|
|
|
Home >
Anti-aging Research > Hesperidin
Hesperidin
Related Topics:
Specific Recommendations:
News & Research:
-
Citrus extracts show energy burning potential, without side effects: Study
- Nutra USA, 5/17/11 - "consumption of 100 mg
hesperidin, 50 mg p-synephrine (from bitter orange), and 600 mg naringin
increased the resting metabolic rate by about 18 percent ... If one assumes
that the product was taken twice a day for one year, the theoretical
increase in calorie consumption would amount to over 31 pounds ... None of
the treatment groups exhibited changes in heart rate or blood pressure
relative to the control group, nor there were no differences in
self-reported ratings of 10 symptoms between the treatment groups and the
control group ... the thermogenic effect of p-synephrine may be increased by
naringin and hesperidin via an enhancement in the production of the
expression of adiponectin, a hormone released from fat cells, which plays an
important role in the regulation of insulin sensitivity and energy" -
[Abstract]
-
Orange juice flavanone may benefit heart health: Study - Nutra USA,
12/17/10 - "The researchers reported that blood
pressure was significantly lowered after 4 weeks consumption of orange juice
or a hesperidin rich drink when compared to a placebo drink" - [Abstract]
-
Daily Glass of Orange Juice Is Heart Smart - WebMD, 7/20/09 -
"An antioxidant in orange juice called hesperidin
improves blood vessel function and helps lower a person’s risk of heart
disease ... An antioxidant in orange juice called hesperidin improves blood
vessel function and helps lower a person’s risk of heart disease"
-
Citrus flavanones show neuroprotection potential - Nutra USA, 1/21/08 -
"These results first demonstrate that the citrus
flavanones hesperidin, hesperetin, and neohesperidin, even at physiological
concentrations, have neuroprotective effects against H2O2-induced
cytotoxicity in PC12 cells ... These dietary antioxidants are potential
candidates for use in the intervention for neurodegenerative diseases ...
One such disease that is mentioned Alzheimer's disease" - [Abstract]
-
Citrus extracts get cholesterol-lowering boost - Nutra USA, 3/26/07
-
Men's Fitness: Boost your good cholesterol sky-high: want to live longer?
Try raising this cholesterol with our 10 strategies - findarticles.com,
2/02 - "In a Canadian study, drinking a few glasses
of orange juice every day for four weeks increased participants' HDL by 21
percent, possibly due to a flavonoid called hesperidin that appears
extremely HDL-friendly"
-
High Levels of HDL Cholesterol Can Save Your Life - ABC News, 11/3/00 -
"So how much HDL is enough? Current guidelines say
35 milligrams per deciliter of blood (mg/dl) is normal, but most
cardiologists would prefer you to have an HDL count that’s twice that. “The
higher the better,” says Gaziano. “Once you get over 60 mg/dl, it’s a strong
positive factor in avoiding heart disease.” ... this will increase your HDL
by 21 percent (or 10 to 20 points) within 4 weeks. “We’re not sure, but this
effect may be due to a flavonoid in orange juice called hesperidin"
-
Herbal Treatment for Varicose Veins - Nutrition Science News, 7/00
Abstracts:
-
Rutin and Hesperidin
Alleviate Paclitaxel-Induced Nephrocardiotoxicity in Wistar Rats via Suppressing
the Oxidative Stress and Enhancing the Antioxidant Defense Mechanisms - Evid
Based Complement Alternat Med 2023 Feb 22 - "Paclitaxel
is a primary chemotherapy agent that displays antitumor activity against a
variety of solid tumors. However, the clinical effectiveness of the drug is
hampered by its nephrotoxic and cardiotoxic side effects ... In
paclitaxel-treated rats, the treatment of rutin and hesperidin decreased the
elevated serum levels of creatinine, urea, and uric acid, indicating a recovery
of kidney functions. The cardiac dysfunction in paclitaxel-treated rats that got
rutin and hesperidin treatment also diminished, as shown by a substantial
reduction in elevated CK-MB and LDH activity ... Thus, paclitaxel likely induces
toxicity in the kidney and the heart by producing oxidative stress. The
treatments likely countered renal and cardiac dysfunction and histopathological
changes by suppressing oxidative stress and augmenting the antioxidant defenses.
Rutin and hesperidin combination was most efficacious in rescuing renal and
cardiac function as well as histological integrity in paclitaxel-administered
rats" - See rutin at Amazon.com and
hesperidin at Amazon.com.
-
Effect of Hesperidin
Supplementation on Liver Metabolomics and Gut Microbiota in a High-Fat
Diet-Induced NAFLD Mice Model - J Agric Food Chem 2022 Sep 1 -
"After 16 weeks of intervention, the mice in the HFD+HES
group showed a lower final body weight and liver weight and improved serum lipid
profiles when compared with the HFD group. Alleviation of liver dysfunction
induced by HFD was observed in HES-fed mice, and the expression of genes
involved in lipid metabolism was also altered. Moreover, HES changed the
composition of the intestinal microbiota and enriched specific genera such as
Bacteroidota. Liver metabolomics analysis indicated that HES enhanced the
abundance of metabolites in arginine-related as well as mitochondrial
oxidation-related pathways, and these metabolites were predicted to be
positively correlated with the gut genera enriched by HES. Together, these
results indicate that HFD-fed mice supplemented with HES showed a markedly
regulated hepatic metabolism concurrent with shifts in specific gut bacteria"
-
Investigation of the effect
of hesperidin on some reproductive parameters in testicular toxicity induced by
Bisphenol A - Andrologia 2022 Aug 19 - "Bisphenol A
(BPA) is one of the chemicals that cause dysfunction and infertility in
testicles. Therefore, it is crucial to develop effective treatments against this
damage. In this study, the effects of Hesperidin (HESP), a flavonoid in
testicular toxicity induced by BPA in rats, on oxidative stress, inflammation,
apoptosis, histological damage, spermatogenesis, steroidogenic enzymes and
reproductive hormones were investigated ... Bisphenol A (BPA) is one of the
chemicals that cause dysfunction and infertility in testicles. Therefore, it is
crucial to develop effective treatments against this damage. In this study, the
effects of Hesperidin (HESP), a flavonoid in testicular toxicity induced by BPA
in rats, on oxidative stress, inflammation, apoptosis, histological damage,
spermatogenesis, steroidogenic enzymes and reproductive hormones were
investigated"
-
Hesperetin, a Promising
Treatment Option for Diabetes and Related Complications: A Literature Review
- J Agric Food Chem 2022 Jul 8 - "The morbidity and
mortality of diabetes have increased dramatically in recent decades. Novel
strategies for treating diabetes and its complications with minimal side effects
are in urgent need. New monomeric molecules extracted from herbal medicine,
which is a form of alternative medicine, are being sought as drug candidates for
the treatment of diabetes and its complications. Hesperetin (Hst), a citrus
flavonoid, is of increasing interest in scientific studies recently due to its
properties in combating diabetes and its complications, whereas existing studies
are scattered and unsystematic"
-
Neuroprotective Effects of
Hesperidin and Naringin in SK-N-AS Cell as an In Vitro Model for Alzheimer's
Disease - J Am Nutr Assoc 2022 Jul 1 - "Hesperidin
and naringin are flavonoids that are found in citrus fruits. Our aim was to
create an in vitro model of Alzheimer's disease (AD) and to evaluate the
neuroprotective effects of hesperidin and naringin in SK-N-AS and AD model cells
... Hesperidin and naringin can be potentially used as neuroprotective agents.
Naringin may be more effective than hesperidin in the accumulation of β-amyloid
and tau proteins" - See hesperidin at Amazon.com
and naringin at Amazon.com.
-
Hesperidin protects against
cisplatin-induced cardiotoxicity in mice by regulating the p62-Keap1-Nrf2
pathway - Food Funct 2022 Mar 24 - "Hesperidin (HES)
is an abundant and economical dietary bioflavonoid, and it has several
pharmacological properties such as antioxidant activity and powerful cardiac
protection ... HES treatment reduced CP-induced cardiac pathologic damage and
leakage of the myocardial markers cardiac troponin I (cTnI), creatine kinase
(CK), and lactate dehydrogenase (LDH). HES treatment reduced levels of reactive
oxygen species (ROS) and malondialdehyde (MDA), which is an oxidative product,
and increased antioxidant marker levels including superoxide dismutase (SOD),
catalase (CAT), and glutathione (GSH). HES also reduced the CP-induced release
of the inflammatory factors tumour necrosis factor (TNF)-α and interleukin
(IL)-6 ... These findings suggest that HES may be a promising protective agent
against CP cardiotoxicity in future anticancer clinical practice"
-
Hesperidin suppresses
ERS-induced inflammation in the pathogenesis of non-alcoholic fatty liver
disease - Aging (Albany NY) 2022 Feb 10 - "HSP
significantly decreased the weight gain, hepatic steatosis but not serum lipid
profile and suppressed the serum levels of inflammatory factors in HFD-fed rats.
It was revealed by bioinformatics analysis that the inflammatory response and
IRE1α activation were enriched signaling pathways in NAFLD. The expression of
ERS-related biomarkers, GRP94, ATF6, ATF4, p-PERK and p- IRE1α, was
significantly suppressed by HSP in vivo and in vitro. Moreover, the inflammatory
markers, including IL-1β, IL-6, and TNF-α, were also decreased by HSP in vivo
and in vitro. Immunofluorescence staining exposed that the expression of GRP94
and p-PERK was decreased by HSP in vitro"
-
Effect of the consumption of
hesperidin in orange juice on the transcriptomic profile of subjects with
elevated blood pressure and stage 1 hypertension: A randomized controlled trial
(CITRUS study) - Clin Nutr 2021 Dec;40(12) -
"Hesperidin exerts cardiovascular beneficial effects, but its mechanisms of
action remain undefined. In a previous study we demonstrated that a single dose
and a 12-week treatment of hesperidin decreased systolic blood pressure ... OJ
(containing 345 mg of hesperidin; n = 15) or EOJ (containing 600 mg of
hesperidin; n = 11) ... A single dose consumption of EOJ could protect from
insulin resistance. Moreover, EOJ decrease the expression of proinflammatory
genes after 12-week treatment providing a possible mechanism of action on
inflammation pathway"
-
Hesperidin Inhibits
UVB-Induced VEGF Production and Angiogenesis via the Inhibition of PI3K/Akt
Pathway in HR-1 Hairless Mice - Biol Pharm Bull 2021;44(10):1492-1498 -
"Hesperidin is a citrus flavanone glycoside with potent
anti-inflammatory effects that interferes with UVB-stimulated angiogenesis in
skin ... We found hesperidin treatment inhibited skin neovascularization skin
induced by repetitive UVB light exposure. Exposure to UVB radiation induces the
expression of vascular endothelial growth factor (VEGF), matrix
metalloproteinase-13 (MMP-13), and MMP-9, but we found all of these were
inhibited by treatment with hesperidin ... Because it affects the mediators of
angiogenesis, our data suggest hesperidin has an anti-angiogenic effect on the
pathologic skin neovascularization induced by UVB light. Thus, hesperidin may
prove useful in the treatment of skin injuries caused by UVB light exposure"
-
8 weeks of 2S-Hesperidin supplementation improves muscle mass and reduces fat in
amateur competitive cyclists: randomized controlled trial - Food & Function,
Apr 21 - "A double-blind, parallel and randomized trial,
was carried out with 40 amateur cyclists that were divided in two groups, one
taking 2S-hesperidin (500 mg d−1, n = 20) and another taking placebo (500 mg d−1
microcellulose, n = 20) for 8 weeks. Dual-energy X-ray absorptiometry (DXA) and
anthropometric measurements were used to assess the effect of both treatments on
body composition. In addition, the resting metabolic rate was measured. In
comparison to placebo, DXA analysis showed a decrease in percentage body fat
(%BF) (−10.4%; p = 0.035) and lower limb fat mass (−10.5%; p = 0.029) in favour
of 2S-hesperidin. After evaluation of anthropometric data, a decrease in %BF
(−3.7%; p = 0.006), total body fat (−3.0%; p = 0.047), ∑ of 8 skinfolds (−6.1%;
p = 0.008) was observed in 2S-hesperidin group, but not in placebo.
Additionally, there was an increase in muscle mass percentage (1.0%; p = <0.001)
and total muscle mass (1.7%; p = 0.011) after ingestion of 2S-hesperidin, with
no changes in placebo. Chronic intake of 2S-hesperidin decreased fat mass in
amateur cyclists, evaluated through different body composition measurement
methodologies (DXA and anthropometry). In addition, 2S-hesperidin
supplementation showed a promoting effect on muscle development" - [Nutra
USA]
-
Effect of Hesperidin against
Induced Colon Cancer in Rats: Impact of Smad4 and Activin A Signaling Pathway
- Nutr Cancer 2021 Apr 5 - "This study demonstrated the
chemopreventive effect of Hsd against CRC by modulating Smad4 and activin A
signaling in vivo. Further studies are needed to demonstrate its clinical value
and explore its possible role in advanced malignancy"
-
Glucosyl Hesperidin Has an
Anti-diabetic Effect in High-Fat Diet-Induced Obese Mice - Biol Pharm Bull
2021;44(3):422-430 - "Glucosyl hesperidin (GH) is a
water-soluble derivative of hesperidin, a citrus flavonoid. GH has various
pharmacological effects, such as hypolipidemic and hypouricemic effects, and may
therefore be a useful supplement or drug. In the present study, we evaluated the
effects of long- and short-term intake of GH on hyperglycemia and macrophage
infiltration into the adipose tissue of high-fat diet (HFD)-fed mice. Long-term
(11-week) consumption of GH tended to reduce body weight and the fasting blood
glucose concentration of the HFD-fed mice, and ameliorated glucose intolerance
and insulin resistance, according to glucose and insulin tolerance tests.
Additionally, although GH did not affect fat pad weight, it reduced HFD-induced
macrophage infiltration into adipose tissue. Short-term (2-week) consumption of
GH did not affect the HFD-induced increases in body weight or fasting blood
glucose, and it did not ameliorate glucose intolerance or insulin resistance.
However, short-term intake did reduce the HFD-induced macrophage infiltration
and monocyte chemotactic protein 1 (MCP-1) expression in adipose tissue.
Furthermore, hesperetin, which is an aglycone of GH, inhibited MCP-1 expression
in 3T3-L1 adipocytes, 3T3-L1 adipocytes co-cultured with RAW264 macrophages, and
tumor necrosis factor-α-treated 3T3-L1 adipocytes. The present findings suggest
that daily consumption of GH may have preventive and/or therapeutic effects on
obesity-related diseases, such as diabetes mellitus"
-
Effects of 8 Weeks of
2S-Hesperidin Supplementation on Performance in Amateur Cyclists - Nutrients
2020, 12(12) - "2S-Hesperidin is a flavanone (flavonoid)
found in high concentrations in citrus fruits. It has an antioxidant and
anti-inflammatory effects, improving performance in animals ... A double-blind,
randomized, placebo-controlled trial was carried out between late September and
December 2018. Forty amateur cyclists were randomized into two groups: one
taking 500 mg/day 2S-hesperidin and the other taking 500 mg/day placebo (microcellulose)
for eight weeks ... Supplementation with an orange extract (2S-hesperdin) 500
mg/day improves estimated FTP and maximum power performance in amateur cyclists"
- [Nutra
USA]
-
Influence of Hesperidin
on Systemic Immunity of Rats Following an Intensive Training and Exhausting
Exercise Nutrients. 2020 May 1 - "Intensive training
and exhausting exercise can disrupt innate and acquired immunity. The flavanone
hesperidin has shown immunomodulatory properties in physiological and some
pathological conditions, and positive effects on exercise-induced oxidative
stress ... female Wistar rats were randomized into an intensive training group
or a sedentary group. Intensive training was induced by running in a treadmill 5
days per week (including two exhausting tests) for five weeks. Throughout the
training period, 200 mg/kg of hesperidin or vehicle was administered by oral
gavage three times per week. At the end, blood, thymus, spleen and macrophages
were collected before, immediately after and 24 h after an additional final
exhaustion test. Hesperidin supplementation enhanced natural killer cell
cytotoxicity and the proportion of phagocytic monocytes, attenuated the
secretion of cytokines by stimulated macrophages, prevented the leukocytosis
induced by exhaustion and increased the proportion of T helper cells in the
thymus, blood and spleen. These results suggest that hesperidin can prevent
exhausting exercise-induced immune alterations" - See
hesperidin at Amazon.com and
hesperidin at iHerb.
-
Acute Effects of Hesperidin
in Oxidant/Antioxidant State Markers and Performance in Amateur Cyclists -
Nutrients 2019, 11(8), 1898 - "significant differences
in average power (+2.27%, p = 0.023), maximum speed (+3.23%, p = 0.043) and
total energy (∑ 4 sprint test) (+2.64%, p = 0.028) between Cardiose® and placebo
were found in the best data of the repeated sprint test ... Our findings showed
improvements in anaerobic performance after Cardiose® intake, but not in
placebo, suggesting the potential benefits of using Cardiose® in sports with a
high anaerobic component" - [Nutra
USA]
-
Benefits of Hesperidin
for Cutaneous Functions - Evid Based Complement Alternat Med. 2019 Apr
2;2019:2676307 - "Hesperidin is a bioflavonoid, with high concentration in
citrus fruits. In addition to its well-known benefits for cardiovascular
function, type II diabetes, and anti-inflammation, recent studies have
demonstrated multiple benefits of hesperidin for cutaneous functions, including
wound healing, UV protection, anti-inflammation, antimicrobial, antiskin cancer,
and skin lightening. In addition, hesperidin enhances epidermal permeability
barrier homeostasis in both normal young and aged skin. The mechanisms by which
hesperidin benefits cutaneous functions are attributable to its antioxidant
properties, inhibition of MAPK-dependent signaling pathways, and stimulation of
epidermal proliferation, differentiation, and lipid production. Because of its
low cost, wide availability, and superior safety, hesperidin could prove useful
for the management of a variety of cutaneous conditions"
-
Hesperidin Protects
Against Intestinal Inflammation By Restoring Intestinal Barrier Function and Up
Regulating Treg Cells - Mol Nutr Food Res. 2019 Feb 28 -
"Hesperidin
supplementation ameliorated DSS-induced colitis. Specifically, hesperidin
ameliorates intestine inflammation through decreasing MDA activity and enhancing
SOD and GSH activities. Hesperidin also obviously upregulation Nrf2 antioxidant
pathway and increased the protein expression of HO-1 and NQO1. Additionally,
hesperidin significantly reduced the levels of inflammatory factors and
increased the levels of anti-inflammatory factors in the colon tissues. Further
analysis showed that hesperidin could improve the expression of tight junction
proteins and intestinal permeability, as well as increased the Treg population.
In Caco-2 cells, we showed that hesperidin prevented TNF-α/IFN-γ-induced reduced
in TEER and morphological disruption. Moreover, hesperidin also was shows
decreased the epithelial permeability and suppress proinflammatory responses"
-
The citrus flavanone
hesperetin preferentially inhibits slow-inactivating currents of an LQT3
syndrome Na+ channel mutation - Br J Pharmacol. 2019 Jan 16 -
"lethal
ventricular arrhythmias in the Long QT syndrome subtype 3 (LQT3) ... HSP
preferentially inhibits the slow inactivation phase of INa , more markedly in
the mutant R1623Q. HSP could be used as a template to develop drugs against
lethal cardiac arrhythmias in LQT3"
-
Hesperidin Prevents
Nitric Oxide Deficiency-Induced Cardiovascular Remodeling in Rats via
Suppressing TGF-β1 and MMPs Protein Expression - Nutrients. 2018 Oct
19;10(10) - "n-nitro l-arginine methyl ester (l-NAME) ... Male Sprague-Dawley
rats were treated with l-NAME (40 mg/kg), l-NAME plus hesperidin (15 mg/kg),
hesperidin (30 mg/kg), or captopril (2.5 mg/kg) for five weeks (n = 8/group).
Hesperidin or captopril significantly prevented the development of hypertension
in l-NAME rats. l-NAME-induced cardiac remodeling, i.e., increases in wall
thickness, cross-sectional area (CSA), and fibrosis in the left ventricular and
vascular remodeling, i.e., increases in wall thickness, CSA, vascular smooth
muscle cells, and collagen deposition in the aorta were attenuated by hesperidin
or captopril. These were associated with reduced oxidative stress markers, tumor
necrosis factor-alpha (TNF-α), transforming growth factor-beta 1 (TGF-β1), and
enhancing plasma nitric oxide metabolite (NOx) in l-NAME treated groups.
Furthermore, up-regulation of tumor necrosis factor receptor type 1 (TNF-R1) and
TGF- β1 protein expression and the overexpression of matrix metalloproteinase-2
(MMP-2) and matrix metalloproteinase-9 (MMP-9) was suppressed in l-NAME rats
treated with hesperidin or captopril. These data suggested that hesperidin had
cardioprotective effects in l-NAME hypertensive rats"
-
Long-term Treatment with
Hesperidin Improves Endothelium-dependent Vasodilation in Femoral Artery of
Spontaneously Hypertensive Rats: The Involvement of NO-synthase and Kv Channels
- Phytother Res. 2016 Jul 1 - "Hesperidin is the most
common flavonoid found in citrus fruits and is expected to exert vasodilation
action relevant to its health benefits ... The results of our experiment
indicate that hesperidin might improve the endothelium-dependent vasodilation
during hypertension, possibly through the enhancement of Kv channels function"
- See
hesperidin at Amazon.com
 .
-
Hesperidin
ameliorates cognitive dysfunction, oxidative stress and apoptosis against
aluminium chloride induced rat model of Alzheimer's disease - Nutr
Neurosci. 2016 Feb 15 - "In our lab, we have
previously reported that hesperidin, a citrus bioflavonoid reversed
memory loss caused by aluminium intoxication through attenuating
acetylcholine esterase activity and the expression of Amyloid β
biosynthesis related markers ... Results of the present study
demonstrated that hesperidin could be a potential therapeutic agent in
the treatment of oxidative stress and apoptosis associated
neurodegenerative diseases including AD"
-
Effect of Hesperidin with and without a Calcium (Calcilock®) Supplement
on Bone Health in Postmenopausal Women - J Clin Endocrinol Metab.
2016 Jan 11 - "Citrus fruits contain unique
flavanones. One of the most abundant of the flavanones, hesperidin, has
been shown to prevent bone loss in ovariectomized rats ... Calcium plus
hesperidin, but not hesperidin alone, improved bone calcium retention by
5.5%"
-
Hesperidin Supplementation Modulates Inflammatory Responses Following
Myocardial Infarction - J Am Coll Nutr. 2015 Mar 11:1-7 -
"Hesperidin supplementation could compensate for
decreased levels of adiponectin and HDL-C and increased levels of E-selectin in
patients with myocardial infarction. These results support the concept that
certain flavonoids in the diet can be associated with significant health
benefits, including heart health"
-
Hesperidin
ameliorates behavioural impairments and neuropathology of transgenic APP/PS1
mice - Behav Brain Res. 2014 Dec 12 - "Our findings
suggest that hesperidin might be a potential candidate for the treatment of AD
or even other neurodegenerative diseases"
-
Hesperidin
protects testicular and spermatological damages induced by cisplatin in rats
- Andrologia. 2014 Sep 13 - "this study clearly
demonstrated that hesperidin has protective effects on cisplatin-induced
reproductive system toxicity depending on its antioxidant properties. Thus, it
is thought that hesperidin may be useful against cisplatin toxicity in patients
with cancer in terms of reproductive system"
-
Hesperidin
and naringin attenuate hyperglycemia-mediated oxidative stress and
proinflammatory cytokine production in high fat fed/streptozotocin-induced type
2 diabetic rats - J Diabetes Complications. 2012 Jul 16 -
"Diabetes was induced by feeding rats with an HFD for
2weeks followed by an intraperitoneal injection of STZ (35mg/kg body weight). An
oral dose of 50mg/kg hesperidin or naringin was daily given for 4weeks after
diabetes induction ... At the end of the experimental period, blood was obtained
from jugular vein and livers were rapidly excised and homogenized for
biochemical assays. In the diabetic control group, levels of glucose,
glycosylated hemoglobin (HbA1c%), MDA, NO, TNF-α and IL-6 were significantly
increased, while serum insulin, GSH, vitamin C, and vitamin E levels were
decreased. Both hesperidin and naringin administration significantly reversed
these alterations. Moreover, supplementation with either compound significantly
ameliorated serum and liver MDA, NO and glutathione, and liver antioxidant
enzymes"
-
Citrus
Polyphenol Hesperidin Stimulates Production of Nitric Oxide in Endothelial Cells
while Improving Endothelial Function and Reducing Inflammatory Markers in
Patients with Metabolic Syndrome - J Clin Endocrinol Metab. 2011 Feb 23 -
"Hesperidin, a citrus flavonoid, and its metabolite
hesperetin may have vascular actions relevant to their health benefits ...
Treatment of BAEC with hesperetin acutely stimulated phosphorylation of Src,
Akt, AMP kinase, and endothelial NO synthase to produce NO; this required
generation of H(2)O(2). Increased adhesion of monocytes to BAEC and expression
of vascular cell adhesion molecule-1 in response to TNF-α treatment was reduced
by pretreatment with hesperetin. In the clinical study, when compared with
placebo, hesperidin treatment increased flow-mediated dilation (10.26 +/- 1.19
vs. 7.78 +/- 0.76%; P = 0.02) and reduced concentrations of circulating
inflammatory biomarkers (high-sensitivity C-reactive protein, serum amyloid A
protein, soluble E-selectin). Conclusions: Novel mechanisms for hesperetin
action in endothelial cells inform effects of oral hesperidin treatment to
improve endothelial dysfunction and reduce circulating markers of inflammation
in our exploratory clinical trial. Hesperetin has vasculoprotective actions that
may explain beneficial cardiovascular effects of citrus consumption"
-
Hesperidin contributes to the vascular protective effects of orange juice: a
randomized crossover study in healthy volunteers - Am J Clin Nutr. 2010
Nov 10 - "Throughout the three 4-wk periods,
volunteers consumed daily 500 mL orange juice, 500 mL control drink plus
hesperidin (CDH), or 500 mL control drink plus placebo (CDP) ... Diastolic
blood pressure (DBP) was significantly lower after 4 wk consumption of
orange juice or CDH than after consumption of CDP (P = 0.02), whereas
microvascular endothelium-related reactivity was not significantly affected
when measured after an overnight fast. However, both orange juice and CDH
ingestion significantly improved postprandial microvascular endothelial
reactivity compared with CDP (P < 0.05) when measured at the peak of plasma
hesperetin concentration"
-
Neuroprotective Effects of the Citrus Flavanones against H2O2-Induced
Cytotoxicity in PC12 Cells - J Agric Food Chem. 2008 Jan 12 -
"the citrus flavanones hesperidin, hesperetin, and
neohesperidin, even at physiological concentrations, have neuroprotective
effects against H 2O 2-induced cytotoxicity in PC12 cells. These dietary
antioxidants are potential candidates for use in the intervention for
neurodegenerative diseases" - See
hesperidin at Amazon.com.
-
Hesperidin, a Citrus Flavonoid, Inhibits Bone Loss and Decreases Serum and
Hepatic Lipids in Ovariectomized Mice - J. Nutr. 133:1892-1897, June
2003 -
"These results suggest a possible role for citrus
flavonoids in the prevention of lifestyle-related diseases because of their
beneficial effects on bone and lipids"
-
Biological effects of hesperidin, a Citrus flavonoid. (note II):
hypolipidemic activity on experimental hypercholesterolemia in rat
- Farmaco. 1995 Sep;50(9):595-9 - "Hesperidin, the
most important flavanone of Citrus sp., significantly increases HDL"
|
|
