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Anti-aging Research > Monoamine Oxidase
Monoamine Oxidase (MAO) Inhibitors
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News & Research:
- Myricitrin - a
flavonoid isolated from the Indian olive tree ( Elaeocarpus floribundus) -
inhibits Monoamine oxidase in the brain and elevates striatal dopamine
levels: therapeutic implications against Parkinson's disease - Food
Funct 2022 Jun 1 - "Flavonoids exhibit several
biological activities including inhibition of Monoamine oxidase (MAO), an
enzyme that metabolizes several neurotransmitters. Thus, MAO inhibitors are
well included in traditional therapeutic practices to fine-tune neuromotor
behavior ... Four flavonoids from Ef leaf extract, namely, myricitrin,
mearnsitrin, myricetin, and mearnsetin, are taken into consideration ... In
an in vitro setup, all four compounds inhibited total MAO, whereas
myricitrin exhibited some selectivity against MAO-B at 100 μM. Myricitrin
and mearnsitrin exhibited no toxicity, in vitro or in vivo. However, only
myricitrin inhibited MAO in the mouse brain and elevated dopamine levels.
Myricitrin was able to attenuate motor incoordination in the mouse model of
PD and improved dopamine levels in the striatum" - See
olive leaf extract at Amazon.com.
-
Deletion of monoamine
oxidase A in a prostate cancer model enhances anti-tumor immunity through
reduced immune suppression - Biochem Biophys Res Commun 2022 Oct 6 -
"We have previously shown that monoamine oxidase A (MAO
A) mediates prostate cancer growth and metastasis. Further, MAO A/Pten double
knockout (DKO) mice were generated and demonstrated that the deletion of MAO A
delayed prostate tumor development in the Pten knockout mouse model of prostate
adenocarcinoma ... Thus, MAO A inhibitor may alleviate immune suppression,
increase the antitumor immune response and be used for cancer immunotherapy"
- Note: Deprenyl is an old time anti-aging drug but it's a MOQ B inhibitor. I
don't know of any MAO A inhibitors.
-
Both inorganic and organic selenium supplements can decrease brain monoamine
oxidase B enzyme activity in adult rats - Br J Nutr. 2008 Feb 28;:1-6 -
"tocopherol group (T group, positive control),
selenite group (SE group, representing the inorganic Se group) and
seleno-yeast group (SY group, representing the organic Se group) ... MAO-B
activity showed a significant decrease in the T, SE and SY groups in rat
brains but no significant change could be noted in the rat livers. In
conclusion, the present study indicates that inorganic or organic Se
supplementation can decrease the brain MAO-B enzyme activity in adult rats
and can be accomplished by the effect of the Se antioxidation capability"
- See
selenium at Amazon.com
 .
-
Monoamine Oxidase Type B Inhibitors May Help in Early Parkinson's Disease
- Doctor's Guide, 8/13/04
- Hormones for
Perimenopausal and Postmenopausal Depression - Psychiatric Times, 1/04 -
"Estrogen inhibits
MAO, thereby diminishing the degradation of
norepinephrine and serotonin and thus
increasing their activity, while progesterone has the reverse impact on MAO"
-
Three Depression Subtypes Respond Selectively - Clinical Psychiatry
News, 1/03 -
"Psychotic
depression ... In general, the antidepressant
needs to be helped along by an adjunctive
antipsychotic agent or by ECT ... That
constellation of symptoms known as atypical depression seems to
preferentially respond to our old friends—the MAO inhibitors"
- Antidepressant
Relief in a Skin Patch - WebMD, 11/1/02
-
MAOIs Still Good for Depression Rescue - Clinical Psychiatry News, 6/02
-
Youthful Brain, Youthful Body - Life Extension Magazine, 5/98
- Clinical Advances In
Monoamine Oxidase Inhibitor Therapies - BLTC Research
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