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Recent Longevity News for the seven days ending 8/4/10.  You should consult your doctor if you are taking any medications.

Olive oil extract shows brain protecting benefits - Nutra USA, 8/3/10 - "the olive oil compound reduced the cell damaging effects of the oxidative and nitrosative stress in a dose-dependent manner, with higher doses providing increased protection" - [Abstract] - See olive leaf extract at Amazon.com.

Resveratrol’s anti-inflammatory power gets human data boost - Nutra USA, 8/3/10 - "The results demonstrated in the research are the first time that such findings have been seen in humans, but are consistent with potential antiatherogenic and antiaging effects of resveratrol. Concluding that PCE “has a comprehensive suppressive effect on oxidative and inflammatory stress.”" -[Abstract] - See resveratrol products at Amazon.com.

Chili peppers may come with blood pressure benefits - Science Daily, 8/3/10 - "We found that long-term dietary consumption of capsaicin, one of the most abundant components in chili peppers, could reduce blood pressure in genetically hypertensive rats" - See capsaicin supplements at Amazon.com.

Gum inflammation linked to Alzheimer's disease - Science Daily, 8/3/10 - "cognitively normal subjects with periodontal inflammation are at an increased risk of lower cognitive function compared to cognitively normal subjects with little or no periodontal inflammation ... subjects with Alzheimer's disease had a significantly higher level of antibodies and inflammatory molecules associated with periodontal disease in their plasma compared to healthy people ... the Digit Symbol Test, or DST, a part of the standard measurement of adult IQ ... periodontal inflammation at age 70 was strongly associated with lower DST scores at age 70. Subjects with periodontal inflammation were nine times more likely to test in the lower range of the DST compared to subjects with little or no periodontal inflammation" - Note:  See my dental page.  Gum disease has been linked to several other heath conditions including diabetes and heart disease.  Over the years I've tried several methods for gum disease including floss, Periostat and Arestin and here is the only method that worked:

Certain meat components may increase bladder cancer risk, study suggests - Science Daily, 8/2/10 - "People whose diets had the highest amount of total dietary nitrite (from all sources and not just from meat), as well as those whose diets had the highest amount of nitrate plus nitrite from processed meats had a 28 percent to 29 percent increased risk of developing bladder cancer compared with those who consumed the lowest amount of these compounds"

The following YouTube videos are interesting regarding telomeres and telomerase.   It claims that reproductive cells don’t age because they have a gene that produces the telomerase enzyme. The telomerase enzyme causes the telomeres that breaks off to be replaced. Telomerase can actually lengthen telomeres. The rest of the cells in our body also have the gene that produces the telomerase enzyme but that gene is turned off in those cells. They have found 33 drugs that causes that gene to turn on. Theoretically that should prevent the telomere from shortening and therefore prevent aging (and wrinkles).

YouTube - What's a Telomere and Why is it Important to the Aging Process – 10:10
YouTube - Part 2: Sierra Sciences CEO Bill Andrews, Ph.D. – 10:57

Also see my telomere page at http://www.qualitycounts.com/fptelomerase.html . You can slow the telomere shortening with things like vitamin D.

Calcium supplements play an important role in maintaining bone health, experts say - Science Daily, 7/29/10 - "The authors of the meta-analysis examined the effects of calcium supplements on the risk of cardiovascular events, concluding there is an increased risk, and calling for a reassessment of the role of calcium supplements for osteoporosis. According to CRN, these conclusions are dramatically overstated, considering the limitations of meta-analysis, in general, and this meta-analysis, specifically ... The authors characterize these findings as though all of the selected studies suggest increased risk. In fact, the opposite is true: most of the studies do not suggest increased risk ... these researchers are making sweeping judgments about the value of calcium supplements by only assessing a handful of handpicked studies ..." - Also see Industry : Calcium research “cherry picked” results - Nutra USA, 7/30/10.

Calcium supplements linked to increased risk of heart attack, study finds - Science Daily, 7/29/10 - "calcium supplements were associated with about a 30% increased risk of heart attack and smaller, non-significant, increases in the risk of stroke and mortality"

Plant compound resveratrol shown to suppresses inflammation, free radicals in humans - Science Daily, 7/29/10 - "Resveratrol, a popular plant extract shown to prolong life in yeast and lower animals due to its anti-inflammatory and antioxidant properties, appears also to suppress inflammation in humans ... resveratrol has been shown to prolong life and to reduce the rate of aging in yeast, roundworms and fruit flies, actions thought to be affected by increased expression of a particular gene associated with longevity ... The compound also is thought to play a role in insulin resistance as well, a condition related to oxidative stress, which has a significant detrimental effect on overall health ... resveratrol suppressed the generation of free radicals, or reactive oxygen species, unstable molecules known to cause oxidative stress and release proinflammatory factors into the blood stream, resulting in damage to the blood vessel lining ... Blood samples from persons taking resveratrol also showed suppression of the inflammatory protein tumor necrosis factor (TNF) and other similar compounds that increase inflammation in blood vessels and interfere with insulin action, causing insulin resistance and the risk of developing diabetes" - See resveratrol products at Amazon.com.

Memory's master switch: Molecular power behind memory discovered - Science Daily, 7/29/10 - "Higher concentrations of GABA near a synapse induced a stronger activation of its receptors, weakening basal synapse strength. As a result, GABA makes this synapse more liable to the formation of new memories" - See GABA at Amazon.com.

Aging and longevity tied to specific brain region in mice - Science Daily, 7/28/10 - "mice with increased brain SIRT1 have internal mechanisms that make them use energy more efficiently, which helps them move around in search of food even after a long fast. This increased energy-efficiency could help delay aging and extend lifespan ... SIRT1 is at the center of a network that connects metabolism and aging" - Related articles on SIRT1:

Abstracts from this week's Doctor's Guide Nutrition/Dietetics plus abstracts from my RSS feeds (Click here for the journals, the PubMed ones at the top):

Cytoprotective effects of olive mill wastewater extract and its main constituent hydroxytyrosol in PC12 cells - Pharmacol Res. 2010 Jun 16 - "Following a short-term exposure (30min) to the compounds of interest, cells were subjected to oxidative or nitrosative stress by adding either ferrous iron or sodium nitroprusside to the cell culture medium for 18h, respectively. Cytotoxicity was assessed by measuring MTT reduction, cellular ATP levels and mitochondrial membrane potential in the absence and presence of HT or HT-rich olive mill wastewater extract. The results we obtained mainly confirm our previous observation of promising cytoprotection of brain cells by HT-rich olive mill wastewater extract in different stressor paradigms" - See olive leaf extract at Amazon.com.

An Antiinflammatory and Reactive Oxygen Species Suppressive Effects of an Extract of Polygonum Cuspidatum Containing Resveratrol - J Clin Endocrinol Metab. 2010 Jun 9 - "The extract induced a significant reduction in reactive oxygen species generation, the expression of p47(phox), intranuclear nuclear factor-kappaB binding, and the expression of jun-N-terminal kinase-1, inhibitor of kappaB-kinase-beta, phosphotyrosine phosphatase-1B, and suppressor of cytokine signaling-3 in mononuclear cells when compared with the baseline and the placebo. PCE intake also suppressed plasma concentrations of TNF-alpha, IL-6, and C-reactive protein. There was no change in these indices in the control group given placebo. Conclusions: The PCE-containing resveratrol has a comprehensive suppressive effect on oxidative and inflammatory stress" - See resveratrol products at Amazon.com.

Can the Mediterranean diet lower HbA1c in type 2 diabetes? Results from a randomized cross-over study - Nutr Metab Cardiovasc Dis. 2010 Jul 29 - "Compared with usual diet, on the ad libitum Mediterranean intervention diet glycosylated haemoglobin fell from 7.1% (95% CI: 6.5-7.7) to 6.8%"

Acute resveratrol supplementation improves flow-mediated dilatation in overweight/obese individuals with mildly elevated blood pressure - Nutr Metab Cardiovasc Dis. 2010 Jul 29 - "Flow-mediated dilatation of the brachial artery (FMD) is a biomarker of endothelial function and cardiovascular health. Impaired FMD is associated with several cardiovascular risk factors including hypertension and obesity. Various food ingredients such as polyphenols have been shown to improve FMD ... One hour after consumption of the supplement, plasma resveratrol and FMD were measured. Data were analyzed by linear regression versus log(10) dose of resveratrol. 14 men and 5 women (age 55 +/- 2 years, BMI 28.7 +/- 0.5 kg m(-2), BP 141 +/- 2/89 +/- 1 mmHg) completed this study. There was a significant dose effect of resveratrol on plasma resveratrol concentration (P < 0.001) and on FMD (P < 0.01), which increased from 4.1 +/- 0.8% (placebo) to 7.7 +/- 1.5% after 270 mg resveratrol. FMD was also linearly related to log(10) plasma resveratrol concentration" - See resveratrol products at Amazon.com.

Red meat consumption and risk of heart failure in male physicians - Nutr Metab Cardiovasc Dis. 2010 Jul 30 - "there was a positive and graded relation between red meat consumption and HF [hazard ratio (95% CI) of 1.0 (reference), 1.02 (0.85-1.22), 1.08 (0.90-1.30), 1.17 (0.97-1.41), and 1.24 (1.03-1.48) from the lowest to the highest quintile of red meat, respectively"

Waist Circumference but Not Body Mass Index Predicts Long-Term Mortality in Elderly Subjects with Chronic Heart Failure - J Am Geriatr Soc. 2010 Jul 28 - "Mortality increased as WC increased in elderly subjects without CHF (from 47.8% to 56.7%, P=.01), and the increase was even greater in patients with CHF (from 58.1% to 82.0%, P=.01). In contrast, mortality decreased as BMI increased in elderly subjects without CHF (from 53.8% to 46.1%, P0 =.046) but not in those with CHF. According to Cox regression analysis, BMI protected against long-term mortality in the absence but not in the presence of CHF. In the absence of CHF, WC was associated with a 2% increased risk of long-term mortality for each 1-cm greater WC (Hazard Ratio (HR)=1.02, 95% confidence interval (CI)=1.01-1.03; P<.001), versus 5% increased in the presence of CHF (HR=1.06, 95% CI=1.02-1.10; P<.001)"

Resveratrol and Small Artery Compliance and Remodeling in the Spontaneously Hypertensive Rat - Am J Hypertens. 2010 Jul 29 - "The ability of resveratrol to limit the increase in compliance of SHR arteries is likely related to inhibitory effects on remodeling and pro-growth ERK signaling rather than blood pressure or arterial wall component stiffness" - See resveratrol products at Amazon.com.

Long-Term High Intake of Whole Proteins Results in Renal Damage in Pigs - J Nutr. 2010 Jul 28 - "These findings suggest that long-term intakes of protein at the upper limit of the AMDR from whole protein sources may compromise renal health"

Whole Grains Are Associated with Serum Concentrations of High Sensitivity C-Reactive Protein among Premenopausal Women - J Nutr. 2010 Jul 28 - "Whole grain intake was inversely associated with hs-CRP concentrations after adjusting for age, race, BMI, illness, and antiinflammatory drug use. Consumers of between 0 and 1 serving/d of whole grains had, on average, 11.5% lower hs-CRP concentrations (P = 0.02) and consumers of >/=1 serving/d had 12.3% lower hs-CRP concentrations (P = 0.02) compared with nonconsumers"

N-Acetylcysteine interacts with copper to generate hydrogen peroxide and selectively induce cancer cell death - Cancer Lett. 2010 Jul 26 - "NAC/Cu(II) significantly alters growth and induces apoptosis in human cancer lines, yet NAC/Zn(II) and NAC/Fe(III) do not. We further confirmed that this cytotoxicity of NAC/Cu(II) is attributed to reactive oxygen species (ROS). These findings indicate that the combination of Cu(II) and thiols generates cytotoxic ROS that induce apoptosis in cancer cells. They also indicate a fourth class of anti-neoplastic metal-binding compounds, the "ROS generators"" - See n-acetyl cysteine at Amazon.com.

Glutamine in critical illness: the time has come, the time is now - Crit Care Clin. 2010 Jul;26(3):515-25 - "Glutamine (GLN) has been shown to be a key pharmaconutrient in the body's response to stress and injury. It exerts its protective effects via multiple mechanisms, including direct protection of cells and tissue from injury, attenuation inflammation, and preservation of metabolic function. Data support GLN as an ideal pharmacologic intervention to prevent or treat multiple organ dysfunction syndrome after sepsis or other injuries in the intensive care unit population. A large and growing body of clinical data shows that in well-defined critically ill patient groups GLN can be a life-saving intervention" - See L-glutamine at Amazon.com

Increased plasma PYY levels following supplementation with the functional fiber PolyGlycopleX in healthy adults - Eur J Clin Nutr. 2010 Jul 28 - "A variety of dietary fibers have been shown to alter satiety hormone gene expression and secretion. The objective of this study was to examine plasma satiety hormone concentrations in healthy subjects consuming either PolyGlycopleX (PGX) or control (skim milk powder) for 21 days ... Primary outcomes measured at three visits (V1, V2 and V3) were plasma active glucagon-like peptide-1 (GLP-1) total ghrelin, peptide YY (PYY) and insulin. Results: There was a significant effect of visit for fasting PYY with control participants experiencing decreased PYY levels over time while PGX prevented this decline. When stratified by body mass index (BMI), PGX increased fasting PYY levels from week 1 to week 3 compared with control in participants with BMI <23 kg/m(2). There was a significant effect of visit for fasting ghrelin with levels decreasing in both PGX and control groups over time. No differences were detected in fasting GLP-1 levels. Although there was a 14% reduction in fasting insulin between V1 and V3 with PGX this was not significantly different from control" - Note:  I don't know how they determine that a 14% reduction isn't significant.  See PGX at Amazon.com.

Association between alcohol consumption and carotid intima-media thickness in a healthy population: data of the STRATEGY study (Stress, Atherosclerosis and ECG Study) - Eur J Clin Nutr. 2010 Jul 28 - "The mean a href="../fphardeningofarteries.htm">IMT was significantly higher in men with an alcohol intake above the upper limit of 20 g/day than in men with an alcohol intake <20 g/day (P<0.001). According to a stepwise linear regression model adjusted for age, conventional risk factors, nutrition and physical activity, the IMT increases by 0.0253 mm per 21.4 g/day intake of alcohol in men (P<0.05).Conclusions: The STRATEGY study revealed a positive association between alcohol consumption and carotid IMT in healthy men aged 30-70 years. This relationship remained significant after adjustment for nutrition, physical activity, anthropometry and conventional cardiovascular risk factors"

Blueberries Decrease Cardiovascular Risk Factors in Obese Men and Women with Metabolic Syndrome - J Nutr. 2010 Jul 21 - "Forty-eight participants with metabolic syndrome [4 males and 44 females; BMI: 37.8 +/- 2.3 kg/m(2); age: 50.0 +/- 3.0 y (mean +/- SE)] consumed freeze-dried blueberry beverage (50 g freeze-dried blueberries, approximately 350 g fresh blueberries) or equivalent amounts of fluids (controls, 960 mL water) daily for 8 wk in a randomized controlled trial. Anthropometric and blood pressure measurements, assessment of dietary intakes, and fasting blood draws were conducted at screening and at wk 4 and 8 of the study. The decreases in systolic and diastolic blood pressures were greater in the blueberry-supplemented group (-6 and -4%, respectively) than in controls (-1.5 and -1.2%) (P < 0.05), whereas the serum glucose concentration and lipid profiles were not affected. The decreases in plasma oxidized LDL and serum malondialdehyde and hydroxynonenal concentrations were greater in the blueberry group (-28 and -17%, respectively) than in the control group (-9 and -9%) (P < 0.01). Our study shows blueberries may improve selected features of metabolic syndrome and related cardiovascular risk factors at dietary achievable doses" - See blueberry extract at Amazon.com.

Associations of red meat, fat, and protein intake with distal colorectal cancer risk - Nutr Cancer. 2010 Aug;62(6):701-9 - "There was no association between total, saturated, or monounsaturated fat and distal CRC risk. In African Americans, the OR of distal CRC for the highest category of polyunsaturated fat intake was 0.28 (95% CI = 0.08-0.96). The percent of energy from protein was associated with a 47% risk reduction in Whites (Q4 OR = 0.53, 95% CI = 0.37-0.77). Red meat consumption in Whites was associated with a marginally significant risk reduction (Q4 OR = 0.66, 95% CI = 0.43-1.00). Our results do not support the hypotheses that fat, protein, and red meat increase the risk of distal CRC"

Nutrients and risk of prostate cancer - Nutr Cancer. 2010 Aug;62(6):710-8 - "Intake of trans fat was associated with the risk of PCa; the OR for the highest vs. the lowest quartile was 1.45 (95% CI = 1.16-1.81); the association was apparently stronger in subjects aged less than 65, normal weight men, and ever smokers. An increased risk was also observed with increasing intake of sucrose and disaccharides. In contrast, men in the highest quartile of cholesterol intake were at lower risk of PCa. No association was found with intake of total proteins, total fat, monounsaturated fats, polyunsaturated fats, monosaccharides, and total carbohydrates. The findings provide evidence that a diet low in trans fat could reduce PCa risk"

Mixed Tocotrienols Inhibit Prostate Carcinogenesis in TRAMP Mice - Nutr Cancer. 2010 Aug;62(6):789-94 - "mixed-tocotrienol-fed groups had a lower incidence of tumor formation along with a significant reduction in the average wet weight of genitourinary apparatus. Furthermore, mixed tocotrienols significantly reduced the levels of high-grade neoplastic lesions as compared to the positive controls. This decrease in levels of high-grade neoplastic lesions was found to be associated with increased expression of proapoptotic proteins BAD (Bcl(2) antagonist of cell death) and cleaved caspase-3 and cell cycle regulatory proteins cyclin dependent kinase inhibitors p21 and p27. In contrast, the expression of cyclins A and E were found to be decreased in mixed-tocotrienol groups. Taken together, our results show that by modulating cell cycle regulatory proteins and increasing expression of proapoptotic proteins, mixed tocotrienols suppress prostate tumorigenesis in the TRAMP mice" - See Jarrow FamilE (contains all eight members of the vitamin E family, includes Tocomin) at Amazon.com.

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