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Recent Longevity News for the week ending 7/6/22

Light during sleep in older adults linked to obesity, diabetes, high blood pressure - Science Daily, 6/27/22 - "In a sample of older men and women ages 63 to 84, those who were exposed to any amount of light while sleeping at night were significantly more likely to be obese, and have high blood pressure and diabetes compared to adults who were not exposed to any light during the night"


Abstracts from this week:

Quercetin ameliorated cardiac injury via reducing inflammatory actions and the glycerophospholipid metabolism dysregulation in a diabetic cardiomyopathy mouse model - Food Funct 2022 Jun 30 - "Quercetin has multiple protective effects against cardiometabolic diseases, but the biological mechanisms underlying the benefits in diabetic cardiomyopathy (DCM) are unclear ... Such findings showed that quercetin may ameliorate cardiac dysfunction and myocardial fibrosis via reducing inflammatory actions and the glycerophospholipid metabolism dysregulation in DCM" - See quercetin at Amazon.com.


Serum L-Carnitine Levels Are Associated With First Stroke in Chinese Adults With Hypertension - Stroke 2022 Jun 30 - "The mean level of serum L-carnitine in the stroke population was 4.7 μg/mL, which was significantly lower than that of the control group (5.7 μg/mL). When L-carnitine was assessed as quintiles, compared with the reference group (quintile 1, <3.3 μg/mL), the odds of stroke were 0.62 (95% CI, 0.39-1.00) in quintile 2, 0.66 (95% CI, 0.40-1.10) in quintile 3, 0.47 (95% CI, 0.28-0.81) in quintile 4, and 0.50 (95% CI, 0.30-0.84) in quintile 5. The trend test was significant (P=0.01). When quintiles 2 to 5 were combined, the adjusted odds ratio of first stroke was 0.58 (95% CI, 0.38-0.87) compared with quintile 1" - See l-carnitine at Amazon.com.


Threonine supplementation prevents the development of fat deposition in mice fed a high-fat diet - Food Funct 2022 Jun 29 - "Obesity is the main factor involved in the onset of many diseases. Threonine supplementation has been demonstrated to reduce fat mass and serum triglycerides in already obese mice ... These results suggest that long-term threonine supplementation inhibited fat mass and improved lipid metabolism, making it a potential agent to prevent the development of diet-induced obesity" - See threonine at Amazon.com.

  • Theanine vs Threonine: What You Need To Know - supplementyoursleep.com - "Like theanine, threonine is an amino acid, one you’ve probably eaten today — it exists in high quantities in some meat, eggs, dairy, and leafy greens. Threonine is necessary for the formation of healthy muscle tissue, as well as nervous system and liver function, throughout the body. In contrast, theanine is a non-dietary/non-essential amino acid; there won’t be negative consequences if you don’t get enough of it in your diet ... However, we don’t see threonine (normally l-threonine) as a supplement as commonly because most people get enough of it in their diets. This may not be true for everyone — including some vegans/vegetarians — but it’s simply not that common of a sleep supplement ingredient, at least from what I’ve seen ... Though perhaps less common than theanine supplementation, threonine supplements and medicines DO exist; they’re often used in the treatment of some digestion issues, as well as for anxiety and depression. If you think you may have a medical condition or are experiencing depression, your best bet is to reach out to a healthcare practitioner; sleep supplements are great for aiding and enhancing rest, but they won’t cure anxiety, depression, or other ailments with a few quick pills."

Angiotensin Receptor Blockers Are Associated With a Lower Risk of Progression From Mild Cognitive Impairment to Dementia - Hypertension 2022 Jun 29 - "Previous studies found that antihypertensive medications (AHMs) acting on the renin-angiotensin system had the potential to reduce the progression from mild cognitive impairment to dementia ... In patients with hypertension and mild cognitive impairment, angiotensin receptor blockers were associated with a lower risk of progression to dementia compared with ACE inhibitors and other classes of AHMs"

Genistein lowers fertility with pronounced effect in males: Meta-analyses on pre-clinical studies - Andrologia 2022 Jun 27 - "Genistein, an isoflavonoid, is found in a plethora of plant-based foods, and has been approved for use in various therapies. A couple of studies in adult men observed a negative correlation between genistein exposure and reproductive parameters ... Pooled analysis showed significant decreases in sperm count in males exposed to genistein during adulthood (Hedges's g = -2.51, p = 0.013) and in utero (Hedges's g = -0.861, p = 0.016) compared with controls. In males exposed to genistein in utero, serum testosterone levels decreased (Hedges's g = -6.301, p = 0.000) and luteinizing hormone (LH) (Hedges's g = 7.127, p = 0.000) and FSH (Hedges's g = 6.19, p = 0.000) levels increased in comparison with controls. In females, the number of corpora lutea (Hedges's g = -2.103, p = 0.019) and the litter size (Hedges's g = -1.773, p-value = 0.000) decreased; however, female reproductive hormones remained unaffected. These meta-analyses show that genistein has detrimental effects on male reproductive system and on the progression and sustenance of pregnancy, with more pronounced adverse impact in males, particularly when exposed in utero"

Omega-3 fatty acids, subclinical atherosclerosis, and cardiovascular events: Implications for primary prevention - Atherosclerosis 2022 Jun 20 - "coronary artery calcium (CAC) ... In an ethnically diverse population free of clinical CVD, higher plasma omega-3 fatty acid levels were associated with fewer long-term CVD events. The absolute decrease in CVD events with higher omega-3 fatty acid levels was more apparent at higher CAC scores" - See omega-3 supplements at Amazon.com.

Omega-3 fatty acids and metabolic partitioning of fatty acids within the liver in the context of nonalcoholic fatty liver disease - Curr Opin Clin Nutr Metab Care 2022 Jul 1 - "Nonalcoholic fatty liver disease (NAFLD) is now the most prevalent form of liver disease globally, affecting about 25% of the world's adult population. It is more common in those living with obesity, where it may affect as many as 80% of individuals ... triacylglycerols (TAGs) ... Increased intake of EPA and DHA may reduce the likelihood of hepatic TAG accumulation and could be used to reduce liver fat in patients with NAFLD" - See omega-3 supplements at Amazon.com.

Thyroid stimulating hormone levels are associated with genetically predicted nonalcoholic fatty liver disease - J Clin Endocrinol Metab 2022 Jun 28 - "Multivariable logistic regression model suggested a "dose-response" relationship between TSH (Q4 vs. Q1: OR = 1.29, 95% CI = 1.10 - 1.52; Ptrend = 0.001) and NAFLD. BMI and ALT partially mediated the association between TSH and NAFLD, while the proportion of the mediation effects of BMI and ALT were 39.1% and 22.3%, respectively. In MR analyses, the inverse-variance weighted method was selected as primary method and suggested a putative causal effect of NAFLD on serum TSH levels"

Empagliflozin for Heart Failure With Preserved Left Ventricular Ejection Fraction With and Without Diabetes - Circulation 2022 Jun 28 - "In patients with heart failure and a preserved ejection fraction enrolled in EMPEROR-Preserved (Empagliflozin Outcome Trial in Patients With Chronic Heart Failure With Preserved Ejection Fraction), empagliflozin significantly reduced the risk of heart failure outcomes irrespective of diabetes status at baseline" - See empagliflozin inhousepharmacy.vu.





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