C12 myotubes. These results proved
that EA could enhance muscle endurance via transforming the
muscle fiber type and improving mitochondrial biogenesis and
function" - See
ellagic acid at Amazon.com.
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Urolithin A protects
dopaminergic neurons in experimental models of Parkinson's disease by promoting
mitochondrial biogenesis through the SIRT1/PGC-1α signaling pathway - Food
Funct 2021 Dec 14 - "Mitochondrial dysfunction
contributes to the pathogenesis of neurodegenerative diseases such as
Parkinson's disease (PD). Therapeutic
strategies targeting mitochondrial dysfunction hold considerable promise for the
treatment of PD. Recent reports have highlighted the protective role of
urolithin A (UA), a gut metabolite produced from ellagic acid-containing foods
such as pomegranates, berries and walnuts, in several neurological disorders
including Alzheimer's disease and ischemic stroke ... Our results revealed that
UA protected against 6-OHDA cytotoxicity and apoptosis in PC12 cells. Meanwhile,
administration of UA to 6-OHDA lesioned mice ameliorated both motor deficits and
nigral-striatal dopaminergic neurotoxicity. More important, UA treatment
significantly attenuated 6-OHDA-induced mitochondrial dysfunction in PC12 cells
accompanied by enhanced mitochondrial biogenesis. Mechanistically, we
demonstrated that UA exerts neuroprotective effects by promoting mitochondrial
biogenesis via SIRT1-PGC-1α signaling pathway. Taken together, these data
provide new insights into the novel role of UA in regulating mitochondrial
dysfunction and suggest that UA may have potential therapeutic applications for
PD"
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