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Anti-aging Research > Doxycycline
Doxycycline
Where to purchase:
News & Research:
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Scientists reverse aging-associated skin wrinkles and hair loss in a mouse
model - Science Daily, 7/20/18 - "The mutation
in the mouse model is induced when the antibiotic doxycycline is added to
the food or drinking water. This causes depletion of mitochondrial DNA
because the enzyme to replicate the DNA becomes inactive ... In four weeks,
the mice showed gray hair, reduced hair density, hair loss, slowed movements
and lethargy, changes that are reminiscent of natural aging. Wrinkled skin
was seen four to eight weeks after induction of the mutation, and females
had more severe skin wrinkles than males ... Dramatically, this hair loss
and wrinkled skin could be reversed by turning off the mutation. The photos
below show the hair loss and wrinkled skin after two months of doxycycline
induction, and the same mouse a month later after doxycycline was stopped,
allowing restoration of the depleted mitochondrial DNA" - Note:
I threw this in because if doxycycline will accelerate aging, maybe other
antibiotics might.
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Vitamin C and antibiotics: A new one-two 'punch' for knocking-out cancer
stem cells - Science Daily, 5/12/17 - "The
Salford team recently showed Vitamin C to be up to ten times more effective
at stopping cancer cell growth than pharmaceuticals such as 2-DG, but they
say that when Vitamin C is combined with an antibiotic, it is up to ten
times more effective, making it nearly 100 times more effective than 2-DG
... As Doxycycline and Vitamin C are both relatively non-toxic, this could
dramatically reduce the possible side-effects of anti-cancer therapy ... The
Salford team also identified eight other drugs that could be used as a
"second-punch" after the antibiotic regime, including berberine (a natural
product) -- and a number of cheap non-toxic FDA approved drugs" - See
American Health Products - Ester C W/Citrus Bioflavonoids, 1000 mg, 180 veg tablets at Amazon.com
 .
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Single Mechanism For Hypertension, Insulin Resistance And Immune Suppression
- Science Daily, 6/30/08 - "spontaneously
hypertensive rat (SHR) ... protein receptors on the surface of SHR cells
become clipped off as the animals develop hypertension. They used a novel
visualization technique to show that after several weeks of ingesting
doxycycline in their drinking water, the SHR rats developed cells that again
bristled with normal CD18 and insulin receptors. The animals' metabolic
conditions simultaneously improved; blood pressure normalized and symptoms
of immune suppression disappeared" - Note: I was taking Periostat
(low dose doxycycline, 20 mg) for two reasons, the help prevent gum disease
and to lower CRP. Now I have a third reason. See
doxycycline at OffshoreRx1.com
(you can use a pill cutter to quarter the pills).
- Doxycycline May
Slow Progression of Knee Osteoarthritis
- Medscape, 7/1/06 - "Rate of loss of joint space
was 40% less in the doxycycline group vs placebo at 16 months"
- The Promise of a
Tetracycline Antibiotic for OA - Medscape, 8/22/05
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Doxycycline May Slow Progression of Knee Osteoarthritis - Medscape,
7/1/05
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The Promise of Tetracycline Antibiotic, Doxycycline, for Treating
Osteoarthritis - Doctor's Guide, 6/28/05 -
"doxycycline may slow the progression of joint
damage"
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First-Time Generic Approvals: Periostat, TriCor, Foscavir - Medscape,
6/21/05 - "On May 13, the FDA approved a first-time
generic formulation of doxycycline hyclate 20-mg tablets ... Doxycycline
hyclate tablets are indicated for use as an adjunct to scaling and root
planing to promote attachment level gain and to reduce pocked depth in
patients with adult periodontitis"
- Doxycycline-Induced
Photo-Onycholysis - Medscape, 1/19/04
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Antibiotics May Temporarily Stave Off Alzheimer's Disease Symptoms -
Doctor's Guide, 10/15/03 -
"The antibiotics doxycycline and rifampin may have a
therapeutic role in temporarily slowing the progression of Alzheimer's
disease symptoms"
- Antibiotics May
Slow Alzheimer's - WebMD, 10/9/03
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Antibiotics May Ease Alzheimer's Symptoms - HealthDay, 10/9/03 -
"The team assigned them randomly to a group that
received 200 milligrams of the antibiotic doxycycline and 300 milligrams of
rifampin daily for three months ... The magnitude of the difference was
similar to the effects seen with therapy with cholinesterase inhibitors"
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Acne Therapy, Adoxa (Doxycycline), Now Available In 75 Mg Option In US -
Doctor's Guide, 6/3/03
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I have used Periostat for gum disease for nine months. I feel that my teeth
are now well rooted in my gums. I understand that I should now stop taking
Periostat. What will happen when I will stop?
- Intelihealth Ask the Expert
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Subantimicrobial Doxycycline Tablets Effective Against Moderate Acne -
Doctor's Guide, 5/2/03
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Low-dose Periostat (Doxycycline) Shows Benefits in Patients with Heart
Failure - Doctor's Guide, 11/20/02 -
"At six-month follow-up, sub-antimicrobial dose
doxycyline significantly reduced
CRP levels by 45.8 percent compared to baseline values (p<0.05). The
drug was also associated with a 33.5 percent reduction in interleukin-6 and
a 50 percent reduction in metalloproteinase ... The findings are exciting,
since research is now showing that CRP is both a key marker of inflammation
leading to future acute coronary events, but also that CRP itself may
contribute to the initiation and progression of atherosclerosis"
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Blood Protein Predicts Stroke Risk - HealthDay, 6/23/03 -
"whether the substance [CRP] is an independent
risk factor for these episodes or merely a reflection of narrowed and
crumbling arteries hasn't been entirely clear ... New research now
suggests that the molecule, called
C-reactive protein (CRP), is indeed its own oddsmaker ... The
cholesterol-fighting drugs known as
statins have been shown to lower CRP by about 25 percent or so,
Stein says. However, it's not clear that that effect reduces
cardiovascular trouble or increases survival"
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Dog's tale of survival opens door in cancer research - USA Today,
7/24/02 -
"The treatment is a cocktail of so-called
anti-angiogenic drugs, which have been widely researched for more than a
decade and work by starving tumors of their blood supply. Researchers say
the three-drug combination, which Haber mixed into Navy's regular dog food,
targets the cancer from many angles ...
When researchers heard that Navy was cancer-free after receiving a cocktail
of drugs already approved by the Food and Drug Administration —
Celebrex, tamoxifen
(sold as Nolvadex) and doxycycline — the treatment became known as the Navy
Protocol ... Navy's treatment, though experimental, cost $2,000"
- Doxycycline Inhibits
Non-Small Cell Lung Cancer Growth - Doctor's Guide, 11/3/99
Abstracts:
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Doxycycline inhibits the adhesion and migration of melanoma cells by
inhibiting the expression and phosphorylation of focal adhesion kinase (FAK)
- Cancer Lett. 2009 May 29 - "doxycycline inhibits
the adhesion and migration of melanoma cells. Afterwards, the cells undergo
apoptosis (aniokis). Remarkably, doxycycline also inhibits the expression
and phosphorylation of focal adhesion kinase (FAK), a protein tyrosine
kinase involved in the regulation of cell adhesion and migration. We further
demonstrate that doxycycline down-regulates the activities of MMP-2 and
MMP-9, and its effects are stronger than those of an Integrin beta1
antibody. Finally, we suggest that doxycycline might exert its anti-tumor
effects by inhibiting FAK signaling pathway. These results provide an
insight into the possible mechanisms that underlie the multiple drug actions
of doxycycline. The potential use of doxycycline in anti-tumor treatment is
promising and warrants further studies"
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Doxycycline: A Pilot Study to Reduce Diabetic Proteinuria - Am J
Nephrol. 2007 Apr 12;27(3):269-273 - "Mean (+/-SD)
24-hour urine protein was 888 +/- 419 mg at baseline, 884 +/- 368 mg after 1
month, and 643 +/- 386 mg after the 2 months of doxycycline treatment"
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