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Cancer Cures > Angiostatin & Endostatin
Angiostatin, Endostatin & other anti-angiogenesis drugs
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News & Research:
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Angiogenesis Foundation
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Zyflamend
Mediates Therapeutic Induction of Autophagy to Apoptosis in Melanoma Cells -
Nutr Cancer. 2011 Jul 11 - "Zyflamend, a unique
multiherbal extract preparation, is a promising antiinflammatory agent that has
also been suggested to regulate multiple pathways in cancer progression. As
Zyflamend contains ingredients that can suppress tumor cell proliferation,
invasion, angiogenesis, and metastasis through regulation of inflammatory
pathway products, we hypothesized that this preparation might inhibit melanoma
proliferation. To test this hypothesis, we studied the effect of Zyflamend on
melanoma proliferation. Here, we present that Zyflamend inhibits melanoma growth
by regulating the autophagy-apoptosis switch. Based on the responsible molecular
mechanisms of Zyflamend, our study highlights the importance of the use of
herbal preparations for the prevention and treatment of cancer" - See
Zyflamend at Amazon.com
 .
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New
class of antiangiogenesis drugs: Natural plant compound blocks blood vessel
growth by interfering with cellular adhesion - Science Daily, 7/1/11 -
"One of two compounds identified by this process was
dehydro-alpha-lapachone (DAL), derived from Tabebuia avellanedae, a tree
native to Argentina and Brazil. Since DAL has structural similarities to
another agent with antitumor activities and did not appear to be toxic, it
was chosen for further investigation. The researchers first showed that DAL
administration interfered with blood vessel formation in zebrafish, both
during embryonic development and wound healing. They then found that it
reduced the vascular density of tumors implanted in mice and, with daily
treatment, significantly reduced tumor growth with no signs of toxicity"
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Anti-angiogenic Activity and Intracellular Distribution of
Epigallocatechin-3-gallate Analogs - Biol Pharm Bull. 2011;34(3):396-400
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"Angiogenesis, a process of construction of new blood capillaries, is
crucial for tumor progression and metastasis. Our previous studies
demonstrated that a component of green tea, epigallocatechin-3-gallate
(EGCG), suppressed angiogenesis and subsequent tumor growth. In this study,
to elucidate the detailed mechanism of the anti-angiogenic effect of EGCG
and to enhance the antiangiogenic activity of EGCG, we designed and
synthesized EGCG derivatives and examined their biological effect and
intracellular localization in human umbilical vein endothelial cells
(HUVECs). EGCG derivatives aminopentyl dideoxyEGCG and aminopentyl
dideoxygallocatechin-3-gallate (cis-APDOEGCG and trans-APDOEGCG) had an
enhanced inhibitory effect on the proliferation when used at more than 30
µM. To elucidate antiangiogenic effect of EGCG, we used a 1 µM concentration
for subsequent experiments where no effect on proliferation was observed.
These EGCG derivatives showed a stronger inhibitory effect on migration,
invasion, and tube formation by HUVECs than the non-derivatized EGCG.
Furthermore, the derivatives induced a change in the distribution of F-actin
and subsequent morphology of the HUVECs. Next, we synthesized fluorescent
TokyoGreen-conjugated EGCG derivative (EGCG-TG) and observed the
distribution in HUVECs under a confocal laser scanning microscope. Abundant
fluorescence was observed in the cells after a 3-h incubation, and was
localized in mitochondria as well as in cytoplasm. These results suggest
that EGCG was incorporated into the HUVECs, that a portion of it entered
into their mitochondria" - See
green tea extract at Amazon.com.
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DMP1
protein inhibits angiogenesis, could lead to new treatments against cancer
and other diseases - Science Daily, 1/26/11
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TED 2010: Halting Blood Vessels Key to New Cancer Treatment; Possibly
Obesity - wired.com, 2/10/10 - "What he found
was that nature has laced a large number of foods, beverages and herbs with
naturally occurring inhibitors of angiogenesis ... He and his researchers
built a simulator to test the effect different foods (see list of foods at
right) would have on blood vessels at concentrations that are available
through eating, rather than concentrated, encapsulated forms. The tests
showed that an extract of resveratrol, found in red grapes and red wine,
would inhibit abnormal angiogenesis by 60 percent. Extracts from
strawberries and soybeans had similar benefits ... They also tested four
teas — a Chinese jasmine tea, Japanese sencha, Earl Gray and a blend of the
Chinese jasmine and Japanese sencha teas. The teas varied in their
potencies. The Chinese Jasmine and Japanese sencha teas were each less
potent than the Earl Grey tea. But when they combined the two teas, the
combination was more potent than either one alone or than the Earl Grey tea.
This means there’s food synergy, Li said, and that foods likely work best in
combination to create benefits"
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Highlights from TED 2010, Wednesday: "We can eat to starve cancer" -
boingboing.net, 2/10/10 - "Angiogenesis means the
growth of blood vessels. Your body usually knows how to regulate the growth
of blood vessels, but sometimes there are defects in blood growing and
pruning. Too little angiogenesis can lead to things like wounds that won't
heal, heart attack, and other diseases. Too much angiogenesis leads to other
bad things such as blindness, arthritis. It's is a common denominator of
many diseases. It's also the "hallmark of every type of cancer." ... In
autopsies of people who died in car accidents, doctors have found
microscopic cancers in 40% of woman (breast) and 40% of men (prostate).
Something like 70% of older people have microcancers in their thyroid. But
the cancer is harmless -- "cancer without disease." If you block
angiogenesis the cancer can't grow. "It's a tipping point between harmless
cancer and deadly one.""
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New
Oral Angiogenesis Inhibitor Offers Potential Nontoxic Therapy For A Wide
Range Of Cancers - Science Daily, 6/30/08
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Blood Markers Can Help Choose Best Dose For Antiangiogenic Drugs, Study
Suggests - Science Daily, 10/29/07
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Blocking Angiogenesis Signaling From Inside Cell May Lead To Serious Health
Problems, Study Finds - Science Daily, 8/23/07
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New
Anti-angiogenesis Treatment: Combination Therapy Obliterates New Vessel
Growth In Tumors And Retinopathy - Science Daily, 1/10/07
- The Evolving Role of
Angiogenesis Inhibition in Treatment of Breast Cancer - Medscape,
11/13/06
- Pemetrexed (Alimta),
Cisplatin, Onconase, Bevacizumab (Avastin), Endostatin, and more -
mesotheliomaweb.org
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Anti-angiogenesis in Breast Cancer: an Essential Treatment Strategy -
Doctor's Guide, 2/21/06
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New Way to Block Angiogenesis Found - HealthDay, 12/16/04
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Combination Therapy May Delay Tumor Growth - Physician's Weekly, 1/26/04
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Blood Vessels Enable Tumors - HealthDay, 12/22/03
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Blocking Blood Vessels May Fight Cancer - Intelihealth, 6/2/03
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Endostatin and Tumstatin may Combat Cancer - Physician's Weekly, 4/28/03
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Starving A Tumor - Physician's Weekly, 1/13/03
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Antiangiogenesis Strategy Not Ready for Prime Time - Doctor's Guide,
12/13/02
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Naturally-Occurring Angiogenesis Inhibitor [ABT-510] Safe to Administer
Subcutaneously - Doctor's Guide, 11/25/02
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Heparanase Inhibitor May Inhibit Angiogenesis, Promote Response to Cancer
Treatment - Doctor's Guide, 11/25/02
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Dog's tale of survival opens door in cancer research - USA Today,
7/24/02 -
"The treatment is a cocktail of so-called
anti-angiogenic drugs, which have been widely researched for more than a
decade and work by starving tumors of their blood supply. Researchers say
the three-drug combination, which Haber mixed into Navy's regular dog food,
targets the cancer from many angles ...
When researchers heard that Navy was cancer-free after receiving a cocktail
of drugs already approved by the Food and Drug Administration —
Celebrex, tamoxifen (sold as
Nolvadex) and doxycycline
— the treatment became known as the Navy Protocol ... Navy's treatment,
though experimental, cost $2,000"
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Celebrated Idea For Curing Cancer Proves Hard To Translate From Mouse To Man
- Intelihealth, 5/30/02
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Researchers learning to end tumor's blood supply - USA Today, 5/16/02
- Antiostatin May Enhance
Radiation's Effects Against Cancer - Doctor's Guide, 11/8/01
- Endostatin, Angiostatin
Well Tolerated by Cancer Patients - Doctor's Guide, 10/31/01
- Angiostatin Plus Radiation
Produces Durable Partial Response In Variety Of Cancers - Doctor's
Guide, 10/31/01
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Second-Stage Trials Begin For Endostatin - Intelihealth, 7/13/01 - "The
Phase I trials found Endostatin to be safer than any cancer treatment in
history"
- Drugs Aimed at
Shutting Down Blood to Tumors Are Safe - WebMD, 5/13/01
- Endostatin Shows Promising
Anticancer Activity With Low-Toxicity Profile - Doctor's Guide, 11/10/00
- Promising New
Therapy for Advanced Breast Cancer - WebMD, 11/9/00
- New Anticancer
Drug Gets Passing Grade - WebMD, 11/9/00
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New cancer drug appears safe and promising - CNN, 11/9/00
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Early Report Shows Endostatin No Magic Bullet Against Cancer -
Intelihealth, 11/7/00
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Little Results In Cancer Drug Tests - Intelihealth, 5/11/00
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More evidence supports tumor-shrinking therapy - CNN, 9/17/99
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Tumor-Shrinking Drug To Be Tried On Humans - Intelihealth, 9/14/99
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A year after raising hopes, tumor-starving drugs still in lab - CNN,
5/11/99
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New Trials Show Cancer-shrinking Drugs' Power, Researcher Says -
Intelihealth, 4/30/99
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