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Recent Longevity News for the week ending 1/22/20

Routine Cannabis Screening in CVD Patients: Have We Hit a Tipping Point? - Medscape, 1/21/20 - "The authors call for "routine screening for marijuana use" and a "broad commitment" from government and researchers to pursue marijuana-related research to clarify the CV safety profile. They cite the increasing use and potency of marijuana and a spike in reported cannabis-related adverse health effects ... Observational studies have suggested an association between marijuana use and a broad range of CV risks, such as myocardial infarction (MI), arrhythmias, and cerebrovascular events ... When you actually look at the chemical toxin profile of the combustion products of marijuana compared with tobacco when both are smoked, it's actually quite comparable ... So we would anticipate that the cardiovascular and pulmonary effects may also be similar ... Concerns have also been raised about potential interactions with commonly used cardiovascular drugs and cannabinoids, including THC and CBD, which are metabolized by the cytochrome P450 enzymatic (CYP) pathway in the liver"

Human exposure to aluminum linked to familial Alzheimer's disease - Science Daily, 1/21/20 - "Researchers found significant amounts of aluminum content in brain tissue from donors with familial AD. The study also found a high degree of co-location with the amyloid-beta protein, which leads to early onset of the disease ... The results were striking. The aluminum content of the brain tissue from donors with the genetic mutation was universally high, with 42% of tissues having a level considered pathologically significant, and the levels were significantly higher than those in the control set ... Either way, the new research confirms my resolve that within the normal lifespan of humans, there would not be any AD if there were no aluminum in the brain tissue. No aluminum, no AD"

Chronic inflammation is long lasting, insidious, dangerous. And you may not even know you have it - Washington Post, 1/20/20 - "People typically don’t know that they have chronic inflammation until it’s too late ... Individuals often learn they have chronic inflammation when they develop an autoimmune disease, such as Crohn’s disease, lupus, or Type 1 diabetes, since inflammation is a hallmark of autoimmune disorders. But experts believe chronic inflammation also plays a role in developing heart disease, cancer, kidney disease, nonalcoholic fatty liver disease, neurodegenerative disorders, cognitive decline and mental health illnesses, such as depression, post-traumatic stress disorder and schizophrenia ... Numerous factors appear to raise the risk of chronic inflammation, among them social isolation, psychological stress, disturbed sleep, chronic infections, physical inactivity, poor diet, obesity and exposure to air pollutants, hazardous waste products, industrial chemicals and tobacco smoke ... Diet is one of the key factors that influences inflammation in the body,” Slavich says. “Whereas fried foods, red meat, sodas, and white bread and pastries that have refined carbohydrates tend to increase inflammation, fruits, nuts, green leafy vegetables, tomatoes and olive oil tend to reduce inflammation ... Scientists think chronic inflammation causes oxidative stress in the body, which is an imbalance between the production of dangerous free radicals, molecules that harm healthy tissue in the body, and antioxidants, substances that clean up waste products and neutralize them. This can damage DNA as well as proteins and fatty tissue, which in turn accelerates biological aging ... Chronic inflammation can contribute to cognitive decline and mental health disorders by boosting age-related immune system deterioration, known as immunosenescence, and by promoting vascular and brain aging, which, in combination, degrade neural and cognitive function ... Chronic inflammation can also cause threat sensitivity and hypervigilance, which gives rise to anxiety disorders and PTSD, as well as fatigue and social-behavioral withdrawal, which are key symptoms of depression ... The most widely used test measures levels of C-reactive protein (CRP) in the blood. CRP, a substance produced by the liver, rises when chronic inflammation is present, although the standard CRP test is nonspecific — that is, it indicates inflammation, but cannot pinpoint exactly where it is. A second, more sensitive test (hs-CRP) suggests a higher risk of heart attack, although it too can be imprecise"

If you want to protect yourself from the flu, you may want to try this natural remedy - 10News, 1/20/20 - "“No, you definitely want to have your flu shot, it’s just good to have as a backup,” Bradley said ... The doctor even takes it herself ... ”I have taken it and I have a bottle at home. And I recently had a friend who had influenza and the first thing I told her was, 'go to the doctor and take elderberry syrup,' ” she said" - Note:  It doesn't have any studies to back it up however, see elderberry syrup at Amazon.com and note all the 4.6 and 4.7 star ratings.

Coconut Oil Consumption Linked to Increased LDL - Medscape, 1/20/20 - "Consuming 3 to 4 tablespoons of coconut oil daily was associated with an estimated 10-mg/dL increase ― about a 9% jump ― in LDL levels"

Dozens of non-oncology drugs can kill cancer cells - Science Daily, 1/20/20 - "They found nearly 50 non-cancer drugs -- including those initially developed to lower cholesterol or reduce inflammation -- that killed some cancer cells while leaving others alone ... Some of the compounds killed cancer cells in unexpected ways. "Most existing cancer drugs work by blocking proteins, but we're finding that compounds can act through other mechanisms," said Corsello. Some of the four-dozen drugs he and his colleagues identified appear to act not by inhibiting a protein but by activating a protein or stabilizing a protein-protein interaction. For example, the team found that nearly a dozen non-oncology drugs killed cancer cells that express a protein called PDE3A by stabilizing the interaction between PDE3A and another protein called SLFN12 -- a previously unknown mechanism for some of these drugs ... For example, the anti-inflammatory drug tepoxalin, originally developed for use in people but approved for treating osteoarthritis in dogs, killed cancer cells by hitting an unknown target in cells that overexpress the protein MDR1, which commonly drives resistance to chemotherapy drugs ... For example, the alcohol dependence drug disulfiram (Antabuse) killed cell lines carrying mutations that cause depletion of metallothionein proteins. Compounds containing vanadium, originally developed to treat diabetes, killed cancer cells that expressed the sulfate transporter SLC26A2" - Reminds me of this from 18 years ago but we never heard anything further about it:

  • Dog's tale of survival opens door in cancer research - USA Today, 7/24/02 - "The treatment is a cocktail of so-called anti-angiogenic drugs, which have been widely researched for more than a decade and work by starving tumors of their blood supply. Researchers say the three-drug combination, which Haber mixed into Navy's regular dog food, targets the cancer from many angles ... When researchers heard that Navy was cancer-free after receiving a cocktail of drugs already approved by the Food and Drug Administration — Celebrex, tamoxifen (sold as Nolvadex) and doxycycline — the treatment became known as the Navy Protocol ... Navy's treatment, though experimental, cost $2,000"

Fish Oil Supplements Tied to Sperm Health - NYT, 1/17/20 - "Researchers studied 1,679 Danish men taking physical examinations for compulsory military service. Their average age was 19, and 98 of them reported taking fish oil supplements during the previous three months ... Compared with those who took none, men who took fish oil supplements for at least 60 days during the previous three months had higher sperm count, a greater proportion of normal sperm cells, higher average semen volume and larger average testicular size. They also had significantly lower follicle-stimulating hormone levels and lower luteinizing hormone levels, both indicators of better testicular function" - See omega-3 supplements at Amazon.com.

A doctor discovered how a vitamin could save a patient's life before their heart stopped beating - 10News, 1/17/20 - "(We were) running out of options, so my colleagues started giving vitamin B12 and the blood pressure magically started going up ... hen tissue isn't getting enough oxygen, it could be releasing this compound — hydrogen sulfide — and that's what the vitamin B12 binds to and says, 'nope,' and kind of takes it out of the circulation ... Freed says a vitamin B12 is now being used in a clinical trial by a fellow doctor to treat his sepsis patients"

Real risks associated with cannabis exposure during pregnancy - Science Daily, 1/17/20 - "maternal exposure to THC during pregnancy has a measurable impact on both the development of the organs of the fetus and the gene expression that is essential to placental function ... Real risks associated with cannabis exposure during pregnancy ... The researchers say both of those factors are likely contributing to the growth restriction that they observed in the offspring" - Note: I mentioned last week about how there sure seems to be a lot of wrong way drivers on the interstate in San Diego since they legalized pot. Additionally, I’m old but it seems like everyone else is losing their memory. I have to follow-up which seems like five times on everything from adding someone onto my membership at the gym, making an appointment with Scripps (plan on at least 10 calls to schedule an MRI), BathFitter installation, a loan, etc. You cannot make just one call or email and consider it taken care of anymore.  I dropped a prescription off at the pharmacy.  The pharmacist, who was about 30 years old, said it would be about 20 minutes so I had a seat.  About 5 minutes later, he saw me and asked if I was waiting for a prescription.  He forgot that he just talked to me five minutes prior and there were only two customers.  That kind of forgetfulness on their part is a side effect of pot.

Flu Shot No Match for 'B' Strain, Season Rages On - WebMD, 1/16/20 - "this season's vaccine is only a 58% match for the B strain of flu, known as B/Victoria, that is hitting children especially hard"

Drinking 1% rather than 2% milk accounts for 4.5 years of less aging in adults - Science Daily, 1/15/20 - "the more high-fat milk people drink, the shorter their telomeres are, according to the new BYU study, published in Oxidative Medicine and Cellular Longevity. The study revealed that for every 1% increase in milk fat consumed (drinking 2% vs. 1% milk), telomeres were 69 base pairs shorter in the adults studied, which translated into more than four years in additional biological aging. When Tucker analyzed the extremes of milk drinkers, adults who consumed whole milk had telomeres that were a striking 145 base pairs shorter than non-fat milk drinkers ... milk abstainers had shorter telomeres than adults who consumed low-fat milk" - Note:  But the question we should be asking is whether the people that drink the lower fat milk are just plain more health health conscience overall. Maybe the milk doesn't have anything to do with it.  It may be just one of the traits of people who watch their diet more.

San Diego flu cases up, but severity and deaths are down - CBS8, 1/13/20 - "See the video.  This doc sees Tamiflu the same as I do. You have to start Tamiflu as early as possible and it stops the flu in its tracks. The studies claim that the average flu is only 5 days and Tamiflu only cuts it down by a day. That doesn't sound accurate. When I get the flu, it's more like three weeks and Tamiflu cuts it down to three days and those three days aren't as severe. You can get the generic in Tijuana for about $16.  Also inhousepharmacy.vu.

Pot-Using Drivers Still Impaired When High Fades - WebMD, 1/14/20 - "Even when they're not high on marijuana, recreational users of the drug display signs of impaired driving ... Compared to nonusers, heavy marijuana users had worse driving performance during the test. For example, they hit more simulated pedestrians, went over the speed limit more often, made fewer stops at red lights, and crossed the center line more often ... The researchers also found that the start of marijuana use before age 16 was associated with worse performance on the driving simulator."

Chemicals in Tap Water Linked to Bladder Cancer - Medscape, 1/15/20 - "Exposure to chemicals found in drinking water after it has been disinfected with chlorine could be responsible for up to 1 in 20 cases of bladder cancer across the European Union. The number rises to as high as 1 in 5 in some countries" - See reverse osmosis systems at Amazon.com.

This is what I have.  It includes the alkaline and the UV.

Run a First Marathon, and Your Arteries May Look 4 Years Younger - NYT, 1/15/20 - "Ultimately, 136 men and women completed the race, in an average finishing time of 4.5 hours for the men and 5.5 hours for the women. A week or two later, they returned to the lab to repeat the tests ... Their aortas proved to be more flexible now. In fact, their arteries seemed to have shed the equivalent of about four years, in functional terms. The aorta of a 60-year-old marathoner in the study now expanded and contracted about as lithely as that of a 56-year-old participant did at the study’s start, and the 56-year-old’s arteries worked like those of a pre-race 52-year-old, and so on ... These improvements were most marked in older male runners and those whose finishing times had been slowest. They did not depend on changes in runners’ fitness or weight, which, in most cases, had been negligible. All that had mattered was that people had kept up with their training and raced."

Sobering Data on Alcohol-Related Deaths in the US - Medscape, 1/14/20 - "between 1999 and 2017, almost 1 million individuals died from some type of alcohol-related cause. In addition, the mention of alcohol in death certificates increased from nearly 36,000 per year to more than 72,000 during the same period ... This result is especially troubling because it comes "at a time of growing evidence that even one drink per day of alcohol can contribute to an increase in the risk of breast cancer for women" - Note:  Too often I hear the argument that pot is no worse than alcohol, as if alcohol wasn't a huge problem.  One in eight American adults is an alcoholic.  The logic seems to be the it's justification for increasing the problem.  Alcohol destroyed the lives of a lot of my family.

Prescription Fish Oil: 5 Things to Know - Medscape, 1/13/20 - "With its expanded indication, icosapent ethyl can now be used as an adjunct to statin therapy to reduce CV events in patients with elevated TG levels (≥150 mg/dL) and established atherosclerotic cardiovascular disease (ASCVD) or diabetes and at least two other CV risk factors. This recommendation is based on outcomes from REDUCE-IT, which demonstrated a 25% reduced risk of major CV events in patients receiving icosapent ethyl, and a 35% reduced risk reduction in participants with a history of ASCVD ... The available prescription fish oils are not true fish oil products, but rather are different formulations of omega-3 fatty acids derived from fish oil. Five prescription omega-3 PUFA are currently available in the United States, four of which are approved by the FDA to lower serum TG levels (Table), and one of which (Vascazen, Pivotal Therapeutics) is an FDA-regulated medical food for omega-3 deficiency in patients with CVD."

Could Your Morning Coffee Be a Weight-Loss Tool? - WebMD, 1/13/20 - "Those who drank 4 cups of caffeinated coffee per day over six months saw a nearly 4% drop in overall body fat"

Air pollution in childhood linked to schizophrenia - Science Daily, 1/7/20 - "the higher the level of air pollution, the higher the risk of schizophrenia. For each 10 ?g/m3 (concentration of air pollution per cubic metre) increase in the daily average, the risk of schizophrenia increases by approximately twenty per cent. Children who are exposed to an average daily level above 25 ?g/m3 have an approx. sixty per cent greater risk of developing schizophrenia compared to those who are exposed to less than 10 ?g/m3"

Air Pollution Exposure in Utero Tied to Childhood HbA1c Levels - Medscape, 1/11/20 - "air pollution causes a great deal of inflammation, and we know that other inflammatory exposures can affect organ development and function (such as brain, pancreas, liver, muscle and fat - all of which participate in blood sugar regulation) in ways that have long-lasting effects"

How to lower your resting heart rate - CNET, 1/19/20 - "Even if your resting heart rate isn't high enough to warrant a medical condition, it'll be better for you in the long run if it falls towards the lower end of the range. One comprehensive study of a cohort of men and women suggested a higher rate of mortality for people that had a resting heart rate of over 70 beats per minute"

BPA replacement, BPS, hinders heart function, study reveals - Science Daily, 1/9/20 - "BPA's counterpart replacement BPS can hinder heart function within minutes of a single exposure ... the study entailed treating mouse hearts with BPA and BPS at levels typically seen in people. Each chemical on its own was found to depress heart function by dampening heart contractions causing slower blood flow. However, BPS had a quicker impact -- within five minutes of exposure" - Sounds like they just replaced one bad substance with a less researched bad substance to fool the consumer.

Scientists Calculated How Much Longer You Can Live With a Healthy Lifestyle - Time, 1/8/20 - "adopting five healthy habits could extend life expectancy by 14 years for women and by 12 years for men: eating a diet high in plants and low in fats ... exercising at a moderate to vigorous level for several hours a week ... maintaining a healthy body weight ... not smoking ... consuming no more than one alcoholic drink a day for women and two for men"

Marijuana detected in homicide victims nearly doubles - Science Daily, 1/8/20 - "marijuana detected in homicide victims and found that the prevalence of marijuana almost doubled, increasing from 22 percent in 2004 to 42 percent in 2016" - Street people, accidents, heart conditions, depression, schizophrenia, homicide, lung problems, etc., all tied to pot and people think it's healthy.

I've suspected underreporting for a long time:

  • Driving Under the Influence of Marijuana and Illicit Drugs Among Persons Aged ≥ 16 Years — United States, 2018 - Medscape, 1/8/20 - "First, because NSDUH data are self-reported, they are subject to recall and social desirability biases. Second, variations in laws and regulations among states and counties regarding marijuana could have resulted in negative responses to the NSDUH substance use survey questions for fear of legal consequences, leading to an underestimation of the prevalence of the use and driving under the influence in some jurisdictions. Third, the NSDUH questions are not limited to driving under the influence of marijuana only or each illegal substance only; therefore, persons might be driving under the influence of more than one substance at a given time. Fourth, self-reported data are subject to the respondents' interpretations of being under the influence of a drug. Finally, NSDUH does not assess whether all respondents drive; therefore, reported percentages of impaired drivers might be underestimated."

Abstracts from this week:

Efficacy and Safety of Resveratrol in Type 1 Diabetes Patients: A Two-Month Preliminary Exploratory Trial - Nutrients. 2020 Jan 6;12(1) - "All patients received resveratrol in 500 mg capsules, twice daily for 60 days ... Resveratrol supplementation for 60 days significantly decreased FBS and HbA1c in comparison with the baseline values. Resveratrol treatment also resulted in a decrease in the level of a marker for oxidative stress, malondialdehyde, and an increase in total antioxidant capacity in T1D patients. Insulin, HOMA-IR, HOMA-β, and markers of liver and kidney function and inflammation were not significantly affected by resveratrol treatment. Overall, the results showed that 60 days of resveratrol supplementation exerted strong antidiabetic and antioxidant effects in patients with T1D" - See resveratrol products at Amazon.com.

Role of Resveratrol in Transmitochondrial AMD RPE Cells - Nutrients. 2020 Jan 6;12(1) - "treatment with different resveratrol formulations improved cell viability and decreased reactive oxygen species generation in each AMD patient cell line. Although further studies are required to establish the cytoprotective potential of resveratrol under different physiological conditions, this novel study established the positive effects of OTC resveratrol supplements in macular degeneration patient cybrid cell lines in vitro" - See resveratrol products at Amazon.com.

Theanine, the Main Amino Acid in Tea, Prevents Stress-Induced Brain Atrophy by Modifying Early Stress Responses - Nutrients. 2020 Jan 8;12(1) - "Npas4 and Lcn2 are involved in the brain atrophy and stress vulnerability of SAMP10 mice, which are prevented by the consumption of theanine, causing changes in the expression of these genes" - See theanine at Amazon.com.

Effect of Ten Weeks of Creatine Monohydrate Plus HMB Supplementation on Athletic Performance Tests in Elite Male Endurance Athletes - Nutrients. 2020 Jan 10;12(1) - "CrM plus HMB supplementation over 10 weeks showed a synergistic effect on aerobic power (measured as WAT, W4, and W8) during an incremental test but had no influence muscle mass" - See creatine at Amazon.com and HMB at Amazon.com.

Associations between Serum Levels of Cholesterol and Survival to Age 90 in Postmenopausal Women - J Am Geriatr Soc. 2020 Jan 13 - "HDL and LDL levels were not associated with survival to age 90 after adjustment for cardiovascular risk factors (HDL: quartile (Q) 2: odds ratio [OR] = 1.14 [95% confidence interval [CI] = .94-1.38]; Q3 OR = 1.08 [95% CI = .88-1.33]; Q4 OR = 1.09 [95% CI = .88-1.35]; LDL: Q2 OR = 1.07 [95% CI = .88-1.31]; Q3 OR = 1.27 [95% CI = 1.04-1.55]; Q4 OR = 1.07 [95% CI = .88-1.31]). Similarly, no associations were observed between HDL and LDL levels and survival to age 90 with mobility disability. High HDL was not associated with survival to age 90 with intact mobility after adjustment for other cardiovascular risk factors. Compared with the lowest LDL quartile, the three upper LDL quartiles were associated with greater odds of survival to age 90 with intact mobility (LDL: Q2 OR = 1.31 [95% CI = .99-1.74]; Q3 OR = 1.43 [95% CI = 1.07-1.92]; Q4 OR = 1.35 [95% CI = 1.01-1.80]; P = .05) ... Neither higher HDL nor lower LDL levels predicted survival to age 90, but higher LDL predicted healthy survival. These findings suggest the need for reevaluation of healthy LDL levels in older women"

Tolerability and efficacy of Sacubitril/ Valsartan in clinical practice - Intern Med J. 2020 Jan 6 - "Heart failure is a major cause of morbidity and mortality. Sacubitril/Valsartan has demonstrated reductions in HF hospitalisation, and all-cause mortality in patients with heart failure with reduced ejection fraction (HFrEF) ... 14% of patients were able to able to achieve maximal dose (97/103 mg twice daily) whilst 37% remained on 49/51 mg and 23% on 24/26 mg. The mean SBP reduced from 118 ± 18 mmHg to 109 ± 15 mmHg with symptomatic hypotension (30%) being the most common side effect leading to dose reduction or drug cessation. Left ventricular ejection fraction (LVEF) improved from 29.1 ± 9.7% to 33.8 ± 9.9% (p < 0.05) on drug. There was also a significant improvement in quality of life scores; EQ5D-VAS 40 pre vs 67 post Sacubitril/Valsartan (p < 0.05), and New York Heart Association class (p < 0.05). Importantly, ten patients lost an existing indication for device based therapy after treatment with Sacubitril/Valsartan ... Sacubitril/Valsartan is a much needed therapeutic advancement in the treatment of HF. Our study indicates it is well tolerated with improvements in cardiac function and symptoms. Sacubitril/Valsartan could redefine the definition of "optimal medical therapy' when assessing patients for device based therapies"

Effect of lycopene on testicular androgenic and anti-oxidative enzymes in cyproterone acetate-induced male infertile Wistar strain albino rats: An in vitro study - Andrologia. 2020 Jan 8:e13494 - "Incidents of male infertility are mushrooming worldwide. Oxidative stress plays a prime role for its onset. Considering this background, the study was designed to focus the direct role of lycopene on cyproterone acetate (CPA) induced testicular hypofunction in rat. Four groups have been considered including the vehicle-treated control, lycopene-treated control, CPA-treated and CPA+ lycopene-treated groups. Androgenic, antioxidant and toxicity profiles were assessed ... lycopene exposure to the testicular tissue of CPA-treated rat (CPA+ lycopene-treated) exhibited a significant (p < .05, p < .001) rectification in testicular catalase, superoxide dismutase, peroxidase, glutathione-S-transferase activities towards the vehicle- and lycopene-treated control groups. Toxicity profile also showed a significant (p < .001) recovery in CPA-treated group after direct exposure of lycopene towards the vehicle- and lycopene-treated control groups. So, it can be concluded that direct exposure of lycopene may rectify the CPA-induced testicular hypofunction either by its free radical-quenching ability or by stimulating antioxidant enzyme activity without modulating androgenic key enzyme directly" - See Jarrow Lyco-Sorb (contains Lyco-O-Mato) at Amazon.com.

Lycopene improves sperm quality: A promising nutrient for the treatment of male infertility - Phytother Res. 2020 Jan 10 - Doesn't show the write-up but I guess the title covers it.  See Jarrow Lyco-Sorb (contains Lyco-O-Mato) at Amazon.com.

Conjugated Linoleic Acid (CLA) and Alpha Linolenic Acid (ALA) Improve Cholesterol Homeostasis in Obesity by Modulating Distinct Hepatic Protein Pathways - Mol Nutr Food Res. 2020 Jan 9:e1900599 - "ALA-HFD significantly reduced liver weight, hepatic cholesterol levels and expression of the cholesterol synthesis enzyme farnesyl pyrophosphate synthase (FDPS) relative to HFD. ALA further increased expression of acetyl-coA oxidase (Acox1)-associated proteins and suppressed PPARα-induced proteins relative to HFD. CLA did not significantly attenuate hepatic lipid levels but was associated with reduced hepatic expression of fatty acid binding protein (FABP)-1/FABP4 levels relative to HFD, and reduced inflammatory pathway activation relative to ALA-HFD ... ALA and CLA exert distinct mechanistic advantages on cholesterol homeostasis and RCT in obesity" - See conjugated linoleic acid at Amazon.com and alpha lipoic acid at Amazon.com.

Ginsenoside Rg3 (Shenyi Capsule) Combined with Chemotherapy for Digestive System Cancer in China: A Meta-Analysis and Systematic Review - Evid Based Complement Alternat Med. 2019 Dec 17 - "Ginsenoside Rg3 combined with chemotherapy can improve the clinical efficacy and alleviate treatment-induced side effects for digestive system cancer" - See ginseng at Amazon.com.

The Association between Popular Diets and Serum Testosterone among Men in the United States - J Urol. 2020 Feb;203(2):398-404 - "Mean testosterone was lower among men with a low fat diet (410.8 ± 8.1 vs 443.5 ± 7.3, p=0.005) and a Mediterranean diet (412.9 ± 9.1 vs 443.5 ± 7.3, p=0.002). Multivariable analysis controlling for age, body mass index, activity level, diabetes, comorbidities and prostate cancer showed that men with a nonrestrictive diet had higher serum testosterone than those adhering to a low fat diet" - [Nutra USA]

Neat Tech Stuff / "How To's":

Withings' sleep apnea-detecting smartwatch is the first of its kind - CNET video

I think this is last year's model:

Health Focus (Alzheimer's Disease):