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Home > Health
Conditions > Brain-derived neurotrophic factor (BDNF)
Brain-derived neurotrophic factor (BDNF)
Alternative News:
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Cordycepin buffers
anisomycin-induced fear memory deficit by restoring hippocampal BDNF-
Biochem Biophys Res Commun 2023 May 3 - "The process
of memory consolidation involves the synthesis of new proteins, and
interfering with protein synthesis through anisomycin can impair memory.
Memory deficits due to aging and sleep disorders may also result from a
reduction in protein synthesis. Rescuing memory deficits caused by protein
synthesis deficiency is therefore an important issue that needs to be
addressed ... We observed that cordycepin was able to attenuate these
deficits and restore BDNF levels in the hippocampus. The behavioral effects
of cordycepin were dependent on the BDNF/TrkB pathway, as demonstrated by
the use of ANA-12. Cordycepin had no significant impact on locomotor
activity, anxiety or fear memory. Our findings provide the first evidence
that cordycepin can prevent anisomycin-induced memory deficits by regulating
BDNF expression in the hippocampus" - See
cordycepin at Amazon.com.
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Can 6 Minutes of Intense
Cycling Put the Brakes on Alzheimer's? - Medscape, 1/12/23 - "In
a small study of healthy adults, 6 minutes of high-intensity cycling increased
circulating levels of brain-derived neurotrophic factor (BDNF) to a
significantly greater extent than prolonged light cycling or fasting ... Both
intermittent fasting and exercise have previously been shown to have potent
neuroprotective effects; and an acute upregulation of BDNF appears to be a
common mechanistic link"
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The effects of rutin
flavonoid supplement on glycemic status, lipid profile, atherogenic index of
plasma, brain-derived neurotrophic factor (BDNF), some serum inflammatory, and
oxidative stress factors in patients with type 2 diabetes mellitus: A
double-blind, placebo-controlled trial - Phytother Res 2022 Sep 13 -
"randomized and supplemented with 500 mg rutin or
placebo per day for 3-months ... The results showed a significant decrease in
FBG, insulin, HbA1c, HOMO-IR, LDL-c, TG, VLDL, CHOL, LDL-c.HDL-c ratio, AIP,
IL-6, and MDA and a significant increase in HDL-c, QUICKI index, BDNF, and TAC
compared with the initial value (p for all <.05). In the adjusted model, the
mean changes of FBG, insulin, HbA1c, HOMO-IR, LDL-c, CHOL, LDL.HDL ratio, AIP,
MDA, and IL-6 were significantly lower and mean changes of QUICKI index, HDL-c,
and TAC were significantly higher in the rutin group compared with the placebo
group (adjusted p for all <.05). It seems that rutin may have beneficial effects
on improving metabolic parameters, BDNF, and inflammatory and oxidative stress
factors in T2DM patients" - See rutin at Amazon.com.
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Effects of melatonin
supplementation on BDNF concentrations and depression: A systematic review and
meta-analysis of randomized controlled trials - Behav Brain Res 2022 Aug 29
- "The aim of this comprehensive systematic review and
meta-analysis was to evaluate the beneficial effects of melatonin
supplementation on brain-derived neurotrophic factor (BDNF) concentration and
clinical depressive disorder ... Melatonin supplementation yielded no
significant effect on BDNF concentration (WMD: -5.61; 95% CI: -14.10, 2.88;
I-square: 85.6%), but improved depression by decreasing the score (WMD: -0.76
... The subgroup analysis showed that melatonin supplementation had a
significant decreasing effect on BDNF levels in doses ≤ 10mg/day, with more than
4 weeks of duration, and in men" - See
melatonin at Amazon.com.
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Probiotics supplementation
and brain-derived neurotrophic factor (BDNF): a systematic review and
meta-analysis of randomized controlled trials - Nutr Neurosci 2022 Aug 22 -
"Overall, meta-analysis of 11 trials (n = 648
participants) showed no significant changes in serum level of BDNF following
probiotics. However, subgroup analysis revealed that probiotics increased BDNF
levels in individuals suffering from neurological disorders (n = 214
participants; WMD = 3.08 ng/mL, 95% CI: 1.83, 4.34; P = 0.001; I2 = 7.5%;
P-heterogeneity 0.34), or depression (n = 268 participants; WMD = 0.77 ng/mL,
95% CI: 0.07, 1.47; P = 0.032; I2 = 88.4%; P-heterogeneity < 0.001).
Furthermore, a significant increase in BDNF levels was found in studies that
administered the mixture of Lactobacillus and Bifidobacterium genera, and were
conducted in Asia" - See probiotic supplements at Amazon.com.
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Circulating Human Serum
Metabolites Derived from the Intake of a Saffron Extract (Safr'Inside TM)
Protect Neurons from Oxidative Stress: Consideration for Depressive Disorders
- Nutrients 2022 Apr 5 - "Increases in oxidative stress
have been reported to play a central role in the vulnerability to depression,
and antidepressant drugs may reduce increased oxidative stress in patients.
Among the plants exerting anti-inflammatory and anti-oxidant properties,
saffron, a spice derived from the flower of Crocus sativus, is also known for
its positive effects on depression, potentially through its SSRI-like properties
... we demonstrated for the first time that the circulating human metabolites
produced following saffron intake (Safr'InsideTM) protect human neurons from
oxidative-stress-induced neurotoxicity by preserving cell viability and
increasing BNDF production. In particular, the metabolites significantly
stimulated both dopamine and serotonin release. In addition, the saffron's
metabolites were also able to protect serotonergic tone by inhibiting the
expression of the serotonin transporter SERT and down-regulating serotonin
metabolism" - See saffron supplements at Amazon.com.
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The effects of wheat germ
consumption on mental health and brain-derived neurotrophic factor in subjects
with type 2 diabetes mellitus: a randomized, double-blind, placebo-controlled
trial - Nutr Neurosci 2021 May 13 - "Eighty
participants with T2DM were randomly allocated to receive 20 g wheat germ (n =
40) or placebo (n = 40) in a randomized double-blind clinical trial for 12 weeks
... a significant increase in serum BDNF concentrations was observed in the
wheat germ group ... wheat germ consumption for 12 weeks could significantly
reduce the stress and depression scores but had no significant effects on
anxiety scale and anthropometric outcomes in patients with T2DM" - See
wheat germ at Amazon.com.
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Effects of a Psychobiotic Supplement on Serum Brain-derived Neurotrophic Factor
Levels in Depressive Patients: A Post Hoc Analysis of a Randomized Clinical
Trial - J Neurogastroenterol Motil 2020 Sep 30 - "Psychobiotics
are probiotics or prebiotics that, upon ingestion in adequate amounts, yield
positive influence on mental health via microbiota-gut-brain axis regulation to
modulate the circulating cytokines, chemokines, neurotransmitters, or
neurotrophins levels. We have recently shown that a psychobiotic combination
(Lactobacillus helveticus R0052 and Bifidobacterium longum R0175; CEREBIOME)
significantly improved depression symptoms in patients with depression. Recent
animal data suggest the influence of the gut microbiota on brain-derived
neurotrophic factor (BDNF), which was shown to correlate with antidepressant
response in depressive patients. Therefore, we conducted this exploratory post
hoc analysis of BDNF levels to clarify the mechanism of action of this
psychobiotic in our cohort ... We compared serum BDNF levels from participants
at baseline and endpoint, and assessed the Pearson correlation between
depression severity and BDNF levels for each intervention ... We found that
post-intervention BDNF levels were significantly different between groups (P <
0.001). Furthermore, BDNF levels increased significantly in the probiotic group
compared to both the prebiotic (P < 0.001) and placebo" - [Nutra
USA] - See probiotic supplements at Amazon.com
and
iHerb and prebiotic supplements at
Amazon.com and
prebiotic supplements at iHerb.C
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o-Administration of Iron and a Bioavailable Curcumin Supplement Increases Serum BDNF Levels in Healthy Adults
- Antioxidants (Basel) 2020 Jul 22 - "Brain-derived
neurotrophic factor (BDNF) is key for the maintenance of normal neuronal
function and energy homeostasis and has been suggested to improve cognitive
function, including learning and memory. Iron and the antioxidant curcumin have
been shown to influence BDNF homeostasis ... Participants were randomly
allocated to five different treatment groups: both iron and curcumin placebo
(FS0+Plac), low dose iron and curcumin placebo (FS18+Plac), low dose iron and
curcumin (FS18+Curc), high dose iron and curcumin placebo (FS65+Plac) and high
dose iron and curcumin (FS65+Curc). Results showed a significant increase in
BDNF over time (26%) in the FS18+Curc group (p = 0.024), and at end-point
between FS18+Curc and FS18+Plac groups (35%, p = 0.042), demonstrating for the
first time that the combination with curcumin, rather than iron supplementation
alone, results in increased serum BDNF. The addition of curcumin to iron
supplementation may therefore provide a novel approach to further enhance the
benefits associated with increased BDNF levels" - [Nutra
USA] - See iron supplements at Amazon.com and
iHerb and curcumin at Amazon.com and
iHerb.
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Effects of Long-Term
Administration of Multi-Strain Probiotic on Circulating Levels of BDNF, NGF,
IL-6 and Mental Health in Patients With Multiple Sclerosis: A Randomized,
Double-Blind, Placebo-Controlled Trial - Nutr Neurosci 2020 Jun 5;1-12 -
"Patients were randomized into intervention and control
groups to receive 2 multi-strain probiotic capsules or placebo, daily for six
months ... From baseline to 6 months, probiotic supplementation resulted in a
significant increase in BDNF and a significant reduction in the IL-6 levels (P <
0.001). Our findings revealed that probiotic supplementation compared to placebo
caused a significant improvement in the general health questionnaire-28 (GHQ-28)
(-5.31 ± 4.62 vs. -1.81 ± 4.23; P = 0.002), Beck Depression Inventory-II
(BDI-II) (-4.81 ± 0.79 vs. -1.90 ± 0.96; P = 0.001), Fatigue Severity Scale
(FSS) (-3.81 ± 6.56 vs. 0.24 ± 5.44; P = 0.007) and Pain Rating Index (PRI) ...
Overall, six months of probiotic supplementation resulted in greater improvement
in mental health parameters" - See
probiotic supplements at Amazon.com
and
iHerb.
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Mulberry fruit improves
memory in scopolamine-treated mice: role of cholinergic function, antioxidant
system, and TrkB/Akt signaling - Nutr Neurosci. 2019 Dec 2:1-11 -
"we examined whether mulberry fruit extract (MFE)
protected neuronal cells against oxidative stress-induced neurodegeneration ...
MFE protects neuronal cells against oxidative stress-induced apoptosis through
upregulating the expression of BDNF and antioxidant enzymes by stabilizing the
activation of the TrkB/Akt pathway" - See
mulberry leaf extract.
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Effects of macular
xanthophyll supplementation on brain-derived neurotrophic factor,
pro-inflammatory cytokines, and cognitive performance - Physiol Behav. 2019
Nov 1;211:11265 - "Based on their antioxidant and
anti-inflammatory capacity, we investigated the effect of the dietary
carotenoids lutein and zeaxanthin, along with the zeaxanthin isomer
meso-zeaxanthin (collectively the "macular xanthophylls" [MXans]) on systemic
brain-derived neurotrophic factor (BDNF) and anti-oxidant capacity (AOC), and
the pro-inflammatory cytokines TNF-α, IL-6, and IL-1β ... macular pigment
optical density [MPOD] ... antioxidant capacity (AOC) ... Six months of daily
supplementation with at least 13 mg of MXans significantly reduces serum IL-1β,
significantly increases serum MXans, BDNF, MPOD, and AOC, and improves several
parameters of cognitive performance" - See
lutein at Amazon.com
and
astaxanthin at Amazon.com.
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Protective effects of
vitamin D on neurophysiologic alterations in brain aging: role of brain-derived
neurotrophic factor (BDNF) - Nutr Neurosci. 2019 Sep 16:1-10 -
"Vitamin D
supplementation significantly mitigated the observed aging-related reduction in
brain BDNF level and activities of AChE and antioxidant enzymes and elevation in
malondialdehyde level and caspase-3 activity compared to control groups. Brain
BDNF level correlated positively with serum 25(OH) D level and brain AChE
activity and negatively with brain malondialdehyde level and caspase-3 activity
in supplemented groups. Conclusion: Restoring vitamin D levels may, therefore,
represent a useful strategy for healthy brain aging. Augmenting brain BDNF seems
to be a key mechanism through which vitamin D counteracts age-related brain
dysfunction" - See
vitamin D at Amazon.com.
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Schisandrae Chinensis
Fructus inhibits behavioral deficits induced by sleep deprivation and chronic
unpredictable mild stress via increased signaling of brain-derived neurotrophic
factor - Phytother Res. 2019 Aug 30 - "sleep
deprivation (SD) and Schisandrae Chinensis Fructus (SCF) ... chronic
unpredictable mild stress (CUMS) ... These results indicated that the
antidepressant-like effect of SCF in the CUMS depends on the activation of BDNF
and the modulation of TrkB/CREB/ERK and PI3K/AKT/GSK3β/mTOR signaling cascades,
and SD (12 hr) shared a common etiology consisting of complex bidirectional
interactions with SCF" - See
schizandra at Amazon.com.
Other News:
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Stingless Bee Honey
Improves Spatial Memory in Mice, Probably Associated with Brain-Derived
Neurotrophic Factor (BDNF) and Inositol 1,4,5-Triphosphate Receptor Type 1
(Itpr1) Genes - Evid Based Complement Alternat Med. 2019 Dec 2;2019:8258307
- "This study was conducted to evaluate the effects of
stingless bee honey (SBH) supplementation on memory and learning in mice.
Despite many studies that show the benefits of honey on memory, reports on the
nootropic effects of SBH are still lacking, and their underlying mechanism is
still unclear. SBH is a honey produced by the bees in the tribe of Meliponini
that exist in tropical countries. It features unique storage of honey collected
in cerumen pots made of propolis. This SBH may offer a better prospect for
therapeutic performance as the previous report identifies the presence of
antioxidants that were greater than other honey produced by Apis sp ...Results
indicate spatial working memory and spatial reference memory of mice were
significantly improved in the honey-treated group compared with the control
group. Improved memory consolidations were also observed in prolonged
supplementation. Gene expression analyses of acutely treated mice demonstrated
significant upregulation of BDNF and Itpr1 genes that involve in synaptic
function. NMR analysis also identified phenylalanine, an essential precursor for
tyrosine that plays a role at the BDNF receptor. In conclusion, SBH
supplementation for seven days at 2000 mg/kg, which is equivalent to a human
dose of 162 mg/kg, showed strong capabilities to improve spatial working memory.
And prolonged intake up to 35 days increased spatial reference memory in the
mice model. The phenylalanine in SBH may have triggered the upregulation of BDNF
genes in honey-treated mice and improved their spatial memory performance"
- See stingless bee honey at Amazon.com.
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Brain-derived neurotrophic factor - wikipedia.com -
"BDNF acts on certain neurons of the central nervous
system and the peripheral nervous system, helping to support the survival of
existing neurons, and encourage the growth and differentiation of new
neurons and synapses.[9][10] In the brain, it is active in the hippocampus,
cortex, and basal forebrain—areas vital to learning, memory, and higher
thinking.[11] BDNF is also expressed in the retina, kidney, saliva,
prostate, motor neurons and skeletal muscle.[12][13] ... BDNF itself is
important for long-term memory"
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