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Recent Longevity News for the seven days ending 8/12/09.  You should consult your doctor if you are taking any medications.

Aspirin May Help Treat Colon Cancer - WebMD, 8/10/09 - "Certain patients with colorectal cancer who begin regular aspirin use after the disease develops may greatly improve their odds of survival ... Patients with colorectal cancer who started regular aspirin use for the first time after diagnosis had a 47% lower risk of colorectal cancer death and 32% lower risk of overall death than nonusers of aspirin ... The survival advantage was seen only in those with Cox-2-positive tumors. Most colorectal tumors are Cox-2-positive"

Hot Flash: Low Testosterone Robs Men of Joy, Sex, Energy - ABC  News, 8/10/09 - "By the time Dan hit 57, he didn't recognize himself. He was always tired, fell asleep after dinner and was angry all the time ... "After a year, the injections worked," Dan said. "It's not like I am doing physical feats that I was not doing before, but I was noticing a change when I would take groceries out of the car and move wood into the pile. Before, I used to groan as I did it and had more aches and pains.""

Sedentary Lives Can Be Deadly: Physical Inactivity Poses Greatest Health Risk To Americans, Expert Says - Science Daily, 8/10/09 - "Blair is a professor of exercise science and epidemiology at the University of South Carolina's Arnold School of Public Health. He is one of the world's premier experts on exercise and its health benefits and was the senior scientific editor of the 1996 U.S. Surgeon General's Report on Physical Activity and Health ... approximately 25 percent to 35 percent of American adults are inactive ... meaning that they have sedentary jobs, no regular physical activity program and are generally inactive around the house or yard ... these individuals are doubling their risk of developing numerous health conditions compared with those who are even moderately active and fit ... moderately fit men lived six years longer than unfit men ... Blair also highlighted the benefits of exercise on the mind, referring to recent emerging evidence that activity delays the mind's decline and is good for brain health overall"

Why Exercise Won't Make You Thin - Time Magazine, 8/9/09 - "Many obesity researchers now believe that very frequent, low-level physical activity — the kind humans did for tens of thousands of years before the leaf blower was invented — may actually work better for us than the occasional bouts of exercise you get as a gym rat ... You cannot sit still all day long and then have 30 minutes of exercise without producing stress on the muscles ... The muscles will ache, and you may not want to move after. But to burn calories, the muscle movements don't have to be extreme. It would be better to distribute the movements throughout the day"

Stress Raises Belly Fat, Heart Risks - WebMD, 8/6/09 - "Even compared to other monkeys with the same body mass index and weight, CT scans showed that the stressed monkeys had a great deal more belly fat. And when the researchers looked at the animals' arteries, they found plaque clogging the arteries of the stressed monkeys ... it's not how much fat you have, but where it is located ... Over time, high cortisol levels cause belly fat to accumulate. It also makes individual fat cells get larger ... When you have lots more fat in visceral fat cells and all the characteristics of the metabolic syndrome, each of these things promotes atherosclerosis"

Green tea extracts linked to healthier bones: Study - Nutra USA, 8/6/09 - "EGC was found to stimulate bone mineralisation, while simultaneously inhibiting the formation of osteoclasts. The other catechins were found to have a significantly weaker effect ... “The present study illustrated that the tea catechins, EGC in particular, had positive effects on bone metabolism through a double process of promoting osteoblastic activity and inhibiting osteoclast differentiations" - [Abstract] - See green tea extract at Amazon.com.

Popular Insect Repellent Deet Is Neurotoxic - Science Daily, 8/4/09 - "The active ingredient in many insect repellents, deet, has been found to be toxic to the central nervous system"

Abstracts from this week's Doctor's Guide Nutrition/Dietetics plus abstracts from my RSS feeds (Click here for the journals, the PubMed ones at the top):

Higher sea fish intake is associated with greater bone mass and lower osteoporosis risk in postmenopausal Chinese women - Osteoporos Int. 2009 Aug 6 - "After adjusting for the potential confounders, we observed dose-dependent relations between sea fish intake and BMDs, BMCs, and osteoporosis risk; the mean BMDs were 3.2-6.8% higher, and BMCs 5.1-9.4% higher in the top quintile groups (Q5) of sea fish intake than in the bottom quintile (Q1) at the whole body and hip sites (p < 0.05); the odds ratios (95% confidence interval (CI)) for osteoporosis (T-score < -2.5) in Q5 were 0.23 (0.08-0.66), 0.12 (0.03-0.59), and 0.06 (0.01-0.44) compared with those in Q1 at the whole body, total hip, and femur neck, respectively. No independent association between consumption of freshwater fish or shellfish and bone mass was observed ... Higher intake of sea fish is independently associated with greater bone mass and lower osteoporosis risk among postmenopausal Chinese women" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.

Omega-3 polyunsaturated fatty acids and cardiovascular diseases - J Am Coll Cardiol. 2009 Aug 11;54(7):585-94 - "The most compelling evidence for CV benefits of omega-3 PUFA comes from 4 controlled trials of nearly 40,000 participants randomized to receive eicosapentaenoic acid (EPA) with or without docosahexaenoic acid (DHA) in studies of patients in primary prevention, after myocardial infarction, and most recently, with heart failure (HF) ... The target EPA + DHA consumption should be at least 500 mg/day for individuals without underlying overt CV disease and at least 800 to 1,000 mg/day for individuals with known coronary heart disease and HF" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.

Lower serum testosterone is independently associated with insulin resistance in non-diabetic older men. The Health In Men Study - Eur J Endocrinol. 2009 Aug 6 - "In older men, lower total testosterone is associated with insulin resistance independently of measures of central obesity. This association is seen with testosterone levels in the low to normal range. Further studies are needed to evaluate interventions which raise testosterone levels in men with reduced insulin sensitivity"

Effect of vitamin D supplementation on serum 25-hydroxy vitamin D levels, joint pain, and fatigue in women starting adjuvant letrozole treatment for breast cancer - Breast Cancer Res Treat. 2009 Aug 5 - "Vitamin D deficiency and insufficiency may contribute to musculoskeletal symptoms and bone loss observed in women taking aromatase inhibitors (AIs) ... After 16 weeks of letrozole, more women with 25OHD levels >66 ng/ml (median level) reported no disability from joint pain than did women with levels <66 ng/ml (52 vs. 19%; P = 0.026). Vitamin D deficiency and insufficiency are prevalent in post-menopausal women initiating adjuvant AI. Vitamin D3 supplementation with 50,000 IU per week is safe, significantly increases 25OHD levels, and may reduce disability from AI-induced arthralgias" - See vitamin D at Amazon.com.

Green Tea (-)-Epigallocatechin-3-Gallate Inhibits {beta}-Amyloid-Induced Cognitive Dysfunction through Modification of Secretase Activity via Inhibition of ERK and NF-{kappa}B Pathways in Mice - J Nutr. 2009 Aug 5 - "Compared with untreated mutant PS2 AD mice, treatment with EGCG enhanced memory function and brain alpha-secretase activity but reduced brain beta- and gamma-secretase activities as well as Abeta levels. Moreover, EGCG inhibited the fibrillization of Abeta in vitro with a half maximal inhibitory concentration of 7.5 mg/L. These studies suggest that EGCG may be a beneficial agent in the prevention of development or progression of AD" - See green tea extract at Amazon.com.

Effect of melatonin, captopril, spironolactone and simvastatin on blood pressure and left ventricular remodelling in spontaneously hypertensive rats - J Hypertens. 2009 Aug;27 Suppl 6:S5-10 - "It is concluded that although melatonin, in comparison with captopril, did not reverse left ventricle hypertrophy, it reversed left ventricular fibrosis. This protection by melatonin may be caused by its prominent antioxidative effect" - See melatonin at Amazon.com.

The circadian melatonin rhythm and its modulation: possible impact on hypertension - J Hypertens. 2009 Aug;27 Suppl 6:S17-20 - "The chronic administration of melatonin to individuals with hypertension induces a measurable drop in night time systolic and diastolic blood pressure. Moreover, the higher the night time level of endogenous melatonin (estimated from urinary metabolite of melatonin, 6-hydroxymelatonin sulphate), the greater the reduction in arterial blood pressure at night. The implication of these findings is that melatonin may have utility as an antihypertensive agent" - See melatonin at Amazon.com.

Effects of Tea Catechins, Epigallocatechin, Gallocatechin, and Gallocatechin Gallate, on Bone Metabolism - J Agric Food Chem. 2009 Aug 4 - "The present study illustrated that the tea catechins, EGC in particular, had positive effects on bone metabolism through a double process of promoting osteoblastic activity and inhibiting osteoclast differentiations" - See green tea extract at Amazon.com.

Metformin use and prostate cancer in Caucasian men: results from a population-based case-control study - Cancer Causes Control. 2009 Aug 4 - "In Caucasian men, metformin use was more common in controls than in cases (4.7 vs. 2.8%, p = 0.04), resulting in a 44% risk reduction for PCa (adjusted OR = 0.56; 95% CI 0.32-1.00). No association was seen in African-American men" - See metformin at IAS.

Legume intake and the risk of cancer: a multisite case-control study in Uruguay - Cancer Causes Control. 2009 Aug 4 - "Higher intake of legumes was associated with a decreased risk of several cancers including those of the upper aerodigestive tract, stomach, colorectum, and kidney, but not lung, breast, prostate or bladder"

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