Recent Longevity News for the seven days ending 11/27/13.  You should consult your doctor if you are taking any medications.

How the 'Love Hormone' Works Its Magic - WebMD, 11/25/13 - "the hormone appears to boost men's attraction to their mate -- even when presented with pictures of other women ... 20 men who were in committed relationships for 28 months, on average, took whiffs of either oxytocin nasal spray or an inactive placebo spray ... Men consistently rated their partners as being more attractive and arousing than the other women and, in most cases, a whiff of oxytocin boosted that effect compared to the placebo" - See Oxy Pro (Oxytocin) Nasal Spray at International Anti-aging Systems.

FDA Lifts Avandia Prescribing Restrictions - Medscape, 11/25/13 - "Although some scientific uncertainty about the cardiovascular safety of rosiglitazone medicines still remains, in light of the new re-evaluation of the Rosiglitazone Evaluated for Cardiovascular Outcomes and Regulation of Glycemia in Diabetes (RECORD) trial, our concern is substantially reduced ... Once the changes are final, the FDA anticipates that rosiglitazone's indication will be similar to those of other diabetes drugs"

Step away from that soda: Sugary drinks raise cancer risk for women, study finds - NBC News.com, 11/22/13 - "endometrial cancer ... Women who drank the most sweet soft drinks had a 78 percent increased risk of the cancer, researchers found. But other sweet treats, such as baked goods, didn’t have an effect. Nor did natural fruit juice, even though it’s full of naturally occurring sugars ... It has to do with how insulin, which controls how the body uses sugar, affects other hormones such as estrogen"

Excessive testosterone raises mortality risk in older men - Science Daily, 11/22/13 - "Men with circulating testosterone levels in the 9.8 to 15.8 nmol/L range tended to live longer"

Calcium Supplements and Cardiovascular Risk - Medscape, 11/22/13 - "Any benefit of calcium supplements on preventing fracture is outweighed by increased cardiovascular events. While there is little evidence to suggest that dietary calcium intake is associated with cardiovascular risk, there is also little evidence that it is associated with fracture risk. Therefore, for the majority of people, dietary calcium intake does not require close scrutiny. Because of the unfavorable risk/benefit profile, widespread prescribing of calcium supplements to prevent fractures should be abandoned"

Men's sexual desire linked to prolactin levels - NBC News.com, 11/20/13 - "researchers looked at nearly 3,000 European men ages 40 to 79, and measured their testosterone and prolactin levels, body mass indexes (BMIs), and blood cholesterol and sugar levels ... low prolactin was linked to several signs of poor sexual health, as well psychological health. Men with levels of prolactin that were lower than average, although still within the normal range, were more likely than men with higher levels to say their sexual function was getting worse, particularly their enjoyment of orgasm. They also had more symptoms of depression ... Low prolactin was also associated with higher BMI and blood sugar, lower levels of physical activity, and generally feeling unhealthier ... Studies have found that high prolactin levels in men are linked to low sexual desire and erectile dysfunction, and men suffering from such conditions are sometimes tested for high prolactin levels ... Some previous research supports the new finding, the researchers said. Two animal studies have shown that using drugs to increase prolactin levels in rats boosted their sexual behavior"

Children's Cardiovascular Fitness Declining Worldwide - Science Daily, 11/20/13 - "In the United States, kids' cardiovascular endurance fell an average 6 percent per decade between 1970 and 2000 ... In a mile run, kids today are about a minute and a half slower than their peers 30 years ago"

Coffee May Help Perk Up Your Blood Vessels - Science Daily, 11/20/13 - "A study of 27 healthy adults showed -- for the first time -- that drinking a cup of caffeinated coffee significantly improved blood flow in a finger, which is a measure of how well the inner lining of the body's smaller blood vessels work. Specifically, participants who drank a cup of caffeinated coffee had a 30 percent increase in blood flow over a 75-minute period compared to those who drank decaffeinated coffee"

Probiotics a Potential Treatment for Mental Illness - Medscape, 11/19/13 - "although human studies are still largely lacking, they did find some with promising results on behavior, including 1 showing that healthy volunteers who received Lactobacillus helveticus R0052 plus B longum for 30 days reported significantly lower stress levels than those who received placebo, as well as significantly reduced urinary free cortisol levels ... Another study of 124 volunteers (mean age, 61.8 years) showed that those who consumed probiotic-containing yogurt for 3 weeks had significantly improved mood compared with those who received placebo ... the term "psychobiotic" was created as recent studies have begun to explore a possible link between probiotics and behavior ... As a class of probiotic, these bacteria are capable of producing and delivering neuroactive substances such as gamma-aminobutyric acid [GABA] and serotonin, which act on the brain-gut axis ... a study of human patients with chronic fatigue syndrome showed that those who consumed an active strain of L casei 3 times a day had significantly higher improvement scores on anxiety measures than did those who received matching placebo" - See probiotic products at Amazon.com.

Natural compound mitigates effects of methamphetamine abuse - Science Daily, 11/19/13 - "Resveratrol has been shown to regulate these dopamine neurons and to be protective in Parkinson's disease, a disorder where dopamine neurons degenerate ... rats received resveratrol once a day for seven days in about the same concentration as a human would receive from a healthy diet. After a week of resveratrol, researchers measured how much dopamine was released by methamphetamine. Researchers found that resveratrol significantly diminished methamphetamine's ability to increase dopamine levels in the brain. Furthermore, resveratrol diminished methamphetamine's ability to increase activity in mice, a behavior that models the hyperactivity observed in people that use the stimulant"

Abstracts from this week's Doctor's Guide Nutrition/Dietetics plus abstracts from my RSS feeds (Click here for the journals, the PubMed ones at the top):

ACE Inhibitor and Angiotensin Receptor Blocker Use and Mortality in Patients with Chronic Kidney Disease - J Am Coll Cardiol. 2013 Nov 6 - "A logistic regression analysis was used to calculate the propensity of ACEI/ARB initiation in 141,413 US veterans with non-dialysis CKD previously unexposed to ACEI/ARB treatment ... inverse probability treatment weighing (IPTW) ... ACEI/ARB administration was associated with significantly lower risk of mortality both in the intention-to-treat analysis (HR=0.81; 95%CI: 0.78-0.84, p<0.001) and in the as-treated analysis with IPTW (OR=0.37; 95%CI: 0.34-0.41, p<0.001)"

Lemon balm extract causes potent antihyperglycemic and antihyperlipidemic effects in insulin-resistant obese mice - Mol Nutr Food Res. 2013 Nov 24 - "we describe the application of ethanolic lemon balm (Melissa officinalis) leaves extract for the treatment of insulin-resistance and dyslipidemia in mice. We show that lemon balm extract (LBE) activates the peroxisome proliferator-activated receptors (PPARs), which have key roles in the regulation of whole body glucose and lipid metabolism. Application of LBE (0.6 mg/mL) to human primary adipocytes resulted in specific peroxisome proliferator-activated receptor target gene expression. LBE treatment of insulin-resistant high-fat diet-fed C57BL/6 mice (200 mg/kg/day) for 6 weeks considerably reduced hyperglycemia and insulin resistance, plasma triacylglycerol, nonesterified fatty acids and LDL/VLDL cholesterol levels. Taken together, ethanolic lemon balm extract can potentially be used to prevent or concomitantly treat type 2 diabetes and associated disorders such as dyslipidemia and hypercholesterolemia" - See lemon balm products at iHerb.

Sugar-Sweetened Beverage Intake and the Risk of Type I and Type II Endometrial Cancer among Postmenopausal Women - Cancer Epidemiol Biomarkers Prev. 2013 Nov 22 - "We evaluated dietary intake of SSB, fruit juice, sugar-free beverages, sweets/baked goods, starch, and sugars among 23,039 postmenopausal women in the Iowa Women's Health Study ... Compared with nondrinkers of SSB, the risk was 78% higher [95% confidence intervals (CI), 1.32-2.40] among women in the highest quintile of SSB intake"

An Increase in the EPA/AA Ratio is Associated with Improved Arterial Stiffness in Obese Patients with Dyslipidemia - J Atheroscler Thromb. 2013 Nov 22 - "88 patients received either highly purified EPA treatment(1.8g daily, n=45) or treatment without EPA(control, n=43) ... These findings suggest that EPA improves the arterial stiffness in association with an increase in the EPA/AA ratio and a decrease in inflammation in obese patients with dyslipidemia" - See Mega Twin EPA at Amazon.com.

Mechanism-based inhibition of cancer metastasis with (-)-epigallocatechin gallate - Biochem Biophys Res Commun. 2013 Nov 21 - "Cell motility and cell stiffness are closely related to metastatic activity of cancer cells. (-)-Epigallocatechin gallate (EGCG) has been shown to inhibit spontaneous metastasis of melanoma cell line into the lungs of mice ... Treatments of human non-small cell lung cancer cell lines H1299 and Lu99 with 50 and 100 μM EGCG reduced cell motility to 67.5% and 43.7% in H1299, and 71.7% and 31.5% in Lu99, respectively in in vitro wound healing assay. Studies on cell stiffness using atomic force microscope (AFM) revealed that treatment with 50 μM EGCG increased Young's modulus of H1299 from 1.24 to 2.25 kPa and that of Lu99 from 1.29 to 2.28 kPa, showing a 2-fold increase cell stiffness, i.e. rigid elasticity of cell membrane" - See green tea extract at Amazon.com.

• Epigallocatechin gallate - Wikipedia, the free encyclopedia - "EGCG is the most abundant catechin in tea and is a potent antioxidant that may have therapeutic applications in the treatment of many disorders (e.g. cancer). It is found in green tea, but not black tea; during black tea production, the catechins are converted to theaflavins and thearubigins.[3] It is also found in various vegetables, nuts, as well as carob powder at 109 mg per 100g"

Probiotic supplementation for respiratory and gastrointestinal illness symptoms in healthy physically active individuals - Clin Nutr. 2013 Oct 10 - "Four hundred and sixty five participants (241 males; age 35 ± 12 y (mean ± SD) and 224 females; age 36 ± 12 y) were assigned to one of three groups: Group 1 - Bifidobacterium animalis subsp. lactis Bl-04 (Bl-04) 2.0 × 109colony forming units per day, CFU per day, Group 2 - Lactobacillus acidophilus NCFM and Bifidobacterium animalis subsp. lactis Bi-07 (NCFM & Bi-07) 5 × 109 CFU each per day) or Group 3 - placebo mixed in a drink ... The risk of an upper respiratory illness episode was significantly lower in the Bl-04 group (hazard ratio 0.73; 95% confidence interval 0.55-0.95; P = 0.022) compared to placebo. There was no significant difference in illness risk between the NCFM & Bi-07 group (hazard ratio 0.81; 0.62-1.08; P = 0.15) and the placebo group. There was a 0.7 and 0.9 month delay in the median time to an illness episode in the Bl-04 and NCFM & Bi-07 groups respectively compared to placebo (placebo 2.5 months; Bl-04 3.2 months; NCFM & Bi-07 3.4 months). There were insufficient GI illness episodes for analysis" - See Bifidobacterium animalis products at iHerb.

• Activia - Wikipedia, the free encyclopedia - "Activia products thus contain Bifidobacterium animalis DN 173,010, a proprietary strain of Bifidobacterium, a probiotic which is marketed by Dannon under the trade names Bifidus Regularis, Bifidus Actiregularis, Bifidus Digestivum and Bifidobacterium Lactis" - See my yogurt recipe which is made with Activia on my yogurt page.

Dairy Foods and Dairy Protein Consumption Is Inversely Related to Markers of Adiposity in Obese Men and Women - Nutrients. 2013 Nov 20;5(11):4665-4684 - "We sought to examine relationships between energy, protein and calcium consumption from dairy foods (milk, yoghurt, cheese, dairy spreads, ice-cream) and adiposity including body mass index (BMI), waist (WC) and hip circumference (HC), and direct measures of body composition using dual energy X-ray absorptiometry (% body fat and abdominal fat) in an opportunistic sample of 720 overweight/obese Australian men and women ... Overall dairy food consumption (g/day) was inversely associated with BMI, % body fat and WC (all p < 0.05). Dairy protein and dairy calcium (g/day) were both inversely associated with all adiposity measures (all p < 0.05). Yoghurt consumption (g/day) was inversely associated with % body fat, abdominal fat, WC and HC (all p < 0.05), while reduced fat milk consumption was inversely associated with BMI, WC, HC and % body fat (all p < 0.05). Within a sample of obese adults, consumption of dairy products, dairy protein, and calcium was associated with more favourable body composition" - Click here for my yogurt recipe.

Association of Nut Consumption with Total and Cause-Specific Mortality - N Engl J Med. 2013 Nov 21 - "We examined the association between nut consumption and subsequent total and cause-specific mortality among 76,464 women in the Nurses' Health Study (1980-2010) and 42,498 men in the Health Professionals Follow-up Study (1986-2010) ... The pooled multivariate hazard ratios for death among participants who ate nuts, as compared with those who did not, were 0.93 (95% confidence interval [CI], 0.90 to 0.96) for the consumption of nuts less than once per week, 0.89 (95% CI, 0.86 to 0.93) for once per week, 0.87 (95% CI, 0.83 to 0.90) for two to four times per week, 0.85 (95% CI, 0.79 to 0.91) for five or six times per week, and 0.80 (95% CI, 0.73 to 0.86) for seven or more times per week" - Note:  Yeah but no study will every make me believe that it doesn't pack on the pounds.

Relations of raw and cooked vegetable consumption to blood pressure: the INTERMAP Study - J Hum Hypertens. 2013 Nov 21 - "Here we report cross-sectional associations of vegetable intakes with BP for 2195 Americans ages 40-59 in the International Study of Macro/Micronutrients and Blood Pressure (INTERMAP) using four standardized multi-pass 24-h dietary recalls and eight BP measurements ... Estimated average systolic BP differences associated with two s.d. differences in raw vegetable intake (68 g per 1000 kcal) and cooked vegetable intake (92 g per 1000 kcal) were -1.9 mm Hg (95% confidence interval (CI): -3.1, -0.8; P=0.001) and -1.3 mm Hg (95% CI: -2.5, -0.2; P=0.03) without body mass index (BMI) in the full model; -1.3 mm Hg (95% CI: -2.4, -0.2; P=0.02) and -0.9 mm Hg (95% CI: -2.0, 0.2; P=0.1) with additional adjustment for BMI. Among commonly consumed individual raw vegetables, tomatoes, carrots, and scallions related significantly inversely to BP. Among commonly eaten cooked vegetables, tomatoes, peas, celery, and scallions related significantly inversely to BP"

Myofibrillar muscle protein synthesis rates subsequent to a meal in response to increasing doses of whey protein at rest and after resistance exercise - Am J Clin Nutr. 2013 Nov 20 - "muscle protein synthesis (MPS) ... A 20-g dose of whey protein is sufficient for the maximal stimulation of postabsorptive rates of myofibrillar MPS in rested and exercised muscle of ~ 80-kg resistance-trained, young men. A dose of whey protein >20 g stimulates amino acid oxidation and ureagenesis" - See whey protein at Amazon.com.

In Older Men an Optimal Plasma Testosterone Is Associated With Reduced All-Cause Mortality and Higher Dihydrotestosterone With Reduced Ischemic Heart Disease Mortality, While Estradiol Levels Do Not Predict Mortality - J Clin Endocrinol Metab. 2013 Nov 20 - "Participants were community-dwelling men aged 70 to 89 years who were residing in Perth, Western Australia ... E2 was not associated with either all-cause or IHD mortality ... Optimal androgen levels are a biomarker for survival because older men with midrange levels of T and DHT had the lowest death rates from any cause, whereas those with higher DHT had lower IHD mortality"

L-Arginine Supplementation Prevents Increases in Intestinal Permeability and Bacterial Translocation in Male Swiss Mice Subjected to Physical Exercise under Environmental Heat Stress - J Nutr. 2013 Nov 20 - "core body temperature (Tcore) ... Our results indicate that dietary l-arginine supplementation preserves the integrity of the intestinal epithelium during exercise under heat stress, acting through mechanisms that are independent of Tcore regulation" - See L-arginine products at Amazon.com.

Zinc Absorption by Young Adults from Supplemental Zinc Citrate Is Comparable with That from Zinc Gluconate and Higher than from Zinc Oxide - J Nutr. 2013 Nov 20 - "We used the double-isotope tracer method with 67Zn and 70Zn to measure zinc absorption from zinc citrate given as supplements containing 10 mg of zinc to 15 healthy adults without food and compared absorption with that from zinc gluconate and zinc oxide (insoluble in water) using a randomized, double-masked, 3-way crossover design. Median (IQR) fractional absorption of zinc from zinc citrate was 61.3% (56.6-71.0) and was not different from that from zinc gluconate with 60.9% (50.6-to 71.7). Absorption from zinc oxide at 49.9% (40.9-57.7) was significantly lower than from both other supplements" - See zinc supplements at Amazon.com.

Dietary Magnesium Intake Is Inversely Associated with Mortality in Adults at High Cardiovascular Risk - J Nutr. 2013 Nov 20 - "The present study included 7216 men and women aged 55-80 y from the PREDIMED (Prevención con Dieta Mediterránea) study, a randomized clinical trial. Participants were assigned to one of two Mediterranean diets (supplemented with nuts or olive oil) or advice on a low-fat control diet ... median follow-up of 4.8 y ... Energy-adjusted baseline magnesium intake was inversely associated with cardiovascular, cancer, and all-cause mortality. Compared with lower consumers, individuals in the highest tertile of magnesium intake had a 34% reduction in mortality risk (HR: 0.66; 95% CI: 0.45, 0.95; P < 0.01). Dietary magnesium intake was inversely associated with mortality risk in Mediterranean individuals at high risk of CVD" - See Jarrow Formulas, MagMind at Amazon.com.

The relationship between metformin therapy and sleep quantity and quality in patients with Type 2 diabetes referred for potential sleep disorders - Diabet Med. 2013 Nov 16 - "Given that sleep disorders are known to be related to insulin resistance, and metformin has favourable effects on insulin resistance and on ventilatory drive, we sought to determine whether metformin therapy was related to sleep variables in a group of patients with Type 2 diabetes ... Total sleep time and sleep efficiency were higher in metformin-treated patients than in patients not treated with metformin [total sleep time: 6 h 39 min vs. 6 h 3 min, respectively (P = 0.002); sleep efficiency: 77.9 +/- 12.3 vs. 71.5 +/- 17.2%, respectively" - See metformin at The Antiaging Store.

Monosodium glutamate intake is inversely related to the risk of hyperglycemia - Clin Nutr. 2013 Nov 1 - "We followed 1056 healthy adults aged 20 years and older from 2002 to 2007. Dietary data were collected during home visits using a 3-day food record and a food frequency questionnaire ... The highest quartile of MSG intake was associated with a lower risk of incident hyperglycemia, even after adjustment for a number of covariates, including dietary patterns. Comparing the highest with the lowest quartiles of MSG intake, the odds ratio (OR) for hyperglycemia was 0.30 (95% CI 0.13-0.66). There was a linear inverse association between MSG intake and change in blood glucose"

Neat Tech Stuff / "How To's":

Ooma Office review: This VoIP-based phone system makes small businesses seem big - PCWorld, 11/20/13 - "Pros ... Excellent voice quality ... Supports multiple phone lines and extensions ... Calls can be transferred to remote employees ... Terrific price-to-performance ratio ... Cons ... Virtual receptionist's synthesized voice quality isn't the best ... Must prepay for international calls ... Only one greeting for business hours and one for off hours" - See Ooma Office Business Phone System with Virtual Receptionist.  I've got the home version.  It costs about $3.70 per month for the taxes on the phone number.  See Ooma Telo Free Home Phone Service.

NEW - Powerful Corded Micro-pedi Callus Remover By Emjoi (Latest Edition) - I just replaced my antique version with this.  I've been jogging (and swimming) since Moby-Dick was a minnow and these are a must have, not for calluses but to remove the dead skin from your heels.  Also see NEW! - Emjoi Micro-Pedi Xtreme Coarse Rollers (Roughest and Toughest Calluses).

Health Focus (Deprenyl/Selegiline):

Related Topics:

• dopamine / Monoamine Oxidase (MAO) Inhibitors / antidepressants / Parkinson's Disease / depression / attention deficient hyperactive disorder

Where to purchase:

• Deprenyl at International Anti-aging Systems

News & Research:

• Deprenyl - extending lifespan - article by James South - "At normally used clinical dosages (10-15 mg/day), deprenyl is a selective MAO-B inhibitor, so it doesn’t prevent intestinal MAO-A from digesting dietary tyramine. (1) In addition, deprenyl has the unique ability to prevent tyramine from getting into noradrenalin-using nerve calls, and it’s only when tyramine enters noradrenalin nerve cells that control arterial blood pressure that it triggers the “cheese effect.”"
• Deprenyl- A multi-functional anti-aging drug - Ward Dean MD - "In addition to its potential as a life-extending drug, Deprenyl also appears to have a number of other beneficial effects. One of the most significant is its libido promoting/aphrodisiac effects, in both men and women. . . . Deprenyl has also been found to protect neurons from toxic substances, act as an anti-oxidant, and as an inducer of the anti-oxidant enzymes superoxide dismutase (SOD) and catalase (CAT)"
• Deprenyl - International Antiaging Systems
• Deprenyl: A Universal Anti-Aging Strategy - CERI
• The Responsible Parent's Guide to Healthy Mood-Boosters for all the Family - BLTC Research
• Selegiline transdermal system promising for social phobia - Clinical Psychiatry News, 6/26/13 - "Twenty patients participated in this 12-week, open-label, pilot study. They were treated with the selegiline transdermal system (Emsam) at a dose of 6 mg/24 hours. They demonstrated a significant mean 7.1-point drop from a baseline score of 17.6 on the avoidance component of the Liebowitz Social Anxiety Scale, as well as a 6.6-point drop on the scale’s anxiety component, a result that just missed statistical significance ... Selegiline is an MAO-A and -B inhibitor. Its transdermal administration bypasses the GI tract and liver, thereby essentially eliminating the risks of hypertensive crisis and dietary interactions with tyramine-rich foods, which have demoted the traditional oral monoamine oxidase (MAO) inhibitors in antidepressant treatment hierarchies ... In addition to the favorable results on the Liebowitz Social Anxiety Scale over the course of 12 weeks, participants also showed statistically significant improvements on the Social Life/Leisure Activities domain of the Sheehan Disability Scale, the Clinical Global Impression Severity of Illness Scale, and the Clinical Global Impression Change Scale" - Note:  Emsam is the patch form of deprenyl (also called selegiline) which has been touted for anti-aging since around the '70's.  See deprenyl at International Anti-aging Systems.
• Study Will Test Antidepressant Patch That May Help Smokers Kick The Habit - Science Daily, 1/8/07
• Valeant Pharmaceuticals Announces Availability of Zelapar(R) for Parkinson's Disease Patients - Doctor's Guide, 7/21/06
• Patch Approval: ‘Big Moment’ in Psychopharm: Resistant depression patients may benefit - Clinical Psychiatry News, 4/06 - "Probably 30% of people who present with depressive complaints have an MAO-inhibitor responsive condition that will not respond well or not at all to [selective serotonin reuptake inhibitors, selective norepinephrine reuptake inhibitors, or tricyclics]"
• FDA Approves Emsam (selegiline transdermal system), the First Transdermal Patch for the Treatment of Major Depressive Disorder - Doctor's Guide, 2/28/06 - "the U.S. Food and Drug Administration (FDA) approved Emsam® (selegiline transdermal system), the first transdermal patch for the treatment of major depressive disorder (MDD) in adults"
• FDA OKs Patch to Treat Depression - WebMD, 2/28/06 - "At its lowest strength, Emsam can be used without the dietary restrictions that are needed for all oral MAO inhibitors that are approved for treating major depression"
• FDA Panel Backs Selegiline Patch For Depression: Majority view 20-mg formulation as safe - Clinical Psychiatry News, 12/05 - "Unlike the transdermal formulation, the oral formulation does not achieve antidepressant levels in the central nervous system"
• Fast-dissolving Selegiline (Zelapar Zydis) Reduces "Off-Time" in Up to 4 Years of Follow-Up - Doctor's Guide, 10/3/05
• Parkinson's Drug May Be Safer Than Thought - WebMD, 8/12/04
• Transdermal Selegiline Can Prevent Depression Relapse - Clinical Psychiatry News Online, 11/03
• Transdermal MAO Inhibitor Patch Effective for ADHD - Clinical Psychiatry News, 6/03 - "A transdermal patch containing the selective monoamine oxidase inhibitor selegiline applied daily appeared effective and well tolerated in a pilot study of children and adolescents with attention-deficit hyperactivity disorder ... Selegiline is a specific monoamine oxidase (MAO) type B inhibitor, so it “is essentially devoid of the tyramine-cheese effect we think about with MAO [type A] inhibitors"
• Selegiline Transdermal System Shows Modest But Significant Antidepressant Effect - Doctor's Guide, 3/19/03 - "Use of a selegiline transdermal system offers modest but statistically significant antidepressant benefit in outpatients with major depressive disorder"
• Zelapar (Selegiline) Receives Approvable Letter From FDA - Doctor's Guide, 2/18/03
• Parkinson's Drug May Help Smokers Quit - WebMD, 1/24/03
• Selegiline Helps Smokers Quit - Medscape, 1/23/03 - "Its effect was about half that of buproprion but comparable to that of nicotine replacement ... selegiline doses greater than 10 mg/day are associated with increased risk of hypertensive crises"
• Selegiline Might Aid Smoking Cessation - Doctor's Guide, 9/12/02
• Transdermal MAO Inhibitor Appears Safe Without Dietary Restrictions - Clinical Psychiatry News, 9/01 - "Selegiline is a MAO-B inhibitor that has been shown to have a significant antidepressant effect at oral doses of 30-60 mg/day. But at this level, the drug also inhibits MAO-A and requires the restriction of dietary tyramine and sympathomimetic amines"
• Deprenyl May Result In AD/HD Symptom Improvements - Doctor's Guide, 10/26/99 - "Ten children (ages six to 13) with AD/HD participated in the study. These children had very severe AD/HD and presented many co-morbid problems. Placebo and deprenyl tablets (5 mg) were given twice a day for one month each ... Results showed that three tasks were significantly improved (paired-associate learning, math computation and Beery shape copying) with deprenyl treatment as determined by a two-tailed statistical test. This pilot study indicates that deprenyl may have some benefits for the task performance and classroom behavior of some children with AD/HD."
• A Good Dose of Deprenyl How Much is Too Much? - Life Extension Magazine, 8/99
• Selegiline - BLTC Research
• Youthful Brain, Youthful Body - Life Extension Magazine, 5/98
• Effect Of Long-Term Deprenyl Treatment On Age-Dependent Changes In The Rat Brain - Life Extension Magazine, 9/96
• Top Ten Life Extension Drugs - Life Extension Magazine, 9/95
• Eldepryl Shows Encouraging Results In Alzheimer's Study - Doctor's Guide, 4/24/97
• Report: Vitamin E, Parkinson's drug slow Alzheimer's disease - CNN, 4/23/97

Abstracts:

• Selegiline transdermal system: a novel treatment option for major depressive disorder - Expert Opin Pharmacother. 2009 Jul;10(10):1665-73 - "Selegiline transdermal system is safe and effective in treating major depressive disorder at the dose range of 6 - 12 mg/24 h, without the need for dietary precautions at the 6 mg/24 h dose. No cases of hypertensive crisis were reported in clinical trials, even without dietary restrictions"
• Transdermal Selegiline in Major Depression: A Double-Blind, Placebo-Controlled, Parallel-Group Study in Outpatients - Am J Psychiatry, 11/02 - "Transdermal selegiline (20 mg applied once daily by means of a 20-cm2 patch) administered for 6 weeks was an effective and well-tolerated treatment for adult outpatients with major depression. The typical side effects commonly seen with traditional monoamine oxidase inhibitor antidepressants were not observed"
• MAO inhibitors and oxidant stress in aging brain tissue - Eur Neuropsychopharmacol. 1999 Mar;9(3):247-52 - "By reducing the oxidant stress observed in aging brain, MAO inhibitors, especially deprenyl, may contribute to the control of the aging process."
• Current status of antioxidant therapy for Alzheimer's Disease - J Am Geriatr Soc. 1998 Dec;46(12):1566-72 - "High dose vitamin E, ginkgo biloba, and selegiline are three putative antioxidants that have been tested in randomized multicenter trial conditions in the US"
• The striatal dopamine dependency of life span in male rats. Longevity study with (-)deprenyl - Mech Ageing Dev. 1988 Dec;46(1-3):237-62
• Integrated medicine and the prevention and reversal of memory loss - Altern Ther Health Med. 1998 Nov;4(6):38-43 - "The program includes a diet consisting of 15% fat and supplementation with brain-specific nutrients such as vitamin B complex, vitamin E, ubiquinone, ginkgo biloba, and phosphatidylserine. In addition, stress-relieving meditation, mind-body and cognitive exercise, antiaging drugs like L-deprenyl citrate, as well as hormones such as dehydroepiandrosterone and pregnenolone complete the program"
• Antitumor effect of L-deprenyl in rats with carcinogen-induced mammary tumors - Cancer Lett. 1998 Jan 30;123(2):177-83 - "These results suggest that the administration of deprenyl blocked the development of mammary tumors . . ."