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Home > Health Conditions > Endometrial Cancer

Endometrial Cancer

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  • Indole-3-Carbinol Inhibits the Growth of Endometriotic Lesions by Suppression of Microvascular Network Formation - Nutrients 2022 Nov 21 - "I3C inhibited the vascularization and growth of endometriotic lesions without inducing anti-angiogenic and anti-proliferative side effects on reproductive organs. This was associated with a significantly reduced number of proliferating stromal and endothelial cells and a lower expression of the pro-angiogenic signaling molecules vascular endothelial growth factor receptor-2 (VEGFR2), phosphoinositide 3-kinase (PI3K) and phosphorylated extracellular signal-regulated kinase (pERK) within I3C-treated lesions when compared to controls. These findings indicate that I3C effectively inhibits endometriotic lesion formation in mice. Thus, further studies should clarify whether I3C may be also beneficial for the prevention and therapy of the human disease" - See indole-3-carbinol at Amazon.com.
  • Simvastatin Inhibits Endometrial Cancer Malignant Behaviors by Suppressing RAS/Mitogen-Activated Protein Kinase (MAPK) Pathway-Mediated Reactive Oxygen Species (ROS) and Ferroptosis - Evid Based Complement Alternat Med 2022 Oct 14 - "All in all, simvastatin reduces the RAS/MAPK signaling pathway to inhibit Ishikawa cell proliferation, colony formation, and invasion, and promote cell oxidation and ferroptosis. This paper demonstrates the potential of simvastatin as a new anticancer drug for EC"
  • Coffee consumption and risk of endometrial cancer: a pooled analysis of individual participant data in the Epidemiology of Endometrial Cancer Consortium (E2C2) - Am J Clin Nutr 2022 Aug 30 - "Coffee drinkers had a lower risk of EC compared to non-coffee drinkers (multi-adjusted OR = 0.87, 95% CI = 0.79,0.95). There was a dose-response relationship between higher coffee consumption and lower risk of EC: compared to non-coffee drinkers, the adjusted pooled ORs for those who drank 1, 2-3 and more than 4 cups/day were 0.90 (95% CI = 0.82,1.00), 0.86 (95% CI = 0.78,0.95), and 0.76 (95% CI = 0.66,0.87), respectively (p for trend < 0.001). The inverse association between coffee consumption and EC risk was stronger in participants with body mass index (BMI) over 25 kg/m2"
  • Coffee Drinking and the Risk of Endometrial Cancer: An Updated Meta-Analysis of Observational Studies - Nutr Cancer. 2018 May-Jun;70(4):513-528 - "The summary RR for highest compared with lowest coffee intake was 0.74"
  • The Prescription Pattern of Chinese Herbal Products Containing Ginseng among Tamoxifen-Treated Female Breast Cancer Survivors in Taiwan: A Population-Based Study - Evid Based Complement Alternat Med. 2015 - "Chinese herbal products (CHPs) ... tamoxifen (TMX) ... The HR for the development of endometrial cancer among breast cancer survivors who had ever taken Ginseng after TXM treatment was significantly decreased compared to those who never used CHP" - See ginseng at Amazon.com.
  • Long-chain ω-3 fatty acid intake and endometrial cancer risk in the Women's Health Initiative - Am J Clin Nutr. 2015 Mar 4 - "In women with body mass index (BMI; in kg/m(2)) <25, those in the upper compared with lowest quintiles of total LCω-3PUFA intake (sum of eicosapentaenoic, docosapentaenoic, and docosahexaenoic acids) had significantly reduced endometrial cancer risk (HR: 0.59; 95% CI: 0.40, 0.82; P-trend = 0.001), whereas there was little evidence of an association in overweight or obese women" - Note:  The RSS version contained significantly more text than the link that went to the NIH page.  I think they must have changed the abstract after it was fed to the RSS feed.  See fish oil supplements at Amazon.com.
  • Association of Dietary Glycemic Index and Glycemic Load with Endometrial Cancer Risk Among Chinese Women - Nutr Cancer. 2014 Dec 12:1-9 - "Multivariable-adjusted odds ratios (ORs) for increasing quartiles of intake were 1.0, 1.3, 1.4, and 2.2 [95% confidence interval (CI): 1.2-4.0] for dietary GL (Ptrend = 0.02) and 1.0, 1.2, 1.4, and 1.4 (95% CI: 1.0-2.0) for dietary GI (Ptrend = 0.02). High intake of staples, especially rice, was positively associated with endometrial cancer"
  • Inhibition of endometrial cancer by n-3 polyunsaturated fatty acids (PUFAs) in preclinical models - Cancer Prev Res (Phila). 2014 May 27 - "Taken together, our findings provide comprehensive preclinical evidences that n-3 PUFAs efficiently prevent endometrial cancer and establish mTORC1/2 as a target of n-3 PUFAs" - See fish oil supplements at Amazon.com.
  • The prognostic value of metformin for cancer patients with concurrent diabetes- a systematic review and meta-analysis - Diabetes Obes Metab. 2014 Jan 27 - "A literature search was performed using the PubMed, EMbase and SciVerse Scopus databases ... metformin was associated with lower risk of all-cause mortality in cancer patients with concurrent diabetes, particularly for breast (pooled relative risk (RR) 0.70, 95% CI 0.55, 0.88; P=0.003), colorectal (RR 0.70, 95% CI 0.59, 0.84; P<0.001), ovarian (RR 0.44, 95% CI 0.30, 0.64; P<0.001) and endometrial cancer (RR 0.49, 95% CI 0.32, 0.73; P=0.001). In addition, metformin was associated with lower risks of cancer-specific mortality" - See metformin at The Antiaging Store.
  • Food Intake and the Risk of Endometrial Endometrioid Adenocarcinoma in Japanese Women - Nutr Cancer. 2013 Sep 20 - "The present study examined the association between food intake and endometrial cancer restricted to endometrial endometrioid adenocarcinoma (EEA) using a case-control study in Japanese women ... completed a questionnaire ... the higher intakes of vegetables [odds ratio (OR) = 0.47, 95% confidence interval (CI) = 0.26-0.83], peanuts (OR = 0.48, CI = 0.27-0.86), fish (OR = 0.52, CI = 0.29-0.93), boiled egg (OR = 0.24, CI = 0.33-0.92), instant noodles (OR = 1.94, CI = 1.12-3.34), instant food items (OR = 2.21, CI = 1.31-3.74), and deep-fried foods (OR = 2.87, CI = 1.58-5.21) were associated with a risk for EEA"
  • Drop the cookie: Sweet, starchy foods 'probably' cause women’s cancer - today.com, 9/10/13 - "AICR now estimates that most cases of endometrial cancer (59 percent, or about 29,500 every year) could be prevented in the U.S. if women were active for at least 30 minutes a day and maintained a healthy body weight ... Estrogen is one known cause and women who take hormones, as in hormone replacement therapy, are usually given a form of progesterone, also, to protect against endometrial cancer ... Women who are obese have two to three times the rate of endometrial cancer .. There were eight studies showing coffee lowers the risk ... The team also found at least six studies that indicate glycemic load affects the risk ... The bottom line is you want to eat whole grains instead of refined grains and sugary foods"
  • Aspirin, nonsteroidal anti-inflammatory drugs, paracetamol, and risk of endometrial cancer: A case control study, systematic review, and meta-analysis - Int J Cancer. 2012 Jul 9 - "We analysed data from the Australian National Endometrial Cancer Study (ANECS), a population-based case-control study ... For the meta-analysis risk estimates were pooled using a random-effects model. In our case-control study women who had ever used aspirin in the last 5 years had significantly lower risk of endometrial cancer OR=0.78 (95%CI: 0.63-0.97). There was a significant inverse dose-response (P-trend <0.001) such that women who reported using =2 aspirin/week had almost half the risk OR=0.54 (0.38-0.78). No significant associations were observed between use of half-aspirin/day, non-aspirin NSAIDs or paracetamol and endometrial cancer risk. The results were similar when examined by cancer subtype. Nine studies were included in the meta-analysis. The overall pooled risk estimate for any vs. no use of aspirin was 0.87 (0.79-0.96) with no evidence of heterogeneity. The pooled risk estimate for obese women (BMI=30 kg/m(2) ) was 0.72 (0.58-0.90) but there was no association for non-obese women. Overall these results suggest that aspirin may reduce the risk of endometrial cancer, particularly among obese women"
  • Insulin resistance: A significant risk factor of endometrial cancer - Gynecol Oncol. 2012 Mar 23 - "Risk factors of insulin resistance, such as the inflammatory mediators, adipokines adiponectin, leptin and plasminogen activator inhibitor-1 and excessive androgen are also risk factors of endometrial cancer. High levels of insulin induced by insulin resistance have been found to exert direct and indirect effects that contribute to the development of endometrial cancer. Insulin directly promotes cell proliferation and survival through the PI3K/Akt and Ras/MAPK pathways. Moreover, the network among insulin, estrogen and insulin-like growth factor-1 also contributes to the development of endometrial cancer. Indirectly, insulin leads to changes in sex hormone levels, including increases in the levels of estrogen. Additionally, a small number of studies suggested that metformin, an insulin-sensitizing agent, has therapeutic potential for endometrial cancer" - See metformin at The Antiaging Store.
  • Legume, Soy, Tofu, and Isoflavone Intake and Endometrial Cancer Risk in Postmenopausal Women in the Multiethnic Cohort Study - J Natl Cancer Inst. 2011 Dec 12 - "conducted a prospective analysis of 46 027 nonhysterectomized postmenopausal women who were recruited into the Multiethnic Cohort (MEC) Study between August 1993 and August 1996 and provided detailed baseline information on diet and other endometrial cancer risk factors ... A total of 489 women diagnosed with incident endometrial cancer were identified through the Surveillance, Epidemiology, and End Results tumor registry linkages during a median follow-up period of 13.6 years ... A reduced risk of endometrial cancer was associated with total isoflavone intake (highest vs lowest quintile, ≥7.82 vs <1.59 mg per 1000 kcal/d, RR = 0.66, 95% CI = 0.47 to 0.91), daidzein intake (highest vs lowest quintile, ≥3.54 vs <0.70 mg per 1000 kcal/d, RR = 0.64, 95% CI = 0.46 to 0.90), and genistein intake (highest vs lowest quintile, ≥3.40 vs <0.69 mg per 1000 kcal/d, RR = 0.66, 95% CI = 0.47 to 0.91). No statistically significant association with endometrial cancer risk was observed for increasing intake of legumes, soy, tofu, or glycitein. Truncated age-adjusted incidence rates of endometrial cancer for the highest vs lowest quintile of total isoflavone intake were 55 vs 107 per 100 000 women per year, respectively. The partial population attributable risk percent for total isoflavone intake lower than the highest quintile was 26.7% (95% CI = 5.3% to 45.8%)" - See soy isoflavones at Amazon.com.
  • A Prospective Cohort Study of Coffee Consumption and Risk of Endometrial Cancer over a 26-Year Follow-Up - Cancer Epidemiol Biomarkers Prev. 2011 Nov 22 - "Coffee has been reported to lower levels of estrogen and insulin, two hormones implicated in endometrial carcinogenesis, but prospective data on the relation between coffee consumption and risk of endometrial cancer are limited ... Fewer than 4 cups of coffee per day were not associated with endometrial cancer risk. However, women who consumed 4 or more cups of coffee had 25% lower risk of endometrial cancer than those who consumed less than 1 cup per day (multivariable RR = 0.75; 95% CI = 0.57-0.97; P(trend) = 0.02). We found the similar association with caffeinated coffee consumption (RR for ≥4 vs. <1 cup/d = 0.70; 95% CI = 0.51-0.95). For decaffeinated coffee consumption, a suggestive inverse association was found among women who consumed 2 or more cups per day versus <1 cup/mo. Tea consumption was not associated with endometrial cancer risk"
  • Metformin Treatment Exerts Antiinvasive and Antimetastatic Effects in Human Endometrial Carcinoma Cells - J Clin Endocrinol Metab. 2010 Dec 29 - "In vitro invasion in ECC-1 cells was significantly attenuated by sera from PCOS women after 6 months of metformin treatment (850 mg twice daily) compared to matched controls (P < 0.01). These effects appear to be associated with NF-κB, MMP-2/9, as well as Akt and Erk1/2 pathways that are known to be important regulators of inflammation, tumor invasion and metastasis. Conclusions: Metformin, potentially, may serve as adjuvant treatment in the management of patients with endometrial cancer"
  • Exercise may reduce risk of endometrial cancer - Science Daily, 11/9/10 - "Those who exercised for 150 minutes a week or more had a 34 percent reduced risk of endometrial cancer compared with those women who were inactive"
  • Vitamin D protects against obesity-induced endometrial cancer, study suggests - Science Daily, 9/21/10 - "25 percent of obese mice fed a vitamin D supplemented diet developed endometrial cancer, while 67 percent of obese mice not treated with the vitamin developed cancer ... vitamin D offered no protective effects for normal weight mice ... Vitamin D has been shown to be helpful in a number of cancers, but for endometrial cancer, our study suggests it protects only against cancer that develops due to obesity ... Still, if these results are confirmed in women, use of vitamin D may be a wonderfully simple way to reduce endometrial cancer risk" - See vitamin D at Amazon.com.
  • Coffee and tea consumption and endometrial cancer risk in a population-based study in New Jersey - Cancer Causes Control. 2010 May 14 - "There was a moderate inverse association with coffee consumption, with an adjusted OR of 0.65 (95% CI: 0.36-1.17) for women who reported more than two cups/day of coffee compared to none. Tea consumption appeared to increase risk (OR: 1.93; 95% CI: 1.08-3.45), but after including the variables sugar/honey and cream/milk added to tea in the model, the risk estimate was attenuated and no longer statistically significant (OR: 1.77; 95% CI: 0.96-3.28 for those consuming more than one cup/day of tea compared to nonusers). There was a suggestion of a decreased risk associated with green tea, but the confidence interval included one (adjusted OR for one or more cups/week vs. none: 0.75; 95% CI: 0.48-1.18). We found an association with adding sugar/honey to tea, with those adding two or more teaspoons/cup having an OR of 2.66 (95% CI: 1.42-4.98; p for trend <0.01) after adjusting for relevant confounders. For sugar/honey added to coffee the corresponding OR was 1.43 (95% CI: 0.81-2.55). Our results indicate that sugars and milk/cream added to coffee and tea should be considered in future studies evaluating coffee and tea and endometrial cancer risk"
  • Dietary iron intake and risk of endometrial cancer: a population-based case-control study in Shanghai, China - Nutr Cancer. 2010;62(1):40-50 - "Dietary red meat and animal fat have been linked to endometrial cancer (EC) risk, but the impact of bioavailable iron in animal-derived foods has been less well studied ... Animal-derived iron intake was positively associated with EC risk [adjusted OR = 1.9; 95% CI = 1.4-2.7, P(trend) < 0.01, highest vs. lowest quartile], predominantly after menopause (OR = 2.2; 95%CI = 1.4-3.4, P(trend) < 0.01) and in women with BMI >or= 25 kg/m(2)(OR = 3.2; 95% CI = 1.4-7.5 in postmenopausal obese women, P(trend) < 0.01). Animal-derived fat was also associated with postmenopausal EC risk (OR = 1.7; 95% CI = 1.2-2.5, P(trend) < 0.01). Multiplicative interactions between animal-derived iron and BMI or animal-derived fat intake were not observed. Animal-derived iron intake is associated with increased risk of EC after menopause and among obese women. Avoidance of animal-derived (heme) iron may reduce the risk of EC in these women"
  • Coffee drinking and risk of endometrial cancer-A population-based cohort study - Int J Cancer. 2009 Apr 27 - "Each additional cup (200 g) of coffee per day was associated with a rate ratio (RR) of 0.90 [95% confidence interval (CI), 0.83-0.97]. In women drinking 4 or more cups of coffee a day, the RR for the risk reduction of endometrial cancer was 0.75 (95% CI, 0.58-0.97) when compared with those who drank 1 cup or less"
  • Antioxidant vitamins may protect against female cancer - Nutra USA, 6/3/09 - "for every 1,000 microgram increase per 1,000 kcal of diet of beta-carotene was associated with a 12 per cent reduction in the risk of endometrial cancer ... Similarly, for every 50 milligram increase per 1,000 kcal of vitamin C the risk of endometrial cancer was reduced by 15 per cent, and for every 5 milligram increase per 1,000 kcal of vitamin E the risk of endometrial cancer was reduced by 9 per cent" - [Abstract]
  • Antioxidant vitamins and the risk of endometrial cancer: a dose-response meta-analysis - Cancer Causes Control. 2009 Jul;20(5):699-711 - "Based on case-control data, the random-effects summary odds ratios (OR) were, for beta-carotene: 0.88 (95% CI: 0.79-0.98) per 1,000 mcg/1,000 kcal (I2: 77.7%; p < 0.01); for vitamin C: 0.85 (95% CI: 0.73-0.98) per 50 mg/1,000 kcal (I2: 66.1%; p < 0.01); and, for vitamin E: 0.91 (95% CI: 0.84-0.99) per 5 mg/1,000 kcal (I2: 0.0%; p: 0.45)"
  • Higher regular coffee and tea consumption is associated with reduced endometrial cancer risk - Int J Cancer. 2008 Oct 30 - "Compared to nondrinkers, we observed a nonsignificant negative association with endometrial cancer risk among women who reported >2 cups/d regular coffee (OR 0.71, 95% CI 0.49-1.03), a significant inverse association with >2 cups/d black tea (OR 0.56, 95% CI 0.35-0.90) and a significant inverse association with >4 cups/d combined coffee and tea consumption (OR 0.47, 95% CI 0.28-0.80). These findings suggest coffee and tea may be important in reducing endometrial cancer risk"
  • Antioxidant vitamins and the risk of endometrial cancer: a dose-response meta-analysis - Cancer Causes Control. 2008 Dec 16 - "Based on case-control data, the random-effects summary odds ratios (OR) were, for beta-carotene: 0.88 (95% CI: 0.79-0.98) per 1,000 mcg/1,000 kcal (I(2): 77.7%; p < 0.01); for vitamin C: 0.85 (95% CI: 0.73-0.98) per 50 mg/1,000 kcal (I(2): 66.1%; p < 0.01); and, for vitamin E: 0.91 (95% CI: 0.84-0.99) per 5 mg/1,000 kcal (I(2): 0.0%; p: 0.45)"
  • Coffee consumption and risk of endometrial cancer: A prospective study in Japan - Int J Cancer. 2008 Aug 18 - "After adjustment for age, study area, body mass index, menopausal status, age at menopause for postmenopausal women, parity, use of exogenous female hormones, smoking status and by consumption of green vegetables, beef, pork and green tea, the multivariate HRs (95% CI) of endometrial cancer in women who drank coffee </=2 days/week, 3-4 days/week, 1-2 cups/day and >/=3 cups/day were 1.00, 0.97 (0.56-1.68), 0.61 (0.39-0.97) and 0.38 (0.16-0.91), respectively ... Coffee consumption may be associated with a decreased risk of endometrial cancer"
  • Glycemic index, glycemic load, and cancer risk: a meta-analysis - Am J Clin Nutr. 2008 Jun;87(6):1793-801 - "Overall, both GL and GI were significantly associated with a greater risk of colorectal (summary RR = 1.26; 95% CI: 1.11, 1.44 and RR = 1.18; 95% CI: 1.05, 1.34, respectively) and endometrial (RR = 1.36; 95% CI: 1.14, 1.62 and RR = 1.22; 95% CI: 1.01, 1.49) cancer than of breast and pancreatic cancer"
  • Meta-analysis supports fibre for uterus cancer protection - Nutra USA, 12/18/07 - "For every five grams of dietary fibre per 1000 calories, women may reduce their risk of endometrial cancer by over 20 per cent" - [Abstract]
  • Association between dietary fiber and endometrial cancer: a dose-response meta-analysis - Am J Clin Nutr. 2007 Dec;86(6):1730-7 - "the random-effects summary risk estimate was 0.82 (95% CI: 0.75, 0.90) per 5 g/1000 kcal dietary fiber"
  • Deficiency In Exposure To Sunlight Linked To Endometrial Cancer - Science Daily, 11/14/07 - "In general, endometrial cancer incidence was highest at the highest latitudes in both hemispheres ... This is the third environmental paper from this research team to show a strong association between vitamin D and cancer using global incidence data (GLOBOCAN). The first paper, which illuminated a similar pattern for kidney cancer, was published Sept. 15, 2006, in the International Journal of Cancer. The second, on ovarian cancer, was published Oct. 31, 2006, in the American Journal of Preventive Medicine" - See vitamin D at Amazon.com.
  • Night Shift Work and the Risk of Endometrial Cancer - Cancer Res. 2007 Nov 1;67(21):10618-10622 - "Women who worked 20+ years of rotating night shifts had a significantly increased risk of endometrial cancer [MVRR, 1.47 ... obese women working rotating night shifts doubled their baseline risk of endometrial cancer (MVRR, 2.09; 95% CI, 1.24-3.52) compared with obese women who did no night work ... Women working rotating night shifts for a long duration have a significantly increased risk of endometrial cancer, particularly if they are obese. We speculate that this increased risk is attributable to the effects of melatonin on hormonal and metabolic factors" - See melatonin at Amazon.com.
  • Lots of Soy Lessens Endometrial Cancer Risk - WebMD, 5/27/04 - "Regular intake of soya foods is associated with a reduced risk of endometrial cancer"
  • Physical Activity May Reduce Endometrial Cancer Risk - Doctor's Guide, 3/31/04
  • Phytoestrogens May Shield Against Endometrial Cancer - Natural Foods Merchandiser, 11/03
  • Soy May Cut Endometrial Cancer Risk - WebMD, 8/5/03 - "consumption of isoflavones and lignans, but not coumestans, were associated with a reduced risk of endometrial cancer, particularly among postmenopausal women" - See Revival Soy Products.
  • Glycemic index and glycemic load in endometrial cancer - Int J Cancer. 2003 Jun 20;105(3):404-7 - "Our study supports the hypothesis of a direct association between GI and endometrial cancer risk"

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