Recent Longevity News for the seven days ending 12/5/12. You should consult your doctor if you are taking any medications.
Diabetes Risk Linked to Low Vitamin D Levels - Medscape, 12/3/12 - "Low serum vitamin D concentration was associated with an increased risk of developing "insulin-requiring" diabetes in a nested case-control study of active-duty military service members ... Those in the lowest quintile of serum 25(OH)D levels (<43 nmol/L) had a 3.5-fold greater likelihood of developing insulin-requiring diabetes than those in the highest quintile of serum 25(OH)D levels (≥100 nmol/L). Those in the second-lowest quintile of serum 25(OH)D levels (43 - 59 nmol/l) had a 2.5-fold greater risk ... It is possible, the researchers state, that vitamin D affects immune function" - See vitamin D at Amazon.com.
Losartan Improves Erectile Dysfunction in Diabetic Patients - Medscape, 12/3/12 - "In this study, we found that diabetic patients suffering from ED were responsive to the losartan treatment. The IIEF-5 scores, the percentage of positive answers to the SEP-2, SEP-3 and GAQ after treatment are all significantly increased as compared with baseline and the end point of control groups. The analysis of our study also indicated that losartan worked better in mild and moderate ED than severe cases. It is consistent with our previous studies, which shows that losartan can downregulate the local expression of AT1 and Ang II, but it cannot elevate the reduced smooth muscle/collagen ratio in diabetic rats [7,8] We believe that the losartan may not completely reverse the severe damaged penile tissues due to diabetes" - Note: It says that's the first study in diabetics but I've read several studies over the years supporting losartan and ED. See my ARB page. It would seem that it would extend to the entire ARB class of antihypertensives but I haven't seen studies on that. See losartan (Cozaar) OffshoreRx1.com.
Treating gum disease may fix erection troubles, too, study finds - nbcnews.com, 12/3/12 - "The study involved 120 patients with severe or moderate erectile dysfunction and chronic periodontitis. Half received treatment for their gum disease, while half did not. They filled out questionnaires about their erectile function, and patients who received treatment for their gum disease reported that levels of erectile function improved after three months ... I feel that the causal element is probably vascular disease, poor general health status, lack of medical attention (gum disease), underlying diabetes/hypertension, or all of the above"
Why older adults become fraud victims more often - Science Daily, 12/3/12 - "The older adults do not have as strong an anterior insula early-warning signal; their brains are not saying 'be wary,' as the brains of the younger adults are"
Top 7 Germiest Public Places - ABC News, 12/3/12 - "Restaurant Menus ... Lemon Wedges ... Condiment Dispensers ... Restroom Door Handles ... Soap Dispensers ... Airplane Bathrooms ... Doctor's Office"
Diabetes Drug Metformin May Fight Cancer - WebMD, 12/3/12 - "The study is just one of dozens under way worldwide examining the drug -- which costs just pennies a pill -- as a treatment for breast, colon, prostate, pancreatic, and ovarian cancers ... After five years, 67% of women who took metformin had not died from ovarian cancer, compared to 47% of women without diabetes who did not take the drug ... The survival difference in the two groups was striking ... Every way we looked at this, the metformin group always did better ... If metformin really does fight cancer, it may do so by lowering circulating insulin levels in the blood" - [Science Daily] - See metformin at IAS.
Vitamin D tied to women's cognitive performance - Science Daily, 11/30/12 - "Higher vitamin D dietary intake is associated with a lower risk of developing Alzheimer's disease ... low vitamin D levels among older women are associated with higher odds of global cognitive impairment and a higher risk of global cognitive decline ... Slinin's group based its analysis on 6,257 community-dwelling older women who had vitamin D levels measured during the Study of Osteopathic Fractures" - See vitamin D at Amazon.com.
Finger Length a Marker of Verbal Aggression? - Medscape, 11/30/12 - "Those who had smaller 2D:4D ratios, which correlates with prenatal exposure to testosterone, reported more verbal aggression behaviors than did the participants with higher ratios ... prenatal androgen exposure (PNAE) ... Most importantly, data indicate that 2D:4D is a proxy for sex hormones levels at the time of brain organization ... The ratio did not correlate with either argumentativeness or openness to other experiences"
NSAID use linked to reduced hepatocellular carcinoma risk and mortality due to chronic liver disease - Science Daily, 11/28/12 - "Hepatocellular carcinoma (HCC), the most common type of primary liver cancer, occurs mainly among patients with CLD ... performed an observational study of 300,504 men and women aged 50 to 71 years enrolled in the National Institutes of Health-AARP Diet and Health Study who reported their aspirin and nonaspirin NSAID use and were followed-up for 10-12 years ... Study participants who used aspirin had a 41% reduced risk of HCC and a 45% reduced risk of death from CLD, whereas those who used non-aspirin NSAIDs experienced a 26% reduced risk of CLD mortality but no reduced risk of HCC" - [Abstract]
'Chemo brain': Researchers identify physiological evidence of chemotherapy-induced changes in the brain - Science Daily, 11/27/12 - "When we looked at the results, we were surprised at how obvious the changes were ... PET/CT results demonstrated statistically significant decreases in regional brain metabolism that were closely associated with symptoms of chemo brain phenomenon ... The study shows that there are specific areas of the brain that use less energy following chemotherapy ... Research has already shown that patients with chemo brain can benefit from the assistance of nutritionists, exercise therapists, massage therapists and counselors"
Potentially toxic flame retardants found in many US couches - Science Daily, 11/28/12 - "Tris was phased out from use in baby pajamas back in 1977 because of its health risks, but it still showed up in 41 percent of the couch foam samples we tested ... analyzed 102 polyurethane foam samples from couches purchased for home use in the United States between 1985 and 2010 ... In addition to finding Tris, the tests revealed that 17 percent of the foam samples contained the flame-retardant pentaBDE, which is banned in 172 countries and 12 U.S. states and was voluntarily phased out by U.S manufacturers in 2005 ... PentaBDEs are long-lasting chemicals that over time migrate into the environment and accumulate in living organisms. Studies show they can disrupt endocrine activity and affect thyroid regulation and brain development. Early exposure to them has been linked to low birth weight, lowered IQ and impaired motor and behavioral development in children"
Many flame retardants in house dust at unsafe levels - Science Daily, 11/28/12 - "Forty-four flame retardant chemicals were detected and 36 were found in at least 50% of the samples, sometimes at levels of health concern. The flame retardants found in house dust are in furniture, textiles, electronics, and other products and include hormone disruptors, carcinogens, and chemicals with unknown safety profiles ... This study complements a separate study, also being published in Environmental Science & Technology on Nov. 28, that found many potentially problematic flame retardants in couches ... When one toxic flame retardant is phased out, it's being replaced by another chemical we either know is dangerous or suspect may be"
Breast cancer risk estimates increased with repeated prior CT and nuclear imaging - Science Daily, 11/27/12 - "Young women receiving several chest and or cardiac CTs had the greatest increased risk of developing breast cancer at approximately 20 percent ... A 15-year-old girl with no risk factors for breast cancer would double her 10-year risk of developing breast cancer at 25"
Glucosamine, Chondroitin, Fish Oil May Reduce Inflammation - Medscape, 11/27/12 - "Inflammation is now recognized as a factor in cancer and cardiovascular disease as well as many rheumatoid diseases ... the researchers found hs-CRP reductions of 17% (95% confidence interval [CI], 7% - 26%) with glucosamine, 22% (95% CI, 8% - 33%) with chondroitin, and 16% (95% CI, 0.3% - 29%) with fish oil compared with participants who did not take the supplements" - See glucosamine products at Amazon.com, chondroitin sulfate at Amazon.com, Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
Vitamin D linked to lower rates of tooth decay - Science Daily, 11/27/12 - "The review, published in the December issue of Nutrition Reviews, encompassed 24 controlled clinical trials, spanning the 1920s to the 1980s, on approximately 3,000 children in several countries. These trials showed that vitamin D was associated with an approximately 50 percent reduction in the incidence of tooth decay" - See vitamin D at Amazon.com.
White rice consumption and risk of type 2 diabetes - Clin Nutr. 2012 Nov 14 - "A population-based cohort study was undertaken in Pizarra, Spain. At baseline and follow-up, participants underwent an interview and a standardized clinical examination which included an oral glucose tolerance test in those subjects without known diabetes ... In subjects who reported rice intake 2-3 times a week, incidence of diabetes after 6 years follow-up was 12.0%, and in those who reported once or less a week, 20.2% (p = 0.04, non adjusted). Subjects who ate rice frequently had lower risk to develop diabetes 6 years later (OR = 0.43, p = 0.04; adjusted for age, sex, obesity, and presence of impaired fasting glucose and/or impaired glucose tolerance at baseline)"
Changes in bread consumption and 4-year changes in adiposity in Spanish subjects at high cardiovascular risk - Br J Nutr. 2012 Dec 3:1-10 - "We analysed 2213 participants at high risk for CVD from the PREvención con DIeta MEDiterránea (PREDIMED) trial to assess the association between changes in the consumption of bread and weight and waist circumference gain over time. Dietary habits were assessed with validated FFQ at baseline and repeatedly every year during 4 years of follow-up ... The present results showed that over 4 years, participants in the highest quartile of change in white bread intake gained 0.76 kg [1.7 pounds] more than those in the lowest quartile (P for trend = 0.003) and 1.28 cm [0.5 inches] more than those in the lowest quartile (P for trend < 0.001) ... The present results suggest that reducing white bread, but not whole-grain bread consumption, within a Mediterranean-style food pattern setting is associated with lower gains in weight and abdominal fat"
Effects of EPA, γ-linolenic acid or coenzyme Q10 on serum prostate-specific antigen levels: a randomised, double-blind trial - Br J Nutr. 2012 Nov 30:1-8 - "A total of 504 healthy men with serum PSA level ≤ 2.5 ng/ml were recruited into the study ... Participants were randomly assigned to a daily dietary supplement containing n-3 fatty acids (1.12 g of EPA and 0.72 g of DHA per capsule) (group 1, n 126), n-6 fatty acid (600 mg γ-linolenic acid (GLA) each capsule) (group 2, n 126), CoQ10 (100 mg per capsule) (group 3, n 126) or a similar regimen of placebo (group 4, n 126) for 12 weeks ... EPA treatment significantly reduced serum PSA level by 30.0 (95 % CI 25, 36) % (P = 0.004) from baseline. In contrast, GLA therapy significantly increased serum PSA concentration by 15.0 (95 % CI 11, 20) % (P = 0.02). CoQ10 therapy also significantly reduced serum PSA level by 33.0 (95 % CI 27, 40) % (P = 0.002). In multivariable analysis, serum values of PSA were strongly correlated with duration of EPA (r - 0.62; 95 % CI - 0.42, - 0.77; P = 0.003), n-6 (r 0.42; 95 % CI 0.31, 0.58; P = 0.02) and CoQ10 use (r - 0.77; 95 % CI - 0.56, - 0.87; P = 0.001). There were also significant correlations between serum values of DHA, EPA, GLA and CoQ10 and serum PSA levels. The present study demonstrates that dietary supplements containing EPA, GLA or CoQ10 may significantly affect serum PSA levels" - See ubiquinol products at Amazon.com and Mega Twin EPA at Amazon.com.
Intake of specific nutrients and foods and hearing level measured 13 years later - Br J Nutr. 2012 Nov 19:1-10 - "hearing level (HL) ... We examined the 13-year association between intake of specific nutrients and food groups and HL in a sample of French adults ... Intakes of retinol (P-trend = 0.058) and vitamin B12 (P-trend = 0.068) tended to be associated with better HL in women. Intakes of meat as a whole (P-trend = 0.030), red meat (P-trend = 0.014) and organ meat (P-trend = 0.017) were associated with better HL in women. Higher intake of seafood as a whole (P-trend = 0.07) and of shellfish (P-trend = 0.097) tended to be associated with better HL in men. Consumption of meat is therefore associated with a better HL in women"
Metformin and reduced risk of hepatocellular carcinoma in diabetic patients: a meta-analysis - Scand J Gastroenterol. 2012 Nov 9 - "Medline and Embase databases were searched to identify the relevant studies between January 1966 and December 2011 ... the overall prevalence of HCC was 3.40% (562/16,549) in DM patients. The overall analysis showed a significantly reduced risk of HCC in metformin users versus nonusers in diabetic patients (relative risk (RR) 0.24, 95% confidence interval (CI) 0.13-0.46, p < 0.001)" - See metformin at IAS.
Vitamin D reduces left atrial volume in patients with left ventricular hypertrophy and chronic kidney disease - Am Heart J. 2012 Dec;164(6):902-909.e2 - "Left atrial enlargement, a sensitive integrator of left ventricular diastolic function, is associated with increased cardiovascular morbidity and mortality ... left atrial volume index (LAVi) ... One hundred ninety-six patients with chronic kidney disease (estimated glomerular filtration rate 15-60 mL/min per 1.73m(2)), mild to moderate left ventricular hypertrophy, and preserved ejection fraction were randomly assigned to 2 μg of oral paricalcitol or matching placebo for 48 weeks ... Over the study period, there was a significant decrease in LAVi (-2.79 mL/m(2), 95% CI -4.00 to -1.59 mL/m(2)) in the paricalcitol group compared with the placebo group (-0.70 mL/m(2) [95% CI -1.93 to 0.53 mL/m(2)], P = .002). Paricalcitol also attenuated the rise in levels of brain natriuretic peptide (10.8% in paricalcitol vs 21.3% in placebo, P = .02) ... Forty-eight weeks of therapy with an active vitamin D analog reduces LAVi and attenuates the rise of BNP. In a population where only few therapies alter cardiovascular related morbidity and mortality, these post hoc results warrant further confirmation" - See vitamin D at Amazon.com.
Effect of omega-3 (n-3) fatty acid supplementation in patients with sickle cell anemia: randomized, double-blind, placebo-controlled trial - Am J Clin Nutr. 2012 Nov 28 - "Blood cell aggregation and adherence to vascular endothelium and inflammation play a central role in vaso-occlusive crisis in sickle cell disease. The antiaggregatory, antiadhesive, antiinflammatory, and vasodilatory omega-3 (n-3) fatty acids (DHA and EPA) are significantly reduced in patients with the disease ... One hundred forty patients recruited from a single center in Sudan were randomly assigned and received, daily, 1 (age 2-4 y), 2 (age 5-10 y), 3 (age 11-16), or 4 (age ≥17 y) omega-3 capsules containing 277.8 mg DHA and 39.0 mg EPA or placebo for 1 y ... Omega-3 treatment reduced the median rate of clinical vaso-occlusive events (0 compared with 1.0 per year, P < 0.0001), severe anemia (3.2% compared with 16.4%; P < 0.05), blood transfusion (4.5% compared with 16.4%; P < 0.05), white blood cell count (14.4 +/- 3.3 compared with 15.6 +/- 4.0 ×10(3)/μL; P < 0.05), and the OR of the inability to attend school at least once during the study period because of illness related to the disease to 0.4 ... The findings of this trial, which need to be verified in a large multicenter study, suggest that omega-3 fatty acids can be an effective, safe, and affordable therapy for sickle cell anemia" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
Serum 25-hydroxyvitamin D and risk of major osteoporotic fractures in older U.S. adults - J Bone Miner Res. 2012 Nov 26 - "The study used a pooled cohort of 4749 men and women ages 65 years and older from the third National Health and Nutrition Examination Survey (NHANES III, 1988-94) and NHANES 2000-2004 ... Serum 25OHD was a significant linear predictor of major osteoporotic fracture and significant quadratic predictor of hip fracture in the total sample and among those with less than 10 years of follow-up, but it was not related to risk of either fracture type among those with > 10 years of follow-up. Major osteoporotic fracture risk was increased by 26-27% for each SD decrease in serum 25OHD among those with less than 10 years of follow-up. Serum 25OHD was significantly related to risk of major osteoporotic fractures as a group and to hip fracture alone in this cohort of older US adults from NHANES III and NHANES 2000-2004. However, the predictive utility of serum 25OHD diminished after ten years. In addition, the relationship appeared to be linear when major osteoporotic fracture risk was considered but quadratic when hip fracture risk was assessed" - See vitamin D at Amazon.com.
High physical fitness in young adulthood reduces the risk of fractures later in life in men: A nationwide cohort study - J Bone Miner Res. 2012 Nov 26 - "Aerobic capacity and isometric muscle strength were measured in 435445 Swedish men that conscripted for military service from 1969-1978 ... When comparing men in the lowest and highest decile of physical fitness, the risk of a fracture was 1.8 times higher (95% CI = 1.6-2.1) and that of hip fracture was 2.7 times higher (95% CI = 1.6-4.7). The risk of fracture was also 1.4-1.5 times higher when comparing the extreme deciles of muscle strength (p < 0.001 for all). In a subcohort of 1009 twin pairs, up to 22% of the variation in physical fitness and 27-39% of the variation in muscle strength was attributable to environmental factors unique to one twin, e.g. physical activity. In conclusion, low aerobic capacity and muscle strength in young adulthood are associated with an increased risk of low-energy fractures later in life, while a low-energy fracture is associated with an increased risk of death already in middle-aged men"
Increased arterial stiffness in subjects with impaired fasting glucose - J Diabetes Complications. 2012 Nov 22 - "The study group consisted of 1043 subjects, including 683 subjects with NFG and 360 subjects with IFG (100≤fasting glucose <126mg/dL) ... Arterial stiffness was higher in the IFG group than in subjects with NFG even after adjustment for all confounding variables including hs-CRP and oxidative stress markers. In addition, fasting glucose and insulin were positively and independently associated with the ba-PWV in non-diabetic healthy adults"
Health Focus (Surgery):
News & Research:
QualityCounts.com Anti-aging Newsletter
Netvibes basic (free)