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Stomach Cancer
Alternative News:
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Sulforaphane
Targets the TBX15/KIF2C Pathway to Repress Glycolysis and Cell
Proliferation in Gastric Carcinoma Cells - Nutr Cancer
2023;75(4):1263-1270 - "The anti-tumor
effects of sulforaphane were antagonized by down-regulation of
TBX15, up-regulation of KIF2C or addition of a PKM2 agonist.
Sulforaphane can reduce cell proliferation and PKM2-mediated
glycolysis in gastric carcinoma cells, apparently by activating
the TBX15/KIF2C pathway" - See
sulforaphane at Amazon.com.
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Allium
vegetable intake associated with the risk of incident gastric
cancer: a continuous follow-up study of a randomized
intervention trial - Am J Clin Nutr 2023 Jan -
"We found a significant reduction in the
risk of developing GC with increasing dietary intake of allium
vegetables, particularly garlic vegetables. The findings add to
the literature on the potential inverse association of garlic
vegetable intake with the risk of GC, therefore holding public
health implications for dietary recommendations" - See
garlic supplements at Amazon.com.
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Association
of Dietary Antioxidant Vitamin Intake and Gastric Cancer Risk
According to Smoking Status and Histological Subtypes of Gastric
Cancer: A Case-Control Study in Korea - Nutr Cancer 2022 Dec
1 - "This study aimed to determine the
association between dietary antioxidant vitamin intake and GC
risk according to smoking status and the histological subtype
... Dietary information was collected using a quantitative food
frequency questionnaire (FFQ). When stratified by smoking
status, increased intake of vitamin C (OR = 0.38; 95% CI =
0.17-0.84 for highest vs. lowest; P for trend = 0.033) and
folate (OR = 0.28; 95% CI = 0.12-0.64 for highest vs. lowest; P
for trend = 0.003) decreased GC risk in nonsmokers. Vitamin C (P
for interaction = 0.043) and folate (P for interaction =0.015)
levels were significantly associated with smoking status.
Similar results were observed in nonsmokers with diffuse and
mixed types of GC, but not in those with intestinal type of GC.
Therefore, we found an inverse association between higher intake
of dietary vitamin C and folate with the risk of GC among
nonsmokers. These protective associations were strong in
nonsmokers with diffuse and mixed types of GC" - See
vitamin C products at Amazon.com.
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Can Folic
Acid Halt or Reverse Progression of Gastric Precancerous
Conditions? - Medscape, 8/10/22 -
"Folic acid supplementation can improve histopathologic aspects
of gastric precancerous conditions (GPC), including gastric
mucosal atrophy and intestinal metaplasia ... A meta-analysis of
five studies showed a statistically significant positive
treatment effect of folic acid supplementation on gastric
mucosal atrophy (relative risk [RR]: 1.61; 95% CI: 1.07 – 2.41)
... A meta-analysis of two trials showed a statistically
significant effect of folic acid on reversal of intestinal
metaplasia (RR: 1.77; 95% CI: 1.32 – 2.37) ... Our study
indicates that folic acid has a beneficial effect in the
treatment of pathological changes of GPC when the dose was
maintained at 20–30 mg/d and the duration of treatment was
maintained at 3–6 months" - See
folic acid products at Amazon.com.
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Inverse Association between
Dietary Iron Intake and Gastric Cancer: A Pooled Analysis of Case-Control
Studies of the Stop Consortium - Nutrients 2022 Jun 20 -
"Dietary iron is inversely related to GC, with no
difference by subsite or histological type. While the results should be
interpreted with caution, they provide evidence against a direct effect of iron
in gastric carcinogenesis" - See iron supplements at Amazon.com.
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A Specifically Tailored
Multistrain Probiotic and Micronutrient Mixture Affects Nonalcoholic Fatty Liver
Disease-Related Markers in Patients with Obesity after Mini Gastric Bypass
Surgery - J Nutr 2021 Nov 22 - "Nonalcoholic fatty
liver disease (NAFLD) is frequent among patients undergoing bariatric surgery.
Beyond weight reduction, dietary supplements like micronutrients or probiotics
that modify insulin resistance and lipotoxicity can be used to prevent or delay
the progression of liver disease ... Patients received a combination of
specifically tailored multistrain probiotic powder and a specific micronutrient
mixture (Pro+SM) or a control treatment consisting of a placebo and a basic care
micronutrient mixture (Con+BM), with some micronutrients in lower doses than SM,
for 12 wk after hospital discharge ... Compared with Con+BM, Pro+SM improved
serum ASAT (difference: -8.0 U/L, 95% CI: -17.0, -4.0; P = 0.043), NAFLD
fibrosis score (difference: -0.39; 95% CI: -0.78, 0; P = 0.048), serum
triglycerides (difference: -22.8 mg/dL; 95% CI: -45.6, -0.1; P = 0.049) and the
visceral adiposity index (difference: -0.70" - See
probiotic supplements at Amazon.com.
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Serum carnitine as a
biomarker of sarcopenia and nutritional status in preoperative gastrointestinal
cancer patients - J Cachexia Sarcopenia Muscle 2021 Dec 22 -
"Sarcopenia is an important factor in the postoperative
outcome of gastrointestinal cancer patients ... One hundred fourteen patients
scheduled to undergo gastroenterological surgery between August 2016 and January
2017 were enrolled. Their mean age was 68.4 ± 10.5, and 64.9% were male. Serum
carnitine fractions [total carnitine (TC), free l-carnitine (FC), and
acylcarnitine (AC)] were measured prior to surgery ... This study suggests that
carnitine level is a biomarker of sarcopenia and nutritional status" -
See l-carnitine at Amazon.com.
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Pleiotropic nature of
curcumin in targeting multiple apoptotic-mediated factors and related strategies
to treat gastric cancer: A review - Phytother Res 2021 May 24 -
"Gastric cancer (GC) is one of the major reasons for
cancer-associated death and exhibits the second-highest mortality rate
worldwide. Several advanced approaches have been designed to treat GC; however,
these strategies possess many innate complications. In view of this, the
upcoming research relying on natural products could result in designing
potential anticancer agents with fewer side effects. Curcumin, isolated from the
rhizomes of Curcuma longa L. has several medicinal properties like
antiinflammatory, antioxidant, antiapoptotic, antitumor, and antimetastatic.
Such pleiotropic nature of curcumin impedes the invasion and proliferation of GC
by targeting several oncogenic factors like p23, human epidermal factor
receptor2 including Helicobacter pylori. The side effect of chemotherapy, that
is, chemotherapeutic resistance and radiotherapy could be reduced combination
therapy of curcumin. Moreover, the photodynamic therapy of curcumin destroys the
cancer cells without affecting normal cells. However, further more potential
studies are required to establish the potent efficacy of curcumin in the
treatment of GC" - See curcumin at Amazon.com.
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Effects of Berberine on
Circular RNA Expression Profiles in Human Gastric Cancer Cells - Evid Based
Complement Alternat Med 2021 May 4 - "Our results
demonstrate that berberine has the potential to influence cancer-related
pathways by regulating circRNA expression and their corresponding target genes
in GC cells" - See berberine at Amazon.com.
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Ginsenoside Rg3 (Shenyi
Capsule) Combined with Chemotherapy for Digestive System Cancer in China: A
Meta-Analysis and Systematic Review - Evid Based Complement Alternat Med.
2019 Dec 17 - "Ginsenoside Rg3 combined with
chemotherapy can improve the clinical efficacy and alleviate treatment-induced
side effects for digestive system cancer" - See
ginseng at Amazon.com.
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Statins were associated
with a reduced gastric cancer risk in patients with eradicated Helicobacter
pylori infection: a territory-wide propensity score matched study - Biol
Pharm Bull. 2019;42(12):2002-2008 - "statins were
associated with a lower GC risk (SHR 0.34; 95% CI:0.19-0.61), in a duration- and
dose-response manner"
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Associations between
calcium and magnesium intake and the risk of incident gastric cancer, a
prospective cohort analysis of the NIH-AARP Diet and Health Study - Int J
Cancer. 2019 Aug 31 - "We used Cox proportional hazard
modeling to estimate the association between calcium and magnesium intakes with
risk of incident gastric adenocarcinoma (GA) overall and by anatomic location,
noncardia (NCGA) and cardia (CGA). A total of 536,403 respondents (59% males,
41% females) were included for analysis, among whom 1,518 incident GAs (797
NCGA, 721 CGA) occurred. Increasing calcium intake was associated with lower
risk of GA overall (p-trend = 0.05), driven primarily by the association with
NCGA, where above median calcium intakes were associated with a 23% reduction in
risk compared to the lowest quartile (p-trend = 0.05). This magnitude of NCGA
risk reduction was greater among non-white races and Hispanics (HR 0.51, 95% CI:
0.24-1.07, p-trend = 0.04), current/former smokers (HR 0.58, 95% CI: 0.41-0.81),
obese individuals (HR 0.54,95% CI: 0.31-0.96), and those with high NCGA risk
scores (HR 0.50, 95% CI: 0.31-0.80). Among men only, increasing magnesium intake
was associated with 22-27% reduced risk of NCGA (p-trend = 0.05), while for the
cohort, dietary magnesium intake in the highest versus lowest quartile was
associated with a 34% reduced risk of NCGA (HR 0.66, 95% CI: 0.48-0.90). These
findings have important implications for risk factor modification and
personalized prevention" - See
magnesium supplements at Amazon.com.
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Anti-tumor activity of curcumin on stomach cancer - Science Daily, 4/22/19 -
"In addition to curcumin, other compounds found to play
a key role in modulating histone activity were cholecalciferol, resveratrol
(present mainly in grape seeds and red wine), quercetin (abundant in apples,
broccoli and onions), garcinol (isolated from the bark of the kokum tree,
Garcinia indica), and sodium butyrate (produced by gut bacteria via fermentation
of dietary fiber) ... "These compounds can favor the activation or repression of
genes involved in the development of stomach cancer by promoting or inhibiting
histone acetylation," Calcagno said ... Curcumin, for example, influences
histone modifications primarily by inhibiting HATs and HDACs to suppress cancer
cell proliferation and induce apoptosis (programmed cell death). Garcinol, whose
chemical structure resembles that of curcumin, inhibits HATs and helps prevent
stomach cancer by neutralizing free radicals" - See
curcumin products at Amazon.com.
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Antioxidant intake
from diet and supplements and risk of digestive cancers in middle-aged
adults: results from the prospective NutriNet-Santé cohor - Br J Nutr.
2017 Sep 20:1-9 - "This prospective cohort study
with quantitative assessment of supplemental intakes suggests a potential
protective effect of several antioxidants (vitamins C and E and Se) on
digestive cancer risk, and a modulation of some of these relationships by
alcohol consumption and smoking status"
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Tomato extract fights stomach cancer, ripe for further study - Science
Daily, 5/13/17 - "whole tomato extracts from two
different Southern Italy cultivars inhibit gastric cancer cell growth and
malignant features ... Treatment with the whole tomato extracts affected key
processes within the cells hindering their migration ability, arresting cell
cycle through the modulation of retinoblastoma family proteins and specific
cell cycle inhibitors, and ultimately inducing cancer cell death through
apoptosis" - See
Jarrow Lyco-Sorb (contains Lyco-O-Mato) at Amazon.com.
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Meta-Analysis: Does Garlic Intake Reduce Risk of Gastric Cancer? - Nutr
Cancer. 2014 Nov 20:1-11 - "Garlic contains numerous
sulfide compounds, including diallyl trisulfide, which have anticarcinogenic
properties. We conducted a meta-analysis to determine if garlic intake
reduces the risk of gastric cancer ... High, low, and any garlic intake were
all associated with reduced risk of gastric cancer. High intake had the most
significant risk reduction, OR = 0.49 (95% CI: 0.38-0.62). Heterogeneity was
low (I2 = 30.85, P = 0.17). A more modest risk reduction was associated with
low intake, OR = 0.75 (95% CI: 0.58-0.97). Half of the studies did not
separate garlic intake into high or low amounts, intake was only noted as
consumption vs. non-consumption. Any amount of consumption still showed a
risk reduction similar to low intake, OR = 0.77 (95% CI: 0.60-1.00). Low and
any amount of consumption showed moderate heterogeneity (58% and 45%,
respectively)" - See
garlic supplements at Amazon.com.
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Involvement of BID Translocation in Glycyrrhetinic Acid and 11-Deoxy
Glycyrrhetinic Acid-Induced Attenuation of Gastric Cancer Growth - Nutr
Cancer. 2014 Feb 18 - "Glycyrrhetinic acid (GA), the
main chemical constituents of licorice, has shown remarkable anticancer
activity. However, the side effects limit its widespread use. 11-DOGA is
produced through reduction of GA 11-carbonyl to 11-hydroxyl to reduce its
side effects, although its anticancer activities are largely unknown. Here,
we report that the functional mechanisms of GA and 11-DOGA in gastric
cancers, as well as the comparison between these two drugs' pharmacological
potential. Firstly, we found that GA and 11-DOGA significantly inhibits the
viabilities of gastric cancer cells in dose- and time-dependent manners.
Both GA and 11-DOGA induce gastric cancer cells apoptosis and cell cycle
arrest in G2 phase by upregulation of p21 and downregulation of cdc2 and
cyclin B1. Further studies show that GA and 11-DOGA-induced apoptosis in
gastric cancer cells is associated with BID translocation from nucleus to
mitochondria. Moreover, GA and 11-DOGA could effectively inhibit tumor
formation of gastric cancer cells in nude mice" -
Note: One of those side effects is
that licorice increases cortisol which is not good for most people.
See
licorice supplements at Amazon.com.
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Physical
Activity is Associated with Reduced Risk of Gastric Cancer: A Systematic Review
and Meta-Analysis - Cancer Prev Res (Phila). 2013 Sep 18 -
"Meta-analysis demonstrated that the risk of gastric
cancer was 21% lower among the most physically active people as compared with
the least physically active people"
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Prediagnostic plasma vitamin C and risk of gastric adenocarcinoma and esophageal
squamous cell carcinoma in a Chinese population - Am J Clin Nutr. 2013 Sep
11 - "China has some of the highest incidence rates for
gastric adenocarcinoma (GA) and esophageal squamous cell carcinoma (ESCC) in the
world ... Two cohort studies and the current study were included to assess the
body of evidence ... For GA, each 20-μmol/L increase in plasma vitamin C was
associated with a 14% decrease in risk ... Compared with individuals with low
plasma vitamin C concentrations (≤28 μmol/L), those with normal concentrations
(>28 μmol/L) had a 27% reduced risk of GA ... No association between vitamin C
concentrations and ESCC was seen" - See
Jarrow Formulas, C 1000, Ascorbic Acid + Oleaselect Olive Fruit Extract, 250
Veggie Caps.
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Inhibitory
effects of isoflavones on tumor growth and cachexia in newly established
cachectic mouse models carrying human stomach cancers - Nutr Cancer.
2013;65(4):578-89 - "Isoflavone treatment on the models
induced tumor cytostasis, attenuation of cachexia, and prolonged survival
whereas discontinuation of the treatment resulted in progressive tumor growth
and weight loss" - See
soy isoflavones at Amazon.com.
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Green tea found to reduce rate of some GI cancers - Science Daily,
10/31/12 - "the investigators surveyed women
enrolled in the Shanghai Women's Health Study, a population-based study of
approximately 75,000 middle-aged and older Chinese women ... regular tea
consumption, defined as tea consumption at least three times a week for more
than six months, was associated with a 17 percent reduced risk of all
digestive cancers combined. A further reduction in risk was found to be
associated with an increased level of tea drinking. Specifically, those who
consumed about two to three cups per day (at least 150 grams of tea per
month) had a 21 percent reduced risk of digestive system cancers ... For all
digestive system cancers combined, the risk was reduced by 27 percent among
women who had been drinking tea regularly for at least 20 years ... For
colorectal cancer, risk was reduced by 29 percent among the long-term tea
drinkers. These results suggest long-term cumulative exposure may be
particularly important ... Tea contains polyphenols or natural chemicals
that include catechins like EGCG and ECG. Catechins have antioxidant
properties and may inhibit cancer by reducing DNA damage and blocking tumor
cell growth and invasion" - See
green tea extract at Amazon.com.
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Dietary
flavonoid and lignan intake and gastric adenocarcinoma risk in the European
Prospective Investigation into Cancer and Nutrition (EPIC) study - Am J
Clin Nutr. 2012 Oct 17 - "gastric cancer (GC)
...followed 477,312 subjects (29.8% men) aged 35-70 y from 10 European
countries who participated in the European Prospective Investigation into
Cancer and Nutrition (EPIC) study. Validated dietary questionnaires and
lifestyle information were collected at baseline ... average follow-up of 11
y ... We observed a significant inverse association between total flavonoid
intake and GC risk in women (HR: 0.81; 95% CI: 0.70, 0.94; for the
continuous variable after log(2) transformation) but not in men (HR: 0.97;
95% CI: 0.85, 1.09). In women, significant inverse associations with GC risk
were also observed for intakes of some flavonoid subgroups (anthocyanidins,
flavonols, flavones, and flavanols), particularly with intestinal type
tumors for total flavonoid and flavanol intakes" - See
Garden of Life, Radical Fruits Antioxidant Complex at Amazon.com.
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Prospective cohort study of tea consumption and risk of digestive system
cancers: results from the Shanghai Women's Health Study - Am J Clin
Nutr. 2012 Oct 10 - "We used the Shanghai Women's
Health Study, a population-based prospective cohort study of middle-aged and
older Chinese women who were recruited in 1996-2000 ... In comparison with
women who never drank tea, regular tea intake (mostly green tea) was
associated with reduced risk of all digestive system cancers combined (HR:
0.86; 95% CI: 0.74, 0.98), and the reduction in risk increased as the amount
and years of tea consumption increased (P-trend = 0.01 and P-trend < 0.01,
respectively). For example, women who consumed ≥150 g tea/mo (~2-3 cups/d)
had a 21% reduced risk of digestive system cancers combined (HR: 0.79; 95%
CI: 0.63, 0.99). The inverse association was found primarily for colorectal
and stomach/esophageal cancers" - See
green tea extract at Amazon.com.
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Fifteen-Year Effects of Helicobacter pylori, Garlic, and Vitamin Treatments
on Gastric Cancer Incidence and Mortality - J Natl Cancer Inst. 2012 Jan
23 - "Garlic and vitamin treatments were associated
with non-statistically significant reductions in gastric cancer incidence
and mortality. Vitamin treatment was associated with statistically
significantly fewer deaths from gastric or esophageal cancer, a secondary
endpoint (HR = 0.51, 95% CI = 0.30 to 0.87; P = .014)"
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Dietary
total antioxidant capacity and gastric cancer risk in the european
prospective investigation into cancer and nutrition study - Int J
Cancer. 2011 Nov 9 - "A high intake of dietary
antioxidant compounds has been hypothesized to be an appropriate strategy to
reduce gastric cancer (GC) development. We investigated the effect of
dietary Total Antioxidant Capacity (TAC) in relation to GC in the European
Prospective Investigation into Cancer (EPIC) study including 23 centers in
10 European countries ... Dietary antioxidant intake is associated with a
reduction in the risk of GC for both FRAP (adjusted HR 0.66; 95%CI
(0.46-0.95) and TRAP (adjusted HR 0.61; 95%CI (0.43-0.87) (highest vs.
lowest quintile). The association was observed for both cardia and non
cardia cancers. A clear effect was observed in smokers with a significant
reduction in GC risk for the 5(th) quintile of intake for both assays
(highest vs. lowest quintile: adjusted HR 0.41; 95%CI (0.22-0.76) p for
trend <0.001 for FRAP; adjusted HR 0.52; 95%CI (0.28-0.97) p for trend
<0.001 for TRAP) but not in never smokers. In former smokers the association
with FRAP intake was statistically significant (highest vs. lowest quintile:
adjusted HR 0.4; 95%CI (0.21-0.75) p<0.05); no association was observed for
TRAP"
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Flavonoids, proanthocyanidins, and the risk of stomach cancer - Cancer
Causes Control. 2010 Jun 3 - "Strong inverse
relations were found for proanthocyanidins. The OR was 0.44 (95% CI,
0.25-0.76) for monomers and dimers combined and 0.36 (95% CI, 0.21-0.63) for
polymers with three or more mers. Further adjustment for fruit and
vegetables, or vitamin C, did not materially change these associations. This
is the first epidemiological study to suggest that dietary proanthocyanidins
have a favorable role on gastric cancer risk"
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Mediterranean Diet
Linked to Lower Risk for Stomach Cancer - Medscape, 12/29/09 -
"For every 1-unit increase in relative Mediterranean
diet score, the risk for gastric adenocarcinoma decreased by 5% to 7%"
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Citrus
fruit and cancer risk in a network of case-control studies - Cancer
Causes Control. 2009 Oct 24 - "The ORs for the
highest versus lowest category of citrus fruit consumption were 0.47 (95%
confidence interval, CI, 0.36-0.61) for oral and pharyngeal, 0.42 (95% CI,
0.25-0.70) for esophageal, 0.69 (95% CI, 0.52-0.92) for stomach, 0.82 (95%
CI, 0.72-0.93) for colorectal, and 0.55 (95% CI, 0.37-0.83) for laryngeal
cancer"
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Study: 88% of GI Cancer Patients Deficient in Vitamin D -
oncologystat.com, 7/6/09 - "At baseline, the
prevalence of vitamin D deficiency was nearly 88%, including 61% of patients
who met criteria for moderate to severe deficiency"
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Coffee,
black tea and risk of gastric cancer - Cancer Causes Control. 2009 May
12 - "Our investigation, based on a uniquely large
dataset, provides convincing evidence that coffee and black tea consumption
is unlikely to be strongly associated with gastric cancer risk"
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Reductions In Cancer And Overall Mortality Persist 10 Years After Vitamin
And Mineral Supplementation - Science Daily, 4/2/09 - "Individuals
who took a dietary supplement called "factor D", which included selenium,
vitamin E, and beta-carotene, continued to have lower gastric cancer and
overall mortality 10 years after supplementation ceased compared with
individuals who did not take the supplements ... Individuals who took factor
D continued to show benefits, with a 5% reduction in overall mortality (from
a cumulative mortality of 33.62% of participants not taking factor D to
32.19% of participants taking factor D) and an 11% reduction in gastric
cancer mortality (from a cumulative gastric cancer mortality of 4.28% in the
no-factor D group to 3.84% in the factor D group)"
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Grape Extracts May Be Effective Against Harmful Gut Bacteria - Science
Daily, 3/4/09 - "H. pylori is the bacterial agent
most commonly associated with peptic ulcers, gastritis, mucosa-associated
lymphoid tissue lymphoma, and gastric cancer ... The antibacterial effects
of extracts from red, white, black and muscadine grapes as well as the pure
compounds resveratrol, ellagic acid, and myricetin were tested for anti-H.
pylori activity using agar dilution, laser scanning microscopy and cell
proliferation. Following 24 hour treatment, results showed that muscadine
grape skin extract had the highest anti-H. pylori effect, followed by
muscadine grape synergy and seed extract. Additionally, two of the three
compounds, resveratrol and ellagic acid, also inhibited H. pylori" -
See
grape seed extract at Amazon.com
and
resveratrol products at Amazon.com.
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Calcium May Cut Cancer Risk - WebMD, 2/23/09 -
"older men and women who got the most calcium from food and supplements had
a 16% lower risk of colorectal and other cancers of the digestive system
than those who got the least calcium"
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Effects of aqueous green tea extract on activities of DNA turn-over enzymes
in cancerous and non-cancerous human gastric and colon tissues - Altern
Ther Health Med. 2008 May-Jun;14(3):30-3 - "Our data
suggest that green tea may support the medical treatment of stomach and
colon cancer" - See
green tea extract at Amazon.com.
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Green tea extract's Janus Effect on stomach health: study - Nutra USA,
2/12/08 - "The green tea polyphenol
(-)-epicatechin-3-gallate (ECG) may slash the risk of gastric cancer among
women by 75 per cent" - See
green tea extract at Amazon.com.
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Fiber intake and risk of adenocarcinomas of the esophagus and stomach -
Cancer Causes Control. 2007 Jun 12 - "Compared to
subjects in the lowest quartile of fiber intake,
subjects in the highest quartile of intake showed odd ratios of 0.44 (95% CI
= 0.26-0.76) for esophageal adenocarcinoma (P trend = 0.004) and 0.58 (95%
CI = 0.38-0.88) for gastric cardia adenocarcinoma ... High intake of fiber
was associated with significant reduced risks of esophageal and gastric
cardia
adenocarcinoma"
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Cereal fiber intake may reduce risk of gastric adenocarcinomas: The
EPIC-EURGAST study - Int J Cancer. 2007 Jun 20 -
"There was a strong inverse association for diffuse [HR 0.43, 0.22-0.86],
but not intestinal type [HR 0.98, 0.54-1.80] tumors"
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Vitamin A, retinol, and carotenoids and the risk of gastric cancer: a
prospective cohort study - Am J Clin Nutr. 2007 Feb;85(2):497-503 -
"During a mean 7.2-y follow-up, 139 incident cases
of gastric cancer were diagnosed. High intakes of vitamin A and retinol from
foods only (dietary intake) and from foods and supplements combined (total
intake) and of dietary alpha-carotene and beta-carotene were associated with
a lower risk of gastric cancer. The multivariate relative risks for the
highest versus lowest quartiles of intake were 0.53 (95% CI: 0.32, 0.89; P
for trend = 0.02) for total vitamin A, 0.56 (95% CI: 0.33, 0.95; P for trend
= 0.05) for total retinol, 0.50 (95% CI: 0.30, 0.83; P for trend = 0.03) for
alpha-carotene, and 0.55 (95% CI: 0.32, 0.94; P for trend = 0.07) for
beta-carotene"
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Broccoli fights cancer-causing bacteria in humans - Nutra USA, 11/3/05
-
Vitamin C May Protect Against Ulcer-Causing Bacteria - Doctor's Guide,
8/1/03 -
"the lower the level of
vitamin C in the blood the more likely a person
will become infected by Helicobacter pylori, the bacteria that can cause
peptic ulcers and stomach cancer ... The bottom line is that higher
levels of vitamin C may have the potential to prevent peptic ulcers and
stomach cancer"
- Broccoli Beats
Ulcers, Cancer - WebMD, 5/28/02
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Nutrients May Influence Risk Of Stomach And Esophageal Cancer -
Intelihealth, 11/8/01 -
"patients who consumed high amounts of fiber,
beta-carotene, folate, and vitamin C (found primarily in plant-based foods)
were significantly less likely to develop cancer of the esophagus or stomach
than those who consumed low amounts of these nutrients. Those who took
vitamin C supplements were also less likely to develop certain types of
stomach cancer. In contrast, those who consumed high amounts of foods of
animal origin, including dietary cholesterol, animal protein, and vitamin
B12, were significantly more likely to develop these cancers than those who
consumed low amounts of such nutrients"
Other News:
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Pickled
Food and Risk of Gastric Cancer - A Systematic Review and Meta-Analysis of
English and Chinese Literature - Cancer Epidemiol Biomarkers Prev. 2012
Apr 12 - "We compared gastric cancer risk in pickled
vegetable/food users versus non-users (11 studies) or versus those in the
lowest reported category of use (49 studies) ... Among case-control studies,
30 showed significant increased risk and one showed significant decreased
risk. Among prospective studies, two showed a significant increased risk but
none showed a significant decreased risk. The OR (95% CI) was 1.52
(1.37-1.68) for the overall association, 1.56 (1.39-1.75) for case-control
and 1.32 (1.10-1.59) for cohort studies. The OR (95% CI) was 1.89
(1.29-2.77) in Korean, 1.86 (1.61-2.15) in Chinese, and 1.16 (1.04-1.29) in
Japanese studies, and 1.14 (0.96-1.35) in studies from other countries.
There was high heterogeneity in overall and subgroup analyses. There was
little evidence for publication bias"
-
Habitual
salt intake and risk of gastric cancer: A meta-analysis of prospective
studies - Clin Nutr. 2012 Jan 30 - "Seven
studies (10 cohorts) met the inclusion criteria (268 718 participants, 1474
events, follow-up 6-15 years). In the pooled analysis, "high" and
"moderately high" vs "low" salt intake were both associated with increased
risk of gastric cancer (RR = 1.68 [95% C.I. 1.17-2.41], p = 0.005 and
respectively 1.41 [1.03-1.93], p = 0.032), with no evidence of publication
bias"
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Stomach bacterium damages human DNA; Risk factor for gastric cancer -
Science Daily, 9/5/11
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New
technology enables quick and scarless surgery for stomach tumors -
Science Daily, 7/5/11
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Scientists Find New Way To Classify Gastric Cancers - Science Daily,
10/6/09
-
Does
Helicobacter Pylori Eradication Therapy Prevent Gastric Cancer? -
Science Daily, 9/25/09
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Predicting Patient Response To Gleevec In Gastrointestinal Stromal Tumors
- Science Daily, 4/21/09
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Thiazolidinediones inhibit REG Ialpha gene transcription in gastrointestinal
cancer cells - Biochem Biophys Res Commun. 2008 Dec 29 -
"TZDs may therefore be a candidate for novel
anti-cancer drugs for patients with gastrointestinal cancer expressing both
REG Ialpha and PPARgamma"
-
Specific H. Pylori Strains Are Associated With Precancerous Lesions -
Science Daily, 8/28/07
-
Gleevec Decreases Recurrence for Patients With Primary Gastrointestinal
Stromal Tumor - Doctor's Guide, 4/13/07
-
Sunitinib Malate (Sutent) Safe and Effective for Gastrointestinal Stromal
Tumors After Imatinib Fails - Doctor's Guide, 9/30/06
-
Processed Meats May Up Stomach Cancer - WebMD, 8/1/06
- Chemo improves stomach
cancer survival - MSNBC, 7/5/06
-
Capecitabine Plus Cisplatin Combination Effective in Patients With Advanced
Gastric Cancer - Doctor's Guide, 6/19/06
-
Survival Similar With Partial and Total Resection of Gastrointestinal
Stromal Tumors - Doctor's Guide, 3/27/06
-
Taxotere (Docetaxel) Receives U.S. FDA Approval For Use In Advanced Stomach
Cancer - Doctor's Guide, 3/23/06
-
Meat May Boost Risk of Stomach Cancer - WebMD, 2/28/06
-
Sunitinib Malate (Sutent) Provides Long-Lasting Responses in Imatinib
Mesylate-Resistant GI Stromal Tumors - Doctor's Guide, 2/2/06
-
Metastatic Gastric Cancer Patients Respond to Cetuximab Plus FOLFIRI Regimen
- Doctor's Guide, 1/30/06
-
FDA OKs New Kidney, GI Cancer Pill - WebMD, 1/26/06
-
Chemotherapy Improves Survival for Stomach and Esophageal Cancer -
Doctor's Guide, 10/19/05
-
Docetaxel Regimen Shows Significant Survival Benefit in Treatment of
Advanced Gastric Cancer - Doctor's Guide, 5/23/05
-
New
Stomach Cancer Therapy Potentially More Convenient And Better Tolerated
- Doctor's Guide, 5/19/05
-
Perioperative Chemotherapy Improves Survival in Gastric Cancer -
Doctor's Guide, 5/16/05
-
Preoperative Imatinib Prolongs Disease-Free Survival in Locally Advanced
Primary Gastrointestinal Stromal Tumors - Doctor's Guide, 3/7/05
-
Second-Line Paclitaxel and Carboplatin Show Promising Results in Advanced
Gastric Cancer - Doctor's Guide, 2/2/05
-
Targeted Therapy Plus Irinotecan and Cisplatin Appears Effective in
Metastatic Gastric Cancer - Doctor's Guide, 1/27/05
-
New Research Shows Stomach (Gastric) Cancer Originates From Bone Marrow
Derived Stem Cells - Doctor's Guide, 12/8/04
-
Tumor Shrinkage Doesn't Predict Response to Imatinib Therapy in Patients
With Gastrointestinal Stromal Tumors - Doctor's Guide, 11/4/04
-
Carboplatin, Capecitabine and Docetaxel Combination Shows Favourable Results
in Patients With Advanced Gastric or Gastroesophageal Adenocarcinoma -
Doctor's Guide, 11/2/04
- High-Dose Imatinib
Improves Survival in Gastrointestinal Stromal Tumors - Medscape, 9/24/04
-
Paclitaxel and Docetaxel Show Encouraging Results in Patients With Advanced
Gastric Cancer - Doctor's Guide, 6/23/04
-
Researchers Unveil New Clinical Treatment In The Fight Against
Gastointestinal Cancer - Science Daily, 6/10/04
-
Cisplatin Plus Gemcitabine Appears Active Against Advanced Gastric Cancer
- Doctor's Guide, 4/13/04
-
Imatinib Highlights Gastrointestinal Stromal Tumors Task Force Report -
Doctor's Guide, 3/12/04
-
Tyrosine Kinase-Targeted Therapy Effective Against Gastrointestinal Stromal
Tumours - Doctor's Guide, 3/5/04
-
Imatinib Mesylate May Be Effective in Treating Advanced Gastrointestinal
Stromal Tumours - Doctor's Guide, 2/4/04
-
Imatinib Gives Sustained Response in Gastrointestinal Stromal Cancer -
Doctor's Guide, 1/23/04
-
Chemoradiation Benefit Holds Up for Gastric Cancer - Doctor's Guide,
1/23/04
- Can Antibiotics
Lower Stomach Cancer Rates? - WebMD, 1/13/04
-
Helicobacter pylori Eradication Did Not Affect Incidence of Gastric Cancer
in a High-Risk Population, But Cut Risk in Those Without Precancerous
Lesions - Doctor's Guide, 1/13/04
-
Low Toxicity and Reasonable Efficacy With Neoadjuvant Cisplatin, 5-FU, and
Leucovorin for Locally Advanced Gastric Cancer - Doctor's Guide,
10/16/03
-
Helicobacter pylori May Help Lower Risk for Oesophageal Cancer -
Doctor's Guide, 5/23/03
- Argon Plasma
Coagulation Helpful in Intramucosal Invasive Gastric Cancer - Medscape,
3/14/03
-
Continuous Infusion Oxaliplatin/5-Fluorouracil/Leucovorin Active In Advanced
Gastric Cancer - Doctor's Guide, 3/7/03
-
Anti-p53 Antibodies And C-Reactive Protein Are Prognostic Factors In
Recurrent Oesophageal Cancer - Doctor's Guide, 2/7/03
-
Photodynamic Therapy Effective In Palliating Oesophageal Cancer Patients
- Doctor's Guide, 2/4/03
-
Digestive Cancers Linked To Occupational Asbestos Exposure - Doctor's
Guide, 12/17/02
-
Combined Oxaliplatin, Fluorouracil, Folinic Acid Effective in Advanced
Gastric Cancer - Doctor's Guide, 12/11/02
-
Capecitabine, Fluorouracil, Oxaliplatin and Cisplatin All Showing Good
Activity Against Gastric Cancer - Doctor's Guide, 11/14/02
-
Pre-Operative Cisplatin/5-Fluorouracil Provides No Increase In Squamous
Esophageal Cancer Survival - Doctor's Guide, 10/24/02
-
A Novel And Effective Regimen For Advanced Gastric Cancer - Doctor's
Guide, 10/21/02
-
Oral Capecitabine: a Promising Alternative Treatment for Advanced Gastric
Cancer - Doctor's Guide, 10/21/02
-
New Single and Combination Drugs Showing Promise in Gastric Cancer -
Doctor's Guide, 10/19/02
-
Drug Combination Has Activity In Inoperable Gastro-Oesophageal Cancers -
Doctor's Guide, 10/17/02
-
Imatinib Mesylate Shows Promising Efficacy and Safety in Advanced
Gastrointestinal Stromal Tumours - Doctor's Guide, 8/15/02
-
Imatinib Achieves Durable Results in GIST Patients, but One in Five Develops
Resistance - Doctor's Guide, 5/20/02
-
Ketoprofen May Mediate Gastric Dysrhythmias Induced By Chemoembolisation For
Liver Tumour - Doctor's Guide, 3/26/02
-
Laparoscopic Total Gastrectomies Feasible, Quick And Safe - Doctor's
Guide, 3/11/02
-
Gleevec approved for rare stomach cancer - CNN, 2/1/02
- FDA Grants Orphan Drug
Designation To Bryostatin-1, In Combination With Taxol (Paclitaxel), For
Esophageal Cancer - Doctor's Guide, 12/12/01
- Oral Anticancer Drug
Rubitecan Shows Response Rate/Disease Stabilization in Some Patients With
Advanced Stomach Cancer - Doctor's Guide, 11/12/01
- Researchers Discover How
Ulcer Bug Becomes Antibiotic-Resistant - Doctor's Guide, 4/15/98
- Stomach Cancer:
Pathologist's Findings Don't Agree - Doctor's Guide, 6/13/97
- Houseflies May Transmit
Ulcer Bug - Doctor's Guide, 5/29/97
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