Recent Longevity News for the seven days ending 1/19/11. You should consult your doctor if you are taking any medications.
Uric acid may increase likelihood of severe osteoarthritis - Science Daily, 1/18/11 - "The researchers looked at 159 people, who had knee osteoarthritis but no history of gout, a type of arthritis triggered by uric acid crystals in the joints. The researchers found the severity of osteoarthritis in their knees to be strongly correlated with the amount of uric acid in their knees. The results, which are published online in the Proceedings of the National Academy of Sciences, show, despite the lack of gout history, above normal uric acid levels in 39 percent of the study population, and evidence of the form of inflammation in the joints that is typically triggered by uric acid crystals"
Healthy gums, healthy lungs: Maintaining healthy teeth and gums may reduce risk for pneumonia, chronic obstructive pumonary disease - Science Daily, 1/18/11 - "patients with respiratory diseases had worse periodontal health than the control group, suggesting a relationship between respiratory disease and periodontal disease. Researchers suspect that the presence of oral pathogens associated with periodontal disease may increase a patient's risk of developing or exacerbating respiratory disease"
Vitamin D absorption is diminished in patients with Crohn's disease, researchers find - Science Daily, 1/18/11 - "CD patients had on average a 30 percent decrease in their ability to absorb vitamin D2 when compared to normal subjects"
Use of antidepressant associated with reduction in menopausal hot flashes - Science Daily, 1/18/11 - "In the escitalopram group, average hot flash frequency at week 8 decreased to 5.26 hot flashes per day (47 percent decrease or an average of 4.6 fewer hot flashes per day than at the beginning of the study). In the placebo group, hot flash frequency decreased to 6.43 hot flashes per day (33 percent decrease or an average of 3.2 fewer hot flashes per day)" - Note: A significant placebo effect. Some argue on trials like this that that the people receiving the real deal know because of the side effects of the medication therefore they have a greater placebo effect.
Rates of Suicidal Ideation Among US Surgeons 'Very Concerning' - Medscape, 1/17/11 - "The fact that 6% of US surgeons thought of killing themselves in the last 12 months is certainly very concerning ... even more striking considering that surgeons are highly educated, nearly universally employed, and overwhelmingly (88%) married — all factors known to reduce risk of suicide in the general population ... rates were substantially higher among surgeons age 45 to 54 years"
Essential oil pill prevents PMS, study suggests - Science Daily, 1/16/11 - "Women who were given capsules containing 2 grams of a combination of gamma linolenic acid, oleic acid, linoleic acid, other polyunsaturated acids and vitamin E reported significantly eased PMS symptoms at both 3 and 6 months after they began the treatment" - See borage oil at Amazon.com (GLA) and Jarrow FamilE (contains all eight members of the vitamin E family, includes Tocomin) at Amazon.com. Oleic acid is omega-9 in which olive oil is a good source. Linoleic acid is omega-6. Most Americans get about 10 to 20 times too much omega-6 to begin with (click here to Google it). I don't know why they included it. It makes me wonder about some of the researchers. If they are showing a benefit, I would guess it's from the other ingredients and not the omega-6. Gamma linolenic acid is an omega-6 also but it's a form that most don't get enough of.
Bioactive compounds in berries can reduce high blood pressure - Science Daily, 1/14/11 - "bioactive compounds in blueberries called anthocyanins offer protection against hypertension. Compared with those who do not eat blueberries, those eating at least one serving a week reduce their risk of developing the condition by 10 per cent" - See blueberry extract at Amazon.com.
Why coffee protects against diabetes - Science Daily, 1/12/11 - "A protein called sex hormone-binding globulin (SHBG) regulates the biological activity of the body's sex hormones, testosterone and estrogen, which have long been thought to play a role in the development of type 2 diabetes. And coffee consumption, it turns out, increases plasma levels of SHBG" - Note: I need to review SHBG but they way I understand it it lowers free testosterone (binds it) which can be a bad thing however some say that binding that testosterone keeps it from being converted to DHT suggesting that SHBG can help prevent balding. This article claims 8% of our population has diabetes. The below abstract in the abstract section says "The prevalence of T2DM was 14.0% and 10.4% in men and women" [in China]. I not sure if there is a different cutoff. Related study:
Study finds toxic chemicals in pregnant womens' bodies - USATODAY.com, 1/13/11 - "These chemicals include certain pesticides, flame retardants, PFCs used in non-stick cookware, phthalates (in many fragrances and plastics), pollution from car exhaust, perchlorate (in rocket fuel) and PCBs, toxic industrial chemicals banned in 1979 that persist in the environment ... BPA — an estrogen-like ingredient in plastic found in 96% of pregnant women — affects the development of the brain, prostate and behavior in children exposed both before and after birth. Lead and mercury are known to cause brain damage ... some of these chemicals may act together to cause more damage than they would alone"
Bisphenol A may have role in ovarian dysfunction - Science Daily, 1/13/11 - "Our research shows that BPA may be more harmful to women with hormonal and fertility imbalances like those found in PCOS ... These women should be alert to the potential risks and take care of themselves by avoiding excessive every-day consumption of food or drink from plastic containers ... Blood levels of BPA were nearly 60 percent higher in lean women with PCOS and more than 30 percent higher in obese women with the syndrome when compared to controls. Additionally, as BPA levels increased, so did concentrations of the male sex hormone testosterone and androstenedione, a steroid hormone that converts to testosterone"
Room light before bedtime may impact sleep quality, blood pressure and diabetes risk - Science Daily, 1/13/11 - "exposure to electrical light between dusk and bedtime strongly suppresses melatonin levels and may impact physiologic processes regulated by melatonin signaling, such as sleepiness, thermoregulation, blood pressure and glucose homeostasis ... researchers evaluated 116 healthy volunteers aged 18-30 years who were exposed to room light or dim light in the eight hours preceding bedtime for five consecutive days. An intravenous catheter was inserted into the forearms of study participants for continuous collection of blood plasma every 30-60 minutes for melatonin measurements. Results showed exposure to room light before bedtime shortened melatonin duration by about 90 minutes when compared to dim light exposure. Furthermore, exposure to room light during the usual hours of sleep suppressed melatonin by greater than 50 percent" - See melatonin at Amazon.com.
'Longevity' protein SIRT1 may ward off precursor to prostate cancer - Science Daily, 1/13/11 - "prostatic intraepithelial neoplasia (PIN) ... deletion of the Sirt1 gene in mice resulted in PIN lesion formation associated with reduced autophagy, which is the necessary degradation of a cell's own components and most likely essential for tumor suppression ... it tells you that this 'longevity' gene is normally blocking prostate cancer" - Note: Resveratrol increases Sirt1. See resveratrol products at Amazon.com:
'Thirdhand smoke' may be bigger health hazard than previously believed - Science Daily, 1/12/10 - "the invisible remains of cigarette smoke that deposits on carpeting, clothing, furniture and other surfaces -- may be even more of a health hazard than previously believed ... Exposure to them can occur to babies crawling on the carpet, people napping on the sofa, or people eating food tainted by thirdhand smoke ... nicotine interacts with ozone, in indoor air, to form potentially toxic pollutants on these surfaces"
Two medicines taken together improve control of blood pressure - Science Daily, 1/12/10 - "patients who start treatment with a single tablet containing a combination of drugs will have a 25% better response during the first six months of treatment than patients receiving conventional treatment, and -- remarkably -- are less likely to stop treatment because of side effects"
Synbiotics may protect kids from asthma: Danone study - Nutra USA, 1/12/11 - "probiotics are defined as "live microorganisms which when administered in adequate amounts confer a health benefit on the host". Prebiotics are "nondigestible substances that provide a beneficial physiological effect on the host by selectively stimulating the favourable growth or activity of a limited number of indigenous bacteria". Synbiotics are a combination of the two ... One year after the study, data was available for 75 children, and this showed that the absolute risk of asthma symptoms 'frequent wheezing' and 'wheezing and/or noisy breathing apart from colds' were 20 and 28 percent lower, respectively, in the synbiotic group" - [Abstract] - See synbiotic products at iHerb.
Common painkillers linked to increased risk of heart problems - Science Daily, 1/11/11 - "the absolute risk of cardiovascular problems among people taking painkillers was low, but the researchers did find that, relative to placebo, the drugs carried important risks ... rofecoxib and lumiracoxib were associated with twice the risk of heart attack, while ibuprofen was associated with more than three times the risk of stroke. Etoricoxib and diclofenac were associated with the highest (around four times) risk of cardiovascular death ... Naproxen appeared least harmful in terms of cardiovascular safety among the seven analysed preparations" - See the long version at http://www.bmj.com/content/342/bmj.c7086.full.
Use of high-intensity statin therapy with simvastatin 80 mg and atorvastatin 80 mg in primary care - Int J Clin Pract. 2011 Feb;65(2):120-6 - "The present study suggests that atorvastatin 80 mg compares favourably to simvastatin in terms of efficacy and has a similar tolerability profile. Conclusion: This retrospective observational study suggests that despite national guidelines, atorvastatin 80 mg is used in clinical practice and is more effective and at least as well tolerated as simvastatin 80 mg"
SHBG, Sex Hormones, and Inflammatory Markers in Older Women - J Clin Endocrinol Metab. 2011 Jan 14 - "In premenopausal and older women, high testosterone and estradiol (E2) and low SHBG levels are associated with insulin resistance and diabetes, conditions characterized by low-grade inflammation ... SHBG was negatively associated with CRP (P = 0.007), IL-6 (P = 0.008), and sIL-6r (P = 0.02). In addition, testosterone was positively associated with CRP (P = 0.006), IL-6 (P = 0.001), and TNF-α (P = 0.0002). The negative relationship between testosterone and sIL-6r in an age-adjusted model (P = 0.02) was no longer significant in a fully adjusted model (P = 0.12). E2 was positively associated with CRP (P = 0.002) but not with IL-6 in fully adjusted models. In a final model including E2, testosterone, and SHBG, and all the confounders previously considered, SHBG (0.23 +/- 0.08; P = 0.006) and E2 (0.21 +/- 0.08; P = 0.007), but not testosterone (P = 0.21), were still significantly associated with CRP. Conclusion: In late postmenopausal women not on hormone replacement therapy, SHBG and E2 are, respectively, negative and positive, independent and significant correlates of a proinflammatory state"
RESVERATROL-MEDIATED SIRT-1 INTERACTIONS WITH P300 MODULATE RANKL-ACTIVATION OF NF-kappaB SIGNALING AND INHIBIT OSTEOCLASTOGENESIS IN BONE-DERIVED CELLS - J Biol Chem. 2011 Jan 14 - "Resveratrol is a polyphenolic phyto-estrogen that has been shown to exhibit potent anti-oxidant, anti-inflammatory and anti-catabolic properties. Increased osteoclastic and decreased osteoblastic activity result in bone resorption and loss of bone mass. These changes have been implicated in pathological processes in rheumatoid arthritis (RA) and osteoporosis. Receptor activator of NF-kappaB ligand (RANKL), a member of the TNF superfamily, is a major mediator of bone loss. In this study we investigated the effects of resveratrol on RANKL during bone morphogenesis in high-density bone cultures in vitro ... Treatment with RANKL induced formation of TRAP positive multinucleated cells that exhibited morphological features of osteoclasts. RANKL induced NF-kappaB activation, whereas pre-treatment with resveratrol completely inhibited this activation, suppressed the activation of IkappaBα kinase, IkappaBα phosphorylation and degradation ... Resveratrol inhibited RANKL-induced acetylation and nuclear translocation of NF-kappaB in a time and concentration dependent manner. In addition, activation of Sirt-1 (a histone deacetylase) by resveratrol induced Sirt-1-p300 association in bone-derived and pre-osteoblastic cells, leading to deacetylation of RANKL-induced NF-kappaB, inhibition of NF-kappaB transcriptional activation and osteoclastogenesis. Co-treatment with resveratrol activated the bone transcription factor Cbfa-1, Sirt-1 and induced the formation of Sirt-1/Cbfa-1-complexes. Overall, these results demonstrate that resveratrol-activated Sirt-1 plays pivotal roles in regulating the balance between osteoclastic versus osteoblastic activity result in bone formation in vitro thereby highlighting its therapeutic potential for treating osteoporosis and RA-related bone loss" - See resveratrol products at Amazon.com.
Plasma isoflavones and the risk of lung cancer in women: A nested case-control study in Japan - Cancer Epidemiol Biomarkers Prev. 2011 Jan 14 - "After exclusion of 20 lung cancer cases diagnosed in the first 3 years after blood collection, an inverse association was found between plasma genistein concentration and lung cancer risk. The multivariate-adjusted OR (95% CI) of lung cancer in the highest quintile of plasma genistein concentration as compared with that in the lowest quintile was 0.31 (0.12, 0.86) (P for trend = 0.085). Other isoflavones and total isoflavones were not associated with a significant decrease in the risk of lung cancer" - See genistein at Amazon.com.
Coffee consumption is inversely associated with type 2 diabetes in Chinese - Eur J Clin Invest. 2011 Jan 12 - "The prevalence of T2DM was 14.0% and 10.4% in men and women ... coffee intake was inversely associated with T2DM. Habitual coffee drinkers had 38-46% lower risk of T2DM than nondrinkers. Compared to nondrinkers, the adjusted odds ratios (ORs) for T2DM according to subjects with habitual coffee consumption (<1,1-6, ≥ 7 times per week) were 0.77 (0.52-1.13), 0.46 (0.28-0.76) and 0.37 (0.16-0.83), respectively. The decreasing ORs indicate a dose-response effect of coffee consumption on the likelihood of having T2DM (P < 0.001). A similar relationship was also evident in newly diagnosed T2DM (P < 0.05). The adjusted mean fasting glucose levels gradually decreased as the frequency of coffee consumption increased"
Carbohydrate Nutrition Is Associated with the 5-Year Incidence of Chronic Kidney Disease - J Nutr. 2011 Jan 12 - "participants in the 4th quartile of mean dietary GI intake compared with those in the first quartile (reference) had a 55% increased likelihood of having eGFR < 60 mL⋅min(-1)⋅1.73 m(-2) [multivariable-adjusted OR = 1.55 (95% CI = 1.07-2.26); P-trend = 0.01]. After multivariable adjustment, participants in the 4th quartile of dietary cereal fiber intake compared with those in the first quartile (reference) had a 50% reduced risk of incident moderate CKD (P-trend = 0.03). Higher baseline consumption of energy-dense, nutrient-poor sources of carbohydrate (e.g. cookies) yielded a 3-fold higher risk of incident CKD (P-trend = 0.01). In summary, we observed a novel link between high cereal fiber intake and reduced incidence of moderate CKD and this was supported by the cross-sectional association with dietary GI. Conversely, our data suggest that higher intake of energy-dense, nutrient-poor sources of carbohydrate, potentially through acute hyperglycemia, could impair renal function"
Dietary zinc and prostate cancer survival in a Swedish cohort - Am J Clin Nutr. 2011 Jan 12 - "High dietary zinc intake was associated with a reduced risk of prostate cancer-specific mortality (HR(Q4 vs Q1): 0.64; 95% CI: 0.44, 0.94; P for trend = 0.05) in the study population. The association was stronger in men with localized tumors (HR: 0.24; 95% CI: 0.09, 0.66; P for trend = 0.005). Zinc intake was not associated with mortality from other causes" - See Jarrow Zinc Balance at Amazon.com (some studies show that taking zinc can cause a difficiency of copper).
Synergistic, Additive, and Antagonistic Effects of Food Mixtures on Total Antioxidant Capacities - J Agric Food Chem. 2011 Jan 11 - "When foods are consumed together, the total antioxidant capacity of food mixtures may be modified via synergistic, additive, or antagonistic interactions among these components, which may in turn alter their physiological impacts ... The results indicated that within the same food category, 13, 68, and 21% of the combinations produced synergistic, additive, and antagonistic interactions, respectively, while the combinations produced 21, 54, and 25% synergistic, additive, and antagonistic effects, respectively, across food categories. Combining specific foods across categories (e.g., fruit and legume) was more likely to result in synergistic antioxidant capacity than combinations within a food group. Combining raspberry and adzuki bean extracts demonstrated synergistic interactions in all four chemical-based assays. Compositional changes did not seem to have occurred in the mixture. Results in this study suggest the importance of strategically selecting foods or diets to maximum synergisms as well as to minimum antagonisms in antioxidant activity"
Chronic oral ingestion of L-carnitine and carbohydrate increases muscle carnitine content and alters muscle fuel metabolism during exercise in humans: the dual role of muscle carnitine in exercise metabolism - J Physiol. 2011 Jan 4 - "total carnitine (TC) ... At 50% VO2max, the Carnitine group utilised 55% less muscle glycogen compared to Control (P<0.05) and 31% less pyruvate dehydrogenase complex activation (PDCa) compared to before supplementation (P<0.05). Conversely, at 80% VO2max, muscle PDCa was 38% higher (P<0.05), acetylcarnitine content showed a trend to be 16% greater (P<0.10), muscle lactate content was 44% lower (P<0.05) and the muscle PCr/ATP ratio was better maintained (P<0.05) in Carnitine compared to Control. The Carnitine group increased work output 11% from baseline in the performance trial, while Control showed no change. This is the first demonstration that human muscle TC can be increased by dietary means and results in muscle glycogen sparing during low intensity exercise (consistent with an increase in lipid utilisation) and a better matching of glycolytic, PDC and mitochondrial flux during high intensity exercise, thereby reducing muscle anaerobic ATP production. Furthermore, these changes were associated with an improvement in exercise performance" - See l-carnitine at Amazon.com.
Effect of omega-3 polyunsaturated fatty acid supplementation on semen profile and enzymatic anti-oxidant capacity of seminal plasma in infertile men with idiopathic oligoasthenoteratospermia: a double-blind, placebo-controlled, randomised study - Andrologia. 2011 Feb;43(1):38-47 - "Effective medical treatments of infertile men with idiopathic oligoasthenoteratospermia (OAT) have yet to be determined ... A significant improvement of sperm cell total count (from 38.7 +/- 8.7 ' 10(6) to 61.7 +/- 11.2 ' 10(6) , P = 0.001) and sperm cell concentration (from 15.6 +/- 4.1 ' 10(6) per ml to 28.7 +/- 4.4 ' 10(6) per ml, P = 0.001) was observed in the omega-3 group. A significant positive correlation was found between the EPA and DHA in seminal plasma and the semen parameters. Seminal plasma EPA and DHA concentrations were positively correlated with seminal plasma SOD-like and catalase-like activity (both P = 0.001). In seminal plasma, both SOD-like and catalase-like activity were positively correlated with sperm count, sperm motility, and sperm morphology. Oligoasthenoteratospermic men with low levels of EPA and DHA may benefit from omega-3 FA supplementation" - See Mega Twin EPA at Amazon.com and Jarrow Max DHA at Amazon.com.
Synbiotics prevent asthma-like symptoms in infants with atopic dermatitis - Allergy. 2011 Feb;66(2):170-177 - "The prevalence of 'frequent wheezing' and 'wheezing and/or noisy breathing apart from colds' was significantly lower in the synbiotic than in the placebo group (13.9%vs 34.2%, absolute risk reduction (ARR) -20.3%, 95% CI -39.2% to -1.5%, and 2.8%vs 30.8%, ARR -28.0%, 95% CI -43.3% to -12.5%, respectively). Significantly less children in the synbiotic than in the placebo group had started to use asthma medication after baseline (5.6%vs 25.6%, ARR -20.1%, 95% CI -35.7% to -4.5%)" - See synbiotic products at iHerb.
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