There are basically two problems causing a steep decline in sales. One is that Google must have changed their algorithm and my ranking when down.  I was ranked 40,000th of all websites.  Now I'm 177,000th, which is actually an improvement of 5,000 since last month according to trustgauge.com.  The second problem is that people bookmark the products and type in the URL instead of clicking on my links.  The links on my website contain a code that gives me credit for the sale.  Also, out of all the people that read the newsletter, at least some of them must purchase from places like amazon.com yet I never get any sales through them.

I'll bet I'm losing 50% of my sales because people are still worried about their credit card number being stolen on the Internet.  I'm estimating that based on my own experience from people I know.  It seems like it's the people who are the least technical savvy that worry about it.  The don't seem to have an understanding of encryption.  If it says https:// vise http://, it’s secure.  Yeah there have been people that hacked into databases but those databases include credit card numbers whether you placed the order over the Internet, over the phone or at the store itself.  I’ve never heard of anyone that used an https:// website that had their credit card hacked via transmitting it on the Internet.  Plus, most people don’t realize that if your credit card is stolen, you are only responsible for $50 by federal.  If the loss involves your credit card number, but not the card itself, you have no liability for unauthorized use (click here for the law).  For people who are still worried about it, all the major credit card companies have a program that you can download from their website that allows you to generate a credit card number and maximum amount that can only be used once.  I used to use one for overseas pharmacies but decided it was a waste of time.

I had a credit card number stolen once and I never even used it on the Internet.  I got the card at Home Depot because it got me 10% off a washing machine.  They immediately approved the card over the phone at Home Depot and told Home Depot the card number and they put it through for the washing machine.  I received the card in the mail about a week later.  I never even used the card and put it in the bottom of a desk drawer.  Then one day I got a call from them asking if I changed $4,000 in Australia.  I said no.  They asked if I had my card and it took me about ten minutes to find it buried in the bottom of the drawer.  I told them it has never even been out of the drawer.  They said sometimes they use a random number generator and if they get one that works, they put it through.  They removed the charges and I never heard anything more about it.  I never even got a bill for it. - Ben

Recent Longevity News for the seven days ending 10/17/07.  You should consult your doctor if you are taking any medications.

N-acetyl Cysteine May Aid in Treatment of Schizophrenia - Doctor's Guide, 10/16/07 - "The study showed that NAC improves certain symptoms of schizophrenia, and therefore implicated glutathione deficiency in the pathogenesis" - See n-acetyl cysteine at Amazon.com.

Vitamin D deficiency linked to greater pain - Nutra USA, 10/15/07 - "Of these patients, 26 per cent had vitamin D inadequacy and needed almost twice the dose of morphine of the group with adequate vitamin D levels" - See vitamin D at Amazon.com.

Why Garlic Is Good for You - WebMD, 10/15/07 - "red blood cells process compounds from digested garlic and turn them into the cell messenger hydrogen sulfide (H2S), which relaxes blood vessels and increases blood flow. Therefore, eating garlic may increase our natural supply of this vital chemical and play a role in reducing the risk of heart disease" - See garlic supplements at Amazon.com.

Obesity Ups Women’s Colon Cancer Risk - WebMD, 10/15/07 - "Obesity more than doubles a woman’s risk of developing colon cancer or growths that can lead to colon cancer"

Can Statins Benefit Patients With Low LDL-Cholesterol Levels? - Physician's Weekly, 10/15/07 - "Investigators reviewed more than 6,000 patients with LDL levels of less than 60 mg/dL. After receiving a statin medication, patients with low LDL levels had better survival rates than those who did not receive the agent"

Removing Colon Polyps Cuts Death Risk - WebMD, 10'15/07 - "The researchers analyzed data on 2,602 men and women in the National Polyp Study, the landmark trial that showed that an initial colonoscopy during which the colon is cleared of precancerous polyps with regular follow-up exams significantly cut the risk of developing colon cancer by up 90% and of dying from the cancer by up to 92%"

Cholesterol Drugs May Reduce Dementia & Parkinson's Risk - Physician's Weekly Article, 10/15/07 - "there appears to be a strong reduction in dementia and Parkinson’s disease incidence attributed to the use of simvastatin, a cholesterol lowering drug. The researchers also observed a moderate reduction in incidence of these conditions with atorvastatin, another cholesterol-lowering drug"

Improving The Assessment Of Coronary Heart Disease Risk In Chinese - Science Daily, 10/12/07 - "the risk of developing coronary heart disease was more than three times as high in participants with the highest values of both apolipoprotein B and the ratio of the total cholesterol over HDL-C than patients who did not have the disease" - Natural ways to reduce apolipoprotein B:

• Broccoli compound identified for heart benefits - Nutra USA, 10/3/07 - "the indole-based compound, indole-3-carbinol, was able to reduce the secretion of apolipoprotein B-100 (apoB) by 56 per cent, and thereby confer cardiovascular benefits" - See indole-3-carbinol at Amazon.com.
• Novel Dietary Supplement [Sytrinol™] Shows Dramatic Effects in Lowering Cholesterol, LDL, and Triglycerides - Life Extension Magazine, 11/04 - "those with the highest ratios of apolipoprotein B to apolipoprotein A were at the greatest risk of dying from a heart attack ... treatment with Sytrinol™ substantially cut levels of plasma total cholesterol (-20%), LDL (-22%), apolipoprotein B (-21%), and triglycerides (-28%). Additionally, subjects in the second trial benefited from a significant 5% increase in apolipoprotein A1, an important structural protein of HDL" - See Sytrinol at Amazon.com.
• Fish Oil May Augment Atorvastatin As Treatment For Dyslipidemia In Obese, Insulin-Resistant Men - Doctor's Guide, 8/7/02 - "fish oils significantly decreased plasma levels of triglycerides and very low density lipoprotein-apoB, decreased the very low density lipoprotein-apoB secretion rate" - See TwinLab TwinEPA at iHerb and Vitacost.
• Randomized controlled trial of the effect of n–3 fatty acid supplementation on the metabolism of apolipoprotein B-100 and chylomicron remnants in men with visceral obesity1 - Am. J. of Clin. Nutr., 2/03 - "Fish oil supplementation significantly (P < 0.05) lowered plasma concentrations of triacylglycerols (-18%) and VLDL apo B (-20%) and the hepatic secretion of VLDL apo B (-29%) compared with placebo" - Doing the math, 45% of 4 grams equals 1,800 mg of EPA,  39% of 4 grams equals 1,560 mg of DHA.

Even Occasional Use Of Spray Cleaners May Cause Asthma In Adults - Science Daily, 10/12/07 - "The risk of developing asthma increased with frequency of cleaning and number of different sprays used, but on average was about thirty to fifty percent higher in people regularly exposed to cleaning sprays than in others. The researchers found that cleaning sprays, especially air fresheners, furniture cleaners and glass-cleaners, had a particularly strong effect"

Green tea may halve prostate cancer risk - Nutra USA, 10/12/07 - "Drinking five or more cups a day was associated with a 48 per cent reduction in advanced prostate cancer risk, compared to drinking less than one cup per day" - [Abstract] - See green tea extract at Amazon.com.

Statins Reduce Loss Of Function, Keeping Old Lungs Young -- Even In Smokers - Science Daily, 10/12/07 - "subjects taking statins experienced a markedly slower annual decline in lung function. In FEV1, statin users lost 10.9 ml on average, whereas nonusers lost an average of 23.9 ml each year--more than twice that of the statin group. Similarly, statin users lost an average of 14 ml a year in FVC, whereas nonusers lost an average of 36.2 ml ... the observed effect may be attributable to statins' ability to reduce inflammation and smoking-induced injury in the lung, as well as their capacity to reduce serum levels of C-reactive protein, which relates to systemic inflammation, and to protect against oxidative damage"

Choline Effective in Mouse Model of Allergic Asthma - Medscape, 10/11/07 - "Treatment with choline chloride has significant anti-inflammatory activity in a mouse model of allergic airway inflammation" - See citicholine at Amazon.com.

Baby Formula WIth Fish Oil Added May Help Infants - Science Daily, 10/11/07 - "The researchers noticed that in the piglets that were fed the control formula, fewer proteins were produced in their body over time and, at the same time, their insulin became less effective at lowering blood sugar levels. But piglets that drunk the test formula showed increased protein production and their insulin was as effective at using the proteins in the test formula for their growth as when they were born"

Statin Drugs: Heart Benefits Last Long - WebMD, 10/10/07 - "Men who got inactive placebo pills during the study had a 15.5% chance of heart attack or heart death 10 years after the study ended. Those who got five years of statin treatment had only an 11.8% chance of heart attack or heart death. They also had a lower risk of heart disease"

Do ACE inhibitors and ARBs mix well? Analysis urges caution - theheart.org, 10/10/07 - "patients receiving both an ACE inhibitor and an ARB were more likely not to comply with therapy due to side effects, which included hypotension, cough, angioedema, worsening renal function as defined by a change in serum creatinine >0.5 mg/dL, hyperkalemia as defined by serum potassium level changes >5.5 mEq/L, and symptomatic hypotension"

Women Taking Hormones Sleep Better and Have Less Vaginal Dryness - Doctor's Guide, 10/10/07 - "There is an upside for postmenopausal women taking hormone replacement therapy (HRT) -- better sleep patterns, less vaginal dryness, and fewer aches and pains"

Full-fat dairy may protect prostates from cancer - Nutra USA, 10/10/07 - "when the researchers considered intakes of specific dairy products they noted a significant 12 per cent reduction in total prostate cancer risk by increased whole milk consumption. On the other hand, low-/nonfat milk was related to 16 per cent increased risk"

Marriage And Fatherhood Linked To Lower Testosterone Levels - Science Daily, 10/10/07 - "monogamously married Ariaal men had significantly lower morning and afternoon testosterone levels compared to their single counterparts of similar age (20-39)"

Heart drug 'boosts' OAP fitness - BBC News, 10/10/07 - "Researchers discovered older people became more active when they were given an ACE inhibitor called perindopril ... After 20 weeks, the research team discovered those who had been taking the active drugs were able to take more exercise and had a better quality of life than the placebo group" - Related article:

• Keeping Seniors Independent - WebMD, 3/14/02 - "the average three-year decline in walking speed among those women who used ACE inhibitors was 10 times lower than it was in the other groups ... Researchers think several factors may explain these drugs' beneficial effect on delaying disability: ACE inhibitors increase blood flow to the muscles, reduce inflammation, and promote healthy eating habits and better nutrition by inhibiting a substance known to reduce appetite"

Low-fat Dietary Pattern May Lower Risk Of Ovarian Cancer - Science Daily, 10/9/07 - "after four years, women who decreased the amount of dietary fat they consumed were 40 percent less likely to develop ovarian cancer than women who followed normal dietary patterns. As expected, no effect was found during the first four years because preventive benefits on cancer often take many years to develop"

Women With High Or Increasing Blood Pressure Are Up To Three Times More Likely To Develop Diabetes - Science Daily, 10/9/07 - "women who have high blood pressure levels are three times more likely to develop diabetes than women with low blood pressure levels ... The authors suggest a possible mechanism for the relation between BP and diabetes may be endothelial dysfunction -- a dysfunction of the normal biochemical processes carried out by the layer of cells that line the inner surfaces of blood vessels. "It may be a precursor of both hypertension and diabetes," ... the progression of endothelial dysfunction may cause worsening of both BP and blood glucose. This is in line with the fact that both BP and blood glucose occur together as part of the metabolic syndrome"

Prostate Cancer Therapy Linked To Increased Risk Of Heart Disease Death - Science Daily, 10/9/07 - "Among men 65 years and older who had their prostates removed, the 5-year incidence of heart disease-related death was 5.5 percent for those receiving androgen deprivation, and 2 percent among those who did not. For men younger than 65 years, the rates were also increased, 3.6 percent and 1.2 percent respectively"

Omega-3 Fatty Acids and Borderline Personality Disorder - Clinical Psychiatry News, 10/07 - "Omega-3 fatty acids may be effective for reducing aggression and depression in females who suffer with moderate BPD. The results are consistent with prior findings on the efficacy of omega-3 fatty acids in the treatment of depression (Evidence-Based Psychiatric Medicine, CLINICAL PSYCHIATRY NEWS, May 2005, p. 28)" - See Mega Twin EPA at Amazon.com.

Abstracts from this week's Doctor's Guide Nutrition/Dietetics plus abstracts from my RSS feeds:

Increased calcium intake does not completely counteract the effects of increased phosphorus intake on bone: an acute dose-response study in healthy females - Br J Nutr. 2007 Oct 1;:1-8 - "When P intake was above current recommendations, increased Ca intake was beneficial for bone, as indicated by decreased S-PTH concentration and bone resorption. However, not even a high Ca intake could affect bone formation when P intake was excessive"

The effects of extended-release niacin on carotid intimal media thickness, endothelial function and inflammatory markers in patients with the metabolic syndrome - Int J Clin Pract. 2007 Nov;61(11):1942-8 - "After 52 weeks of treatment, there was a change of carotid IMT of +0.009 +/- 0.003 mm in the placebo group and -0.005 +/- 0.002 mm in the niacin group (p = 0.021 between groups). Endothelial function improved by 22% in the group treated with niacin (p < 0.001), whereas no significant changes were seen in the placebo group. High sensitivity C-reactive protein decreased by 20% in the group treated with niacin for 52 weeks (p = 0.013). Niacin increased HDL-C (p < 0.001) and decreased low-density lipoprotein cholesterol and triglycerides (p < 0.001) significantly, and there were no adverse effects on fasting glucose levels after 52 weeks of treatment" - See niacin at Amazon.com or niacin at Amazon.com.  Yeah but the problem with extended-release:

• A comparison of the efficacy and toxic effects of sustained- vs immediate-release niacin in hypercholesterolemic patients - JAMA. 1994 Mar 2;271(9):672-7 - "None of the patients taking IR niacin developed hepatotoxic effects, while 12 (52%) of the 23 patients taking SR niacin did. CONCLUSION--The SR form of niacin is hepatotoxic and should be restricted from use. The IR niacin is preferred for the management of hypercholesterolemia but can also cause significant adverse effects and should be given only to patients who can be carefully monitored by experienced health professionals."

Vitamin D therapy in clinical practice. One dose does not fit all - Int J Clin Pract. 2007 Nov;61(11):1894-9 - "Vitamin D therapy with conventional treatment improves serum levels of 25 hydroxy vitamin D but still leaves some patients with significant insufficiency and therefore the same dose of vitamin D is not appropriate for all"

A diet enriched in eicosapentanoic acid, gamma-linolenic acid and antioxidants in the prevention of new pressure ulcer formation in critically ill patients with acute lung injury: A randomized, prospective, controlled study - Clin Nutr. 2007 Oct 12 - "A diet enriched with EPA, GLA and vitamins A, C and E is associated with a significantly lower occurrence of new pressure ulcers in critically ill patients with acute lung injury"

Genistein and daidzein prevent diabetes onset by elevating insulin level and altering hepatic gluconeogenic and lipogenic enzyme activities in non-obese diabetic (NOD) mice - Diabetes Metab Res Rev. 2007 Oct 11 - "Blood glucose levels of genistein and daidzein groups were 40 and 36% of control value at the end of study (9th week). The genistein and daidzein supplements increased insulin/glucagon ratio and C-peptide level with preservation of insulin staining beta-cell of pancreas in the NOD mice ... The supplementation of genistein and daidzein are seemingly helpful for preventing IDDM onset"

Green Tea Consumption and Prostate Cancer Risk in Japanese Men: A Prospective Study - Am J Epidemiol. 2007 Sep 29 - "The multivariate relative risk was 0.52 (95% confidence interval: 0.28, 0.96) for men drinking 5 or more cups/day compared with less than 1 cup/day (p(trend) = 0.01). Green tea may be associated with a decreased risk of advanced prostate cancer" - See green tea extract at Amazon.com.

Is vitamin D deficiency to blame for the asthma epidemic? - J Allergy Clin Immunol. 2007 Oct 3 - "higher vitamin D intake by pregnant mothers reduces asthma risk by as much as 40% in children 3 to 5 years old" - See vitamin D at Amazon.com.

Clinical trial: multispecies probiotic supplementation alleviates the symptoms of IBS and stabilises intestinal microbiota - Aliment Pharmacol Ther. 2007 Oct 6 - "The composite IBS score had at five months decreased 14 points (95% CI: -19 to -9) from baseline with the multispecies probiotic versus 3 points (95% CI: -8 to 1) with placebo (p=0.0083). Especially distension and abdominal pain were affected" - See probiotics at Amazon.com.

Which antidepressants have demonstrated superior efficacy? A review of the evidence - Int Clin Psychopharmacol. 2007 Nov;22(6):323-329 - "Criteria were defined to judge the strength of evidence. Two pivotal studies in moderate-to-severe major depressive disorder that demonstrate superiority on the primary efficacy measure, or alternatively one pivotal study supported by consistent results from meta-analyses, was considered to constitute evidence for definite superiority. Three antidepressants met these criteria: clomipramine, venlafaxine, and escitalopram. Three antidepressants were found to have probable superiority: milnacipran, duloxetine, and mirtazapine. Only escitalopram was found to have definite superiority in the treatment of severe depression; probable superiority was identified for venlafaxine and possible superiority for milnacipran and clomipra"

Proanthocyanidin from grape seeds inactivates the PI3-kinase/PKB pathway and induces apoptosis in a colon cancer cell line - Cancer Lett. 2007 Oct 6 - "grape seed proanthocyanidin extract (GSPE) ... GSPE (10-100mug/ml) significantly inhibited cell viability and increased apoptosis in CaCo2 cells, but did not alter viability in the normal colon cell line (NCM460). The increased apoptosis observed in GSPE-treated CaCo2 cells correlated with an attenuation of PI3-kinase (p110 and p85 subunits) and decreased PKB Ser(473) phosphorylation. GSPE might thus exert its beneficial effects by means of increased apoptosis and suppression of the important PI3-kinase survival-related pathway" - See grape seed extract at Amazon.com.

Adverse Effects of Combination Angiotensin II Receptor Blockers Plus Angiotensin-Converting Enzyme Inhibitors for Left Ventricular Dysfunction: A Quantitative Review of Data From Randomized Clinical Trials - Arch Intern Med. 2007 Oct 8;167(18):1930-6 - "there were significant increases in worsening renal function (RR, 2.17 [95% CI, 1.59-2.97] and RR, 1.61 [95% CI, 1.31-1.98], respectively), hyperkalemia (RR, 4.87 [95% CI, 2.39-9.94] and RR, 1.33 [95% CI, 0.90-1.98], respectively"

Health Focus (Glycemic Index/Glycemic Load):

General Glycemic Index/Glycemic Load Information:

• The Glycemic Index - Dr. Murray's Newsletter, 4/3/03 - "The GL calculated by multiplying the amount of carbohydrate in a serving of food multiplied by that food's GI (as compared to glucose) as a decimal"
• GlycemicIndex.com
• Glycemic Index Table - Nutrition Science News, 4/00
• Books on glycemic index - Amazon.com

Glycemic Index/Glycemic Load News & Research:

• Food for Thought: Fattening Carbs—Some Promote Obesity and Worse - Science News, 9/29/07 - "In the study, mice that chowed down on a type of rapidly digestible starch didn't gain any more weight than did animals eating a starch that digests slowly. But the first group did accumulate lots of excess fat"
• Quick-burning Carbs May Cause Fatty Liver: Low-glycemic Diet Protected Mice - Science Daily, 9/21/07 - "After six months, the mice weighed the same. However, mice on the low-glycemic index diet were lean, with normal amounts of fat in throughout their bodies. Mice on the high-glycemic index diet had twice the normal amount of fat in their bodies, blood and livers"
• Starchy diet 'may damage liver' - BBC News, 9/21/07 - ""High-glycaemic" foods - rapidly digested by the body - could be causing "fatty liver", increasing the risk of serious illness ... After six months on the diet, the mice weighed the same, but those on the high GI diet had twice the normal amount of fat in their bodies, blood and livers"
• Sugary Drinks, Not Fruit Juice, May Be Linked To Insulin - Science Daily, 9/5/07 - "Study participants who consumed two or more sugar-sweetened beverages per day had significantly higher fasting blood levels of insulin as compared to participants who did not report consuming any such beverages, regardless of age, sex, weight, smoking status, or other dietary habits ... Higher fasting levels of insulin mean these study participants are more at risk for developing Type 2 diabetes ... consumption of 100 percent fruit juice was not significantly related to any of our measures of insulin resistance"
• Right Breakfast Bread Keeps Blood Sugar In Check All Day - Science Daily, 9/5/07 - "It is known that a carbohydrate-rich breakfast with low GI can moderate increases in blood sugar after lunch. But my results show that low GI in combination with the right amount of so-called indigestible carbohydrates, that is, dietary fiber and resistant starch, can keep the blood-sugar level low for up to ten hours, which means until after dinner ... people with great fluctuations in their levels of blood sugar run a greater risk of having a generally lower cognitive ability"
• Study links low-GI kids' breakfast to less calories - Nutra USA, 9/4/07 - "The children ate on average 61 kcal less over the days they were given the low-GI breakfast, compared with the days when they ate a high-GI breakfast"
• Dietary Glycemic Index Tied to Risk of Age-Related Macular Degeneration - Medscape, 7/30/07
• High-Sugar Foods May Affect Eyesight - WebMD, 7/13/07 - "People with the diets highest on the glycemic index were the most likely to have advanced AMD in at least one eye"
• Link Between Carbohydrate Quality And Vision Loss Is Strengthened By New Data - Science Daily, 7/11/07 - "the risk for AMD may be diminished by improving dietary carbohydrate quality, as defined by dietary glycemic index. This may be achieved by relatively simple dietary alterations, such as replacing white bread with whole grain bread"
• Low-Glycemic Load Diet May Work for Dieters With Certain Insulin Response Patterns - Science Daily, 5/16/07
• Biology Dictates Diet Success - WebMD, 5/15/07 - "The low-glycemic-load diet was effective for a lot of the individuals who were high-insulin secretors and who previously had challenges losing weight and keeping it off"
• Low-Glycemic-Index Diet Slows AMD Progression - Medscape, 5/8/07 - "age-related macular degeneration (AMD) ... consumption of highly refined carbohydrates can lead to up to a 17% increased risk of AMD progression"
• Low Glycaemic Index Diet Improves Insulin Sensitivity in Overweight Women - Doctor's Guide, 4/25/07
• Study Examines Calorie Restriction and Glycemic Load - Doctor's Guide, 4/10/07 - "Unlike several other long-term studies, which have reported greater weight loss with low GL diets at six months but no differences by 12 months, our data show no significant short-term or long-term differences"
• Low glycemic diet may help stay slim - MSNBC, 10/27/06 - "normal-weight women who ate a diet with a relatively high glycemic index gained more weight, more fat, and more padding around the middle over a six-year period than women who ate a low glycemic index diet"
• High Bread Consumption Linked To Higher Risk Of Most Common Kidney Cancer - Science Daily, 10/20/06 - "A significant direct association was observed for bread consumption (OR=1.94) for the highest compared to the lowest quintile of intake ... By contrast, decreasing risk was associated with increasing intake of poultry, processed meat, and all vegetables, both raw and cooked ... The association between elevated cereal intake (bread, pasta and rice) "may be due to the high glycemic index of these foods"
• Low Glycemic Index Diet Best For Weight Loss And Cardiovascular Health - Science Daily, 7/26/06
• High Carb, Low Glycemic Index Diet Best to Reduce CV Risk - Medscape, 7/25/06
• What Is the Glycemic Index? - Dr. Weil, 6/23/06
• Loss of Central Vision with Age May Be Linked to Quality of Dietary Carbohydrates - Doctor's Guide, 6/6/06 - "Women who consumed diets with a relatively high dietary glycemic index had greater risk of developing signs of early age-related macular degeneration when compared with women who consumed diets with a lower dietary glycemic index"
• High Glycemic Index Diet May Increase Risk of Developing AMD - Medscape, 4/18/06 - "The age-adjusted model showed more than a 2-fold increase in risk for ARM for the third tertile of dietary GI"
• The science of blood sugar - .ffnmag.com, 2/06
• Glycemic Index and Glycemic Load of Popular Diets - Medscape, 1/24/06 - "The impact of GI and GL on efforts to prevent and treat obesity remains to be determined"
• Carbohydrate-rich diets may improve insulin control - Nutra USA, 1/11/06 - "Although an increasing body of evidence would suggest merit in adopting high-carbohydrate, low-GI diets, the charge that high-GI diets result in insulin resistance is unproven on the basis of current experimental data"
• Insulin Resistance Atherosclerosis Study - Diabetes Care. 2005;28(12):2832-2838 - "our results demonstrate a remarkable degree of consistency in finding a lack of association of glycemic index, glycemic load, and carbohydrate intake with measures of insulin sensitivity, insulin secretion, and adiposity"
• The Biggest Loser: Weight Loss May Depend On Where Calories Come From - Science Daily, 12/8/05
• Low-Glycemic Load Diet Facilitates Weight Loss in Overweight Adults with High Insulin Secretion - Doctor's Guide, 12/7/05 - "The regulation of body weight is, at least in part, influenced by how much insulin a person secretes in response to a load of glucose, as well as by how sensitive that person is to insulin's glucose-lowering effects"
• Reducing GI does not boost effects of low-calorie diet - Nutra USA, 10/26/05 - "although the new trial confirmed the benefit of lowering glycaemic index on insulin sensitivity, it did not impact the subjects' weight"
• High Glycemic Index or High Carbohydrate Diet May Not Increase Risk of Insulin Resistance - Medscape, 6/6/05 - "Habitual intake of diets with a high glycemic index and high glycemic load or diets with a high content of total carbohydrate including simple sugars was not associated with the probability of having insulin resistance ... intake of dietary fiber was inversely associated with the probability of having insulin resistance"
• Weight Watchers Diet Produces Same Results With or Without Emphasis on Low-Glycaemic Index - Doctor's Guide, 6/6/05 - "both groups lost an average of 5% of their initial body weight ... However, those who followed the low-glycemic diet had better satiety and less hunger and craving, the key problems that are the downfall of many dieters" - This article doesn't mention fat loss.  You can have the same loss in pounds yet have different percentages of lean muscle/fat loss as in the next article.
• Clearing up the confusion over carbs - MSNBC, 6/3/05 - "Both groups lost weight, and there was no difference in their weight loss or calorie intake. It should be noted, however, that the women who ate low GI foods lost more than twice as much body fat as women eating mainly high GI foods"
• Low-g could reduce cardiovascular risk in obese - Nutra USA, 5/17/05
• Low-Glycemic Load Diet May Improve Ability to Stay on Diet Longer - Doctor's Guide, 11/24/04
• Healthy Carbs, Fats for Weight Loss - WebMD, 11/23/04 - "eating a so-called low-glycemic diet may overcome the body's natural tendency to slow metabolism when calories are restricted. A low-glycemic diet emphasizes healthy fats and carbohydrates"
• The glycaemic index: a route to better health? - Functional Foods & Nutraceuticals, 10/04
• Sick of Low-Carb Diets? Try Low-GI - WebMD, 8/26/04 - "The animals on the high-GI diet were gaining more weight with same amount of food, and we had to cut their food back increasingly over time to keep them at the same weight ... But what was really interesting to us was that even though they maintained the same weight because they got less food, the high-GI group in both rats and mice doubled their body fat and had a reduction ... in muscle mass, which is exactly what you don't want"
• Counting Carbs? - Dr. Weil, 8/17/04
• High-Glycemic Foods Linked to Colon Cancer - WebMD, 2/3/04 - "the future risk of colorectal cancers is nearly three times higher in women who eat the most high glycemic-load foods compared with those who eat lesser amounts"
• Sugary Breakfast Boosts Lunchtime Hunger - WebMD, 11/3/03 - "A new study provides evidence favoring foods with low-glycemic indexes (GI) such as whole-grain breakfast cereals including oatmeal, bran cereal, and muesli (a Swedish tradition). It shows that foods with low GI's can keep us feeling full and that these foods may have an important role in weight loss and obesity management"
• Focusing on Fiber? - Dr. Weil, 9/22/03 - "If you’ve tried but failed to lower your cholesterol with a high-carbohydrate, low-fat diet, the problem may have been the carbohydrates you were eating. Refined carbohydrates (those that are high on the glycemic index, a system of ranking foods by their effect on blood sugar) can cause rapid increases in blood sugar, prompting the pancreas to release insulin, which in turn signals the liver to pump more triglycerides into the bloodstream"
• Dietary Experts Debate Carbohydrates - Intelihealth, 9/2/03 - "Blood sugar levels may shoot twice as high after a high-GI meal as after a low one, and that unleashes metabolic havoc: The body responds with a surge of insulin, which prompts it to quickly store the sugar in muscle and fat cells. The high sugar also inhibits another hormone, glucagon, which ordinarily tells the body to burn its stored fuel ... Blood sugar plunges. So much is stored so fast that within two or three hours, levels may be lower than they were before the meal. Suddenly, the body needs more fuel. But because glucagon is still in short supply, the body does not tap into its fat supply for energy. The inevitable result? Hunger ... After one year, the low-GI volunteers had dropped seven pounds of pure fat. The others had put on four"
• Glycemic Index: New Way to Count Carbs? - WebMD, 8/20/03 - "Foods with a high glycemic index (and therefore a higher number) cause a sudden and drastic jump in blood sugar levels. Low-glycemic foods are more easily absorbed in the body and raise blood sugar more gradually ... The American Journal of Clinical Nutrition lists any food under 55 as a low-glycemic food and any food more than 70 as high glycemic"
• New Diet Approach May Fight Child Obesity - WebMD, 8/12/03 - "a reduced-glycemic-load diet that emphasizes foods with a low to moderate glycemic index and allows children to eat until they're full was more effective than a traditional low-fat, calorie-restricted diet in helping obese children shed pounds and slow the progression of insulin resistance, a risk factor for diabetes ... Complex carbohydrates, such as whole-grain bread and cereals, brown rice, and vegetables, are foods with a low to moderate glycemic index"
• Ways Of Reducing Glycaemic Load Vary In Effects - Doctor's Guide, 3/10/03
• Cardiovascular Risk Factors Affected By Diet -  Doctor's Guide, 2/27/03 - "Although patients were advised to maintain an identical energy intake with the different diets, there was significant weight loss on the low glycaemic index diet compared with weight gain on the high sucrose diet"
• What is hyperinsulimia? How is it controlled? What are the tests? What is Glucophage? - Dr. Weil, 9/3/02 - "People with the genetic tendency to develop metabolic syndrome can avoid it by getting regular exercise and by minimizing consumption of high-glycemic index carbohydrate foods"
• Cracking the Fat Riddle - Time Magazine, 9/2/02 - "the food pyramid is due for an overhaul in 2003—although no one is yet willing to give any details. If Harvard's Willett has his way, the pyramid will make a greater distinction between the types of fats and carbs we should and shouldn't eat. Willett, unlike the USDA, does not lump most carbohydrates at the pyramid's base or all fats at the pyramid's eat-sparingly pinnacle. In fact, Willett places good fats—those from vegetables and fish—at the base and good carbohydrates—from whole-grain versions of bread and pasta—side by side at the base. Carbohydrates with a high glycemic load join saturated fats at the top"
• Low Glycaemic Index Diet Might Prevent Metabolic Diseases - Doctor's Guide, 5/16/02
• Glycemic Index Helpful in Food Selection - Medscape, 5/8/02 - "11 healthy men were randomly allocated to 5 weeks of a low- or high-glycemic index (LGI or HGI) diet separated by a 5-week washout period in a crossover design. Compared with the HGI diet, the LGI diet resulted in lower postprandial plasma glucose and insulin profiles and areas under the curve, lower plasma triacylglycerol excursion after lunch, decreased total fat mass by approximately 700 g, and a tendency to increase lean body mass without changing body weight. Decreased leptin, lipoprotein lipase, and hormone-sensitive lipase mRNA quantities in the subcutaneous abdominal adipose tissue accompanied decreased fat mass"
• Glycemic Index, Glycemic Load And Certain Foods Linked To Breast Cancer - Doctor's Guide, 12/17/01 - "Consumption of foods that are associated with a high glycemic index, such as white bread, increased breast cancer risk: odds ratio 1.3. In contrast, pasta, which is associated with a medium glycemic index, did not seem to influence breast cancer risk: odds ratio 1.0 ... glycemic index and glycemic load show "moderate, direct associations" with breast cancer risk. This suggests that hyperinsulinemia and insulin resistance might contribute to the risk of developing breast cancer"
• Diet Trial Finds Marked Reduction In Energy Intake - Doctor's Guide, 12/12/01
• Evidence Builds for Use of Glycemic Index to Control Diabetes - WebMD, 7/19/01
• Experts Take On the 'Hunger Index' - WebMD, 8/3/00
• Cancer's Sweet Tooth - Nutrition Science News, 4/00
• Carbohydrates and Glycemic Index - Ask the Dietician

Glycemic Index/Glycemic Load Abstracts:

• Glycaemic index, glycaemic load and ovarian cancer risk: a prospective cohort study - Public Health Nutr. 2007 Oct;10(10):1076-81 - "Glyacemic index (GI) and glycaemic load (GL) .. GI and total carbohydrate and sugar intakes were not associated with ovarian cancer risk in the total cohort. GL was positively associated with a 72% increase in risk of ovarian cancer"
• Beneficial effects of a 5-week low-glycaemic index regimen on weight control and cardiovascular risk factors in overweight non-diabetic subjects - Br J Nutr. 2007 Jul 9;:1-11 - "Mean body weight decrease was significant in the LGI group ( - 1.1 (sEM 0.3) kg, P = 0.004) and was significantly greater than in the HGI group ( - 0.3 (sEM 0.2) kg, P = 0.04 between groups). Hunger sensation scales showed a trend towards a decrease in hunger sensation before lunch and dinner in the LGI group when compared with the HGI group (P = 0.09). No significant increase in insulin sensitivity was noticed. The LGI diet also decreased total cholesterol by 9.6 % (P < 0.001), LDL-cholesterol by 8.6 % (P = 0.01) and both LDL-:HDL-cholesterol ratio (10.1 %, P = 0.003) and total:HDL-cholesterol ratio (8.5 %, P = 0.001) while no significant changes were observed in the HGI group"
• Association between dietary glycemic index and age-related macular degeneration in nondiabetic participants in the Age-Related Eye Disease Study - Am J Clin Nutr. 2007 Jul;86(1):180-8 - "Compared with eyes in the first quintile of dGI, eyes in the fourth and fifth quintiles had a significantly or suggestively higher risk of large drusen, geographic atrophy, and neovascularization. The multivariate-adjusted odds ratios (95% CIs) for the highest quintile were 1.42 (1.09, 1.84), 1.78 (0.81, 3.90), and 1.41 (0.95, 2.08), respectively, of which only the odds ratio for large drusen was significant. A significant positive relation between dGI and severity of AMD was also noted (P for trend < 0.001). There was a 49% increase in the risk of advanced AMD (geographic atrophy plus neovascularization) for persons with a dGI higher than the sex median"
• High dietary glycemic load and glycemic index increase risk of cardiovascular disease among middle-aged women: a population-based follow-up study - J Am Coll Cardiol. 2007 Jul 3;50(1):14-21 - "Dietary glycemic load (mean = 100; SD = 17) was associated with increased risk of CVD, adjusted for CVD risk factors and dietary variables, with a hazard ratio (HR) for the highest against lowest quartile of 1.47 (95% confidence interval [CI] 1.04 to 2.09; p(trend) = 0.03). Similar results were observed for dietary glycemic index with a corresponding HR of 1.33"
• Dietary glycemic index, dietary glycemic load, and cardiovascular disease in middle-aged and older Swedish men - Am J Clin Nutr. 2007 Jun;85(6):1521-1526 - "glycemic index (GI) and dietary glycemic load (GL) ... Dietary GI and dietary GL were not associated with ischemic cardiovascular disease or mortality, but dietary GL was associated with a greater risk of hemorrhagic stroke"
• The effect of a 12-week low glycaemic index diet on heart disease risk factors and 24 h glycaemic response in healthy middle-aged volunteers at risk of heart disease: a pilot study - Eur J Clin Nutr. 2007 Feb 21 - "only the low GI group lost weight ... This pilot study provides some evidence that consuming a low GI diet in addition to weight loss and healthy eating may reduce cardiovascular risk"
• Low-carbohydrate-diet score and the risk of coronary heart disease in women - N Engl J Med. 2006 Nov 9;355(19):1991-2002 - "During 20 years of follow-up, we documented 1994 new cases of coronary heart disease. After multivariate adjustment, the relative risk of coronary heart disease comparing highest and lowest deciles of the low-carbohydrate-diet score was 0.94 (95% confidence interval [CI], 0.76 to 1.18; P for trend=0.19). The relative risk comparing highest and lowest deciles of a low-carbohydrate-diet score on the basis of the percentage of energy from carbohydrate, animal protein, and animal fat was 0.94 (95% CI, 0.74 to 1.19; P for trend=0.52), whereas the relative risk on the basis of the percentage of energy from intake of carbohydrates, vegetable protein, and vegetable fat was 0.70 (95% CI, 0.56 to 0.88; P for trend=0.002). A higher glycemic load was strongly associated with an increased risk of coronary heart disease (relative risk comparing highest and lowest deciles, 1.90"
• Relations of glycemic index and glycemic load with plasma oxidative stress markers - Am J Clin Nutr. 2006 Jul;84(1):70-6 - "Chronic consumption of high-GI foods may lead to chronically high oxidative stress. A low-GI diet, not a low-carbohydrate diet, appears to be beneficial in reducing oxidative stress"
• Glycaemic index, glycaemic load and risk of endometrial cancer: a prospective cohort study - Public Health Nutr. 2005 Oct;8(7):912-9 - "Our data suggest that diets with high glycaemic index or high glycaemic load may be associated with endometrial cancer risk overall, and particularly among obese women, premenopausal women and postmenopausal women who use hormone replacement therapy"
• Dietary Glycemic Index, Glycemic Load, Fiber, Simple Sugars, and Insulin Resistance: The Inter99 study - Diabetes Care. 2005 Jun;28(6):1397-1403 - "Habitual intake of diets with a high glycemic index and high glycemic load or diets with a high content of total carbohydrate including simple sugars was not associated with the probability of having insulin resistance. Furthermore, intake of dietary fiber was inversely associated with the probability of having insulin resistance"
• Low-fat, high-carbohydrate (low-glycaemic index) diet induces weight loss and preserves lean body mass in obese healthy subjects: results of a 24-week study - Diabetes Obes Metab. 2005 May;7(3):290-3 - "after 24 weeks the average weight loss was 8.9 kg (98.6 vs. 89.7 kg; p </= 0.0001). There was a significant 15% decrease in fat mass (42.5 vs. 36.4 kg; p </= 0.0001) and a decrease in lean body mass of 5%"
• The beneficial effect of a diet with low glycaemic index on 24 h glucose profiles in healthy young people as assessed by continuous glucose monitoring - Br J Nutr. 2005 Feb;93(2):179-82 - "The present study provides important data on how a simple adjustment to the diet can improve glucose profiles that, if sustained in the long term, would be predicted from epidemiological studies to have a favourable influence on CVD"
• Effects of a low-glycemic load diet on resting energy expenditure and heart disease risk factors during weight loss - JAMA. 2004 Nov 24;292(20):2482-90 - "Reduction in glycemic load may aid in the prevention or treatment of obesity, cardiovascular disease, and diabetes mellitus"
• Glycemic index and dietary fiber and the risk of type 2 diabetes - Diabetes Care. 2004 Nov;27(11):2701-6 - "Reducing dietary GI while maintaining a high carbohydrate intake may reduce the risk of type 2 diabetes. One way to achieve this would be to substitute white bread with low-GI breads"
• Meta-analysis of the health effects of using the glycaemic index in meal-planning - Br J Nutr. 2004 Sep;92(3):367-81 - "Results of the present meta-analysis support the use of the GI as a scientifically based tool to enable selection of carbohydrate-containing foods to reduce total cholesterol and to improve overall metabolic control of diabetes"
• Glycemic index and glycemic load in endometrial cancer - Int J Cancer. 2003 Jun 20;105(3):404-7 - "Our study supports the hypothesis of a direct association between GI and endometrial cancer risk"

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