To address the growing use of ad blockers we now use affiliate links to sites like Amazon.com, streaming services, and others. Affiliate links help sites like QualityCounts.com stay open. Affiliate links cost you nothing but help me support my family. We do not allow paid reviews on this site. As an Amazon Associate I earn from qualifying purchases.  Also, you can donate  to ben@qualitycounts.com via Zelle or PayPal.  Click here for the PayPal QR.  Click here for Bitcoin QR code or Bitcoin address: 39muDw6WpQV8j6EdA8eUBvT5iFDiVpVpiE
Home ReliableRXPharmacy Past Newsletters Amazon.com Contact
 Sign-up for newsletter 
 Newsletter Archive
 Newsletter via RSS Feed
 Research on Supplements
 Health Conditions
 Anti-aging Recommendations
 Insulin and Aging
 QualityCounts.com in Time
 Longevity Affiliates:

Home > Anti-aging Research > Ellagic Acid

Ellagic Acid

Where to purchase:

News & Research:

  • Ellagic Acid - ScienceDirect.com - "Ellagic acid, a polyphenol found in fruits and vegetables including blackberries, raspberries, strawberries, cranberries, walnuts, pecans, pomegranates, wolfberry, and other plant foods, is one of the well-studied phytochemical ... Plants form ellagic acids through hydrolysis of tannins (ellagitannin), and urolithins are microbial metabolites of ellagic acids in humans"


  • Ellagic acid enhances muscle endurance by affecting the muscle fiber type, mitochondrial biogenesis and function - Food Funct 2022 Jan 21 - "Ellagic acid (EA) is a natural polyphenolic compound, which shows various effects, such as anti-inflammatory and antioxidant effects and inhibition of platelet aggregation. In this study, we investigated the effect of EA on muscle endurance and explored its possible underlying mechanism. Our data showed that EA significantly improved muscle endurance in mice. EA increased the protein level of slow myosin heavy chain (MyHC) I and decreased the protein level of fast MyHC. We also found that the AMP-activated protein kinase (AMPK) signaling pathway was activated by EA. Finally, our data indicated that EA could increase mitochondrial biogenesis and function by increasing the content of mitochondrial DNA (mtDNA), the concentration of ATP, the activities of succinodehydrogenase (SDH) and malate dehydrogenase (MDH), and the mRNA levels of ATP synthase (ATP5G), mtDNA transcription factor A (TFAM), mitochondrial transcription factor b1 (Tfb1m) and citrate synthase (Cs) in mice and C2C12 myotubes. These results proved that EA could enhance muscle endurance via transforming the muscle fiber type and improving mitochondrial biogenesis and function" - See ellagic acid at Amazon.com.
  • Urolithin A protects dopaminergic neurons in experimental models of Parkinson's disease by promoting mitochondrial biogenesis through the SIRT1/PGC-1α signaling pathway - Food Funct 2021 Dec 14 - "Mitochondrial dysfunction contributes to the pathogenesis of neurodegenerative diseases such as Parkinson's disease (PD). Therapeutic strategies targeting mitochondrial dysfunction hold considerable promise for the treatment of PD. Recent reports have highlighted the protective role of urolithin A (UA), a gut metabolite produced from ellagic acid-containing foods such as pomegranates, berries and walnuts, in several neurological disorders including Alzheimer's disease and ischemic stroke ... Our results revealed that UA protected against 6-OHDA cytotoxicity and apoptosis in PC12 cells. Meanwhile, administration of UA to 6-OHDA lesioned mice ameliorated both motor deficits and nigral-striatal dopaminergic neurotoxicity. More important, UA treatment significantly attenuated 6-OHDA-induced mitochondrial dysfunction in PC12 cells accompanied by enhanced mitochondrial biogenesis. Mechanistically, we demonstrated that UA exerts neuroprotective effects by promoting mitochondrial biogenesis via SIRT1-PGC-1α signaling pathway. Taken together, these data provide new insights into the novel role of UA in regulating mitochondrial dysfunction and suggest that UA may have potential therapeutic applications for PD"